Autism Research最新文献_第4页

Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study 自闭症谱系障碍中外祖父母的年龄、种族和民族：加州多代研究。

IF 5.6 2区医学

Autism Research Pub Date : 2025-06-20 DOI: 10.1002/aur.70074

Ting Chow, Qi Meng, Jingyuan Xiao, Karl O'Sharkey, Zeyan Liew, Beate Ritz

{"title":"Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study","authors":"Ting Chow, Qi Meng, Jingyuan Xiao, Karl O'Sharkey, Zeyan Liew, Beate Ritz","doi":"10.1002/aur.70074","DOIUrl":"10.1002/aur.70074","url":null,"abstract":"We investigated associations between maternal grandparents' age and autism spectrum disorders (ASD) in grandchildren, exploring differences by race/ethnicity. In a multigenerational California birth cohort study including 1,743,998 and 1,630,722 mother–child pairs (with 27,975 and 25,816 ASD cases, respectively), we examined ASD risk by grandmother's and grandfather's age at the time when their daughter was born. Logistic regression was used to obtain odds ratios (ORs) and 95% CIs. The odds of ASD in grandchildren were higher among White grandmothers (OR, 1.14; 95% CI, 1.08–1.20) and grandfathers (OR, 1.18; 95% CI, 1.11–1.25) who had daughters at younger ages (18–24 years) compared to the 25–29 year reference, while inverse associations were observed for younger Black grandmothers (OR, 0.85; 95% CI, 0.78–0.94). At older ages (35–55 years), ASD risks were higher among Hispanic grandmothers (OR, 1.13; 95% CI, 1.06–1.21) and Hispanic (OR, 1.12; 95% CI, 1.06–1.18) and Black grandfathers (OR, 1.18; 95% CI, 1.05–1.32). The risk of ASD in grandchildren was higher among older grandparents of several races/ethnicities but among the youngest grandparents only among those of White race. Differences by race/ethnicity may imply different mechanisms operating in younger and older grandparents. Studies exploring the contributions of biological as well as social, occupational, and environmental factors on the influence of age at pregnancy with ASD are needed.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 8","pages":"1664-1673"},"PeriodicalIF":5.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Maternal Asthma and Child Autism: A Systematic Review and Meta-Analysis 母亲哮喘与儿童自闭症之间的关系：一项系统综述和荟萃分析。

IF 5.6 2区医学

Autism Research Pub Date : 2025-06-20 DOI: 10.1002/aur.70071

Renee van der Schaaf, Vanessa E. Murphy, Soriah Harvey, Paige Dent, Alison Lane, Olivia Whalen

{"title":"The Association Between Maternal Asthma and Child Autism: A Systematic Review and Meta-Analysis","authors":"Renee van der Schaaf, Vanessa E. Murphy, Soriah Harvey, Paige Dent, Alison Lane, Olivia Whalen","doi":"10.1002/aur.70071","DOIUrl":"10.1002/aur.70071","url":null,"abstract":"Maternal asthma has been linked to child autism. In this study, we systematically reviewed observational studies published between July 2001 and February 2024 that assessed maternal asthma during pregnancy (exposure) and child autism (outcome). Databases searched included MEDLINE, CINAHL, EMBASE, and PsycINFO. Of the 350 potential studies, 19 met the inclusion criteria (2,530,716 participants; 73,065 autistic participants). Quality was assessed with the Newcastle–Ottawa Scale. Meta-analyses using proportions and odds ratios were conducted using the Mantel–Haenszel method with a random-effects model. Compared to women without asthma, there was an increased odds of child autism with any history of maternal asthma (OR = 1.32; 95% CI = 1.21, 1.44; I2 = 61%, n = 14), with current asthma during pregnancy (OR = 1.23; 95% CI = 1.12, 1.35; I2 = 35%, n = 10) and with medication use during pregnancy (OR = 1.48; 95% CI = 1.30, 1.68; I2 = 0%, n = 3). However, when women with asthma who used asthma medication were compared to those with asthma who did not use medication, there were no increased odds for child autism (OR = 1.07; 95% CI = 0.89, 1.27; I2 = 34%, n = 2). Maternal asthma is associated with an increased odds of child autism. Future studies should consider neurodivergence in the parents, the severity of asthma, and the effectiveness of prescribed medication in managing the mother's asthma to improve our understanding of this association.Trial Registration: PROSPERO registration: CRD42021265060","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 8","pages":"1630-1650"},"PeriodicalIF":5.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synaptic Deficits in Adnp-Mutant Mice Are Ameliorated by Histone Demethylase LSD1 Inhibition 抑制组蛋白去甲基化酶LSD1可改善adnp突变小鼠的突触缺陷

