Acta Oto-Laryngologica最新文献_第2页

Trends in the incidence and prevalence of juvenile-onset recurrent respiratory papillomatosis following implementation of national HPV vaccination initiatives: a systematic review.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.1080/00016489.2024.2431548

Ida-Marie Jacobsen, Amanda-Louise Fenger Carlander, Mathilde Aakilde, Christian von Buchwald

{"title":"Trends in the incidence and prevalence of juvenile-onset recurrent respiratory papillomatosis following implementation of national HPV vaccination initiatives: a systematic review.","authors":"Ida-Marie Jacobsen, Amanda-Louise Fenger Carlander, Mathilde Aakilde, Christian von Buchwald","doi":"10.1080/00016489.2024.2431548","DOIUrl":"10.1080/00016489.2024.2431548","url":null,"abstract":"Background: Infection with human papillomavirus (HPV) low-risk type 6 and 11 in the respiratory tract can cause recurrent benign squamous papillomas in the larynx, in children, juvenile-onset recurrent respiratory papillomatosis (JoRRP).Objectives: This systematic review investigated the impact of national HPV vaccination programs on JoRRP incidence and prevalence.Methods: PubMED was systematically searched for publications between 2010 and March 2024 that assessed the incidence and prevalence of JoRRP post-implementation of HPV vaccination programs.Results: Four studies met the inclusion criteria, comprising 622 patients with JoRRP (range 15-576) from Australia, New Zealand and the Unites States. The majority were girls (F:M ratio 2:1), with a median debut age between three to four years. Two studies (n = 591) showed a significant decline in JoRRP incidence after vaccination from 2,0 per 100,000 < 18 years (2004-2005) to 0,5 per 100,000 < 18 years (2012-2013) in the United States, and 0,16 per 100,000 < 15 years (2012) to 0,02 per 100,000 < 15 years (2016) in Australia. Higher vaccination coverage correlated with a reduced JoRRP burden.Conclusion: Our findings indicate implementation of HPV-vaccination programs reduced the JoRRP incidence and prevalence emphasizing the importance of large-scale HPV vaccination. Total impact of HPV vaccination will become fully evident when the vaccinated population reach childbearing ages.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"66-71"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymph node density as prognostic factor in regional recurrent or residual head and neck cancer.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.1080/00016489.2024.2432505

Seiya Goto, Hidenori Suzuki, Shintaro Beppu, Daisuke Nishikawa, Michi Sawabe, Hoshino Terada, Nobuhiro Hanai, Michihiko Sone

{"title":"Lymph node density as prognostic factor in regional recurrent or residual head and neck cancer.","authors":"Seiya Goto, Hidenori Suzuki, Shintaro Beppu, Daisuke Nishikawa, Michi Sawabe, Hoshino Terada, Nobuhiro Hanai, Michihiko Sone","doi":"10.1080/00016489.2024.2432505","DOIUrl":"10.1080/00016489.2024.2432505","url":null,"abstract":"Background: Prognostic factors from neck dissection for regional recurrent or residual head and neck cancer remain undetermined.Aims/objectives: We studied whether continuous variables from pathologic lymph nodes of salvage neck dissection could estimate survival outcomes in patients with head and neck squamous cell carcinomas (HNSCC).Materials and methods: Pathologic continuous variables from neck dissection without primary tumor resection in 184 patients with HNSCC were retrospectively evaluated. Cutoff values from both lymph node density (LND) and log odds of positive lymph nodes (LODDS) as the variables were applied to death estimation. Uni-/multivariate survival analyses adjusting for pathologic N classification and extranodal extension were evaluated by log-rank test or Cox's proportional hazard model, respectively.Results: LND ≥ 0.14 and LODDS ≥ -1.72 were significantly related to univariate shorter survival outcomes. Multivariate analysis indicated a significant association between LND ≥ 0.14 and shorter overall (hazard ratio [HR] = 2.16, 95% confidence interval [CI] = 1.30-3.58), local recurrence-free (HR = 2.34, 95% CI = 1.06-5.16), regional recurrence-free (HR = 2.32, 95% CI = 1.27-4.25), and distant metastasis-free survival (HR = 2.17, 95% CI = 1.31-3.61).Conclusions and significance: Based on the obtained results, increased LND was a poor prognostic factor following salvage neck dissection.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"81-87"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-surgical changes in wideband absorbance in paediatric cochlear implant users after mastoidectomy and posterior tympanotomy.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-12-30 DOI: 10.1080/00016489.2024.2437552

