Li Jin, Xueying Pan, Tuanfang Yin, Jihao Ren, Wei Liu
{"title":"Efficacy of endoscopic porcine small intestinal submucosa graft myringoplasty: a retrospective comparative study.","authors":"Li Jin, Xueying Pan, Tuanfang Yin, Jihao Ren, Wei Liu","doi":"10.1080/00016489.2023.2182451","DOIUrl":"https://doi.org/10.1080/00016489.2023.2182451","url":null,"abstract":"<p><strong>Background: </strong>The surgical outcomes following tympanic membrane (TM) repair are affected by many factors.</p><p><strong>Objectives: </strong>To evaluate the efficacy of endoscopic porcine small intestine submucosa graft (PSISG) myringoplasty by comparing with endoscopic myringoplasty with temporal fascia (TF) and perichondrium (PC).</p><p><strong>Methods: </strong>We conducted a retrospective comparative study that a total of 98 patients with TM perforations were included. The patients underwent endoscopic myringoplasty using PSISG, TF or PC as the graft. The closure rate, hearing outcomes, operative time and complications in three groups were compared.</p><p><strong>Results: </strong>At 3 months postoperatively, the closure rate were 85.2% (23/27), 92.1% (35/38) and 87.9% (29/33) in the PSISG, TF and PC groups respectively (<i>p</i> = .667); Hearing improved after surgery in three groups (<i>p</i> < .001), and showed no significant difference among the three groups. The mean operative time of the PSISG group was shorter than autologous TF (<i>p</i> < .001) and PC groups (<i>p</i> < .001) in this study; No operative or postoperative complications were found among the three groups.</p><p><strong>Conclusion: </strong>Compare to autologous temporal fascia or perichondrium, the PSISG appears to be an effective and safe material for TM perforations closure. Endoscopic PSISG myringoplasty may be an alternative technique for repairing TM perforations, especially for revision cases.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 4","pages":"274-279"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9397882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ricardo Bartel, Francesc Cruellas, Miguel Garcia-Wagner, Miriam Hamdan, Gabriel Huguet, Marta Mesalles, Anna Penella
{"title":"Transcanal endoscopic type 3 tympanoplasty with mastoid preservation for advanced active chronic mucosal otitis media.","authors":"Ricardo Bartel, Francesc Cruellas, Miguel Garcia-Wagner, Miriam Hamdan, Gabriel Huguet, Marta Mesalles, Anna Penella","doi":"10.1080/00016489.2023.2184863","DOIUrl":"https://doi.org/10.1080/00016489.2023.2184863","url":null,"abstract":"<p><strong>Background: </strong>Chronic mucosal otitis media is a very common ear disease for which patients attend otolaryngology clinics. Most of these patients present with actively discharging ears.</p><p><strong>Aims/objectives: </strong>This study aims to observe the middle ear space pathology and obtain surgical outcomes as a treatment for patients with advanced chronic mucosal otitis media with a transcanal endoscopic ear surgery approach.</p><p><strong>Materials and methods: </strong>A prospective study was designed, and patients suffering from chronic mucosal otitis media in the active suppurative phase with an air-bone gap larger than 20 dB were included.</p><p><strong>Results: </strong>70 operated ears were included. Underlying macroscopic pathology within the middle ear space was observed: Middle ear granulomas at 58.6%; Tympanosclerosis 41.4%. Blockage of the tympanic isthmus was evaluated, obtaining a blockage rate of 81.4%. At 12 months of evaluation after surgery, a postoperative ABG < 20 dB was achieved in 85.7% of the operated ears. An overall closed tympanic membrane was obtained in 88.6% of the patients.</p><p><strong>Conclusion: </strong>This prospective cohort study shows the short-term efficacy of transcanal endoscopic type 3 tympanoplasty with mastoid preservation for managing advanced chronic mucosal otitis media. Clinical trials are required to give more evidence to the present matter.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 4","pages":"280-283"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9397883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Oto-LaryngologicaPub Date : 2023-04-01Epub Date: 2023-04-02DOI: 10.1080/00016489.2023.2191646
Freja Sterner, Anders Högmo, Krister Tano
