Acta Oto-Laryngologica最新文献_第3页

Minigene assay for verifying the splicing effects of the rare variants in the SLC12A2 gene at c.2930-1G>a. 验证SLC12A2基因中罕见变异体在c.2930-1G>a处剪接效应的迷你基因试验。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1080/00016489.2025.2475486

Lin Mengsi, Zhu Qingwen, Cui Aimin, Wang Jing

{"title":"Minigene assay for verifying the splicing effects of the rare variants in the SLC12A2 gene at c.2930-1G>a.","authors":"Lin Mengsi, Zhu Qingwen, Cui Aimin, Wang Jing","doi":"10.1080/00016489.2025.2475486","DOIUrl":"10.1080/00016489.2025.2475486","url":null,"abstract":"Background: Hearing loss (HL) is a prevalent sensory impairment with a genetic basis. The SLC12A2 gene, encoding NKCC1, is vital for inner ear ion balance. The c.2930-1G > A variant is a novel mutation potentially linked to sensorineural hearing loss.Objectives: To investigate the splicing and protein expression effects of the c.2930-1G>A variant in SLC12A2 and its role in hearing loss.Material and methods: Minigene assays and plasmid transfection in HEK-293T and Hela cells were used to study splicing. Protein expression and modification were also assessed.Results: The c.2930-1G>A variant caused partial exon skipping, altering mRNA splicing in both cell types. This suggests a potential involvement in sensorineural hearing loss. Protein analysis showed the E21del mutation increased expression without altering modification patterns, whereas the 2930_2977del mutation reduced both, possibly impacting stability or modification sites.Conclusions and significance: The c.2930-1G>A variant likely contribute to hearing loss by disrupting splicing and protein expression. Currently a Variant of Uncertain Significance (VUS), its pathogenicity is supported by these findings. Further research is needed to confirm its role, emphasizing the need for integrated genetic and clinical data in auditory disorders management.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"375-381"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of functional and aesthetic outcomes following open technique septorhinoplasty: assessing the utility and correlation of the Rhinoplasty Health Inventory and Nasal Outcomes, Rhinoplasty Outcome Evaluation, and Nasal Obstructive Symptom Evaluation questionnaires. 开放性鼻中隔成形术后功能和美学结果的评估：评估鼻整形健康量表和鼻结局、鼻整形结果评估和鼻阻塞症状评估问卷的效用和相关性

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI: 10.1080/00016489.2025.2477210

Gamze Ozturk Yilmaz, Gokhan Yilmaz

{"title":"Evaluation of functional and aesthetic outcomes following open technique septorhinoplasty: assessing the utility and correlation of the Rhinoplasty Health Inventory and Nasal Outcomes, Rhinoplasty Outcome Evaluation, and Nasal Obstructive Symptom Evaluation questionnaires.","authors":"Gamze Ozturk Yilmaz, Gokhan Yilmaz","doi":"10.1080/00016489.2025.2477210","DOIUrl":"10.1080/00016489.2025.2477210","url":null,"abstract":"Background: The importance of subjective quality of life questionnaires in evaluating post-rhinoplasty outcomes and patient satisfaction is increasing.Objective: This study aimed to measure the aesthetic and functional satisfaction of patients following septorhinoplasty using the Rhinoplasty Health Inventory and Nasal Outcomes (RHINO), Rhinoplasty Outcome Evaluation (ROE), and Nasal Obstructive Symptom Evaluation (NOSE) questionnaires.Methods: This prospective study included 306 patients who underwent a primary open-technique septorhinoplasty. The NOSE, ROE, and RHINO questionnaires were given to all patients before surgery and in the sixth month following surgery.Results: Preoperative NOSE, ROE, and RHINO scores significantly improved postoperatively in all patients (p < .001). Postoperative satisfaction was higher among young people, women, those with functional indications, single people, and those who were unemployed. Additionally, positive correlation existed between the RHINO and ROE scores (p < .001), and negative correlation existed between the postoperative RHINO and NOSE scores (p < .001).Conclusions: Thus, septorhinoplasty likely improves the functional and aesthetic quality of life in all patients. Our results suggest that a patient who scores favorable on the NOSE and ROE questionnaires is also likely to score favorable on the RHINO questionnaire.Significance: It is possible to evaluate septorhinoplasty results both functionally and aesthetically using just one questionnaire.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"443-449"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of surgical intervention for chronic suppurative otitis media in patients with hematologic diseases. 血液病合并慢性化脓性中耳炎的外科治疗效果评价。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1080/00016489.2025.2471940

