{"title":"睡眠手术后多导睡眠图数据与炎症标志物的相关性。","authors":"Öznur Gündüz, Şeyda Akbal Çufalı","doi":"10.1080/00016489.2025.2470304","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The occurrence of hypoxia during apneas and hypopneas is associated with the triggering of an inflammatory response.</p><p><strong>Objectives: </strong>This study investigates the alterations in polysomnography (PSG) data, inflammatory markers, and the correlation between these alterations in patients undergoing sleep surgery.</p><p><strong>Methods: </strong>The data of 66 patients who underwent drug-induced sleep endoscopy followed by appropriate sleep surgery, with follow-up PSG performed at 3 to 6 months postoperatively, were retrospectively analyzed. Additionally, correlations with inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), eosinophil-to-lymphocyte ratio (ELR) and systemic immune-inflammation index (SII), were investigated.</p><p><strong>Results: </strong>Comparison of preoperative and postoperative inflammatory markers revealed statistically significant reductions in NLR, PLR, and SII (<i>p</i> < 0.001, <i>p</i> = 0.023, <i>p</i> = 0.026, respectively). Significant positive correlations were identified between AHI and NLR (<i>p</i> = 0.001, <i>r</i> = 0.400), PLR (<i>p</i> = 0.001, <i>r</i> = 0.415) and SII (<i>p</i> = 0.010, <i>r</i> = 0.392). Similarly, a significant positive correlation was observed between supine AHI and NLR (<i>p</i> = 0.035, <i>r</i> = 0.379), PLR (<i>p</i> = 0.008, <i>r</i> = 0.325), and SII (<i>p</i> = 0.030, <i>r</i> = 0.367). The time spent with SaO<sub>2</sub> below 90% was found to be significantly and positively correlated with NLR (<i>p</i> = 0.023, <i>r</i> = 0.279), PLR (<i>p</i> = 0.027, <i>r</i> = 0.272), and SII (<i>p</i> = 0.033, <i>r</i> = 0.256).</p><p><strong>Conclusions and significance: </strong>A correlation was observed between the postoperative decrease in SII, NLR, and PLR values and PSG data in patients.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"457-462"},"PeriodicalIF":1.2000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation of polysomnography data and inflammatory markers after sleep surgery.\",\"authors\":\"Öznur Gündüz, Şeyda Akbal Çufalı\",\"doi\":\"10.1080/00016489.2025.2470304\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The occurrence of hypoxia during apneas and hypopneas is associated with the triggering of an inflammatory response.</p><p><strong>Objectives: </strong>This study investigates the alterations in polysomnography (PSG) data, inflammatory markers, and the correlation between these alterations in patients undergoing sleep surgery.</p><p><strong>Methods: </strong>The data of 66 patients who underwent drug-induced sleep endoscopy followed by appropriate sleep surgery, with follow-up PSG performed at 3 to 6 months postoperatively, were retrospectively analyzed. Additionally, correlations with inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), eosinophil-to-lymphocyte ratio (ELR) and systemic immune-inflammation index (SII), were investigated.</p><p><strong>Results: </strong>Comparison of preoperative and postoperative inflammatory markers revealed statistically significant reductions in NLR, PLR, and SII (<i>p</i> < 0.001, <i>p</i> = 0.023, <i>p</i> = 0.026, respectively). Significant positive correlations were identified between AHI and NLR (<i>p</i> = 0.001, <i>r</i> = 0.400), PLR (<i>p</i> = 0.001, <i>r</i> = 0.415) and SII (<i>p</i> = 0.010, <i>r</i> = 0.392). Similarly, a significant positive correlation was observed between supine AHI and NLR (<i>p</i> = 0.035, <i>r</i> = 0.379), PLR (<i>p</i> = 0.008, <i>r</i> = 0.325), and SII (<i>p</i> = 0.030, <i>r</i> = 0.367). The time spent with SaO<sub>2</sub> below 90% was found to be significantly and positively correlated with NLR (<i>p</i> = 0.023, <i>r</i> = 0.279), PLR (<i>p</i> = 0.027, <i>r</i> = 0.272), and SII (<i>p</i> = 0.033, <i>r</i> = 0.256).</p><p><strong>Conclusions and significance: </strong>A correlation was observed between the postoperative decrease in SII, NLR, and PLR values and PSG data in patients.</p>\",\"PeriodicalId\":6880,\"journal\":{\"name\":\"Acta Oto-Laryngologica\",\"volume\":\" \",\"pages\":\"457-462\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Oto-Laryngologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/00016489.2025.2470304\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Oto-Laryngologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00016489.2025.2470304","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/27 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：呼吸暂停和呼吸不足期间缺氧的发生与炎症反应的触发有关。目的：本研究探讨睡眠手术患者多导睡眠图（PSG）数据、炎症标志物的改变，以及这些改变之间的相关性。方法：回顾性分析66例经药物性睡眠内镜检查并行适当睡眠手术的患者的资料，并于术后3 ~ 6月随访PSG。此外，研究了与炎症标志物的相关性，包括中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）、嗜酸粒细胞与淋巴细胞比值（ELR）和全身免疫炎症指数（SII）。结果：术前与术后炎症指标比较，NLR、PLR、SII降低具有统计学意义（p = 0.023, p = 0.026）。AHI与NLR （p = 0.001, r = 0.400）、PLR （p = 0.001, r = 0.415）、SII （p = 0.010, r = 0.392）呈显著正相关。同样，仰卧位AHI与NLR （p = 0.035, r = 0.379）、PLR （p = 0.008, r = 0.325）、SII （p = 0.030, r = 0.367）呈正相关。SaO2低于90%的时间与NLR （p = 0.023, r = 0.279）、PLR （p = 0.027, r = 0.272）、SII （p = 0.033, r = 0.256）呈显著正相关。结论及意义：患者术后SII、NLR、PLR值下降与PSG数据存在相关性。
Correlation of polysomnography data and inflammatory markers after sleep surgery.
Background: The occurrence of hypoxia during apneas and hypopneas is associated with the triggering of an inflammatory response.
Objectives: This study investigates the alterations in polysomnography (PSG) data, inflammatory markers, and the correlation between these alterations in patients undergoing sleep surgery.
Methods: The data of 66 patients who underwent drug-induced sleep endoscopy followed by appropriate sleep surgery, with follow-up PSG performed at 3 to 6 months postoperatively, were retrospectively analyzed. Additionally, correlations with inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), eosinophil-to-lymphocyte ratio (ELR) and systemic immune-inflammation index (SII), were investigated.
Results: Comparison of preoperative and postoperative inflammatory markers revealed statistically significant reductions in NLR, PLR, and SII (p < 0.001, p = 0.023, p = 0.026, respectively). Significant positive correlations were identified between AHI and NLR (p = 0.001, r = 0.400), PLR (p = 0.001, r = 0.415) and SII (p = 0.010, r = 0.392). Similarly, a significant positive correlation was observed between supine AHI and NLR (p = 0.035, r = 0.379), PLR (p = 0.008, r = 0.325), and SII (p = 0.030, r = 0.367). The time spent with SaO2 below 90% was found to be significantly and positively correlated with NLR (p = 0.023, r = 0.279), PLR (p = 0.027, r = 0.272), and SII (p = 0.033, r = 0.256).
Conclusions and significance: A correlation was observed between the postoperative decrease in SII, NLR, and PLR values and PSG data in patients.
期刊介绍：
Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.
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