Maraiah Mamatha Nerale, Bansode Rohit Raghunath, Arunraj Karuppannan

{"title":"Post-surgical changes in wideband absorbance in paediatric cochlear implant users after mastoidectomy and posterior tympanotomy.","authors":"Maraiah Mamatha Nerale, Bansode Rohit Raghunath, Arunraj Karuppannan","doi":"10.1080/00016489.2024.2437552","DOIUrl":"https://doi.org/10.1080/00016489.2024.2437552","url":null,"abstract":"Background: Although Cochlear implantation (CI) is effective in restoring hearing for children with severe-to-profound sensorineural hearing loss, it may influence the middle ear mechanics, potentially causing an air-bone gap and altering middle ear stiffness, which is not detected by traditional 226 Hz tympanometry.Aims/objectives: To investigate the effect of mastoidectomy posterior tympanotomy (MPTA) on wideband absorbance (WBA) in children with CI.Materials and methods: The study included 20 normal-hearing children (normal group) and 10 children with CIs who underwent MPTA (CI-MPTA group), aged 3-10 years. WBA at peak and ambient pressure, resonance frequency, and 226 Hz tympanometry were measured.Results: The normal group showed maximum absorbance at 1250 and 3000 Hz, whereas the CI-MPTA group had a single peak at 3000 Hz. The CI-MPTA group exhibited reduced absorbance at low and mid-frequencies (250-1500 Hz), with significant differences (p < 0.05) observed at 800-1250 Hz for peak pressure and 1000-1250 Hz for ambient pressure. No significant differences were found in resonance frequency or 226 Hz tympanometry.Conclusions and significance: CI with MPTA changes middle ear absorbance patterns, affecting the low- and mid-frequency regions. These findings indicate the importance of using WBA tympanometry to monitor middle and inner ear mechanics post-CI.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"145 1","pages":"43-50"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between Lund-Mackay computed tomography score and subjective symptoms in Chinese patients with nasal polyps. 中国鼻息肉患者的 Lund-Mackay 计算机断层扫描评分与主观症状之间的相关性。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-10-21 DOI: 10.1080/00016489.2024.2412720

Qianqian Zhang, Chen Zhang, Jiani Chen, Le Shi, Yingqi Gao, Yumin Zhou, Fuying Cheng, Dehui Wang, Huan Wang, Xicai Sun, Li Hu

{"title":"Correlation between Lund-Mackay computed tomography score and subjective symptoms in Chinese patients with nasal polyps.","authors":"Qianqian Zhang, Chen Zhang, Jiani Chen, Le Shi, Yingqi Gao, Yumin Zhou, Fuying Cheng, Dehui Wang, Huan Wang, Xicai Sun, Li Hu","doi":"10.1080/00016489.2024.2412720","DOIUrl":"10.1080/00016489.2024.2412720","url":null,"abstract":"Background: The association between objective imaging findings and subjective symptoms remains undefined.Aims: To investigate the correlation between objective imaging findings and symptom severity in the overall chronic rhinosinusitis with nasal polyps (CRSwNP) population as well as its subendotypes according to the eosinophilic inflammation.Methods: Patients with CRSwNP undergoing endoscopic sinus surgery were included. All participants completed the Sino-Nasal Outcome Test (SNOT-22) questionnaire. The Lund-Mackay (LM) CT scores was also obtained. Spearman correlation analysis was performed to evaluate the correlation between CT scores and SNOT-22 scores.Results: Forty-four non-eosinophilic CRSwNP(neCRSwNP) and 93 eosinophilic CRSwNP (eCRSwNP) patients were recruited. There was significant association between LM total score and nasal subdomain of SNOT-22 in the overall CRSwNP patients. The nasal symptom of SNOT-22 was significantly associated with maxillary, frontal, sphenoid, anterior drainage, and posterior drainage in all CRSwNP patients. In eCRSwNP and neCRSwNP patients, the sense of smell/taste was associated with sphenoid and posterior drainage. Thick nasal discharge was positively correlated with maxillary, frontal, and anterior drainage only in eCRSwNP patients.Conclusions: The high score of sphenoid and posterior drainage may suggest the occurrence of loss of sense of smell/taste, while high score of maxillary sinus may indicate suffering from thick nasal discharge in eCRSwNP patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"59-65"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Somatic genetic alterations of oncogenes and tumor suppressor genes in cholesteatoma.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-12-08 DOI: 10.1080/00016489.2024.2433138

