Acta Oto-Laryngologica最新文献_第4页

Minigene assay for verifying the splicing effects of the rare variants in the SLC12A2 gene at c.2930-1G>a.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-14 DOI: 10.1080/00016489.2025.2475486

Lin Mengsi, Zhu Qingwen, Cui Aimin, Wang Jing

{"title":"Minigene assay for verifying the splicing effects of the rare variants in the SLC12A2 gene at c.2930-1G>a.","authors":"Lin Mengsi, Zhu Qingwen, Cui Aimin, Wang Jing","doi":"10.1080/00016489.2025.2475486","DOIUrl":"10.1080/00016489.2025.2475486","url":null,"abstract":"Background: Hearing loss (HL) is a prevalent sensory impairment with a genetic basis. The SLC12A2 gene, encoding NKCC1, is vital for inner ear ion balance. The c.2930-1G > A variant is a novel mutation potentially linked to sensorineural hearing loss.Objectives: To investigate the splicing and protein expression effects of the c.2930-1G>A variant in SLC12A2 and its role in hearing loss.Material and methods: Minigene assays and plasmid transfection in HEK-293T and Hela cells were used to study splicing. Protein expression and modification were also assessed.Results: The c.2930-1G>A variant caused partial exon skipping, altering mRNA splicing in both cell types. This suggests a potential involvement in sensorineural hearing loss. Protein analysis showed the E21del mutation increased expression without altering modification patterns, whereas the 2930_2977del mutation reduced both, possibly impacting stability or modification sites.Conclusions and significance: The c.2930-1G>A variant likely contribute to hearing loss by disrupting splicing and protein expression. Currently a Variant of Uncertain Significance (VUS), its pathogenicity is supported by these findings. Further research is needed to confirm its role, emphasizing the need for integrated genetic and clinical data in auditory disorders management.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allogeneic composite amniotic membrane in tympanic membrane repair: a randomized parallel controlled study.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-13 DOI: 10.1080/00016489.2025.2475487

Anchi Sun, Rongrong Lv, Zhiwei Xing, Xiaomin Wang, Mingjie Zhang, Mengjun Wang, Qianqian Shao, Hui Li

{"title":"Allogeneic composite amniotic membrane in tympanic membrane repair: a randomized parallel controlled study.","authors":"Anchi Sun, Rongrong Lv, Zhiwei Xing, Xiaomin Wang, Mingjie Zhang, Mengjun Wang, Qianqian Shao, Hui Li","doi":"10.1080/00016489.2025.2475487","DOIUrl":"https://doi.org/10.1080/00016489.2025.2475487","url":null,"abstract":"Backgrounds: Composite amniotic membranes have been widely used in ophthalmology and orthopedics. For the repair of tympanic membrane perforation, the introduction of amniotic membrane is still under study.Objectives: To analyse the effectiveness of a homograft composite amniotic membrane in tympanic membrane repair.Methods: A total of 76 patients were recruited and randomly assigned to the experimental group (n = 39) and the control group (n = 37). The test group employed a composite amniotic membrane for the repair of the tympanic membrane, while the control group utilized cartilage from the auricular for the same purpose. The efficacy of composite amniotic membrane was evaluated through a comparative analysis of postoperative tympanic membrane healing, complications, and hearing recovery.Results: Hearing improved significantly in both groups, but there was no significant difference between the two groups. The results of the postoperative pain scores demonstrated that the majority of patients were experiencing mild pain, with a notable discrepancy between the test group and the control group. Intraoperative bleeding time was also significantly lower in the test group than in the control group.Conclusion: Allogeneic composite amniotic membrane can be used as a material for repairing tympanic membrane perforation, which can effectively improve postoperative hearing of patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative outcome of palatine tonsillectomy by tonsil pillar suture with knot-free suture.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-13 DOI: 10.1080/00016489.2025.2476191

