Acta Oto-Laryngologica最新文献

{"title":"Segmentation-guided peritumoral radiomics and machine learning for ultrasound-based classification of salivary gland tumors.","authors":"Hung-Wei Chen, Chin-Huan Chang, Wei-Chen Hung, Chih-Ming Chang, Po-Wen Cheng, Wu-Chia Lo, Li-Jen Liao, Ping-Chia Cheng","doi":"10.1080/00016489.2026.2722468","DOIUrl":"https://doi.org/10.1080/00016489.2026.2722468","url":null,"abstract":"<p><strong>Background: </strong>Preoperative differentiation of benign and malignant salivary gland tumors (SGTs) remains challenging because of overlapping ultrasonographic features.</p><p><strong>Objectives: </strong>To develop and validate a segmentation-guided machine learning model using peritumoral radiomic features for ultrasound-based classification of SGTs.</p><p><strong>Materials and methods: </strong>A YOLOv8 segmentation model was developed using 366 ultrasound images collected between January 2007 and June 2022. Automated tumor segmentation generated a standardized peritumoral ribbon for extracting 15 radiomic features characterizing tumor morphology, boundary microtexture, and boundary-to-core properties. After correlation-based feature selection, five machine learning classifiers were developed and evaluated in an independent testing cohort (<i>n</i> = 121; July 2022-December 2024) and an internal validation cohort (<i>n</i> = 51; January-December 2025).</p><p><strong>Results: </strong>The YOLOv8 model achieved Dice coefficients of 0.9485 and 0.8896 in the training and testing cohorts, respectively. Twelve radiomic features were retained for model development. Among the evaluated classifiers, the Support Vector Classifier (SVC) demonstrated the best performance, achieving AUCs of 0.8117 and 0.7951 in the testing and validation cohorts, respectively. The complete pipeline was implemented as both standalone and web-based applications.</p><p><strong>Conclusions: </strong>Segmentation-guided peritumoral radiomics combined with machine learning represents an interpretable and promising adjunctive approach for ultrasound-based classification of salivary gland tumors.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammatory indices primarily reflect tumor burden rather than independently predict prognosis in HPV-associated oropharyngeal squamous cell carcinoma.","authors":"Tomotaka Kakubari, Hideyuki Takahashi, Tomohiro Shimizu, Miho Uchida, Hiroe Tada, Kazuaki Chikamatsu","doi":"10.1080/00016489.2026.2726027","DOIUrl":"https://doi.org/10.1080/00016489.2026.2726027","url":null,"abstract":"<p><strong>Objectives: </strong>Approximately 30% of patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) have poor outcomes despite standardized treatment. Reliable biomarkers for identifying high-risk patients remain insufficiently established.</p><p><p>To investigate the clinical significance of systemic inflammatory indices for identifying high-risk patients and to explore their associations with clinicopathological characteristics.</p><p><strong>Methods: </strong>A total of 99 patients with HPV-associated (p16-positive) OPSCC were included. Systemic inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), prognostic nutritional index (PNI), C-reactive protein-to-albumin ratio (CAR), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI), were evaluated for their associations with clinical outcomes and clinicopathological characteristics. Their prognostic significance was assessed using Cox proportional hazards regression and Kaplan-Meier survival analyses.</p><p><strong>Results: </strong>Most systemic inflammatory indices were associated with overall survival (OS) in univariate analysis, whereas only NLR was associated with progression-free survival (PFS); furthermore, none remained independently significant in multivariate analyses. Notably, all indices were significantly associated with T classification, whereas associations with N and M classifications were limited.</p><p><strong>Conclusions: </strong>Systemic inflammatory indices primarily reflected tumor burden rather than serving as independent prognostic determinants in HPV-associated OPSCC. Biomarkers derived from the local tumor immune microenvironment may provide more informative tools for risk stratification and treatment optimization.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A descriptive histopathological framework for radiotherapy-related muscle injury in salvage surgery for hypopharyngeal cancer.","authors":"Hideoki Uryu, Ryosuke Kuga, Hidetaka Yamamoto, Torahiko Nakashima","doi":"10.1080/00016489.2026.2724803","DOIUrl":"https://doi.org/10.1080/00016489.2026.2724803","url":null,"abstract":"<p><strong>Background: </strong>Radiotherapy-related normal tissue injury is clinically important in salvage surgery for hypopharyngeal cancer, but its histopathological features in clinical specimens remain poorly defined.</p><p><strong>Aims/objectives: </strong>To propose a practical descriptive histopathological framework for radiotherapy-related muscle injury using salvage surgical specimens.