经颅直流电刺激治疗自闭症谱系障碍的颞顶连接:一项随机、双盲、假对照可行性研究的结果。

IF 5.6 2区 医学 Q1 BEHAVIORAL SCIENCES
Autism Research Pub Date : 2025-07-16 DOI:10.1002/aur.70084
Christina Luckhardt, Magdalena Schütz, Andreas M. Mühlherr, Sara Boxhoorn, Christine Ecker, Hanna Mössinger, Julia Siemann, Fabienne Schlechter, Miguel Castelo-Branco, Helena C. Pereira, Marianne Latinus, Camille Ricou, Frederique Bonnet-Brilhault, Ricardo Salvador, Giulio Ruffini, Rafal Nowak, Michael Siniatchkin, Astrid Dempfle, Christine M. Freitag
{"title":"经颅直流电刺激治疗自闭症谱系障碍的颞顶连接:一项随机、双盲、假对照可行性研究的结果。","authors":"Christina Luckhardt,&nbsp;Magdalena Schütz,&nbsp;Andreas M. Mühlherr,&nbsp;Sara Boxhoorn,&nbsp;Christine Ecker,&nbsp;Hanna Mössinger,&nbsp;Julia Siemann,&nbsp;Fabienne Schlechter,&nbsp;Miguel Castelo-Branco,&nbsp;Helena C. Pereira,&nbsp;Marianne Latinus,&nbsp;Camille Ricou,&nbsp;Frederique Bonnet-Brilhault,&nbsp;Ricardo Salvador,&nbsp;Giulio Ruffini,&nbsp;Rafal Nowak,&nbsp;Michael Siniatchkin,&nbsp;Astrid Dempfle,&nbsp;Christine M. Freitag","doi":"10.1002/aur.70084","DOIUrl":null,"url":null,"abstract":"<p>Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham-controlled, double-blind parallel-group Phase-IIa trial, we investigated feasibility, safety, and effect sizes of 10 sessions of anodal tDCS of the bilateral TPJ at 2 mA as an add-on to computer-based social cognitive training in 10- to 17-year-old youth with autism. Feasibility of recruitment was low, with only 11% of screened individuals being randomized to tDCS (<i>N</i> = 12) or sham (<i>N</i> = 12). In contrast, retention in the study, data collection, intervention adherence, and technical feasibility were mostly excellent. No serious adverse events occurred, and stimulation was well tolerated. There were no differences in the prespecified primary outcome social responsiveness between sham and tDCS immediately after the intervention (standardized estimated effect size [ES] = 0.098; 95%-confidence interval [95% CI] −1.043;1.240), but the sham group showed a trend for better social responsiveness at the 4 week follow-up (ES = 1.106; 95% CI −0.054; 2.270). Secondary outcomes including questionnaires and event-related potentials showed improved compulsive behavior and quality of life by tDCS. High technical feasibility, participant retention, and safety highlight the potential of tDCS in autism and may inform future improvements in the feasibility of recruitment. The differential pattern of effect estimates indicates positive, but also potential negative effects of tDCS, which may vary due to tDCS stimulation parameters. The trial was prospectively registered in the German Clinical Trials Register (Deutsches Register für klinische Studien, DRKS, DRKS00014732).</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 9","pages":"1861-1876"},"PeriodicalIF":5.6000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442529/pdf/","citationCount":"0","resultStr":"{\"title\":\"Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study\",\"authors\":\"Christina Luckhardt,&nbsp;Magdalena Schütz,&nbsp;Andreas M. Mühlherr,&nbsp;Sara Boxhoorn,&nbsp;Christine Ecker,&nbsp;Hanna Mössinger,&nbsp;Julia Siemann,&nbsp;Fabienne Schlechter,&nbsp;Miguel Castelo-Branco,&nbsp;Helena C. Pereira,&nbsp;Marianne Latinus,&nbsp;Camille Ricou,&nbsp;Frederique Bonnet-Brilhault,&nbsp;Ricardo Salvador,&nbsp;Giulio Ruffini,&nbsp;Rafal Nowak,&nbsp;Michael Siniatchkin,&nbsp;Astrid Dempfle,&nbsp;Christine M. Freitag\",\"doi\":\"10.1002/aur.70084\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham-controlled, double-blind parallel-group Phase-IIa trial, we investigated feasibility, safety, and effect sizes of 10 sessions of anodal tDCS of the bilateral TPJ at 2 mA as an add-on to computer-based social cognitive training in 10- to 17-year-old youth with autism. Feasibility of recruitment was low, with only 11% of screened individuals being randomized to tDCS (<i>N</i> = 12) or sham (<i>N</i> = 12). In contrast, retention in the study, data collection, intervention adherence, and technical feasibility were mostly excellent. No serious adverse events occurred, and stimulation was well tolerated. There were no differences in the prespecified primary outcome social responsiveness between sham and tDCS immediately after the intervention (standardized estimated effect size [ES] = 0.098; 95%-confidence interval [95% CI] −1.043;1.240), but the sham group showed a trend for better social responsiveness at the 4 week follow-up (ES = 1.106; 95% CI −0.054; 2.270). Secondary outcomes including questionnaires and event-related potentials showed improved compulsive behavior and quality of life by tDCS. High technical feasibility, participant retention, and safety highlight the potential of tDCS in autism and may inform future improvements in the feasibility of recruitment. The differential pattern of effect estimates indicates positive, but also potential negative effects of tDCS, which may vary due to tDCS stimulation parameters. The trial was prospectively registered in the German Clinical Trials Register (Deutsches Register für klinische Studien, DRKS, DRKS00014732).</p>\",\"PeriodicalId\":131,\"journal\":{\"name\":\"Autism Research\",\"volume\":\"18 9\",\"pages\":\"1861-1876\"},\"PeriodicalIF\":5.6000,\"publicationDate\":\"2025-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442529/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Autism Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/aur.70084\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BEHAVIORAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autism Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/aur.70084","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

