Autism Research最新文献_第3页

Relationship between service receipt during the COVID-19 pandemic and autistic children's multisystem outcomes and autism severity: A SPARK dataset analysis

IF 5.3 2区医学

Autism Research Pub Date : 2025-01-07 DOI: 10.1002/aur.3256

Jung-Mei Tsai, Anjana Bhat

{"title":"Relationship between service receipt during the COVID-19 pandemic and autistic children's multisystem outcomes and autism severity: A SPARK dataset analysis","authors":"Jung-Mei Tsai, Anjana Bhat","doi":"10.1002/aur.3256","DOIUrl":"10.1002/aur.3256","url":null,"abstract":"<p>Children with autism spectrum disorder (ASD) display a variety of core and co-occurring difficulties in social, communication, everyday functioning, cognitive, motor, and language domains. Receiving a combination of services to accommodate needs of autistic individuals is essential for improving their future outcomes. During the COVID-19 pandemic, reduced service access negatively impacted autistic children's outcomes. This study aimed to examine the relationship between service receipt and parental perceived outcomes in autistic children while accounting for various demographic, child, and parental factors. We utilized parental COVID-19 impact survey data from the SPARK study (<i>N</i> = 6067). Ordinal logistic regression analyses were used to predict perceived child outcomes. Demographic, child, and parental factors were included in the prediction models. Service receipt of SLT, ABA, PT/OT, MED, and MH were associated with perceived child outcomes. PT/OT and ABA predicted improvements in domains of social interaction, everyday activity, and overall autism severity; SLT and ABA contributed to improved perceived communication outcomes. Receiving MH and MED services was associated with worsening of perceived outcomes on all domains. Younger age, males, higher family income, lower autism severity, lower motor, function, and cognitive delay, greater language delay, and the absence of parental mental health issues were associated with greater improvements in various perceived outcomes. Overall, PT/OT and ABA services are associated with improved perceived social and functional outcomes whereas SLT and ABA services are associated with improved perceived communication outcomes. We also provide a wholistic view of factors affecting relationships between service receipt and perceived child outcomes during the pandemic.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 1","pages":"217-229"},"PeriodicalIF":5.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reports of Echolalia and Related Behaviors in Autism From Parents, Teachers, and Clinicians: Evidence From the Simon Simplex Collection

IF 5.3 2区医学

Autism Research Pub Date : 2025-01-07 DOI: 10.1002/aur.3298

Margaret L. McAllister, Tyler McFayden, Clare Harrop

{"title":"Reports of Echolalia and Related Behaviors in Autism From Parents, Teachers, and Clinicians: Evidence From the Simon Simplex Collection","authors":"Margaret L. McAllister, Tyler McFayden, Clare Harrop","doi":"10.1002/aur.3298","DOIUrl":"10.1002/aur.3298","url":null,"abstract":"<div>\u0000 \u0000 <p>Echolalia, the immediate or delayed repetition of speech, is a core diagnostic criterion for autism spectrum disorder. It has been studied for over 50 years and is well-described; however, no consensus on prevalence estimates exists for echolalia's occurrence in autistic youth. The current study sought to (1) describe endorsement of echolalia-related items using parent-, teacher-, and clinician-reports in a well-validated sample of autistic youth and (2) characterize relations between echolalia and other key factors, including age, language ability, and repetitive behaviors. Participants (<i>n</i> = 2555, 4–17 years, 13% female, 78% White) from the Simon Simplex Collection provided data from multi-informant ratings of echolalia and related behaviors. Nine parent-, clinician-, and teacher-report items were extracted from five measures to broadly capture echolalia through a composite score. Results indicated that as many as 90% of autistic individuals express echolalia at some point in their development. Hierarchical linear regression was conducted to evaluate relations between echolalia, verbal ability, and repetitive behaviors, controlling for age, sex, and autism severity. Results indicated the main effects of verbal ability and repetitive behaviors. A significant interaction qualified this main effect wherein age was negatively associated with echolalia for children with higher verbal ability, but not those with lower verbal ability, suggesting that adolescents with less generative speech may leverage echolalia as a communicative strategy. Echolalia was positively associated with repetitive behaviors across development. These associations support a dualistic interpretation of echolalia as functional communication and as a form of repetitive behavior. Future research is needed to understand the developmental trajectories of echolalia and develop affirming support for this autistic behavior.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 3","pages":"528-540"},"PeriodicalIF":5.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder 自闭症谱系障碍小脑亚区体积异常与小脑-脑结构协方差。

