Acta Oto-Laryngologica最新文献_第7页

Auditory and cognitive abilities in patients with chronic kidney disease: a comparative study across stages. 慢性肾脏疾病患者的听觉和认知能力：一项跨阶段的比较研究

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-22 DOI: 10.1080/00016489.2025.2489665

Tuana Saglanmak, Aysenur Kucuk Ceyhan

{"title":"Auditory and cognitive abilities in patients with chronic kidney disease: a comparative study across stages.","authors":"Tuana Saglanmak, Aysenur Kucuk Ceyhan","doi":"10.1080/00016489.2025.2489665","DOIUrl":"https://doi.org/10.1080/00016489.2025.2489665","url":null,"abstract":"Background: The impact of chronic kidney disease (CKD) on peripheral hearing is well documented, but little is known about the impact on auditory processing.Aim: This study aimed to evaluate auditory processing and cognitive abilities in CKD and to assess changes according to the disease phases.Materials and methods: Eighty-nine CKD patients, aged 25-65 (48 study and 41 control) with stages 2-4, participated. Random Gap Detection Test (RGDT), Frequency Pattern Test (FPT), Duration Pattern Test (DPT), the Digit Span Backward Task (DSBT) and the speech discrimination (SD) in noise and in quiet test were employed.Results: The comparison between the two groups indicated significant decreases in test scores for the RGDT, FPT, DPT, DSBT, and SD (in noise) within in the group with CKD (p < .001). The SD (in quiet) test exhibits no difference. There were no significant variations in any evaluated parameter between CKD stages.Conclusions and significance: The results indicate that CKD can impair auditory and cognitive processing, hence affecting SD, especially in challenging auditory environments. Nevertheless, no significant changes were observed across the phases of CKD, suggesting that impairments in these capacities may appear early in the course of the disease.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic hearing thresholds after glycerol ingestion may be modified by endolymphatic hydrops status in Ménière's disease. 摄入甘油后的动态听力阈值可能会因内淋巴积液状态而改变。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-16 DOI: 10.1080/00016489.2025.2489646

Hui Pan, Ping Lei, Qin Liu, Yingzhao Liu, Kaijun Xia, Xingqian Shen, Xiaoye Chen, Ziying Xu, Wenliang Fan, Yangming Leng, Bo Liu

{"title":"Dynamic hearing thresholds after glycerol ingestion may be modified by endolymphatic hydrops status in Ménière's disease.","authors":"Hui Pan, Ping Lei, Qin Liu, Yingzhao Liu, Kaijun Xia, Xingqian Shen, Xiaoye Chen, Ziying Xu, Wenliang Fan, Yangming Leng, Bo Liu","doi":"10.1080/00016489.2025.2489646","DOIUrl":"https://doi.org/10.1080/00016489.2025.2489646","url":null,"abstract":"Background: Endolymphatic hydrops (ELH) can be identified by electrophysiological and radiological examinations.Objectives: We aimed to investigate the relationship between audiometric glycerol test and delayed magnetic resonance imaging (MRI) of the inner ear after intratympanic gadolinium in patients with unilateral Ménière's disease (MD).Material and methods: Forty-two patients with unilateral definite MD underwent audiometric glycerol test and delayed MRI following intratympanic gadolinium application.Results: The degree of cochlear ELH was moderately positively correlated with the mean hearing threshold below 2 kHz. For those ears with positive glycerol results, the best hearing threshold was measured at 3 h and the maximal improvement of hearing threshold was observed within the third hour. The overall positive rates of glycerol test did not differ between ELH (+) and ELH (-) subgroups based on the MRI findings. Significant temporal changes in the positive rate were only observed in the ELH (+) subgroup. The rebound rate did not change significantly over time in either subgroup.Conclusions and significance: In MD patients, glycerol-induced dynamic shift of hearing threshold may be modified by the hydropic status of the inner ear. For those without radiological ELH, glycerol test could be used as additional diagnostic tool to detect hydrops.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the role of vestibular function in motion sickness and visually induced motion sickness by multiple vestibular function tests. 通过多次前庭功能试验探讨前庭功能在晕动病和视动病中的作用。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-16 DOI: 10.1080/00016489.2025.2486609

