Acta Oto-LaryngologicaPub Date : 2025-06-01Epub Date: 2025-04-08DOI: 10.1080/00016489.2025.2476188
Emma M Teunissen, Tjerk W Aukema, Coosje J I Caspers, Kim H E Bakkum, Ivo J Kruyt, Froukje L J Cals, Emmanuel A M Mylanus, Myrthe K S Hol
{"title":"Single-stage bone-anchored hearing implant surgery in children: a prospective comparative study.","authors":"Emma M Teunissen, Tjerk W Aukema, Coosje J I Caspers, Kim H E Bakkum, Ivo J Kruyt, Froukje L J Cals, Emmanuel A M Mylanus, Myrthe K S Hol","doi":"10.1080/00016489.2025.2476188","DOIUrl":"10.1080/00016489.2025.2476188","url":null,"abstract":"","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"491-498"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clara H Pinborg, Amanda-Louise F Carlander, Joachim Hansen, Christian Grønhøj, Kathrine K Jakobsen, Christian von Buchwald
{"title":"Prognostic impact of p16 and HPV discordance in cancer of unknown primary: a systematic review and meta-analysis.","authors":"Clara H Pinborg, Amanda-Louise F Carlander, Joachim Hansen, Christian Grønhøj, Kathrine K Jakobsen, Christian von Buchwald","doi":"10.1080/00016489.2025.2509655","DOIUrl":"https://doi.org/10.1080/00016489.2025.2509655","url":null,"abstract":"<p><strong>Background: </strong>Discordance between human papillomavirus (HPV) and its surrogate marker, p16INK4a (p16), raises concerns about the reliability of p16 as a sole prognostic marker.</p><p><strong>Objectives: </strong>To investigate the impact of HPV, p16, and discordant HPV/p16 status on survival in squamous cell carcinoma of unknown primary in the head and neck (SCCUPHN).</p><p><strong>Materials and methods: </strong>PubMed and EMBASE were searched for relevant studies that used a strict definition of SCCUPHN and reported survival outcomes stratified by HPV/p16 status. A meta-analysis assessed the prevalence and overall survival (OS).</p><p><strong>Results: </strong>Twelve studies (<i>n</i> = 864) were included. The pooled prevalence rates were: 23% HPV+/p16+ SCCUPHN (95% CI: 14-33%); 50% HPV-/p16- (95% CI: 32-67%); 13% HPV-/p16+ (95% CI: 6-19%); and 6% HPV+/p16- (95% CI: 1-10%). OS hazard ratios were: 0.37 (95% CI: 0.17-0.78) for p16+ vs. p16-, 0.35 (95% CI: 0.19-0.64) for HPV+ vs. HPV-, and 0.24 (95% CI: 0.12-0.50) for HPV+/p16+ vs. HPV-/p16-. Only one study (<i>n</i> = 103) compared survival in the four HPV/p16 subgroups individually.</p><p><strong>Conclusions: </strong>HPV and p16 are individual positive prognostic markers in SCCUPHN. Although significant discordance exists, the current literature does not provide sufficient evidence to support risk stratifying SCCUPHN patients into four distinct HPV/p16 subgroups.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between mastoid pneumatization and antrochoanal polyps in pediatric patients.","authors":"Gamze Ozturk Yilmaz, Gokhan Yilmaz, Nevfel Kahvecioglu, Erdem Atalay Cetinkaya, Omer Tarik Selcuk, Ozer Erdem Gur, Hulya Eyigor","doi":"10.1080/00016489.2025.2510503","DOIUrl":"https://doi.org/10.1080/00016489.2025.2510503","url":null,"abstract":"<p><strong>Background: </strong>Mastoid pneumatization reflects middle ear aeration and may be disrupted in chronic inflammatory conditions such as Antrochoanal polyps (AP), potentially predisposing children to otologic complications.</p><p><strong>Objective: </strong>We aimed to investigate the developmental relationship between AP volume and total mastoid air cell volume (TMCV).</p><p><strong>Methods: </strong>The correlation between the volume of nasal polyps and TMCV was assessed in 21 pediatric patients with AP. TMCV on the side not affected by AP served as the control within each patient. Polyp volume and TMCV were quantified using computed tomography (CT)-based 3D reconstruction.</p><p><strong>Results: </strong>The mean TMCV on the side with AP was 7.68 ± 6.13 cm³, while the mean TMCV on the contralateral side was 8.44 ± 6.67 cm³. This difference was statistically significant (<i>p</i> = 0.042). However, no statistically significant correlation was observed between polyp volume and TMCV on the affected side (<i>p</i> = 0.758).</p><p><strong>Conclusion: </strong>Our results suggest that AP may have a negative effect on mastoid pneumatization. Further research with larger cohorts is warranted.</p><p><strong>Significance: </strong>These findings highlight the need for comprehensive radiologic evaluation in children with AP to monitor potential mastoid involvement.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-4"},"PeriodicalIF":1.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Na Zhang, Xiaobo Ma, Danni Wang, Yi Li, Yan Zheng, Yongxin Li, Shouqin Zhao