IF 5.3 2区医学

Autism Research Pub Date : 2025-06-19 DOI: 10.1002/aur.70069

Chih-Hung Lin, Yong Ren, Kin Wai Tam, Megan Conrow-Graham, Zhen Yan

{"title":"Synaptic Deficits in Adnp-Mutant Mice Are Ameliorated by Histone Demethylase LSD1 Inhibition","authors":"Chih-Hung Lin, Yong Ren, Kin Wai Tam, Megan Conrow-Graham, Zhen Yan","doi":"10.1002/aur.70069","DOIUrl":"10.1002/aur.70069","url":null,"abstract":"<div>\u0000 \u0000 ADNP (Activity-dependent neuroprotective protein) is a top-ranking autism risk gene. Here we examined synaptic alterations in heterozygous mice carrying an autism mutation on Adnp C-terminus (Adnpmut). We found that PFC pyramidal neurons in Adnpmut mice exhibited significantly diminished glutamatergic and GABAergic synaptic transmission, as indicated by markedly reduced excitatory postsynaptic currents (EPSC) and inhibitory postsynaptic currents (IPSC). Given the key role of ADNP in chromatin regulation and the constitutive association of the ADNP complex with lysine-specific demethylase 1 (LSD1), we examined the therapeutic effects of LSD1 inhibition in Adnpmut mice. We found that treatment with an LSD1 inhibitor significantly elevated EPSC and IPSC in PFC pyramidal neurons of Adnpmut mice, and the rescuing effect was particularly prominent in females. Biochemical assays revealed increased H3K4me2 and decreased H3K9me2/3 by LSD1 inhibitor treatment in female Adnpmut mice, which were correlated with the elevated expression of synaptic genes linked to glutamatergic and GABAergic transmission after the treatment. These data have revealed synaptic deficits in PFC induced by a loss-of-function mutation of Adnp and uncovered the therapeutic potential of LSD1 inhibition in ADNP-deficient conditions, especially for females.\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 7","pages":"1342-1355"},"PeriodicalIF":5.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive Flexibility Mediates the Associations Between Perceived Stress, Social Camouflaging and Mental Health Challenges in Autistic Adults 认知灵活性在自闭症成人感知压力、社会伪装和心理健康挑战之间起中介作用。

IF 5.6 2区医学

Autism Research Pub Date : 2025-06-03 DOI: 10.1002/aur.70061

Matthew J. Hollocks, Goldie A. McQuaid, Nancy R. Lee, Gregory L. Wallace

{"title":"Cognitive Flexibility Mediates the Associations Between Perceived Stress, Social Camouflaging and Mental Health Challenges in Autistic Adults","authors":"Matthew J. Hollocks, Goldie A. McQuaid, Nancy R. Lee, Gregory L. Wallace","doi":"10.1002/aur.70061","DOIUrl":"10.1002/aur.70061","url":null,"abstract":"Autistic people are at an elevated risk of experiencing co-occurring anxiety and depression. The contributors to this are likely multifaceted and complex and remain poorly understood. Cognitive flexibility, social camouflaging, and perceived stress provide useful indices of the interacting neurocognitive, behavioral, and environmental factors that have been associated with anxiety and depression in autistic individuals. Here, we test if cognitive flexibility, as the factor most closely related to individual differences in thinking styles, mediates the relationships between social camouflaging, perceived stress, and anxiety/depression. This study included 806 autistic individuals aged between 18 and 83 years (Mean age = 40.2), recruited through the Research Match service of the Simons Powering Autism Research (SPARK) participant registry. Participants completed an online battery of questionnaires measuring cognitive and social flexibility, social camouflaging, perceived stress, anxiety, and depression. Parallel mediation analyses were used to test the mediating effect of cognitive and social flexibility. Across separate parallel mediation analyses, cognitive flexibility was found to significantly mediate the relationships between both social camouflaging and perceived stress with anxiety and depression. This was contrasted with social flexibility, which showed a lower magnitude mediating effect for perceived stress and no mediating effect of social camouflaging. Cognitive flexibility plays an important mediating role between the impact of both perceived stress and social camouflaging on greater symptoms of both anxiety and depression in autistic adults.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 8","pages":"1595-1607"},"PeriodicalIF":5.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network Analysis of Autistic Language Learners Along the Small World Spectrum 自闭症语言学习者的小世界谱网络分析。

