Acta Oto-Laryngologica最新文献_第3页

Examining the causal relationship between hypertension and benign paroxysmal vertigo: a univariate and multivariate Mendelian randomization study.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-23 DOI: 10.1080/00016489.2025.2479015

Luyao Wang, Feilun Cui, Xiangping Chen, Qing Zhang, Jun Yang, Shuna Li

{"title":"Examining the causal relationship between hypertension and benign paroxysmal vertigo: a univariate and multivariate Mendelian randomization study.","authors":"Luyao Wang, Feilun Cui, Xiangping Chen, Qing Zhang, Jun Yang, Shuna Li","doi":"10.1080/00016489.2025.2479015","DOIUrl":"https://doi.org/10.1080/00016489.2025.2479015","url":null,"abstract":"Background: Patients with benign paroxysmal positional vertigo (BPPV) may be at increased risk for hypertension.Objectives: To examine the causal relationship between hypertensive disorders and benign paroxysmal vertigo (BPV).Materials and methods: A bidirectional two-sample Mendelian randomization (MR) study was conducted to assess the causal relationship between hypertension and BPV. Summary statistics for BPV and hypertension were obtained from the FinnGen biobank to support the primary MR analysis. Five complementary methods - inverse variance weighted, weighted median, MR-Egger, simple mode, and weighted mode - were applied to obtain MR estimates. Furthermore, a multivariable MR (MVMR) analysis was conducted to examine whether hypertension independently influences BPV.Results: The MR analysis indicated a significant causal effect of hypertension on BPV, with an odds ratio (OR) of 1.11 (95% CI: 1.02-1.22, p = .019), indicating an increased risk of BPV associated with hypertension. MVMR analysis further indicated that the causal effect of hypertension on BPV remained significant even after adjusting for menopausal disorders and ischemic stroke (OR: 1.108, 95% CI: 1.003-1.225, p = .043).Conclusions and significance: This MR study provided evidence supporting a causal effect of hypertension on BPV.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of single versus multiple surgeries in CRSwNP patients undergoing treatment with dupilumab.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-23 DOI: 10.1080/00016489.2025.2481233

Matteo Alicandri-Ciufelli, Carla Cantaffa, Costanza Galloni, Ignazio Javier Fernandez, Daniele Marchioni, Carlotta Pipolo, Massimiliano Garzaro, Letizia Nitro, Valeria Dell'Era, Francesco Ferella, Massimo Campagnoli, Paolo Russo, Angelo Ghidini, Eugenio De Corso, Daniela Lucidi

{"title":"Impact of single versus multiple surgeries in CRSwNP patients undergoing treatment with dupilumab.","authors":"Matteo Alicandri-Ciufelli, Carla Cantaffa, Costanza Galloni, Ignazio Javier Fernandez, Daniele Marchioni, Carlotta Pipolo, Massimiliano Garzaro, Letizia Nitro, Valeria Dell'Era, Francesco Ferella, Massimo Campagnoli, Paolo Russo, Angelo Ghidini, Eugenio De Corso, Daniela Lucidi","doi":"10.1080/00016489.2025.2481233","DOIUrl":"https://doi.org/10.1080/00016489.2025.2481233","url":null,"abstract":"Background: Prior to the introduction of biologic drugs, the natural history of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) was characterized by multiple recurrences, thus necessitating multiple surgical interventions.Aims/objectives: To understand whether Dupilumab efficacy in recurrent CRSwNP varies based on number of previous surgeries.Materials and methods: This is a multicentric retrospective study on patients with CRSwNP under Dupilumab, who underwent at least one previous surgery. Correlations between number of previous surgeries and clinical outcomes at baseline and during treatment were investigated.Results: 141 patients were included. Mean number of prior surgeries was 2.19 (median 2; range 1-13). For all patients, significant improvements were observed across all time points. Poorer results were observed in patients subjected to more than one prior surgery in terms of NPS at T2 (p .04), SNOT-22 at T4 (p .03), VAS for olfactory dysfunction at T3 (p .01) and T5 (p .009), VAS for nasal obstruction at T4 (p .047), VAS for rhinorrhea at T4 (p .02), VAS for craniofacial pain at T1 (p .02) and T2 (p .04) and of VAS for sleep disturbances at T1 (p .04).Conclusions and significance: Patients subjected to multiple surgeries have worse outcomes during treatment with Dupilumab, particularly for what concerns craniofacial pain and olfactory dysfunction.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preservation of waves VI and VII of ABR in pediatric and adult patients with lesions in bilateral auditory cortices or radiations.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-14 DOI: 10.1080/00016489.2025.2475052