Jing Zhao, Linyao Shi, Xiaoming Li, Chuanxia Cao, Qikun Zhang, Chuanjing Qiu, Jiamei Lu, Shuai Pan, Jing Xue, Zhanguo Jin, Shengguang Yan

{"title":"Investigating the role of vestibular function in motion sickness and visually induced motion sickness by multiple vestibular function tests.","authors":"Jing Zhao, Linyao Shi, Xiaoming Li, Chuanxia Cao, Qikun Zhang, Chuanjing Qiu, Jiamei Lu, Shuai Pan, Jing Xue, Zhanguo Jin, Shengguang Yan","doi":"10.1080/00016489.2025.2486609","DOIUrl":"https://doi.org/10.1080/00016489.2025.2486609","url":null,"abstract":"Background: Motion sickness (MS) and visually induced motion sickness (VIMS) are vestibular system-related conditions affecting balance.Objectives: To investigate the role of vestibular function and susceptibility in MS/VIMS in healthy college students and to evaluate the effectiveness of various vestibular function tests in detecting these disorders.Materials and methods: Five hundred young adults, grouped by motion sickness susceptibility questionnaire-short (MSSQ-S) and visually induced motion sickness susceptibility questionnaire-short (VIMSSQ-S) questionnaires, were further analyzed via continuous linear regression to validate the grouping strategy. The participants completed a caloric test (CT), video head impulse test (vHIT), dynamic visual acuity (DVA), subjective visual vertical/horizontal (SVV/SVH), and sensory organisation tests (SOT). Analysis of the relationship between the results of the five tests and the MS/VIMS.Results: CT revealed significant differences in right cold slow-phase velocity (RC SPV) and left cold slow-phase velocity (LC SPV) among groups (p < 0.001), with strong correlations between these values and MS/VIMS susceptibility (p < 0.05). Among 52 subjects with abnormal CT results, significant differences were found in vHIT, DVA, and SOT (p < 0.001), while SVV/SVH showed a significant difference only in MSSQ-S scores (p = 0.034).Conclusions and significance: This study comprehensively assessed vestibular function in MS and VIMS susceptible individuals, confirming increased sensitivity and highlighting the need for targeted evaluation strategies.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-10"},"PeriodicalIF":1.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of factors affecting the efficacy of bilateral posterior semicircular canal occlusion in the treatment of refractory benign paroxysmal positional vertigo. 影响双侧后半规管闭塞治疗难治性良性阵发性位置性眩晕疗效的因素分析。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-16 DOI: 10.1080/00016489.2025.2490296

Hui Yong, Lingling Di, Zhikai Wang, Jing Kang, Pei Yang, Xiaoping Gao

{"title":"Analysis of factors affecting the efficacy of bilateral posterior semicircular canal occlusion in the treatment of refractory benign paroxysmal positional vertigo.","authors":"Hui Yong, Lingling Di, Zhikai Wang, Jing Kang, Pei Yang, Xiaoping Gao","doi":"10.1080/00016489.2025.2490296","DOIUrl":"https://doi.org/10.1080/00016489.2025.2490296","url":null,"abstract":"Background: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular disorder. Refractory cases persist despite ≥3 repositioning maneuvers over 6 months.Objective: To identify factors influencing bilateral posterior semicircular canal occlusion (BPCO) efficacy in refractory BPPV.Methods: A retrospective study included 120 refractory BPPV patients undergoing BPCO. Patients were divided into Group A (successful outcomes, n = 84) and Group B (suboptimal outcomes, n = 36) based on postoperative DHI reduction (≥50% vs. <50%).Results: Group B had a higher mean age (69.85 ± 4.15 vs. 62.28 ± 3.64 years, p =.012), longer disease duration (≥1 year: 30.56% vs. 10.73%, p < .01), and more bilateral BPPV (16.67% vs. 5.96%, p < .01). At 6 months, Group B showed poorer outcomes: higher dizziness handicap inventory (DHI) scores (53.24 ± 5.39 vs. 30.11 ± 2.88), lower SF-36 scores (58.10 ± 5.32 vs. 81.45 ± 6.29), higher recurrence rates (38.89% vs. 7.14%), and more frequent attacks (13.75 ± 3.66 vs. 4.36 ± 1.25/month) (p < .05). Multivariate analysis confirmed age, disease duration, and bilateral BPPV as independent risk factors (p < .01).Conclusions: Older age (≥65 years), prolonged disease duration (≥1 year), and bilateral BPPV predict poor BPCO outcomes in refractory BPPV. These factors are critical for preoperative decision-making.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic, survival, and tumor control outcomes of parapharyngeal space liposarcoma: a systematic review. 咽旁间隙脂肪肉瘤的诊断、生存和肿瘤控制结果：一项系统综述。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1080/00016489.2025.2462688

