Acta Oto-LaryngologicaPub Date : 2025-04-01Epub Date: 2025-02-03DOI: 10.1080/00016489.2025.2459343
Hye Ah Joo, Byung Chul Kang, Tae Su Kim, Woo Seok Kang, Hong Ju Park, Jong Woo Chung, Joong Ho Ahn
{"title":"A trend of otologic diseases during the coronavirus disease 2019 pandemic period.","authors":"Hye Ah Joo, Byung Chul Kang, Tae Su Kim, Woo Seok Kang, Hong Ju Park, Jong Woo Chung, Joong Ho Ahn","doi":"10.1080/00016489.2025.2459343","DOIUrl":"10.1080/00016489.2025.2459343","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19) changed the practice of medicine, and various anti-contagion restrictions were implemented worldwide.</p><p><strong>Objectives: </strong>This study aimed to evaluate the annual trend in the incidence of otologic diseases during the COVID-19 pandemic and determine the influence of social restrictions on these diseases.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed the number of patients treated for otologic diseases, particularly those associated with infectious pathophysiology, and the total number of patients in the otolaryngology departments at three tertiary referral centers in South Korea.</p><p><strong>Results: </strong>The number of patients who underwent ventilation tube insertion due to persistent otitis media with effusion (OME) significantly decreased (raw number: -37.1%, incidence: -2.04‰) after the onset of the COVID-19 pandemic. However, a sharp increase was observed in 2023 (raw number: +42.9%, incidence: +1.63‰) when the pandemic officially ended. The number of patients newly diagnosed with sudden sensorineural hearing loss (SSNHL) gradually increased during the pandemic period.</p><p><strong>Conclusions and significance: </strong>Restrictive measures to control COVID-19 spread positively influenced the reduction in the incidence of OME. Whether COVID-19 is a direct risk factor for SSNHL remains uncertain, but the potential impact of the virus itself or the COVID-19 vaccine on the auditory system appears to exist.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"277-282"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Oto-LaryngologicaPub Date : 2025-04-01Epub Date: 2025-02-10DOI: 10.1080/00016489.2025.2461653
Linda Nissi, Teemu Huusko, Johannes Routila, Samuli Vaittinen, Ilmo Leivo, Heikki Irjala, Sami Ventelä
{"title":"Added value of HPV-DNA <i>in situ</i> hybridization as an adjunct to p16 Immunohistochemistry in oropharyngeal squamous cell carcinoma.","authors":"Linda Nissi, Teemu Huusko, Johannes Routila, Samuli Vaittinen, Ilmo Leivo, Heikki Irjala, Sami Ventelä","doi":"10.1080/00016489.2025.2461653","DOIUrl":"10.1080/00016489.2025.2461653","url":null,"abstract":"<p><strong>Background: </strong>Current guidelines recommend p16 immunohistochemistry (IHC) for testing human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OPSCC). The need for additional HPV-DNA testing is debated.</p><p><strong>Aims/objectives: </strong>We evaluated the prognostic value of HPV-DNA <i>in situ</i> hybridization (ISH) as an adjunct to p16.</p><p><strong>Material and methods: </strong>A population-based cohort of 1,033 head and neck squamous cell carcinoma patients was used, to identify 124 OPSCC patients treated with a curative intent.</p><p><strong>Results: </strong>Of the p16-positive patients, 17.9% did not show evidence for presence of HPV-DNA in ISH. Both p16 and HPV-DNA ISH were significant prognostic factors for overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS) when used independently. When combining information from p16 IHC and HPV-DNA ISH, survival of the p16+/ISH- discordant patients was intermediate compared to the p16+/ISH+ and p16-/ISH- groups. In the discordant group, smoking was a strong prognostic determinator, with non-smokers having an outstanding prognosis.</p><p><strong>Conclusions and significance: </strong>Both p16 IHC and HPV-DNA ISH perform well as separate prognostic biomarkers for OS, DSS, and DFS on a population level. However, a discordant group does exist. Limiting HPV-DNA testing for p16-positive patients who smoke by the time of diagnosis may be a cost-efficient and justified solution.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"340-347"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ai Wang, Qingfeng Li, Hongwei Zheng, Lin Han, Jinmei Xue, Lisheng Yu
