Acta Oto-Laryngologica最新文献_第10页

Association between sleep-related breathing Disorder symptoms and parasomnias in children with adenoid hypertrophy scheduled for adenoidectomy. 拟行腺样体切除术的腺样体肥大患儿睡眠相关呼吸障碍症状与睡眠异常的关系

IF 1.3 4区医学

Acta Oto-Laryngologica Pub Date : 2026-07-14 DOI: 10.1080/00016489.2026.2700009

Pınar Tekin, Zeynep İskender Emekli, Sevilay Hançer Tecimer

{"title":"Association between sleep-related breathing Disorder symptoms and parasomnias in children with adenoid hypertrophy scheduled for adenoidectomy.","authors":"Pınar Tekin, Zeynep İskender Emekli, Sevilay Hançer Tecimer","doi":"10.1080/00016489.2026.2700009","DOIUrl":"10.1080/00016489.2026.2700009","url":null,"abstract":"Background: Sleep-related breathing disorders (SRBD) in children are frequently associated with adenoid hypertrophy. A correlation has been identified between SRBD and numerous sleep-related disturbances, such as parasomnias. However, the relationship between SRBD symptoms and parasomnias in children undergoing adenoidectomy remains poorly understood.Aims: This study was designed to investigate the relationship between SRBD symptoms and parasomnias in children undergoing adenoidectomy.Materials and methods: In this study of 54 pediatric patients with adenoid hypertrophy, sleep symptoms and disturbances were measured via the Pediatric Sleep Questionnaire -Related Breathing Disorder (PSQ-SRBD) and Sleep Disturbance Scale for Children (SDSC) scales. Parasomnias (e.g. enuresis, sleepwalking) were documented through parental reports, followed by correlation analyses and group comparisons between symptomatic and asymptomatic children.Results: Analysis revealed a significant positive relationship between PSQ-SRBD and SDSC scores (r = 0.577, p < 0.001). Children with parasomnia symptoms demonstrated higher PSQ-SRBD and SDSC scores compared to those without parasomnias. Parasomnias were frequently reported among children with prominent SRBD symptoms.Conclusions and significance: Higher SRBD symptom burden is associated with increased prevalence of parasomnias. Overall, these findings underscore the need for comprehensive evaluation of sleep disturbances in pediatric patients undergoing adenoidectomy.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and efficacy of canalith-repositioning maneuvers for benign paroxysmal positional vertigo in very elderly patients. 导管复位术治疗高龄良性阵发性体位性眩晕的特点及疗效。

IF 1.3 4区医学

Acta Oto-Laryngologica Pub Date : 2026-07-14 DOI: 10.1080/00016489.2026.2700011

Yunlong Bai, Liyan Chen, Hong Zhao, Denghua Yang, Jie Li, Boxuan Wang

{"title":"Characteristics and efficacy of canalith-repositioning maneuvers for benign paroxysmal positional vertigo in very elderly patients.","authors":"Yunlong Bai, Liyan Chen, Hong Zhao, Denghua Yang, Jie Li, Boxuan Wang","doi":"10.1080/00016489.2026.2700011","DOIUrl":"https://doi.org/10.1080/00016489.2026.2700011","url":null,"abstract":"Background: Benign paroxysmal positional vertigo (BPPV) is highly prevalent in very elderly patients (aged ≥80 years), who present complex comorbidities, atypical manifestations, poor mobility, and high fall risk, leading to diagnostic and therapeutic challenges. Evidence on this population is scarce.Aims/objectives: To clarify clinical features, treatment efficacy, recurrence patterns, and risk factors in very elderly BPPV patients.Material and methods: Retrospective analysis of 128 very elderly patients with BPPV.Results: Treatment was tolerated by 93.75% (120/128); cure and improvement rates were 93.3% (112/120) and 97.5% (117/120), respectively. The crude recurrence rate was 23.2% (26/112); 76.9% of recurrences were ipsilateral, with 69.2% involving the same canal. Kaplan-Meier estimates, accounting for censored observations, yielded cumulative recurrence rates of 6.3% (95% CI: 1.7%-10.6%) at 1 month, 14.3% (95% CI: 7.6%-20.5%) at 3 months, 18.2% (95% CI: 10.7%-25.1%) at 6 months, and 24.4% (95% CI: 15.3%-32.7%) at 12 months. Multivariable Cox regression identified prior BPPV (HR = 2.416, p = 0.039) and sleep disturbance (HR = 2.448, p = 0.028) as independent predictors.Conclusions and significance: Very elderly patients (aged ≥80 years) with BPPV show high treatment tolerance and favorable outcomes. Prior BPPV and sleep disturbance are independent predictors of recurrence. Individualized repositioning strategies are recommended.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148443711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lesser palatine nerve block in multilevel sleep surgery for obstructive sleep apnea: a feasibility and pilot efficacy study. 小腭神经阻滞在多阶段睡眠手术治疗阻塞性睡眠呼吸暂停：可行性和初步疗效研究。

