Acta Oto-Laryngologica最新文献

{"title":"The association of sex steroid hormone concentrations with hearing loss: a cross-sectional study.","authors":"Huifen Yang, Jing Li, Xinyuan Sun, Wangwei Li, Yuan Wang, Caiqin Huang","doi":"10.1080/00016489.2023.2224398","DOIUrl":"10.1080/00016489.2023.2224398","url":null,"abstract":"Abstract Background Hearing loss is the most prevalent sensory disorder worldwide. Several studies have indicated that sex steroid hormone levels may be vital to hearing. Objective We aimed to explore the associations between speech-frequency hearing loss and sex steroid hormones. Methods We conducted a secondary analysis based on 3558 adult participants’ data from the National Health and Nutrition Examination Survey (NHANES) from 2015 to 2016. We defined hearing loss as a pure-tone average (PTA) at 0.5, 1, 2, and 4 kHz ≥20 dB in the better ear. Multivariate logistic regression analysis was used to evaluate the association between sex steroid hormones and hearing loss risk. A nomogram model for the risk of hearing loss was constructed. Results There were 560 (15.7%) cases who had hearing loss among the participants enrolled in this study. Participants with hearing loss had a higher total testosterone level and a lower estradiol level. Individuals with estradiol levels in the highest tertile still had lower hearing loss risks than those in the lowest tertile. Nevertheless, the total testosterone level had no influence on the risk of hearing loss. Conclusion Our research indicated that low estradiol concentrations were significantly associated with hearing loss, especially in menopausal women.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 7","pages":"582-588"},"PeriodicalIF":1.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10086572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of middle ear structure and function with optical coherence tomography.","authors":"Sebastiaan W F Meenderink, Michael Warn, Laura M Anchondo, Yuan Liu, Timothy T K Jung, Wei Dong","doi":"10.1080/00016489.2023.2224846","DOIUrl":"10.1080/00016489.2023.2224846","url":null,"abstract":"<p><strong>Background: </strong>Current clinical tests for middle ear (ME) injuries and related conductive hearing loss (CHL) are lengthy and costly, lacking the ability to noninvasively evaluate both structure and function in real time. Optical coherence tomography (OCT) provides both, but its application to the audiological clinic is currently limited.</p><p><strong>Objective: </strong>Adapt and use a commercial Spectral-Domain OCT (SD-OCT) to evaluate anatomy and sound-evoked vibrations of the tympanic membrane (TM) and ossicles in the human ME.</p><p><strong>Materials and methods: </strong>SD-OCT was used to capture high-resolution three-dimensional (3D) ME images and measure sound-induced vibrations of the TM and ossicles in fresh human temporal bones.</p><p><strong>Results: </strong>The 3D images provided thickness maps of the TM. The system was, with some software adaptations, also capable of phase-sensitive vibrometry. Measurements revealed several modes of TM vibration that became more complex with frequency. Vibrations were also measured from the incus, through the TM. This quantified ME sound transmission, which is the essential measure to assess CHL.</p><p><strong>Conclusion and significance: </strong>We adapted a commercial SD-OCT to visualize the anatomy and function of the human ME. OCT has the potential to revolutionize point-of-care assessment of ME disruptions that lead to CHL which are otherwise indistinguishable via otoscopy.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 7","pages":"558-562"},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High rate of early recurrence of peritonsillar abscess among adolescents and young adults.","authors":"Martin Agerhäll,&nbsp;Sandra Larsson,&nbsp;Krister Tano,&nbsp;Diana Berggren","doi":"10.1080/00016489.2023.2225555","DOIUrl":"10.1080/00016489.2023.2225555","url":null,"abstract":"<p><strong>Background: </strong>Peritonsillar abscess (PTA) can be treated with aspiration or incision for drainage, but a subsequent PTA can occur if tonsillectomy is not performed. Better understanding is needed of when tonsillectomy should be performed to avoid PTA recurrence.</p><p><strong>Objective: </strong>This study investigated the recurrence rate of PTA following aspiration or incision for drainage and evaluated the risk factors for recurrence.</p><p><strong>Methods: </strong>The medical records of 292 patients treated for PTA were reviewed. Recurrence of PTA and elective or quinsy tonsillectomy were the primary endpoints. A Cox proportional hazards regression model for PTA recurrence was constructed with sex, age, and PTA history as predictors.</p><p><strong>Results: </strong>Young age was the only significant predictor of PTA recurrence. Patients aged 15 to 24 years had a 30-day recurrence rate of 15.5% and a total recurrence rate of 26.6%. The total recurrence rate among patients over 30 years of age was significantly less at 4.0% (Fisher's exact test, <i>p</i> < .05).