Acta Oto-Laryngologica最新文献

{"title":"Nasopharyngeal neuroendocrine carcinoma: a population-based perspective.","authors":"Chuan Lu, Zhenchao Zhu, Ruikai Zhu, Chubo Xie, Qianhui Qiu","doi":"10.1080/00016489.2026.2673943","DOIUrl":"10.1080/00016489.2026.2673943","url":null,"abstract":"<p><strong>Background: </strong>Nasopharyngeal neuroendocrine carcinoma (NP-NEC) is a rare malignancy, and its clinical features, management, and prognosis remain poorly characterized.</p><p><strong>Objectives: </strong>To describe the clinicopathologic characteristics, treatment patterns, incidence, and survival of NP-NEC in a population-based cohort.</p><p><strong>Methods: </strong>Patients diagnosed with NP-NEC between 2000 and 2022 were identified from the Surveillance, Epidemiology, and End Results Program using ICD-O-3 topography. Demographic, tumor, and treatment data were extracted. Overall survival (OS) and disease-specific survival (DSS) were estimated using Kaplan-Meier methods and compared using log-rank tests.</p><p><strong>Results: </strong>The cohort comprised 96 patients, with a mean age of 56.98 years and a male predominance (68.8%). Small cell carcinoma was the predominant histologic subtype, accounting for 50% of cases. Most tumors were high-grade and advanced stage, and one-fifth of patients underwent surgery. Radiotherapy was delivered in 78.1%. Median OS and DSS were 21 and 23 months, with 5-year OS and DSS of 32.3% and 39.1%. Histologic subtype and AJCC stage were associated with both OS and DSS, and treatment modality was associated with DSS.</p><p><strong>Conclusions: </strong>NP-NEC is uncommon and carries a poor prognosis. Early-stage disease and carcinoid histology appear associated with favorable survival. Stage, histologic subtype, and definitive local therapy may be key determinants of outcome.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1144-1152"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Germany's role in global transoral robotic surgery research: a bibliometric analysis of national output, citation impact, and international collaboration (2015-2025).","authors":"Ulrich Hay, Stephan Lorenz, Helmut Steinhart, Adrian Hoenle","doi":"10.1080/00016489.2026.2674801","DOIUrl":"10.1080/00016489.2026.2674801","url":null,"abstract":"<p><strong>Background: </strong>Germany ranks among the highest-impact nations in global transoral robotic surgery (TORS) research, yet its national contribution, institutional landscape, and collaborative network structure have not been characterised through systematic bibliometric analysis.</p><p><strong>Aims/objectives: </strong>To quantify Germany's role within the global TORS literature, characterise its research concentration, compare its international collaboration rate and map its position within the global co-authorship network.</p><p><strong>Material and methods: </strong>Publications with German institutional affiliation were extracted from 9,382 TORS-related peer-reviewed papers retrieved from OpenAlex and Dimensions (2015-2025). National output, citation impact, research concentration (Lorenz curve; Gini coefficient), and international collaboration patterns were analysed using Bibliometrix (R), VOSviewer, and RStudio. Chi-square tests compared Germany's collaboration rate against leading nations.</p><p><strong>Results: </strong>Germany contributed 358 publications (5,092 citations; CPP = 14.2), ranking third globally by citation impact. An institutional Gini coefficient of 0.291 indicated moderate output concentration. Germany's international collaboration rate (24%) exceeded those of the USA (9%) and China (15%) (<i>p</i> < 0.001), while being indistinguishable from comparable European nations.</p><p><strong>Conclusions and significance: </strong>Germany embodies a quality-over-quantity research with a high citation impact and a distinctly European collaborative orientation. These findings provide the first evidence-based characterisation of Germany's scientific identity in global robotic head and neck surgery research.