自闭症谱系障碍(ASD)在社会认知任务中减少了颞顶连接(TPJ)的激活。因此,经颅直流电刺激(tDCS)可以提高自闭症患者的社会认知能力。在一项多中心、随机、假对照、双盲平行组iia期试验中,我们对10- 17岁的自闭症青少年在2 mA时进行双侧TPJ阳极tDCS作为基于计算机的社会认知训练的附加训练的可行性、安全性和效应量进行了研究。招募的可行性很低,只有11%的筛选个体被随机分配到tDCS (N = 12)或假手术(N = 12)。相比之下,研究中的保留、数据收集、干预依从性和技术可行性大多很好。未发生严重不良事件,刺激耐受良好。干预后,假手术和tDCS在预先指定的主要结果社会反应性方面没有差异(标准化估计效应量[ES] = 0.098;95%可信区间[95% CI] -1.043;1.240),但假手术组在4周随访时表现出更好的社会反应趋势(ES = 1.106;95% ci -0.054;2.270)。包括问卷调查和事件相关电位在内的次要结果显示,tDCS改善了强迫行为和生活质量。高技术可行性、参与者保留率和安全性突出了tDCS在自闭症中的潜力,并可能为未来招募可行性的改进提供信息。效应估计的差异模式表明了tDCS的积极影响,但也表明了潜在的负面影响,这些影响可能因tDCS刺激参数而异。该试验已在德国临床试验注册(Deutsches Register f r klinische studen, DRKS, DRKS00014732)进行前瞻性注册。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study

Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study

Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham-controlled, double-blind parallel-group Phase-IIa trial, we investigated feasibility, safety, and effect sizes of 10 sessions of anodal tDCS of the bilateral TPJ at 2 mA as an add-on to computer-based social cognitive training in 10- to 17-year-old youth with autism. Feasibility of recruitment was low, with only 11% of screened individuals being randomized to tDCS (N = 12) or sham (N = 12). In contrast, retention in the study, data collection, intervention adherence, and technical feasibility were mostly excellent. No serious adverse events occurred, and stimulation was well tolerated. There were no differences in the prespecified primary outcome social responsiveness between sham and tDCS immediately after the intervention (standardized estimated effect size [ES] = 0.098; 95%-confidence interval [95% CI] −1.043;1.240), but the sham group showed a trend for better social responsiveness at the 4 week follow-up (ES = 1.106; 95% CI −0.054; 2.270). Secondary outcomes including questionnaires and event-related potentials showed improved compulsive behavior and quality of life by tDCS. High technical feasibility, participant retention, and safety highlight the potential of tDCS in autism and may inform future improvements in the feasibility of recruitment. The differential pattern of effect estimates indicates positive, but also potential negative effects of tDCS, which may vary due to tDCS stimulation parameters. The trial was prospectively registered in the German Clinical Trials Register (Deutsches Register für klinische Studien, DRKS, DRKS00014732).

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Autism Research
Autism Research 医学-行为科学
CiteScore
8.00
自引率
8.50%
发文量
187
审稿时长
>12 weeks
期刊介绍: AUTISM RESEARCH will cover the developmental disorders known as Pervasive Developmental Disorders (or autism spectrum disorders – ASDs). The Journal focuses on basic genetic, neurobiological and psychological mechanisms and how these influence developmental processes in ASDs.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信