Srivatsa Surya Vasudevan, Estephania Candelo, Tiba Yamin Kandrikar, Jeffrey R Janus

{"title":"Diagnostic, survival, and tumor control outcomes of parapharyngeal space liposarcoma: a systematic review.","authors":"Srivatsa Surya Vasudevan, Estephania Candelo, Tiba Yamin Kandrikar, Jeffrey R Janus","doi":"10.1080/00016489.2025.2462688","DOIUrl":"10.1080/00016489.2025.2462688","url":null,"abstract":"Background: Parapharyngeal space liposarcomas (PPS-LS) are rare tumors often associated with a moderate-to-poor prognosis.Objectives: This study aims to assess tumor control and survival outcomes across the various subtypes of PPS-LS.Material and methods: We conducted a systematic review of cases using PubMed, OVID, Scopus, Web of Science, ScienceDirect, and EBSCO from inception to October 2024. Given the data on individual patient follow-up, Kaplan-Meier survival analysis was utilized to calculate disease-free survival (DFS) and disease-specific survival (DSS).Results: Out of 303 articles, 10 studies with 11 patients (72.7% male) met the inclusion criteria, with a mean age of 51.3 years (range: 12-77.5). Preoperative fine needle aspiration cytology was conducted in 45.4%, with 80% yielding inconclusive results. The 2-year and 5-year DFS rates for PPS-LS were 64% and 50%, respectively, while the 2-year DSS rate was 84%. Tumor recurrence occurred in 36.3% of patients, with an average of 2.5 recurrences per patient, specifically the myxoid subtype of PPS-LS.Conclusion: This systematic review highlights the varied prognostic outcomes of PPS-LS and its subtypes, emphasizing the need for vigilant surveillance to improve DFS and reduce recurrence rates.Significance: This provides surgeons with critical insights into probable prognostic outcomes when dealing with specific subtypes of PPS-LS.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"348-354"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of nasal microplastic densities in patients with acute and chronic rhinitis. 急慢性鼻炎患者鼻腔微塑性密度的评价。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1080/00016489.2025.2468396

Ayşegül Tuna, Yeşim İtmeç, Birgül Kaçmaz, Serdar Gül, Sedat Kaygusuz

{"title":"Evaluation of nasal microplastic densities in patients with acute and chronic rhinitis.","authors":"Ayşegül Tuna, Yeşim İtmeç, Birgül Kaçmaz, Serdar Gül, Sedat Kaygusuz","doi":"10.1080/00016489.2025.2468396","DOIUrl":"10.1080/00016489.2025.2468396","url":null,"abstract":"Background: Increasing plastic consumption has made microplastics a persistent environmental pollutant present in the atmosphere and other ecosystems. These particles can enter biological tissues via ingestion, skin contact, or inhalation and potentially cause rhinitis and other respiratory diseases through inflammatory and cytotoxic effects.Objectives: This study evaluated the association between nasal inhalation of microplastics, a contributor to air pollution, and rhinitis symptoms, as well as their role in the etiology of acute and chronic rhinitis.Materials and methods: Sixty patients were equally divided into two groups: acute rhinitis (30 patients) and chronic rhinitis (30 patients). Demographic data, including age and gender, and total nasal symptom scores were recorded. Nasal lavage samples were collected and the number of microplastics in these samples was analyzed. Groups were compared based on microplastic counts.Results: The acute rhinitis group had significantly higher microplastic levels than the chronic rhinitis group. Microplastics were detected in at least one sample from each participant, regardless of gender, age, or symptom score.Conclusions and significance: The higher concentration of microplastics in acute rhinitis highlights their potential role in exacerbations and underscores the need for preventive strategies and further research on their long-term health effects.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"308-312"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gap-induced inhibition of the post-auricular muscle response in miniature pigs. 缝隙诱导的对小型猪耳后肌肉反应的抑制。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1080/00016489.2025.2464698