IF 1.3 4区医学

Acta Oto-Laryngologica Pub Date : 2026-07-10 DOI: 10.1080/00016489.2026.2696429

Hui Yan Ong, Liang Chye Goh, Ahmad Syahir Md Ismail, Siti Nadzrah Yunus

{"title":"Lesser palatine nerve block in multilevel sleep surgery for obstructive sleep apnea: a feasibility and pilot efficacy study.","authors":"Hui Yan Ong, Liang Chye Goh, Ahmad Syahir Md Ismail, Siti Nadzrah Yunus","doi":"10.1080/00016489.2026.2696429","DOIUrl":"https://doi.org/10.1080/00016489.2026.2696429","url":null,"abstract":"Background: To evaluate intraoperative lesser palatine nerve block (LPNB) for postoperative pain control in multilevel sleep surgery for obstructive sleep apnea (OSA).Aims and objectives: To evaluate the feasibility of using an intraoperative lesser palatine nerve block (LPNB) to manage postoperative pain in adult patients undergoing multilevel sleep surgery for obstructive sleep apnea.Materials and methods: Retrospective cohort of 62 adults receiving standardised multimodal analgesia with (n = 35) or without (n = 27) bilateral LPNB (0.5% bupivacaine with epinephrine). Primary outcome: visual analog scale (VAS) pain scores at 6 h and Day 1.Results: LPNB was feasible and safe with no adverse events across all 35 administrations. A clinically meaningful pain reduction trend at 6 h (3.14 ± 1.33 vs 3.85 ± 1.63; 18% reduction; p = 0.076) and a statistically significant reduction at Day 1 (3.00 ± 1.50 vs 3.89 ± 1.58; 23% reduction; p = 0.027). In the pre specified high risk subgroup of severe OSA patients, exploratory analysis showed significantly lower pain at 6 h (3.00 ± 1.38 vs 4.21 ± 1.42; p = 0.023). On multivariable adjustment, LPNB was associated with reduced odds of moderate to severe pain (adjusted OR 0.38; 95% CI 0.13-1.13; p = 0.082).Conclusions and significance: LPNB is feasible, safe, and associated with a clinically meaningful analgesic signal.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vasopressin type-2 receptor mRNA expressions in endolymphatic sac and temporal bone cT findings in Meniere's disease. 抗利尿激素2型受体mRNA在梅尼埃病内淋巴囊和颞骨的表达

IF 1.3 4区医学

Acta Oto-Laryngologica Pub Date : 2026-07-03 DOI: 10.1080/00016489.2026.2695180

Hajime Kageyama, Tadashi Kitahara, Masaharu Sakagami, Tadao Okayasu, Chihiro Morimoto, Takefumi Kamakura

