Acta Oto-Laryngologica最新文献

Differential diagnosis between pleomorphic adenoma and carcinoma ex pleomorphic adenoma: focus on clinical and MR findings.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-09 DOI: 10.1080/00016489.2025.2480687

Asuka Sato, Tomoyasu Tachibana, Yuichiro Kanie, Minami Kakiuchi, Akifumi Kariya, Chieko Furukawa, Yuto Naoi, Yasuharu Sato, Mizuo Ando

{"title":"Differential diagnosis between pleomorphic adenoma and carcinoma ex pleomorphic adenoma: focus on clinical and MR findings.","authors":"Asuka Sato, Tomoyasu Tachibana, Yuichiro Kanie, Minami Kakiuchi, Akifumi Kariya, Chieko Furukawa, Yuto Naoi, Yasuharu Sato, Mizuo Ando","doi":"10.1080/00016489.2025.2480687","DOIUrl":"https://doi.org/10.1080/00016489.2025.2480687","url":null,"abstract":"Background: In parotid tumors, preoperative differential diagnosis between pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA) remains challenging.Objectives: The present study aimed to evaluate the clinical characteristics of CXPA and PA and to identify factors associated with the differential diagnosis of these conditions.Material and methods: We reviewed the medical records of 6 CXPA and 127 PA patients treated surgically at our institution between 2008 and 2024.Result: Univariate analysis revealed significant differences in spontaneous pain (p = .044), facial nerve palsy (p = .045), and subjective enlargement (p < .01) between the CXPA and PA patients. Magnetic resonance imaging (MRI) revealed that the proportions of masses with ill-defined margins, localization in the deep lobe, and low apparent diffusion coefficient (ADC) were significantly higher in patients with CXPA than in those with PA (p < .01, p = .048, and p < .01, respectively). Multivariate analysis identified that spontaneous pain and masses with ill-defined margins were associated with CXPA (p = .047 and p = .013, respectively).Conclusion: Spontaneous pain and masses with ill-defined margins could be suggestive of CXPA rather than PA. Low ADC levels indicate the possibility of CXPA.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory neurophysiological characteristics in unilateral deafness: influence of deafness side.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-09 DOI: 10.1080/00016489.2025.2487641

Seval Ceylan, Şule Çekiç

{"title":"Auditory neurophysiological characteristics in unilateral deafness: influence of deafness side.","authors":"Seval Ceylan, Şule Çekiç","doi":"10.1080/00016489.2025.2487641","DOIUrl":"https://doi.org/10.1080/00016489.2025.2487641","url":null,"abstract":"Background: The characteristics of auditory processing and reorganization after unilateral deafness remain unclear.Aims/objectives: This study aimed to examine subcortical and cortical auditory neurophysiological features in young adults with unilateral deafness according to the side of deafness.Methods: Patient group: A total of 27 men (25.93- ± 3.64-year old) with unilateral deafness [15 right-sided and 12 left-sided deafness (L-SD)] were included. Twenty-one adult males (29.90 ± 3.05 years) with normal bilateral hearing were included in the Normal Control group. Neurodiagnostic Auditory Brainstem Responses (ABR) and Cortical Auditory Evoked Potentials (CAEP) tests were performed on all participants. ABR and CAEP results were compared between groups.Results: In the right-sided deafness (R-SD) group, ABR wave V amplitudes (left ear) were higher than the control group, and the III-V interpeak latencies were found to be shorter (p = .007, p = .032, respectively). In the L-SD group: CAEP wave P1N1 and N1P2 amplitudes were higher than in the R-SD group (p = .037, p = .015, respectively).Conclusions and significance: Auditory neurophysiological biomarkers in adults with unilateral deafness differ according to the side of the deafness. The results of this study may provide preliminary information for the development of appropriate rehabilitation methods according to the deafness side after single-sided deafness.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding cholesteatoma radiological dimensions: unveiling the discrepancy between CT and MRI imaging and development of a predictive model based on CT and MRI volume comparison.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-08 DOI: 10.1080/00016489.2025.2484560

Edoardo Covelli, Alessandro Bozzao, Piero Giuseppe Meliante, Chiara Filippi, Sofia Pizzolante, Haitham H Elfarargy, Andrea Romano, Maurizio Barbara