</p><p><strong>Conclusion and significance: </strong>Based on our results, tonsillectomy should be considered for PTA patients between 15 and 25 years of age and, to effectively avoid future recurrence of PTA, should be performed urgently.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 7","pages":"602-605"},"PeriodicalIF":1.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10405155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype-phenotype associations in paragangliomas of the temporal bone in a multi-ethnic cohort.","authors":"Simon I Angeli,&nbsp;Juan A Chiossone K,&nbsp;Stefania Goncalves,&nbsp;Fred F Telischi","doi":"10.1080/00016489.2023.2222149","DOIUrl":"10.1080/00016489.2023.2222149","url":null,"abstract":"<p><strong>Background: </strong>Temporal bone paragangliomas are rare tumours with variable presentation that can be hereditary. Identification of clinical and genetic factors of aggressive tumour behaviour is important.</p><p><strong>Objective: </strong>To determine the underlying genetic mutations and genotype/phenotype correlations in a multi-ethnic population of South Florida with sporadic temporal bone paragangliomas.</p><p><strong>Methods: </strong>In a cohort of glomus tympanicum (GT) and glomus jugulare (GJ) cases, we assessed the frequency of pathogenic single nucleotide variants, insertions, deletions, and duplications in coding exons of genes that have been associated with paragangliomas (SDHB, SDHC, SDHD, SDHA, SDHAF2, RET, NF1, VHL, TMEM127, and MAX).</p><p><strong>Results: </strong>None of the 12 GT cases had mutations. Among 13 GJ cases, we identified four mutation carriers (31%); two in SDHC, one in SDHB, and one in SDHD. All patients with pathogenic mutations were of Hispanic ethnicity, presented at a younger age (mean 27.5 versus 52.11 years), and with more advanced disease when compared to mutation-negative GJ cases.<b>Conclusions and Significance:</b> Mutations in the SDH genes are found in 31% of sporadic GJ. SDH-associated GJ had advanced disease and a 50% risk of metastasis. Our data supports emerging recommendations for genetic screening in all populations with GJ tumours as the genetic status informs management.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 7","pages":"551-557"},"PeriodicalIF":1.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10086569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum fat-soluble vitamin levels may be related to sudden sensorineural hearing loss.","authors":"Haifeng Zheng,&nbsp;Miao Liu,&nbsp;Hongli Fu,&nbsp;Lidong Zhao","doi":"10.1080/00016489.2023.2220365","DOIUrl":"10.1080/00016489.2023.2220365","url":null,"abstract":"<p><strong>Background: </strong>Few related studies reported yet the association between vitamins and the onset of sudden sensorineural hearing loss (SSNHL).</p><p><strong>Objective: </strong>To explore the relationship between the serum levels of fat-soluble vitamins A, D, and E and the risk of SSNHL.</p><p><strong>Methods: </strong>This retrospective analysis included 310 SSNHL patients and 154 people without risk of hearing loss. The demographic information of all participants like age, gender, body mass index, occupation, cigarette smoking or drinking status, etc. were recorded. The serum levels of vitamins A, D, and E were determined using the electrochemical method.</p><p><strong>Results: </strong>The results indicated that serum vitamin D levels in SSNHL patients were significantly lower. Vitamin D deficiency was only observed in SSNHL group. Similarly, serum vitamin A levels in female SSNHL patients were significantly lower than the control group. Meanwhile, serum vitamin E levels in male SSNHL patients were significantly lower than the control group.</p><p><strong>Conclusion and significance: </strong>Our results revealed that the serum levels of fat-soluble vitamins A, D, and E in SSNHL patients were lower than those in the control group with normal hearing, indicating that the decrease of serum fat-soluble vitamins may be related to SSNHL pathogenesis.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 7","pages":"576-581"},"PeriodicalIF":1.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10405182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical role of vitamin D, vitamin B12, folate levels and hematological parameters in patients with sudden sensorineural hearing loss.","authors":"Nurdan Kose Celebi,&nbsp;Hande Senem Deveci,&nbsp;Semra Kulekci Ozturk,&nbsp;Tugba Aslan Dundar","doi":"10.1080/00016489.2023.2235398","DOIUrl":"10.1080/00016489.2023.2235398","url":null,"abstract":"<p><strong>Background: </strong>Sudden sensorineural hearing loss (SSNHL), which is frequently observed in otolaryngology clinics, is characterized by sudden onset hearing loss that can develop within hours or days. Its etiology is still not fully understood.</p><p><strong>Aims/objectives: </strong>This research aims to identify prognostic biomarkers that can be utilized to assess the progress of SSNHL as well as circumstances that may predispose individuals to the disease.