IF 5.6 2区医学

Autism Research Pub Date : 2025-06-02 DOI: 10.1002/aur.70065

Eileen Haebig, Stanley West, Eva Jiménez, Thomas T. Hills, Christopher R. Cox

{"title":"Network Analysis of Autistic Language Learners Along the Small World Spectrum","authors":"Eileen Haebig, Stanley West, Eva Jiménez, Thomas T. Hills, Christopher R. Cox","doi":"10.1002/aur.70065","DOIUrl":"10.1002/aur.70065","url":null,"abstract":"<div>\u0000 \u0000 Recent network analyses of vocabulary growth revealed important relationships between the structure of the semantic environment and early vocabulary acquisition in non-autistic children. However, autistic children may be less likely to encode associated features of novel objects, suggesting divergent processes for acquiring semantic information about words. We examined the expressive vocabularies of 815 non-autistic and 163 autistic children (words produced: MAutistic = 183.06, MNon-autistic = 182.91). We estimated their trajectories of semantic development using network analyses. Network structure was based on child-oriented word associations. We analyzed networks according to indegree, average shortest path length, clustering coefficient, and small-world propensity (features holistically contributing to “small-world” network structure). Analyses revealed that autistic and non-autistic children are sensitive to the structure of their semantic environment. However, group differences were observed, with an early peak in the autistic group's clustering coefficient (how closely connected groups of words are), followed by a sharp decline. Moreover, across each network metric, we found that autistic children had reduced small-world structure relative to non-autistic toddlers. Thus, group differences indicate that, although autistic children are learning from their semantic environment, they may be processing their semantic environment differently, the language input to which they are exposed differs relative to non-autistic children, or a combination of the two.\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 8","pages":"1580-1594"},"PeriodicalIF":5.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep–Wake Cycle and Circadian Misalignment in People With Autism Across the Lifespan With an Emphasis on Living Conditions 自闭症患者一生中睡眠-觉醒周期和昼夜节律失调与生活条件的关系

IF 5.3 2区医学

Autism Research Pub Date : 2025-06-02 DOI: 10.1002/aur.70058

Elena Martínez-Cayuelas, Ana María García-Muñoz, María Luisa Sánchez de Ocaña-Moreno, Amanda L. Richdale, Laura Gisbert-Gustemps, Jorge Lugo-Marín, Beatriz Rodríguez-Morillas, Ana María Peiró-Peiró, Desirée Victoria-Montesinos, Cristina López-Anguas, María Dolores Meseguer-Illán, Pura Ballester-Navarro

