Acta Oto-Laryngologica最新文献_第4页

A trend of otologic diseases during the coronavirus disease 2019 pandemic period.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-03 DOI: 10.1080/00016489.2025.2459343

Hye Ah Joo, Byung Chul Kang, Tae Su Kim, Woo Seok Kang, Hong Ju Park, Jong Woo Chung, Joong Ho Ahn

{"title":"A trend of otologic diseases during the coronavirus disease 2019 pandemic period.","authors":"Hye Ah Joo, Byung Chul Kang, Tae Su Kim, Woo Seok Kang, Hong Ju Park, Jong Woo Chung, Joong Ho Ahn","doi":"10.1080/00016489.2025.2459343","DOIUrl":"https://doi.org/10.1080/00016489.2025.2459343","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) changed the practice of medicine, and various anti-contagion restrictions were implemented worldwide.Objectives: This study aimed to evaluate the annual trend in the incidence of otologic diseases during the COVID-19 pandemic and determine the influence of social restrictions on these diseases.Materials and methods: We retrospectively reviewed the number of patients treated for otologic diseases, particularly those associated with infectious pathophysiology, and the total number of patients in the otolaryngology departments at three tertiary referral centers in South Korea.Results: The number of patients who underwent ventilation tube insertion due to persistent otitis media with effusion (OME) significantly decreased (raw number: -37.1%, incidence: -2.04‰) after the onset of the COVID-19 pandemic. However, a sharp increase was observed in 2023 (raw number: +42.9%, incidence: +1.63‰) when the pandemic officially ended. The number of patients newly diagnosed with sudden sensorineural hearing loss (SSNHL) gradually increased during the pandemic period.Conclusions and significance: Restrictive measures to control COVID-19 spread positively influenced the reduction in the incidence of OME. Whether COVID-19 is a direct risk factor for SSNHL remains uncertain, but the potential impact of the virus itself or the COVID-19 vaccine on the auditory system appears to exist.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-evaluating Epstein-Barr virus, human papilloma virus, human cytomegalovirus and human adenovirus in nasal polyps and turbinate mucosa.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2024-12-30 DOI: 10.1080/00016489.2024.2445025

Alexandra Schindele, Anna Holm, Sofie Kraft, Karin Nylander, Annika Allard, Katarina Olofsson

{"title":"Cross-evaluating Epstein-Barr virus, human papilloma virus, human cytomegalovirus and human adenovirus in nasal polyps and turbinate mucosa.","authors":"Alexandra Schindele, Anna Holm, Sofie Kraft, Karin Nylander, Annika Allard, Katarina Olofsson","doi":"10.1080/00016489.2024.2445025","DOIUrl":"https://doi.org/10.1080/00016489.2024.2445025","url":null,"abstract":"Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease in which inflammatory responses to exogenic stressors, such as viral infections, has been recognised. The role of viruses in CRSwNP pathogenesis is unclear.Aims/objectives: We aimed to characterise Epstein-Barr virus (EBV), human papillomavirus (HPV), human cytomegalovirus (HCMV), and human adenovirus (HAdV) in nasal polyps and adjacent paired healthy turbinate mucosa.Materials and methods: We used real-time PCR for EBV, HCMV, and HAdV DNA detection, combined PCR/microarrays for HPV detection and genotyping, in samples from 45 patients with CRSwNP. Additionally, we used EBER in situ hybridisation for EBV detection.Results: EBV detection with EBER-ISH was significantly higher in polyps (36%) versus turbinate mucosa (12%). None of the viral comparisons with PCR between polyps and turbinate mucosa for EBV-, HCMV- or HAdV-DNA showed statistically significant differences. All samples were HPV negative.Conclusions and significance: We report higher expression of EBV in nasal polyps (36%) than in adjacent healthy turbinate mucosa (12%), using a valid method; EBER-ISH in 45 patients with CRSwNP. EBV might be a possible stressor that can trigger polypoid inflammation.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"145 2","pages":"164-167"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Transforming Growth Factor-β1 in the nasal polyp tissue of chronic rhinosinusitis: a comprehensive analysis.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2025-01-29 DOI: 10.1080/00016489.2025.2449709

