Acta Oto-Laryngologica最新文献_第3页

Testing for genetic and viral etiologies in congenital hearing loss based on a survey of cochlear implant centers: proposed HEARRING group consensus and future directions. 基于人工耳蜗植入中心调查的先天性听力损失基因和病毒病因测试：HEARRING 小组的共识建议和未来方向。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-10-25 DOI: 10.1080/00016489.2024.2414803

Shin-Ichi Usami, Shin-Ya Nishio, Javier Gavilán, Aanand Acharya, Abdulrahman Hagr, Luis Lassaletta, Yongxin Li, S Sudha Maheshwari, Mohan Kameswaran, Thomas Parzefall, Chris Raine, Kristen Rak, Anne Morgan Selleck, Hinrich Staecker, Timo Stöver, Serafima Sugarova, Vedat Topsakal, Vincent Van Rompaey, Griet Mertens, Stefan Volkenstein, Christiane Völter, Wafaa Shehata-Dieler, Mario E Zernotti, Paul Van de Heyning

{"title":"Testing for genetic and viral etiologies in congenital hearing loss based on a survey of cochlear implant centers: proposed HEARRING group consensus and future directions.","authors":"Shin-Ichi Usami, Shin-Ya Nishio, Javier Gavilán, Aanand Acharya, Abdulrahman Hagr, Luis Lassaletta, Yongxin Li, S Sudha Maheshwari, Mohan Kameswaran, Thomas Parzefall, Chris Raine, Kristen Rak, Anne Morgan Selleck, Hinrich Staecker, Timo Stöver, Serafima Sugarova, Vedat Topsakal, Vincent Van Rompaey, Griet Mertens, Stefan Volkenstein, Christiane Völter, Wafaa Shehata-Dieler, Mario E Zernotti, Paul Van de Heyning","doi":"10.1080/00016489.2024.2414803","DOIUrl":"10.1080/00016489.2024.2414803","url":null,"abstract":"Background: In cases of congenital sensorineural hearing loss, testing for genetic etiologies and congenital cytomegalovirus (cCMV) infection have become common practice.Aims/objectives: The purpose of this study is to determine which specific testing methodologies should be used and when.Material and methods: We surveyed 20 practicing otolaryngologists across eighteen institutions in thirteen countries about their approach to cCMV, GJB2, and wider genetic testing.Results: We found 90% of respondents employ all three tests, either in routine or special cases. cCMV testing is widely used, with 95% of respondents incorporating it into their clinical practice. GJB2 testing was employed by 90%. In cases with negative GJB2 test results, a majority of respondents proceeded to wider genetic screening. Test reimbursement was also examined for each test. For cCMV testing, 63.1% reported reimbursement, 68.4% reported reimbursement for GJB2 variant testing and 52.6% reported reimbursement for wider genetic screening.Conclusions and significance: A common approach is to perform cCMV and GJB2 testing as the first tests, followed by wider genetic testing. This study offers insight into the prevalence, methodologies, and reimbursement status of these testing methodologies across multiple hearing centers and countries. Current consensus and future directions are described based on the current survey.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"602-609"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hearing and balance functions in adults with ıron deficiency. 患有ı铁缺乏症的成年人的听力和平衡功能。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-11-27 DOI: 10.1080/00016489.2024.2428260