{"title":"Vasopressin type-2 receptor mRNA expressions in endolymphatic sac and temporal bone cT findings in Meniere's disease.","authors":"Hajime Kageyama, Tadashi Kitahara, Masaharu Sakagami, Tadao Okayasu, Chihiro Morimoto, Takefumi Kamakura","doi":"10.1080/00016489.2026.2695180","DOIUrl":"10.1080/00016489.2026.2695180","url":null,"abstract":"Background: The temporal bone pathology of Meniere's disease was proven to be endolymphatic hydrops. However, the mechanisms surrounding hydrops development and symptom onset in Meniere's disease remain unclear.Aims/objectives: The purpose of this study was to investigate relationships between endolymphatic sac hypoplasia in Meniere's disease and stress hormone vasopressin type-2 receptor (V2R) mRNA expression in endolymphatic sac.Material and methods: First, we examined temporal bone CT (TBCT) in patients with intractable Meniere's disease before surgery to evaluate endolymphatic sac hypoplasia. Then, we obtained endolymphatic sac tissues during surgery to examine V2R mRNA expression using real-time PCR.Results: All the intractable Meniere's cases were divided into poorly pneumatized retrolabyrinthine air cells PPR group (n = 9) and non PPR group (n = 3) through the TBCT evaluation. V2R mRNA expression were significantly higher in PPR group (n = 9; 31.78 ± 7.54 fold) than non PPR one (n = 3; 4.22 ± 2.61 fold) through the real-time PCR (Welch's t-test: t = 3.45; p = 0.0072).Conclusions and significance: Several evidences have suggested that functional dysregulation of inner ear fluid homeostasis is associated with endolymphatic hydrops and Meniere's disease. Taken together with the present study, it is suggested that coexistence of endolymphatic sac hypoplasia and V2R mRNA overexpression might determine the affected side of endolymphatic hydrops.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vestibular function prior to cochlear implantation in patients with non-syndromic hearing loss caused by CDH23 mutations: a retrospective case series. 由CDH23突变引起的非综合征性听力损失患者在人工耳蜗植入前的前庭功能：回顾性病例系列

IF 1.3 4区医学

Acta Oto-Laryngologica Pub Date : 2026-07-01 Epub Date: 2026-03-13 DOI: 10.1080/00016489.2026.2637697

Kento Koda, Aki Sakata, Hajime Koyama, Kentaro Ichijo, Mineko Oka, Teru Kamogashira, Makoto Kinoshita, Anjin Mori, Akinori Kashio, Kenji Kondo, Chisato Fujimoto

{"title":"Vestibular function prior to cochlear implantation in patients with non-syndromic hearing loss caused by CDH23 mutations: a retrospective case series.","authors":"Kento Koda, Aki Sakata, Hajime Koyama, Kentaro Ichijo, Mineko Oka, Teru Kamogashira, Makoto Kinoshita, Anjin Mori, Akinori Kashio, Kenji Kondo, Chisato Fujimoto","doi":"10.1080/00016489.2026.2637697","DOIUrl":"10.1080/00016489.2026.2637697","url":null,"abstract":"Background: Vestibular involvement in CDH23-related nonsyndromic hearing loss remains incompletely understood, particularly prior to cochlear implantation.Aims/objectives: To evaluate vestibular function prior to cochlear implantation in patients with severe to profound non-syndromic hearing loss caused by CDH23 mutations.Material and methods: We retrospectively evaluated vestibular function in seven patients with severe to profound non-syndromic hearing loss caused by CDH23 mutations who were scheduled for cochlear implantation. Vestibular assessment included caloric testing, ACS-cVEMP, BCV-oVEMP, and damped rotation testing, depending on age.Results: Six patients had homozygous missense mutations, and one had compound heterozygous mutations in CDH23. Caloric testing revealed unilateral reduced responses in two patients (28.6%). Damped rotation testing, performed in four pediatric patients, showed a unilateral reduced response in one patient (25%). ACS-cVEMP demonstrated a unilateral reduced response in one patient (14.3%) and an absent response in another (14.3%). BCV-oVEMP, conducted in three patients, revealed a unilateral absent response in one patient (33.3%). Overall, unilateral vestibular dysfunction was identified in four of seven patients (57.1%).Conclusions and significance: More than half of patients with CDH23-related non-syndromic deafness exhibited unilateral vestibular dysfunction prior to cochlear implantation, suggesting that preoperative vestibular assessment may be clinically relevant in this population.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"851-857"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protective efficacy of rosmarinic acid in radiotherapy-induced ototoxicity. 迷迭香酸对放射线致耳毒性的保护作用。