Iriana Maharani, Loeki Enggar Fitri, Susanthy Djajalaksana, Edi Handoko

{"title":"Identification of Transforming Growth Factor-β1 in the nasal polyp tissue of chronic rhinosinusitis: a comprehensive analysis.","authors":"Iriana Maharani, Loeki Enggar Fitri, Susanthy Djajalaksana, Edi Handoko","doi":"10.1080/00016489.2025.2449709","DOIUrl":"10.1080/00016489.2025.2449709","url":null,"abstract":"Background: Chronic Transforming Growth Factor Beta 1 (TGF-β1) plays a critical role in tissue remodelling and immunological modulation, which may contribute to the severity and recurrence of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Despite extensive research on CRSwNP, the exact role and pathological significance of TGF-β1 in CRSwNP remain poorly understood due to inconsistencies in study methodologies and findings.Aims/objectives: To resolve discrepancies in the literature, this systematic review compares the levels of TGF-β1 in CRSwNP tissue to controls and Chronic Rhinosinusitis without Nasal Polyps (CRSsNP).Material and methods: A comprehensive literature search was conducted across databases such as PubMed, ScienceDirect, and Cochrane Library. Studies assessing TGF-β1 levels in the tissue through various methods were systematically reviewed. Data were extracted on TGF-β1 levels, methodological approaches, and clinical correlations.Results: The review indicates that TGF-β1 levels were highly variable in controls, elevated in CRSsNP, and broadly ranged in CRSwNP with generally lower levels compared to CRSsNP, placing controls between CRSwNP and CRSsNP.Conclusions and significance: Elevated TGF-β1 in CRSsNP points to its significant role in fibrosis and tissue remodeling, which could inform targeted therapeutic approaches and improve management strategies for chronic rhinosinusitis.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"168-175"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic efficacy of canalith reposition maneuver according to the determination method of lesion side in patients with persistent geotropic direction-changing positional nystagmus. 根据病变侧边确定方法的管体复位手法治疗持续性地向性变向体位性眼球震颤的疗效观察。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2025-01-13 DOI: 10.1080/00016489.2024.2449252

Seok Min Hong, Sang Hoon Kim, Jae Yong Byun, Seung Geun Yeo

{"title":"Therapeutic efficacy of canalith reposition maneuver according to the determination method of lesion side in patients with persistent geotropic direction-changing positional nystagmus.","authors":"Seok Min Hong, Sang Hoon Kim, Jae Yong Byun, Seung Geun Yeo","doi":"10.1080/00016489.2024.2449252","DOIUrl":"10.1080/00016489.2024.2449252","url":null,"abstract":"Background: The Canalith Repositioning Maneuver (CRM) is often ineffective for persistent geotropic direction-changing positional nystagmus (DCPN). In these cases, determining the lesion side can be challenging, as the null plane side and the side with stronger nystagmus on the roll test are frequently opposite.Objectives: This study investigates whether the low therapeutic efficacy of CRM in persistent DCPN could be attributed to incorrect determination of the lesion side.Material and methods: This prospective randomized trial involved two groups of patients with persistent geotropic DCPN, categorized based on the method used to determine the lesion side: the null plane side and the side with stronger nystagmus on the head roll test. We assessed the therapeutic efficacy of CRM on the null plane side (null plane group) and the side with stronger nystagmus on the head roll test (stronger nystagmus group).Results: Both groups showed minimal or no immediate therapeutic effect of CRM, with a low short-term effect observed in both as well. No significant differences were found in the immediate and short-term therapeutic effects of CRM between the two groups.Conclusions and significance: The limited therapeutic effect of CRM in persistent geotropic DCPN does not appear to result from incorrect determination of the lesion side.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"140-143"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can switching stimulus polarity identify Meniere's disease? A preliminary investigation on ABR. 刺激极性转换能识别梅尼埃氏病吗？ABR的初步调查。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2025-01-15 DOI: 10.1080/00016489.2024.2447564