{"title":"Sleep–Wake Cycle and Circadian Misalignment in People With Autism Across the Lifespan With an Emphasis on Living Conditions","authors":"Elena Martínez-Cayuelas, Ana María García-Muñoz, María Luisa Sánchez de Ocaña-Moreno, Amanda L. Richdale, Laura Gisbert-Gustemps, Jorge Lugo-Marín, Beatriz Rodríguez-Morillas, Ana María Peiró-Peiró, Desirée Victoria-Montesinos, Cristina López-Anguas, María Dolores Meseguer-Illán, Pura Ballester-Navarro","doi":"10.1002/aur.70058","DOIUrl":"10.1002/aur.70058","url":null,"abstract":"<div>\u0000 \u0000 Sleep problems among individuals with autism spectrum disorder (ASD) are a persistent issue that spans from early childhood to adulthood. The present study aimed to objectively investigate sleep continuity and alignment using ambulatory circadian monitoring (ACM) in a group of autistic individuals, with and without intellectual disabilities. We studied 214 participants. Sleep continuity and alignment were assessed using a minimum of 3 days of ACM. Participants were divided into four groups: (1) age < 10 years (n = 40, 87.5% males, M = 6.78 ± 1.40 years), (2) age 10–17 years (n = 53, 90.6% males, M = 12.62 ± 2.04 years), (3) age 18–27 years (n = 59, 74.6% males, M = 23.50 ± 2.60 years), and (4) age 28–65 years (n = 62, 74.2% males, M = 39.04 ± 9.49 years). All groups had significantly impaired sleep outcomes, except for TST. Adults had longer SOL and WASO duration, than children and adolescents. However, those differences were attenuated if participants ‘percentages of sleep parameters within normal range’ were compared. When evaluating circadian misalignment, sleep M5 is delayed in children and adolescents (2:56 am and 3:00 am, respectively), and strongly advanced in the older adults (group 4). Sleep problems that manifest in autism during childhood can endure throughout adulthood. Furthermore, there is a necessity to investigate how living conditions, such as enforced schedules in residential facilities, can influence the timing of the sleep midpoint.\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 7","pages":"1369-1380"},"PeriodicalIF":5.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Daily Living Skills From Childhood and Adolescence Predictive of Adult Outcomes in a Longitudinal Study of Autism and Related Developmental Conditions 在自闭症和相关发育条件的纵向研究中，确定童年和青春期的日常生活技能对成年结局的预测。

IF 5.3 2区医学

Autism Research Pub Date : 2025-05-30 DOI: 10.1002/aur.70056

Elaine B. Clarke, Catherine Lord

{"title":"Identifying Daily Living Skills From Childhood and Adolescence Predictive of Adult Outcomes in a Longitudinal Study of Autism and Related Developmental Conditions","authors":"Elaine B. Clarke, Catherine Lord","doi":"10.1002/aur.70056","DOIUrl":"10.1002/aur.70056","url":null,"abstract":"Challenges in daily living skills (DLS) are well-documented in autism and other developmental conditions. Research has also cataloged challenges in adult outcome attainment among autistic individuals and those with other developmental conditions; stronger DLS are associated with a higher likelihood of attaining some adult outcomes. Little work has examined whether competency in specific DLS increases the likelihood of attaining adult outcomes. The current study examined mean item set scores from the DLS domain of the first and second editions of the Vineland Adaptive Behavior Scales (VABS) in a sample (n = 230) drawn from a well-characterized longitudinal cohort. Differences in growth patterns in DLS item set scores based on cognitive ability were examined from ages 5–18. The utility of DLS item set scores from ages 5, 9, 14, and 18 for predicting adult employment, relationship, living, and well-being outcomes at approximately age 33 was then tested. For all participants, DLS item sets from the community subdomain (i.e., eating out skills, pre-job skills) were low throughout childhood and showed the least growth over time. For participants with IQ < 70, personal subdomain item sets (i.e., bathing, health) had the most predictive utility. For participants with IQ > 70, community subdomain item sets had the most predictive utility. Competency in personal DLS may promote positive outcomes for autistic individuals with IQ < 70; competency in community DLS may be more important to supporting outcomes for autistic individuals with average or higher IQ. These results could inform interventions intended to promote adult success.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 7","pages":"1474-1488"},"PeriodicalIF":5.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal Touch During Mother–Infant Interactions in Infants With and Without an Elevated Likelihood for Autism: Links With Symptom-Level Difficulties of Maternal Psychological Stress 在有或没有自闭症可能性升高的婴儿中，母婴互动中的母亲触摸：与母亲心理压力的症状水平困难的联系。

