Acta Oto-Laryngologica最新文献_第7页

Impact of single versus multiple surgeries in CRSwNP patients undergoing treatment with dupilumab. 单次手术与多次手术对接受dupilumab治疗的CRSwNP患者的影响

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-23 DOI: 10.1080/00016489.2025.2481233

Matteo Alicandri-Ciufelli, Carla Cantaffa, Costanza Galloni, Ignazio Javier Fernandez, Daniele Marchioni, Carlotta Pipolo, Massimiliano Garzaro, Letizia Nitro, Valeria Dell'Era, Francesco Ferella, Massimo Campagnoli, Paolo Russo, Angelo Ghidini, Eugenio De Corso, Daniela Lucidi

{"title":"Impact of single versus multiple surgeries in CRSwNP patients undergoing treatment with dupilumab.","authors":"Matteo Alicandri-Ciufelli, Carla Cantaffa, Costanza Galloni, Ignazio Javier Fernandez, Daniele Marchioni, Carlotta Pipolo, Massimiliano Garzaro, Letizia Nitro, Valeria Dell'Era, Francesco Ferella, Massimo Campagnoli, Paolo Russo, Angelo Ghidini, Eugenio De Corso, Daniela Lucidi","doi":"10.1080/00016489.2025.2481233","DOIUrl":"10.1080/00016489.2025.2481233","url":null,"abstract":"Background: Prior to the introduction of biologic drugs, the natural history of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) was characterized by multiple recurrences, thus necessitating multiple surgical interventions.Aims/objectives: To understand whether Dupilumab efficacy in recurrent CRSwNP varies based on number of previous surgeries.Materials and methods: This is a multicentric retrospective study on patients with CRSwNP under Dupilumab, who underwent at least one previous surgery. Correlations between number of previous surgeries and clinical outcomes at baseline and during treatment were investigated.Results: 141 patients were included. Mean number of prior surgeries was 2.19 (median 2; range 1-13). For all patients, significant improvements were observed across all time points. Poorer results were observed in patients subjected to more than one prior surgery in terms of NPS at T2 (p .04), SNOT-22 at T4 (p .03), VAS for olfactory dysfunction at T3 (p .01) and T5 (p .009), VAS for nasal obstruction at T4 (p .047), VAS for rhinorrhea at T4 (p .02), VAS for craniofacial pain at T1 (p .02) and T2 (p .04) and of VAS for sleep disturbances at T1 (p .04).Conclusions and significance: Patients subjected to multiple surgeries have worse outcomes during treatment with Dupilumab, particularly for what concerns craniofacial pain and olfactory dysfunction.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"450-456"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minigene assay for verifying the splicing effects of the rare variants in the SLC12A2 gene at c.2930-1G>a. 验证SLC12A2基因中罕见变异体在c.2930-1G>a处剪接效应的迷你基因试验。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1080/00016489.2025.2475486

Lin Mengsi, Zhu Qingwen, Cui Aimin, Wang Jing

{"title":"Minigene assay for verifying the splicing effects of the rare variants in the SLC12A2 gene at c.2930-1G>a.","authors":"Lin Mengsi, Zhu Qingwen, Cui Aimin, Wang Jing","doi":"10.1080/00016489.2025.2475486","DOIUrl":"10.1080/00016489.2025.2475486","url":null,"abstract":"Background: Hearing loss (HL) is a prevalent sensory impairment with a genetic basis. The SLC12A2 gene, encoding NKCC1, is vital for inner ear ion balance. The c.2930-1G > A variant is a novel mutation potentially linked to sensorineural hearing loss.Objectives: To investigate the splicing and protein expression effects of the c.2930-1G>A variant in SLC12A2 and its role in hearing loss.Material and methods: Minigene assays and plasmid transfection in HEK-293T and Hela cells were used to study splicing. Protein expression and modification were also assessed.Results: The c.2930-1G>A variant caused partial exon skipping, altering mRNA splicing in both cell types. This suggests a potential involvement in sensorineural hearing loss. Protein analysis showed the E21del mutation increased expression without altering modification patterns, whereas the 2930_2977del mutation reduced both, possibly impacting stability or modification sites.Conclusions and significance: The c.2930-1G>A variant likely contribute to hearing loss by disrupting splicing and protein expression. Currently a Variant of Uncertain Significance (VUS), its pathogenicity is supported by these findings. Further research is needed to confirm its role, emphasizing the need for integrated genetic and clinical data in auditory disorders management.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"375-381"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of functional and aesthetic outcomes following open technique septorhinoplasty: assessing the utility and correlation of the Rhinoplasty Health Inventory and Nasal Outcomes, Rhinoplasty Outcome Evaluation, and Nasal Obstructive Symptom Evaluation questionnaires. 开放性鼻中隔成形术后功能和美学结果的评估：评估鼻整形健康量表和鼻结局、鼻整形结果评估和鼻阻塞症状评估问卷的效用和相关性