{"title":"Carcinomas of the minor salivary glands of the oral cavity. A population-based study from the Swedish Head and Neck Cancer Register for 2008-2018.","authors":"Freja Sterner, Anders Högmo, Krister Tano","doi":"10.1080/00016489.2023.2191646","DOIUrl":"10.1080/00016489.2023.2191646","url":null,"abstract":"<p><strong>Background and objectives: </strong>Carcinomas of the minor salivary glands are rare with a heterogeneous pathology. This study explored the demographics, histology, treatment and survival in the Swedish population over 11 years.</p><p><strong>Material and methods: </strong>Cases of salivary gland carcinomas in the oral cavity were extracted from the 'Swedish Head and Neck Cancer Register' (2008-2018). Statistical analyses with cross tabulation, age grouping, chi-square, the Kaplan-Meier method and log-rank tests were performed.</p><p><strong>Results: </strong>Three hundred thirty cases were included (62% female; mean age 60 years; 83% were WHO Performance Status 0). The carcinomas were mostly stage I (57%), and the most common site was the palate with 165 tumours (50%). The most common histology was mucoepidermoid carcinoma (30%), followed by polymorphous low-grade adenocarcinoma (25%) and adenoid cystic carcinoma (24%). The distribution of histology differed between age groups. The five-year predicted overall survival rate was 83%. Most patients (89%) were treated with primary surgery.</p><p><strong>Conclusion and significance: </strong>The demographics, histology, and survival of minor salivary gland carcinomas in the oral cavity in the Swedish population correspond well with previously published material. The demographics and histology differ from carcinomas of the major salivary glands in the same population.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 4","pages":"340-345"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9454737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jian Zhou, Xiaoke Zhu, Yue Yang, Liang Zhou, Hongli Gong, Chengzhi Xu, Lei Tao
{"title":"Predictive value of pathological carcinoma size in patients with T2 glottic laryngeal squamous cell carcinoma.","authors":"Jian Zhou, Xiaoke Zhu, Yue Yang, Liang Zhou, Hongli Gong, Chengzhi Xu, Lei Tao","doi":"10.1080/00016489.2023.2188083","DOIUrl":"https://doi.org/10.1080/00016489.2023.2188083","url":null,"abstract":"<p><strong>Background: </strong>T2N0M0 glottic laryngeal squamous cell carcinoma (LSCC) is a common type of laryngeal cancer.</p><p><strong>Objectives: </strong>The objective of this research was to assess the predictive value of tumor size for the rates of overall survival (OS) and disease-free survival (DFS) as determined by postoperative pathological examination in patients with T2 LSCC.</p><p><strong>Methods: </strong>A retrospective study was conducted on 535 successive patients with T2 glottic LSCC who underwent operation from 2005 to 2010. The effect of tumor size on OS and DFS results was evaluated by the affected area.</p><p><strong>Results: </strong>Of the cohort, 528 (98.7%) were male, and 7 (1.3%) were female, with an average age of 60.1 ± 9.4 years. The 10-year DFS and OS rates were 72.1% and 76.3%, respectively. The tumor diameter and area cut-off values that best discriminated OS and DFS rates were 1.35 cm and 1 cm<sup>2</sup>, respectively. Patients with glottis carcinoma with a longer tumor diameter and larger tumor area had inferior OS and DFS rates. Tumor diameter and tumor area were independent predictive factors for the rates of OS and DFS in patients with T2 glottic LSCC.</p><p><strong>Conclusion and significance: </strong>This research showed that patients with T2 glottic LSCC with a carcinoma diameter >1.35 cm or a tumor area >1 cm<sup>2</sup> have worse survival outcomes. These factors independently predict survival outcomes in patients.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 4","pages":"317-321"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9397510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jin Wang, Meng Zhang, Wenqi Yi, Liang Li, Liangyu Li, Chuan Pang, Lei Chen
{"title":"Locally advanced sinonasal adenoid cystic carcinomas: endoscopic endonasal surgery-centered comprehensive treatment provides benefits.","authors":"Jin Wang, Meng Zhang, Wenqi Yi, Liang Li, Liangyu Li, Chuan Pang, Lei Chen","doi":"10.1080/00016489.2023.2199035","DOIUrl":"https://doi.org/10.1080/00016489.2023.2199035","url":null,"abstract":"<p><strong>Background: </strong>Sinonasal adenoid cystic carcinomas (SNACCs) are aggressive tumors that show massive expansion and are challenging to treat when locally advanced.</p><p><strong>Aims: </strong>To report our experiences with endoscopic endonasal surgery (EES) - centered comprehensive treatment and discuss the associated outcomes of these patients.</p><p><strong>Material and methods: </strong>A retrospective review of primary locally advanced SNACCs patients was conducted in a single center. EES combined with postoperative radiotherapy (PORT) was used as a comprehensive surgery-centered approach to treat these patients.</p><p><strong>Results: </strong>The study included 44 patients with Stage III/IV tumors. The median follow-up duration was 43 months (4-161 months). Forty-two patients underwent PORT. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 61.2% and 46%, respectively. Local recurrence occurred in 7 patients, and 19 patients had distant metastasis. No significant relationship was found between OS and postoperative local recurrence. The OS of patients with Stage IV or exhibiting distant postoperative metastases was shorter than that of other patients.