Serpil Demir, Alper Köycü, Selim S Erbek

{"title":"Hearing and balance functions in adults with ıron deficiency.","authors":"Serpil Demir, Alper Köycü, Selim S Erbek","doi":"10.1080/00016489.2024.2428260","DOIUrl":"10.1080/00016489.2024.2428260","url":null,"abstract":"Background: Because the inner ear requires high-energy metabolism and because of the iron content of some cochlear enzymes, iron deficiency-related hypoxia can affect hearing and the balance system.Objectives: To evaluate the hearing and balance functions in adults with iron deficiency (ID) and iron deficiency anemia (IDA).Material and methods: 22 ID patients, 22 IDA patients and 22 healthy controls underwent pure tone audiometry (0.125-16 kHz), VNG, VEMP, and vHIT.Results: Significant differences were observed in the hearing thresholds of the IDA group at frequencies ranging from 0.125 kHz to 14 kHz, as well as in the ID group at frequencies of 2.0 kHz, 4.0 kHz, and 6.0 kHz. The pursuit test was pathological at the rate of 40.9% in the IDA group. The oVEMP test showed prolonged latency values in both ID and IDA groups. IDA group had lower p1-n1 amplitude than the control group in the oVEMP and cVEMP tests. A significant difference was determined between the groups concerning anterior SCC VOR gains.Conclusions and significance: The hypoxia caused by anemia might negatively impact hearing and vestibular functions. The current study is the first study to comprehensively evaluate anemia patients with VNG, VEMP, and vHIT tests.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"620-626"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of influencing factors of residual dizziness after repositioning of horizontal semicircular canal benign paroxysmal positional vertigo. 水平半规管良性阵发性位置性眩晕复位后残余眩晕的影响因素分析。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-11-02 DOI: 10.1080/00016489.2024.2416079

Bingtong Lin, Yuan Liu, Dezhi Deng, Genquan Huang, Juan Qu, Junjie Xu, Jin Hu, Baoxiang Wang

{"title":"Analysis of influencing factors of residual dizziness after repositioning of horizontal semicircular canal benign paroxysmal positional vertigo.","authors":"Bingtong Lin, Yuan Liu, Dezhi Deng, Genquan Huang, Juan Qu, Junjie Xu, Jin Hu, Baoxiang Wang","doi":"10.1080/00016489.2024.2416079","DOIUrl":"10.1080/00016489.2024.2416079","url":null,"abstract":"Background: Horizontal semicircular canal benign paroxysmal positional vertigo(HSC-BPPV) is the second most common type of BPPV. It is difficult to diagnose and treat, which has a serious impact on the prognosis of patients.Objectives: To study the clinical features of HSC-BPPV and the influencing factors of residual dizziness (RD).Materials and methods: The clinical data of 358 patients with BPPV were retrospectively collected. The differences between HSC-BPPV and posterior semicircular canal benign paroxysmal positional vertigo (PSC-BPPV) were compared, and the influencing factors of RD after HSC-BPPV repositioning were analyzed.Results: ① Compared with PSC-BPPV, HSC-BPPV had a lower success rate of first repositioning (64.7 vs. 75.0%), a higher incidence of RD (57.3 vs. 43.8%), and a higher DHI score (40.0 vs. 34.0), and the differences were statistically significant (p < .05). ② Logistic regression analysis showed that age ≥60 years, secondary, DHI score, successful first repositioning were the influencing factors for the development of RD after HSC-BPPV repositioning (p < .05).Conclusions and significance: The diagnosis and treatment of HSC-BPPV is difficult, and RD is prone to occur. Clinicians need to strengthen the training of HSC-BPPV diagnosis and treatment to reduce the occurrence and progression of RD.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"610-614"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case-control study of otoconia proteins otolin-1 and otoconin-90 in patients with Meniere's disease. 梅尼埃病患者耳声蛋白 otolin-1 和 otoconin-90 的病例对照研究。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-11-09 DOI: 10.1080/00016489.2024.2423661

