Acta Oto-Laryngologica最新文献_第7页

Construction of prediction model of early glottic cancer based on machine learning. 基于机器学习的早期声门癌预测模型构建。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-12-30 DOI: 10.1080/00016489.2024.2430613

Wang Zhao, Jingtai Zhi, Haowei Zheng, Jianqun Du, Mei Wei, Peng Lin, Li Li, Wei Wang

{"title":"Construction of prediction model of early glottic cancer based on machine learning.","authors":"Wang Zhao, Jingtai Zhi, Haowei Zheng, Jianqun Du, Mei Wei, Peng Lin, Li Li, Wei Wang","doi":"10.1080/00016489.2024.2430613","DOIUrl":"https://doi.org/10.1080/00016489.2024.2430613","url":null,"abstract":"Background: The early diagnosis of glottic laryngeal cancer is the key to successful treatment, and machine learning (ML) combined with narrow-band imaging (NBI) laryngoscopy provides a new idea for the early diagnosis of glottic laryngeal cancer.Objective: To explore the clinical applicability of the diagnosis of early glottic cancer based on ML combined with NBI.Material and methods: A retrospective study was conducted on 200 patients diagnosed with laryngeal mass, and the general clinical characteristics and pathological results of the patients were collected. Chi-square test and multivariate logistic regression analysis were used to explore clinical and laryngoscopic features that could potentially predict early glottic cancer. Afterward, three classical ML methods, namely random forest (RF), support vector machine (SVM), and decision tree (DT), were combined with NBI endoscopic images to identify risk factors related to glottic cancer and to construct and compare the predictive models.Results: The RF‑based model was found to predict more accurately than other methods and have a significant predominance over others. The accuracy, precision, recall and F1 index, and AUC value of the RF model were 0.96, 0.90, 1.00, 0.95, and 0.97.Conclusions and significance: We developed a prediction model for early glottic cancer using RF, which outperformed other models.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"145 1","pages":"72-80"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between NF-E2-related factor 2 polymorphism and age-related hearing loss in the general Japanese population from the Iwaki health promotion project. 来自Iwaki健康促进项目的nf - e2相关因子2多态性与日本普通人群年龄相关性听力损失之间的关系

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1080/00016489.2024.2435459

Takashi Kasai, Akira Sasaki, Shuya Kasai, Shiori Miura, Shinichi Goto, Ryoko Yotsuyanagi, Tatsuya Mikami, Yoshinori Tamada, Ken Itoh, Atsushi Matsubara

{"title":"Association between NF-E2-related factor 2 polymorphism and age-related hearing loss in the general Japanese population from the Iwaki health promotion project.","authors":"Takashi Kasai, Akira Sasaki, Shuya Kasai, Shiori Miura, Shinichi Goto, Ryoko Yotsuyanagi, Tatsuya Mikami, Yoshinori Tamada, Ken Itoh, Atsushi Matsubara","doi":"10.1080/00016489.2024.2435459","DOIUrl":"10.1080/00016489.2024.2435459","url":null,"abstract":"Background: Single-nucleotide polymorphisms (SNPs) of the NF-E2-related factor 2 (NRF2) gene might be associated with several diseases. In the animal models, NRF2 has been reported to be associated with the age-related hearing loss (ARHL). However, the effect of NRF2 SNPs on ARHL in the general population has not been reported.Objectives: This study aimed to evaluate the effect of NRF2 SNP-617 on ARHL in the general Japanese population.Methods: This study included participants from the Iwaki Health Promotion Project. The genotypes of NRF2 SNP-617 were determined via whole-genome sequencing, and the hearing level of the CC homozygote + CA heterozygote carrier group was compared with that of the AA homozygote carrier group.Results: Among the 306 CC+CA and 31 AA group male subjects, 22 (7.2%) and six (19.4%), respectively, had hearing loss, with a significant difference. Multiple logistic regression analysis showed that the risk of hearing loss in the male subjects was significantly higher in the AA group than that in the CC+CA group (p = .031, odds ratio = 3.437, 95% confidence interval = 1.116-10.580).Conclusion: The genotypes of NRF2 SNP-617 AA carriers were significantly associated with the development of ARHL among the males aged 30-59 years.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"36-42"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Squamous cell carcinoma of the temporal bone: the impact of local control on survival. 颞骨鳞状细胞癌：局部控制对生存的影响。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-02-12 DOI: 10.1080/00016489.2024.2311788

