Acta Oto-Laryngologica最新文献_第9页

Actinomyces status and inflammatory biomarkers in post-tonsillectomy hemorrhage cases. 扁桃体切除术后出血病例中的放线菌状态和炎症生物标志物。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-10-26 DOI: 10.1080/00016489.2024.2410330

Burak Hazır, Zeliha Berfu Kastal, Eray Uzunoğlu

{"title":"Actinomyces status and inflammatory biomarkers in post-tonsillectomy hemorrhage cases.","authors":"Burak Hazır, Zeliha Berfu Kastal, Eray Uzunoğlu","doi":"10.1080/00016489.2024.2410330","DOIUrl":"10.1080/00016489.2024.2410330","url":null,"abstract":"Background: The presence of Actinomyces can be associated with complications.Aims: This study aimed to determine the frequency of post-tonsillectomy hemorrhage (PTH), the presence of Actinomyces in palatine tonsils and serum inflammatory biomarker levels in PTH.Material and methods: The cases who underwent tonsillectomy at a single center were included in the study. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) values were calculated from the complete blood count test. The presence of Actinomyces was recorded from histopathological tonsillectomy material.Results: A total of 1137 patients were included in the study. Actinomyces was detected in 93 (8.18%) patients. Bleeding complications were encountered in 65 cases (5.72%). No relationship was detected between the presence of Actinomyces and PTH rates (p = 0.433). While a relationship was found between age, NLR, and SIRI values and Actinomyces status (respectively, p < 0.001, p = 0.017, p = 0.038), no statistically significant relationship was found between tonsil size, PLR, and SII (p > 0.05).Conclusion and significance: According to the data in our study, NLR and SIRI values were elevated in subjects with Actinomyces. Our findings suggest that this entity has a systemic manifestation. Serum inflammatory biomarkers and the presence of Actinomyces were not found to be associated with PTH.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"641-645"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extent of abscess development in cervical abscesses and pathogenic bacteria related to swallowing function. 宫颈脓肿的脓肿发展程度以及与吞咽功能有关的致病菌。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-11-14 DOI: 10.1080/00016489.2024.2425764

Aya Katsura, Ryoukichi Ikeda, Masato Suzuki, Iori Kusaka, Shinsuke Kaneshiro, Toshihiko Abe, Shigeru Kuwashima, Katsunori Katagiri, Jun Suzuki, Kiyoto Shiga

{"title":"Extent of abscess development in cervical abscesses and pathogenic bacteria related to swallowing function.","authors":"Aya Katsura, Ryoukichi Ikeda, Masato Suzuki, Iori Kusaka, Shinsuke Kaneshiro, Toshihiko Abe, Shigeru Kuwashima, Katsunori Katagiri, Jun Suzuki, Kiyoto Shiga","doi":"10.1080/00016489.2024.2425764","DOIUrl":"10.1080/00016489.2024.2425764","url":null,"abstract":"Background: Deep neck infections (DNIs) in the cervical fascial planes can cause severe complications such as airway obstruction, mediastinitis, and sepsis.Aims/objectives: This study examines cervical abscess development, its relationship with postoperative swallowing function, and hospital stay duration.Material and methods: A retrospective case series of 55 DNI patients was divided by hospital stay (<30 days: Group A, ≥30 days: Group B) and swallowing recovery (<6 days: Group C, ≥6 days: Group D). Swallowing was assessed using FOIS; abscesses were categorized via CT and surgery.Results: Longer hospital stays (Group B) were associated with tracheostomy (p = .027) and thoracoscopic mediastinal drainage (p = .038), shorter time between symptom onset and surgery (p = .016), and abscesses in the anterior cervical (p = .007), retropharyngeal space (p = .026), and mediastinal spaces (p = .002). Dysphagia (Group D) was linked to longer hospital stays (p = .006), more abscesses in the anterior cervical (p = .049) and retropharyngeal spaces (p = .009), and higher cases of intubated feeding (p < .001). Streptococcus constellatus was more prevalent in Group D (p = .04), whereas Staphylococcus aureus was less common (p = .043).Conclusions and significance: Dysphagia is associated with abscesses in the anterior cervical and retropharyngeal spaces and higher Streptococcus constellatus prevalence, indicating delayed oral intake recovery. Thoracoscopic mediastinal drainage and shorter time to surgery were linked to prolonged hospital stays.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"657-662"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of fast-track on recurrence and malignant transformation of patients with inverted papilloma. 快速通道对倒置乳头状瘤患者复发和恶变的影响。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI: 10.1080/00016489.2024.2408741

Kasper Gydesen, Rasmus Bülow, Kasper Aanaes, Anne Fog Lomholt, Tina Agander, Christian von Buchwald, Sannia Sjöstedt

