Acta Oto-Laryngologica最新文献_第2页

Speech perception and hearing preservation after cochlear implantation in patients with Meniere's disease. 梅尼埃病患者人工耳蜗植入术后的语言感知和听力保护。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-24 DOI: 10.1080/00016489.2025.2481501

Karin Hallin, Nadine Schart-Morén, Helge Rask-Andersen

{"title":"Speech perception and hearing preservation after cochlear implantation in patients with Meniere's disease.","authors":"Karin Hallin, Nadine Schart-Morén, Helge Rask-Andersen","doi":"10.1080/00016489.2025.2481501","DOIUrl":"10.1080/00016489.2025.2481501","url":null,"abstract":"Introduction: Cochlear implantation can be used as a treatment for severe sensorineural hearing loss in patients with Meniere's disease.Aim: The aim of the present study was to investigate speech perception and the grade of hearing preservation in patients diagnosed with Meniere's disease. One additional aim was to investigate the effects of cochlear implant surgery on balance and tinnitus.Methods: Adult patients with a known diagnosis of Meniere's disease were evaluated. Their speech perception and the degree of hearing preservation were compared with adult patients with sensorineural hearing loss of different etiologies. For the patients with Meniere's disease, their subjective reports on balance and tinnitus pre- and post-surgery were also investigated.Results: Both groups showed a statistically significant improvement in speech perception after cochlear implantation (p < .05); no statistically significant difference was found between the two groups. Analysis of hearing preservation for the two groups showed no statistically significant difference. Tinnitus decreased in 44.4% of the Meniere's disease patients one year post surgery.Conclusion: We found no difference in speech perception with cochlear implant in patients with Meniere's disease compared with patients with other etiologies, and there was no difference in the rate of hearing preservation. Tinnitus improved after cochlear implant treatment in patients with Meniere's disease.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"430-435"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the causal relationship between hypertension and benign paroxysmal vertigo: a univariate and multivariate Mendelian randomization study. 检查高血压和良性阵发性眩晕之间的因果关系：单变量和多变量孟德尔随机化研究。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-23 DOI: 10.1080/00016489.2025.2479015

Luyao Wang, Feilun Cui, Xiangping Chen, Qing Zhang, Jun Yang, Shuna Li

{"title":"Examining the causal relationship between hypertension and benign paroxysmal vertigo: a univariate and multivariate Mendelian randomization study.","authors":"Luyao Wang, Feilun Cui, Xiangping Chen, Qing Zhang, Jun Yang, Shuna Li","doi":"10.1080/00016489.2025.2479015","DOIUrl":"10.1080/00016489.2025.2479015","url":null,"abstract":"Background: Patients with benign paroxysmal positional vertigo (BPPV) may be at increased risk for hypertension.Objectives: To examine the causal relationship between hypertensive disorders and benign paroxysmal vertigo (BPV).Materials and methods: A bidirectional two-sample Mendelian randomization (MR) study was conducted to assess the causal relationship between hypertension and BPV. Summary statistics for BPV and hypertension were obtained from the FinnGen biobank to support the primary MR analysis. Five complementary methods - inverse variance weighted, weighted median, MR-Egger, simple mode, and weighted mode - were applied to obtain MR estimates. Furthermore, a multivariable MR (MVMR) analysis was conducted to examine whether hypertension independently influences BPV.Results: The MR analysis indicated a significant causal effect of hypertension on BPV, with an odds ratio (OR) of 1.11 (95% CI: 1.02-1.22, p = .019), indicating an increased risk of BPV associated with hypertension. MVMR analysis further indicated that the causal effect of hypertension on BPV remained significant even after adjusting for menopausal disorders and ischemic stroke (OR: 1.108, 95% CI: 1.003-1.225, p = .043).Conclusions and significance: This MR study provided evidence supporting a causal effect of hypertension on BPV.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"400-408"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 133-kDa N-terminal region of myosin XVa is critical for normal structure and function of auditory and hair cells. 肌球蛋白XVa的n端133-kDa区域对听细胞和毛细胞的正常结构和功能至关重要。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-24 DOI: 10.1080/00016489.2025.2479632