Antoine Dubray-Vautrin, Benjamin Vérillaud, Philippe Herman, Romain Kania

{"title":"Squamous cell carcinoma of the temporal bone: the impact of local control on survival.","authors":"Antoine Dubray-Vautrin, Benjamin Vérillaud, Philippe Herman, Romain Kania","doi":"10.1080/00016489.2024.2311788","DOIUrl":"10.1080/00016489.2024.2311788","url":null,"abstract":"Background: Squamous cell carcinoma (SCC) of the temporal bone (TB) is a rare pathology originating from the external auditory canal (EAC). Surgery remains the gold standard to achieve local control.Aims/Objectives:The aim of this study was to evaluate overall survival (OS) and disease-free survival (DFS) after surgery of the SCC of EAC.Material and methods: A retrospective chart review in a tertiary referral center included 26 patients: 23 were operated with lateral temporal bone resection (LTBR, n = 10) and extended temporal bone resection (ETBR, n = 13). The outcomes were OS and DFS.Results: Adjuvant radiotherapy was performed in 91.3% (n = 21/23). Mean age was 60.8 and sex ratio was 1. Median follow-up was 43 months; The 5-years OS was 90% (± 9.5%) and 47.7% (± 12.9%) for stage I/II and III/IV respectively (p = .033). DFS was 67.6% (IC 95%, 51.4%-88.9%) without statistical difference between early advanced stage. Incomplete margins (p = .004) and Stage IV(p < .001) were associated with poorer DFS. Free margins significantly correlated with better OS (HR = 9.8, p = .04).Conclusion: En bloc surgical resection with free margins, coupled with postoperative radiotherapy, provides optimal local control. For stage IV tumors, where complete margins are achievable, ETBR is recommended to enhance local control.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"23-29"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in the incidence and prevalence of juvenile-onset recurrent respiratory papillomatosis following implementation of national HPV vaccination initiatives: a systematic review. 在实施国家HPV疫苗接种计划后，青少年复发性呼吸道乳头状瘤病的发病率和流行趋势：一项系统综述。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.1080/00016489.2024.2431548

Ida-Marie Jacobsen, Amanda-Louise Fenger Carlander, Mathilde Aakilde, Christian von Buchwald

{"title":"Trends in the incidence and prevalence of juvenile-onset recurrent respiratory papillomatosis following implementation of national HPV vaccination initiatives: a systematic review.","authors":"Ida-Marie Jacobsen, Amanda-Louise Fenger Carlander, Mathilde Aakilde, Christian von Buchwald","doi":"10.1080/00016489.2024.2431548","DOIUrl":"10.1080/00016489.2024.2431548","url":null,"abstract":"Background: Infection with human papillomavirus (HPV) low-risk type 6 and 11 in the respiratory tract can cause recurrent benign squamous papillomas in the larynx, in children, juvenile-onset recurrent respiratory papillomatosis (JoRRP).Objectives: This systematic review investigated the impact of national HPV vaccination programs on JoRRP incidence and prevalence.Methods: PubMED was systematically searched for publications between 2010 and March 2024 that assessed the incidence and prevalence of JoRRP post-implementation of HPV vaccination programs.Results: Four studies met the inclusion criteria, comprising 622 patients with JoRRP (range 15-576) from Australia, New Zealand and the Unites States. The majority were girls (F:M ratio 2:1), with a median debut age between three to four years. Two studies (n = 591) showed a significant decline in JoRRP incidence after vaccination from 2,0 per 100,000 < 18 years (2004-2005) to 0,5 per 100,000 < 18 years (2012-2013) in the United States, and 0,16 per 100,000 < 15 years (2012) to 0,02 per 100,000 < 15 years (2016) in Australia. Higher vaccination coverage correlated with a reduced JoRRP burden.Conclusion: Our findings indicate implementation of HPV-vaccination programs reduced the JoRRP incidence and prevalence emphasizing the importance of large-scale HPV vaccination. Total impact of HPV vaccination will become fully evident when the vaccinated population reach childbearing ages.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"66-71"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymph node density as prognostic factor in regional recurrent or residual head and neck cancer. 淋巴结密度作为局部复发或残留头颈癌的预后因素。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.1080/00016489.2024.2432505