Levent Şimşek, M Selman Yıldırım, Çağatay Han Ülkü, Ayşe Gül Zamani

{"title":"Somatic genetic alterations of oncogenes and tumor suppressor genes in cholesteatoma.","authors":"Levent Şimşek, M Selman Yıldırım, Çağatay Han Ülkü, Ayşe Gül Zamani","doi":"10.1080/00016489.2024.2433138","DOIUrl":"10.1080/00016489.2024.2433138","url":null,"abstract":"Background: Cholesteatoma is a proliferative disease that affects the tympanic cavity and temporal bone. Despite many studies and various theories, the etiopathogenesis of cholesteatoma has not been fully elucidated. Features such as invasion, migration, uncontrolled proliferation, and lack of differentiation are observed in both cholesteatoma and neoplasia.Aims/objectives: The aim of this study is to investigate somatic genetic alterations in known proto-oncogenes and tumor suppressor genes in cholesteatoma.Material and methods: 60 different known proto-oncogenes and tumor suppressor genes were comparatively analyzed in cholesteatoma and peripheric blood samples from 15 middle ear cholesteatoma patients using next-generation sequencing.Results: JAK3 c.2164G > A, TP53 c.284delC, and KRAS c.377A > T alterations were observed in cholesteatoma tissue but not in normal tissue. In addition, 12 different germline variants were also identified in 8 patients.Conclusions and significance: In this study, the presence of changes in cancer-related genes in cholesteatoma was determined and these changes were discussed in terms of possible clinical applications. We hope that the genetic alterations that emerged in this study, will be beneficial in guiding future research in this field.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"16-22"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ototoxic effects of unilateral postauricular neomycin administration on the inner ears of Guinea pigs.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1080/00016489.2024.2436076

Nishan Chen, Tongxiang Diao, Jilei Zhang, Lisheng Yu

{"title":"Ototoxic effects of unilateral postauricular neomycin administration on the inner ears of Guinea pigs.","authors":"Nishan Chen, Tongxiang Diao, Jilei Zhang, Lisheng Yu","doi":"10.1080/00016489.2024.2436076","DOIUrl":"10.1080/00016489.2024.2436076","url":null,"abstract":"Backgrounds: Due to the therapeutic needs of inner ear diseases, a simple method of inner ear drug delivery has been under exploration. Postauricular administration, which involves injecting the drug through the middle of the retroauricular groove, is a potential novel approach, but its mechanisms remain unclear.Objectives: To investigate threshold shifts in the auditory brainstem response (ABR), as well as the morphology and quantity of hair cells on the bilateral inner ear of guinea pigs after postauricular neomycin administration.Material and methods: Thirty healthy guinea pigs were divided randomly into two groups and administered either neomycin 200 mg/kg or saline 1 ml via daily postauricular injection for 10 days. Auditory threshold-shifts were examined by tests of the ABR. The quantity and morphology of hair cells in the organ of Corti were assessed by confocal laser scanning microscopy.Results: The ABR results showed that at a frequency of 16 kHz, the threshold shift was 21.00 ± 14.49 dB in the neomycin injection side, 10.00 ± 16.67 dB in the contralateral side, and 0.50 ± 3.69 dB in the saline group. At a frequency of 24 kHz, the threshold shift was 37.00 ± 16.36 dB in the neomycin injection side, 14.50 ± 9.26 dB in the contralateral side, and 1.00 ± 2.11 dB in the saline group. Histopathological analysis revealed that the outer hair cells (OHCs) in the neomycin injection side suffered significant morphological and numerical loss, while the OHC loss in the contralateral ear was less severe than in the injection side but greater than in the saline group.Conclusions and significance: This study confirms that postauricular administration is a novel method of local drug delivery to the inner ear, which has practical value in future experimental modeling and the treatment of inner ear diseases.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"93-100"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collaborative machine learning-guided overall survival prediction of oral squamous cell carcinoma. 以机器学习为指导的口腔鳞状细胞癌总体生存率协作预测。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-12-31 DOI: 10.1080/00016489.2024.2437012