{"title":"Decoding cholesteatoma radiological dimensions: unveiling the discrepancy between CT and MRI imaging and development of a predictive model based on CT and MRI volume comparison.","authors":"Edoardo Covelli, Alessandro Bozzao, Piero Giuseppe Meliante, Chiara Filippi, Sofia Pizzolante, Haitham H Elfarargy, Andrea Romano, Maurizio Barbara","doi":"10.1080/00016489.2025.2484560","DOIUrl":"https://doi.org/10.1080/00016489.2025.2484560","url":null,"abstract":"Background: Cholesteatoma (CHO) presents a significant threat to middle ear integrity, potentially leading to severe complications. Radiological assessment is crucial for understanding CHO anatomy, with high-resolution CT scans commonly used despite limitations in sensitivity and size overestimation. Recent advancements in non-echo planar imaging (EPI) diffusion-weighted imaging (DWI) MRI offer improved sensitivity, but accessibility issues persist.Objectives: The objective of this study is to compare CHO volume, as measured by CT scans, and the gold standard non-EPI DWI MRI.Materials and methods: A prospective clinical trial involving 39 participants with middle-ear CHO compared CT and non-EPI DWI MRI volumes. Patients underwent both imaging modalities, and volumes were measured using a co-registration technique.Results: Median CHO volumes measured by MRI and CT showed a notable difference. The Bland-Altman plot indicated one outlier, removed for further analysis. Linear regression suggested a correlation, with CT volumes overestimating MRI volumes by a factor of four.Conclusions: Our study establishes a formula to estimate CHO size, highlighting the tendency of CT scans to overestimate volumes. While non-EPI DWI MRI remains the gold standard for accurate measurements, our findings emphasize the complementary roles of CT and MRI in CHO diagnosis and post-surgical follow-up through fusion techniques.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revision of the Turkish Khalfa Hyperacusis Questionnaire: a boosted tool for the tinnitus population.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-08 DOI: 10.1080/00016489.2025.2485438

Nazife Öztürk Özdeş, Gizem Kır, Suna Tokgöz-Yılmaz

{"title":"Revision of the Turkish Khalfa Hyperacusis Questionnaire: a boosted tool for the tinnitus population.","authors":"Nazife Öztürk Özdeş, Gizem Kır, Suna Tokgöz-Yılmaz","doi":"10.1080/00016489.2025.2485438","DOIUrl":"https://doi.org/10.1080/00016489.2025.2485438","url":null,"abstract":"Background: Due to low factor loadings and problems with construct validity of the current version of the Turkish Khalfa Hyperacusis Questionnaire, there is a need for a revision that can more accurately assess hyperacusis in individuals with tinnitus.Objective: The main aim of this study was to re-evaluate the Khalfa Hyperacusis Questionnaire for individuals with tinnitus and to analyze its reliability and validity.Materials and methods: The new version of Khalfa Hyperacusis Questionnaire (HQ-R), consisting of 12 items, was tested on 269 participants with tinnitus and the suitability of the two-factor structure was evaluated by Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA).Results: EFA revealed that the scale explained 60.247% of the total variability and the factor loadings were strong. It was determined that the CFA model provided an excellent fit. The CA value of the instrument was found to be 0.908 and a high level of reliability was obtained. The cut-off score was 14 and this value was used to accurately classify hyperacusis.Conclusion: The HQ-R provides a measurement tool that can more precisely and accurately assess hyperacusis in individuals with tinnitus. The improvements will be an important resource for clinicians and researchers working with tinnitus patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-stage bone-anchored hearing implant surgery in children: a prospective comparative study.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-08 DOI: 10.1080/00016489.2025.2476188

Emma M Teunissen, Tjerk W Aukema, Coosje J I Caspers, Kim H E Bakkum, Ivo J Kruyt, Froukje L J Cals, Emmanuel A M Mylanus, Myrthe K S Hol

引用次数: 0

C1QL1 regulates auditory nerve fibers growth via ELMO1-DOCK180-RAC1 integrin.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-07 DOI: 10.1080/00016489.2025.2486613

