Acta Oto-Laryngologica最新文献

Global incidence, standardized mortality ratio, and risk factors for suicide in head and neck cancer versus other cancer population: a systematic review and meta-analysis. 头颈癌与其他癌症人群的全球发病率、标准化死亡率和自杀风险因素：系统回顾和荟萃分析

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-06-03 DOI: 10.1080/00016489.2025.2507695

Srivatsa Surya Vasudevan, Victor Albornoz Alvarez, Sydney Schwab, Lindsay Olinde, Cherie-Ann O Nathan

{"title":"Global incidence, standardized mortality ratio, and risk factors for suicide in head and neck cancer versus other cancer population: a systematic review and meta-analysis.","authors":"Srivatsa Surya Vasudevan, Victor Albornoz Alvarez, Sydney Schwab, Lindsay Olinde, Cherie-Ann O Nathan","doi":"10.1080/00016489.2025.2507695","DOIUrl":"https://doi.org/10.1080/00016489.2025.2507695","url":null,"abstract":"Background: Suicide incidence and risk factors in head and neck cancer (HNC) vary across studies.Objective: To evaluate suicide incidence, standardized mortality ratio (SMR), and predictors in HNC versus other cancers.Material and methods: PubMed, Embase, ScienceDirect, and Web of Science were systematically reviewed until February 2025. A random-effects meta-analysis assessed the outcomes.Results: Out of 1,186 screened articles, 21 studies with 33,768,815 cancer patients (HNC: 2,470,243; non-HNC: 31,298,572) were included (mean age: 66.1 ± 8.82 years). The pooled suicide incidence in HNC was 277.1 per 100,000 (95% CI: 217.5-336.6), the highest among cancer populations, with Asia reporting the highest rate (457.9 per 100,000). The standardized mortality ratio (SMR) for suicide in HNC was 2.62 (95% CI: 2.10-3.26, p < 0.0001), ranking fourth among tumors. Risk factors included age ≥65 years (HR = 1.07, p = 0.03), male gender (HR = 5.55, p < 0.0001), distant metastases (HR = 1.47, 95% CI: 1.14-1.90, p = 0.003), and regional spread (HR = 1.28, p = 0.03).Conclusion: HNC had the highest suicide incidence and ranked fourth in SMR among cancers. Our meta-analysis identified key positive and negative suicide predictors.Significance: This meta-analysis provides the current incidence and SMR statistics in HNC compared to the non-HNC population.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic impact of p16 and HPV discordance in cancer of unknown primary: a systematic review and meta-analysis. p16和HPV不一致对未知原发癌预后的影响：一项系统综述和荟萃分析。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-31 DOI: 10.1080/00016489.2025.2509655

Clara H Pinborg, Amanda-Louise F Carlander, Joachim Hansen, Christian Grønhøj, Kathrine K Jakobsen, Christian von Buchwald

{"title":"Prognostic impact of p16 and HPV discordance in cancer of unknown primary: a systematic review and meta-analysis.","authors":"Clara H Pinborg, Amanda-Louise F Carlander, Joachim Hansen, Christian Grønhøj, Kathrine K Jakobsen, Christian von Buchwald","doi":"10.1080/00016489.2025.2509655","DOIUrl":"https://doi.org/10.1080/00016489.2025.2509655","url":null,"abstract":"Background: Discordance between human papillomavirus (HPV) and its surrogate marker, p16INK4a (p16), raises concerns about the reliability of p16 as a sole prognostic marker.Objectives: To investigate the impact of HPV, p16, and discordant HPV/p16 status on survival in squamous cell carcinoma of unknown primary in the head and neck (SCCUPHN).Materials and methods: PubMed and EMBASE were searched for relevant studies that used a strict definition of SCCUPHN and reported survival outcomes stratified by HPV/p16 status. A meta-analysis assessed the prevalence and overall survival (OS).Results: Twelve studies (n = 864) were included. The pooled prevalence rates were: 23% HPV+/p16+ SCCUPHN (95% CI: 14-33%); 50% HPV-/p16- (95% CI: 32-67%); 13% HPV-/p16+ (95% CI: 6-19%); and 6% HPV+/p16- (95% CI: 1-10%). OS hazard ratios were: 0.37 (95% CI: 0.17-0.78) for p16+ vs. p16-, 0.35 (95% CI: 0.19-0.64) for HPV+ vs. HPV-, and 0.24 (95% CI: 0.12-0.50) for HPV+/p16+ vs. HPV-/p16-. Only one study (n = 103) compared survival in the four HPV/p16 subgroups individually.Conclusions: HPV and p16 are individual positive prognostic markers in SCCUPHN. Although significant discordance exists, the current literature does not provide sufficient evidence to support risk stratifying SCCUPHN patients into four distinct HPV/p16 subgroups.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between mastoid pneumatization and antrochoanal polyps in pediatric patients. 小儿乳突充气与鼻后鼻息肉的关系。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-27 DOI: 10.1080/00016489.2025.2510503

