Acta Oto-Laryngologica最新文献_第7页

Association between hearing loss and trauma based on population data of Korea. 基于韩国人口数据的听力损失与创伤之间的关系。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2204116

Junhui Jeong, Hyunsun Lim, Hyun Seung Choi

{"title":"Association between hearing loss and trauma based on population data of Korea.","authors":"Junhui Jeong, Hyunsun Lim, Hyun Seung Choi","doi":"10.1080/00016489.2023.2204116","DOIUrl":"https://doi.org/10.1080/00016489.2023.2204116","url":null,"abstract":"Background: Although several studies have been conducted to assess the association between hearing loss (HL) and trauma, no studies have analyzed trauma comprehensively based on population-based data.Objectives: To investigate the association between HL and trauma in daily life using National Health Insurance Service National Sample Cohort data of Korea.Materials and methods: People who were registered with severe or mild hearing disability by the Korean government from 2002 to 2015, were included in this study. Trauma was defined as an outpatient visit or admission under diagnostic codes associated with trauma. The risk for trauma was analyzed using multiple logistic regression model.Results: There were 5,114 subjects in the mild hearing disability group and 1,452 in the severe hearing disability group. The risk for trauma was significantly higher in the mild and severe hearing disability groups than in the control group. The risk was higher in the mild hearing disability group than in the severe hearing disability group.Conclusions and significance: Individuals with hearing disability are at a higher risk for trauma based on population-based data in Korea, which indicates that HL increases the risk for trauma.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"392-395"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9900813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic observation of pharyngeal mucosal suture healing process after total laryngectomy: case series. 喉全切除术后咽黏膜缝合愈合过程的内镜观察:病例系列。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2203700

Shin Matsumoto, Masahiro Nakayama, Keitaro Fujii, Masahiro Adachi, Yoshihide Shima, Keiji Tabuchi

{"title":"Endoscopic observation of pharyngeal mucosal suture healing process after total laryngectomy: case series.","authors":"Shin Matsumoto, Masahiro Nakayama, Keitaro Fujii, Masahiro Adachi, Yoshihide Shima, Keiji Tabuchi","doi":"10.1080/00016489.2023.2203700","DOIUrl":"https://doi.org/10.1080/00016489.2023.2203700","url":null,"abstract":"Background: Pharyngocutaneous fistula (PCF), a major complication of total laryngectomy, is caused by pharyngeal repair failure.Objective: Assess the usefulness of endoscopic observation of the pharyngeal suture's healing process for the early detection of PCF development.Methods: Pharyngeal mucosal sutures were endoscopically observed postoperatively in patients who underwent total laryngectomy with primary closure.Results: Postoperatively, a white coat adhered to the pharyngeal mucosal suture of all patients. In most cases, the white coat gradually receded, which was considered to be a normal healing process. Thickening of the white coat and/or dehiscence of surgical wound were interpreted as 'poor healing conditions'. Three cases were judged to have developed poor healing conditions of the pharyngeal mucosal suture and one patient developed PCF. The other two patients did not develop PCF, possibly due to early detection of 'poor healing condition' and conservative approach, such as discontinuation of oral intake.Conclusions: Postoperative poor healing conditions of the pharyngeal mucosal suture may be precursors to PCF development. Endoscopic observation enables early detection of these conditions and may enable the prevention of PCF.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"434-439"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9530063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management and outcome of adenoid cystic carcinoma of the major salivary glands: the 22-year experience of a single institution. 大唾液腺腺样囊性癌的处理和结果:一个机构22年的经验。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2220371

Akiko Ozaki, Ryo Kawata, Ichita Kinoshita, Masaaki Higashino, Tetsuya Terada, Shin-Ichi Haginomori, Yoshitaka Kurisu, Yoshinobu Hirose

{"title":"Management and outcome of adenoid cystic carcinoma of the major salivary glands: the 22-year experience of a single institution.","authors":"Akiko Ozaki, Ryo Kawata, Ichita Kinoshita, Masaaki Higashino, Tetsuya Terada, Shin-Ichi Haginomori, Yoshitaka Kurisu, Yoshinobu Hirose","doi":"10.1080/00016489.2023.2220371","DOIUrl":"https://doi.org/10.1080/00016489.2023.2220371","url":null,"abstract":"Background: Prognostic factors and survival rate are difficult to determine for adenoid cystic carcinoma(AdCC) of salivary glands.Aims/objectives: To clarify the clinical characteristics of AdCC and examine factors associated with recurrence and prognosis by histopathological grade classification.Materials and methods: Twenty-five patients with AdCC of the parotid gland and 10 patients with AdCC of the submandibular gland were included. We classified AdCC histopathologically by the proportion of solid components. Clinical features, fine-needle aspiration cytology (FNAC), and patient outcomes were examined according to grade. Factors associated with local recurrence and distant metastases were examined.Results: Age was significantly higher in the grade III group than in the grade I group. The grade III group had significantly higher proportions of patients with cN+, pN+, and perineural invasion. In FNAC, lower-grade groups showed higher rates of correct histopathological type. Five-year disease-specific survival and disease-free survival rates were significantly lower in the grade III than in the grade I. Distant metastases were more common among patients with high-stage and perineural invasion.Conclusions: Five-year survival is significantly worse in patients with grade III.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 6","pages":"536-542"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9794946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can pepsin immunohistochemical staining of laryngeal lesions accurately diagnose non-acid laryngeal reflux? 喉病变胃蛋白酶免疫组化染色能准确诊断非酸性喉返流吗?