Seiya Goto, Hidenori Suzuki, Shintaro Beppu, Daisuke Nishikawa, Michi Sawabe, Hoshino Terada, Nobuhiro Hanai, Michihiko Sone

{"title":"Lymph node density as prognostic factor in regional recurrent or residual head and neck cancer.","authors":"Seiya Goto, Hidenori Suzuki, Shintaro Beppu, Daisuke Nishikawa, Michi Sawabe, Hoshino Terada, Nobuhiro Hanai, Michihiko Sone","doi":"10.1080/00016489.2024.2432505","DOIUrl":"10.1080/00016489.2024.2432505","url":null,"abstract":"Background: Prognostic factors from neck dissection for regional recurrent or residual head and neck cancer remain undetermined.Aims/objectives: We studied whether continuous variables from pathologic lymph nodes of salvage neck dissection could estimate survival outcomes in patients with head and neck squamous cell carcinomas (HNSCC).Materials and methods: Pathologic continuous variables from neck dissection without primary tumor resection in 184 patients with HNSCC were retrospectively evaluated. Cutoff values from both lymph node density (LND) and log odds of positive lymph nodes (LODDS) as the variables were applied to death estimation. Uni-/multivariate survival analyses adjusting for pathologic N classification and extranodal extension were evaluated by log-rank test or Cox's proportional hazard model, respectively.Results: LND ≥ 0.14 and LODDS ≥ -1.72 were significantly related to univariate shorter survival outcomes. Multivariate analysis indicated a significant association between LND ≥ 0.14 and shorter overall (hazard ratio [HR] = 2.16, 95% confidence interval [CI] = 1.30-3.58), local recurrence-free (HR = 2.34, 95% CI = 1.06-5.16), regional recurrence-free (HR = 2.32, 95% CI = 1.27-4.25), and distant metastasis-free survival (HR = 2.17, 95% CI = 1.31-3.61).Conclusions and significance: Based on the obtained results, increased LND was a poor prognostic factor following salvage neck dissection.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"81-87"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-surgical changes in wideband absorbance in paediatric cochlear implant users after mastoidectomy and posterior tympanotomy. 乳突切除和后鼓室切开术后儿童人工耳蜗使用者的术后宽带吸收变化。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-12-30 DOI: 10.1080/00016489.2024.2437552

Maraiah Mamatha Nerale, Bansode Rohit Raghunath, Arunraj Karuppannan

{"title":"Post-surgical changes in wideband absorbance in paediatric cochlear implant users after mastoidectomy and posterior tympanotomy.","authors":"Maraiah Mamatha Nerale, Bansode Rohit Raghunath, Arunraj Karuppannan","doi":"10.1080/00016489.2024.2437552","DOIUrl":"https://doi.org/10.1080/00016489.2024.2437552","url":null,"abstract":"Background: Although Cochlear implantation (CI) is effective in restoring hearing for children with severe-to-profound sensorineural hearing loss, it may influence the middle ear mechanics, potentially causing an air-bone gap and altering middle ear stiffness, which is not detected by traditional 226 Hz tympanometry.Aims/objectives: To investigate the effect of mastoidectomy posterior tympanotomy (MPTA) on wideband absorbance (WBA) in children with CI.Materials and methods: The study included 20 normal-hearing children (normal group) and 10 children with CIs who underwent MPTA (CI-MPTA group), aged 3-10 years. WBA at peak and ambient pressure, resonance frequency, and 226 Hz tympanometry were measured.Results: The normal group showed maximum absorbance at 1250 and 3000 Hz, whereas the CI-MPTA group had a single peak at 3000 Hz. The CI-MPTA group exhibited reduced absorbance at low and mid-frequencies (250-1500 Hz), with significant differences (p < 0.05) observed at 800-1250 Hz for peak pressure and 1000-1250 Hz for ambient pressure. No significant differences were found in resonance frequency or 226 Hz tympanometry.Conclusions and significance: CI with MPTA changes middle ear absorbance patterns, affecting the low- and mid-frequency regions. These findings indicate the importance of using WBA tympanometry to monitor middle and inner ear mechanics post-CI.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"145 1","pages":"43-50"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Somatic genetic alterations of oncogenes and tumor suppressor genes in cholesteatoma. 胆脂瘤中癌基因和抑癌基因的体细胞遗传改变。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-12-08 DOI: 10.1080/00016489.2024.2433138