Weiwei Han, Qinfeng Wu, Yunqin Wu, Xiaoxiong Lu, Lulu Li, Kewang Zhou, Weinv Fan

{"title":"Case-control study of otoconia proteins otolin-1 and otoconin-90 in patients with Meniere's disease.","authors":"Weiwei Han, Qinfeng Wu, Yunqin Wu, Xiaoxiong Lu, Lulu Li, Kewang Zhou, Weinv Fan","doi":"10.1080/00016489.2024.2423661","DOIUrl":"10.1080/00016489.2024.2423661","url":null,"abstract":"Backgrounds: Otolin-1 and otoconin-90, the main otoconia matrix protein, can pass through the labyrinth-blood barrier and are detectable in the peripheral blood. Previous studies have shown that serum levels of these proteins well reflect otolith status, but none of concerning Meniere's disease (MD).Objectives: This study aimed to evaluate the serum levels of otolin-1 and otoconin-90 in patients with MD.Material and methods: Patients with MD confirmed during an acute episode, and age- and sex-matched controls were recruited. Their demographic and clinical data were recorded. The serum levels of otolin-1 and otoconin-90 were measured and compared.Results: A total of 33 patients with MD and 176 healthy controls were recruited. In patients with MD, the median otolin-1 level was 284.96 pg/mL (interquartile range [IQR] 208.65-331.49 pg/mL) and the median otoconin-90 level was 60.50 ng/mL (IQR 40.61-85.62 ng/mL), which were significantly higher than those in the control group (p < 0.0001 and p = 0.005, respectively). Among patients with MD, serum otoconin-90 levels were correlated with the MD clinical grade (ρ = 0.487, p = 0.04), whereas serum otoconin-1 levels were not (ρ = 0.327, p = 0.063).Conclusions: Serum levels of otolin-1 and otoconin-90 may serve as biomarkers of otolith lesions in patients with MD.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"588-591"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma knife sphenopalatine artery cauterization via lateral nasal wall incision for posterior epistaxis. 等离子刀通过鼻外侧壁切口烧灼治疗后鼻衄。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-10-28 DOI: 10.1080/00016489.2024.2416598

Ning Zhou, Dan Su, Junjie Ma

{"title":"Plasma knife sphenopalatine artery cauterization via lateral nasal wall incision for posterior epistaxis.","authors":"Ning Zhou, Dan Su, Junjie Ma","doi":"10.1080/00016489.2024.2416598","DOIUrl":"10.1080/00016489.2024.2416598","url":null,"abstract":"Background: Endoscopic sphenopalatine artery cauterization (ESPAC) has become an important method to manage posterior epistaxis.Aims/objectives: To investigate the application of plasma knife and lateral nasal wall incision in ESPAC in the treatment of posterior epistaxis.Material and methods: A retrospective study of 32 cases who underwent ESPAC for epistaxis was conducted. A vertical incision was made on the lateral nasal well to expose the sphenopalatine artery (SPA). The main branches of SPA were cauterized with a plasma knife or bipolar coagulation forceps. Cases were divided into plasma knife group (group PK) and bipolar group (group BP). The re-bleeding rates, operation time and the incidence of serious complication were compared between the two groups.Results: ESPAC was successfully completed via a lateral nasal wall incision without maxillary antrostomy in all cases. All the patients were followed-up for 3 months, no serious complication was reported. There was no significant difference in re-bleeding rates and incidence of serious complication between the two groups. The operation time of group PK was shorter than group BP.Conclusions and significance: Lateral nasal well incision without maxillary antrostomy is feasible for ESPAC. The application of a plasma knife may help to shorten the operation time.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"627-630"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved intracochlear biopolymeric drug delivery system: an in vivo study. 改进的蜗内生物聚合物给药系统：体内研究。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-11-10 DOI: 10.1080/00016489.2024.2412719

Stefania Goncalves, Torin Thielhelm, Devon Pawley, Esperanza Bas, Emre Dikici, Sapna K Deo, Christine T Dinh, Sylvia Daunert, Fred Telischi

{"title":"Improved intracochlear biopolymeric drug delivery system: an in vivo study.","authors":"Stefania Goncalves, Torin Thielhelm, Devon Pawley, Esperanza Bas, Emre Dikici, Sapna K Deo, Christine T Dinh, Sylvia Daunert, Fred Telischi","doi":"10.1080/00016489.2024.2412719","DOIUrl":"10.1080/00016489.2024.2412719","url":null,"abstract":"Background: The delivery of drugs into the inner ear is a challenging field of study due to the complex cochlear anatomy and physiology. The creation of an intracochlear device that allows for short- and long-term intracochlear delivery of the drugs with a minimal invasive technology is needed to prevent or treat conditions that can potentially prevent the development of permanent hearing loss.Aim: This study intends to test the efficacy of DXM-infused PLGA microneedles created in our laboratory in an in vivo animal model of acute ototoxic injury.Material and methods: Twenty-four male Norway Brown rats were randomized into four groups, three of which groups received an intratympanic injection of ethacrynic acid and kanamycin. Two of these groups underwent the placement of an intracochlear microneedle blended or not with dexamethasone, and two groups underwent implantation of a plain microneedle, one of without prior exposure to the ototoxic agent to confirm in vivo biocompatibility. Animals were then followed with a weekly auditory brainstem response testing until day 28 after surgical intervention.Result and conclusion: Our intracochlear device demonstrated biocompatibility and produced no hearing changes after its implantation in the control group. Inserted DXM-blended microneedles prevented hearing deterioration in those animals exposed to an ototoxic environment.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"581-587"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Narrow band imaging in oral cancer did not improve visualisation of the tumour borders: a prospective cohort study. 口腔癌窄带成像并不能改善肿瘤边界的可视化：一项前瞻性队列研究。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-11-12 DOI: 10.1080/00016489.2024.2418334