</p><p><strong>Conclusions and significance: </strong>Locally advanced SNACCs are not a contraindication for EES. EES-centered comprehensive treatment can ensure satisfactory survival rates and reasonable local control. Function-preserving surgery using EES and PORT may represent an alternative strategy when vital structures are involved.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 4","pages":"301-308"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9404036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phillip G Bragg, Benjamin M Norton, Michelle R Petrak, Allyson D Weiss, Lindsay M Kandl, Megan L Corrigan, Cammy L Bahner, Akihiro J Matsuoka
{"title":"Application of supervised machine learning algorithms for the evaluation of utricular function on patients with Meniere's disease: utilizing subjective visual vertical and ocular-vestibular-evoked myogenic potentials.","authors":"Phillip G Bragg, Benjamin M Norton, Michelle R Petrak, Allyson D Weiss, Lindsay M Kandl, Megan L Corrigan, Cammy L Bahner, Akihiro J Matsuoka","doi":"10.1080/00016489.2023.2190163","DOIUrl":"https://doi.org/10.1080/00016489.2023.2190163","url":null,"abstract":"<p><strong>Background: </strong>Research on the otolith organs remains inconclusive.</p><p><strong>Objectives: </strong>This study seeks to further elucidate utricular function in patients with Meniere's disease (MD) in three ways: (1) We aimed to disambiguate the role of the Subjective Visual Vertical (SVV) and Ocular Vestibular Evoked Myogenic Potential (o-VEMP) tests regarding which utricular subsystem each is measuring. (2) We sought to characterize the acute and chronic state of MD by identifying differences in the relationship of SVV and o-VEMP results across patients with acute and chronic MD. (3) We attempted to find a machine-learning algorithm that could predict acute versus chronic MD using SVV and o-VEMP.</p><p><strong>Methods: </strong>A prospective study with ninety subjects.</p><p><strong>Results: </strong>(1) SVV and o-VEMP tests were found to have a moderate linear relationship in patients with acute MD, suggesting each test measures a different utricular subsystem. (2) Regression analyses statistically differed across the two patient populations, suggesting that SVV results were normalized in chronic MD patients. (3) Logistic regression and Naïve Bayes algorithms were found to predict acute and chronic MD accurately.</p><p><strong>Significance: </strong>A better understanding of what diagnostic tests measure will lead to a better classification system for MD and more targeted treatment options in the future.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 4","pages":"262-273"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9751714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lars Juul Hansen, Sune Land Bloch, Mads Sølvsten Sørensen
{"title":"Cellular voids in the pathogenesis of otosclerosis.","authors":"Lars Juul Hansen, Sune Land Bloch, Mads Sølvsten Sørensen","doi":"10.1080/00016489.2023.2164904","DOIUrl":"https://doi.org/10.1080/00016489.2023.2164904","url":null,"abstract":"<p><strong>Background: </strong>Otosclerosis is a common ear disease that causes fixation of the stapes and conductive hearing impairment. However, the pathogenesis of otosclerosis is still unknown. Otosclerosis could be associated with the unique bony environment found in the otic capsule. Normal bone remodelling is almost completely absent around the inner ear after birth allowing degenerative changes and dead osteocytes to accumulate. High levels of inner ear anti resorptive osteoprotegerin (OPG) is most likely responsible for this capsular configuration. Studies have demonstrated how osteocyte lifespan variation creates occasional clusters of dead osteocytes, so-called cellular voids, at otosclerotic predilection sites in the human otic capsule. These cellular voids have been suggested as possible starting points of otosclerosis.</p><p><strong>Aim: </strong>To describe the cellular viability in otosclerotic lesions and compare it to that of cellular voids.</p><p><strong>Materials and methods: </strong>The study was based on unbiased stereological quantifications in undecalcified human temporal bones with otosclerosis.</p><p><strong>Results: </strong>Osteocyte viability was found to vary within the otosclerotic lesions. Furthermore, the results presented here illustrate that inactive otosclerotic lesions consist of mainly dead interstitial bone, much like cellular voids.</p><p><strong>Conclusions and significance: </strong>Focal degeneration in the otic capsule may play an important role in the pathogenesis of otosclerosis.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 3","pages":"250-253"},"PeriodicalIF":1.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9237579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramzi R Maalouf, Morgane Marc, Payal Mukherjee, Vincent Van Rompaey, Michael Eliezer, Charlotte Hautefort, Benjamin Verillaud, Philippe Herman, Romain Kania