Levent Şimşek, M Selman Yıldırım, Çağatay Han Ülkü, Ayşe Gül Zamani

{"title":"Somatic genetic alterations of oncogenes and tumor suppressor genes in cholesteatoma.","authors":"Levent Şimşek, M Selman Yıldırım, Çağatay Han Ülkü, Ayşe Gül Zamani","doi":"10.1080/00016489.2024.2433138","DOIUrl":"10.1080/00016489.2024.2433138","url":null,"abstract":"Background: Cholesteatoma is a proliferative disease that affects the tympanic cavity and temporal bone. Despite many studies and various theories, the etiopathogenesis of cholesteatoma has not been fully elucidated. Features such as invasion, migration, uncontrolled proliferation, and lack of differentiation are observed in both cholesteatoma and neoplasia.Aims/objectives: The aim of this study is to investigate somatic genetic alterations in known proto-oncogenes and tumor suppressor genes in cholesteatoma.Material and methods: 60 different known proto-oncogenes and tumor suppressor genes were comparatively analyzed in cholesteatoma and peripheric blood samples from 15 middle ear cholesteatoma patients using next-generation sequencing.Results: JAK3 c.2164G > A, TP53 c.284delC, and KRAS c.377A > T alterations were observed in cholesteatoma tissue but not in normal tissue. In addition, 12 different germline variants were also identified in 8 patients.Conclusions and significance: In this study, the presence of changes in cancer-related genes in cholesteatoma was determined and these changes were discussed in terms of possible clinical applications. We hope that the genetic alterations that emerged in this study, will be beneficial in guiding future research in this field.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"16-22"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between Lund-Mackay computed tomography score and subjective symptoms in Chinese patients with nasal polyps. 中国鼻息肉患者的 Lund-Mackay 计算机断层扫描评分与主观症状之间的相关性。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-10-21 DOI: 10.1080/00016489.2024.2412720

Qianqian Zhang, Chen Zhang, Jiani Chen, Le Shi, Yingqi Gao, Yumin Zhou, Fuying Cheng, Dehui Wang, Huan Wang, Xicai Sun, Li Hu

{"title":"Correlation between Lund-Mackay computed tomography score and subjective symptoms in Chinese patients with nasal polyps.","authors":"Qianqian Zhang, Chen Zhang, Jiani Chen, Le Shi, Yingqi Gao, Yumin Zhou, Fuying Cheng, Dehui Wang, Huan Wang, Xicai Sun, Li Hu","doi":"10.1080/00016489.2024.2412720","DOIUrl":"10.1080/00016489.2024.2412720","url":null,"abstract":"Background: The association between objective imaging findings and subjective symptoms remains undefined.Aims: To investigate the correlation between objective imaging findings and symptom severity in the overall chronic rhinosinusitis with nasal polyps (CRSwNP) population as well as its subendotypes according to the eosinophilic inflammation.Methods: Patients with CRSwNP undergoing endoscopic sinus surgery were included. All participants completed the Sino-Nasal Outcome Test (SNOT-22) questionnaire. The Lund-Mackay (LM) CT scores was also obtained. Spearman correlation analysis was performed to evaluate the correlation between CT scores and SNOT-22 scores.Results: Forty-four non-eosinophilic CRSwNP(neCRSwNP) and 93 eosinophilic CRSwNP (eCRSwNP) patients were recruited. There was significant association between LM total score and nasal subdomain of SNOT-22 in the overall CRSwNP patients. The nasal symptom of SNOT-22 was significantly associated with maxillary, frontal, sphenoid, anterior drainage, and posterior drainage in all CRSwNP patients. In eCRSwNP and neCRSwNP patients, the sense of smell/taste was associated with sphenoid and posterior drainage. Thick nasal discharge was positively correlated with maxillary, frontal, and anterior drainage only in eCRSwNP patients.Conclusions: The high score of sphenoid and posterior drainage may suggest the occurrence of loss of sense of smell/taste, while high score of maxillary sinus may indicate suffering from thick nasal discharge in eCRSwNP patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"59-65"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ototoxic effects of unilateral postauricular neomycin administration on the inner ears of Guinea pigs. 单侧耳后给药新霉素对豚鼠内耳的耳毒性作用。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1080/00016489.2024.2436076

