Autism Research最新文献

{"title":"Epidemiology of Alzheimer Disease and Related Dementia Among Medicare and Medicaid Enrolled Autistic Adults, 2011–2019","authors":"Salina Tewolde,&nbsp;Samuel B. Rosenberg,&nbsp;Josue Antonio G. Estrada,&nbsp;Marcia Pescador Jimenez,&nbsp;Ashley Scott,&nbsp;Alianna Higgins,&nbsp;Eric Rubenstein","doi":"10.1002/aur.70035","DOIUrl":"10.1002/aur.70035","url":null,"abstract":"<div>\u0000 \u0000 <p>Alzheimer's disease and related dementias (ADRD) are burdensome and lethal conditions that have been hypothesized to be related to autism through shared genetic etiologies and environmental risk factors. Our objective was to use longitudinal Medicaid and Medicare data to describe the epidemiology of ADRD in publicly insured autistic adults. We used all claims and encounters from 2011 to 2019 to identify autism and ADRD. We calculated prevalence, incidence, age at onset, and created survival curves. There were 90,229 autistic adults ≥ 30 years of age and enrolled for at least 1 year in Medicaid and/or Medicare and 267 ADRD cases. Prevalence of ADRD was 2.09% (95% CI: 1.99%, 2.20%) in 2011 and 8.11% (95% CI: 7.92%, 8.30%) in 2019. Mean age at ADRD onset was 59.3 years (SD: 14.2). Mean age among men was 58.3 years (SD: 13.8) and 61.0 years among females. Incidence of ADRD was higher in autistic adults with intellectual disability with no difference by sex. ADRD is a prevalent condition in middle- and older-aged adults identified with autism in the Medicaid and Medicare system. Understanding the diagnostic process and phenotype of ADRD will be important to improve identification and treatment.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 5","pages":"1077-1086"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Maternal Alcohol Exposure During the First Trimester of Pregnancy in Relation to Early Learning Ability, Behavioral Problems, and Autistic Traits in Preschool Children With or Without Autism Spectrum Disorder","authors":"Lin H. Tian,&nbsp;Brain Barger,&nbsp;Karen Pazol,&nbsp;Laura A. Schieve,&nbsp;Jacquelyn Bertrand,&nbsp;Carolyn DiGuiseppi,&nbsp;April D. Summers,&nbsp;Alicia Dunajcik,&nbsp;Lucinda England,&nbsp;Tessa L. Crume,&nbsp;Lisa D. Wiggins","doi":"10.1002/aur.70025","DOIUrl":"10.1002/aur.70025","url":null,"abstract":"<div>\u0000 \u0000 <p>Prenatal alcohol exposure has been linked to adverse neurodevelopmental outcomes. However, its effects on developmental outcomes in children with autism spectrum disorder (ASD) remain unclear. We examined associations between prenatal alcohol exposure during the first trimester (PAE-FT) and early learning ability, behavioral problems, and severity of autistic traits in preschool-aged children in a large multi-site case–control study, the Study to Explore Early Development. Children were classified as ASD (<i>n</i> = 1237) or population comparison without ASD (POP, <i>n</i> = 1334) after an in-person assessment covering cognitive abilities and detailed autistic traits. Mothers completed questionnaires on their child's behavior and autism-related traits, as well as their alcohol use during pregnancy. Of children in the ASD and POP groups, 18.5% and 20.2%, respectively, were exposed to PAE-FT. Exposure to 3 or more alcoholic drinks per week was associated with increased externalizing behaviors (i.e., attention deficits and aggressive behaviors) in children in both the ASD and POP groups, and with exacerbated social communication and interaction deficits in children with ASD only. First trimester exposure to 1–2 alcoholic drinks per week was associated with early learning delays for children in the ASD group, but not the POP group. As expected, our findings suggest that PAE-FT is associated with adverse behavioral development of children regardless of ASD status. However, PAE-FT may exacerbate autism-specific developmental problems and learning difficulties in children with ASD. Gathering a prenatal alcohol exposure history for children with and without ASD could contribute to a better understanding of developmental trajectories, aiding informed decisions for interventions and support.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 5","pages":"1087-1096"},"PeriodicalIF":5.