Kristi Kaveri Dutta, Anjana Rajesh, C S Vanaja

{"title":"Can switching stimulus polarity identify Meniere's disease? A preliminary investigation on ABR.","authors":"Kristi Kaveri Dutta, Anjana Rajesh, C S Vanaja","doi":"10.1080/00016489.2024.2447564","DOIUrl":"10.1080/00016489.2024.2447564","url":null,"abstract":"Background: Meniere's disease (MD) affects 0.2% to 0.5% of the global population, with regional variations. Standard diagnostic methods, including the glycerol test and EcochG, show variable sensitivity and specificity, highlighting the need for more reliable diagnostic approaches.Objective: This study aims to investigate latency differences in wave V of the Auditory Brainstem Response (ABR) by comparing waveforms for rarefaction and condensation clicks to identify MD.Materials and methods: The study analyzed latency differences in wave V of the ABR using condensation and rarefaction clicks in 15 ears diagnosed with MD. The control groups included 10 ears with sensorineural hearing loss (SNHL) [non-MD ears] and 20 ears with normal hearing sensitivity.Results: MD patients exhibited a significant wave V latency shift between rarefaction and condensation stimuli, suggesting altered cochlear dynamics due to endolymphatic hydrops. No such shift was observed in normal hearing or SNHL ears. Patients with definite MD showed a greater latency difference than those with probable MD, possibly reflecting varying endolymphatic pressure.Discussion: These findings suggest that ABR testing with opposite polarity stimuli could serve as an adjunctive diagnostic tool for MD, particularly in differentiating the severity of the condition but further research is needed to validate these preliminary.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"156-163"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transoral robotic surgery in otolaryngology practice: a single institutional experience. 经口机器人手术在耳鼻喉科的实践：一个单一的机构经验。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2025-01-17 DOI: 10.1080/00016489.2025.2451092

Oguz Kuscu, Enes Dogan, Erim Pamuk

{"title":"Transoral robotic surgery in otolaryngology practice: a single institutional experience.","authors":"Oguz Kuscu, Enes Dogan, Erim Pamuk","doi":"10.1080/00016489.2025.2451092","DOIUrl":"10.1080/00016489.2025.2451092","url":null,"abstract":"Background: Transoral robotic surgery (TORS) has emerged as a minimally invasive technique for managing head and neck pathologies, offering reduced morbidity and improved surgical precision. Despite its growing popularity, institutional experiences with TORS remain limited.Objectives: This study aimed to evaluate the outcomes of TORS for oncological and obstructive sleep apnoea syndrome (OSAS) cases, focusing on efficacy, safety and complications.Materials and methods: A retrospective analysis was conducted on 61 patients who underwent TORS at a single institution between 2018 and 2024. Demographic, surgical and postoperative data were collected, including histopathological findings, complications and hospitalization duration. Statistical analyses were performed using SPSS software (SPSS, Chicago, IL, USA), with significance set at p < .05.Results: Of the 61 patients, 67.2% were male, with a mean age of 57.25 years. TORS was performed for oncological purposes in 72.1% of cases and OSAS in 27.9%. The most common surgical procedure was base-of-tongue resection (42.6%). Postoperative bleeding occurred in 11.4% of cases, all oncological, with two mortalities due to haemorrhage. Hospital readmission within 30 days occurred in 13.1% of patients. OSAS cases demonstrated shorter hospital stays and lower complication rates than oncological cases.Conclusions: TORS is a safe and effective technique for both oncological and OSAS cases, offering significant benefits in reducing morbidity. However, complications, particularly bleeding in oncological cases, remain a challenge, highlighting the need for careful patient selection and perioperative management.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"181-185"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Audiological outcomes and their association with quality of life in patients undergoing stapedotomy.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2024-12-30 DOI: 10.1080/00016489.2024.2445746

Burak Hazır, Çetin Şahutoğlu, Mustafa Çolak, Ağah Yeniçeri, Nagihan Gülhan Yaşar, Aykut İkincioğulları, Hacı Hüseyin Dere