</p><p><strong>Materials and methods: </strong>Between 1 January 2019 and 1 October 2020, patients diagnosed with SSNHL in our clinic and a control group consisting of healthy people were examined retrospectively. The files of the groups were examined and the levels of hemoglobin, Neutrophil-Lymphocyte Ratio (NLR), ferritin, iron, iron binding capacity (UIBC), vitamin D, vitamin B12, folate were statistically compared with the control group. In addition, the effect of the parameters studied in the patient group on the degree of recovery was examined.</p><p><strong>Results: </strong>There was no statistically significant difference between the groups in terms of mean age and gender distribution (<i>p</i> > .05). NLR level of the patient group was higher than the control group (<i>p</i> < .05). Vitamin D level of the patient group was lower than the control group (<i>p</i> < .05). NLR and vitamin D levels had no effect on the degree of recovery (<i>p</i> > .05). There was no significant difference between the groups in terms of other parameters (<i>p</i> > .05).</p><p><strong>Conclusions and significance: </strong>We think that our study can be a guide for adding vitamin D as a routine laboratory test in patients with SSNHL. In addition, we think that NLR value can be used as a marker in patients with SSNHL. It is recommended to investigate the role of vitamin D supplementation in better and faster response in these patients.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 7","pages":"596-601"},"PeriodicalIF":1.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10087789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of SSNHL with and without tinnitus: audiologic and hematologic differences.","authors":"Jung Min Kim,&nbsp;Hwa Sung Rim,&nbsp;Sung Soo Kim,&nbsp;Sang Hoon Kim,&nbsp;Jae Yong Byun,&nbsp;Seung Geun Yeo","doi":"10.1080/00016489.2023.2229376","DOIUrl":"10.1080/00016489.2023.2229376","url":null,"abstract":"<p><strong>Background and objectives: </strong>Tinnitus is one of the most common symptoms of sudden sensorineural hearing loss (SSNHL), with the incidence of tinnitus in patients with SSNHL ranging from 60% to 90%. Little is known, however, about the specific audiologic and hematologic factors that may be associated with the development of tinnitus. To better understand the relationship between tinnitus and SSNHL, the present study compared audiologic and hematologic factors in SSNHL patients with tinnitus and without tinnitus.</p><p><strong>Subjects and method: </strong>The present study compared 120 patients with SSNHL with tinnitus and 59 patients with SSNHL without tinnitus at their initial examination. Their audiology and hematologic test results were analyzed, and hearing recovery was determined by comparing the hearing thresholds before and after treatment.</p><p><strong>Results: </strong>120 patients with tinnitus showed longer III and V latency in auditory brainstem response (ABR) tests, lower signal-to-noise ratios (SNR) at 2 kHz in transient evoked otoacoustic emissions (TEOAE) tests, and lower response rates at 2 kHz in distortion product otoacoustic emissions (DPOAE) tests of the affected ear (<i>p</i> < 0.05 each) than the 59 patients without tinnitus. However, there were no significant between-group differences in the mean hearing threshold and hearing recovery rate of the affected ear. Patients with tinnitus had significantly worse mean hearing thresholds and hearing thresholds at 4 kHz in the nonaffected ear. The percentages of monocytes and large unstained cells (%LUCs) were higher in the group without tinnitus (<i>p</i> < 0.05), although there were no significant between-group differences in inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR).</p><p><strong>Conclusion: </strong>Tinnitus accompanying SSNHL may be associated with baseline hearing level, as well as being an indicator of damage to outer hair cells and auditory nerves. Additional studies are needed to evaluate hematologic data in SSNHL patients with and without tinnitus.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 7","pages":"589-595"},"PeriodicalIF":1.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10030226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Otosclerosis and stapedotomy: hearing improvement, complications, and analysis of potential prognostic factors in a series of 93 cases.","authors":"Charlotte Wedel,&nbsp;Niels H Holm,&nbsp;Frank Mirz,&nbsp;Therese Ovesen","doi":"10.1080/00016489.2023.2231973","DOIUrl":"10.1080/00016489.2023.2231973","url":null,"abstract":"<p><strong>Background: </strong>Stapedotomy is a common treatment for conductive hearing loss in otosclerosis patients.</p><p><strong>Aims/objectives: </strong>Results of stapedotomy were assessed in terms of hearing improvement and risk of complications. Potential prognostic factors affecting outcomes were identified.</p><p><strong>Material and methods: </strong>Retrospectively, 93 stapedotomies were evaluated. The primary outcome was hearing improvement based on postoperative ABG ≤10 dB, Belfast rule of thumb, and AC gain ≥20 dB. Secondary outcomes were postoperative complications. Additionally, prognostic factors potentially affecting outcomes were analyzed (age, gender, comorbidity, preoperative audiometry, tinnitus, or vertigo).