Ai Wang, Qingfeng Li, Hongwei Zheng, Lin Han, Jinmei Xue, Lisheng Yu

{"title":"Evaluation of surgical intervention for chronic suppurative otitis media in patients with hematologic diseases.","authors":"Ai Wang, Qingfeng Li, Hongwei Zheng, Lin Han, Jinmei Xue, Lisheng Yu","doi":"10.1080/00016489.2025.2471940","DOIUrl":"10.1080/00016489.2025.2471940","url":null,"abstract":"Objective: To evaluate the effectiveness and safety of surgical treatment for chronic suppurative otitis media (CSOM) in patients with hematologic diseases.Methods: This retrospective study included 26 patients (16 males and 10 females; median age of 36.5 years) with CSOM and hematological diseases treated over three years. All patients received chemotherapy before surgery. Preoperative symptoms included hearing loss accompanied by intermittent ear discharge, ear pain, and dizziness, but no facial paralysis. Surgical indications were recurrent infections, invasive fungal otitis during chemotherapy, or planned hematopoietic stem cell transplantation. Based on the extent of the lesions and intraoperative conditions.Results: All surgeries were successful with a median duration of 70.5 (36-120) minutes and intraoperative blood loss of < 20 mL, without postoperative complications. Hospital stay averaged 9 (8-15) days. During the 6-24-month follow-up, one patient experienced a recurrence of CSOM, and one died from worsening hematologic disease. The remaining patients recovered well and continued to receive appropriate hematologic treatment.Conclusions: Surgical treatment is a safe and effective option for patients with CSOM and hematologic diseases. It can improve patient outcomes and facilitate ongoing and subsequent hematologic cure.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"390-394"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of polysomnography data and inflammatory markers after sleep surgery. 睡眠手术后多导睡眠图数据与炎症标志物的相关性。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1080/00016489.2025.2470304

Öznur Gündüz, Şeyda Akbal Çufalı

{"title":"Correlation of polysomnography data and inflammatory markers after sleep surgery.","authors":"Öznur Gündüz, Şeyda Akbal Çufalı","doi":"10.1080/00016489.2025.2470304","DOIUrl":"10.1080/00016489.2025.2470304","url":null,"abstract":"Background: The occurrence of hypoxia during apneas and hypopneas is associated with the triggering of an inflammatory response.Objectives: This study investigates the alterations in polysomnography (PSG) data, inflammatory markers, and the correlation between these alterations in patients undergoing sleep surgery.Methods: The data of 66 patients who underwent drug-induced sleep endoscopy followed by appropriate sleep surgery, with follow-up PSG performed at 3 to 6 months postoperatively, were retrospectively analyzed. Additionally, correlations with inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), eosinophil-to-lymphocyte ratio (ELR) and systemic immune-inflammation index (SII), were investigated.Results: Comparison of preoperative and postoperative inflammatory markers revealed statistically significant reductions in NLR, PLR, and SII (p < 0.001, p = 0.023, p = 0.026, respectively). Significant positive correlations were identified between AHI and NLR (p = 0.001, r = 0.400), PLR (p = 0.001, r = 0.415) and SII (p = 0.010, r = 0.392). Similarly, a significant positive correlation was observed between supine AHI and NLR (p = 0.035, r = 0.379), PLR (p = 0.008, r = 0.325), and SII (p = 0.030, r = 0.367). The time spent with SaO2 below 90% was found to be significantly and positively correlated with NLR (p = 0.023, r = 0.279), PLR (p = 0.027, r = 0.272), and SII (p = 0.033, r = 0.256).Conclusions and significance: A correlation was observed between the postoperative decrease in SII, NLR, and PLR values and PSG data in patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"457-462"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Audiological findings in patients with leprosy. 麻风病患者的听力学发现。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1080/00016489.2025.2482170