{"title":"Impact of fast-track on recurrence and malignant transformation of patients with inverted papilloma.","authors":"Kasper Gydesen, Rasmus Bülow, Kasper Aanaes, Anne Fog Lomholt, Tina Agander, Christian von Buchwald, Sannia Sjöstedt","doi":"10.1080/00016489.2024.2408741","DOIUrl":"10.1080/00016489.2024.2408741","url":null,"abstract":"Background: Inverted papilloma is a benign epithelial tumour located in the sinonasal tract with a high recurrence rate and a potential of malignant transformation. From 2017, patients with IP were included in our fast-track regime similar to head and neck cancer patients, including follow-up at 2, 6, 12, 18 and 24 months after surgery, then yearly for a total of 5 years.Aims/objectives: This study aims to compare the recurrence rate and malignant transformation of patients with IP treated at a university centre following the implementation of a fast-track regime including a close follow-up.Methods: A retrospective study was performed on all patients with IP diagnosed between 2018 and 2022.Results: The study included 125 patients, all surgically treated for IP. Eight patients (6%) also presented with SCC at the time of diagnosis. The recurrence rate of benign IP was 17%. Most tumours originated in the maxillary sinus (48/117, 41%). No cases of metachronous cancer were seen during the follow-up.Conclusions and significance: The majority of recurrences (90%) occurred within the first 2 years after treatment. No cases of malignant transformation were seen in the follow-up period. The rigorous follow-up program potentially contributed to the detection of recurrence before malignant transformation.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"631-634"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic rhinosinusitis with nasal polyps: predictors of recurrence 5 years after surgery. 伴有鼻息肉的慢性鼻炎：术后 5 年复发的预测因素。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-11-15 DOI: 10.1080/00016489.2024.2424962

Pedro Marques Gomes, Diogo Cunha Cabral, Joana Barreto, André Alves Carção, Delfim Duarte, José Ferreira Penêda

{"title":"Chronic rhinosinusitis with nasal polyps: predictors of recurrence 5 years after surgery.","authors":"Pedro Marques Gomes, Diogo Cunha Cabral, Joana Barreto, André Alves Carção, Delfim Duarte, José Ferreira Penêda","doi":"10.1080/00016489.2024.2424962","DOIUrl":"10.1080/00016489.2024.2424962","url":null,"abstract":"Backgrounds: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a medical condition characterized by persistent inflammation of the nasal mucosa and sinuses, accompanied by the presence of nasal polyps. When medical treatments prove ineffective, endoscopic sinus surgery (ESS) is recommended, yielding variable outcomes and recurrence rates ranging from 5% to 60%.Aims/objectives: The primary objectives of this study were to evaluate the outcomes of ESS and to identify independent predictors of recurrence and revision surgery.Material and methods: Retrospective cross-sectional study, focusing on patients diagnosed with CRSwNP who underwent ESS with a minimum follow-up period of 60 months. Various variables were collected. Multivariate and regression analyses were employed to assess the predictors associated with both recurrence and revision surgery.Results: The study analyzed 130 patients. The 5-year recurrence rate was 35.4%, and 17.7% of patients required revision surgery. These variables included asthma (p < 0.001), frontal sinus involvement (p < 0.001), Lund-Mackay score (p < 0.001), Endoscopic Nasal Polyps Score (p < 0.001), and eosinophilia in peripheral blood (p < 0.001). All the variables mentioned above were identified as predictors of recurrence and revision surgery.Conclusions and significance: Asthma, frontal sinus involvement, increased eosinophilia in peripheral blood, and a higher score on the LM system and NPS are poor prognostic factors in CRSwNP.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"635-640"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic versus microscopic approach in the treatment of atelectatic otitis media. 治疗失聪性中耳炎的内窥镜方法与显微镜方法。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-11-01 Epub Date: 2024-11-25 DOI: 10.1080/00016489.2024.2424947

Giannicola Iannella, Annalisa Pace, Antonio Greco, Armando De Virgilio, Lodovica Gatti, Antonino Maniaci, Jerome R Lechien, Rémi Hervochon, Ali Faramarzi, Quentin Mat, Maryana Cherkes, Matthias Koiner-Graupp, Paolo Boscolo-Rizzo, Luigi Angelo Vaira, Giuseppe Magliulo