</p><p><strong>Results: </strong>A mean ABG of ≤10 dB was achieved in 59%. According to the Belfast rule of thumb, 75% achieved interaural symmetry within ≤15 dB and/or a mean AC₄ of ≤30 dB. A gain in AC₄ of ≥20 dB was achieved in 57% of primary surgeries. The larger the preoperative ABG, the better hearing after surgery. There was no significant difference in hearing improvement at early and late follow-ups. Transient vertigo was the most common complaint (37%). Taste disturbances were the most frequent permanent complication (14%).</p><p><strong>Conclusion and significance: </strong>Stapedotomy gave good audible improvement with a low risk of complications. Preoperative ABG was the only prognostic factor affecting the hearing outcome. Only one follow-up 6-12 months seems relevant.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 7","pages":"563-569"},"PeriodicalIF":1.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10032957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The timing and methods for detection of recurrence in patients with head and neck cancer.","authors":"Satoru Miyamaru,&nbsp;Kohei Nishimoto,&nbsp;Daizo Murakami,&nbsp;Kaoruko Kuraoka,&nbsp;Haruki Saito,&nbsp;Yorihisa Orita","doi":"10.1080/00016489.2023.2237520","DOIUrl":"10.1080/00016489.2023.2237520","url":null,"abstract":"<p><strong>Background: </strong>Early detection of head and neck cancer recurrence after curative treatment is crucial for effective salvage treatment.</p><p><strong>Objective: </strong>We aimed to examine the timing and method that allowed early detection of recurrence in each primary and recurrence site.</p><p><strong>Materials and methods: </strong>We enrolled 440 patients with head and neck squamous cell carcinoma (HNSCC) in the oral cavity, oropharynx, hypopharynx, or larynx who underwent curative treatment focusing on surgery at our hospital between 2009 and 2018. We examined the timing and diagnostic method (clinical examination, patient symptoms, or imaging examination) for HNSCC recurrence according to the primary and recurrence sites.</p><p><strong>Results: </strong>Recurrence was observed in 133 patients. In all primary sites, regional recurrence occurred significantly earlier than local and distant recurrences. Local recurrence occurred later in the larynx than in other primary sites. Furthermore, the clinical examination had a higher ratio of detection of local recurrence in the larynx than in the other primary site. Regardless of the primary site, more than half of the regional recurrences and most of the distant recurrences were detected by imaging examination.</p><p><strong>Conclusions and significance: </strong>Imaging examination is preferable for achieving early detection of regional and distant recurrences.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 7","pages":"617-622"},"PeriodicalIF":1.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10386648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphomas of the salivary glands: a systematic review.","authors":"Ahmed Ehsan Al-Khafaf,&nbsp;Fahd Al-Shahrestani,&nbsp;Yusuf Baysal,&nbsp;Lise Mette Rahbek Gjerdrum,&nbsp;Steffen Heegaard,&nbsp;Lars Møller Pedersen,&nbsp;Preben Homøe","doi":"10.1080/00016489.2023.2226689","DOIUrl":"10.1080/00016489.2023.2226689","url":null,"abstract":"<p><strong>Background: </strong>Lymphomas constitute 2% of all salivary gland tumors and are the second most common group of malignancies in the head and neck region.</p><p><strong>Objectives: </strong>In this systematic review, the demographics and characteristics of salivary gland lymphomas are presented.</p><p><strong>Methods: </strong>All types of studies that involve data of salivary gland lymphomas between 1990 and 2020 were identified and screened.</p><p><strong>Results: </strong>A total of 169 articles with 1640 patients were identified. The median age of the patients was 59 years with a range between 10 and 87 years. The anatomic locations of salivary gland lymphomas were distributed with 88% in the parotid glands, 9% in the submandibular glands, 1% in the minor salivary glands, and 0.3% in the sublingual glands. The overall survival at 12 months is high and in line with the outcome of indolent lymphomas in general. The predominant indolent subtypes were extranodal marginal zone lymphomas and follicular lymphomas, whereas the more aggressive subtypes were mainly diffuse large B-cell lymphomas, mantle cell lymphomas, and T-cell lymphomas.</p><p><strong>Conclusion: </strong>In conclusion, lymphomas occur in all salivary glands and mainly in elderly female patients. Sjögren's syndrome is frequently associated. Depending on the anatomical location, the lymphoma subtypes vary in aggressiveness, stage, and prognosis.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 7","pages":"610-616"},"PeriodicalIF":1.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}