{"title":"Evaluation of surgical intervention for chronic suppurative otitis media in patients with hematologic diseases.","authors":"Ai Wang, Qingfeng Li, Hongwei Zheng, Lin Han, Jinmei Xue, Lisheng Yu","doi":"10.1080/00016489.2025.2471940","DOIUrl":"https://doi.org/10.1080/00016489.2025.2471940","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness and safety of surgical treatment for chronic suppurative otitis media (CSOM) in patients with hematologic diseases.</p><p><strong>Methods: </strong>This retrospective study included 26 patients (16 males and 10 females; median age of 36.5 years) with CSOM and hematological diseases treated over three years. All patients received chemotherapy before surgery. Preoperative symptoms included hearing loss accompanied by intermittent ear discharge, ear pain, and dizziness, but no facial paralysis. Surgical indications were recurrent infections, invasive fungal otitis during chemotherapy, or planned hematopoietic stem cell transplantation. Based on the extent of the lesions and intraoperative conditions.</p><p><strong>Results: </strong>All surgeries were successful with a median duration of 70.5 (36-120) minutes and intraoperative blood loss of < 20 mL, without postoperative complications. Hospital stay averaged 9 (8-15) days. During the 6-24-month follow-up, one patient experienced a recurrence of CSOM, and one died from worsening hematologic disease. The remaining patients recovered well and continued to receive appropriate hematologic treatment.</p><p><strong>Conclusions: </strong>Surgical treatment is a safe and effective option for patients with CSOM and hematologic diseases. It can improve patient outcomes and facilitate ongoing and subsequent hematologic cure.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Audiological findings in patients with leprosy.","authors":"Mahmut Uzut, Senem Erdur Uzut, Fatma Tülin Kayhan, Levent Küfeciler, Zübeyde Elmalı","doi":"10.1080/00016489.2025.2482170","DOIUrl":"10.1080/00016489.2025.2482170","url":null,"abstract":"<p><strong>Background: </strong>Leprosy, caused by <i>Mycobacterium leprae</i>, is a chronic infectious disease primarily affecting the skin and nervous system. The vestibulocochlear nerve may also be impacted, potentially leading to auditory dysfunction.</p><p><strong>Aims/objectives: </strong>This study investigates the effects of leprosy on the vestibulocochlear nerve and its impact on auditory function through a comprehensive audiological evaluation.</p><p><strong>Material and methods: </strong>A total of 15 leprosy patients and 15 healthy individuals were included. Audiological assessments were conducted at a tertiary care hospital. All participants underwent pure-tone audiometry, speech audiometry, tympanometry, acoustic reflex testing, otoacoustic emissions (OAE), and brainstem auditory evoked response (BERA) tests. Hearing thresholds, wave latencies, and neural conduction were analyzed.</p><p><strong>Results: </strong>Hearing thresholds were significantly higher in leprosy patients than in the control group. BERA results showed a significant prolongation of wave I and wave III latencies in leprosy patients, indicating dysfunction at the level of the acoustic nerve and superior olivary complex.</p><p><strong>Conclusions and significance: </strong>Leprosy may contribute to auditory dysfunction by affecting the myelin sheath of the peripheral and central nervous systems. These findings provide insight into the impact of leprosy on the vestibulocochlear nerve and emphasize the importance of audiological evaluation in leprosy patients.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karin Hallin, Nadine Schart-Morén, Helge Rask-Andersen
{"title":"Speech perception and hearing preservation after cochlear implantation in patients with Meniere's disease.","authors":"Karin Hallin, Nadine Schart-Morén, Helge Rask-Andersen","doi":"10.1080/00016489.2025.2481501","DOIUrl":"https://doi.org/10.1080/00016489.2025.2481501","url":null,"abstract":"<p><strong>Introduction: </strong>Cochlear implantation can be used as a treatment for severe sensorineural hearing loss in patients with Meniere's disease.</p><p><strong>Aim: </strong>The aim of the present study was to investigate speech perception and the grade of hearing preservation in patients diagnosed with Meniere's disease. One additional aim was to investigate the effects of cochlear implant surgery on balance and tinnitus.</p><p><strong>Methods: </strong>Adult patients with a known diagnosis of Meniere's disease were evaluated. Their speech perception and the degree of hearing preservation were compared with adult patients with sensorineural hearing loss of different etiologies. For the patients with Meniere's disease, their subjective reports on balance and tinnitus pre- and post-surgery were also investigated.