Acta Oto-Laryngologica最新文献_第6页

HPV16 status might correlate to increasing tumor-infiltrating lymphocytes in hypopharyngeal cancer. HPV16状态可能与下咽癌中肿瘤浸润淋巴细胞的增加有关。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2221288

Mengyou Ji, Lan Lin, Qiang Huang, Chunyan Hu, Ming Zhang

{"title":"HPV16 status might correlate to increasing tumor-infiltrating lymphocytes in hypopharyngeal cancer.","authors":"Mengyou Ji, Lan Lin, Qiang Huang, Chunyan Hu, Ming Zhang","doi":"10.1080/00016489.2023.2221288","DOIUrl":"https://doi.org/10.1080/00016489.2023.2221288","url":null,"abstract":"Background: Human papillomavirus (HPV) plays a major etiological role in the increasing number of patients with head and neck squamous cell carcinoma (HNSCC).Objectives: This study aimed at exploring the relationship between HPV infection and prognosis in patients with hypopharyngeal carcinoma (HPSCC).Methods: We retrospectively analyzed 108 consecutive patients diagnosed with HPSCC from 2015 to 2018. Real-time fluorescent quantitative PCR and P16 immunohistochemistry were used to detect HPV infection in tissues of patients with hypopharyngeal carcinoma. The numbers of CD8, CD4 and Foxp3 cells in tumor parenchyma were obtained by immunohistochemical counting. Finally, the analysis was performed according to the clinicopathological variables and prognosis of the patients.Results: Among 108 patients with HPSCC, 18 cases were detected by qPCR, and 16 subtypes accounted for the majority (77.8%). Kaplan-Meier analysis showed that HPV16+, higher CD8+, higher CD4+ and higher FoxP3+ TIL infiltration was strongly associated with superior three-year disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS). Univariate analysis showed that HPV and CD4+ TIL had higher predictive value for prognosis.Conclusions: HPV16 infection is significantly related to tumor immune infiltrating cells (TILs).","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 6","pages":"543-550"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10174927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Preoperative factors influencing the rate and speed of available communication ability in prelingual paediatric cochlear implantation recipients. 影响语前儿童人工耳蜗植入受者有效沟通能力的术前因素。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2220755

Hui-Ru Fan, Dan Li, Shan-Hong Wang, Wei-Jia Kong

{"title":"Preoperative factors influencing the rate and speed of available communication ability in prelingual paediatric cochlear implantation recipients.","authors":"Hui-Ru Fan, Dan Li, Shan-Hong Wang, Wei-Jia Kong","doi":"10.1080/00016489.2023.2220755","DOIUrl":"https://doi.org/10.1080/00016489.2023.2220755","url":null,"abstract":"Background: Few studies have assessed factors influencing the rate and speed of good outcomes in cochlear implantation (CI) children.Objective: To analyse the factors influencing the rate and speed of available communication in CI children.Material and methods: The study involved 316 children. The categories of auditory performance (CAP) and speech intelligibility rating (SIR) were used to evaluate outcomes. Multivariable proportional Cox regression models were established to analyse the effect of preoperative factors.Results: Five variables were entered into the three multivariable models of CAP ≥6, SIR ≥4 and concurrent CAP ≥6 and SIR ≥4. Older age at implantation was a significant poor factor in the three models with estimated hazard ratios (HRs) of .541, .629, and .554, respectively. Another negative factor was poor parental literacy for the three outcomes (HR .639, .638, and .542, respectively). More than 3 months of rehabilitation from institutes had a positive effect on CAP ≥6 and concurrent CAP ≥6 and SIR ≥4 (HR 1.626 and 1.667, respectively).Conclusions and significance: Older age at implantation and poor parental literacy were negative factors. Receiving regular rehabilitation from institutes pre-CI could help the children gain available communication ability earlier on.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 6","pages":"481-488"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9788713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-exome sequencing for screening noise-induced hearing loss susceptibility genes. 全外显子组测序筛选噪声性听力损失易感基因。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2201287