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1171-1177"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of postoperative complications and risk factors in middle ear surgery.","authors":"Yunfan Yin, Ling Ji, Yanrui Wang, Youmou Chen, Jin Li","doi":"10.1080/00016489.2026.2652349","DOIUrl":"10.1080/00016489.2026.2652349","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Postoperative complications following middle ear surgery present ongoing challenges despite advances in surgical techniques. A comprehensive analysis of complication patterns, associated risk factors, and their interactions with patient comorbidities is needed to improve patient safety and outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To analyze the incidence, patterns, and risk factors of postoperative complications following middle ear surgery, and to develop a predictive model for complication risk assessment incorporating patient demographics, comorbid conditions, surgical variables, and surgeon experience.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Material and methods: &lt;/strong&gt;This single-center retrospective cohort study analyzed 200 patients who underwent middle ear surgery between January 2018 and December 2024. Data were collected on demographics (including body mass index and smoking status), comorbidities (hypertension, diabetes mellitus), preoperative conditions, surgical procedures, surgeon experience, and postoperative complications. Risk factors were identified using univariate and multivariate logistic regression analyses. Severity of facial nerve palsy was graded using the House-Brackmann scale, and sensorineural hearing loss was classified as mild, moderate, or severe.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 45 patients (22.5%) experienced at least one postoperative complication, yielding 53 complication events (eight patients experienced multiple complications). Early complications (&lt;30 days) occurred in 33 patients (16.5%) and late complications (≥30 days) in 12 patients (6.0%). The most common complications were sensorineural hearing loss (8.5%; mild in 9, moderate in 5, severe in 3), facial nerve paresis (4.5%; all delayed onset; House-Brackmann Grade II in 4, Grade III in 3, Grade IV in 2), surgical site infection (4.0%), and CSF leak (2.5%). Multivariate analysis identified cholesteatoma (OR = 3.24, 95% CI: 1.68-6.25, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), surgical duration &gt;180 min (OR = 2.87, 95% CI: 1.42-5.79, &lt;i&gt;p&lt;/i&gt; = 0.003), revision surgery (OR = 2.45, 95% CI: 1.23-4.88, &lt;i&gt;p&lt;/i&gt; = 0.011), and age ≥60 years (OR = 2.12, 95% CI: 1.08-4.17, &lt;i&gt;p&lt;/i&gt; = 0.029) as independent risk factors. Body mass index, smoking status, and comorbidities (hypertension, diabetes mellitus) were analyzed but did not reach statistical significance in multivariate analysis. Surgeon experience (≤5 years) was associated with higher complication rates on univariate analysis (31.8% vs. 17.9%, &lt;i&gt;p&lt;/i&gt; = 0.028) but was not retained in the final multivariate model. The predictive model showed good discrimination (AUC = 0.812, 95% CI: 0.751-0.873) with an events-per-variable ratio of 11.25.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and significance: &lt;/strong&gt;Postoperative complications remain significant in middle ear surgery, with cholesteatoma, prolonged surgery, revision procedures, and advanced age as key risk factors. The developed predictive model can aid in preoperativ","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1055-1066"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paucity of type 2 cytokines and atypical IL-5 receptor alpha patterns during established eosinophilic inflammation in seasonal allergic rhinitis.","authors":"Franziska U Nordström, Christina Sakellariou, Caroline Lindö, Premkumar Siddhuraj, Jimmie Jönsson, Johan Ahlgren, Cecilia K Andersson, Caroline Sandén, Malin Lindstedt, Lennart Greiff, Jonas S Erjefält","doi":"10.1080/00016489.2026.2670715","DOIUrl":"10.1080/00016489.2026.2670715","url":null,"abstract":"<p><strong>Background: </strong>Seasonal allergic rhinitis (SAR) is viewed as a type 2 (T2) disease driven by the IL-5/IL-5 receptor α (IL-5Rα) and IL-4/IL-13/IL-4 receptor (IL-4R) pathways and the upstream epithelial alarmins IL-33 and TSLP. However, the dynamics and expression patterns of T2-immunity in the nasal mucosa during sustained allergen exposure remain poorly understood.