Gamze Ozturk Yilmaz, Gokhan Yilmaz, Nevfel Kahvecioglu, Erdem Atalay Cetinkaya, Omer Tarik Selcuk, Ozer Erdem Gur, Hulya Eyigor

{"title":"Association between mastoid pneumatization and antrochoanal polyps in pediatric patients.","authors":"Gamze Ozturk Yilmaz, Gokhan Yilmaz, Nevfel Kahvecioglu, Erdem Atalay Cetinkaya, Omer Tarik Selcuk, Ozer Erdem Gur, Hulya Eyigor","doi":"10.1080/00016489.2025.2510503","DOIUrl":"https://doi.org/10.1080/00016489.2025.2510503","url":null,"abstract":"Background: Mastoid pneumatization reflects middle ear aeration and may be disrupted in chronic inflammatory conditions such as Antrochoanal polyps (AP), potentially predisposing children to otologic complications.Objective: We aimed to investigate the developmental relationship between AP volume and total mastoid air cell volume (TMCV).Methods: The correlation between the volume of nasal polyps and TMCV was assessed in 21 pediatric patients with AP. TMCV on the side not affected by AP served as the control within each patient. Polyp volume and TMCV were quantified using computed tomography (CT)-based 3D reconstruction.Results: The mean TMCV on the side with AP was 7.68 ± 6.13 cm³, while the mean TMCV on the contralateral side was 8.44 ± 6.67 cm³. This difference was statistically significant (p = 0.042). However, no statistically significant correlation was observed between polyp volume and TMCV on the affected side (p = 0.758).Conclusion: Our results suggest that AP may have a negative effect on mastoid pneumatization. Further research with larger cohorts is warranted.Significance: These findings highlight the need for comprehensive radiologic evaluation in children with AP to monitor potential mastoid involvement.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-4"},"PeriodicalIF":1.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of age on hearing outcomes following stapes surgery for otosclerosis: a retrospective study. 年龄对耳硬化镫骨手术后听力结果的影响：一项回顾性研究

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-27 DOI: 10.1080/00016489.2025.2504040

Na Zhang, Xiaobo Ma, Danni Wang, Yi Li, Yan Zheng, Yongxin Li, Shouqin Zhao

{"title":"Impact of age on hearing outcomes following stapes surgery for otosclerosis: a retrospective study.","authors":"Na Zhang, Xiaobo Ma, Danni Wang, Yi Li, Yan Zheng, Yongxin Li, Shouqin Zhao","doi":"10.1080/00016489.2025.2504040","DOIUrl":"https://doi.org/10.1080/00016489.2025.2504040","url":null,"abstract":"Background: Otosclerosis causes progressive hearing loss, with stapes surgery being the most effective treatment. However, the influence of age on postoperative outcomes remains debated.Objective: To evaluate the impact of age on hearing outcomes following stapes surgery.Methods: This retrospective study included patients who underwent primary stapes surgery (2010-2024), excluding those with revision surgeries or confirmed cochlear otosclerosis. Pre- and postoperative pure-tone audiometry assessed air conduction (AC), bone conduction (BC), and air-bone gap (ABG) across age groups.Results: This study included 177 patients (188 ears) aged 18-68 years. Significant improvements in AC thresholds and ABG closure were observed across all age groups (p < 0.05). BC thresholds improved significantly in patients <50 years. Linear regression revealed a modest negative correlation between age and AC improvement (R2 = 0.18, p = 0.006). Despite smaller gains in older patients, both age groups demonstrated substantial improvements AC thresholds and ABG, with minimal changes in BC thresholds. No significant differences were found between younger and older groups in changes in BC, AC, or ABG closure (all p > 0.05).Conclusion: Stapes surgery significantly improves hearing outcomes across all ages, especially in AC thresholds and ABG closure. Age should not be a contraindication if audiological criteria are met.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of vestibular rehabilitation in patients with residual dizziness after treatment for benign paroxysmal positional vertigo. 良性阵发性位置性眩晕治疗后残留头晕患者前庭康复的效果。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-27 DOI: 10.1080/00016489.2025.2506671