Boya Fan, Gang Wang, Gang Liu, Xiaoli Zhang, Wei Wu

{"title":"Whole-exome sequencing for screening noise-induced hearing loss susceptibility genes.","authors":"Boya Fan, Gang Wang, Gang Liu, Xiaoli Zhang, Wei Wu","doi":"10.1080/00016489.2023.2201287","DOIUrl":"https://doi.org/10.1080/00016489.2023.2201287","url":null,"abstract":"Background: High-throughput sequencing of genes indicating susceptibility to noise-induced hearing loss has not previously been reported.Aims/objectives: To identify and analyze genes associated with susceptibility to noise-induced hearing loss (NIHL) and characterize differences in susceptibility to hearing loss by genotype.Material and methods: Pure tone audiometry tests were performed on 113 workers exposed to high-intensity noise. Whole-exome sequencing (WES) was conducted and NIHL susceptibility genes screened for training unsupervised and supervised machine learning models. Immunofluorescence staining of mouse cochlea was used to observe patterns of NIHL susceptibility gene expression.Results: Participants were divided into a NIHL and a control group, according to the results of audiometry tests. Seventy-three possible NIHL susceptibility genes were input into the machine learning model. Two subgroups of NIHL could be distinguished by unsupervised machine learning and the classification was evaluated by the supervised machine learning algorithm. The VWF gene had the highest mutation frequency in the NIHL group and was expressed mainly in the spiral ligament.Conclusions and significance: NIHL susceptibility genes were screened and NIHL subgroups could be distinguished. VWF may be a novel NIHL susceptibility gene.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"408-415"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9884239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncological and functional outcomes of partial or total laryngopharyngectomy for hypopharyngeal cancer with thyroid or cricoid cartilage invasion. 部分或全部喉咽切除术治疗甲状腺或环状软骨侵犯的下咽癌的肿瘤和功能结果。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2205443

Kwang-Jae Cho, Min-Sik Kim, Jung-Hae Cho, Jun-Ook Park, In-Chul Nam, Chung-Soo Kim, Young-Hoon Joo

{"title":"Oncological and functional outcomes of partial or total laryngopharyngectomy for hypopharyngeal cancer with thyroid or cricoid cartilage invasion.","authors":"Kwang-Jae Cho, Min-Sik Kim, Jung-Hae Cho, Jun-Ook Park, In-Chul Nam, Chung-Soo Kim, Young-Hoon Joo","doi":"10.1080/00016489.2023.2205443","DOIUrl":"https://doi.org/10.1080/00016489.2023.2205443","url":null,"abstract":"Background: Patients with cartilage invasion in hypopharyngeal squamous cell carcinoma (HPSCC) would benefit from partial laryngopharyngectomy (PLP).Aims/objectives: The purpose of this study was to examine the treatment outcomes of PLP for HPSCC with cartilage invasion, with a focus on the oncological safety and the function preservation.Materials and methods: We performed a retrospective review of 28 patients with HPSCC with thyroid or cricoid cartilage invasion who had undergone upfront surgery and were followed for more than one year between 1993 and 2019.Results: Twelve patients treated with PLP (42.9%) and 16 patients treated with total laryngopharyngectomy (TLP) for cartilage invasion in HPSCC were identified. There was no significant difference in recurrence between the PLP group (7/12, 58.3%) and the TLP group (8/16, 50.0%) (p = .718). PLP was not associated with decreased five-year disease free survival (p = .662) or disease specific survival (p = .883) rates compared to TLP. Nine patients receiving PLP could be decannulated and retained intelligible speech (9/12, 75%). Gastrostomy tubes were placed in the PLP group (5/12, 42.9%) and TLP group (1/16, 6.2%) (p = .057).Conclusions and significance: PLP appears to be a feasible option for the treatment of thyroid or cricoid cartilage invasion in HPSCC.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"429-433"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9529215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dynamic posturography after computerized vestibular retraining for stable unilateral vestibular deficits. 计算机前庭再训练后动态体位照相治疗稳定的单侧前庭功能缺损。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2208615

Eytan A David, Navid Shahnaz

{"title":"Dynamic posturography after computerized vestibular retraining for stable unilateral vestibular deficits.","authors":"Eytan A David, Navid Shahnaz","doi":"10.1080/00016489.2023.2208615","DOIUrl":"https://doi.org/10.1080/00016489.2023.2208615","url":null,"abstract":"Background: Balance deficits increase the risk of falls and compromise quality of life. Current treatment modalities do not resolve symptoms for many patients.Aims/objectives: To measure changes in objective posturography after a computerized vestibular retraining therapy protocol.Materials and methods: This was a single-arm interventional study of individuals with a stable unilateral vestibular deficit present for greater than six months. Participants underwent 12 twice-weekly sessions of computerized vestibular retraining therapy. Objective response was measured by the Sensory Organization Test and questionnaires were administered to measure subjective changes.Results: We enrolled 13 participants (5 females and 8 males) with a median age of 51 years (range 18 to 67). After retraining, the Sensory Organization Test composite score improved by 8.8 (95% CI 0.6 to 19.1) and this correlated with improvement in the Falls Efficacy Scale-International questionnaire (rs -0.6472; 95% CI -0.8872 to - 0.1316). Participants with moderate-to-severe disability at baseline (n = 7) demonstrated greater improvement in the composite score (14.6; 95% CI 7.0 to 36.9).Conclusions and significance: Computerized vestibular retraining therapy for stable unilateral vestibular deficits is associated with improvement in dynamic balance performance. Posturography improvements correlated with a reduction in perceived fall risk. Trial Registration Information Clinicaltrials.gov registration NCT04875013; 04/27/2021.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"396-401"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9604801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Neuromuscular retraining therapy combined with preceding botulinum toxin A injection for chronic facial paralysis. 神经肌肉再训练联合A型肉毒杆菌毒素注射治疗慢性面瘫。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2207599