Yong Li, Yanli Wang, Jiong Dang, Wenjing Zhuo, Baicheng Xu, Yufen Guo

{"title":"The 133-kDa N-terminal region of myosin XVa is critical for normal structure and function of auditory and hair cells.","authors":"Yong Li, Yanli Wang, Jiong Dang, Wenjing Zhuo, Baicheng Xu, Yufen Guo","doi":"10.1080/00016489.2025.2479632","DOIUrl":"10.1080/00016489.2025.2479632","url":null,"abstract":"Background: MYO15A is a commonly implicated gene in severe to profound sensorineural hearing loss. Numerous studies have identified mutations in MYO15A in humans, analyzed their presence and co-segregation, and predicted their pathogenicity using software tools. However, few have investigated the pathogenic mechanisms of these mutations using mouse models. In a prior study, we identified the MYO15A c.2482 C > T mutation as a potential causative gene for deafness in a Uygur family from Xinjiang. To further explore the pathogenicity and mechanisms of this mutation, we constructed a mouse model harboring the Myo15a c.2455A > T mutation. This study demonstrates that mice with the Myo15a c.2455A > T spot knock-in exhibit the abnormal hair cell morphology, dysfunction, and hearing loss phenotype observed in humans.Objectives: To investigate the pathogenic mechanism of deafness caused by MYO15A c.2482C > T mutation.Material and methods: To assess the impact of the MYO15A mutation on hair cell morphology and function, mice underwent audiological tests, quantitative real-time PCR, scanning electron microscopy, immunofluorescence, and Western blot analysis.Results: The p.Arg819* mutation located in the N-terminal domain of MYO15A showed marked differences in hair cell morphology and function between homozygous mutant mice and normal controls. Notably, the homozygous mutant mice retained residual hearing up to approximately five weeks of age.Conclusions and significance: Our findings confirm that Myo15a c.2455A > T spot knock-in mice replicate the abnormal hair cell morphology and dysfunction, as well as the hearing loss phenotype. Additionally, our results indicate that the novel c.2482C > T variant in the MYO15A gene can cause inner ear hair cell dysfunction and audiological disorders in this family.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"363-374"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of nasal functions in Behçet's and neuro-Behçet's patients. behet和神经性behet患者鼻功能的评价。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-01 DOI: 10.1080/00016489.2025.2470981

Sumeyye Gencer Culha, Mansur Dogan

{"title":"Evaluation of nasal functions in Behçet's and neuro-Behçet's patients.","authors":"Sumeyye Gencer Culha, Mansur Dogan","doi":"10.1080/00016489.2025.2470981","DOIUrl":"10.1080/00016489.2025.2470981","url":null,"abstract":"Background: Behçet's disease (BD) is a multisystemic inflammatory disease.Objectives: The aim of our study is to investigate whether BD and neuro-Behçet's disease (ND) cause any changes in nasal and olfactory functions.Materials and methods: Our study included 20 patients with BD (group BD), 17 patients with ND (group NB), and a control group of 20 healthy volunteers (group C). Participants underwent nasal endoscopic examination, peak nasal inspiratory flow (PNIF) test to assess nasal airway patency, saccharin test to measure mucociliary clearance and Sniffin' Sticks smell test to assess olfactory dysfunction.Results: In our study, when the groups were examined in terms of saccharin values, it was found to be statistically significantly longer in group BD and group NB (p < .001). In the odor discrimination test, a statistically significant difference was found only between group NB and group C. The odor identification test and total scores were found to be lower in group BD and group NB.Conclusions and significance: The results obtained in this study demonstrate that mucociliary activity and olfactory functions are significantly impaired in both the BD and NB groups.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"436-442"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of basic-fibroblast growth factor on tympanic membrane perforation in a mouse model of blast injury. 碱性成纤维细胞生长因子对爆炸伤小鼠模型鼓膜穿孔的影响