Ryohei Akiyoshi, Kimitaka Kaga

{"title":"Preservation of waves VI and VII of ABR in pediatric and adult patients with lesions in bilateral auditory cortices or radiations.","authors":"Ryohei Akiyoshi, Kimitaka Kaga","doi":"10.1080/00016489.2025.2475052","DOIUrl":"https://doi.org/10.1080/00016489.2025.2475052","url":null,"abstract":"Background: Auditory-evoked brainstem response (ABR) is widely used in various areas of clinical medicine. There is a common understanding regarding the origins of waves I to V in human ABR. However, little is known from where wave VI or VII originates in the central auditory pathway.Aims/objectives: The aim of our research is to elucidate the origins of waves VI and VII by studying ABR amplitude and latency and conducting magnetic resonance imaging (MRI).Materials and methods: Eleven patients diagnosed as having central auditory disorders participated in this study. They include five pediatric patients with herpes simplex infection and six adult patients with cerebrovascular events manifesting auditory agnosia or cortical deafness with lesions in the bilateral auditory cortices.Results: We found that waves VI and VII formed into one complex wave with biphasic peaks and the origin of these waves can be the medial geniculate body (MGB).Conclusions: On the basis of anatomical and electrophysiological findings, we suggest that the latency of VI-I or VII-I nerve conduction time is the auditory brainstem-thalamus transmission time.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minigene assay for verifying the splicing effects of the rare variants in the SLC12A2 gene at c.2930-1G>a.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-14 DOI: 10.1080/00016489.2025.2475486

Lin Mengsi, Zhu Qingwen, Cui Aimin, Wang Jing

{"title":"Minigene assay for verifying the splicing effects of the rare variants in the SLC12A2 gene at c.2930-1G>a.","authors":"Lin Mengsi, Zhu Qingwen, Cui Aimin, Wang Jing","doi":"10.1080/00016489.2025.2475486","DOIUrl":"10.1080/00016489.2025.2475486","url":null,"abstract":"Background: Hearing loss (HL) is a prevalent sensory impairment with a genetic basis. The SLC12A2 gene, encoding NKCC1, is vital for inner ear ion balance. The c.2930-1G > A variant is a novel mutation potentially linked to sensorineural hearing loss.Objectives: To investigate the splicing and protein expression effects of the c.2930-1G>A variant in SLC12A2 and its role in hearing loss.Material and methods: Minigene assays and plasmid transfection in HEK-293T and Hela cells were used to study splicing. Protein expression and modification were also assessed.Results: The c.2930-1G>A variant caused partial exon skipping, altering mRNA splicing in both cell types. This suggests a potential involvement in sensorineural hearing loss. Protein analysis showed the E21del mutation increased expression without altering modification patterns, whereas the 2930_2977del mutation reduced both, possibly impacting stability or modification sites.Conclusions and significance: The c.2930-1G>A variant likely contribute to hearing loss by disrupting splicing and protein expression. Currently a Variant of Uncertain Significance (VUS), its pathogenicity is supported by these findings. Further research is needed to confirm its role, emphasizing the need for integrated genetic and clinical data in auditory disorders management.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative outcome of palatine tonsillectomy by tonsil pillar suture with knot-free suture.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-13 DOI: 10.1080/00016489.2025.2476191

Yusei Yamaguchi, Shinya Ohira, Kota Wada

{"title":"Postoperative outcome of palatine tonsillectomy by tonsil pillar suture with knot-free suture.","authors":"Yusei Yamaguchi, Shinya Ohira, Kota Wada","doi":"10.1080/00016489.2025.2476191","DOIUrl":"https://doi.org/10.1080/00016489.2025.2476191","url":null,"abstract":"Background: Postoperative haemorrhage following palatine tonsillectomy occurs in 5-14% of cases. Since 2021, our department has used knot suturing with 3-0 Vicryl, and from 2023, continuous suturing with the V-Loc™ closure device to reduce suture time. While knot suturing is reported to reduce postoperative bleeding and pain, no studies have compared outcomes between different suture methods.Aims: This study retrospectively analysed postoperative bleeding, pain, and complications in 125 patients undergoing palatine tonsillectomy, with or without sutures.Methods: Patients aged ≥15 years who underwent bilateral tonsillectomy from October 2019 to March 2024 were grouped into no-suture, knot-suture, and knot-free-suture categories. Data on operative time, pain, bleeding, suture dissection, and complications were compared using the Mann-Whitney U test for continuous variables and the chi-square test for nominal variables.Results: Knot-free sutures had the shortest operative time (53 ± 16 min) compared to no sutures (62 ± 19 min) and knot sutures (94 ± 22 min). Pain decreased over time across all groups. Bleeding rates were similar, though knot-free sutures required frequent removal (76%). Knot sutures had a significantly lower dissection rate (<0.001).Conclusions and significance: Knot-free sutures improve surgical efficiency but may require additional postoperative interventions, representing a cost-effective alternative to high-energy devices.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allogeneic composite amniotic membrane in tympanic membrane repair: a randomized parallel controlled study.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-13 DOI: 10.1080/00016489.2025.2475487