Rasheed Omobolaji Alabi, Mohammed Elmusrati, Ilmo Leivo, Alhadi Almangush, Antti A Mäkitie

{"title":"Collaborative machine learning-guided overall survival prediction of oral squamous cell carcinoma.","authors":"Rasheed Omobolaji Alabi, Mohammed Elmusrati, Ilmo Leivo, Alhadi Almangush, Antti A Mäkitie","doi":"10.1080/00016489.2024.2437012","DOIUrl":"https://doi.org/10.1080/00016489.2024.2437012","url":null,"abstract":"Background: There is a lack of prognosticators of overall survival (OS) for Oral Squamous Cell Carcinoma (OSCC).Objectives: We examined collaborative machine learning (cML) in estimating the OS of OSCC patients. The prognostic significance of the clinicopathological parameters was examined.Methodology: Altogether, 9439 OSCC patients were extracted from the Surveillance, Epidemiology, and End Results database (US). Five ML models - voting ensemble, stacked ensemble, extreme gradient boosting, light boosting, and logistic regression were used to predict OS. Three of these ML algorithms were combined to form a cluster of cML models. The performance of the cML was compared with the best performing individual ML algorithm following model training.Results: The performance accuracy of the voting ensemble, stacked ensemble, extreme gradient boosting, light boosting, and logistic regression models was 70.2%, 69.9%, 69.1%, 69.4%, and 69.5% respectively, following model training. When the voting ensemble model was compared with cML using temporal validation, the cML showed a comparable performance accuracy. The most significant prognostic factors were age of the patient at diagnosis, T stage, tumor grade, marital status, gender, primary site, surgery, N stage, radiotherapy, ethnicity, chemotherapy, and M stage.Conclusions: cML appears to give reliability to the final prediction and thereby may mark a paradigm shift from model individualism to a more cooperative paradigm. This approach may aid in determining an enhanced individualized treatment for OSCC patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence for optimizing otologic surgical video: effects of video inpainting and stabilization on microscopic view.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-12-06 DOI: 10.1080/00016489.2024.2435448

Hye Ah Joo, Kanggil Park, Jun-Sik Kim, Young Hyun Yun, Dong Kyu Lee, Seung Cheol Ha, Namkug Kim, Jong Woo Chung

{"title":"Artificial intelligence for optimizing otologic surgical video: effects of video inpainting and stabilization on microscopic view.","authors":"Hye Ah Joo, Kanggil Park, Jun-Sik Kim, Young Hyun Yun, Dong Kyu Lee, Seung Cheol Ha, Namkug Kim, Jong Woo Chung","doi":"10.1080/00016489.2024.2435448","DOIUrl":"https://doi.org/10.1080/00016489.2024.2435448","url":null,"abstract":"Background: Optimizing the educational experience of trainees in the operating room is important; however, ear anatomy and otologic surgery are challenging for trainees to grasp. Viewing otologic surgeries often involves limitations related to video quality, such as visual disturbances and instability.Objectives: We aimed to (1) improve the quality of surgical videos (tympanomastoidectomy [TM]) by using artificial intelligence (AI) techniques and (2) evaluate the effectiveness of processed videos through a questionnaire-based assessment from trainees.Materials and methods: We conducted prospective study using video inpainting and stabilization techniques processed by AI. In each study set, we enrolled 21 trainees and asked them to watch processed videos and complete a questionnaire.Results: Surgical videos with the video inpainting technique using the implicit neural representation (INR) model were found to be the most helpful for medical students (0.79 ± 0.58) in identifying bleeding focus. Videos with the stabilization technique via point feature matching were more helpful for low-grade residents (0.91 ± 0.12) and medical students (0.78 ± 0.35) in enhancing overall visibility and understanding surgical procedures.Conclusions and significance: Surgical videos using video inpainting and stabilization techniques with AI were beneficial for educating trainees, especially participants with less anatomical knowledge and surgical experience.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testing for genetic and viral etiologies in congenital hearing loss based on a survey of cochlear implant centers: proposed HEARRING group consensus and future directions. 基于人工耳蜗植入中心调查的先天性听力损失基因和病毒病因测试：HEARRING 小组的共识建议和未来方向。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-10-25 DOI: 10.1080/00016489.2024.2414803

