Does high PD-L1 expression reduce the risk of relapse after definitive surgery in patients with oral cavity cancer?

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

Acta Oto-Laryngologica Pub Date : 2025-04-23 DOI:10.1080/00016489.2025.2489645

Parvin Babayev, Rashad Ismayilov, Oguz Kuscu, Arif Akyildiz, Olcay Kurtulan, Erim Pamuk, Yesim Gaye Guler Tezel, Ibrahim Halil Gullu

{"title":"Does high PD-L1 expression reduce the risk of relapse after definitive surgery in patients with oral cavity cancer?","authors":"Parvin Babayev, Rashad Ismayilov, Oguz Kuscu, Arif Akyildiz, Olcay Kurtulan, Erim Pamuk, Yesim Gaye Guler Tezel, Ibrahim Halil Gullu","doi":"10.1080/00016489.2025.2489645","DOIUrl":null,"url":null,"abstract":"Background: Uncovering the molecular mechanisms of cancer pathogenesis is crucial for improving survival outcomes.Aims: This study investigates the impact of programmed death ligand 1 (PD-L1) expression on the risk of progression in patients with oral squamous cell carcinoma (OSCC).Materials and methods: The retrospective study included adult patients diagnosed with OSCC between January 2012 and December 2023. PD-L1 expression in tissue removed by definitive surgery was evaluated using immunohistochemistry, and tumor proportion score (TPS) and combined positive score (CPS) were calculated. Survival analyses were performed to assess its prognostic implications.Results: Among the 96 patients, TPS and CPS were 20% or above in 52 (54.2%) and 65 (67.7%) cases, respectively. TPS ≥20% was associated with mucosal lip location, earlier disease stage, and decreased risk of progression. The multivariate Cox regression model revealed that stage III/IV disease (HR: 2.176, 95%CI: 1.085-4.376, p = .029) and TPS ≥20% (HR: 0.241, 95%CI: 0.066-0.879, p = .031) were independent risk factors for progression-free survival.Conclusions: The study revealed that increased tumoral PD-L1 expression may reduce the risk of progression in patients with OSCC.Significance: These findings underscore the potential prognostic significance of PD-L1 expression in OSCC following surgical resection.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Oto-Laryngologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00016489.2025.2489645","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Uncovering the molecular mechanisms of cancer pathogenesis is crucial for improving survival outcomes.

Aims: This study investigates the impact of programmed death ligand 1 (PD-L1) expression on the risk of progression in patients with oral squamous cell carcinoma (OSCC).

Materials and methods: The retrospective study included adult patients diagnosed with OSCC between January 2012 and December 2023. PD-L1 expression in tissue removed by definitive surgery was evaluated using immunohistochemistry, and tumor proportion score (TPS) and combined positive score (CPS) were calculated. Survival analyses were performed to assess its prognostic implications.

Results: Among the 96 patients, TPS and CPS were 20% or above in 52 (54.2%) and 65 (67.7%) cases, respectively. TPS ≥20% was associated with mucosal lip location, earlier disease stage, and decreased risk of progression. The multivariate Cox regression model revealed that stage III/IV disease (HR: 2.176, 95%CI: 1.085-4.376, p = .029) and TPS ≥20% (HR: 0.241, 95%CI: 0.066-0.879, p = .031) were independent risk factors for progression-free survival.

Conclusions: The study revealed that increased tumoral PD-L1 expression may reduce the risk of progression in patients with OSCC.

Significance: These findings underscore the potential prognostic significance of PD-L1 expression in OSCC following surgical resection.

查看原文本刊更多论文

高PD-L1表达是否能降低口腔癌患者术后复发的风险？

背景：揭示肿瘤发病的分子机制对改善生存预后至关重要。目的：本研究探讨程序性死亡配体1 （PD-L1）表达对口腔鳞状细胞癌（OSCC）患者进展风险的影响。材料和方法：回顾性研究纳入2012年1月至2023年12月诊断为OSCC的成年患者。应用免疫组织化学方法评估确诊手术切除组织中PD-L1的表达，计算肿瘤比例评分（TPS）和联合阳性评分（CPS）。进行生存分析以评估其预后意义。结果：96例患者中TPS和CPS≥20%的分别为52例（54.2%）和65例（67.7%）。TPS≥20%与粘膜唇部位置、早期疾病阶段和进展风险降低相关。多因素Cox回归模型显示，III/IV期疾病（HR: 2.176, 95%CI: 1.085 ~ 4.376, p = 0.029）和TPS≥20% （HR: 0.241, 95%CI: 0.066 ~ 0.879, p = 0.031）是影响无进展生存的独立危险因素。结论：研究表明，肿瘤PD-L1表达的增加可能降低OSCC患者的进展风险。意义：这些发现强调了手术切除后OSCC中PD-L1表达的潜在预后意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta Oto-Laryngologica 医学-耳鼻喉科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.