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-02-28 DOI: 10.1080/00016489.2025.2470971

Motohiro Sato, Kunio Mizutari, Takaomi Kurioka, Yoshiaki Inuzuka, Shingo Yasutake, Koji Araki, Yasushi Satoh, Akihiro Shiotani

{"title":"Effect of basic-fibroblast growth factor on tympanic membrane perforation in a mouse model of blast injury.","authors":"Motohiro Sato, Kunio Mizutari, Takaomi Kurioka, Yoshiaki Inuzuka, Shingo Yasutake, Koji Araki, Yasushi Satoh, Akihiro Shiotani","doi":"10.1080/00016489.2025.2470971","DOIUrl":"10.1080/00016489.2025.2470971","url":null,"abstract":"Background: Tympanic membrane perforation (TMP) caused by blast injury result in poor TMP closure and pathological regeneration of the tympanic membrane (TM). TM regeneration therapy using basic fibroblast growth factor (bFGF) has demonstrated good outcomes for chronic otitis media.Aims/objectives: To investigate the efficacy of bFGF treatment in the management of blast-induced TMP.Material and methods: Male CBA/J mice (10-12-week-old) were divided into the bFGF-treatment and no-treatment groups. Blast-tube systems were used to induce TMP. Auditory evaluation, TM observation, histological evaluation of the regenerated TM, and histological evaluation of the inner ear were conducted.Results: Auditory assessment revealed no difference between the groups, with persistent auditory threshold elevation being observed even 1 month post-injury. Similarly, histological evaluation of the inner ear hair cells revealed no significant differences between the groups; no hair cell death was evident. However, the regenerated TM in the bFGF-treated group was significantly thicker than that in the untreated group.Conclusions and significance: A good TMP closure rate was observed in the present study; however, bFGF treatment exacerbated thickening of the regenerated TM. Future studies must study the therapeutic effects of bFGF treatment using various animal models and timing and concentration of bFGF treatment.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"382-389"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative outcome of palatine tonsillectomy by tonsil pillar suture with knot-free suture. 无结缝合扁桃体柱缝合腭扁桃体切除术后的疗效。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI: 10.1080/00016489.2025.2476191

Yusei Yamaguchi, Shinya Ohira, Kota Wada

{"title":"Postoperative outcome of palatine tonsillectomy by tonsil pillar suture with knot-free suture.","authors":"Yusei Yamaguchi, Shinya Ohira, Kota Wada","doi":"10.1080/00016489.2025.2476191","DOIUrl":"10.1080/00016489.2025.2476191","url":null,"abstract":"Background: Postoperative haemorrhage following palatine tonsillectomy occurs in 5-14% of cases. Since 2021, our department has used knot suturing with 3-0 Vicryl, and from 2023, continuous suturing with the V-Loc™ closure device to reduce suture time. While knot suturing is reported to reduce postoperative bleeding and pain, no studies have compared outcomes between different suture methods.Aims: This study retrospectively analysed postoperative bleeding, pain, and complications in 125 patients undergoing palatine tonsillectomy, with or without sutures.Methods: Patients aged ≥15 years who underwent bilateral tonsillectomy from October 2019 to March 2024 were grouped into no-suture, knot-suture, and knot-free-suture categories. Data on operative time, pain, bleeding, suture dissection, and complications were compared using the Mann-Whitney U test for continuous variables and the chi-square test for nominal variables.Results: Knot-free sutures had the shortest operative time (53 ± 16 min) compared to no sutures (62 ± 19 min) and knot sutures (94 ± 22 min). Pain decreased over time across all groups. Bleeding rates were similar, though knot-free sutures required frequent removal (76%). Knot sutures had a significantly lower dissection rate (<0.001).Conclusions and significance: Knot-free sutures improve surgical efficiency but may require additional postoperative interventions, representing a cost-effective alternative to high-energy devices.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"463-467"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allogeneic composite amniotic membrane in tympanic membrane repair: a randomized parallel controlled study. 同种异体复合羊膜在鼓膜修复中的应用：一项随机平行对照研究。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI: 10.1080/00016489.2025.2475487