Shin-Ichi Usami, Shin-Ya Nishio, Javier Gavilán, Aanand Acharya, Abdulrahman Hagr, Luis Lassaletta, Yongxin Li, S Sudha Maheshwari, Mohan Kameswaran, Thomas Parzefall, Chris Raine, Kristen Rak, Anne Morgan Selleck, Hinrich Staecker, Timo Stöver, Serafima Sugarova, Vedat Topsakal, Vincent Van Rompaey, Griet Mertens, Stefan Volkenstein, Christiane Völter, Wafaa Shehata-Dieler, Mario E Zernotti, Paul Van de Heyning

{"title":"Testing for genetic and viral etiologies in congenital hearing loss based on a survey of cochlear implant centers: proposed HEARRING group consensus and future directions.","authors":"Shin-Ichi Usami, Shin-Ya Nishio, Javier Gavilán, Aanand Acharya, Abdulrahman Hagr, Luis Lassaletta, Yongxin Li, S Sudha Maheshwari, Mohan Kameswaran, Thomas Parzefall, Chris Raine, Kristen Rak, Anne Morgan Selleck, Hinrich Staecker, Timo Stöver, Serafima Sugarova, Vedat Topsakal, Vincent Van Rompaey, Griet Mertens, Stefan Volkenstein, Christiane Völter, Wafaa Shehata-Dieler, Mario E Zernotti, Paul Van de Heyning","doi":"10.1080/00016489.2024.2414803","DOIUrl":"10.1080/00016489.2024.2414803","url":null,"abstract":"Background: In cases of congenital sensorineural hearing loss, testing for genetic etiologies and congenital cytomegalovirus (cCMV) infection have become common practice.Aims/objectives: The purpose of this study is to determine which specific testing methodologies should be used and when.Material and methods: We surveyed 20 practicing otolaryngologists across eighteen institutions in thirteen countries about their approach to cCMV, GJB2, and wider genetic testing.Results: We found 90% of respondents employ all three tests, either in routine or special cases. cCMV testing is widely used, with 95% of respondents incorporating it into their clinical practice. GJB2 testing was employed by 90%. In cases with negative GJB2 test results, a majority of respondents proceeded to wider genetic screening. Test reimbursement was also examined for each test. For cCMV testing, 63.1% reported reimbursement, 68.4% reported reimbursement for GJB2 variant testing and 52.6% reported reimbursement for wider genetic screening.Conclusions and significance: A common approach is to perform cCMV and GJB2 testing as the first tests, followed by wider genetic testing. This study offers insight into the prevalence, methodologies, and reimbursement status of these testing methodologies across multiple hearing centers and countries. Current consensus and future directions are described based on the current survey.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"602-609"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hearing and balance functions in adults with ıron deficiency. 患有ı铁缺乏症的成年人的听力和平衡功能。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-11-27 DOI: 10.1080/00016489.2024.2428260

Serpil Demir, Alper Köycü, Selim S Erbek

{"title":"Hearing and balance functions in adults with ıron deficiency.","authors":"Serpil Demir, Alper Köycü, Selim S Erbek","doi":"10.1080/00016489.2024.2428260","DOIUrl":"10.1080/00016489.2024.2428260","url":null,"abstract":"Background: Because the inner ear requires high-energy metabolism and because of the iron content of some cochlear enzymes, iron deficiency-related hypoxia can affect hearing and the balance system.Objectives: To evaluate the hearing and balance functions in adults with iron deficiency (ID) and iron deficiency anemia (IDA).Material and methods: 22 ID patients, 22 IDA patients and 22 healthy controls underwent pure tone audiometry (0.125-16 kHz), VNG, VEMP, and vHIT.Results: Significant differences were observed in the hearing thresholds of the IDA group at frequencies ranging from 0.125 kHz to 14 kHz, as well as in the ID group at frequencies of 2.0 kHz, 4.0 kHz, and 6.0 kHz. The pursuit test was pathological at the rate of 40.9% in the IDA group. The oVEMP test showed prolonged latency values in both ID and IDA groups. IDA group had lower p1-n1 amplitude than the control group in the oVEMP and cVEMP tests. A significant difference was determined between the groups concerning anterior SCC VOR gains.Conclusions and significance: The hypoxia caused by anemia might negatively impact hearing and vestibular functions. The current study is the first study to comprehensively evaluate anemia patients with VNG, VEMP, and vHIT tests.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"620-626"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0