通过调节肠道微生物群改善自闭症谱系障碍儿童胃肠道症状:一项系统综述和荟萃分析

IF 5.6 2区 医学 Q1 BEHAVIORAL SCIENCES
Autism Research Pub Date : 2025-07-22 DOI:10.1002/aur.70091
Hsuan-Hsuan Lu, Ngan Thi Kim Nguyen, Roma Panwar, Ching-I Lin, Tzu-Wen L. Cross, Shyh-Hsiang Lin
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引用次数: 0

摘要

患有自闭症谱系障碍(ASD)的儿童表现出高患病率(55%)的胃肠道症状(GISs)和肠道生态失调。大多数涉及ASD儿童的研究都集中在行为症状上,而不是GISs。本系统综述和荟萃分析研究了肠道微生物调节干预(GMMIs)对ASD儿童GISs和肠道微生物组成的影响。检索自数据库建立至2024年7月15日发表的国内外相关文章。荟萃分析包括接受益生元、益生菌、合成菌或粪便微生物群移植的ASD儿童的人体试验。采用α-多样性测量干预效果,采用随机效应模型和森林样地分析属和门水平数据。本研究包括19项试验(n = 1154)。结果显示,GMMIs显著改善GISs (p = 0.0017),使胃肠道症状指数6项评分降低1.86分(p = 0.0187),显著增加双歧杆菌的相对丰度(p = 0.0205)。较长的干预(≥8周)在改善GISs方面更有效。本研究的局限性包括纳入的研究既没有纳入任何饮食对照组,也没有收集相关的饮食数据,而且样本量相对较小(19项研究)可能阻碍了对汇总结果异质性来源的识别。总的来说,我们的研究结果表明,GMMIs,特别是益生菌,通过调节肠道微生物组成,特别是通过增加双歧杆菌的相对丰度,改善ASD儿童的GISs,这些干预措施可能减轻便秘、腹泻、大便一致性和气味异常、肠胃胀气和腹痛等症状。我们的证据支持可以考虑对ASD儿童使用gmmi进行治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ameliorating Gastrointestinal Symptoms in Children With Autism Spectrum Disorder by Modulating the Gut Microbiota: A Systematic Review and Meta-Analysis

Children with autism spectrum disorder (ASD) exhibit a high prevalence (55%) of gastrointestinal symptoms (GISs) and gut dysbiosis. Most studies involving children with ASD have focused on behavioral symptoms but not GISs. This systematic review and meta-analysis investigated the effects of gut microbiota–modulating interventions (GMMIs) on GISs and gut microbial composition in children with ASD. Five databases were searched for relevant domestic and international articles published from database inception until July 15, 2024. The meta-analysis included human trials wherein children with ASD received prebiotics, probiotics, synbiotics, or fecal microbiota transplantation. Intervention effects were measured on the basis of α-diversity, and genus- and phylum-level data were analyzed using a random-effects model and forest plots. This study included 19 trials (n = 1154). The results indicated that GMMIs significantly ameliorated GISs (p = 0.0017), reduced six-item Gastrointestinal Symptom Index scores by 1.86 points (p = 0.0187), and significantly increased the relative abundance of Bifidobacterium spp. (p = 0.0205). Longer interventions (≥ 8 weeks) were more effective in ameliorating GISs. Limitations in this investigation include the fact that the included studies neither incorporated any dietary control groups nor collected relevant dietary data, and the relatively small sample size (19 studies) may have hindered the identification of sources of heterogeneity in the pooled results. Overall, our findings suggest that GMMIs, especially probiotics, ameliorate GISs in children with ASD by modulating gut microbial composition, particularly by increasing the relative abundance of Bifidobacterium spp. These interventions may alleviate symptoms such as constipation, diarrhea, abnormal stool consistency and smell, flatulence, and abdominal pain. Our evidence supports that treatments involving GMMIs can be considered for children with ASD.

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来源期刊
Autism Research
Autism Research 医学-行为科学
CiteScore
8.00
自引率
8.50%
发文量
187
审稿时长
>12 weeks
期刊介绍: AUTISM RESEARCH will cover the developmental disorders known as Pervasive Developmental Disorders (or autism spectrum disorders – ASDs). The Journal focuses on basic genetic, neurobiological and psychological mechanisms and how these influence developmental processes in ASDs.
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