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor-Communication Skill Link in Minimally Speaking Children on the Autism Spectrum from the U.S. and India","authors":"Suma Suswaram,&nbsp;Kristen Muller","doi":"10.1002/aur.70033","DOIUrl":"10.1002/aur.70033","url":null,"abstract":"<div>\u0000 \u0000 <p>We aimed to examine the interrelations between motor and communication skills, as well as associations between motor skill subdomains and different communicative functions in minimally speaking children on the autism spectrum, whereas accounting for the child's age, country of residence, educational setting, and communication modalities (covariates). Data from 67 minimally speaking children on the autism spectrum (ages 4–9) from India and the U.S. were analyzed. Motor and communication skills were assessed using the Vineland Adaptive Behavior Scales–Third Edition and the Communication Matrix. Linear regression was used to examine associations between communication and motor skills, and partial correlations were conducted to explore relations between motor skill subdomains and communicative functions. Motor skills were significantly associated with communication skills, independent of covariates. Significant relations were also observed between both motor skill subdomains and refusal functions, as well as between gross motor skills and the obtain function. No significant associations were found between social or information functions and any motor skill subdomain, independent of covariates. The findings underscore the complex and interrelated nature of motor and communication skills. Consideration of both motor and communication skills in intervention approaches may provide insights into ways to support communication development in minimally speaking children on the autism spectrum.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 6","pages":"1206-1216"},"PeriodicalIF":5.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is Distinctive About Autism Arising Following Severe Institutional Deprivation? A Direct Comparison With a Community Sample of Early Diagnosed Autistic People","authors":"Maria Rodriguez-Perez,&nbsp;Susie Chandler,&nbsp;Mark Kennedy,&nbsp;Tony Charman,&nbsp;Emily Simonoff,&nbsp;Edmund Sonuga-Barke","doi":"10.1002/aur.70026","DOIUrl":"10.1002/aur.70026","url":null,"abstract":"<p>In the English and Romanian Adoptees study, a substantial proportion of adoptees who suffered extended severe deprivation (26 of 101) displayed autistic characteristics termed quasi-autism (QA). Here we directly compare this group with a community sample of early diagnosed autistic individuals (community autism; CA). First, we characterized the QA autism symptom profile (61.5% females) by calculating which of the 32 Social Communication Questionnaire (SCQ) items were statistically more common in the QA group than in a control group of 52 non-deprived UK adoptees (UK Control, 34.6% females) at ages 11, 15, and/or 23 years of age. The latent structure of these QA-characteristic items was explored using confirmatory factor analyses. Second, we compared the QA symptom profiles with CA profiles using a sample from the QUEST study (Salazar et al. 2015). To do this, we identified two QUEST groups, one aged 11 years on average (<i>n</i> = 21) and one aged 15 years (<i>n</i> = 24). The former were compared to ERA SCQ scores at age 11, and the latter at age 15. Nineteen SCQ items were statistically significantly more common in the QA group than in the ERA UK control group at ages 11 and 15. Ten differences persisted into adulthood. These QA-characteristic items ranged across and mapped onto all three standard SCQ domains (social reciprocity, communication, repetitive and stereotyped behaviors). The age 11 CA group scored higher than QA at 11 years across each subscale when all items were considered. However, when only QA-characteristic items were included, only scores for the Repetitive and Stereotyped subscale differentiated QA and CA. When the age 15 comparison was made, no differences were found between CA and QA subscales. QA and CA were associated with similar levels of emotional and conduct problems and overactivity/inattention levels. QA shared many features with CA. QA difficulties extended across all autism domains and were associated to a similar degree with emotional and behavioral problems. However, there were some distinctive elements. Compared to the classic autism profile, the communication domain mainly comprised persistent abnormalities of linguistic expression. In contrast, social reciprocity problems were diffuse, less severe, and declined over time. QA-characteristic repetitive and stereotyped behaviors are broadly expressed and endure into adulthood.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 5","pages":"1062-1076"},"PeriodicalIF":5.