Tomoyuki Shiozaki, Masaharu Sakagami, Tadao Okayasu, Takao Imai, Tadashi Kitahara

{"title":"Effects of vestibular rehabilitation in patients with residual dizziness after treatment for benign paroxysmal positional vertigo.","authors":"Tomoyuki Shiozaki, Masaharu Sakagami, Tadao Okayasu, Takao Imai, Tadashi Kitahara","doi":"10.1080/00016489.2025.2506671","DOIUrl":"https://doi.org/10.1080/00016489.2025.2506671","url":null,"abstract":"Background: Benign paroxysmal positional vertigo (BPPV) is a prevalent cause of vertigo. Although canalith repositioning procedures are effective, some patients continue to experience residual dizziness (RD) and balance disturbances that adversely affect daily activities.Aims/objectives: This study aimed to assess the impact of vestibular rehabilitation on patients with RD following BPPV treatment.Material and methods: Thirty participants were allocated into two groups: a rehabilitation group (Group 1) that received weekly physiotherapy and performed home exercises for six months and an aerobic exercise instruction group (Group 2) that attended bi-monthly sessions. Outcome measures included the modified Dizziness Handicap Inventory (mDHI), posturography, Functional Gait Assessment (FGA), and Self-rating Depression Scale (SDS).Results: Both groups demonstrated significant improvements in mDHI and FGA scores pre- and post-intervention. However, only Group 1 exhibited a significant improvement in centre of pressure movement with eyes closed (COP EC) after the intervention. When comparing the two groups, post-intervention mDHI and COP EC scores showed significantly greater improvement in Group 1.Conclusions and significance: These findings suggest that vestibular rehabilitation may enhance dizziness resolution and postural control in patients with RD.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review and meta-analysis of intratympanic gentamicin for patients with Ménières disease. 一项系统回顾和荟萃分析：鼓室内庆大霉素治疗mims疾病。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-27 DOI: 10.1080/00016489.2025.2504033

Louise Devantier, Henriette Edemann Callesen, Dan Dupont Hougaard, Bjarki Ditlev Djurhuus, Frank Liviu-Adelin Guldfred, Jesper Hvass Schmidt

{"title":"A systematic review and meta-analysis of intratympanic gentamicin for patients with Ménières disease.","authors":"Louise Devantier, Henriette Edemann Callesen, Dan Dupont Hougaard, Bjarki Ditlev Djurhuus, Frank Liviu-Adelin Guldfred, Jesper Hvass Schmidt","doi":"10.1080/00016489.2025.2504033","DOIUrl":"https://doi.org/10.1080/00016489.2025.2504033","url":null,"abstract":"Background: Ménière's disease is a chronic inner ear disorder characterized by recurrent vertigo, tinnitus, aural fullness, and fluctuating sensorineural hearing loss. For patients with debilitating symptoms unresponsive to conservative treatment, intratympanic gentamicin is a therapeutic option. However, its efficacy and safety remain uncertain.Aims/objectives: This systematic review aims to evaluate the effectiveness and safety of intratympanic gentamicin in Ménière's disease, focusing exclusively on randomized controlled trials (RCTs).Material and methods: A comprehensive literature search was conducted to identify RCTs comparing intratympanic gentamicin with placebo or no treatment. Primary outcomes included vertigo frequency and severity, quality of life, and incidence of serious adverse events. Data were analyzed using the GRADE approach to assess risk of bias and certainty of evidence.Results: Three RCTs were included, demonstrating a significant reduction in vertigo frequency and severity in patients treated with intratympanic gentamicin compared to placebo. However, the evidence quality was rated very low due to small sample sizes and methodological limitations.Conclusions and significance: Findings suggest that intratympanic gentamicin may reduce vertigo in Ménière's disease. However, due to the limited certainty of the evidence, further research with larger sample sizes and standardized outcome measures is necessary to clarify its benefits and risks.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving olfactory function and sinonasal manifestations in patients with granulomatosis with polyangiitis (GPA) - a prospective intervention study. 改善肉芽肿合并多血管炎（GPA）患者的嗅觉功能和鼻窦表现——一项前瞻性干预研究。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-20 DOI: 10.1080/00016489.2025.2502564