</p><p><strong>Results: </strong>Both groups showed a statistically significant improvement in speech perception after cochlear implantation (<i>p</i> < .05); no statistically significant difference was found between the two groups. Analysis of hearing preservation for the two groups showed no statistically significant difference. Tinnitus decreased in 44.4% of the Meniere's disease patients one year post surgery.</p><p><strong>Conclusion: </strong>We found no difference in speech perception with cochlear implant in patients with Meniere's disease compared with patients with other etiologies, and there was no difference in the rate of hearing preservation. Tinnitus improved after cochlear implant treatment in patients with Meniere's disease.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The 133-kDa N-terminal region of myosin XVa is critical for normal structure and function of auditory and hair cells.","authors":"Yong Li, Yanli Wang, Jiong Dang, Wenjing Zhuo, Baicheng Xu, Yufen Guo","doi":"10.1080/00016489.2025.2479632","DOIUrl":"https://doi.org/10.1080/00016489.2025.2479632","url":null,"abstract":"<p><strong>Background: </strong><i>MYO15A</i> is a commonly implicated gene in severe to profound sensorineural hearing loss. Numerous studies have identified mutations in <i>MYO15A</i> in humans, analyzed their presence and co-segregation, and predicted their pathogenicity using software tools. However, few have investigated the pathogenic mechanisms of these mutations using mouse models. In a prior study, we identified the <i>MYO15A</i> c.2482 C > T mutation as a potential causative gene for deafness in a Uygur family from Xinjiang. To further explore the pathogenicity and mechanisms of this mutation, we constructed a mouse model harboring the <i>Myo15a</i> c.2455A > T mutation. This study demonstrates that mice with the <i>Myo15a</i> c.2455A > T spot knock-in exhibit the abnormal hair cell morphology, dysfunction, and hearing loss phenotype observed in humans.</p><p><strong>Objectives: </strong>To investigate the pathogenic mechanism of deafness caused by <i>MYO15A</i> c.2482C > T mutation.</p><p><strong>Material and methods: </strong>To assess the impact of the MYO15A mutation on hair cell morphology and function, mice underwent audiological tests, quantitative real-time PCR, scanning electron microscopy, immunofluorescence, and Western blot analysis.</p><p><strong>Results: </strong>The p.Arg819* mutation located in the N-terminal domain of <i>MYO15A</i> showed marked differences in hair cell morphology and function between homozygous mutant mice and normal controls. Notably, the homozygous mutant mice retained residual hearing up to approximately five weeks of age.</p><p><strong>Conclusions and significance: </strong>Our findings confirm that <i>Myo15a</i> c.2455A > T spot knock-in mice replicate the abnormal hair cell morphology and dysfunction, as well as the hearing loss phenotype. Additionally, our results indicate that the novel c.2482C > T variant in the <i>MYO15A</i> gene can cause inner ear hair cell dysfunction and audiological disorders in this family.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-12"},"PeriodicalIF":1.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luyao Wang, Feilun Cui, Xiangping Chen, Qing Zhang, Jun Yang, Shuna Li
{"title":"Examining the causal relationship between hypertension and benign paroxysmal vertigo: a univariate and multivariate Mendelian randomization study.","authors":"Luyao Wang, Feilun Cui, Xiangping Chen, Qing Zhang, Jun Yang, Shuna Li","doi":"10.1080/00016489.2025.2479015","DOIUrl":"https://doi.org/10.1080/00016489.2025.2479015","url":null,"abstract":"<p><strong>Background: </strong>Patients with benign paroxysmal positional vertigo (BPPV) may be at increased risk for hypertension.</p><p><strong>Objectives: </strong>To examine the causal relationship between hypertensive disorders and benign paroxysmal vertigo (BPV).</p><p><strong>Materials and methods: </strong>A bidirectional two-sample Mendelian randomization (MR) study was conducted to assess the causal relationship between hypertension and BPV. Summary statistics for BPV and hypertension were obtained from the FinnGen biobank to support the primary MR analysis. Five complementary methods - inverse variance weighted, weighted median, MR-Egger, simple mode, and weighted mode - were applied to obtain MR estimates. Furthermore, a multivariable MR (MVMR) analysis was conducted to examine whether hypertension independently influences BPV.