</p><p><strong>Aim/objective: </strong>To investigate whether traditional T2-cytokine and alarmin expressions persist during sustained, well-developed eosinophilic inflammation in patients with SAR.</p><p><strong>Methods: </strong>Twenty patients were examined late in and outside the birch pollen season. Symptoms, blood, nasal secretions, and mucosal biopsies were evaluated. Analyses included multiplex immunohistochemistry, <i>in situ</i> hybridisation, and computerized image analysis to quantify immune cells, cytokine/alarmin-expression, and their receptors, focusing on IL-5Rα.</p><p><strong>Results: </strong>Late in the season, patients presented increased symptoms, blood/tissue eosinophilia, and elevated basophils, mast cells, and T helper 2 cells, consistent with a T2-phenotype. Unexpectedly, cells expressing IL-4 and IL-5 mRNA were undetectable. Surprisingly, IL-5Rα was abundant on epithelial cells, but not on mucosal eosinophils. Few scattered IL-13^HIGH cells were identified. IL-33 expression remained robust but was lower compared with post-seasonal observations.</p><p><strong>Conclusions and significance: </strong>Sustained eosinophilic inflammation in SAR may be maintained by non-T2-pathways in established allergic disease, potentially informing future treatment strategies.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1118-1130"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enlarged vestibular aqueduct concomitant with endolymphatic hydrops.","authors":"Po-Yu Chen, Yu-Fen Wang, Yi-Ho Young","doi":"10.1080/00016489.2026.2668688","DOIUrl":"10.1080/00016489.2026.2668688","url":null,"abstract":"<p><strong>Background: </strong>Enlarged vestibular aqueduct (EVA) is one of the most common inner ear anomalies associated with sensorineural hearing loss (SNHL) in childhood.</p><p><strong>Objective: </strong>This study aimed to investigate the prevalence of EH in patients with large vestibular aqueduct syndrome (LVAS).</p><p><strong>Methods: </strong>A total of 20 patients with congenital SNHL underwent an inner ear test battery aligned with Hydrops MRI. Among them, 7 patients (unilateral involvement in 2 and bilateral involvement in 5, totaling 12 ears) with LVAS were enrolled.</p><p><strong>Results: </strong>Abnormality rates across the inner ear test battery showed a significantly decreasing order, moving from audiometry (100%), cervical vestibular-evoked myogenic potential (VEMP) test (92%), caloric test (67%), to the ocular VEMP test (58%), which did not parallel with the declining trend of abnormality rate in Meniere's disease. Hydrops MRI demonstrated EH in 4 (57%) of 7 LVAS patients, comprising 5 ears in the cochlea and 4 ears in the vestibule. All patients received supportive treatment except one patient who underwent sac and shunt surgery, which resulted in profound deafness and recurrent postoperative vertigo.</p><p><strong>Conclusion: </strong>Hydrops MRI enables the simultaneous identification of EVA and EH. In this study, 57% of LVAS patients were found to have concomitant EH.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1105-1111"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration of neuromuscular blockade following standard induction dose of rocuronium in parotid surgery: a retrospective observational study.","authors":"Masaaki Higashino, Ryo Kawata, Yusuke Kikuoka, Ichita Kinoshita, Tsuyoshi Jinnin, Takeshi Tochizawa, Tetsuya Terada, Shin-Ichi Haginomori","doi":"10.1080/00016489.2026.2673945","DOIUrl":"10.1080/00016489.2026.2673945","url":null,"abstract":"<p><strong>Background: </strong>Due to the effects of NMBA administered during induction, intraoperative nerve monitoring may not respond properly during parotid gland surgery.</p><p><strong>Objective: </strong>To investigate the relationship between NMBA administration during anesthesia induction and the time to recovery for intraoperative nerve monitoring in parotid gland surgery.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed the medical records of 190 patients who underwent surgery for benign parotid tumors. We examined the factors associated with prolonged neuromuscular blockade. The correlation between NMBA dose per body weight and time to TOFC = 4 was also examined.