Junhui Jeong, Jeon Mi Lee, Jin Kim

{"title":"Neuromuscular retraining therapy combined with preceding botulinum toxin A injection for chronic facial paralysis.","authors":"Junhui Jeong, Jeon Mi Lee, Jin Kim","doi":"10.1080/00016489.2023.2207599","DOIUrl":"https://doi.org/10.1080/00016489.2023.2207599","url":null,"abstract":"Background: Neuromuscular retraining therapy (NMRT) is the central treatment for synkinesis. The efficacy of botulinum toxin type A (BTX-A) may be enhanced with the addition of physical therapy.Objectives: To investigate the effects of NMRT combined with preceding BTX-A injection (NMRT-B) on facial synkinesis and asymmetry in chronic facial paralysis.Materials and methods: We recruited 99 patients with unilateral facial paralysis and no recovery for > 6 months who underwent NMRT-B for > 1 year. The patients were scheduled to receive NMRT after 1-2 weeks of BTX-A injection. We used a computer-based numerical scoring system to evaluate the facial functions. Primary, secondary, and final facial movement scores were evaluated before and after 1 year of treatment.Results: Patients with chronic facial paralysis who underwent NMRT-B exhibited improved facial movement after 1 year of treatment. NMRT-B provided satisfactory control of synkinesis and improved the primary movements. The mean primary and final facial movement scores were significantly increased after treatment, while the mean secondary facial movement scores were significantly decreased.Conclusions and significance: NMRT-B improved the final facial movement in patients with chronic facial paralysis and synkinesis, regardless of the degrees of facial synkinesis and asymmetry before treatment.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"446-451"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9901354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Vestibular test results in patients with vestibular migraine and Meniere's Disease. 前庭偏头痛和梅尼埃病患者的前庭检查结果。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2213723

Fidan Balayeva, Gülce Kirazlı, Nese Celebisoy

{"title":"Vestibular test results in patients with vestibular migraine and Meniere's Disease.","authors":"Fidan Balayeva, Gülce Kirazlı, Nese Celebisoy","doi":"10.1080/00016489.2023.2213723","DOIUrl":"https://doi.org/10.1080/00016489.2023.2213723","url":null,"abstract":"Background: Vestibular migraine (VM) and Meniere's Disease (MD) are episodic vestibular disorders, sometimes difficult to differentiate from each other on clinical grounds.Objective: To evaluate vestibular test results of the two groups that may help in the differential diagnosis.Methods: Twenty-two patients with VM, 21 patients with definite MD and 21 healthy volunteers (HC) were studied. Pure tone hearing thresholds (PTHT), cervical vestibular evoked myogenic potentials (cVEMPs), video head impulse test (vHIT) and functional head impulse test (fHIT) were performed.Results: PTHT of the MD-affected ears were significantly higher than VM and HC groups (p < .001 for both) when cVEMP amplitudes were lower (p = .005 for HC), (p = .006 for VM). Lateral canal vHIT gain of the MD-affected ears were lower than VM patients (p = .003) and the HC (p < .001). The percentage of correctly identified optotypes (CA%) on fHIT was low for both patient groups when compared with the HC (p < .001).Conclusion: In addition to hearing loss, low cVEMP amplitudes on the affected side with decreased gain on vHIT indicate disturbed saccular and lateral semicircular canal functions in MD patients differentiating them from VM. A functional deficit in gaze stabilization detected by fHIT is the only abnormality found in patients with VM.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 6","pages":"471-475"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10171509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refining feasibility assessment of endoscopic ear surgery: a radiomics model utilizing machine learning on external auditory canal CT scans. 改进内窥镜耳部手术的可行性评估:利用外耳道CT扫描机器学习的放射组学模型。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2208180

Shuainan Chen, Fang Lucheng, Licai Shi, Anying Zou, Xingwang Rao, Rujie Li, Jiahui Zheng, Wei Guo, Yideng Huang