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI: 10.1080/00016489.2025.2477210

Gamze Ozturk Yilmaz, Gokhan Yilmaz

{"title":"Evaluation of functional and aesthetic outcomes following open technique septorhinoplasty: assessing the utility and correlation of the Rhinoplasty Health Inventory and Nasal Outcomes, Rhinoplasty Outcome Evaluation, and Nasal Obstructive Symptom Evaluation questionnaires.","authors":"Gamze Ozturk Yilmaz, Gokhan Yilmaz","doi":"10.1080/00016489.2025.2477210","DOIUrl":"10.1080/00016489.2025.2477210","url":null,"abstract":"Background: The importance of subjective quality of life questionnaires in evaluating post-rhinoplasty outcomes and patient satisfaction is increasing.Objective: This study aimed to measure the aesthetic and functional satisfaction of patients following septorhinoplasty using the Rhinoplasty Health Inventory and Nasal Outcomes (RHINO), Rhinoplasty Outcome Evaluation (ROE), and Nasal Obstructive Symptom Evaluation (NOSE) questionnaires.Methods: This prospective study included 306 patients who underwent a primary open-technique septorhinoplasty. The NOSE, ROE, and RHINO questionnaires were given to all patients before surgery and in the sixth month following surgery.Results: Preoperative NOSE, ROE, and RHINO scores significantly improved postoperatively in all patients (p < .001). Postoperative satisfaction was higher among young people, women, those with functional indications, single people, and those who were unemployed. Additionally, positive correlation existed between the RHINO and ROE scores (p < .001), and negative correlation existed between the postoperative RHINO and NOSE scores (p < .001).Conclusions: Thus, septorhinoplasty likely improves the functional and aesthetic quality of life in all patients. Our results suggest that a patient who scores favorable on the NOSE and ROE questionnaires is also likely to score favorable on the RHINO questionnaire.Significance: It is possible to evaluate septorhinoplasty results both functionally and aesthetically using just one questionnaire.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"443-449"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of surgical intervention for chronic suppurative otitis media in patients with hematologic diseases. 血液病合并慢性化脓性中耳炎的外科治疗效果评价。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1080/00016489.2025.2471940

Ai Wang, Qingfeng Li, Hongwei Zheng, Lin Han, Jinmei Xue, Lisheng Yu

{"title":"Evaluation of surgical intervention for chronic suppurative otitis media in patients with hematologic diseases.","authors":"Ai Wang, Qingfeng Li, Hongwei Zheng, Lin Han, Jinmei Xue, Lisheng Yu","doi":"10.1080/00016489.2025.2471940","DOIUrl":"10.1080/00016489.2025.2471940","url":null,"abstract":"Objective: To evaluate the effectiveness and safety of surgical treatment for chronic suppurative otitis media (CSOM) in patients with hematologic diseases.Methods: This retrospective study included 26 patients (16 males and 10 females; median age of 36.5 years) with CSOM and hematological diseases treated over three years. All patients received chemotherapy before surgery. Preoperative symptoms included hearing loss accompanied by intermittent ear discharge, ear pain, and dizziness, but no facial paralysis. Surgical indications were recurrent infections, invasive fungal otitis during chemotherapy, or planned hematopoietic stem cell transplantation. Based on the extent of the lesions and intraoperative conditions.Results: All surgeries were successful with a median duration of 70.5 (36-120) minutes and intraoperative blood loss of < 20 mL, without postoperative complications. Hospital stay averaged 9 (8-15) days. During the 6-24-month follow-up, one patient experienced a recurrence of CSOM, and one died from worsening hematologic disease. The remaining patients recovered well and continued to receive appropriate hematologic treatment.Conclusions: Surgical treatment is a safe and effective option for patients with CSOM and hematologic diseases. It can improve patient outcomes and facilitate ongoing and subsequent hematologic cure.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"390-394"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of polysomnography data and inflammatory markers after sleep surgery. 睡眠手术后多导睡眠图数据与炎症标志物的相关性。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1080/00016489.2025.2470304