Nishan Chen, Tongxiang Diao, Jilei Zhang, Lisheng Yu

{"title":"Ototoxic effects of unilateral postauricular neomycin administration on the inner ears of Guinea pigs.","authors":"Nishan Chen, Tongxiang Diao, Jilei Zhang, Lisheng Yu","doi":"10.1080/00016489.2024.2436076","DOIUrl":"10.1080/00016489.2024.2436076","url":null,"abstract":"Backgrounds: Due to the therapeutic needs of inner ear diseases, a simple method of inner ear drug delivery has been under exploration. Postauricular administration, which involves injecting the drug through the middle of the retroauricular groove, is a potential novel approach, but its mechanisms remain unclear.Objectives: To investigate threshold shifts in the auditory brainstem response (ABR), as well as the morphology and quantity of hair cells on the bilateral inner ear of guinea pigs after postauricular neomycin administration.Material and methods: Thirty healthy guinea pigs were divided randomly into two groups and administered either neomycin 200 mg/kg or saline 1 ml via daily postauricular injection for 10 days. Auditory threshold-shifts were examined by tests of the ABR. The quantity and morphology of hair cells in the organ of Corti were assessed by confocal laser scanning microscopy.Results: The ABR results showed that at a frequency of 16 kHz, the threshold shift was 21.00 ± 14.49 dB in the neomycin injection side, 10.00 ± 16.67 dB in the contralateral side, and 0.50 ± 3.69 dB in the saline group. At a frequency of 24 kHz, the threshold shift was 37.00 ± 16.36 dB in the neomycin injection side, 14.50 ± 9.26 dB in the contralateral side, and 1.00 ± 2.11 dB in the saline group. Histopathological analysis revealed that the outer hair cells (OHCs) in the neomycin injection side suffered significant morphological and numerical loss, while the OHC loss in the contralateral ear was less severe than in the injection side but greater than in the saline group.Conclusions and significance: This study confirms that postauricular administration is a novel method of local drug delivery to the inner ear, which has practical value in future experimental modeling and the treatment of inner ear diseases.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"93-100"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collaborative machine learning-guided overall survival prediction of oral squamous cell carcinoma. 以机器学习为指导的口腔鳞状细胞癌总体生存率协作预测。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-12-31 DOI: 10.1080/00016489.2024.2437012

Rasheed Omobolaji Alabi, Mohammed Elmusrati, Ilmo Leivo, Alhadi Almangush, Antti A Mäkitie

{"title":"Collaborative machine learning-guided overall survival prediction of oral squamous cell carcinoma.","authors":"Rasheed Omobolaji Alabi, Mohammed Elmusrati, Ilmo Leivo, Alhadi Almangush, Antti A Mäkitie","doi":"10.1080/00016489.2024.2437012","DOIUrl":"https://doi.org/10.1080/00016489.2024.2437012","url":null,"abstract":"Background: There is a lack of prognosticators of overall survival (OS) for Oral Squamous Cell Carcinoma (OSCC).Objectives: We examined collaborative machine learning (cML) in estimating the OS of OSCC patients. The prognostic significance of the clinicopathological parameters was examined.Methodology: Altogether, 9439 OSCC patients were extracted from the Surveillance, Epidemiology, and End Results database (US). Five ML models - voting ensemble, stacked ensemble, extreme gradient boosting, light boosting, and logistic regression were used to predict OS. Three of these ML algorithms were combined to form a cluster of cML models. The performance of the cML was compared with the best performing individual ML algorithm following model training.Results: The performance accuracy of the voting ensemble, stacked ensemble, extreme gradient boosting, light boosting, and logistic regression models was 70.2%, 69.9%, 69.1%, 69.4%, and 69.5% respectively, following model training. When the voting ensemble model was compared with cML using temporal validation, the cML showed a comparable performance accuracy. The most significant prognostic factors were age of the patient at diagnosis, T stage, tumor grade, marital status, gender, primary site, surgery, N stage, radiotherapy, ethnicity, chemotherapy, and M stage.Conclusions: cML appears to give reliability to the final prediction and thereby may mark a paradigm shift from model individualism to a more cooperative paradigm. This approach may aid in determining an enhanced individualized treatment for OSCC patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0