IF 5.3 2区医学

Autism Research Pub Date : 2025-01-03 DOI: 10.1002/aur.3287

Yu Wang, Aihua Cao, Jing Wang, He Bai, Tianci Liu, Chenxi Sun, Zhuoran Li, Yuchun Tang, Feifei Xu, Shuwei Liu

{"title":"Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder","authors":"Yu Wang, Aihua Cao, Jing Wang, He Bai, Tianci Liu, Chenxi Sun, Zhuoran Li, Yuchun Tang, Feifei Xu, Shuwei Liu","doi":"10.1002/aur.3287","DOIUrl":"10.1002/aur.3287","url":null,"abstract":"<p>The cerebellum plays a crucial role in functions, including sensory-motor coordination, cognition, and emotional processing. Compared to the neocortex, the human cerebellum exhibits a protracted developmental trajectory. This delayed developmental timeline may lead to increased sensitivity of the cerebellum to external influences, potentially extending the vulnerability period for neurological disorders. Abnormal cerebellar development in individuals with autism has been confirmed, and these atypical cerebellar changes may affect the development of the neocortex. However, due to the heterogeneity of autism spectrum disorder (ASD), the regional changes in the cerebellum and cerebellocerebral structural relationship remain unknown. To address these issues, we utilized imaging methods optimized for the cerebellum and cerebrum on 817 individuals aged 5–18 years in the ABIDE II dataset. After FDR correction, significant differences between groups were found in the right crus II/VIIB and vermis VI-VII. Structural covariance analysis revealed enhanced structural covariance in individuals with autism between the cerebellum and parahippocampal gyrus, pars opercularis, and transverse temporal gyrus in the right hemisphere after FDR correction. Furthermore, the structural covariance between the cerebellum and some regions of the cerebrum varied across sexes. A significant increase in structural covariance between the cerebellum and specific subcortical structures was also observed in individuals with ASD. Our study found atypical patterns in the structural covariance between the cerebellum and cerebrum in individuals with autism, which suggested that the underlying pathological processes of ASD might concurrently affect these brain regions. This study provided insight into the potential of cerebellocerebral pathways as therapeutic targets for ASD.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 1","pages":"83-97"},"PeriodicalIF":5.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust Autism Spectrum Disorder-Related Spatial Covariance Gray Matter Pattern Revealed With a Large-Scale Multi-Center Dataset 基于大规模多中心数据集的鲁棒性自闭症谱系障碍相关空间协方差灰质模式研究。

IF 5.3 2区医学

Autism Research Pub Date : 2024-12-31 DOI: 10.1002/aur.3303

Sheng-Zhi Ma, Xing-Ke Wang, Chen Yang, Wen-Qiang Dong, Dan-Dan Chen, Chao Song, Qiu-Rong Zhang, Yu-Feng Zang, Li-Xia Yuan

{"title":"Robust Autism Spectrum Disorder-Related Spatial Covariance Gray Matter Pattern Revealed With a Large-Scale Multi-Center Dataset","authors":"Sheng-Zhi Ma, Xing-Ke Wang, Chen Yang, Wen-Qiang Dong, Dan-Dan Chen, Chao Song, Qiu-Rong Zhang, Yu-Feng Zang, Li-Xia Yuan","doi":"10.1002/aur.3303","DOIUrl":"10.1002/aur.3303","url":null,"abstract":"<div>\u0000 \u0000 <p>Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder and its underlying neuroanatomical mechanisms still remain unclear. The scaled subprofile model of principal component analysis (SSM-PCA) is a data-driven multivariate technique for capturing stable disease-related spatial covariance pattern. Here, SSM-PCA is innovatively applied to obtain robust ASD-related gray matter volume pattern associated with clinical symptoms. We utilized T1-weighted structural MRI images (sMRI) of 576 subjects (288 ASDs and 288 typically developing (TD) controls) aged 7–29 years from the Autism Brain Imaging Data Exchange II (ABIDE II) dataset. These images were analyzed with SSM-PCA to identify the ASD-related spatial covariance pattern. Subsequently, we investigated the relationship between the pattern and clinical symptoms and verified its robustness. Then, the applicability of the pattern under different age stages were further explored. The results revealed that the ASD-related pattern primarily involves the thalamus, putamen, parahippocampus, orbitofrontal cortex, and cerebellum. The expression of this pattern correlated with Social Response Scale and Social Communication Questionnaire scores. Moreover, the ASD-related pattern was robust for the ABIDE I dataset. Regarding the applicability of the pattern for different age stages, the effect sizes of its expression in ASD were medium in the children and adults, while small in adolescents. This study identified a robust ASD-related pattern based on gray matter volume that is associated with social deficits. Our findings provide new insights into the neuroanatomical mechanisms of ASD and may facilitate its future intervention.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 2","pages":"312-324"},"PeriodicalIF":5.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical Regional Accent in Autistic Children: A Perception Study 自闭症儿童的非典型地区口音：一项知觉研究。