{"title":"Impact of age on hearing outcomes following stapes surgery for otosclerosis: a retrospective study.","authors":"Na Zhang, Xiaobo Ma, Danni Wang, Yi Li, Yan Zheng, Yongxin Li, Shouqin Zhao","doi":"10.1080/00016489.2025.2504040","DOIUrl":"https://doi.org/10.1080/00016489.2025.2504040","url":null,"abstract":"<p><strong>Background: </strong>Otosclerosis causes progressive hearing loss, with stapes surgery being the most effective treatment. However, the influence of age on postoperative outcomes remains debated.</p><p><strong>Objective: </strong>To evaluate the impact of age on hearing outcomes following stapes surgery.</p><p><strong>Methods: </strong>This retrospective study included patients who underwent primary stapes surgery (2010-2024), excluding those with revision surgeries or confirmed cochlear otosclerosis. Pre- and postoperative pure-tone audiometry assessed air conduction (AC), bone conduction (BC), and air-bone gap (ABG) across age groups.</p><p><strong>Results: </strong>This study included 177 patients (188 ears) aged 18-68 years. Significant improvements in AC thresholds and ABG closure were observed across all age groups (<i>p</i> < 0.05). BC thresholds improved significantly in patients <50 years. Linear regression revealed a modest negative correlation between age and AC improvement (<i>R</i><sup>2</sup> = 0.18, <i>p</i> = 0.006). Despite smaller gains in older patients, both age groups demonstrated substantial improvements AC thresholds and ABG, with minimal changes in BC thresholds. No significant differences were found between younger and older groups in changes in BC, AC, or ABG closure (all <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Stapes surgery significantly improves hearing outcomes across all ages, especially in AC thresholds and ABG closure. Age should not be a contraindication if audiological criteria are met.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of vestibular rehabilitation in patients with residual dizziness after treatment for benign paroxysmal positional vertigo.","authors":"Tomoyuki Shiozaki, Masaharu Sakagami, Tadao Okayasu, Takao Imai, Tadashi Kitahara","doi":"10.1080/00016489.2025.2506671","DOIUrl":"https://doi.org/10.1080/00016489.2025.2506671","url":null,"abstract":"<p><strong>Background: </strong>Benign paroxysmal positional vertigo (BPPV) is a prevalent cause of vertigo. Although canalith repositioning procedures are effective, some patients continue to experience residual dizziness (RD) and balance disturbances that adversely affect daily activities.</p><p><strong>Aims/objectives: </strong>This study aimed to assess the impact of vestibular rehabilitation on patients with RD following BPPV treatment.</p><p><strong>Material and methods: </strong>Thirty participants were allocated into two groups: a rehabilitation group (Group 1) that received weekly physiotherapy and performed home exercises for six months and an aerobic exercise instruction group (Group 2) that attended bi-monthly sessions. Outcome measures included the modified Dizziness Handicap Inventory (mDHI), posturography, Functional Gait Assessment (FGA), and Self-rating Depression Scale (SDS).</p><p><strong>Results: </strong>Both groups demonstrated significant improvements in mDHI and FGA scores pre- and post-intervention. However, only Group 1 exhibited a significant improvement in centre of pressure movement with eyes closed (COP EC) after the intervention. When comparing the two groups, post-intervention mDHI and COP EC scores showed significantly greater improvement in Group 1.</p><p><strong>Conclusions and significance: </strong>These findings suggest that vestibular rehabilitation may enhance dizziness resolution and postural control in patients with RD.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Louise Devantier, Henriette Edemann Callesen, Dan Dupont Hougaard, Bjarki Ditlev Djurhuus, Frank Liviu-Adelin Guldfred, Jesper Hvass Schmidt