Anchi Sun, Rongrong Lv, Zhiwei Xing, Xiaomin Wang, Mingjie Zhang, Mengjun Wang, Qianqian Shao, Hui Li

{"title":"Allogeneic composite amniotic membrane in tympanic membrane repair: a randomized parallel controlled study.","authors":"Anchi Sun, Rongrong Lv, Zhiwei Xing, Xiaomin Wang, Mingjie Zhang, Mengjun Wang, Qianqian Shao, Hui Li","doi":"10.1080/00016489.2025.2475487","DOIUrl":"10.1080/00016489.2025.2475487","url":null,"abstract":"Backgrounds: Composite amniotic membranes have been widely used in ophthalmology and orthopedics. For the repair of tympanic membrane perforation, the introduction of amniotic membrane is still under study.Objectives: To analyse the effectiveness of a homograft composite amniotic membrane in tympanic membrane repair.Methods: A total of 76 patients were recruited and randomly assigned to the experimental group (n = 39) and the control group (n = 37). The test group employed a composite amniotic membrane for the repair of the tympanic membrane, while the control group utilized cartilage from the auricular for the same purpose. The efficacy of composite amniotic membrane was evaluated through a comparative analysis of postoperative tympanic membrane healing, complications, and hearing recovery.Results: Hearing improved significantly in both groups, but there was no significant difference between the two groups. The results of the postoperative pain scores demonstrated that the majority of patients were experiencing mild pain, with a notable discrepancy between the test group and the control group. Intraoperative bleeding time was also significantly lower in the test group than in the control group.Conclusion: Allogeneic composite amniotic membrane can be used as a material for repairing tympanic membrane perforation, which can effectively improve postoperative hearing of patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"424-429"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlating audiological results with location of intracochlear schwannoma assessed by routine and Hydrops MRI. 听力学结果与耳蜗内神经鞘瘤位置的相关性：常规和Hydrops MRI评估。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1080/00016489.2025.2484790

Yen-Ting Guo, Yu-Fen Wang, Yi-Ho Young

{"title":"Correlating audiological results with location of intracochlear schwannoma assessed by routine and Hydrops MRI.","authors":"Yen-Ting Guo, Yu-Fen Wang, Yi-Ho Young","doi":"10.1080/00016489.2025.2484790","DOIUrl":"10.1080/00016489.2025.2484790","url":null,"abstract":"Background: Whether an intracochlear schwannoma (ICS) concomitant with endolymphatic hydrops (EH) remains unclear.Objective: This study had two objectives: first, to correlate the location of ICS with audiological results using routine MRI; and second, to determine whether an ICS is associated with EH using Hydrops MRI.Methods: Four cases with ICS demonstrated by routine MRI underwent an inner ear test battery, followed by 3 T Hydrops MRI.Results: Audiometry revealed total deafness in 2 patients, flat-type hearing loss in one and 2 kHz dip type hearing loss in 1. Routine MRI demonstrated an ICS at cochlear basal turn in 3, and cochlear middle turn in 2 (one case showed ICS at the basal and middle turns). Correlating audiological results with the location of ICS suggests that hearing deterioration may be associated with affected cochlear turn. Hydrops MRI identified Grade II cochlear EH in two ICS patients with vertigo, but not in another two ICS patients without vertigo.Conclusion: For an ICS patient with vertiginous episode, routine MRI along with Hydrops MRI may help identify both the ICS and EH, simultaneously.Significance: A 'wait and scan' approach, which includes routine MRI along with Hydrops MRI, is recommended for the follow-up of ICS patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"409-414"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preservation of waves VI and VII of ABR in pediatric and adult patients with lesions in bilateral auditory cortices or radiations. 双侧听皮质损伤或放疗的儿童和成人患者的ABR波VI和VII的保存。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1080/00016489.2025.2475052