Oliver Skjoedt Joergensen, Vitus Bugge Roennstad, Bo Baslund, Magne Bech, Ditte Gertz Mogensen, Kasper Aanaes

{"title":"Improving olfactory function and sinonasal manifestations in patients with granulomatosis with polyangiitis (GPA) - a prospective intervention study.","authors":"Oliver Skjoedt Joergensen, Vitus Bugge Roennstad, Bo Baslund, Magne Bech, Ditte Gertz Mogensen, Kasper Aanaes","doi":"10.1080/00016489.2025.2502564","DOIUrl":"https://doi.org/10.1080/00016489.2025.2502564","url":null,"abstract":"Background: No guidelines exist and very few papers are written suggesting how to treat chronic rhinosinusitis (CRS) in granulomatosis with polyangiitis (GPA) patients.Aims and objectives: We conducted this prospective non-randomized intervention study to define the disease burden in GPA and to optimize the CRS treatment attempting to alleviate the symptoms with a special focus on whether the olfactory function could be improved.Materials and methods: We included 30 participants with GPA, who underwent olfactory training therapy combined with nasal corticosteroids twice a day for six months. At the first and second out-patient visits, the following data were collected: patients' CRS symptom were scored using a Visual Analog Scale (VAS), Sinonasal Outcome Test 22 (SNOT-22), Kennedy-Lund endoscopic score, and an olfactory threshold, discrimination, and identification (TDI) test.Results: The patients with few crusts and high compliance improved their olfactory function significantly. The total cohort improved their SNOT-22 score and the facial pain subdomain significantly. No significant improvements were made regarding the VAS score.Conclusions and significance: This study identified that GPA patients' CRS symptoms can be alleviated, using nasal corticosteroids and smell training therapy. Nevertheless, patients with GPA still have a high CRS-disease burden, mostly suffering from nasal crusting.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation and psychometric properties of the quality of life in people with hearing loss questionnaire (HL-QoL) in English. 英语听力损失患者生活质量问卷（HL-QoL）的有效性和心理测量特征。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-20 DOI: 10.1080/00016489.2025.2504636

Jenna Felder, Karin A Koinig, Ilona Anderson, Angelika Illg, Mareike Billinger-Finke

{"title":"Validation and psychometric properties of the quality of life in people with hearing loss questionnaire (HL-QoL) in English.","authors":"Jenna Felder, Karin A Koinig, Ilona Anderson, Angelika Illg, Mareike Billinger-Finke","doi":"10.1080/00016489.2025.2504636","DOIUrl":"https://doi.org/10.1080/00016489.2025.2504636","url":null,"abstract":"Background: The Quality of Life in People with Hearing Loss Questionnaire (HL-QoL) measures quality of life (QoL) in individuals with hearing loss. The German version of the HL-QoL was validated in cochlear implant (CI) users.Objectives: Validation of the English version of the HL-QoL.Material and methods: The HL-QoL was forward-backward translated. 97 participants were included in the HL-QoL validation. Item and scale analyses assessed the quality of individual items and of the questionnaire in its entirety.Results: Questionnaire validation results confirmed item difficulty and item discrimination, good test reliability and construct and discriminant validity. The mean total HL-QoL score was 103 points, which indicates a 'high' quality of life. 94% of participants reported at least a 'moderate' quality of life benefit. Participants tended to have a higher QoL when their hearing loss was fully addressed, i.e. biltaral CI users with bilateral hearing loss. QoL did not correlate with age, duration of CI use, sex, or gender.Conclusion: The English version of the HL-QoL is a valid tool to assess how hearing loss and its treatment can impact an individual's quality of life. The mean total HL-QoL score suggests an overall high QoL benefit in this sample of CI users.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-catenin expression as a strong predictor of recurrence in juvenile angiofibroma. β-catenin表达是幼年血管纤维瘤复发的一个强有力的预测因子。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-20 DOI: 10.1080/00016489.2025.2504635