{"title":"A systematic review and meta-analysis of intratympanic gentamicin for patients with Ménières disease.","authors":"Louise Devantier, Henriette Edemann Callesen, Dan Dupont Hougaard, Bjarki Ditlev Djurhuus, Frank Liviu-Adelin Guldfred, Jesper Hvass Schmidt","doi":"10.1080/00016489.2025.2504033","DOIUrl":"https://doi.org/10.1080/00016489.2025.2504033","url":null,"abstract":"<p><strong>Background: </strong>Ménière's disease is a chronic inner ear disorder characterized by recurrent vertigo, tinnitus, aural fullness, and fluctuating sensorineural hearing loss. For patients with debilitating symptoms unresponsive to conservative treatment, intratympanic gentamicin is a therapeutic option. However, its efficacy and safety remain uncertain.</p><p><strong>Aims/objectives: </strong>This systematic review aims to evaluate the effectiveness and safety of intratympanic gentamicin in Ménière's disease, focusing exclusively on randomized controlled trials (RCTs).</p><p><strong>Material and methods: </strong>A comprehensive literature search was conducted to identify RCTs comparing intratympanic gentamicin with placebo or no treatment. Primary outcomes included vertigo frequency and severity, quality of life, and incidence of serious adverse events. Data were analyzed using the GRADE approach to assess risk of bias and certainty of evidence.</p><p><strong>Results: </strong>Three RCTs were included, demonstrating a significant reduction in vertigo frequency and severity in patients treated with intratympanic gentamicin compared to placebo. However, the evidence quality was rated very low due to small sample sizes and methodological limitations.</p><p><strong>Conclusions and significance: </strong>Findings suggest that intratympanic gentamicin may reduce vertigo in Ménière's disease. However, due to the limited certainty of the evidence, further research with larger sample sizes and standardized outcome measures is necessary to clarify its benefits and risks.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jenna Felder, Karin A Koinig, Ilona Anderson, Angelika Illg, Mareike Billinger-Finke
{"title":"Validation and psychometric properties of the quality of life in people with hearing loss questionnaire (HL-QoL) in English.","authors":"Jenna Felder, Karin A Koinig, Ilona Anderson, Angelika Illg, Mareike Billinger-Finke","doi":"10.1080/00016489.2025.2504636","DOIUrl":"https://doi.org/10.1080/00016489.2025.2504636","url":null,"abstract":"<p><strong>Background: </strong>The Quality of Life in People with Hearing Loss Questionnaire (HL-QoL) measures quality of life (QoL) in individuals with hearing loss. The German version of the HL-QoL was validated in cochlear implant (CI) users.</p><p><strong>Objectives: </strong>Validation of the English version of the HL-QoL.</p><p><strong>Material and methods: </strong>The HL-QoL was forward-backward translated. 97 participants were included in the HL-QoL validation. Item and scale analyses assessed the quality of individual items and of the questionnaire in its entirety.</p><p><strong>Results: </strong>Questionnaire validation results confirmed item difficulty and item discrimination, good test reliability and construct and discriminant validity. The mean total HL-QoL score was 103 points, which indicates a 'high' quality of life. 94% of participants reported at least a 'moderate' quality of life benefit. Participants tended to have a higher QoL when their hearing loss was fully addressed, i.e. biltaral CI users with bilateral hearing loss. QoL did not correlate with age, duration of CI use, sex, or gender.</p><p><strong>Conclusion: </strong>The English version of the HL-QoL is a valid tool to assess how hearing loss and its treatment can impact an individual's quality of life. The mean total HL-QoL score suggests an overall high QoL benefit in this sample of CI users.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"β-catenin expression as a strong predictor of recurrence in juvenile angiofibroma.","authors":"Marlinda Adham, Regina Talitha Rosa, Alok Thakar, Lisnawati Rachmadi, Indrati Suroyo, Joedo Prihartono","doi":"10.1080/00016489.2025.2504635","DOIUrl":"https://doi.org/10.1080/00016489.2025.2504635","url":null,"abstract":"<p><strong>Background: </strong>Juvenile angiofibroma (JA) is a rare fibrovascular tumor affecting young males. Although histologically benign, JA is clinically aggressive, with high morbidity, mortality, and recurrence rates. While β-catenin expression is known to contribute to JA growth, its role in recurrence remains uncertain.</p><p><strong>Objective: </strong>This study investigates the relationship between β-catenin expression and recurrence risk in JA patients.</p><p><strong>Method: </strong>An analytical observational case-control study was conducted at Dr. Cipto Mangunkusumo Hospital, analyzing 33 JA patients who underwent tumor excision (2013-2022). Patients without recurrence were controls, while those with recurrence were cases. Immunohistochemistry and H-scoring quantified β-catenin expression, and statistical analysis examined its association with recurrence. ROC curves determined cut-off values.