IF 5.3 2区医学

Autism Research Pub Date : 2024-12-31 DOI: 10.1002/aur.3300

Federica Beccaria, Gloria Gagliardi, Mikhail Kissine

引用次数: 0

Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case–Control Study 中国儿童血清锰、锌、铜和硒浓度与自闭症谱系障碍的关系：一项病例对照研究。

IF 5.3 2区医学

Autism Research Pub Date : 2024-12-27 DOI: 10.1002/aur.3302

Yong Zhang, Fang Xie, Sheng Li, Ying Li, Liting Yang, Zhen Wang, Jinlin Lei, Huailan Guo

{"title":"Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case–Control Study","authors":"Yong Zhang, Fang Xie, Sheng Li, Ying Li, Liting Yang, Zhen Wang, Jinlin Lei, Huailan Guo","doi":"10.1002/aur.3302","DOIUrl":"10.1002/aur.3302","url":null,"abstract":"<div>\u0000 \u0000 <p>Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case–control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD. Compared with TD, ASD has lower Zn and Se levels and higher Cu levels. The restricted cubic spline model showed J-shaped non-linearity, L-shaped non-linearity, and positive linearity correlations between Mn, Zn, Cu, and ASD. Zn and Cu were negatively and positively correlated with ASD symptoms, respectively. The superoxide dismutase (SOD) mediated 50.53% and 39.07% of the association between Zn, Se, and ASD, respectively. Bayesian kernel machine regression (BKMR) confirmed a U-shaped correlation between the element mixtures and ASD. Interactions of Mn with the other three elements and Cu with Zn were also observed. Our results confirm that the independent and combined exposure to the four trace elements was associated with ASD, with oxidative stress being an important mechanism. Due to the potential interactions between the elements, further research is needed to explore their involvement in the pathogenesis and progression of ASD from a combined perspective, as well as the beneficial and harmful concentration ranges.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 2","pages":"427-436"},"PeriodicalIF":5.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acoustic Exaggeration Enhances Speech Discrimination in Young Autistic Children 声音夸张能增强自闭症幼儿的语音辨别能力

IF 5.3 2区医学

Autism Research Pub Date : 2024-12-27 DOI: 10.1002/aur.3301

Luodi Yu, Lizhi Ban, Aiwen Yi, Jing Xin, Suping Li, Suiping Wang, Laurent Mottron

{"title":"Acoustic Exaggeration Enhances Speech Discrimination in Young Autistic Children","authors":"Luodi Yu, Lizhi Ban, Aiwen Yi, Jing Xin, Suping Li, Suiping Wang, Laurent Mottron","doi":"10.1002/aur.3301","DOIUrl":"10.1002/aur.3301","url":null,"abstract":"<p>Child-directed speech (CDS), which amplifies acoustic and social features of speech during interactions with young children, promotes typical phonetic and language development. In autism, both behavioral and brain data indicate reduced sensitivity to human speech, which predicts absent, decreased, or atypical benefits of exaggerated speech signals such as CDS. This study investigates the impact of exaggerated fundamental frequency (F0) and voice-onset time on the neural processing of speech sounds in 22 Chinese-speaking autistic children aged 2–7 years old with a history of speech delays, compared with 25 typically developing (TD) peers. Electroencephalography (EEG) data were collected during passive listening to exaggerated and non-exaggerated syllables. A time-resolved multivariate pattern analysis (MVPA) was used to evaluate the potential effects of acoustic exaggeration on syllable discrimination in terms of neural decoding accuracy. For non-exaggerated syllables, neither the autism nor the TD group achieved above-chance decoding accuracy. In contrast, for exaggerated syllables, both groups achieved above-chance decoding, indicating significant syllable discrimination, with no difference in accuracy between the autism and TD groups. However, the temporal generalization patterns in the MVPA results revealed distinct neural mechanisms supporting syllable discrimination between the groups. Although the TD group demonstrated a left-hemisphere advantage for decoding and generalization, the autism group displayed similar decoding patterns between hemispheres. These findings highlight the potential of selective acoustic exaggeration to support speech learning in autistic children, underscoring the importance of tailored, sensory-based interventions.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 2","pages":"402-414"},"PeriodicalIF":5.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What We Know and Do Not Know About Camouflaging, Impression Management, and Mental Health and Wellbeing in Autistic People 我们对自闭症患者的伪装、印象管理、心理健康和幸福的了解和不了解。

