Acta Oto-Laryngologica最新文献

{"title":"Seasonality and climatic associations with deep neck space abscesses in Korea: a canonical correlation analysis.","authors":"Su Il Kim, Hun Hee Lee, Su Jin Kim, Young-Gyu Eun, Young Chan Lee","doi":"10.1080/00016489.2025.2501602","DOIUrl":"https://doi.org/10.1080/00016489.2025.2501602","url":null,"abstract":"<p><strong>Background: </strong>Deep neck space abscesses are a significant medical issue, but their seasonality and climatic associations remain unclear.</p><p><strong>Objectives: </strong>This study aimed to examine the seasonality of deep neck space abscesses and identify associated climatic factors using a nationwide, population-based dataset.</p><p><strong>Material and methods: </strong>We utilized Korean National Health Insurance data (2010-2019) to identify patients with peritonsillar, retropharyngeal, and parapharyngeal abscesses (J36, J39.0, J39.1). Seasonality was assessed by calculating the ratio of the highest to lowest monthly incidence. Multivariate canonical correlation analysis (CCA) evaluated associations with climatic factors, including temperature, humidity, precipitation, sunlight, ground temperature, particulate matter (<10 µm), ultraviolet A dose, and daily temperature range.</p><p><strong>Results: </strong>The incidence of deep neck space abscesses peaked in winter and was lowest in summer, with seasonality ratios of 2.03 (peritonsillar) and 2.15 (retropharyngeal and parapharyngeal). CCA demonstrated a strong correlation between climatic factors and abscess incidence. The two canonical roots had high canonical coefficients R of 0.7996 and 0.5542, respectively (<i>p</i> < 0.0001 and <0.0001).</p><p><strong>Conclusion and significance: </strong>This large population-based study highlights the seasonality and climatic relevance of deep neck space abscesses. Further research is needed to explore demographic factors affecting incidence.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT-4 vs. multi-disciplinary tumor board decisions for the therapeutic management of primary laryngeal cancer.","authors":"Erim Pamuk, Yaşar Enez Bilen, Çağrı Külekçi, Oğuz Kuşcu","doi":"10.1080/00016489.2025.2502563","DOIUrl":"https://doi.org/10.1080/00016489.2025.2502563","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence-based clinical decision support systems are promising tools for addressing the increasing complexity of oncological data and treatment. However, the integration and validation of models such as ChatGPT within multidisciplinary decision-making processes for head and neck cancers remain limited.</p><p><strong>Objective: </strong>To evaluate the performance of ChatGPT-4 in the management of primary laryngeal cancer and compare it with multidisciplinary tumor board (MDT) decisions.</p><p><strong>Methods: </strong>The medical records of 25 patients with untreated laryngeal cancer were evaluated using ChatGPT-4 for therapeutic recommendations. The coherence of responses was graded from Grade 1 (totally coherent) to Grade 4 (totally incoherent) and compared with actual MDT decisions. The association between patient features and response grades was also assessed.</p><p><strong>Results: </strong>ChatGPT-4 provided totally coherent (Grade 1) responses consistent with MDT decisions in 72% of the patients. The rates of Grade 2 and Grade 3 coherent responses were 20% and 8%, respectively. There were no totally incoherent responses. There was no significant association between the grade of coherence and T stage, N stage, tumor localization, differentiation, or age (<i>p</i> = 0.106, <i>p</i> = 0.588, <i>p</i> = 0.271, <i>p</i> = 0.677, <i>p</i> = 0.506, respectively).</p><p><strong>Conclusion: </strong>With further improvements, ChatGPT-4 can be a promising adjunct tool for clinicians in decision-making for primary laryngeal cancer.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A descriptive study on laryngotracheal stenosis in the Northern Sweden.","authors":"Anders Erlandsson, Martin Lundahl, Anna Holm, Katarina Olofsson","doi":"10.1080/00016489.2025.2503000","DOIUrl":"https://doi.org/10.1080/00016489.2025.2503000","url":null,"abstract":"<p><strong>Background: </strong>We have in a retrospective design used laryngotracheal stenosis (LTS) classification to describe stenotic subsites and through international classification of disease (ICD-10) codes its diagnostic origins. The diagnostic challenge posed by varied etiologies can lead to treatment delays, in potentially life-threatening conditions.</p><p><strong>Aims/objectives: </strong>The purpose of this study is to explore and ascertain the etiological and anatomical distribution of LTS to reduce misdiagnosis and as such delayed access to adequate treatment.</p><p><strong>Material and methods: </strong>The included cases were consecutively recruited between 1999 and 2019, all labeled with relevant ICD-10 codes for the research question in combination with medical records for evaluation of its accuracy. The primary outcome was the causes, and anatomical locations of LTS.