Olof Nilsson, Mathias von Beckerath, Johan Knutsson, Fredrik J Landström

{"title":"Narrow band imaging in oral cancer did not improve visualisation of the tumour borders: a prospective cohort study.","authors":"Olof Nilsson, Mathias von Beckerath, Johan Knutsson, Fredrik J Landström","doi":"10.1080/00016489.2024.2418334","DOIUrl":"10.1080/00016489.2024.2418334","url":null,"abstract":"Background: In oral cancers, tumour borders are typically defined by white light (WL). Narrow-band imaging (NBI) is an optical endoscopic technique commonly used for the larynx and for cancers of unknown primary. However, evidence for using NBI in oral cancers is insufficient.Aims/objectives: We investigated whether NBI is a better predictor of the true mucosal tumour borders than WL in oral cancers. Additionally, we examined the agreement between NBI-based Takano intrapapillary capillary loop classifications and pathology reports.Materials and methods: In this prospective study, the tumour borders were assessed by both NBI and WL at the time of surgical resection and then compared. Pathology reports of the examined areas were used as gold standard.Results: Forty-nine participants were included. After exclusion of 15 patients due to missing data, 34 were included in analyses. In 26.5% of the assessments, the tumour borders defined by NBI were outside the borders defined by WL. However, 55.5% of these were false-positives.Conclusions and significance: The delineation of mucosal tumour borders in oral cancers by NBI was not better than that by WL in this study. Several methodological challenges may have influenced the findings of this study, similar to the limitations reported in previous studies.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"652-656"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes of extracapsular tonsillectomy in the treatment of obstructive sleep apnoea in adults. 囊外扁桃体切除术治疗成人阻塞性睡眠呼吸暂停的长期疗效。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 DOI: 10.1080/00016489.2024.2420700

Jenny Knubb, Henrik M Sjöblom, Ella Ikonen, Miika Suomela, Jaakko M Piitulainen

{"title":"Long-term outcomes of extracapsular tonsillectomy in the treatment of obstructive sleep apnoea in adults.","authors":"Jenny Knubb, Henrik M Sjöblom, Ella Ikonen, Miika Suomela, Jaakko M Piitulainen","doi":"10.1080/00016489.2024.2420700","DOIUrl":"10.1080/00016489.2024.2420700","url":null,"abstract":"Background: Tonsillectomy is an effective treatment option for obstructive sleep apnoea in selected adult patients, but there has been a lack of long-term follow-up data.Objectives: To analyse the long-term outcomes of extracapsular tonsillectomy in the treatment of obstructive sleep apnoea in adults, with the longest follow-up periods to date.Materials and methods: We recruited adults who had undergone extracapsular tonsillectomy because of obstructive sleep apnoea between 2004 and 2018 in the Hospital District of Southwest Finland. A new home sleep study, questionnaires, and a structured phone interview were conducted on these patients 4-17 years after surgical treatment. The primary outcome was the change in the apnoea-hypopnoea index.Results: The mean apnoea-hypopnoea index was reduced from 27.1 preoperatively to 14.1 after the long-term follow-up (mean 12 years), and the mean Epworth Sleepiness Scale score decreased from 9.2 to 4.6. The long-term surgical success rate was 38.5%. Four out of five patients would choose the surgery again according to the phone interview.Conclusions and significance: This study supports the notion that extracapsular tonsillectomy alone can be considered as a surgical treatment option for selected adults with obstructive sleep apnoea and tonsillar hypertrophy. For most of the patients, the obstructive sleep apnoea is alleviated.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"646-651"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ototoxicity associated with hematopoietic stem cell transplantation; what are the risk factors? 与造血干细胞移植相关的耳毒性；有哪些风险因素？