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2221694

Jiasen Wang, Jinrang Li, Jing Zhao, Jing Wu

{"title":"Can pepsin immunohistochemical staining of laryngeal lesions accurately diagnose non-acid laryngeal reflux?","authors":"Jiasen Wang, Jinrang Li, Jing Zhao, Jing Wu","doi":"10.1080/00016489.2023.2221694","DOIUrl":"https://doi.org/10.1080/00016489.2023.2221694","url":null,"abstract":"Background: Non-acid reflux is the most common form of laryngopharyngeal reflux (LPR). However, the damage caused by non-acid reflux to the laryngeal mucosa is weaker than that caused by acid reflux.Aims: To evaluate whether pepsin immunohistochemical (IHC) staining of laryngeal lesions can accurately diagnose acidic and non-acidic LPR.Materials and methods: Hypopharyngeal-esophageal multichannel intraluminal impedance-pH monitoring was performed, and the patients were divided into acid reflux and non-acid reflux groups. Pathological sections of laryngeal lesions were examined using pepsin IHC staining, which was positive when pepsin was detected in the cytoplasm.Results: The study included 136 patients, with 58 in the acid reflux group, 43 in the non-acid reflux group, and 35 in the without reflux group. There were no significant differences in the positive rate of pepsin IHC staining between the non-acid and acid reflux groups (p = .421). The sensitivity of pepsin IHC staining for the diagnosis of acid and non-acid reflux was 94.8% and 90.7%, respectively.Conclusions: The sensitivity of pepsin IHC staining for laryngeal lesions in the diagnosis of non-acidic LPR is satisfactory.Significance: Pepsin IHC staining is suitable for LPR screening of patients with laryngeal lesions as it is economical, non-invasive, and highly sensitive.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 6","pages":"524-527"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9797570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPV16 status might correlate to increasing tumor-infiltrating lymphocytes in hypopharyngeal cancer. HPV16状态可能与下咽癌中肿瘤浸润淋巴细胞的增加有关。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2221288

Mengyou Ji, Lan Lin, Qiang Huang, Chunyan Hu, Ming Zhang

{"title":"HPV16 status might correlate to increasing tumor-infiltrating lymphocytes in hypopharyngeal cancer.","authors":"Mengyou Ji, Lan Lin, Qiang Huang, Chunyan Hu, Ming Zhang","doi":"10.1080/00016489.2023.2221288","DOIUrl":"https://doi.org/10.1080/00016489.2023.2221288","url":null,"abstract":"Background: Human papillomavirus (HPV) plays a major etiological role in the increasing number of patients with head and neck squamous cell carcinoma (HNSCC).Objectives: This study aimed at exploring the relationship between HPV infection and prognosis in patients with hypopharyngeal carcinoma (HPSCC).Methods: We retrospectively analyzed 108 consecutive patients diagnosed with HPSCC from 2015 to 2018. Real-time fluorescent quantitative PCR and P16 immunohistochemistry were used to detect HPV infection in tissues of patients with hypopharyngeal carcinoma. The numbers of CD8, CD4 and Foxp3 cells in tumor parenchyma were obtained by immunohistochemical counting. Finally, the analysis was performed according to the clinicopathological variables and prognosis of the patients.Results: Among 108 patients with HPSCC, 18 cases were detected by qPCR, and 16 subtypes accounted for the majority (77.8%). Kaplan-Meier analysis showed that HPV16+, higher CD8+, higher CD4+ and higher FoxP3+ TIL infiltration was strongly associated with superior three-year disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS). Univariate analysis showed that HPV and CD4+ TIL had higher predictive value for prognosis.Conclusions: HPV16 infection is significantly related to tumor immune infiltrating cells (TILs).","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 6","pages":"543-550"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10174927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Preoperative factors influencing the rate and speed of available communication ability in prelingual paediatric cochlear implantation recipients. 影响语前儿童人工耳蜗植入受者有效沟通能力的术前因素。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2220755