Anchi Sun, Rongrong Lv, Zhiwei Xing, Xiaomin Wang, Mingjie Zhang, Mengjun Wang, Qianqian Shao, Hui Li

{"title":"Allogeneic composite amniotic membrane in tympanic membrane repair: a randomized parallel controlled study.","authors":"Anchi Sun, Rongrong Lv, Zhiwei Xing, Xiaomin Wang, Mingjie Zhang, Mengjun Wang, Qianqian Shao, Hui Li","doi":"10.1080/00016489.2025.2475487","DOIUrl":"https://doi.org/10.1080/00016489.2025.2475487","url":null,"abstract":"Backgrounds: Composite amniotic membranes have been widely used in ophthalmology and orthopedics. For the repair of tympanic membrane perforation, the introduction of amniotic membrane is still under study.Objectives: To analyse the effectiveness of a homograft composite amniotic membrane in tympanic membrane repair.Methods: A total of 76 patients were recruited and randomly assigned to the experimental group (n = 39) and the control group (n = 37). The test group employed a composite amniotic membrane for the repair of the tympanic membrane, while the control group utilized cartilage from the auricular for the same purpose. The efficacy of composite amniotic membrane was evaluated through a comparative analysis of postoperative tympanic membrane healing, complications, and hearing recovery.Results: Hearing improved significantly in both groups, but there was no significant difference between the two groups. The results of the postoperative pain scores demonstrated that the majority of patients were experiencing mild pain, with a notable discrepancy between the test group and the control group. Intraoperative bleeding time was also significantly lower in the test group than in the control group.Conclusion: Allogeneic composite amniotic membrane can be used as a material for repairing tympanic membrane perforation, which can effectively improve postoperative hearing of patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of functional and aesthetic outcomes following open technique septorhinoplasty: assessing the utility and correlation of the Rhinoplasty Health Inventory and Nasal Outcomes, Rhinoplasty Outcome Evaluation, and Nasal Obstructive Symptom Evaluation questionnaires.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-13 DOI: 10.1080/00016489.2025.2477210

Gamze Ozturk Yilmaz, Gokhan Yilmaz

{"title":"Evaluation of functional and aesthetic outcomes following open technique septorhinoplasty: assessing the utility and correlation of the Rhinoplasty Health Inventory and Nasal Outcomes, Rhinoplasty Outcome Evaluation, and Nasal Obstructive Symptom Evaluation questionnaires.","authors":"Gamze Ozturk Yilmaz, Gokhan Yilmaz","doi":"10.1080/00016489.2025.2477210","DOIUrl":"https://doi.org/10.1080/00016489.2025.2477210","url":null,"abstract":"Background: The importance of subjective quality of life questionnaires in evaluating post-rhinoplasty outcomes and patient satisfaction is increasing.Objective: This study aimed to measure the aesthetic and functional satisfaction of patients following septorhinoplasty using the Rhinoplasty Health Inventory and Nasal Outcomes (RHINO), Rhinoplasty Outcome Evaluation (ROE), and Nasal Obstructive Symptom Evaluation (NOSE) questionnaires.Methods: This prospective study included 306 patients who underwent a primary open-technique septorhinoplasty. The NOSE, ROE, and RHINO questionnaires were given to all patients before surgery and in the sixth month following surgery.Results: Preoperative NOSE, ROE, and RHINO scores significantly improved postoperatively in all patients (p < .001). Postoperative satisfaction was higher among young people, women, those with functional indications, single people, and those who were unemployed. Additionally, positive correlation existed between the RHINO and ROE scores (p < .001), and negative correlation existed between the postoperative RHINO and NOSE scores (p < .001).Conclusions: Thus, septorhinoplasty likely improves the functional and aesthetic quality of life in all patients. Our results suggest that a patient who scores favorable on the NOSE and ROE questionnaires is also likely to score favorable on the RHINO questionnaire.Significance: It is possible to evaluate septorhinoplasty results both functionally and aesthetically using just one questionnaire.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of nasal functions in Behçet's and neuro-Behçet's patients.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-01 DOI: 10.1080/00016489.2025.2470981