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-10-29 DOI: 10.1080/00016489.2024.2411350

Eray Uzunoğlu, Muhittin Akalın, Zübeyde Nur Özkurt, Zeynep Arzu Yegin, Recep Karamert

{"title":"Ototoxicity associated with hematopoietic stem cell transplantation; what are the risk factors?","authors":"Eray Uzunoğlu, Muhittin Akalın, Zübeyde Nur Özkurt, Zeynep Arzu Yegin, Recep Karamert","doi":"10.1080/00016489.2024.2411350","DOIUrl":"10.1080/00016489.2024.2411350","url":null,"abstract":"Background: Hematopoietic stem cell transplantation (HSCT) is a critical treatment for various hematologic malignancies but can lead to complications, including ototoxicity.Aim/objectives: This study aims to explore the relationship between patient-specific factors and ototoxicity in adult HSCT patients.Material and methods: We conducted a retrospective analysis of 129 adult patients who underwent HSCT between 2003 and 2020. Age, gender, transplant indications, conditioning regimens, and pre- and post-transplant audiometry thresholds data were collected from patient files. A hearing loss of 10 decibels or more at two consecutive frequencies or a hearing loss of 20 decibels or more at a single frequency was considered as significant hearing loss (SHL). Statistical analyses were performed to describe factors associated with SHL.Results: SHL occurred in 16.3% of patients. Older age was significantly associated with an increased risk of SHL (p = .035). Poorer pretransplant hearing thresholds at 4000 Hz and 6000 Hz were also significant predictors of SHL (p = .039 and p = .014, respectively). There was no significant relationship between the donor type of HSCT (autologous vs. allogeneic) and ototoxicity (p = .45), and between conditioning regimens and ototoxicity (p = .860).Conclusions: Age and pre-existing hearing levels are significant predictors of ototoxicity post-HSCT. Careful management and monitoring are essential to prevent and address hearing loss in HSCT patients to improve hearing-related quality of life.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"615-619"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Actinomyces status and inflammatory biomarkers in post-tonsillectomy hemorrhage cases. 扁桃体切除术后出血病例中的放线菌状态和炎症生物标志物。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-10-26 DOI: 10.1080/00016489.2024.2410330

Burak Hazır, Zeliha Berfu Kastal, Eray Uzunoğlu

{"title":"Actinomyces status and inflammatory biomarkers in post-tonsillectomy hemorrhage cases.","authors":"Burak Hazır, Zeliha Berfu Kastal, Eray Uzunoğlu","doi":"10.1080/00016489.2024.2410330","DOIUrl":"10.1080/00016489.2024.2410330","url":null,"abstract":"Background: The presence of Actinomyces can be associated with complications.Aims: This study aimed to determine the frequency of post-tonsillectomy hemorrhage (PTH), the presence of Actinomyces in palatine tonsils and serum inflammatory biomarker levels in PTH.Material and methods: The cases who underwent tonsillectomy at a single center were included in the study. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) values were calculated from the complete blood count test. The presence of Actinomyces was recorded from histopathological tonsillectomy material.Results: A total of 1137 patients were included in the study. Actinomyces was detected in 93 (8.18%) patients. Bleeding complications were encountered in 65 cases (5.72%). No relationship was detected between the presence of Actinomyces and PTH rates (p = 0.433). While a relationship was found between age, NLR, and SIRI values and Actinomyces status (respectively, p < 0.001, p = 0.017, p = 0.038), no statistically significant relationship was found between tonsil size, PLR, and SII (p > 0.05).Conclusion and significance: According to the data in our study, NLR and SIRI values were elevated in subjects with Actinomyces. Our findings suggest that this entity has a systemic manifestation. Serum inflammatory biomarkers and the presence of Actinomyces were not found to be associated with PTH.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"641-645"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0