Mahmut Uzut, Senem Erdur Uzut, Fatma Tülin Kayhan, Levent Küfeciler, Zübeyde Elmalı

{"title":"Audiological findings in patients with leprosy.","authors":"Mahmut Uzut, Senem Erdur Uzut, Fatma Tülin Kayhan, Levent Küfeciler, Zübeyde Elmalı","doi":"10.1080/00016489.2025.2482170","DOIUrl":"10.1080/00016489.2025.2482170","url":null,"abstract":"Background: Leprosy, caused by Mycobacterium leprae, is a chronic infectious disease primarily affecting the skin and nervous system. The vestibulocochlear nerve may also be impacted, potentially leading to auditory dysfunction.Aims/objectives: This study investigates the effects of leprosy on the vestibulocochlear nerve and its impact on auditory function through a comprehensive audiological evaluation.Material and methods: A total of 15 leprosy patients and 15 healthy individuals were included. Audiological assessments were conducted at a tertiary care hospital. All participants underwent pure-tone audiometry, speech audiometry, tympanometry, acoustic reflex testing, otoacoustic emissions (OAE), and brainstem auditory evoked response (BERA) tests. Hearing thresholds, wave latencies, and neural conduction were analyzed.Results: Hearing thresholds were significantly higher in leprosy patients than in the control group. BERA results showed a significant prolongation of wave I and wave III latencies in leprosy patients, indicating dysfunction at the level of the acoustic nerve and superior olivary complex.Conclusions and significance: Leprosy may contribute to auditory dysfunction by affecting the myelin sheath of the peripheral and central nervous systems. These findings provide insight into the impact of leprosy on the vestibulocochlear nerve and emphasize the importance of audiological evaluation in leprosy patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"395-399"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The postoperative relief of vertigo and migraine in Meniere's disease patients with and without migraine. 伴有和不伴有偏头痛的梅尼埃病患者术后眩晕和偏头痛的缓解。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-30 DOI: 10.1080/00016489.2025.2491651

Lin Han, Zijing Wang, Junbo Zhang, Maoli Duan, Tongxiang Diao, Lisheng Yu

{"title":"The postoperative relief of vertigo and migraine in Meniere's disease patients with and without migraine.","authors":"Lin Han, Zijing Wang, Junbo Zhang, Maoli Duan, Tongxiang Diao, Lisheng Yu","doi":"10.1080/00016489.2025.2491651","DOIUrl":"https://doi.org/10.1080/00016489.2025.2491651","url":null,"abstract":"Background: The correlation of Meniere's disease (MD) and migraine remains unclear.Objectives: To explore the relation of MD and migraine by analyzing the postoperative relief of vertigo and migraine in MD patients with migraine.Material and methods: 104 MD patients were enrolled. The monthly vertigo episodes (MVE) and migraine headache index (MHI) were used for assessing effectiveness at pre- and post-endolymphatic sac decompression (ELSD). First, patients were divided into MD with migraine and MD two groups with vertigo relief rates compared. Then, the postoperative relief of vertigo and migraine in MD patients with migraine was analyzed.Results: The postoperative vertigo relief rates for MD and MD with migraine groups were 46.7% and 40.68% with no significant difference. In MD patients with migraine, postoperative MVE and MHI decreased significantly. The Kappa value calculated for vertigo and migraine outcomes was 0.505. The absence of hypertension was independently predictive of relief of vertigo and migraine. The male was independently predictive for relief of migraine.Conclusions and significance: ELSD is effective for MD patients with migraine. The postoperative relief of vertigo and migraine has a certain consistency, suggesting MD and migraine may share some common pathogenesis which may be related to inflammation.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supraglottoplasty and thriving in laryngomalacia. Is there a nexus? 声门上成形术治疗喉软化。两者之间有联系吗？

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-23 DOI: 10.1080/00016489.2025.2488487

Patrícia Silva Sousa, Gil Coutinho, António Andrade, Ricardo Vaz, Carla Pinto Moura, Jorge Spratley