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household Income, Maternal Allostatic Load During Pregnancy, and Offspring With Autism Spectrum Disorders","authors":"Shuhei Terada,&nbsp;Shoji F. Nakayama,&nbsp;Takeo Fujiwara,&nbsp;The Japan Environment and Children's Study Group","doi":"10.1002/aur.70022","DOIUrl":"10.1002/aur.70022","url":null,"abstract":"<p>Relative maternal poverty is a suggested social determinant of autism spectrum disorders (ASDs) in offspring; however, this association may be confounded by the maternal broader autism phenotype (BAP). The biological mechanisms underlying this association are largely understudied. We examined the association between household income during pregnancy and ASDs in offspring, adjusting for confounders including maternal BAP, and explored whether maternal chronic stress, measured by allostatic load (AL) during pregnancy, mediates this association. Data on 59,998 mother–child dyads were obtained from the Japan Environment and Children's Study, a nationwide birth cohort. Household income was categorized into tertiles (&lt; 4 million, 4–6 million, &gt; 6 million JPY) and offspring ASD diagnosis by age four was assessed via guardian's report. Bayesian logistic regression models indicated that mothers from low- and middle-income households had a 58% (95% credible interval [CI]: 28%–98%) and a 37% (95% CI: 12%–70%) higher risk of offspring ASDs, respectively, compared to those from high-income households. AL, defined as three or more out of 10 biomarkers in the highest risk quartile, did not mediate these associations. Low and middle household income during pregnancy was associated with a higher risk of ASD diagnosis, and high AL did not mediate this association.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 4","pages":"881-890"},"PeriodicalIF":5.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying and Responding to Gaps in the Academic Research Pipeline: Findings From the International Society for Autism Research (INSAR) Early Career Committee","authors":"Michele E. Villalobos,&nbsp;Giacomo Vivanti,&nbsp;Subhashini Jayanath,&nbsp;Kimberly Carpenter,&nbsp;Mark D. Shen,&nbsp;Frederick Shic,&nbsp;Jill Locke","doi":"10.1002/aur.70028","DOIUrl":"10.1002/aur.70028","url":null,"abstract":"<p>The International Society for Autism Research (INSAR) was established in 2001 with the purpose of providing researchers in the field of autism a specific venue to enhance the quality of multidisciplinary research and elevate the field among the sciences. The autism field and size of the society has now expanded greatly to include over 5000 members, 29% of whom identify as early career researchers. In 2016, a survey was conducted with these early career researchers to identify existing supports and areas of need necessary for a successful and sustained autism research career. Results clearly identified three areas of need: (1) networking opportunities with “change makers,” including funding agencies, journal editors, and senior autism researchers; (2) ensuring early career researchers in the autism research field were diverse and representative of the world; and (3) support from senior researchers to help early career researchers secure their first independent grant and move through promotion. The INSAR Early Career Committee (ECC) was established and developed three initiatives to address the aforementioned gaps: Research Rapid Rounds, the Global Representatives Initiative Pilot (GRIP), and the Mentoring Initiative. The ECC has successfully connected over 34 early career researchers and 40 students/trainees to mentors in 19 unique countries through networking programs and events and has established representatives in seven different countries outside the US and UK. These initiatives are a step towards supporting early career academics in the autism field and bring together autism researchers from around the world to share their work and create professional collaborations to forge our field forward.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 4","pages":"717-724"},"PeriodicalIF":5.