{"title":"Refining feasibility assessment of endoscopic ear surgery: a radiomics model utilizing machine learning on external auditory canal CT scans.","authors":"Shuainan Chen, Fang Lucheng, Licai Shi, Anying Zou, Xingwang Rao, Rujie Li, Jiahui Zheng, Wei Guo, Yideng Huang","doi":"10.1080/00016489.2023.2208180","DOIUrl":"https://doi.org/10.1080/00016489.2023.2208180","url":null,"abstract":"Background: Feasibility assessment of endoscopic ear surgery (EES) relies solely on subjective evaluation by surgeons.Objective: Extracting radiomic features from preoperative CT images of the external auditory canal, we aim to classify EES patients into easy and difficult groups and improve accuracy in determining surgery feasibility.Methods: 85 patients' external auditory canal CT scans were collected and 139 radiomic features were extracted using PyRadiomics. The most relevant features were selected and three machine learning algorithms (logistic regression, support vector machine, and random forest) were compared using K-fold cross-validation (k = 5) to predict surgical feasibility.Results: The best-performing machine learning model, the support vector machine (SVM), was selected to predict the difficulty of EES. The proposed model achieved a high accuracy of 86.5%, and F1 score of 84.6%. The area under the ROC curve was 0.93, indicating good discriminatory power.Conclusions and significance: The proposed machine learning model provides a reliable and accurate method for classifying patients undergoing otologic surgery based on preoperative imaging data. The model can help clinicians to better prepare for challenging surgical cases and optimize treatment plans for individual patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"382-386"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of cochlear implant and bimodal stimulation on tinnitus: a multinational survey. 耳蜗植入和双峰刺激对耳鸣的影响:一项跨国调查。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2210618

Nicola Quaranta, David Baguley, Piero Fanizzi, Alessandra Murri, Vito Pontillo, Jodie Michelle Cutler, Giada Cavallaro

{"title":"The effect of cochlear implant and bimodal stimulation on tinnitus: a multinational survey.","authors":"Nicola Quaranta, David Baguley, Piero Fanizzi, Alessandra Murri, Vito Pontillo, Jodie Michelle Cutler, Giada Cavallaro","doi":"10.1080/00016489.2023.2210618","DOIUrl":"https://doi.org/10.1080/00016489.2023.2210618","url":null,"abstract":"Background: Tinnitus is a frequent symptom in cochlear implant (CI) patients. Many studies have shown that a CI leads to a significant change in the perception of tinnitus.Aims: The aim of the present study was to evaluate the effect of CI on tinnitus in patients with Unilateral Cochlear Implant (UCI), Bilateral Cochlear Implant (BCI), and Bimodal Stimulation (BMS).Material and methods: A survey was administered online to CI patients. The Tinnitus Handicap Inventory (THI) score was calculated. Emotional, functional, and catastrophic subscales scores were calculated. The intensity and annoyance of tinnitus were graded using a scale from 1 to 10.Results: 130 participants represented the study group; the Average THI score was 38.3 (SD: 26.3) in UCI, 32.4 (SD 25.8) in BCI users, and 42.5 (SD 28.2) in BMS: no significant difference was found among the three groups. CI users for less than 1 year showed significantly higher THI scores compared to CI users for more than 5 years (p = .0275). The intensity and annoyance of tinnitus significantly decreased with the CI on compared to the CI off condition.Conclusions and significance: Taken together, our findings support CI's efficacy in reducing the perception of tinnitus. No significant differences were evident between unilateral and bilateral electrical stimulation in terms of tinnitus improvement.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 6","pages":"476-480"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9852276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholesteatoma in chronic otitis media secondary to pars tensa perforation. 慢性中耳炎继发于紧张部穿孔的胆脂瘤。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2200437

Caili Ji, Xiaowen Zhang, Xudong Yan, Songli Cao, Tao Fu

{"title":"Cholesteatoma in chronic otitis media secondary to pars tensa perforation.","authors":"Caili Ji, Xiaowen Zhang, Xudong Yan, Songli Cao, Tao Fu","doi":"10.1080/00016489.2023.2200437","DOIUrl":"https://doi.org/10.1080/00016489.2023.2200437","url":null,"abstract":"Background: Acquired cholesteatoma secondary to pars tensa perforation was rare in clinic.Objectives: In this study, we explored factors related to acquired cholesteatoma in chronic otitis media patients with pars tensa perforation.Material and methods: 262 adults (296 ears) with pars tensa perforation were divided into four groups: anterior perforation group, posterior perforation group, central perforation group, and marginal perforation group. Analysis was carried out in terms of cholesteatoma formation, adhesion of perforation edges, mastoid pneumatization, and the function of eustachian tube.Results: Cholesteatoma was found in 34% (18 in 53 ears) in posterior perforation group, 14.3% (14 in 98 ears) in marginal perforation group, and 2.5% (2 in 80 ears) in anterior perforation group. For subjects with adhesion in perforation edges, cholesteatoma was approved in 94% of posterior perforation, 42% of marginal perforation and 25% of anterior perforation groups. The adhesion in perforation edges and function of eustachian tube instead of mastoid pneumatization were statistically significant for cholesteatoma formation.Conclusions and significance: Acquired cholesteatoma was mostly found in patients with posterior and marginal perforation, followed by anterior perforation. Adhesion of perforation edges was another risk factor for cholesteatoma formation. Eustachian tube also functioned by influencing the ventilation of middle ear.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"376-381"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9582309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0