Öznur Gündüz, Şeyda Akbal Çufalı

{"title":"Correlation of polysomnography data and inflammatory markers after sleep surgery.","authors":"Öznur Gündüz, Şeyda Akbal Çufalı","doi":"10.1080/00016489.2025.2470304","DOIUrl":"10.1080/00016489.2025.2470304","url":null,"abstract":"Background: The occurrence of hypoxia during apneas and hypopneas is associated with the triggering of an inflammatory response.Objectives: This study investigates the alterations in polysomnography (PSG) data, inflammatory markers, and the correlation between these alterations in patients undergoing sleep surgery.Methods: The data of 66 patients who underwent drug-induced sleep endoscopy followed by appropriate sleep surgery, with follow-up PSG performed at 3 to 6 months postoperatively, were retrospectively analyzed. Additionally, correlations with inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), eosinophil-to-lymphocyte ratio (ELR) and systemic immune-inflammation index (SII), were investigated.Results: Comparison of preoperative and postoperative inflammatory markers revealed statistically significant reductions in NLR, PLR, and SII (p < 0.001, p = 0.023, p = 0.026, respectively). Significant positive correlations were identified between AHI and NLR (p = 0.001, r = 0.400), PLR (p = 0.001, r = 0.415) and SII (p = 0.010, r = 0.392). Similarly, a significant positive correlation was observed between supine AHI and NLR (p = 0.035, r = 0.379), PLR (p = 0.008, r = 0.325), and SII (p = 0.030, r = 0.367). The time spent with SaO2 below 90% was found to be significantly and positively correlated with NLR (p = 0.023, r = 0.279), PLR (p = 0.027, r = 0.272), and SII (p = 0.033, r = 0.256).Conclusions and significance: A correlation was observed between the postoperative decrease in SII, NLR, and PLR values and PSG data in patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"457-462"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Audiological findings in patients with leprosy. 麻风病患者的听力学发现。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1080/00016489.2025.2482170

Mahmut Uzut, Senem Erdur Uzut, Fatma Tülin Kayhan, Levent Küfeciler, Zübeyde Elmalı

{"title":"Audiological findings in patients with leprosy.","authors":"Mahmut Uzut, Senem Erdur Uzut, Fatma Tülin Kayhan, Levent Küfeciler, Zübeyde Elmalı","doi":"10.1080/00016489.2025.2482170","DOIUrl":"10.1080/00016489.2025.2482170","url":null,"abstract":"Background: Leprosy, caused by Mycobacterium leprae, is a chronic infectious disease primarily affecting the skin and nervous system. The vestibulocochlear nerve may also be impacted, potentially leading to auditory dysfunction.Aims/objectives: This study investigates the effects of leprosy on the vestibulocochlear nerve and its impact on auditory function through a comprehensive audiological evaluation.Material and methods: A total of 15 leprosy patients and 15 healthy individuals were included. Audiological assessments were conducted at a tertiary care hospital. All participants underwent pure-tone audiometry, speech audiometry, tympanometry, acoustic reflex testing, otoacoustic emissions (OAE), and brainstem auditory evoked response (BERA) tests. Hearing thresholds, wave latencies, and neural conduction were analyzed.Results: Hearing thresholds were significantly higher in leprosy patients than in the control group. BERA results showed a significant prolongation of wave I and wave III latencies in leprosy patients, indicating dysfunction at the level of the acoustic nerve and superior olivary complex.Conclusions and significance: Leprosy may contribute to auditory dysfunction by affecting the myelin sheath of the peripheral and central nervous systems. These findings provide insight into the impact of leprosy on the vestibulocochlear nerve and emphasize the importance of audiological evaluation in leprosy patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"395-399"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the role of vestibular function in motion sickness and visually induced motion sickness by multiple vestibular function tests. 通过多次前庭功能试验探讨前庭功能在晕动病和视动病中的作用。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-16 DOI: 10.1080/00016489.2025.2486609