</p><p><strong>Results: </strong>A total of 1441 records were screened, with 1071 cases meeting the inclusion criteria. The most common cause was unilateral vocal fold immobility, followed by glottic cancer. Benign causes were more prevalent than malignant ones, with glottic-level stenoses being most frequent.</p><p><strong>Conclusion and significance: </strong>Unilateral vocal fold immobility is the most prevalent cause of LTS in our material. These findings can enhance diagnostic efficiency by increasing clinical awareness of common etiologies.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Side selection of cochlear implant in patients after head trauma: a new perspective.","authors":"Xinyue Zou, Jingyuan Chen, Biao Chen, Ying Shi, Chunling Ma, Simeng Lu, Yujing Cheng, Ying Kong, Yongxin Li","doi":"10.1080/00016489.2025.2501598","DOIUrl":"https://doi.org/10.1080/00016489.2025.2501598","url":null,"abstract":"<p><strong>Background: </strong>Head trauma often leads to bilateral sensorineural hearing loss (SNHL), and determining the optimal side for cochlear implantation (CI) remains a critical issue that requires further investigation. Objective: To evaluate the role of preoperative aided threshold (AT) testing in selecting the optimal CI side for patients with bilateral SNHL caused by head trauma.</p><p><strong>Methods: </strong>This study included 9 patients with bilateral SNHL resulting from head trauma. Preoperative audiological and radiological evaluations were performed. The correlation between preoperative AT, duration of deafness (DoD), radiological findings, and Nijmegen Cochlear Implant Questionnaire (NCIQ) scores was analyzed.</p><p><strong>Results: </strong>Preoperative AT showed a tendency for a negative correlation with advanced sound perception scores (r = -0.740, <i>p</i> = 0.057), while DoD exhibited a significant negative correlation with auditory self-confidence (r = -0.803, <i>p</i> = 0.029). Imaging combined with AT provides a foundational framework for selecting the implantation side; however, the limited sample size restricts the generalizability of the findings.</p><p><strong>Conclusion: </strong>Lower preoperative AT and shorter DoD may predict better auditory rehabilitation outcomes following CI. It is recommended to integrate imaging and audiological evaluations for individualized decision-making. Future studies with larger sample sizes are necessary to validate these findings and explore the clinical implications of early CI.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation method of dynamic range parameters for cochlear implants based on neural response telemetry threshold.","authors":"Yao Liu, Yue Wang, Yu Chen, Wei Wang","doi":"10.1080/00016489.2025.2492359","DOIUrl":"https://doi.org/10.1080/00016489.2025.2492359","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of correlation studies between subjective behavioral test threshold and neural response telemetry (NRT) thresholds in cochlear implant (CI) patients. At present, there is no predictive model that can predict the parameters of CI adjustment objectively and reliably.</p><p><strong>Objectives: </strong>To explore the correlation between the subjective behavior test method threshold and the NRT thresholds in patients with CI with normal cochlear (NC) morphology and inner ear malformation (IEM). To explore the value of using deep learning technology to predict the parameters of machine adjustment and guide the postoperative machine adjustment.</p><p><strong>Methods: </strong>NRT and subjective behavior tests were conducted on 57 cases of CI patients with NC morphology and 20 cases of IEM using electrodes 1, 6, 11, 16, and 22, respectively. The correlation between the NRT thresholds and T and C values was analyzed. Using deep learning techniques, establish a prediction model based on convolutional neural networks to predict the parameters of machine adjustment of CI.</p><p><strong>Results: </strong>The average NRT thresholds values of the NC group and the IEM group were both greater than the T values, close to and slightly smaller than the C values. The average values of T values, C values, and NRT thresholds in the IEM group were slightly higher than those in the NC group. The NRT thresholds of the both groups is significantly correlated with the C values and T values. The constructed prediction model has high accuracy between the predicted values and the actual values of each electrode. Moreover, the linear regression equation between the predicted and actual values is highly similar.</p><p><strong>Conclusions: </strong>The NRT thresholds is significantly related to the subjective behavior test threshold. The correlation between NRT thresholds and T or C values can be used to assist in CI tuning. Especially for patients with IEM, different machine adjustment strategies should be adopted compared to NC patients. Moreover, the constructed neural network prediction model can also guide the postoperative adjustment of patients with cochlear implants.