Yusei Yamaguchi, Shinya Ohira, Kota Wada

{"title":"Postoperative outcome of palatine tonsillectomy by tonsil pillar suture with knot-free suture.","authors":"Yusei Yamaguchi, Shinya Ohira, Kota Wada","doi":"10.1080/00016489.2025.2476191","DOIUrl":"10.1080/00016489.2025.2476191","url":null,"abstract":"Background: Postoperative haemorrhage following palatine tonsillectomy occurs in 5-14% of cases. Since 2021, our department has used knot suturing with 3-0 Vicryl, and from 2023, continuous suturing with the V-Loc™ closure device to reduce suture time. While knot suturing is reported to reduce postoperative bleeding and pain, no studies have compared outcomes between different suture methods.Aims: This study retrospectively analysed postoperative bleeding, pain, and complications in 125 patients undergoing palatine tonsillectomy, with or without sutures.Methods: Patients aged ≥15 years who underwent bilateral tonsillectomy from October 2019 to March 2024 were grouped into no-suture, knot-suture, and knot-free-suture categories. Data on operative time, pain, bleeding, suture dissection, and complications were compared using the Mann-Whitney U test for continuous variables and the chi-square test for nominal variables.Results: Knot-free sutures had the shortest operative time (53 ± 16 min) compared to no sutures (62 ± 19 min) and knot sutures (94 ± 22 min). Pain decreased over time across all groups. Bleeding rates were similar, though knot-free sutures required frequent removal (76%). Knot sutures had a significantly lower dissection rate (<0.001).Conclusions and significance: Knot-free sutures improve surgical efficiency but may require additional postoperative interventions, representing a cost-effective alternative to high-energy devices.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of functional and aesthetic outcomes following open technique septorhinoplasty: assessing the utility and correlation of the Rhinoplasty Health Inventory and Nasal Outcomes, Rhinoplasty Outcome Evaluation, and Nasal Obstructive Symptom Evaluation questionnaires.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-13 DOI: 10.1080/00016489.2025.2477210

Gamze Ozturk Yilmaz, Gokhan Yilmaz

{"title":"Evaluation of functional and aesthetic outcomes following open technique septorhinoplasty: assessing the utility and correlation of the Rhinoplasty Health Inventory and Nasal Outcomes, Rhinoplasty Outcome Evaluation, and Nasal Obstructive Symptom Evaluation questionnaires.","authors":"Gamze Ozturk Yilmaz, Gokhan Yilmaz","doi":"10.1080/00016489.2025.2477210","DOIUrl":"https://doi.org/10.1080/00016489.2025.2477210","url":null,"abstract":"Background: The importance of subjective quality of life questionnaires in evaluating post-rhinoplasty outcomes and patient satisfaction is increasing.Objective: This study aimed to measure the aesthetic and functional satisfaction of patients following septorhinoplasty using the Rhinoplasty Health Inventory and Nasal Outcomes (RHINO), Rhinoplasty Outcome Evaluation (ROE), and Nasal Obstructive Symptom Evaluation (NOSE) questionnaires.Methods: This prospective study included 306 patients who underwent a primary open-technique septorhinoplasty. The NOSE, ROE, and RHINO questionnaires were given to all patients before surgery and in the sixth month following surgery.Results: Preoperative NOSE, ROE, and RHINO scores significantly improved postoperatively in all patients (p < .001). Postoperative satisfaction was higher among young people, women, those with functional indications, single people, and those who were unemployed. Additionally, positive correlation existed between the RHINO and ROE scores (p < .001), and negative correlation existed between the postoperative RHINO and NOSE scores (p < .001).Conclusions: Thus, septorhinoplasty likely improves the functional and aesthetic quality of life in all patients. Our results suggest that a patient who scores favorable on the NOSE and ROE questionnaires is also likely to score favorable on the RHINO questionnaire.Significance: It is possible to evaluate septorhinoplasty results both functionally and aesthetically using just one questionnaire.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of nasal functions in Behçet's and neuro-Behçet's patients.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-03-01 DOI: 10.1080/00016489.2025.2470981