</p><p><strong>Results: </strong>Among 33 patients (all male, aged 9-28 years; mean: 16.2 years), 15 had recurrences. High β-catenin expression was significantly associated with recurrence (<i>p</i> = 0.000), with an H-score cut-off of 124.2 (100% sensitivity/specificity). Age ≤18 years correlated with higher recurrence risk (<i>p</i> < .05; OR 8.9). Tumor size, volume, stage, pre-extirpation procedures, surgical techniques, and intraoperative blood loss had no significant effect.</p><p><strong>Conclusion: </strong>High β-catenin expression is a strong predictor of JA recurrence, suggesting its potential as a prognostic marker. Targeting β-catenin pathways may aid in recurrence prevention and improved JA management.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erim Pamuk, Yaşar Enez Bilen, Çağrı Külekçi, Oğuz Kuşcu
{"title":"ChatGPT-4 vs. multi-disciplinary tumor board decisions for the therapeutic management of primary laryngeal cancer.","authors":"Erim Pamuk, Yaşar Enez Bilen, Çağrı Külekçi, Oğuz Kuşcu","doi":"10.1080/00016489.2025.2502563","DOIUrl":"https://doi.org/10.1080/00016489.2025.2502563","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence-based clinical decision support systems are promising tools for addressing the increasing complexity of oncological data and treatment. However, the integration and validation of models such as ChatGPT within multidisciplinary decision-making processes for head and neck cancers remain limited.</p><p><strong>Objective: </strong>To evaluate the performance of ChatGPT-4 in the management of primary laryngeal cancer and compare it with multidisciplinary tumor board (MDT) decisions.</p><p><strong>Methods: </strong>The medical records of 25 patients with untreated laryngeal cancer were evaluated using ChatGPT-4 for therapeutic recommendations. The coherence of responses was graded from Grade 1 (totally coherent) to Grade 4 (totally incoherent) and compared with actual MDT decisions. The association between patient features and response grades was also assessed.</p><p><strong>Results: </strong>ChatGPT-4 provided totally coherent (Grade 1) responses consistent with MDT decisions in 72% of the patients. The rates of Grade 2 and Grade 3 coherent responses were 20% and 8%, respectively. There were no totally incoherent responses. There was no significant association between the grade of coherence and T stage, N stage, tumor localization, differentiation, or age (<i>p</i> = 0.106, <i>p</i> = 0.588, <i>p</i> = 0.271, <i>p</i> = 0.677, <i>p</i> = 0.506, respectively).</p><p><strong>Conclusion: </strong>With further improvements, ChatGPT-4 can be a promising adjunct tool for clinicians in decision-making for primary laryngeal cancer.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anders Erlandsson, Martin Lundahl, Anna Holm, Katarina Olofsson
{"title":"A descriptive study on laryngotracheal stenosis in the Northern Sweden.","authors":"Anders Erlandsson, Martin Lundahl, Anna Holm, Katarina Olofsson","doi":"10.1080/00016489.2025.2503000","DOIUrl":"https://doi.org/10.1080/00016489.2025.2503000","url":null,"abstract":"<p><strong>Background: </strong>We have in a retrospective design used laryngotracheal stenosis (LTS) classification to describe stenotic subsites and through international classification of disease (ICD-10) codes its diagnostic origins. The diagnostic challenge posed by varied etiologies can lead to treatment delays, in potentially life-threatening conditions.</p><p><strong>Aims/objectives: </strong>The purpose of this study is to explore and ascertain the etiological and anatomical distribution of LTS to reduce misdiagnosis and as such delayed access to adequate treatment.</p><p><strong>Material and methods: </strong>The included cases were consecutively recruited between 1999 and 2019, all labeled with relevant ICD-10 codes for the research question in combination with medical records for evaluation of its accuracy. The primary outcome was the causes, and anatomical locations of LTS.</p><p><strong>Results: </strong>A total of 1441 records were screened, with 1071 cases meeting the inclusion criteria. The most common cause was unilateral vocal fold immobility, followed by glottic cancer. Benign causes were more prevalent than malignant ones, with glottic-level stenoses being most frequent.</p><p><strong>Conclusion and significance: </strong>Unilateral vocal fold immobility is the most prevalent cause of LTS in our material. These findings can enhance diagnostic efficiency by increasing clinical awareness of common etiologies.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}