Jing Zhao, Linyao Shi, Xiaoming Li, Chuanxia Cao, Qikun Zhang, Chuanjing Qiu, Jiamei Lu, Shuai Pan, Jing Xue, Zhanguo Jin, Shengguang Yan

{"title":"Investigating the role of vestibular function in motion sickness and visually induced motion sickness by multiple vestibular function tests.","authors":"Jing Zhao, Linyao Shi, Xiaoming Li, Chuanxia Cao, Qikun Zhang, Chuanjing Qiu, Jiamei Lu, Shuai Pan, Jing Xue, Zhanguo Jin, Shengguang Yan","doi":"10.1080/00016489.2025.2486609","DOIUrl":"https://doi.org/10.1080/00016489.2025.2486609","url":null,"abstract":"Background: Motion sickness (MS) and visually induced motion sickness (VIMS) are vestibular system-related conditions affecting balance.Objectives: To investigate the role of vestibular function and susceptibility in MS/VIMS in healthy college students and to evaluate the effectiveness of various vestibular function tests in detecting these disorders.Materials and methods: Five hundred young adults, grouped by motion sickness susceptibility questionnaire-short (MSSQ-S) and visually induced motion sickness susceptibility questionnaire-short (VIMSSQ-S) questionnaires, were further analyzed via continuous linear regression to validate the grouping strategy. The participants completed a caloric test (CT), video head impulse test (vHIT), dynamic visual acuity (DVA), subjective visual vertical/horizontal (SVV/SVH), and sensory organisation tests (SOT). Analysis of the relationship between the results of the five tests and the MS/VIMS.Results: CT revealed significant differences in right cold slow-phase velocity (RC SPV) and left cold slow-phase velocity (LC SPV) among groups (p < 0.001), with strong correlations between these values and MS/VIMS susceptibility (p < 0.05). Among 52 subjects with abnormal CT results, significant differences were found in vHIT, DVA, and SOT (p < 0.001), while SVV/SVH showed a significant difference only in MSSQ-S scores (p = 0.034).Conclusions and significance: This study comprehensively assessed vestibular function in MS and VIMS susceptible individuals, confirming increased sensitivity and highlighting the need for targeted evaluation strategies.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-10"},"PeriodicalIF":1.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic, survival, and tumor control outcomes of parapharyngeal space liposarcoma: a systematic review. 咽旁间隙脂肪肉瘤的诊断、生存和肿瘤控制结果：一项系统综述。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1080/00016489.2025.2462688

Srivatsa Surya Vasudevan, Estephania Candelo, Tiba Yamin Kandrikar, Jeffrey R Janus

{"title":"Diagnostic, survival, and tumor control outcomes of parapharyngeal space liposarcoma: a systematic review.","authors":"Srivatsa Surya Vasudevan, Estephania Candelo, Tiba Yamin Kandrikar, Jeffrey R Janus","doi":"10.1080/00016489.2025.2462688","DOIUrl":"10.1080/00016489.2025.2462688","url":null,"abstract":"Background: Parapharyngeal space liposarcomas (PPS-LS) are rare tumors often associated with a moderate-to-poor prognosis.Objectives: This study aims to assess tumor control and survival outcomes across the various subtypes of PPS-LS.Material and methods: We conducted a systematic review of cases using PubMed, OVID, Scopus, Web of Science, ScienceDirect, and EBSCO from inception to October 2024. Given the data on individual patient follow-up, Kaplan-Meier survival analysis was utilized to calculate disease-free survival (DFS) and disease-specific survival (DSS).Results: Out of 303 articles, 10 studies with 11 patients (72.7% male) met the inclusion criteria, with a mean age of 51.3 years (range: 12-77.5). Preoperative fine needle aspiration cytology was conducted in 45.4%, with 80% yielding inconclusive results. The 2-year and 5-year DFS rates for PPS-LS were 64% and 50%, respectively, while the 2-year DSS rate was 84%. Tumor recurrence occurred in 36.3% of patients, with an average of 2.5 recurrences per patient, specifically the myxoid subtype of PPS-LS.Conclusion: This systematic review highlights the varied prognostic outcomes of PPS-LS and its subtypes, emphasizing the need for vigilant surveillance to improve DFS and reduce recurrence rates.Significance: This provides surgeons with critical insights into probable prognostic outcomes when dealing with specific subtypes of PPS-LS.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"348-354"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of nasal microplastic densities in patients with acute and chronic rhinitis. 急慢性鼻炎患者鼻腔微塑性密度的评价。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1080/00016489.2025.2468396

