Diagnostic, survival, and tumor control outcomes of parapharyngeal space liposarcoma: a systematic review.

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI:10.1080/00016489.2025.2462688

Srivatsa Surya Vasudevan, Estephania Candelo, Tiba Yamin Kandrikar, Jeffrey R Janus

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引用次数: 0

Abstract

Background: Parapharyngeal space liposarcomas (PPS-LS) are rare tumors often associated with a moderate-to-poor prognosis.

Objectives: This study aims to assess tumor control and survival outcomes across the various subtypes of PPS-LS.

Material and methods: We conducted a systematic review of cases using PubMed, OVID, Scopus, Web of Science, ScienceDirect, and EBSCO from inception to October 2024. Given the data on individual patient follow-up, Kaplan-Meier survival analysis was utilized to calculate disease-free survival (DFS) and disease-specific survival (DSS).

Results: Out of 303 articles, 10 studies with 11 patients (72.7% male) met the inclusion criteria, with a mean age of 51.3 years (range: 12-77.5). Preoperative fine needle aspiration cytology was conducted in 45.4%, with 80% yielding inconclusive results. The 2-year and 5-year DFS rates for PPS-LS were 64% and 50%, respectively, while the 2-year DSS rate was 84%. Tumor recurrence occurred in 36.3% of patients, with an average of 2.5 recurrences per patient, specifically the myxoid subtype of PPS-LS.

Conclusion: This systematic review highlights the varied prognostic outcomes of PPS-LS and its subtypes, emphasizing the need for vigilant surveillance to improve DFS and reduce recurrence rates.

Significance: This provides surgeons with critical insights into probable prognostic outcomes when dealing with specific subtypes of PPS-LS.

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咽旁间隙脂肪肉瘤的诊断、生存和肿瘤控制结果：一项系统综述。

背景：咽旁间隙脂肪肉瘤（PPS-LS）是一种罕见的肿瘤，通常预后较差。目的：本研究旨在评估不同亚型PPS-LS的肿瘤控制和生存结果。材料和方法：我们通过PubMed、OVID、Scopus、Web of Science、ScienceDirect和EBSCO对从成立到2024年10月的病例进行了系统综述。根据患者个体随访数据，采用Kaplan-Meier生存分析计算无病生存期（DFS）和疾病特异性生存期（DSS）。结果：303篇文献中，10项研究11例患者（72.7%为男性）符合纳入标准，平均年龄51.3岁（范围：12-77.5岁）。术前细针穿刺细胞学检查占45.4%，80%结果不确定。ps - ls的2年和5年DFS率分别为64%和50%，2年DSS率为84%。36.3%的患者出现肿瘤复发，平均每例患者2.5次复发，特别是黏液样亚型PPS-LS。结论：本系统综述强调了PPS-LS及其亚型的不同预后结果，强调需要警惕监测以改善DFS和降低复发率。意义：这为外科医生在处理PPS-LS的特定亚型时提供了可能的预后结果的关键见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Oto-Laryngologica 医学-耳鼻喉科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.