</p><p><strong>Material and methods: </strong>We retrospectively examined anterior cervical muscle specimens obtained during salvage total pharyngolaryngectomy after definitive radiotherapy or chemoradiotherapy. Two head and neck surgeons with postgraduate training in pathology independently reviewed H&E-stained sections without reference to treatment exposure and, after discussion, established a four-tier semiquantitative framework based on recurring morphologic patterns. A board-certified head and neck pathologist subsequently reviewed all specimens blinded to treatment exposure and clinical information. No statistical comparison between treatment groups was intended.</p><p><strong>Results: </strong>Thirteen previously irradiated patients and two non-irradiated controls were included. Irradiated muscles showed a spectrum of changes ranging from mild myofiber swelling and atrophy to rupture, fibrosis, necrosis, and scarring. Non-irradiated controls showed preserved muscle architecture.</p><p><strong>Conclusions and significance: </strong>This study proposes a practical descriptive framework for radiotherapy-related muscle injury in salvage surgery. The grades should be interpreted as predominant morphologic patterns rather than rigid chronological stages or statistically validated treatment-specific categories.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geniculate ganglion 'hemangiomas'-venous malformations: from a pathologic to a therapeutic paradigm shift.","authors":"Matteo Alicandri-Ciufelli, Chiara Devoti, Gianluca di Massa, Albino Eccher, Daniele Marchioni, Giacomo Colletti","doi":"10.1080/00016489.2026.2722603","DOIUrl":"https://doi.org/10.1080/00016489.2026.2722603","url":null,"abstract":"<p><strong>Background: </strong>Vascular lesions historically named 'geniculate ganglion hemangiomas' (GGH) require clinical and biological re-evaluation.</p><p><strong>Aims/objectives: </strong>To challenge the historical nomenclature of 'geniculate ganglion hemangiomas' and to explore the implications of their reclassification as venous malformations (VMs), focusing on function-preserving and minimally invasive strategies.</p><p><strong>Material and methods: </strong>Retrospective clinical, surgical, and histopathologic reviews of six patients treated for geniculate ganglion vascular lesions at a tertiary referral center. Surgical approaches included endoscopic ear surgery (EES) and middle cranial fossa (MCF) approaches. Specimens were re-evaluated according to ISSVA criteria.</p><p><strong>Results: </strong>All patients presented with facial nerve dysfunction and underwent complete surgical excision. Nerve grafting or reanimation procedures were required in four cases. Histopathologic and immunohistochemical findings in all cases were consistent with slow-flow VMs rather than true hemangiomas.</p><p><strong>Conclusions: </strong>These lesions should be reclassified as geniculate ganglion venous malformations (GGVMs) according to ISSVA criteria. Their non-neoplastic nature challenges mandatory radical excision. Minimally invasive EES offers a potential corridor for targeted, function-preserving strategies, though non-resective modalities remain unvalidated in this cohort and require future trial investigation.</p><p><strong>Significance: </strong>This shift potentially redefines preoperative counseling and surgical decision-making paradigm. EES offers a minimally invasive corridor, potentially allowing targeted therapies, thereby minimizing facial nerve morbidity.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-generated <i>versus</i> standard informed consent forms in otolaryngology: a blinded multirater pilot feasibility study.","authors":"Oktay Bakin, Eray Uzunoglu, Tankut Uzun, Muhammed Kursad Guclu, Togay Muderris","doi":"10.1080/00016489.2026.2724806","DOIUrl":"https://doi.org/10.1080/00016489.2026.2724806","url":null,"abstract":"<p><strong>Background: </strong>Informed consent documents often exceed recommended readability levels, potentially compromising patients' decision-making.</p><p><strong>Aims/objectives: </strong>This pilot feasibility study evaluated two large language models (LLMs), ChatGPT-5.2 and Gemini 3 Pro, as tools for generating more comprehensible otolaryngology surgical consent forms, and estimated effect-size parameters for a future trial.</p><p><strong>Materials and methods: </strong>In a prospective, double-blind design, 123 Turkish consent documents (41 procedures × 3 sources: official forms, ChatGPT-5.2 and Gemini 3 Pro) were evaluated. Three independent otolaryngologists rated medical quality on five 5-point criteria; five blinded lay volunteers rated comprehensibility. Two validated Turkish readability indices (Ateşman; Bezirci-Yılmaz) provided objective measurement. Comparisons used linear mixed-effects models.</p><p><strong>Results: </strong>Official forms showed the highest expert-rated quality (4.62 ± 0.35) versus ChatGPT5.2 (3.85 ± 0.48) and Gemini 3 Pro (3.99 ± 0.44; <i>p</i> < 0.001). Gemini forms achieved the highest comprehensibility (4.33 ± 0.42 vs 3.18 ± 0.51 for official forms; <i>p</i> < 0.001). Objective readability mirrored this, with the Ateşman score correlating with comprehensibility (<i>r</i> = 0.81).