{"title":"Audiological outcomes and their association with quality of life in patients undergoing stapedotomy.","authors":"Burak Hazır, Çetin Şahutoğlu, Mustafa Çolak, Ağah Yeniçeri, Nagihan Gülhan Yaşar, Aykut İkincioğulları, Hacı Hüseyin Dere","doi":"10.1080/00016489.2024.2445746","DOIUrl":"https://doi.org/10.1080/00016489.2024.2445746","url":null,"abstract":"Background: Some preoperative and postoperative audiological outcomes may be associated with quality of life (QoL) in stapedotomy patients.Aims: The aim of this study is to determine which frequencies and conduction pathways improve following this surgery and to assess their effects on QoL.Material and methods: Cases who underwent small fenestra stapedotomy were retrospectively reviewed. Preoperative and postoperative pure tone audiometry were evaluated. The Glasgow Benefit Inventory (GBI) questionnaire was also administered to assess the impact of the operation on their QoL. The relationship between audiologic results and QoL was also examined.Results: A total of 45 ears from 41 patients were included in the study. There is a statistically significant improvement in postoperative mean air conduction (AC), bone conduction (BC) and air-bone gap (ABG) values compared to preoperative values (p < .001). A significant moderate correlation was found between preoperative mean ABG and GBI scores, and between postoperative improvements in AC thresholds and ABG at all frequencies (500, 1,000, 2,000 and 4,000 Hz) and GBI scores (0.3<r < 0.7, p < .05). Among the postoperative BC thresholds, only the improvement at 2,000 Hz was found to have an effect on the GBI score (r = .309, p = .049).Conclusions and significance: Audiological outcomes following stapedotomy had an impact on QoL. Preoperative ABG can be used as an indicator of postoperative QOL.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"145 2","pages":"128-133"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of audiological features and horizontal semicircular canal function at various frequencies in vestibular migraine and Menière's disease. 听力学特征和不同频率水平半规管功能在前庭偏头痛和meni<e:1>病中的作用。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2025-01-15 DOI: 10.1080/00016489.2025.2450222

Ping Guo, Fenghua Qin, Lei Ye, Huawei Li, Wenyan Li

{"title":"The role of audiological features and horizontal semicircular canal function at various frequencies in vestibular migraine and Menière's disease.","authors":"Ping Guo, Fenghua Qin, Lei Ye, Huawei Li, Wenyan Li","doi":"10.1080/00016489.2025.2450222","DOIUrl":"10.1080/00016489.2025.2450222","url":null,"abstract":"Background: Vestibular migraine (VM) and Menière's disease (MD) have numerous overlapping symptoms. Distinguishing the two common recurrent vestibulopathies was challenging.Objectives: To assess the characteristics of hearing loss and the horizontal semicircular canal function in VM and MD.Materials and methods: Various frequency horizontal semicircular canal function tests, including caloric test, video head impulse test (vHIT), and rotatory chair test, as well as multifrequency audiological test with pure-tone average (PTA), were carried out.Results: The hearing threshold of all frequencies in VM is lower than that of MD (p < .05). The phase shift at 0.01 Hz, 0.02 Hz, 0.04 Hz, 0.08 Hz and 0.64 Hz was significantly different in VM and MD patients. The gain at 0.01 Hz differed between VM and MD (p < .05); the time constant (RTc) in VM patients was longer than that of MD patients (p < .05). The incidence of caloric test abnormality was 40% in VM patients and 68.3% in MD patients. The abnormal rate of horizontal semicircular canal vHIT was 3.2% in VM and 5.8% in the MD, and the rates of overt/cover saccades were 9.7% and 17.6%, respectively.Conclusions: The degree and type of hearing loss were conducive to distinguishing between VM and MD, and the rotatory chair test was a necessary supplement.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"115-122"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of adult tonsillectomy for hypertrophic indications in Southwest Finland. 芬兰西南部成人扁桃体切除术治疗肥大指征的发生率。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2025-01-11 DOI: 10.1080/00016489.2024.2448823