Ryohei Akiyoshi, Kimitaka Kaga

{"title":"Preservation of waves VI and VII of ABR in pediatric and adult patients with lesions in bilateral auditory cortices or radiations.","authors":"Ryohei Akiyoshi, Kimitaka Kaga","doi":"10.1080/00016489.2025.2475052","DOIUrl":"10.1080/00016489.2025.2475052","url":null,"abstract":"Background: Auditory-evoked brainstem response (ABR) is widely used in various areas of clinical medicine. There is a common understanding regarding the origins of waves I to V in human ABR. However, little is known from where wave VI or VII originates in the central auditory pathway.Aims/objectives: The aim of our research is to elucidate the origins of waves VI and VII by studying ABR amplitude and latency and conducting magnetic resonance imaging (MRI).Materials and methods: Eleven patients diagnosed as having central auditory disorders participated in this study. They include five pediatric patients with herpes simplex infection and six adult patients with cerebrovascular events manifesting auditory agnosia or cortical deafness with lesions in the bilateral auditory cortices.Results: We found that waves VI and VII formed into one complex wave with biphasic peaks and the origin of these waves can be the medial geniculate body (MGB).Conclusions: On the basis of anatomical and electrophysiological findings, we suggest that the latency of VI-I or VII-I nerve conduction time is the auditory brainstem-thalamus transmission time.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"415-423"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of single versus multiple surgeries in CRSwNP patients undergoing treatment with dupilumab. 单次手术与多次手术对接受dupilumab治疗的CRSwNP患者的影响

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-23 DOI: 10.1080/00016489.2025.2481233

Matteo Alicandri-Ciufelli, Carla Cantaffa, Costanza Galloni, Ignazio Javier Fernandez, Daniele Marchioni, Carlotta Pipolo, Massimiliano Garzaro, Letizia Nitro, Valeria Dell'Era, Francesco Ferella, Massimo Campagnoli, Paolo Russo, Angelo Ghidini, Eugenio De Corso, Daniela Lucidi

{"title":"Impact of single versus multiple surgeries in CRSwNP patients undergoing treatment with dupilumab.","authors":"Matteo Alicandri-Ciufelli, Carla Cantaffa, Costanza Galloni, Ignazio Javier Fernandez, Daniele Marchioni, Carlotta Pipolo, Massimiliano Garzaro, Letizia Nitro, Valeria Dell'Era, Francesco Ferella, Massimo Campagnoli, Paolo Russo, Angelo Ghidini, Eugenio De Corso, Daniela Lucidi","doi":"10.1080/00016489.2025.2481233","DOIUrl":"10.1080/00016489.2025.2481233","url":null,"abstract":"Background: Prior to the introduction of biologic drugs, the natural history of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) was characterized by multiple recurrences, thus necessitating multiple surgical interventions.Aims/objectives: To understand whether Dupilumab efficacy in recurrent CRSwNP varies based on number of previous surgeries.Materials and methods: This is a multicentric retrospective study on patients with CRSwNP under Dupilumab, who underwent at least one previous surgery. Correlations between number of previous surgeries and clinical outcomes at baseline and during treatment were investigated.Results: 141 patients were included. Mean number of prior surgeries was 2.19 (median 2; range 1-13). For all patients, significant improvements were observed across all time points. Poorer results were observed in patients subjected to more than one prior surgery in terms of NPS at T2 (p .04), SNOT-22 at T4 (p .03), VAS for olfactory dysfunction at T3 (p .01) and T5 (p .009), VAS for nasal obstruction at T4 (p .047), VAS for rhinorrhea at T4 (p .02), VAS for craniofacial pain at T1 (p .02) and T2 (p .04) and of VAS for sleep disturbances at T1 (p .04).Conclusions and significance: Patients subjected to multiple surgeries have worse outcomes during treatment with Dupilumab, particularly for what concerns craniofacial pain and olfactory dysfunction.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"450-456"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0