IF 1.3 4区医学

Acta Oto-Laryngologica Pub Date : 2026-07-01 Epub Date: 2026-03-26 DOI: 10.1080/00016489.2026.2641822

Serkan Altıparmak, İbrahim Özcan, Altan Kaya, Aynur Aytekin, Hatice Karaman

{"title":"The protective efficacy of rosmarinic acid in radiotherapy-induced ototoxicity.","authors":"Serkan Altıparmak, İbrahim Özcan, Altan Kaya, Aynur Aytekin, Hatice Karaman","doi":"10.1080/00016489.2026.2641822","DOIUrl":"10.1080/00016489.2026.2641822","url":null,"abstract":"Background: Radiotherapy-induced ototoxicity remains a significant clinical problem, and potential protective agents such as rosmarinic acid have gained increasing research interest.Objectives: This study investigated the effectiveness of systemic and local rosmarinic acid administration in radiotherapy-induced ototoxicity using the auditory brainstem response (ABR), distortion product otoacoustic emission (DPOAE) test, and histopathological methods.Material and methods: Sixty rats were included in the study. Seven groups were created, including control, radiotherapy-only, and combinations of radiotherapy with intratympanic or intraperitoneal rosmarinic acid, as well as a radiotherapy plus intratympanic saline group. ABR and DPOAE measurements were performed with all animals initially and at the end of the third week. The temporal bones of the decapitated rats were also fixed in formalin for histopathological measurements.Results: ABR thresholds increased significantly in the radiotherapy-only group (from 22.8 ± 3.1 to 45.4 ± 3.6 dB, p = 0.004) and the radiotherapy plus intratympanic saline group (from 24.6 ± 3.1 to 47.1 ± 3.6 dB, p = 0.005), while remaining stable in the other groups (p > 0.05). Correspondingly, DPOAE values decreased and histopathological damage scores were markedly higher in these two groups.Conclusions and significance: Rosmarinic acid protects against radiotherapy-induced ototoxicity when applied both systemically and locally, as confirmed by histopathological examination and objective audiological methods.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"908-915"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopy-guided bilateral olfactory mucosal biopsy: a safe and reproducible outpatient technique. 内镜引导下双侧嗅粘膜活检：一种安全、可重复的门诊技术。

IF 1.3 4区医学

Acta Oto-Laryngologica Pub Date : 2026-07-01 Epub Date: 2026-03-31 DOI: 10.1080/00016489.2026.2640210

Ala Muala, Robert Buckland, Katarina Olofsson, Elina Penttilä, Katja M Kanninen, Maria Friberg