IF 5.3 2区医学

Autism Research Pub Date : 2024-12-24 DOI: 10.1002/aur.3299

Valeria Khudiakova, Mishel Alexandrovsky, Wei Ai, Meng-Chuan Lai

{"title":"What We Know and Do Not Know About Camouflaging, Impression Management, and Mental Health and Wellbeing in Autistic People","authors":"Valeria Khudiakova, Mishel Alexandrovsky, Wei Ai, Meng-Chuan Lai","doi":"10.1002/aur.3299","DOIUrl":"10.1002/aur.3299","url":null,"abstract":"<p>Camouflaging is an impression management strategy employed by some autistic people, widely seen as a response to the pervasive stigma surrounding autism in society. Autistic narratives and lived experiences consistently link camouflaging to anxiety, depression, suicide risks, and autistic burnout. Quantitative research is yet to determine the nature of these relationships, with a significant portion of recent studies providing inconsistent evidence. While camouflaging can be a compelled survival strategy in social environments, it might also contribute to positive outcomes such as securing employment and forming positive social relationships, implicating a complex interrelationship with mental health and wellbeing. We advocate for using a transactional impression management framework to understand camouflaging and wellbeing and address the inconsistencies in research. Through examining the transactions among a person's individual and cognitive characteristics, behavior modification strategies, and the particular social contexts they find themselves in, this framework guides new empirical research directions to delineate the relationships between camouflaging, impression management, mental health, and wellbeing. There is a need to develop multiple measures of camouflaging that delineate the motivations, ability, effortfulness, and perceived effectiveness of camouflaging and examine how a person's social behaviors are perceived in different social environments. Research should also focus on intersectionality, sociocultural influences, and diverse autistic voices to study context-sensitive camouflaging experiences across the autistic population.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 2","pages":"273-280"},"PeriodicalIF":5.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the Relationship Between Parental Broader Autism Phenotype Traits, Offspring Autism, and Parental Mental Health 父母广义自闭症表型特征、后代自闭症和父母心理健康关系的研究。

IF 5.3 2区医学

Autism Research Pub Date : 2024-12-23 DOI: 10.1002/aur.3295

Fátima El-Bouhali-Abdellaoui, Núria Voltas, Paula Morales-Hidalgo, Josefa Canals

{"title":"Examining the Relationship Between Parental Broader Autism Phenotype Traits, Offspring Autism, and Parental Mental Health","authors":"Fátima El-Bouhali-Abdellaoui, Núria Voltas, Paula Morales-Hidalgo, Josefa Canals","doi":"10.1002/aur.3295","DOIUrl":"10.1002/aur.3295","url":null,"abstract":"<p>Broader Autism Phenotype (BAP) traits may be present in parents of children on the autism spectrum. However, the prevalence and impact of these traits on parental mental health is poorly understood. We explore BAP traits and its relationship to mental health in 228 fathers and 261 mothers from a sample of 266 scholars from the EPINED study (Spain) grouped as follows: non-autism (<i>N</i> = 122), autism traits (<i>N</i> = 93: 38 subthreshold autism and 55 autism symptoms) and autism (<i>N</i> = 51). BAP rates were higher in fathers (36.9%) than in mothers (26.1%). Moreover, BAP was significantly more frequent in fathers of autistic children (52.3%) than in fathers of children without autistic traits (28.0%), with no differences between autistic conditions groups. Mothers of autistic children exhibited higher psychological distress (36.0%) than mothers of comparison group (19.2%). Fathers with BAP obtained significantly higher scores in emotional problems than fathers without BAP. Multivariate analyses showed that, fathers' emotional problems were associated with their BAP traits, whereas in mothers they were associated with having a child with autism as well as the child's emotional dysregulation. Identifying BAP in parents of autistic conditions children can help professionals to provide specific strategies for improving the well-being of children and parents.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 2","pages":"387-401"},"PeriodicalIF":5.3,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilizing network analysis to identify core items of quality of life for children with autism spectrum disorder 运用网络分析方法识别自闭症谱系障碍儿童生活质量的核心项目。

IF 5.3 2区医学

Autism Research Pub Date : 2024-12-19 DOI: 10.1002/aur.3292

Jin Liu, Laura C. Chezan, Yue Zhao, Sarah K. Hood, Erik Drasgow, Han Wang

引用次数: 0