Sumeyye Gencer Culha, Mansur Dogan

{"title":"Evaluation of nasal functions in Behçet's and neuro-Behçet's patients.","authors":"Sumeyye Gencer Culha, Mansur Dogan","doi":"10.1080/00016489.2025.2470981","DOIUrl":"10.1080/00016489.2025.2470981","url":null,"abstract":"Background: Behçet's disease (BD) is a multisystemic inflammatory disease.Objectives: The aim of our study is to investigate whether BD and neuro-Behçet's disease (ND) cause any changes in nasal and olfactory functions.Materials and methods: Our study included 20 patients with BD (group BD), 17 patients with ND (group NB), and a control group of 20 healthy volunteers (group C). Participants underwent nasal endoscopic examination, peak nasal inspiratory flow (PNIF) test to assess nasal airway patency, saccharin test to measure mucociliary clearance and Sniffin' Sticks smell test to assess olfactory dysfunction.Results: In our study, when the groups were examined in terms of saccharin values, it was found to be statistically significantly longer in group BD and group NB (p < .001). In the odor discrimination test, a statistically significant difference was found only between group NB and group C. The odor identification test and total scores were found to be lower in group BD and group NB.Conclusions and significance: The results obtained in this study demonstrate that mucociliary activity and olfactory functions are significantly impaired in both the BD and NB groups.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of basic-fibroblast growth factor on tympanic membrane perforation in a mouse model of blast injury. 碱性成纤维细胞生长因子对爆炸伤小鼠模型鼓膜穿孔的影响

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-28 DOI: 10.1080/00016489.2025.2470971

Motohiro Sato, Kunio Mizutari, Takaomi Kurioka, Yoshiaki Inuzuka, Shingo Yasutake, Koji Araki, Yasushi Satoh, Akihiro Shiotani

{"title":"Effect of basic-fibroblast growth factor on tympanic membrane perforation in a mouse model of blast injury.","authors":"Motohiro Sato, Kunio Mizutari, Takaomi Kurioka, Yoshiaki Inuzuka, Shingo Yasutake, Koji Araki, Yasushi Satoh, Akihiro Shiotani","doi":"10.1080/00016489.2025.2470971","DOIUrl":"https://doi.org/10.1080/00016489.2025.2470971","url":null,"abstract":"Background: Tympanic membrane perforation (TMP) caused by blast injury result in poor TMP closure and pathological regeneration of the tympanic membrane (TM). TM regeneration therapy using basic fibroblast growth factor (bFGF) has demonstrated good outcomes for chronic otitis media.Aims/objectives: To investigate the efficacy of bFGF treatment in the management of blast-induced TMP.Material and methods: Male CBA/J mice (10-12-week-old) were divided into the bFGF-treatment and no-treatment groups. Blast-tube systems were used to induce TMP. Auditory evaluation, TM observation, histological evaluation of the regenerated TM, and histological evaluation of the inner ear were conducted.Results: Auditory assessment revealed no difference between the groups, with persistent auditory threshold elevation being observed even 1 month post-injury. Similarly, histological evaluation of the inner ear hair cells revealed no significant differences between the groups; no hair cell death was evident. However, the regenerated TM in the bFGF-treated group was significantly thicker than that in the untreated group.Conclusions and significance: A good TMP closure rate was observed in the present study; however, bFGF treatment exacerbated thickening of the regenerated TM. Future studies must study the therapeutic effects of bFGF treatment using various animal models and timing and concentration of bFGF treatment.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of polysomnography data and inflammatory markers after sleep surgery.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-27 DOI: 10.1080/00016489.2025.2470304

Öznur Gündüz, Şeyda Akbal Çufalı

{"title":"Correlation of polysomnography data and inflammatory markers after sleep surgery.","authors":"Öznur Gündüz, Şeyda Akbal Çufalı","doi":"10.1080/00016489.2025.2470304","DOIUrl":"https://doi.org/10.1080/00016489.2025.2470304","url":null,"abstract":"Background: The occurrence of hypoxia during apneas and hypopneas is associated with the triggering of an inflammatory response.Objectives: This study investigates the alterations in polysomnography (PSG) data, inflammatory markers, and the correlation between these alterations in patients undergoing sleep surgery.Methods: The data of 66 patients who underwent drug-induced sleep endoscopy followed by appropriate sleep surgery, with follow-up PSG performed at 3 to 6 months postoperatively, were retrospectively analyzed. Additionally, correlations with inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), eosinophil-to-lymphocyte ratio (ELR) and systemic immune-inflammation index (SII), were investigated.Results: Comparison of preoperative and postoperative inflammatory markers revealed statistically significant reductions in NLR, PLR, and SII (p < 0.001, p = 0.023, p = 0.026, respectively). Significant positive correlations were identified between AHI and NLR (p = 0.001, r = 0.400), PLR (p = 0.001, r = 0.415) and SII (p = 0.010, r = 0.392). Similarly, a significant positive correlation was observed between supine AHI and NLR (p = 0.035, r = 0.379), PLR (p = 0.008, r = 0.325), and SII (p = 0.030, r = 0.367). The time spent with SaO2 below 90% was found to be significantly and positively correlated with NLR (p = 0.023, r = 0.279), PLR (p = 0.027, r = 0.272), and SII (p = 0.033, r = 0.256).Conclusions and significance: A correlation was observed between the postoperative decrease in SII, NLR, and PLR values and PSG data in patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0