</p><p><strong>Conclusions and significance: </strong>Publicly available LLMs, particularly Gemini 3 Pro, can substantially improve consent-form comprehensibility at some cost to medical-accuracy and ethical-legal adequacy; these findings motivate evaluation of a hybrid AI-plus-expert workflow in a future confirmatory trial.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear implantation in older adults: current routine and needs - a multi-centre scoping survey.","authors":"Dayse Távora-Vieira, Miryam Calvino, Christiane Völter, Javier Gavilán, David Strachan, Vedat Topsakal, Paul Van de Heyning, Sasidharan Pulibalathingal, Mohan Kameswaran, Domenico Cuda, Rudolf Hagen, Stefan Dazert, Timo Stöver, Christopher Raine, Kristen Rak, Mario Zernotti, Serafima Sugarova, Hinrich Staecker, Vincent Van Rompaey, Shin-Ichi Usami, Luis Lassaletta, Robert Mlynski, Uwe Baumann, Marco Caversaccio, Lorne S Parnes, Ranjith Rajeswaran, Tashneem Harris, Aanand Acharya, Griet Mertens","doi":"10.1080/00016489.2026.2725513","DOIUrl":"https://doi.org/10.1080/00016489.2026.2725513","url":null,"abstract":"<p><strong>Background: </strong>Research on the hearing implant journey in older adults is scarce.</p><p><strong>Aims/objectives: </strong>To conduct a multicenter scoping survey on the clinical routine in the treatment of hearing loss, specifically cochlear implantation, in older adults.</p><p><strong>Materials and methods: </strong>A survey comprising 39 questions on the treatment of hearing loss in older adults was sent to 20 cochlear implant clinics worldwide.</p><p><strong>Results: </strong>Most respondents referred to older adults in the context of cochlear implantation as adults aged 60 years or older with postlingual, mostly progressive hearing loss with different aetiologies. Preoperative assessment in older adults should go beyond standard audiometric tests, including cognitive screening and involving a multidisciplinary team. Significant others and social support play a key role in the rehabilitation process in older adult CI recipients and users.</p><p><strong>Conclusions and significance: </strong>A guideline for the management of cochlear implantation in older adults is needed.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal irrigation increases upper-airway microbial diversity: a prospective pilot study.","authors":"Shoichi Kimura, Kensuke Nishi, Kensuke Kawamoto, Yasuhito Mihashi, Tatsuro Nishi, Toshifumi Sakata, Nozomu Matsumoto, Takafumi Yamano, Yoshio Nakano, Nao Suzuki","doi":"10.1080/00016489.2026.2721206","DOIUrl":"10.1080/00016489.2026.2721206","url":null,"abstract":"<p><strong>Background: </strong>Nasal irrigation is widely recommended for chronic rhinosinusitis and allergic rhinitis, but its effects on the upper-airway microbiome remain unclear.</p><p><strong>Objective: </strong>To determine whether 30 days of buffered isotonic saline nasal irrigation alters bacterial diversity in the nasal cavity, nasopharynx, and oral cavity.</p><p><strong>Material and methods: </strong>Ten volunteers performed twice-daily irrigation for 30 days. Swabs from the nasal cavity, nasopharynx, and posterior tongue were collected at baseline and day 30. Bacterial communities were analysed by 16S rRNA gene sequencing. The primary endpoint was change in nasal Shannon diversity; other microbiome, endoscopic, and correlation analyses were exploratory.</p><p><strong>Results: </strong>Nasal Shannon diversity increased significantly (median [IQR], 1.02 [0.80-1.48] vs <b>1.50 [1.37-1.66]; <i>p</i> = 0.040)</b>, whereas nasopharyngeal and oral diversity did not. Micrococcaceae, Lactobacillus, and Corynebacterium showed directional increases but did not survive FDR correction. Nasal mucosal erythema decreased (<i>p</i> = 0.039). No participant developed acute sinusitis or severe complications; transient mild discomfort occurred in three.</p><p><strong>Conclusions and significance: </strong>Thirty-day saline nasal irrigation was associated with increased nasal bacterial diversity and reduced mucosal erythema. These single-arm pilot findings are exploratory and warrant validation in larger controlled studies.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of hearing loss and tinnitus after childhood cancer treatment: a Danish nationwide registry-based study.","authors":"Lone Jantzen, Signe Wischmann, René Mathiasen, Per Cayé-Thomasen, Lone Percy-Smith","doi":"10.1080/00016489.2026.2717008","DOIUrl":"https://doi.org/10.1080/00016489.2026.2717008","url":null,"abstract":"<p><strong>Background: </strong>Despite rising survival rates and high-quality health data available - no large-scale study has mapped the full Danish Childhood Cancer Survivor population with auditory late effects.</p><p><strong>Aims/objectives: </strong>This study aimed to estimate the prevalence of auditory late effects among Danish children and adolescents diagnosed with cancer in a national register-based study.