Hanwen Zhou, Peng Liu, Chi Zhang, Xinmiao Xue, Xuemin Chen, Zhixin Zhang, Weidong Shen, Shiming Yang, Mengyun Fan, Fangyuan Wang

{"title":"Gap-induced inhibition of the post-auricular muscle response in miniature pigs.","authors":"Hanwen Zhou, Peng Liu, Chi Zhang, Xinmiao Xue, Xuemin Chen, Zhixin Zhang, Weidong Shen, Shiming Yang, Mengyun Fan, Fangyuan Wang","doi":"10.1080/00016489.2025.2464698","DOIUrl":"10.1080/00016489.2025.2464698","url":null,"abstract":"Background: Tinnitus, a persistent condition that significantly impairs the quality of life for patients, poses a substantial burden on society. Owing to its complex and poorly understood pathogenesis, the development of effective animal models for tinnitus is imperative to enhance our comprehension of this condition.Objectives: The present study aims to establish a large animal model to delineate the mechanisms underlying the onset of tinnitus.Materials and methods: For the first time, we conducted a comparative analysis of the Post-Auricular Muscle Response (PAMR) and the Eye Blink Response (EBR) in miniature pigs, demonstrating their utility in manifesting Gap Prepulse Inhibition of the Acoustic Startle (GPIAS). Subsequently, we employed the gap-induced inhibition of PAMR to ascertain evidence of tinnitus following noise exposure.Results and conclusion: Through comparing the efficacy of PAMR and EBR in GPIAS detection, we have substantiated that PAMR provides a stable and objective reflection of GPIAS. Consequently, PAMR emerges as a reliable method for measuring GPIAS in miniature pigs. Furthermore, the behavioral paradigm of gap-induced inhibition of PAMR successfully identified behavioral evidence of tinnitus subsequent to noise exposure.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"291-298"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative and qualitative evaluation of anti-pneumococcal specific antibodies in children with recurrent acute otitis media. 复发性急性中耳炎患儿抗肺炎球菌特异性抗体的定量和定性评价。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.1080/00016489.2025.2468397

Masamitsu Kono, Eisuke Kuroda, Takuro Iyo, Nafisa Khamis Umar, Ayumi Hirayama, Saori Takeda, Daichi Murakami, Shigeto Hamaguchi, Muneki Hotomi

{"title":"Quantitative and qualitative evaluation of anti-pneumococcal specific antibodies in children with recurrent acute otitis media.","authors":"Masamitsu Kono, Eisuke Kuroda, Takuro Iyo, Nafisa Khamis Umar, Ayumi Hirayama, Saori Takeda, Daichi Murakami, Shigeto Hamaguchi, Muneki Hotomi","doi":"10.1080/00016489.2025.2468397","DOIUrl":"10.1080/00016489.2025.2468397","url":null,"abstract":"Background: Pneumococcal conjugated vaccine (PCV) has contributed to a dramatic reduction in invasive pneumococcal diseases. However, its impact upon nasopharyngeal carriage and upper respiratory tract infections is unclear.Aims/objectives: This study was aimed to evaluate the humoral immunity against Streptococcus pneumoniae in children with recurrent acute otitis media (rAOM) in the post PCV era.Materials and methods: We evaluated the humoral immunity against eight representative serotypes included in PCV13 (3, 6 A, 6B, 9 V, 14, 18 C, 19 F, and 23 F) among children with rAOM.Results: Serum total immunoglobulin levels were typically within the normal range, but there was a decrease in IgG2 in >20% of cases. Serotype-specific antibody titers were not significantly different for any serotype in the rAOM group compared with the healthy controls, except for serotype 3. Conversely, the ability of serotype-specific antibodies to induce opsonophagocytic killing was increased in the rAOM group for three serotypes (6 A, 6B, and 14). There was a positive correlation between the titer of antibodies and the opsonophagocytic killing activity in five serotypes (6 A, 6B, 9 V, 19 F, and 23 F).Conclusion and significance: Quantitative and qualitative evaluation of serotype-specific antibodies would be an important method for evaluating humoral immunity in children with rAOM.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"283-290"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifaceted evaluation of the effects of smoking on Eustachian tube function. 吸烟对咽鼓管功能影响的多方面评价。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-22 DOI: 10.1080/00016489.2025.2468911