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autistic Traits and Emotion Dysregulation in 5–11-Year-Old Intellectually Able Children With Autism Spectrum Condition: Mediating Role of Emotion Regulation Strategies","authors":"Hsin-Hui Lu,&nbsp;Angana Nandy,&nbsp;Hsing-Chang Ni","doi":"10.1002/aur.70027","DOIUrl":"10.1002/aur.70027","url":null,"abstract":"<p>Emotion dysregulation (ED) is common among children with an autism spectrum condition (ASC). However, the mechanisms underlying emotion regulation strategies (ERSs) and their impacts on ED in this population remain unclear. The current study examined whether ED is directly related to autistic traits or mediated by deficits in ERSs after comorbidity is accounted for. A cohort of 110 intellectually able children aged 5–11 years with ASC participated in this study. Autistic traits and ED were assessed using the Autism Spectrum Quotient-Children and Child Behavior Checklist, respectively. Intrinsic ERSs, specifically cognitive reappraisal and expressive suppression, were evaluated using the Parent Emotion Regulation Questionnaire, alongside items measuring parental coregulation as an extrinsic ERS. After adjusting for comorbidities (i.e., other neurodevelopmental or neurological disorders), the findings revealed pronounced autistic traits in social skills, attention switching, communication, and imagination correlated with higher ED levels, with parental coregulation mediating this correlation. Notably, the effects of communication and imagination on ED were fully mediated by parental coregulation. Additionally, autistic traits related to imagination were demonstrated to impair the development of cognitive reappraisal, further exacerbating ED. These results provide a deeper understanding of the emotional challenges faced by intellectually able children with ASC. The findings of this study underscore the importance of interventions aimed at enhancing emotion regulation within the parent–child dyad and fostering the development of cognitive reappraisal through imitative tasks. Such ERS-focused interventions hold potential for mitigating the adverse effects of autistic traits on emotional functioning.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 5","pages":"1050-1061"},"PeriodicalIF":5.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Related Trajectories of Autistic Traits in Children With Angelman Syndrome","authors":"Doesjka A. Hagenaar,&nbsp;Sabine E. Mous,&nbsp;Leontine W. ten Hoopen,&nbsp;André B. Rietman,&nbsp;Kamil R. Hiralal,&nbsp;Karen G. C. B. Bindels-de Heus,&nbsp;Pieter F. A. de Nijs,&nbsp;Theresa C. Mohr,&nbsp;Eline J. Lens,&nbsp;Manon H. J. Hillegers,&nbsp;Henriette A. Moll,&nbsp;Marie-Claire Y. de Wit,&nbsp;Gwen C. Dieleman","doi":"10.1002/aur.70017","DOIUrl":"10.1002/aur.70017","url":null,"abstract":"<p>Angelman syndrome (AS) is a rare neurogenetic disorder. Previous studies indicate a high prevalence of autism spectrum disorder (ASD) with considerable variability. Little is known regarding the longitudinal trajectory of autistic traits. We aim to investigate autistic traits, the effect of age on these traits, and associated features in AS children. This (partly) longitudinal clinical record study at the ENCORE Expertise Center involved 107 AS children aged 2–18 with one (<i>N</i> = 107), two (<i>N</i> = 49), or three (<i>N</i> = 14) measurements. Autistic traits and sensory processing issues were assessed using various instruments, and DSM classifications were used descriptively. Covariates were genotype, gender, and epilepsy. Results indicate a high prevalence of autistic traits and sensory processing issues. Children with the deletion genotype exhibited more autistic traits. Autism Diagnostic Observation Schedule (ADOS) classifications indicated higher rates of ASD compared to clinician DSM classifications. Autistic traits generally remained stable over time, except that ADOS scores significantly decreased for children with the <i>UBE3A</i> mutation genotype, and in the social affect domain for the entire group. In conclusion, incorporating the assessment of autistic traits and sensory processing into clinical practice for AS is important to inform adaptations of the environment to meet the child’s needs. Additionally, clinicians and researchers should be mindful of the potential for overestimating ASD traits in AS when relying on the ADOS. ASD diagnosis in AS should integrate multiple diagnostic instruments, diverse hetero-anamnestic sources, and multidisciplinary expert opinions.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 4","pages":"870-880"},"PeriodicalIF":5.