Minglin Chen, Yue Qi, Shusheng Gong

{"title":"C1QL1 regulates auditory nerve fibers growth via ELMO1-DOCK180-RAC1 integrin.","authors":"Minglin Chen, Yue Qi, Shusheng Gong","doi":"10.1080/00016489.2025.2486613","DOIUrl":"https://doi.org/10.1080/00016489.2025.2486613","url":null,"abstract":"Background: Complement C1q Like 1 (C1QL1), a secreted protein, is known to play an important role in synaptic maturation, regulation, and maintenance in central nervous system. C1QL1 is expressed in adult cochlea inner and outer hair cells. However, the mechanism of C1QL1 in cochlea remains unclear.Objective: This study aims to reveal the mechanism of C1ql1 gene in cochlea, including its target and pathway.Material and methods: The protein-protein interaction analysis of C1QL1 was conducted with STRING database. The interaction between C1QL1 and BAI3 in cochlea was further confirmed by colocalization and co-immunoprecipitation. via upregulating and downregulating the expression of C1ql1, the factors in the pathway can be detected.Results: C1QL1 protein interacts with BAI3 protein in cochlea. C1ql1 overexpression had no effect on auditory phenotype. C1ql1 regulates auditory nerve fibers growth via BAI3 and ELMO1-DOCK180-RAC1 integrin. Meanwhile, C1ql1 overexpression inhibited the expression of TIAM1-PARD3 integrin.Conclusions and significance: C1QL1 interacts with BAI3 in cochlea and C1ql1 regulates auditory nerve fibers growth via ELMO1-DOCK180-RAC1 integrin. C1ql1 overexpression can inhibit the expression of TIAM1-PARD3 integrin.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlating audiological results with location of intracochlear schwannoma assessed by routine and Hydrops MRI.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-07 DOI: 10.1080/00016489.2025.2484790

Yen-Ting Guo, Yu-Fen Wang, Yi-Ho Young

{"title":"Correlating audiological results with location of intracochlear schwannoma assessed by routine and Hydrops MRI.","authors":"Yen-Ting Guo, Yu-Fen Wang, Yi-Ho Young","doi":"10.1080/00016489.2025.2484790","DOIUrl":"https://doi.org/10.1080/00016489.2025.2484790","url":null,"abstract":"Background: Whether an intracochlear schwannoma (ICS) concomitant with endolymphatic hydrops (EH) remains unclear.Objective: This study had two objectives: first, to correlate the location of ICS with audiological results using routine MRI; and second, to determine whether an ICS is associated with EH using Hydrops MRI.Methods: Four cases with ICS demonstrated by routine MRI underwent an inner ear test battery, followed by 3 T Hydrops MRI.Results: Audiometry revealed total deafness in 2 patients, flat-type hearing loss in one and 2 kHz dip type hearing loss in 1. Routine MRI demonstrated an ICS at cochlear basal turn in 3, and cochlear middle turn in 2 (one case showed ICS at the basal and middle turns). Correlating audiological results with the location of ICS suggests that hearing deterioration may be associated with affected cochlear turn. Hydrops MRI identified Grade II cochlear EH in two ICS patients with vertigo, but not in another two ICS patients without vertigo.Conclusion: For an ICS patient with vertiginous episode, routine MRI along with Hydrops MRI may help identify both the ICS and EH, simultaneously.Significance: A 'wait and scan' approach, which includes routine MRI along with Hydrops MRI, is recommended for the follow-up of ICS patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic, survival, and tumor control outcomes of parapharyngeal space liposarcoma: a systematic review.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1080/00016489.2025.2462688

Srivatsa Surya Vasudevan, Estephania Candelo, Tiba Yamin Kandrikar, Jeffrey R Janus

{"title":"Diagnostic, survival, and tumor control outcomes of parapharyngeal space liposarcoma: a systematic review.","authors":"Srivatsa Surya Vasudevan, Estephania Candelo, Tiba Yamin Kandrikar, Jeffrey R Janus","doi":"10.1080/00016489.2025.2462688","DOIUrl":"10.1080/00016489.2025.2462688","url":null,"abstract":"Background: Parapharyngeal space liposarcomas (PPS-LS) are rare tumors often associated with a moderate-to-poor prognosis.Objectives: This study aims to assess tumor control and survival outcomes across the various subtypes of PPS-LS.Material and methods: We conducted a systematic review of cases using PubMed, OVID, Scopus, Web of Science, ScienceDirect, and EBSCO from inception to October 2024. Given the data on individual patient follow-up, Kaplan-Meier survival analysis was utilized to calculate disease-free survival (DFS) and disease-specific survival (DSS).Results: Out of 303 articles, 10 studies with 11 patients (72.7% male) met the inclusion criteria, with a mean age of 51.3 years (range: 12-77.5). Preoperative fine needle aspiration cytology was conducted in 45.4%, with 80% yielding inconclusive results. The 2-year and 5-year DFS rates for PPS-LS were 64% and 50%, respectively, while the 2-year DSS rate was 84%. Tumor recurrence occurred in 36.3% of patients, with an average of 2.5 recurrences per patient, specifically the myxoid subtype of PPS-LS.Conclusion: This systematic review highlights the varied prognostic outcomes of PPS-LS and its subtypes, emphasizing the need for vigilant surveillance to improve DFS and reduce recurrence rates.Significance: This provides surgeons with critical insights into probable prognostic outcomes when dealing with specific subtypes of PPS-LS.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"348-354"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gap-induced inhibition of the post-auricular muscle response in miniature pigs.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1080/00016489.2025.2464698