</p><p><strong>Results: </strong>The MR analysis indicated a significant causal effect of hypertension on BPV, with an odds ratio (OR) of 1.11 (95% CI: 1.02-1.22, <i>p</i> = .019), indicating an increased risk of BPV associated with hypertension. MVMR analysis further indicated that the causal effect of hypertension on BPV remained significant even after adjusting for menopausal disorders and ischemic stroke (OR: 1.108, 95% CI: 1.003-1.225, <i>p</i> = .043).</p><p><strong>Conclusions and significance: </strong>This MR study provided evidence supporting a causal effect of hypertension on BPV.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matteo Alicandri-Ciufelli, Carla Cantaffa, Costanza Galloni, Ignazio Javier Fernandez, Daniele Marchioni, Carlotta Pipolo, Massimiliano Garzaro, Letizia Nitro, Valeria Dell'Era, Francesco Ferella, Massimo Campagnoli, Paolo Russo, Angelo Ghidini, Eugenio De Corso, Daniela Lucidi
{"title":"Impact of single versus multiple surgeries in CRSwNP patients undergoing treatment with dupilumab.","authors":"Matteo Alicandri-Ciufelli, Carla Cantaffa, Costanza Galloni, Ignazio Javier Fernandez, Daniele Marchioni, Carlotta Pipolo, Massimiliano Garzaro, Letizia Nitro, Valeria Dell'Era, Francesco Ferella, Massimo Campagnoli, Paolo Russo, Angelo Ghidini, Eugenio De Corso, Daniela Lucidi","doi":"10.1080/00016489.2025.2481233","DOIUrl":"https://doi.org/10.1080/00016489.2025.2481233","url":null,"abstract":"<p><strong>Background: </strong>Prior to the introduction of biologic drugs, the natural history of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) was characterized by multiple recurrences, thus necessitating multiple surgical interventions.</p><p><strong>Aims/objectives: </strong>To understand whether Dupilumab efficacy in recurrent CRSwNP varies based on number of previous surgeries.</p><p><strong>Materials and methods: </strong>This is a multicentric retrospective study on patients with CRSwNP under Dupilumab, who underwent at least one previous surgery. Correlations between number of previous surgeries and clinical outcomes at baseline and during treatment were investigated.</p><p><strong>Results: </strong>141 patients were included. Mean number of prior surgeries was 2.19 (median 2; range 1-13). For all patients, significant improvements were observed across all time points. Poorer results were observed in patients subjected to more than one prior surgery in terms of NPS at T2 (p .04), SNOT-22 at T4 (p .03), VAS for olfactory dysfunction at T3 (p .01) and T5 (p .009), VAS for nasal obstruction at T4 (p .047), VAS for rhinorrhea at T4 (p .02), VAS for craniofacial pain at T1 (p .02) and T2 (p .04) and of VAS for sleep disturbances at T1 (p .04).</p><p><strong>Conclusions and significance: </strong>Patients subjected to multiple surgeries have worse outcomes during treatment with Dupilumab, particularly for what concerns craniofacial pain and olfactory dysfunction.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preservation of waves VI and VII of ABR in pediatric and adult patients with lesions in bilateral auditory cortices or radiations.","authors":"Ryohei Akiyoshi, Kimitaka Kaga","doi":"10.1080/00016489.2025.2475052","DOIUrl":"https://doi.org/10.1080/00016489.2025.2475052","url":null,"abstract":"<p><strong>Background: </strong>Auditory-evoked brainstem response (ABR) is widely used in various areas of clinical medicine. There is a common understanding regarding the origins of waves I to V in human ABR. However, little is known from where wave VI or VII originates in the central auditory pathway.</p><p><strong>Aims/objectives: </strong>The aim of our research is to elucidate the origins of waves VI and VII by studying ABR amplitude and latency and conducting magnetic resonance imaging (MRI).</p><p><strong>Materials and methods: </strong>Eleven patients diagnosed as having central auditory disorders participated in this study. They include five pediatric patients with herpes simplex infection and six adult patients with cerebrovascular events manifesting auditory agnosia or cortical deafness with lesions in the bilateral auditory cortices.</p><p><strong>Results: </strong>We found that waves VI and VII formed into one complex wave with biphasic peaks and the origin of these waves can be the medial geniculate body (MGB).</p><p><strong>Conclusions: </strong>On the basis of anatomical and electrophysiological findings, we suggest that the latency of VI-I or VII-I nerve conduction time is the auditory brainstem-thalamus transmission time.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}