Sumeyye Gencer Culha, Mansur Dogan

{"title":"Evaluation of nasal functions in Behçet's and neuro-Behçet's patients.","authors":"Sumeyye Gencer Culha, Mansur Dogan","doi":"10.1080/00016489.2025.2470981","DOIUrl":"10.1080/00016489.2025.2470981","url":null,"abstract":"Background: Behçet's disease (BD) is a multisystemic inflammatory disease.Objectives: The aim of our study is to investigate whether BD and neuro-Behçet's disease (ND) cause any changes in nasal and olfactory functions.Materials and methods: Our study included 20 patients with BD (group BD), 17 patients with ND (group NB), and a control group of 20 healthy volunteers (group C). Participants underwent nasal endoscopic examination, peak nasal inspiratory flow (PNIF) test to assess nasal airway patency, saccharin test to measure mucociliary clearance and Sniffin' Sticks smell test to assess olfactory dysfunction.Results: In our study, when the groups were examined in terms of saccharin values, it was found to be statistically significantly longer in group BD and group NB (p < .001). In the odor discrimination test, a statistically significant difference was found only between group NB and group C. The odor identification test and total scores were found to be lower in group BD and group NB.Conclusions and significance: The results obtained in this study demonstrate that mucociliary activity and olfactory functions are significantly impaired in both the BD and NB groups.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of basic-fibroblast growth factor on tympanic membrane perforation in a mouse model of blast injury. 碱性成纤维细胞生长因子对爆炸伤小鼠模型鼓膜穿孔的影响

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-28 DOI: 10.1080/00016489.2025.2470971

Motohiro Sato, Kunio Mizutari, Takaomi Kurioka, Yoshiaki Inuzuka, Shingo Yasutake, Koji Araki, Yasushi Satoh, Akihiro Shiotani

{"title":"Effect of basic-fibroblast growth factor on tympanic membrane perforation in a mouse model of blast injury.","authors":"Motohiro Sato, Kunio Mizutari, Takaomi Kurioka, Yoshiaki Inuzuka, Shingo Yasutake, Koji Araki, Yasushi Satoh, Akihiro Shiotani","doi":"10.1080/00016489.2025.2470971","DOIUrl":"https://doi.org/10.1080/00016489.2025.2470971","url":null,"abstract":"Background: Tympanic membrane perforation (TMP) caused by blast injury result in poor TMP closure and pathological regeneration of the tympanic membrane (TM). TM regeneration therapy using basic fibroblast growth factor (bFGF) has demonstrated good outcomes for chronic otitis media.Aims/objectives: To investigate the efficacy of bFGF treatment in the management of blast-induced TMP.Material and methods: Male CBA/J mice (10-12-week-old) were divided into the bFGF-treatment and no-treatment groups. Blast-tube systems were used to induce TMP. Auditory evaluation, TM observation, histological evaluation of the regenerated TM, and histological evaluation of the inner ear were conducted.Results: Auditory assessment revealed no difference between the groups, with persistent auditory threshold elevation being observed even 1 month post-injury. Similarly, histological evaluation of the inner ear hair cells revealed no significant differences between the groups; no hair cell death was evident. However, the regenerated TM in the bFGF-treated group was significantly thicker than that in the untreated group.Conclusions and significance: A good TMP closure rate was observed in the present study; however, bFGF treatment exacerbated thickening of the regenerated TM. Future studies must study the therapeutic effects of bFGF treatment using various animal models and timing and concentration of bFGF treatment.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of polysomnography data and inflammatory markers after sleep surgery.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-27 DOI: 10.1080/00016489.2025.2470304