Marlinda Adham, Regina Talitha Rosa, Alok Thakar, Lisnawati Rachmadi, Indrati Suroyo, Joedo Prihartono

{"title":"β-catenin expression as a strong predictor of recurrence in juvenile angiofibroma.","authors":"Marlinda Adham, Regina Talitha Rosa, Alok Thakar, Lisnawati Rachmadi, Indrati Suroyo, Joedo Prihartono","doi":"10.1080/00016489.2025.2504635","DOIUrl":"https://doi.org/10.1080/00016489.2025.2504635","url":null,"abstract":"Background: Juvenile angiofibroma (JA) is a rare fibrovascular tumor affecting young males. Although histologically benign, JA is clinically aggressive, with high morbidity, mortality, and recurrence rates. While β-catenin expression is known to contribute to JA growth, its role in recurrence remains uncertain.Objective: This study investigates the relationship between β-catenin expression and recurrence risk in JA patients.Method: An analytical observational case-control study was conducted at Dr. Cipto Mangunkusumo Hospital, analyzing 33 JA patients who underwent tumor excision (2013-2022). Patients without recurrence were controls, while those with recurrence were cases. Immunohistochemistry and H-scoring quantified β-catenin expression, and statistical analysis examined its association with recurrence. ROC curves determined cut-off values.Results: Among 33 patients (all male, aged 9-28 years; mean: 16.2 years), 15 had recurrences. High β-catenin expression was significantly associated with recurrence (p = 0.000), with an H-score cut-off of 124.2 (100% sensitivity/specificity). Age ≤18 years correlated with higher recurrence risk (p < .05; OR 8.9). Tumor size, volume, stage, pre-extirpation procedures, surgical techniques, and intraoperative blood loss had no significant effect.Conclusion: High β-catenin expression is a strong predictor of JA recurrence, suggesting its potential as a prognostic marker. Targeting β-catenin pathways may aid in recurrence prevention and improved JA management.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional and adaptive speech audiometry in single-sided deaf (SSD) subjects rehabilitated by bone conductive implants (BCI), quality of life and long-term utilization. 单侧耳聋经骨传导植入（BCI）康复者的传统和自适应语音测听、生活质量和长期使用。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-17 DOI: 10.1080/00016489.2025.2504032

Edoardo Covelli, Chiara Filippi, Francesco Lazzerini, Elisabetta Tromboni, Silvia Tarentini, Sofia Pizzolante, Francesca Forli, Stefano Berrettini, Luca Bruschini

{"title":"Traditional and adaptive speech audiometry in single-sided deaf (SSD) subjects rehabilitated by bone conductive implants (BCI), quality of life and long-term utilization.","authors":"Edoardo Covelli, Chiara Filippi, Francesco Lazzerini, Elisabetta Tromboni, Silvia Tarentini, Sofia Pizzolante, Francesca Forli, Stefano Berrettini, Luca Bruschini","doi":"10.1080/00016489.2025.2504032","DOIUrl":"https://doi.org/10.1080/00016489.2025.2504032","url":null,"abstract":"Background: Single-sided deafness (SSD) encompasses the presence of a profoundly deaf ear with a normal, contralateral one. Patients with SSD may have difficulty with speech intelligibility in noise and localizing sounds.Aims/objectives: This retrospective study aims to evaluate the long-term effectiveness of bone conduction implant (BCI) in a group of patients with SSD.Material and methods: Audiologic benefit was assessed through conventional speech audiometry and adaptive Matrix test. Impact on quality of life was evaluated with the Glasgow Benefit Inventory (GBI) questionnaire. BCI usage data were also obtained from each subject.Results: Thirty-two patients were included. No statistically significant improvements were found at standard audiometric tests using BCI, but at Matrix test the mean SRT is reached at S/N -1.16 dB without BCI and -2.07 with BCI with a statistically significant difference (p = 0.026). The mean GBI score was 25.12, ranging from -8.3 to 47.2. Ten subjects (31%) discontinued the BCI use overtime.Conclusions and significance: Benefit assessment of BCI in SSD recipients can be difficult. Adaptive audiometric test could be useful. Quality of life measures seem to suggest potential 'beyond-auditory' benefits. SSD recipients can be inconsistent users of BCI.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0