{"title":"Supraglottoplasty and thriving in laryngomalacia. Is there a nexus?","authors":"Patrícia Silva Sousa, Gil Coutinho, António Andrade, Ricardo Vaz, Carla Pinto Moura, Jorge Spratley","doi":"10.1080/00016489.2025.2488487","DOIUrl":"https://doi.org/10.1080/00016489.2025.2488487","url":null,"abstract":"Background: Feeding difficulties and failure to thrive are common findings in severe laryngomalacia.Aims: To evaluate the outcomes of supraglottoplasty for severe laryngomalacia and its impact on weight progression.Material and methods: Observational cohort study of paediatric patients with laryngomalacia who underwent supraglottoplasty from 2018 to 2023. Postoperative outcomes, including weight, were evaluated. Children with comorbidities affecting growth were excluded.Results: Thirty-eight children with severe laryngomalacia underwent supraglottoplasty, with 32 meeting the inclusion criteria; 59.4% were male. The mean age at diagnosis and surgery was 5.8 and 10.5 months, respectively. All cases of respiratory distress were resolved with surgery. In the weight evaluation, 18 patients (56.3%) had a preoperative percentile below 15, of whom ten were below the 5th percentile. A statistically significant increase was observed between preoperative percentile and consecutive postoperative percentiles at 1, 3 and 12 months. Regarding children with percentile below 15, 75% successfully crossed two percentile lines and 90% of children with failure to thrive managed to rise above the 5th percentile.Conclusions and significance: Supraglottoplasty leads to symptomatic improvement and a significant increase in weight percentile in patients with severe laryngomalacia. Growth curves adjusted for gender and age should be an objective measure of supraglottoplasty outcomes.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-4"},"PeriodicalIF":1.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental study on the application of irreversible electroporation/nanoknife on tonsil tissues in a rabbit model. 不可逆电穿孔/纳米刀在兔扁桃体组织模型上应用的实验研究。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-23 DOI: 10.1080/00016489.2025.2491652

Xinggang Tao, Jiayan Chen, Zhuo Li, Yihui Sun, Chunyu Shan, Yingfeng Li, Qian Li, Quanqin Hao, Ying Li, Xizhi Yang, Keyong Li

{"title":"Experimental study on the application of irreversible electroporation/nanoknife on tonsil tissues in a rabbit model.","authors":"Xinggang Tao, Jiayan Chen, Zhuo Li, Yihui Sun, Chunyu Shan, Yingfeng Li, Qian Li, Quanqin Hao, Ying Li, Xizhi Yang, Keyong Li","doi":"10.1080/00016489.2025.2491652","DOIUrl":"https://doi.org/10.1080/00016489.2025.2491652","url":null,"abstract":"Background: Irreversible electroporation (IRE)/nanoknife is a nonthermal technique for ablating solid tumors.Objectives: To investigate the application of IRE for ablating tonsil tissues in a rabbit model.Material and methods: Forty five rabbits were divided into three groups IRE, radiofrequency ablation (RFA) and control group. The IRE group received IRE in one or both tonsils, while the RFA group received IRE in one tonsil and RFA in the other. The control group had no operation. Rabbits were euthanized at days 1, 3, 7, 14, and 28 post-IRE ablation or RFA. White blood cell (WBC) counts, C-reactive protein (CRP), and creatine kinase (CK) levels were monitored and tonsil tissues were histologically examined.Results: IRE ablation induced cell apoptosis in tonsil tissues, which was most pronounced at 72 h post-treatment. At 14- and 28-days post-IRE ablation, lymphoid follicles regenerated in the tonsil tissues. The RFA group showed more severe injury and less tissue regeneration. Transient increases in WBC, CRP, and CK levels indicated inflammation and cardiac injury induced by IRE.Conclusions and significance: IRE is a potential modality for ablating tonsil tissues, which avoids thermal injury and preserving blood vessels. More robust studies with other animal models are required for definitive evidence.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes of the cough reflex sensitivity following the septoplasty. 鼻中隔成形术后咳嗽反射敏感性的变化。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-23 DOI: 10.1080/00016489.2025.2488483