Hanwen Zhou, Peng Liu, Chi Zhang, Xinmiao Xue, Xuemin Chen, Zhixin Zhang, Weidong Shen, Shiming Yang, Mengyun Fan, Fangyuan Wang

{"title":"Gap-induced inhibition of the post-auricular muscle response in miniature pigs.","authors":"Hanwen Zhou, Peng Liu, Chi Zhang, Xinmiao Xue, Xuemin Chen, Zhixin Zhang, Weidong Shen, Shiming Yang, Mengyun Fan, Fangyuan Wang","doi":"10.1080/00016489.2025.2464698","DOIUrl":"10.1080/00016489.2025.2464698","url":null,"abstract":"Background: Tinnitus, a persistent condition that significantly impairs the quality of life for patients, poses a substantial burden on society. Owing to its complex and poorly understood pathogenesis, the development of effective animal models for tinnitus is imperative to enhance our comprehension of this condition.Objectives: The present study aims to establish a large animal model to delineate the mechanisms underlying the onset of tinnitus.Materials and methods: For the first time, we conducted a comparative analysis of the Post-Auricular Muscle Response (PAMR) and the Eye Blink Response (EBR) in miniature pigs, demonstrating their utility in manifesting Gap Prepulse Inhibition of the Acoustic Startle (GPIAS). Subsequently, we employed the gap-induced inhibition of PAMR to ascertain evidence of tinnitus following noise exposure.Results and conclusion: Through comparing the efficacy of PAMR and EBR in GPIAS detection, we have substantiated that PAMR provides a stable and objective reflection of GPIAS. Consequently, PAMR emerges as a reliable method for measuring GPIAS in miniature pigs. Furthermore, the behavioral paradigm of gap-induced inhibition of PAMR successfully identified behavioral evidence of tinnitus subsequent to noise exposure.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"291-298"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of nasal microplastic densities in patients with acute and chronic rhinitis.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1080/00016489.2025.2468396

Ayşegül Tuna, Yeşim İtmeç, Birgül Kaçmaz, Serdar Gül, Sedat Kaygusuz

{"title":"Evaluation of nasal microplastic densities in patients with acute and chronic rhinitis.","authors":"Ayşegül Tuna, Yeşim İtmeç, Birgül Kaçmaz, Serdar Gül, Sedat Kaygusuz","doi":"10.1080/00016489.2025.2468396","DOIUrl":"10.1080/00016489.2025.2468396","url":null,"abstract":"Background: Increasing plastic consumption has made microplastics a persistent environmental pollutant present in the atmosphere and other ecosystems. These particles can enter biological tissues via ingestion, skin contact, or inhalation and potentially cause rhinitis and other respiratory diseases through inflammatory and cytotoxic effects.Objectives: This study evaluated the association between nasal inhalation of microplastics, a contributor to air pollution, and rhinitis symptoms, as well as their role in the etiology of acute and chronic rhinitis.Materials and methods: Sixty patients were equally divided into two groups: acute rhinitis (30 patients) and chronic rhinitis (30 patients). Demographic data, including age and gender, and total nasal symptom scores were recorded. Nasal lavage samples were collected and the number of microplastics in these samples was analyzed. Groups were compared based on microplastic counts.Results: The acute rhinitis group had significantly higher microplastic levels than the chronic rhinitis group. Microplastics were detected in at least one sample from each participant, regardless of gender, age, or symptom score.Conclusions and significance: The higher concentration of microplastics in acute rhinitis highlights their potential role in exacerbations and underscores the need for preventive strategies and further research on their long-term health effects.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"308-312"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0