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a collaborative framework for assessment of peripheral facial paralysis using facial image regions of interest.","authors":"Xiaoyan Guo, Jiyue Chen, Pingju Lin, Qi Lu, Ting Kou, Kun Li, Shiming Yang, Weidong Shen","doi":"10.1080/00016489.2025.2502562","DOIUrl":"https://doi.org/10.1080/00016489.2025.2502562","url":null,"abstract":"<p><strong>Background: </strong>While accurate evaluation of PFP is crucial for determining optimal treatment strategies, current clinical assessments rely heavily on subjective evaluations, leading to considerable variability between inter- and intra-observer ratings.</p><p><strong>Objective: </strong>This study aimed to develop and validate a collaborative framework for evaluating PFP based on regions of interest in facial images.</p><p><strong>Methods: </strong>We developed and tested two approaches: (1) a collaborative framework integrating image interpretation techniques (representation learning <i>via</i> CNN) with predefined handcrafted features based on regions of interest in facial images, and (2) a convolutional neural network (CNN) model trained exclusively on full-face patient images. The diagnostic accuracy of both systems was evaluated using a test set and compared with otologists' assessments.</p><p><strong>Results: </strong>The collaborative framework achieved a mean Area Under the Curve (AUC) of 0.92 for PFP prediction in the test set, surpassing the 0.76 AUC achieved by the CNN trained on full-face images. The framework's performance matched that of experienced otologists (accuracy: 80.0% vs. 77.2%; sensitivity: 85.3% vs. 77.7%). Moreover, system assistance improved primary clinicians' mean accuracy by 17.7 percentage points.</p><p><strong>Conclusions: </strong>These findings demonstrate that our collaborative framework-based automated diagnosis system can effectively assist clinicians in PFP diagnosis.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-11"},"PeriodicalIF":1.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of endoscopic full-thickness cartilage-perichondrium complex tympanoplasty in the treatment of adhesive otitis media: a retrospective study.","authors":"Miao Xie, Siyu Li, Rui Yang, Yuchen Zhou, Xia Gao, Maoli Duan, Ling Lu","doi":"10.1080/00016489.2025.2501604","DOIUrl":"https://doi.org/10.1080/00016489.2025.2501604","url":null,"abstract":"<p><strong>Background: </strong>Adhesive otitis media (AdOM) is a common residual disease and surgical treatment for AdOM remains controversial.</p><p><strong>Objectives: </strong>The aims of present study are to investigate the feasibility and short-term effectiveness of endoscopic full-thickness cartilage-perichondrium complex tympanoplasty in the AdOM.</p><p><strong>Methods: </strong>This was a retrospective study on AdOM patients. Thirty-four patients were enrolled and followed for 1 year. Pure tone audiometry at pre and post-surgery were performed. The Chinese version of the chronic otitis media outcome test 15 (COMOT-15) was applied to assess symptoms of the patients.</p><p><strong>Results: </strong>All operated ears of the patients had dry ears at 1-year follow-up. The mean PTA decreased from 50.21 ± 11.08 to 37.06 ± 11.41 dB HL postoperatively (<i>p</i> < 0.0001), and the mean air-bone gap decreased from 24.85 ± 10.56 to 16.97 ± 7.68 dB HL postoperatively (<i>p</i> < 0.0001). Further, the average total score of COMOT-15 decreased from 30.56 ± 14.90 to 12.79 ± 12.53 postoperatively (<i>p</i> < 0.0001). The average symptomatic score of COMOT-15 decreased from 18.29 ± 9.23 to 7.38 ± 6.81 (<i>p</i> < 0.0001), and the average psychological score of COMOT-15 decreased from 12.24 ± 6.90 to 5.41 ± 6.19 respectively (<i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>Endoscopic full-thickness cartilage-perichondrium complex tympanoplasty is effective in treating AdOM. A prospective study is needed in the future.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compliance with tympanostomy tube insertion guidelines in Finland.","authors":"Vesa Lahdes, Tuomo Puhakka, Tero Vahlberg, Lotta Haavisto","doi":"10.1080/00016489.2025.2494827","DOIUrl":"https://doi.org/10.1080/00016489.2025.2494827","url":null,"abstract":"<p><strong>Backround: </strong>Tympanostomy tube insertion (TTI) is the most common pediatric surgical procedure in otorhinolaryngology.</p><p><strong>Objectives: </strong>To evaluate the appropriateness of TTI in relation to national recommendations in Finland. As a secondary aim, we assessed long term ear-related quality of life if surgical criteria are unmet.