Aykut Yankuncu, İrem Bozkurt Karaçuha, Sema Zer Toros, Çiğdem Tepe Karaca

{"title":"Multifaceted evaluation of the effects of smoking on Eustachian tube function.","authors":"Aykut Yankuncu, İrem Bozkurt Karaçuha, Sema Zer Toros, Çiğdem Tepe Karaca","doi":"10.1080/00016489.2025.2468911","DOIUrl":"10.1080/00016489.2025.2468911","url":null,"abstract":"Background: The Eustachian tube is essential for middle ear health, ensuring pressure equalization, ventilation, and protection from pathogens. Smoking has been linked to altered Eustachian tube function, affecting mucociliary activity and middle ear ventilation.Aims/objectives: This study evaluates smoking's impact on Eustachian tube function using tympanometry, nasal mucociliary clearance testing, and the Eustachian Tube Dysfunction Questionnaire.Material and methods: Healthy adults aged 20-50 years with intact tympanic membranes, no upper respiratory infections, or nasal pathologies were included. Participants were divided into smokers (subgrouped by smoking history: 5-10, 10-20, and >20 pack-years) and non-smokers. Tympanometry, mucociliary clearance testing, and the questionnaire were administered.Results: Among 276 participants, significant differences in questionnaire scores, compliance, middle ear pressure, and mucociliary clearance times were observed between groups (p < 0.01, p = 0.02, p < 0.001, and p = 0.009, respectively). Ipsilateral acoustic reflexes differed significantly between groups (p < 0.005 and p = 0.049). Mucociliary clearance times were notably prolonged in the >20 pack-years group compared to the 5-10 pack-years group (p = 0.012).Conclusions and significance: Smoking adversely affects Eustachian tube function, as evidenced by tympanometric, mucociliary, and questionnaire assessments.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"303-307"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The auxiliary effect of vitamin D in the treatment of chronic rhinosinusitis with nasal polyposis, a clinical trial. 维生素D辅助治疗慢性鼻窦炎伴鼻息肉病的临床试验。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-14 DOI: 10.1080/00016489.2025.2459344

Mehdi Bakhshaee, Seyed Saeed Hosseini, Abolfazl Zanghaei, Mona Najaf Najafi, Fatemeh Bavi, Imaneh Roshanzamir

{"title":"The auxiliary effect of vitamin D in the treatment of chronic rhinosinusitis with nasal polyposis, a clinical trial.","authors":"Mehdi Bakhshaee, Seyed Saeed Hosseini, Abolfazl Zanghaei, Mona Najaf Najafi, Fatemeh Bavi, Imaneh Roshanzamir","doi":"10.1080/00016489.2025.2459344","DOIUrl":"10.1080/00016489.2025.2459344","url":null,"abstract":"Background: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) is a prevalent chronic inflammatory disorder of the nasal cavity and paranasal sinus with benign polypoid masses. Recent evidence highlights the immunomodulatory role of Vitamin D (Vit D) in mitigating inflammation associated with CRSwNP.Aims: The aim of this study is to examine the effect of Vit D on the improvement of CRSwNP.Material and methods: This randomized, double-blind clinical trial was conducted on 59 patients with CRSwNP. All patients with Vit D deficiency (25OH Vit D level < 20 ng/mL) or insufficiency (<30 ng/mL) underwent endoscopic sinus surgery (ESS). The rate of changes in the patients' symptoms were recorded before and 8 weeks after the surgery.Result: All patients showed a better postsurgical improvement in terms of Visual Analogue Scale(VAS), Lund-Kennedy (LK), and Questionnaire (SNOT-22) scores. The Vit D supplement group showed better postsurgical improvement in comparison to placebo in terms of VAS and LK scores (p = 0.02, p = 0.03 respectively).Conclusions and significance: The administration of Vit D after ESS is relatively effective in the improvement of CRSwNP symptoms. This finding highlights the possibility of developing an efficient, safe, and cost-effective therapy for patients with CRSwNP.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"313-318"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0