IF 5.3 2区医学

Autism Research Pub Date : 2025-05-30 DOI: 10.1002/aur.70067

J. Siew, P. Warreyn, F. Moerman, T. Van Lierde, A. Zanatta, H. Roeyers

{"title":"Maternal Touch During Mother–Infant Interactions in Infants With and Without an Elevated Likelihood for Autism: Links With Symptom-Level Difficulties of Maternal Psychological Stress","authors":"J. Siew, P. Warreyn, F. Moerman, T. Van Lierde, A. Zanatta, H. Roeyers","doi":"10.1002/aur.70067","DOIUrl":"10.1002/aur.70067","url":null,"abstract":"<div>\u0000 \u0000 Infants at elevated likelihood for autism (EL infants) have varied developmental outcomes. This exposes parents to a unique parenting journey, and in some, heightened psychological stress. This study investigated how maternal psychological stress is linked to variations in mother–infant interactions, specifically touch. We focused on mothers of EL infants, including infants with an older autistic sibling and infants born preterm (< 30 weeks), as well as mothers of infants at typical likelihood for autism (TL infants). At 10 months, maternal touch was coded during mother–infant interactions (n = 100) and psychological stress was measured using the Brief Symptom Inventory (n = 108). Results showed that mothers of sibling infants (n = 44) reported higher depressive symptoms compared to mothers of TL infants (n = 22). Mothers of preterm infants (n = 39) used less affectionate and caregiving touch and had shorter total touch duration, compared to mothers of TL infants (n = 20), and to a lesser extent, mothers of sibling infants (n = 41). In addition, mothers of sibling infants exhibited more high-intensity touch than both mothers of preterm and TL infants. Notably, increased depressive symptoms were associated with decreased touch duration in mothers of sibling (n = 41) and preterm infants (n = 39) only. These findings underscore the complex relationship between maternal depressive symptoms and maternal use of touch.\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 7","pages":"1461-1473"},"PeriodicalIF":5.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective Memory Performance of Autistic Adults in Everyday Life: The Role of Stress and Motivation 自闭症成人在日常生活中的前瞻记忆表现：压力和动机的作用。

IF 5.3 2区医学

Autism Research Pub Date : 2025-05-29 DOI: 10.1002/aur.70057

Larissa L. Faustmann, Mareike Altgassen

引用次数: 0

Changes in Early Aperiodic EEG Activity Are Linked to Autism Diagnosis and Language Development in Infants With Family History of Autism 有自闭症家族史的婴儿早期非周期性脑电图活动的变化与自闭症诊断和语言发展有关

IF 5.3 2区医学

Autism Research Pub Date : 2025-05-26 DOI: 10.1002/aur.70063

Carol L. Wilkinson, Haerin Chung, Amy Dave, Helen Tager-Flusberg, Charles A. Nelson

{"title":"Changes in Early Aperiodic EEG Activity Are Linked to Autism Diagnosis and Language Development in Infants With Family History of Autism","authors":"Carol L. Wilkinson, Haerin Chung, Amy Dave, Helen Tager-Flusberg, Charles A. Nelson","doi":"10.1002/aur.70063","DOIUrl":"10.1002/aur.70063","url":null,"abstract":"<div>\u0000 \u0000 Delays in language often co-occur among toddlers diagnosed with autism. Despite the high prevalence of language delays, the neurobiology underlying such language challenges remains unclear. Prior research has shown reduced EEG power across multiple frequency bands in 3-to-6-month-old infants with an autistic sibling, followed by accelerated increases in power with age. In this study, we decompose the power spectra into aperiodic (broad band neural firing) and periodic (oscillations) activity to explore possible links between aperiodic changes in the first year of life and later language outcomes. Combining EEG data across two longitudinal studies of infants with and without autistic siblings, we assessed whether infants with an elevated familial likelihood (EFL) exhibit altered changes in both periodic and aperiodic EEG activity at 3 and 12 months of age, compared to those with a low likelihood (LL), and whether developmental change in activity is associated with language development. At 3 months of age (n = LL 59, EFL 57), we observed that EFL infants have significantly lower aperiodic activity from 6.7 to 55 Hz (p < 0.05). However, change in aperiodic activity from 3 to 12 months was significantly increased in infants with a later diagnosis of autism, compared to EFL infants without an autism diagnosis (n = LL-NoASD 41, EFL-noASD 16, EFL-ASD 16). In addition, greater increases in aperiodic offset and slope from 3 to 12 months were associated with worse language development measured at 18 months (n = 24). Findings suggest that early age-dependent changes in EEG aperiodic power may serve as potential indicators of autism and language development in infants with a family history of autism.\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 7","pages":"1356-1368"},"PeriodicalIF":5.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0