Hui-Ru Fan, Dan Li, Shan-Hong Wang, Wei-Jia Kong

{"title":"Preoperative factors influencing the rate and speed of available communication ability in prelingual paediatric cochlear implantation recipients.","authors":"Hui-Ru Fan, Dan Li, Shan-Hong Wang, Wei-Jia Kong","doi":"10.1080/00016489.2023.2220755","DOIUrl":"https://doi.org/10.1080/00016489.2023.2220755","url":null,"abstract":"Background: Few studies have assessed factors influencing the rate and speed of good outcomes in cochlear implantation (CI) children.Objective: To analyse the factors influencing the rate and speed of available communication in CI children.Material and methods: The study involved 316 children. The categories of auditory performance (CAP) and speech intelligibility rating (SIR) were used to evaluate outcomes. Multivariable proportional Cox regression models were established to analyse the effect of preoperative factors.Results: Five variables were entered into the three multivariable models of CAP ≥6, SIR ≥4 and concurrent CAP ≥6 and SIR ≥4. Older age at implantation was a significant poor factor in the three models with estimated hazard ratios (HRs) of .541, .629, and .554, respectively. Another negative factor was poor parental literacy for the three outcomes (HR .639, .638, and .542, respectively). More than 3 months of rehabilitation from institutes had a positive effect on CAP ≥6 and concurrent CAP ≥6 and SIR ≥4 (HR 1.626 and 1.667, respectively).Conclusions and significance: Older age at implantation and poor parental literacy were negative factors. Receiving regular rehabilitation from institutes pre-CI could help the children gain available communication ability earlier on.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 6","pages":"481-488"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9788713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-exome sequencing for screening noise-induced hearing loss susceptibility genes. 全外显子组测序筛选噪声性听力损失易感基因。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2201287

Boya Fan, Gang Wang, Gang Liu, Xiaoli Zhang, Wei Wu

{"title":"Whole-exome sequencing for screening noise-induced hearing loss susceptibility genes.","authors":"Boya Fan, Gang Wang, Gang Liu, Xiaoli Zhang, Wei Wu","doi":"10.1080/00016489.2023.2201287","DOIUrl":"https://doi.org/10.1080/00016489.2023.2201287","url":null,"abstract":"Background: High-throughput sequencing of genes indicating susceptibility to noise-induced hearing loss has not previously been reported.Aims/objectives: To identify and analyze genes associated with susceptibility to noise-induced hearing loss (NIHL) and characterize differences in susceptibility to hearing loss by genotype.Material and methods: Pure tone audiometry tests were performed on 113 workers exposed to high-intensity noise. Whole-exome sequencing (WES) was conducted and NIHL susceptibility genes screened for training unsupervised and supervised machine learning models. Immunofluorescence staining of mouse cochlea was used to observe patterns of NIHL susceptibility gene expression.Results: Participants were divided into a NIHL and a control group, according to the results of audiometry tests. Seventy-three possible NIHL susceptibility genes were input into the machine learning model. Two subgroups of NIHL could be distinguished by unsupervised machine learning and the classification was evaluated by the supervised machine learning algorithm. The VWF gene had the highest mutation frequency in the NIHL group and was expressed mainly in the spiral ligament.Conclusions and significance: NIHL susceptibility genes were screened and NIHL subgroups could be distinguished. VWF may be a novel NIHL susceptibility gene.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"408-415"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9884239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncological and functional outcomes of partial or total laryngopharyngectomy for hypopharyngeal cancer with thyroid or cricoid cartilage invasion. 部分或全部喉咽切除术治疗甲状腺或环状软骨侵犯的下咽癌的肿瘤和功能结果。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2205443

Kwang-Jae Cho, Min-Sik Kim, Jung-Hae Cho, Jun-Ook Park, In-Chul Nam, Chung-Soo Kim, Young-Hoon Joo