Henrik M Sjöblom, Jenny C Knubb, Tommi Kauko, Jaakko Pulkkinen, Jaakko M Piitulainen

{"title":"Incidence of adult tonsillectomy for hypertrophic indications in Southwest Finland.","authors":"Henrik M Sjöblom, Jenny C Knubb, Tommi Kauko, Jaakko Pulkkinen, Jaakko M Piitulainen","doi":"10.1080/00016489.2024.2448823","DOIUrl":"10.1080/00016489.2024.2448823","url":null,"abstract":"Background: Large palatine tonsils cause a variety of symptoms including obstructive sleep apnea and snoring. In adults, the prevalence of tonsillar hypertrophy remains uncertain.Aims: We estimated the incidence of tonsillectomy for adult palatine tonsillar hypertrophy using population data and retrospective patient charts.Material and methods: Patient data were retrospectively collected between 2004 and 2018 in the Hospital District of Southwest Finland. Adult patients with tonsil hypertrophy, obstructive sleep apnea or mouth breathing/snoring as an indication for surgery were included. Data were verified from patient charts. To determine in adults the incidence of tonsillectomy for tonsillar hypertrophy, the number of surgeries was compared to population data.Results: The incidence of tonsillectomy for adult tonsillar hypertrophy was 8.49 per 100000 person-years. In our hospital district, 9.5% of adults who underwent tonsil surgery had tonsillar hypertrophy. The incidence rate reduced with age. The most common indication for surgery of hypertrophic tonsils was snoring (30.8%). In this study, 12.7% of patients with asymmetric tonsils had malignancy with the most common being lymphoma.Conclusions and significance: Symptomatic adult tonsil hypertrophy remains rare. In adults, tonsil asymmetry should invoke a suspicion of lymphoma. Even during adulthood, as age increases, tonsillar hypertrophy becomes less common.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"176-180"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolome modification and underlying biomarker of noise-induced hearing loss Guinea pig cochlear fluid. 噪声性听力损失豚鼠耳蜗液的代谢组修饰和潜在生物标志物。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2025-01-15 DOI: 10.1080/00016489.2024.2445738

Guowei Qi, Jinge Tang, Handai Qin, Runnan Han, Qingqing Jiang, Ning Yu, Shiming Yang, Dongyi Han

{"title":"Metabolome modification and underlying biomarker of noise-induced hearing loss Guinea pig cochlear fluid.","authors":"Guowei Qi, Jinge Tang, Handai Qin, Runnan Han, Qingqing Jiang, Ning Yu, Shiming Yang, Dongyi Han","doi":"10.1080/00016489.2024.2445738","DOIUrl":"10.1080/00016489.2024.2445738","url":null,"abstract":"Background: Noise-induced hearing loss (NIHL) is a kind of acquired sensorineural hearing loss and has shown an increasing incidence in recent years. Hence, elucidating the exact pathophysiological mechanisms and proposing effective treatment and prevention methods become the top priority. Though a great number of researches have been carried out on NIHL, few of them were focused on metabolites.Aims/objectives: To reveal the metabolomic changes in cochlear fluid after noise injury and search for underlying inner ear biomarkers of NIHL.Material and methods: In this study, cochlea fluid extracted from guinea pigs after impulse noise exposure were subjected to GC-MS and LC-MS untargeted metabolomics analysis.Results: After impulse noise exposure, 62 significantly changed metabolites in guinea pig cochlea fluid were screened out and deoxyribose 1-phosphate was selected as the key metabolite and underlying biomarker for NIHL. KEGG pathway analysis showed that oxidative phosphorylation, glycerophospholipid metabolism, pyrimidine metabolism and pentose phosphate pathway were significantly changed at all observed time points after noise.Conclusions and significance: This study effectively promoted the application of metabolomics in hearing research. The pathophysiology process of NIHL in the inner ear was closely connected with oxidative phosphorylation, glycerophospholipid metabolism, pyrimidine metabolism and pentose phosphate pathway and deoxyribose 1-phosphate could be the biomarker for NIHL.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"101-114"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0