Öznur Gündüz, Şeyda Akbal Çufalı

{"title":"Correlation of polysomnography data and inflammatory markers after sleep surgery.","authors":"Öznur Gündüz, Şeyda Akbal Çufalı","doi":"10.1080/00016489.2025.2470304","DOIUrl":"https://doi.org/10.1080/00016489.2025.2470304","url":null,"abstract":"Background: The occurrence of hypoxia during apneas and hypopneas is associated with the triggering of an inflammatory response.Objectives: This study investigates the alterations in polysomnography (PSG) data, inflammatory markers, and the correlation between these alterations in patients undergoing sleep surgery.Methods: The data of 66 patients who underwent drug-induced sleep endoscopy followed by appropriate sleep surgery, with follow-up PSG performed at 3 to 6 months postoperatively, were retrospectively analyzed. Additionally, correlations with inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), eosinophil-to-lymphocyte ratio (ELR) and systemic immune-inflammation index (SII), were investigated.Results: Comparison of preoperative and postoperative inflammatory markers revealed statistically significant reductions in NLR, PLR, and SII (p < 0.001, p = 0.023, p = 0.026, respectively). Significant positive correlations were identified between AHI and NLR (p = 0.001, r = 0.400), PLR (p = 0.001, r = 0.415) and SII (p = 0.010, r = 0.392). Similarly, a significant positive correlation was observed between supine AHI and NLR (p = 0.035, r = 0.379), PLR (p = 0.008, r = 0.325), and SII (p = 0.030, r = 0.367). The time spent with SaO2 below 90% was found to be significantly and positively correlated with NLR (p = 0.023, r = 0.279), PLR (p = 0.027, r = 0.272), and SII (p = 0.033, r = 0.256).Conclusions and significance: A correlation was observed between the postoperative decrease in SII, NLR, and PLR values and PSG data in patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of early test termination in a German matrix speech test in noise in cochlear implant recipients.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-20 DOI: 10.1080/00016489.2025.2454479

Christoph Schmid, Martin Kompis, Wilhelm Wimmer

{"title":"Effects of early test termination in a German matrix speech test in noise in cochlear implant recipients.","authors":"Christoph Schmid, Martin Kompis, Wilhelm Wimmer","doi":"10.1080/00016489.2025.2454479","DOIUrl":"https://doi.org/10.1080/00016489.2025.2454479","url":null,"abstract":"Background: Speech reception thresholds (SRTs) can be estimated with speech in noise tests using adaptive procedures. Since these tests are time-consuming, it is preferable to use as few trials as possible to identify reliable results.Aims/objectives: To estimate the impact of early test termination in a German matrix speech test in noise (Oldenburger Satztest) on SRT estimation after 20 instead of after 30 sentences and to identify groups of subjects, for who such a tradeoff between measurement time and accuracy might be useful and acceptable.Material and methods: Retrospective analysis of 789 tests from cochlear implant users and from simulated tests in 10000 virtual subjects.Results: Early test termination results in increased estimation errors of the SRT in both real, and simulated listeners. Average test time is reduced from 5.0 to 3.6 min. For estimated SRT's above approximately +2 dB after 20 test sentences, the expected average difference to the result after 30 trials becomes higher than 0.5 dB.Conclusions and significance: If adaptive speech in noise tests are terminated already after 20 sentences, time can be saved, but it should be considered only in listeners with relatively favourable SRT-estimates after 20 trials, preferably below +2 dB.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparation on vestibular function during the perioperative period in pediatric cochlear implant patients with and without large vestibular aqueduct syndrome.

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-07 DOI: 10.1080/00016489.2024.2447046