{"title":"Endoscopy-guided bilateral olfactory mucosal biopsy: a safe and reproducible outpatient technique.","authors":"Ala Muala, Robert Buckland, Katarina Olofsson, Elina Penttilä, Katja M Kanninen, Maria Friberg","doi":"10.1080/00016489.2026.2640210","DOIUrl":"10.1080/00016489.2026.2640210","url":null,"abstract":"Background: Reliable access to the olfactory epithelium is important for clinical and translational research; however, data on bilateral biopsy performed in an outpatient setting are limited.Objectives: To evaluate the feasibility and procedural outcomes of endoscopy-guided bilateral olfactory epithelium biopsy performed under local anaesthesia in an outpatient setting following controlled exposure sessions.Methods: Healthy adults participated in a randomized, double-blind, crossover exposure study. Endoscopy-guided biopsies were obtained in an outpatient setting. Primary outcomes included bilateral biopsy success, tolerability, adverse events, and nucleic acid yield.Results: Twenty-nine subjects were enrolled; 26 completed the study. Bilateral biopsies were obtained more frequently after implementation of pre-endoscopic screening than without screening (75.0% vs 30.0%; odds ratio 7.0, 95% CI 1.20-40.83). No serious procedural complications were observed. One self-limiting episode of delayed epistaxis. No participant reported postoperative olfactory dysfunction. All samples yielded RNA and DNA of sufficient quantity and purity for downstream analyses.Conclusion: Endoscopy-guided bilateral olfactory epithelium biopsy appears feasible in a carefully screened outpatient cohort. Pre-endoscopic anatomical assessment was associated with improved procedural success. Although objective olfactory testing was not performed, and subtle functional changes cannot be excluded, this technique provides a reproducible methodological framework for future studies involving the olfactory cleft.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"871-878"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical honey as adjunctive therapy to standard dressing in deep neck abscess: a single-blind randomized controlled trial. 局部蜂蜜作为标准敷料治疗深颈脓肿的辅助疗法：一项单盲随机对照试验。

IF 1.3 4区医学

Acta Oto-Laryngologica Pub Date : 2026-07-01 Epub Date: 2026-03-17 DOI: 10.1080/00016489.2026.2640609

Dian Paramita Wulandari, Yanri Wijayanti Subronto, Agus Surono

{"title":"Topical honey as adjunctive therapy to standard dressing in deep neck abscess: a single-blind randomized controlled trial.","authors":"Dian Paramita Wulandari, Yanri Wijayanti Subronto, Agus Surono","doi":"10.1080/00016489.2026.2640609","DOIUrl":"10.1080/00016489.2026.2640609","url":null,"abstract":"Background: Deep neck abscess (DNA) is a otorhinolaryngological condition associated with morbidity, mortality, high treatment costs, and long-term wound care. Optimizing wound management is essential to improve outcomes and reduce healthcare burden. Honey is expected to be an effective treatment modality and may serve as an effective adjunctive therapy.Objective: To compare the effectiveness of standard wound dressing combined with honey versus standard dressing in patients with DNA, based on wound size, Bates-Jensen Wound Assessment Tool (BWATs) scores, Visual Analog Scale (VAS), white blood cell (WBC) count, bacterial colony growth, and expression of interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor (VEGF).Methods: A single-blind randomized controlled trial was conducted at Dr. Sardjito General Hospital between May 2024 and June 2025. Participants received either standard dressing or standard dressing supplemented with honey. Outcomes were analyzed using appropriate parametric and nonparametric statistical methods.Results: Honey supplementation showed comparable clinical outcomes to standard dressings, demonstrated greater reductions in inflammatory markers (IL-1, TNF-α) and increased VEGF expression.Conclusion: Honey as an adjunct to standard dressing may serve as an effective adjunct DNA wound healing by enhancing anti-inflammatory and proliferative responses.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"879-886"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term hearing outcomes and determinants on patient-perceived benefits after bone cement fixation in stapedotomy. 镫骨切开术中骨水泥固定后的长期听力结果和患者感知获益的决定因素。

IF 1.3 4区医学

Acta Oto-Laryngologica Pub Date : 2026-07-01 Epub Date: 2026-03-05 DOI: 10.1080/00016489.2026.2638513

Fazıl Necdet Ardıç, Gökçe Aydemir, Berk Oktar, Samir İbrahimli, Esra Şafak Eren, Cüneyt Orhan Kara