</p><p><strong>Results: </strong>The incidence of TOFC = 4 was 5.3% at 20 min, 33.2% at 40 min, 73.1% at 60 min, 91.6% at 80 min, and 96.3% at 100 min after NMBA administration. The time to TOFC = 4 was prolonged with a higher rocuronium dose per body weight, older age, and reduced renal function, each being an independent factor. A positive correlation was observed between NMBA dose and time to TOFC = 4. The administering rocuronium at 0.6 mg/kg during induction resulted in a TOFC = 4 time of 51.5 min.</p><p><strong>Conclusion: </strong>In parotid gland surgery, the effects of NMBAs used during induction may persist in some cases.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1153-1161"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148051889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical injuries and underlying factors in novice's mastoidectomy and posterior tympanotomy training.","authors":"Jesse Tapiala, Aarno Dietz, Tomi Timonen, Hana Vrzáková, Matti Iso-Mustajärvi","doi":"10.1080/00016489.2026.2661770","DOIUrl":"10.1080/00016489.2026.2661770","url":null,"abstract":"<p><strong>Background: </strong>Achieving surgical expertise requires repetition and continuous practice. As clinical demands increase and opportunities for safe learning decline, enhancing surgical training methods is essential.</p><p><strong>Purpose: </strong>In this study, we investigate what kind of errors beginners make during mastoidectomy and posterior tympanotomy and what factors precede those injuries.</p><p><strong>Materials and methods: </strong>We analyzed video recordings of 30 medical students performing mastoidectomy and posterior tympanotomy on 3D-printed temporal bone models. The participants were trained using either traditional methods or VR. We assessed surgical injuries and their possible underlying causes by analyzing the end result and video recordings.</p><p><strong>Results: </strong>The most common surgical errors were injuries to the posterior ligament of the incus, posterior ear canal wall, and incus body in 64%, 27%, and 13% of the models, respectively. Common factors included insufficient anatomical knowledge, inadequate exposure, poor spatial orientation, and inattention to nearby anatomical features during targeted work.</p><p><strong>Conclusions and significance: </strong>Novice surgeons commonly make errors which differ from previously reported error-rates for experienced surgeons. These data could be useful to better understand what novices are struggling with when developing surgical training methods in the future.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1067-1074"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute otitis media in children: molecular genetics approach (rs1061581), clinical and micro-social predictors (single-center cross-sectional case-control study).","authors":"Larysa Sydorchuk, Oleksii Sakovets, Andrii Sydorchuk, Iryna Batih, Sai Praveen Daruvuri, Ruslan Sydorchuk","doi":"10.1080/00016489.2026.2674799","DOIUrl":"10.1080/00016489.2026.2674799","url":null,"abstract":"<p><strong>Background: </strong>Acute otitis media (AOM) is the 2^nd most frequent ENT diagnosis in early childhood.</p><p><strong>Objective: </strong>The aim of the study was to evaluate the clinical, anamnestic and micro-social predictors of AOM in children and its association with heat-shock protein gene (HSP70-2, rs1061581) polymorphism.</p><p><strong>Material and methods: </strong>A total of 95 children with AOM (7-18 years old) participated in the study. HSP70-2 (rs1061581) gene genotyping was performed by qPCR method. Risk factors were analyzed.</p><p><strong>Results: </strong>The A-allele of the HSP70-2 gene is a predictor of a more severe AOM course in children and increases its risk and purulent ear discharge almost 2.5 times (<i>p</i> < 0.05), otorrhea - twofold. In preadolescence chronic hypertrophic or vasomotor rhinitis, adenoid vegetations of II-III degrees and non-obstructive diseases of the lower respiratory tract cause an AOM increase risk 3-6 times (<i>p</i> < 0.05). In adolescence, the probability of AOM increases with chronic persistence of hemolytic streptococcus in the oropharynx and broncho-obstructive diseases almost 10 times (<i>p</i> < 0.05). Early daycare attendance before the age of 3 elevates AOM likelihood more than 3 times (<i>p</i> = 0.001).