Ayşegül Tuna, Yeşim İtmeç, Birgül Kaçmaz, Serdar Gül, Sedat Kaygusuz

{"title":"Evaluation of nasal microplastic densities in patients with acute and chronic rhinitis.","authors":"Ayşegül Tuna, Yeşim İtmeç, Birgül Kaçmaz, Serdar Gül, Sedat Kaygusuz","doi":"10.1080/00016489.2025.2468396","DOIUrl":"10.1080/00016489.2025.2468396","url":null,"abstract":"Background: Increasing plastic consumption has made microplastics a persistent environmental pollutant present in the atmosphere and other ecosystems. These particles can enter biological tissues via ingestion, skin contact, or inhalation and potentially cause rhinitis and other respiratory diseases through inflammatory and cytotoxic effects.Objectives: This study evaluated the association between nasal inhalation of microplastics, a contributor to air pollution, and rhinitis symptoms, as well as their role in the etiology of acute and chronic rhinitis.Materials and methods: Sixty patients were equally divided into two groups: acute rhinitis (30 patients) and chronic rhinitis (30 patients). Demographic data, including age and gender, and total nasal symptom scores were recorded. Nasal lavage samples were collected and the number of microplastics in these samples was analyzed. Groups were compared based on microplastic counts.Results: The acute rhinitis group had significantly higher microplastic levels than the chronic rhinitis group. Microplastics were detected in at least one sample from each participant, regardless of gender, age, or symptom score.Conclusions and significance: The higher concentration of microplastics in acute rhinitis highlights their potential role in exacerbations and underscores the need for preventive strategies and further research on their long-term health effects.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"308-312"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gap-induced inhibition of the post-auricular muscle response in miniature pigs. 缝隙诱导的对小型猪耳后肌肉反应的抑制。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1080/00016489.2025.2464698

Hanwen Zhou, Peng Liu, Chi Zhang, Xinmiao Xue, Xuemin Chen, Zhixin Zhang, Weidong Shen, Shiming Yang, Mengyun Fan, Fangyuan Wang

{"title":"Gap-induced inhibition of the post-auricular muscle response in miniature pigs.","authors":"Hanwen Zhou, Peng Liu, Chi Zhang, Xinmiao Xue, Xuemin Chen, Zhixin Zhang, Weidong Shen, Shiming Yang, Mengyun Fan, Fangyuan Wang","doi":"10.1080/00016489.2025.2464698","DOIUrl":"10.1080/00016489.2025.2464698","url":null,"abstract":"Background: Tinnitus, a persistent condition that significantly impairs the quality of life for patients, poses a substantial burden on society. Owing to its complex and poorly understood pathogenesis, the development of effective animal models for tinnitus is imperative to enhance our comprehension of this condition.Objectives: The present study aims to establish a large animal model to delineate the mechanisms underlying the onset of tinnitus.Materials and methods: For the first time, we conducted a comparative analysis of the Post-Auricular Muscle Response (PAMR) and the Eye Blink Response (EBR) in miniature pigs, demonstrating their utility in manifesting Gap Prepulse Inhibition of the Acoustic Startle (GPIAS). Subsequently, we employed the gap-induced inhibition of PAMR to ascertain evidence of tinnitus following noise exposure.Results and conclusion: Through comparing the efficacy of PAMR and EBR in GPIAS detection, we have substantiated that PAMR provides a stable and objective reflection of GPIAS. Consequently, PAMR emerges as a reliable method for measuring GPIAS in miniature pigs. Furthermore, the behavioral paradigm of gap-induced inhibition of PAMR successfully identified behavioral evidence of tinnitus subsequent to noise exposure.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"291-298"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0