{"title":"Otosclerosis: audiometric results and quality of life after stapedectomy with interposition or CO<sub>2</sub> laser-calibrated stapedotomy without interposition.","authors":"Ramzi R Maalouf, Morgane Marc, Payal Mukherjee, Vincent Van Rompaey, Michael Eliezer, Charlotte Hautefort, Benjamin Verillaud, Philippe Herman, Romain Kania","doi":"10.1080/00016489.2023.2186482","DOIUrl":"https://doi.org/10.1080/00016489.2023.2186482","url":null,"abstract":"<p><strong>Background: </strong>The surgical treatment of otosclerosis consists of the replacement of the stapes using a piston.</p><p><strong>Aims/objectives: </strong>The objective of this study is to assess the audiometric results and quality of life (QOL) of patients who underwent surgery for otosclerosis by stapedectomy with fascia interposition (STIP) or by stapedotomy using CO<sub>2</sub> laser (SLaser) without fascia interposition.</p><p><strong>Material and methods: </strong>Ninety-one patients operated on for otosclerosis by STIP (40 patients) and by SLaser (51 patients) were included. Audiometric results were graphically displayed using the Amsterdam Hearing Evaluation Plot and were compared to the Common Otology Database (COD) comprising 660 patients. The patients' QOL was assessed with an otological validated survey. The significance level was <i>p</i> < .05.</p><p><strong>Results: </strong>There was no significant difference in hearing improvement between SLaser and STIP-operated patients. There was no significant difference between our results and that of COD. QOL was significantly improved (+3.5/10) postoperatively for both STIP and SLaser in both social and professional fields.</p><p><strong>Conclusions and significance: </strong>By comparing QOL and hearing gain of STIP and SLaser, our results suggest that both surgical techniques are a safe and successful treatment for otosclerotic stapes fixation. Further studies aiming at comparing larger series may confirm and refine these results.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 3","pages":"231-236"},"PeriodicalIF":1.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9293979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Oto-LaryngologicaPub Date : 2023-03-01Epub Date: 2023-03-10DOI: 10.1080/00016489.2023.2182911
Kaitlyn A Brooks, Nathaniel S Neptune, Douglas E Mattox
{"title":"Otolaryngologic manifestations of Mpox: the Atlanta outbreak.","authors":"Kaitlyn A Brooks, Nathaniel S Neptune, Douglas E Mattox","doi":"10.1080/00016489.2023.2182911","DOIUrl":"10.1080/00016489.2023.2182911","url":null,"abstract":"<p><strong>Background: </strong>In 2022, Mpox (MPX) has become clinically relevant as otolaryngologists are evaluating this exotic disease process due to its many otolaryngologic manifestations.</p><p><strong>Aims/objective: </strong>To characterize our cohort of otolaryngology-relevant MPX confirmed cases.</p><p><strong>Materials and methods: </strong>A descriptive case series was performed <i>via</i> retrospective review. Adult patients who underwent inpatient or emergency department otolaryngology consultation at an Emory University-affiliated tertiary care level hospital for MPX were included.</p><p><strong>Results: </strong>Seven patients (age 18-58 years; median 32 years) were identified. All patients were male. Six patients (86%) were black and six patients (86%) were HIV positive with varied immunocompetence. Otolaryngology was consulted for lymphadenopathy (<i>n</i> = 2), pharyngeal involvement (<i>n</i> = 1), and airway evaluation (<i>n</i> = 4). All 6 patients with active MPX developed the classic rash, which developed after oropharyngeal symptoms in 3 patients. Three patients had laryngeal involvement.</p><p><strong>Conclusion: </strong>MPX manifests with symptoms requiring otolaryngology expertise, especially when the airway is involved. Infectious disease consultation is key. Mpox can be identified with a specific constellation of demographic identifiers and physical exam findings, which is key to determining appropriate treatment and protection for the consulting otolaryngologist.</p><p><strong>Significance: </strong>This is the first otolaryngologic study of Mpox and first description of Mpox laryngeal involvement.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 3","pages":"237-241"},"PeriodicalIF":1.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9608015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Title page for CORLAS special issue.","authors":"","doi":"10.1080/00016489.2023.2187453","DOIUrl":"https://doi.org/10.1080/00016489.2023.2187453","url":null,"abstract":"","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"143 3","pages":"205"},"PeriodicalIF":1.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}