</p><p><strong>Conclusion and significance: </strong>Clinical and social predictors affect the severity of AOM in children depending on age. A-allele (rs1061581) associates with a more severe AOM course in children.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1162-1170"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Vestibulo-Ocular reflex in polycystic Ovary Syndrome: a Case-Control study using video head impulse testing.","authors":"Asuman Küçüköner, Emel Tahir, Ulaş Çoban, Ayşe Zehra Özdemir","doi":"10.1080/00016489.2026.2677603","DOIUrl":"10.1080/00016489.2026.2677603","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a common endocrine disorder that may affect multiple organ systems. While cochlear and otolith involvement has been investigated, the impact on semicircular canal-mediated vestibulo-ocular reflex (VOR) function remains unclear.</p><p><strong>Aims/objectives: </strong>To evaluate canal-specific, high-frequency VOR function in women with PCOS using the video head impulse test (vHIT) and compare findings with healthy controls.</p><p><strong>Material and methods: </strong>This single-center case-control study included 42 women with PCOS (Rotterdam criteria) and 35 age-matched controls. vHIT was performed using the Interacoustics EyeSeeCam system. Canal-specific VOR gains, asymmetry indices (LARP, RALP, lateral), and corrective saccade frequencies were analyzed.</p><p><strong>Results: </strong>After correction for multiple comparisons (Benjamini-Hochberg method), LARP asymmetry was the only parameter that remained statistically significant in PCOS (<i>p</i> = 0.002; <i>p</i> = 0.019). Unadjusted differences in left lateral and right posterior canal gains did not survive correction. Corrective saccade frequency did not differ between groups.</p><p><strong>Conclusions and significance: </strong>Women with PCOS exhibited subtle, canal-specific differences in high-frequency VOR function. However, these findings should be interpreted cautiously, and their clinical significance remains uncertain.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1178-1184"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148142369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of endolymphatic sac surgery for lermoyez syndrome: a 2-year and 10-year follow-up.","authors":"Jiahua Luo, Lin Han, Yatong Zhang, Lisheng Yu, Yixu Wang","doi":"10.1080/00016489.2026.2667877","DOIUrl":"10.1080/00016489.2026.2667877","url":null,"abstract":"<p><strong>Background: </strong>Lermoyez syndrome (LS) is a rare auditory disorder, and its treatment is empirical. The efficacy of endolymphatic sac surgery for LS remains unknown.</p><p><strong>Objectives: </strong>To assess short- and long-term outcomes of endolymphatic sac surgery (ELS) in Lermoyez syndrome (LS).</p><p><strong>Material and methods: </strong>Retrospective analysis of 19 patients with refractory LS from a tertiary hospital in China. The primary outcome was change in vertigo attack frequency over 6 months at 2- and 10-year follow-ups compared with the 6 months preoperatively. Hearing outcomes and predictors of improvement were evaluated.</p><p><strong>Results: </strong>Mean vertigo attacks decreased from 2.28 ± 3.92 per 6 months preoperatively to 1.04 ± 2.77 at 2 years and 0.90 ± 1.24 at 10 years, indicating a significant reduction (<i>p</i> = 0.036). Age was negatively associated with hearing improvement at both follow-ups. At 10 years, higher LS stage predicted poorer hearing improvement (β = -4.56; 95% CI -8.65 to -0.48; <i>p</i> = 0.029). All patients tolerated endolymphatic sac surgery well.</p><p><strong>Conclusions and significance: </strong>ELS is a safe, effective option for refractory LS, providing durable vertigo control and helping prevent further hearing deterioration. Efficacy diminishes with advancing stage, supporting earlier surgical intervention to maximize hearing preservation.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1090-1095"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}