Yanhong Li, Bing Liu, Yang Yang, Min Chen, Wei Liu, Ning Ma, Jie Zhang, Xin Ni

{"title":"Comparation on vestibular function during the perioperative period in pediatric cochlear implant patients with and without large vestibular aqueduct syndrome.","authors":"Yanhong Li, Bing Liu, Yang Yang, Min Chen, Wei Liu, Ning Ma, Jie Zhang, Xin Ni","doi":"10.1080/00016489.2024.2447046","DOIUrl":"https://doi.org/10.1080/00016489.2024.2447046","url":null,"abstract":"Backgrounds: It remains unclear whether LVAS pediatric patients experience more severe subjective symptoms after surgery compared to other pediatric patients, whether their objective vestibular function is worse, and the underlying reasons for their poorer subjective experience.Objectives: To compare vestibular function following CI between pediatric pediatric patients with and without LVAS.Materials and methods: The study included 11 patients in the LVAS group(18.42 ± 2.4 month) and 24 patients in the NLVAS group(35.73 ± 11.40 month). A comprehensive assessment of vestibular function was conducted both preoperatively and postoperatively. The assessment included vestibular function tests and evaluation of vestibular-related symptoms. The vestibular function test was conducted using cervical vestibular evoked myogenic potentials (cVEMP).Results: A higher incidence of postoperative dizziness was reported in the LVAS group compared to the NLVAS group (63.63% vs 0.08%, p = 0.001). The LVAS group exhibited a prolonged recovery period for head lifting and sitting compared to the NLVAS group (3.27 ± 0.715 vs 1.42 ± 0.119 days, p = 0.027; 4.09 ± 1.217 vs 1.92 ± 0.219 days, p = 0.022, respectively). The elicitation rate and amplitude of cVEMP in LVAS children showed no significant difference when compared to the NLVAS group preoperatively (p > 0.05). The LVAS group had a more decrease in amplitude 5 days after surgery compared to the NLVAS group (142.09 ± 33.98 vs 81.89 ± 17.13, p = 0.039).Conclusion: Pediatric patients with LVAS are more prone to experiencing dizziness symptoms post- CI surgery. There is an increased fluctuation in amplitude of cVEMP in LVAS pediatric patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Which is superior, the University of Pennsylvania Smell Identification Test or the threshold, Discrimination and Identification Test for testing human olfaction? A systematic review. 宾夕法尼亚大学嗅觉识别测试与阈值、辨别和识别测试在测试人类嗅觉方面孰优孰劣？系统综述。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-05 DOI: 10.1080/00016489.2025.2458170

Magne Bech, Kathrine Kronberg Jakobsen, Ida Schlosshauer Brandt Andersen, Christian Korsgaard Pedersen, Mathias Waldemar Grønlund, Christian von Buchwald

{"title":"Which is superior, the University of Pennsylvania Smell Identification Test or the threshold, Discrimination and Identification Test for testing human olfaction? A systematic review.","authors":"Magne Bech, Kathrine Kronberg Jakobsen, Ida Schlosshauer Brandt Andersen, Christian Korsgaard Pedersen, Mathias Waldemar Grønlund, Christian von Buchwald","doi":"10.1080/00016489.2025.2458170","DOIUrl":"https://doi.org/10.1080/00016489.2025.2458170","url":null,"abstract":"Background: The awareness and prevalence of olfactory dysfunction (OD) has increased significantly in recent years, with the SARS-CoV-2 pandemic being a major catalyzer. Consequently, demands for reliable OD tests have also risen.Aims: This systematic review compares two commonly used tests for olfactory assessment: the University of Pennsylvania Smell Identification Test (UPSIT) and the Threshold, Discrimination, and Identification test (TDI). The correlation between UPSIT, TDI, and the Visual Analogue Scale (VAS) for olfaction is also examined.Material and methods: A systematic search of PubMed and EMBASE identified articles validating UPSIT or TDI and comparing these to self-reported OD via VAS. The outcome of interest was test-retest validity and correlation.Results: The search identified 1536 studies, with nine meeting inclusion criteria. UPSIT showed a 'very strong' test-retest correlation, while TDI showed a 'strong' correlation. One study addressed VAS in relation to UPSIT and five for TDI. Correlation coefficients varied between VAS and TDI/UPSIT.Conclusions and significans: UPSIT and TDI exhibited strong to very strong test-retest reliability. Due to the limited number of studies, a meta-analysis was not feasible, and neither test was found to be superior in reliability. VAS did not correlate significantly with either TDI or UPSIT.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-4"},"PeriodicalIF":1.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0