{"title":"Long-term hearing outcomes and determinants on patient-perceived benefits after bone cement fixation in stapedotomy.","authors":"Fazıl Necdet Ardıç, Gökçe Aydemir, Berk Oktar, Samir İbrahimli, Esra Şafak Eren, Cüneyt Orhan Kara","doi":"10.1080/00016489.2026.2638513","DOIUrl":"10.1080/00016489.2026.2638513","url":null,"abstract":"Background: Stapes surgery using Teflon prostheses is widely performed for otosclerosis; however, prosthesis dislocation has been reported in approximately 3.5% of cases within the first two postoperative years.Aims/objective: To evaluate the seven-year audiological and patient-reported outcomes of stapedotomy with bone cement fixation.Methods: This retrospective cohort study with prospective follow-up included patients who underwent stapedotomy with bone cement fixation between 2012 and 2022. Air conduction and bone conduction thresholds were assessed at short-term (0-1 years), mid-term (1-4 years), and long-term (4- years) follow-up. Patient-reported outcomes were evaluated using a procedure-specific questionnaire and the Glasgow Benefit Inventory (GBI).Results: Postoperative ABG improved significantly (p < 0.001) and remained stable during long-term. Progressive elevation in bone conduction thresholds was observed in both operated and contralateral ears. The mean GBI score was 47.5 ± 34.2, with 89% of patients reporting moderate to substantial benefit. Perceived benefit and willingness to recommend surgery were negatively associated with hospitalization difficulties, hearing aid use, and lifestyle limitations, and positively associated with tinnitus improvement and higher GBI scores.Conclusions: Bone cement fixation in stapedotomy provides durable long-term hearing outcomes without adverse effects. Patient-perceived benefit is primarily determined by stable ABG closure and limited progression of sensorineural hearing loss.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"858-863"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic epidemiology of Moroccan pediatric cochlear implantation patients. 摩洛哥儿童人工耳蜗植入患者的遗传流行病学。

IF 1.3 4区医学

Acta Oto-Laryngologica Pub Date : 2026-07-01 Epub Date: 2026-03-26 DOI: 10.1080/00016489.2026.2634188

El Mostafa Salman, Omar Oulghoul, Mohammed Chehbouni, Youssef Lakhdar, Youssef Rochdi, Meriem El Qabli, Bouzid Fatimazahra, Maria Mansouri, Nisrine Aboussair, Abdelaziz Raji, Shin-Ya Nishio, Shin-Ichi Usami

{"title":"Genetic epidemiology of Moroccan pediatric cochlear implantation patients.","authors":"El Mostafa Salman, Omar Oulghoul, Mohammed Chehbouni, Youssef Lakhdar, Youssef Rochdi, Meriem El Qabli, Bouzid Fatimazahra, Maria Mansouri, Nisrine Aboussair, Abdelaziz Raji, Shin-Ya Nishio, Shin-Ichi Usami","doi":"10.1080/00016489.2026.2634188","DOIUrl":"10.1080/00016489.2026.2634188","url":null,"abstract":"Background: Hearing loss is a significant global health concern, with genetic factors accounting for up to 60% of congenital or prelingual onset deafness. Cochlear implantation is widely used as an effective treatment for patients with severe-to-profound hearing loss; however, the genetic background in Moroccan cochlear implant patients remains unclear.Aims/objectives: This study investigates the genetic background of congenital or pre-lingual onset severe-to-profound sensorineural hearing loss in pediatric patients who received cochlear implantation.Material and methods: In this study, we enrolled 88 patients who underwent cochlear implantation and genetic diagnosis using next-generation sequencing with a panel covering 158 previously reported causative genes.Results: We identified the genetic cause in 58 of the 88 patients, with a genetic diagnostic rate of 65.9%. We identified 28 genes associated with Moroccan pediatric cochlear implant patients. The most prevalent genetic cause identified in this study was the GJB2 gene (12.5%), followed by MYO7A (6.8%) and CDH23 (4.5%).Conclusions and significance: The study highlights the importance of genetic screening in pediatric cochlear implant patients and underscores the potential of gene therapy for treating genetic hearing loss.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"771-782"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0