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed all TTI procedures performed on children under 10 years of age in 2019 in Turku University Hospital, Finland. Factors contributing to the operation were identified and evalued in detail. In 2021, caregivers received a questionnaire including Otitis Media 6 -questionnaire to assess ear-related quality of life.</p><p><strong>Results: </strong>A total of 355 operations were analyzed. The national criteria for recurrent acute otitis media were met in 119/355 cases (33%) and chronic otitis media with effusion criteria in 81/355 (23%), while 155/355 (44%) did not fulfil either criterion. Ear-related quality of life was high across all groups with no significant differences observed.</p><p><strong>Conclusions and significance: </strong>The substantial proportion of procedures conducted outside Finnish recommendations underlines the necessity for continuous professional education and systematic evaluation of clinical decision-making. Observed discrepancies between Finnish and international guidelines further support the re-evaluation of Finnish criteria to ensure alignment with global standards and evidence-based practice.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of environmental lighting on oculomotor tests results: a cross-sectional study.","authors":"Muhammed Pınar, Ayşenur Aykul Yağcıoğlu, Işılay Öz","doi":"10.1080/00016489.2025.2498401","DOIUrl":"https://doi.org/10.1080/00016489.2025.2498401","url":null,"abstract":"<p><strong>Background: </strong>Oculomotor tests (saccade, smooth pursuit and optokinetic test) are routinely used in clinical evaluations of the central vestibular system. There is no clear information about the lighting (light or dark) of the environment in which oculomotor tests are performed.</p><p><strong>Objectives: </strong>To determine optimum environment lighting by comparing oculomotor test results in bright and dark environments in healthy adults.</p><p><strong>Materials and methods: </strong>The study included 31 healthy adults aged between 18 and 30 without hearing or balance complaints. The participants were administered the Oculomotor tests in light and dark environments. Velocity, accuracy, and latency were compared in the saccade test, gain and asymmetry in the smooth pursuit test, and gain values in the optokinetic test.</p><p><strong>Results: </strong>The study found no statistically significant differences between light and dark environments in saccade, smooth pursuit, and optokinetic test (<i>p</i>> 0.05). However, the latency value determined, especially in the saccade test, was prolonged in the dark environment.</p><p><strong>Conclusions and significance: </strong>The minimal differences between the two environments obtained as a result of the study may lead to false negative results in patients with suspected central vestibular system pathology, making differential diagnosis difficult.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear inflammation in AAV-mediated gene therapy: serotype-dependent macrophage activation and promoter-driven immunogenicity.","authors":"Xiaochen Ni, Hongdong Liu, Xiaojun Ji, Zhifeng Chen, Xihang Chen, Yi Luo, Wei Chen, Shiming Yang","doi":"10.1080/00016489.2025.2492366","DOIUrl":"https://doi.org/10.1080/00016489.2025.2492366","url":null,"abstract":"<p><strong>Background: </strong>Recent clinical trials employing AAV (adeno-associated virus)-mediated gene therapy for hereditary deafness have demonstrated significant therapeutic potential. However, immune responses triggered by AAV delivery in the inner ear remain poorly characterized, despite their critical implications for treatment safety and efficacy.</p><p><strong>Aims/objectives: </strong>This study systematically evaluates serotype-specific (AAV1 vs. AAV9) and promoter-dependent (CMV vs CBA) immune responses in murine cochleae following local AAV delivery.</p><p><strong>Materials and methods: </strong>Recombinant AAV1/AAV9 vectors expressing tdTomato under CMV or CBA promoters were injected <i>via</i> the posterior semicircular canal. Macrophage infiltration (F4/80+/CD68+ cells) was tracked for five weeks <i>via</i> immunohistochemistry.</p><p><strong>Results: </strong>Temporal analysis revealed inflammation onset at one week, peaking at two weeks, and resolving to baseline by five weeks. CMV-driven vectors provoked significantly stronger immune activation than CBA. Serotype comparisons showed AAV9 induced greater immunogenicity, with elevated F4/80+ cells at two weeks (<i>p</i> < .001) and prolonged CD68+ cell elevation through four weeks (<i>p <</i> .001) versus AAV1. AAV9 triggered diffuse inflammation, while AAV1 responses were modiolus-restricted.</p><p><strong>Conclusions and significance: </strong>These findings highlight serotype- and promoter-dependent immunogenicity as key determinants of cochlear inflammation. Strategic selection of AAV components is essential to balance transduction efficiency and immune tolerance in inner ear gene therapy.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}