Miroslava Lucanska, Vladimir Calkovsky, Marian Grendar, Martina Neuschlova, Marek Samec, Peter Kunc, Renata Pecova

{"title":"Changes of the cough reflex sensitivity following the septoplasty.","authors":"Miroslava Lucanska, Vladimir Calkovsky, Marian Grendar, Martina Neuschlova, Marek Samec, Peter Kunc, Renata Pecova","doi":"10.1080/00016489.2025.2488483","DOIUrl":"https://doi.org/10.1080/00016489.2025.2488483","url":null,"abstract":"Background: Doctors need information about cough reflex sensitivity influenced by symptomatic nasal septum deviation-the most common structural abnormality of the nasal cavity.Objectives: We assessed the relationship between cough reflex sensitivity and increased nasal patency caused by the deviation of nasal septum.Materials and methods: Eighteen adult patients (8 women and 10 men, age range 20-59 years, mean age 40.1 years) were included in the study. Capsaicin aerosol in doubling concentrations (from .49 to 1000 μmol/L) was inhaled by a single-breath method. We measured cough reflex sensitivity (C2, C5 values) before the septoplasty and 3 months after the septoplasty.Results: Patients cough reflex sensitivity before and after the septoplasty for C2 value was [21.25 (10.23-44.14) μmol/L vs. 57.85 (27.67-120.95) μmol/L] and for C5 value was [75.75 (31.56-181.80) μmol/l vs. 190.93 (109.46-333.02) μmol/L]. We have noticed statistically significant decrease of the cough reflex sensitivity after the septoplasty for both values (C2 and C5) (p = .001, p = .021).Conclusion and significance: Decreased nasal patency in patients after the septoplasty is related with decreased cough reflex sensitivity. Reduced cough reflex sensitivity after septoplasty is clinically significant, further research is needed to clarify the pathogenesis.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-3"},"PeriodicalIF":1.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does high PD-L1 expression reduce the risk of relapse after definitive surgery in patients with oral cavity cancer? 高PD-L1表达是否能降低口腔癌患者术后复发的风险？

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-23 DOI: 10.1080/00016489.2025.2489645

Parvin Babayev, Rashad Ismayilov, Oguz Kuscu, Arif Akyildiz, Olcay Kurtulan, Erim Pamuk, Yesim Gaye Guler Tezel, Ibrahim Halil Gullu

{"title":"Does high PD-L1 expression reduce the risk of relapse after definitive surgery in patients with oral cavity cancer?","authors":"Parvin Babayev, Rashad Ismayilov, Oguz Kuscu, Arif Akyildiz, Olcay Kurtulan, Erim Pamuk, Yesim Gaye Guler Tezel, Ibrahim Halil Gullu","doi":"10.1080/00016489.2025.2489645","DOIUrl":"https://doi.org/10.1080/00016489.2025.2489645","url":null,"abstract":"Background: Uncovering the molecular mechanisms of cancer pathogenesis is crucial for improving survival outcomes.Aims: This study investigates the impact of programmed death ligand 1 (PD-L1) expression on the risk of progression in patients with oral squamous cell carcinoma (OSCC).Materials and methods: The retrospective study included adult patients diagnosed with OSCC between January 2012 and December 2023. PD-L1 expression in tissue removed by definitive surgery was evaluated using immunohistochemistry, and tumor proportion score (TPS) and combined positive score (CPS) were calculated. Survival analyses were performed to assess its prognostic implications.Results: Among the 96 patients, TPS and CPS were 20% or above in 52 (54.2%) and 65 (67.7%) cases, respectively. TPS ≥20% was associated with mucosal lip location, earlier disease stage, and decreased risk of progression. The multivariate Cox regression model revealed that stage III/IV disease (HR: 2.176, 95%CI: 1.085-4.376, p = .029) and TPS ≥20% (HR: 0.241, 95%CI: 0.066-0.879, p = .031) were independent risk factors for progression-free survival.Conclusions: The study revealed that increased tumoral PD-L1 expression may reduce the risk of progression in patients with OSCC.Significance: These findings underscore the potential prognostic significance of PD-L1 expression in OSCC following surgical resection.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0