{"title":"Oncological and functional outcomes of partial or total laryngopharyngectomy for hypopharyngeal cancer with thyroid or cricoid cartilage invasion.","authors":"Kwang-Jae Cho, Min-Sik Kim, Jung-Hae Cho, Jun-Ook Park, In-Chul Nam, Chung-Soo Kim, Young-Hoon Joo","doi":"10.1080/00016489.2023.2205443","DOIUrl":"https://doi.org/10.1080/00016489.2023.2205443","url":null,"abstract":"Background: Patients with cartilage invasion in hypopharyngeal squamous cell carcinoma (HPSCC) would benefit from partial laryngopharyngectomy (PLP).Aims/objectives: The purpose of this study was to examine the treatment outcomes of PLP for HPSCC with cartilage invasion, with a focus on the oncological safety and the function preservation.Materials and methods: We performed a retrospective review of 28 patients with HPSCC with thyroid or cricoid cartilage invasion who had undergone upfront surgery and were followed for more than one year between 1993 and 2019.Results: Twelve patients treated with PLP (42.9%) and 16 patients treated with total laryngopharyngectomy (TLP) for cartilage invasion in HPSCC were identified. There was no significant difference in recurrence between the PLP group (7/12, 58.3%) and the TLP group (8/16, 50.0%) (p = .718). PLP was not associated with decreased five-year disease free survival (p = .662) or disease specific survival (p = .883) rates compared to TLP. Nine patients receiving PLP could be decannulated and retained intelligible speech (9/12, 75%). Gastrostomy tubes were placed in the PLP group (5/12, 42.9%) and TLP group (1/16, 6.2%) (p = .057).Conclusions and significance: PLP appears to be a feasible option for the treatment of thyroid or cricoid cartilage invasion in HPSCC.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"429-433"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9529215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dynamic posturography after computerized vestibular retraining for stable unilateral vestibular deficits. 计算机前庭再训练后动态体位照相治疗稳定的单侧前庭功能缺损。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2208615

Eytan A David, Navid Shahnaz

{"title":"Dynamic posturography after computerized vestibular retraining for stable unilateral vestibular deficits.","authors":"Eytan A David, Navid Shahnaz","doi":"10.1080/00016489.2023.2208615","DOIUrl":"https://doi.org/10.1080/00016489.2023.2208615","url":null,"abstract":"Background: Balance deficits increase the risk of falls and compromise quality of life. Current treatment modalities do not resolve symptoms for many patients.Aims/objectives: To measure changes in objective posturography after a computerized vestibular retraining therapy protocol.Materials and methods: This was a single-arm interventional study of individuals with a stable unilateral vestibular deficit present for greater than six months. Participants underwent 12 twice-weekly sessions of computerized vestibular retraining therapy. Objective response was measured by the Sensory Organization Test and questionnaires were administered to measure subjective changes.Results: We enrolled 13 participants (5 females and 8 males) with a median age of 51 years (range 18 to 67). After retraining, the Sensory Organization Test composite score improved by 8.8 (95% CI 0.6 to 19.1) and this correlated with improvement in the Falls Efficacy Scale-International questionnaire (rs -0.6472; 95% CI -0.8872 to - 0.1316). Participants with moderate-to-severe disability at baseline (n = 7) demonstrated greater improvement in the composite score (14.6; 95% CI 7.0 to 36.9).Conclusions and significance: Computerized vestibular retraining therapy for stable unilateral vestibular deficits is associated with improvement in dynamic balance performance. Posturography improvements correlated with a reduction in perceived fall risk. Trial Registration Information Clinicaltrials.gov registration NCT04875013; 04/27/2021.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"396-401"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9604801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Neuromuscular retraining therapy combined with preceding botulinum toxin A injection for chronic facial paralysis. 神经肌肉再训练联合A型肉毒杆菌毒素注射治疗慢性面瘫。

IF 1.4 4区医学

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI: 10.1080/00016489.2023.2207599

Junhui Jeong, Jeon Mi Lee, Jin Kim

{"title":"Neuromuscular retraining therapy combined with preceding botulinum toxin A injection for chronic facial paralysis.","authors":"Junhui Jeong, Jeon Mi Lee, Jin Kim","doi":"10.1080/00016489.2023.2207599","DOIUrl":"https://doi.org/10.1080/00016489.2023.2207599","url":null,"abstract":"Background: Neuromuscular retraining therapy (NMRT) is the central treatment for synkinesis. The efficacy of botulinum toxin type A (BTX-A) may be enhanced with the addition of physical therapy.Objectives: To investigate the effects of NMRT combined with preceding BTX-A injection (NMRT-B) on facial synkinesis and asymmetry in chronic facial paralysis.Materials and methods: We recruited 99 patients with unilateral facial paralysis and no recovery for > 6 months who underwent NMRT-B for > 1 year. The patients were scheduled to receive NMRT after 1-2 weeks of BTX-A injection. We used a computer-based numerical scoring system to evaluate the facial functions. Primary, secondary, and final facial movement scores were evaluated before and after 1 year of treatment.Results: Patients with chronic facial paralysis who underwent NMRT-B exhibited improved facial movement after 1 year of treatment. NMRT-B provided satisfactory control of synkinesis and improved the primary movements. The mean primary and final facial movement scores were significantly increased after treatment, while the mean secondary facial movement scores were significantly decreased.Conclusions and significance: NMRT-B improved the final facial movement in patients with chronic facial paralysis and synkinesis, regardless of the degrees of facial synkinesis and asymmetry before treatment.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 5","pages":"446-451"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9901354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1