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of Thematic and Taxonomic Relations During Lexical-Semantic Processing in Autistic Children: Evidence From Eye Movements","authors":"Zihui Hua,&nbsp;Tianbi Li,&nbsp;Ruoxi Shi,&nbsp;Ran Wei,&nbsp;Li Yi","doi":"10.1002/aur.70023","DOIUrl":"10.1002/aur.70023","url":null,"abstract":"<div>\u0000 \u0000 <p>This study investigated the activation of thematic and taxonomic relations during online lexical-semantic processing in autistic children using an eye-tracking competition task. Thirty-six preschool-aged autistic children and 35 age-, gender-, and verbal-IQ-matched neurotypical (NT) children viewed arrays containing a target object, a thematically related competitor, a taxonomically related competitor, and an unrelated distractor while hearing the target word. Results revealed three key findings. First, both groups demonstrated activation of thematic and taxonomic relations during lexical processing, with comparable timing of activation onset. Second, while autistic children began to systematically orient attention to the target as quickly as NT children, they showed reduced overall attention to the target during lexical processing. Third, autistic children exhibited stronger activation of taxonomic relations and stronger taxonomic competition effects on target recognition compared to NT children, whereas their activation of thematic relations and thematic competition effects were comparable to NT children. These findings suggest that while the basic thematic and taxonomic activation processes remain robust in autistic children, and while their initial activation of the target and semantically related representations is as fast as that of NT children, the increased sensitivity to taxonomic relations in autistic children might interfere with the overall processing efficiency of target words. These results advance our understanding of lexical-semantic organization and processing in autism and provide implications for language intervention strategies.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 5","pages":"1037-1049"},"PeriodicalIF":5.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Postural Control Variability and Coordination Persist Into Middle and Older Adulthood in Autism Spectrum Disorder","authors":"Hang Qu,&nbsp;Jingying Wang,&nbsp;Desirae J. Shirley,&nbsp;Hanna M. Gemmell,&nbsp;Danielle Christensen,&nbsp;Ann-Marie Orlando,&nbsp;Regilda A. Romero,&nbsp;Brandon A. Zielinski,&nbsp;Zheng Wang","doi":"10.1002/aur.70024","DOIUrl":"10.1002/aur.70024","url":null,"abstract":"<p>Postural control deviations remain largely unexplored in middle aged and older autistic adults. With the increased prevalence of neurodegenerative conditions and heightened fall risk, precise quantification of postural variability and coordination may provide valuable insights into aging associated neuromotor deviations in autistic adults. Forty-seven autistic and 48 non-autistic individuals completed static stance, anterior–posterior (AP), and mediolateral (ML) postural sway on a force platform. Center of pressure (COP) metrics were derived and interpreted using ANCOVAs for between-group comparisons and multilinear regressions for group <span></span><math>\u0000 \u0000 <semantics>\u0000 \u0000 <mrow>\u0000 \u0000 <mo>×</mo>\u0000 </mrow>\u0000 </semantics>\u0000 </math> age interaction. Correlations between clinical measures and COP variables that differentiated groups were explored. Compared to non-autistic individuals, autistic adults exhibited greater COP standard deviation (COP_SD) and COP trajectory length during static stance and demonstrated significant COP_SD-AP reductions in older age. Autistic adults also exhibited decreased COP range of motion (ROM) but increased ROM variability in the target direction during dynamic stance. Autistic adults' postural sway was jerkier during dynamic stance, and increased ROM variability during dynamic AP sway was moderately associated with lower verbal IQ in autistic adults. Our findings highlight persistent postural control deviations in middle aged and older autistic adults. Static and dynamic stance are differentially associated with unique profiles of postural control in ASD. Specifically, autistic adults demonstrated pronounced increases in postural sway variability during static stance, while reducing coordination during dynamic conditions. The extent to which postural control deviations found in autistic adults are predictive to the onset of neurodegenerative conditions and the severity of falls warrants future longitudinal research.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 4","pages":"752-764"},"PeriodicalIF":5.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}