</p><p><strong>Materials and methods: </strong>Using data from the Danish Cancer Register and the Danish National Patient Register, we identified children diagnosed with cancer before the age of 18 between 2014 and 2024. Statistical analyses including descriptive statistics, chi-square tests, relative risks and trend analysis were performed to explore patterns and potential associations between cancer diagnosis and the development of auditory late effects.</p><p><strong>Results: </strong>The study population consisted of 3075 children with a registration in the Danish Cancer Register. The prevalence of auditory late effects was 5.7%. The risk was higher among younger patients, patients with malignant neoplasms and patients receiving high-dose chemotherapy at a younger age..</p><p><strong>Conclusion and significance: </strong>These findings highlight auditory late effects as a relevant late effect with implications for quality of life. Early identification and monitoring are essential to support developmental outcomes, particularly in younger patients, and to increase awareness in survivorship care.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological analysis of 400 cervical lymph node biopsies in patients with suspected malignancy.","authors":"Demet Yazıcı, Şükrü Alper Otamış, Yakup Acar, İlhami Yıldırım","doi":"10.1080/00016489.2026.2664549","DOIUrl":"10.1080/00016489.2026.2664549","url":null,"abstract":"<p><strong>Background: </strong>Cervical lymphadenopathy has a wide differential diagnosis ranging from benign inflammatory conditions to malignant diseases. When clinical evaluation and cytological methods are inconclusive, surgical lymph node biopsy remains the gold standard for definitive diagnosis.</p><p><strong>Aims/objectives: </strong>This study aimed to evaluate the clinicopathological distribution of diagnostic cervical lymph node biopsies performed in patients with cervical lymphadenopathy at a tertiary referral center.</p><p><strong>Material and methods: </strong>This retrospective study included 400 patients who underwent excisional or incisional cervical lymph node biopsy for diagnostic purposes between January 2021 and December 2025.</p><p><strong>Results: </strong>The mean age was 37.2 ± 22.4 years; 51.2% of patients were male and 25.3% were younger than 18 years. 57.2% of the biopsies were malignant, 39.2% benign, and 3.5% non-diagnostic. Malignancy was associated with male sex, older age, and larger lymph node size; the malignancy rate reached 92.9% when the lymph node size was ≥5 cm. The most frequent malignant category was leukemia/lymphoma (41.5%), followed by metastatic malignancy (14.5%).</p><p><strong>Conclusions and significance: </strong>Surgical biopsy for cervical lymphadenopathy provides a high diagnostic yield in a tertiary care setting, with a substantial malignancy burden. Early tissue diagnosis may reduce diagnostic delay, particularly for large (≥5 cm) and lower-neck/supraclavicular lymph nodes.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1075-1083"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of vestibular tests (video head impulse test and cervical vestibular evoked myogenic potentials) in idiopathic sudden sensorineural hearing loss.","authors":"Concepción Rodríguez-Izquierdo, Anastasiya Avdiyuk, Daniel Rodríguez-Ocaña, Guillermo Plaza","doi":"10.1080/00016489.2026.2671348","DOIUrl":"10.1080/00016489.2026.2671348","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic sudden sensorineural hearing loss (ISSHL) can be associated with vestibular organ involvement, which may influence it prognosis.</p><p><strong>Objective: </strong>Evaluate vestibular function in ISSNHL without acute vestibular syndrome (AVS) and to examine associations with baseline hearing loss.</p><p><strong>Material and methods: </strong>Prospective cohort study of adults (18-65 years) with ISSNHL treated between February 2024 and September 2025. Video head impulse test (vHIT) and cervical vestibular evoked myogenic potentials (cVEMPs) was performed within the first month and at 6 months from diagnosis. All patients received high-dose systemic corticosteroids with salvage intratympanic corticosteroids.</p><p><strong>Results: </strong>39 patients were included. During the first month, vHIT gain was abnormal in 23.1%, predominantly involving the posterior canal (66.7%) and cVEMPs were abnormal in 79.5%. Complete recovery was highest in mild loss (90.9%; <i>p</i> = 0.02). Recovery was not associated with abnormal vHIT (<i>p</i> = 0.663) or abnormal/absent cVEMPs (<i>p</i> = 0.436). In severe/profound hearing loss, statistically significant differences were found between the degree of hearing loss and the presence of abnormal vHIT (<i>p</i> = 0.011) and cVEMP (<i>p</i> = 0.023) at 6 months.</p><p><strong>Conclusions: </strong>Subclinical vestibular dysfunction is frequent in ISSNHL without AVS.</p><p><strong>Significance: </strong>Baseline hearing severity predicts short-term outcome, while vHIT and cVEMP abnormalities were not independent prognostic markers in our cohort.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1131-1136"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}