{"title":"Endoscopic versus microscopic approach in the treatment of atelectatic otitis media.","authors":"Giannicola Iannella, Annalisa Pace, Antonio Greco, Armando De Virgilio, Lodovica Gatti, Antonino Maniaci, Jerome R Lechien, Rémi Hervochon, Ali Faramarzi, Quentin Mat, Maryana Cherkes, Matthias Koiner-Graupp, Paolo Boscolo-Rizzo, Luigi Angelo Vaira, Giuseppe Magliulo","doi":"10.1080/00016489.2024.2424947","DOIUrl":"10.1080/00016489.2024.2424947","url":null,"abstract":"Background: endoscopic ear surgery in patients Chronic Otitis Media(COM) media with eardrum atelectasis.Objective: to compare the postoperative outcomes and audiological results of the endoscopic approach versus the microscopic approach for treatment of COM media with eardrum atelectasis, using a randomized prospective model.Methods: Sixty patients were consecutively enrolled in the study and randomized into two groups: Group A 32 patients underwent canal wall up tympanoplasty (CWA); Group B 28 patients underwent tympanoplasty with an exclusive trans-meatal endoscopic approach. Audiological results and preoperative, intraoperative and postoperative outcomes were evaluated.Results: No statistical difference emerged between distribution of middle ear atelectasis patients grade 3 and 4 between the two surgical groups (p > 0.05). The group B appeared to have shorter surgical times than group A (69.8 min vs. 88.9 min). The graft success rate was estimated in 90.6% and 92.8% in group A and B respectively, without statistical differences between groups (p = 1). The Overall success rate was therefore calculated in 87.5% and 92.8% for both groups.Conclusion and significance: Endoscopic ear surgery could be a suitable approach for treating COM media with eardrum atelectasis with similar results compared with the Microscopic surgery.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"592-601"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do different types of cochlear implant electrode influence hearing preservation and speech perception? 不同类型的人工耳蜗电极会影响听力保护和言语感知吗？

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-10-01 DOI: 10.1080/00016489.2024.2407395

Karin Hallin, Ulrika Larsson, Nadine Schart-Morén

{"title":"Do different types of cochlear implant electrode influence hearing preservation and speech perception?","authors":"Karin Hallin, Ulrika Larsson, Nadine Schart-Morén","doi":"10.1080/00016489.2024.2407395","DOIUrl":"10.1080/00016489.2024.2407395","url":null,"abstract":"Background: Hearing can be preserved in patients with considerable low-frequency hearing implanted with cochlear implants. However, the most favorable electrode type for hearing preservation and speech perception has been debated.Objective: The aim was to evaluate hearing preservation and speech discrimination one year post-implantation for all types of cochlear implant electrode used for adult patients implanted between 2014 and 2022.Methods: The HEARING group formula was used to calculate the degree of hearing preservation, which was defined as minimal (0-25%), partial (25-75%) or complete (≥ 75%). Speech perception was measured by monosyllabic words.Results: Analysis of hearing preservation for the various electrode types revealed that FLEX 24 preserved hearing statistically significantly better (p < 0.05) than FLEX 28, FLEX soft, and contour advance. Also, FLEX 20 preserved hearing statistically significantly better (p < 0.05) than contour advance. No statistically significant difference was found for the monosyllabic word score for the different electrode types.Discussion: There was a statistically significant difference between the electrode types in terms of hearing preservation but not for speech perception. The result of this study contributes important information about hearing preservation and speech perception that can be used for pre-surgery patient counselling.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"552-557"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hearing and balance functions in patients with systemic lupus erythematosus. 系统性红斑狼疮患者的听力和平衡功能。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-10-01 Epub Date: 2024-10-21 DOI: 10.1080/00016489.2024.2416934

Serpil Demir, Anı Parabakan Polat, Cevahir Bulut Turay, Selim Sermed Erbek

{"title":"Hearing and balance functions in patients with systemic lupus erythematosus.","authors":"Serpil Demir, Anı Parabakan Polat, Cevahir Bulut Turay, Selim Sermed Erbek","doi":"10.1080/00016489.2024.2416934","DOIUrl":"10.1080/00016489.2024.2416934","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is a chronic, inflammatory, autoimmune disease, characterized by multiple organ involvement, which is seen more often in young females.Objectives: To evaluate the hearing and balance functions in SLE patients.Materials and methods: Twenty-four SLE patients, 24 healthy controls underwent pure tone audiometry (0.125-16 kHz), VNG, vestibular evoked myogenic potential (VEMP), and video head impulse test (vHIT).Results: A statistically significant difference was determined between the control group and the SLE group at 0.125, 0.25, 0.5, 1.0, 6.0, 8.0, 10, 12, 14, and 16 kHz frequencies. Sensorineural hearing loss was observed in 37.5% of the SLE group. The pursuit test was pathological at the rate of 25% in the SLE group. No response was obtained in six SLE patients in the oVEMP test and four SLE patients in the cVEMP test. The mean posterior SCC VOR gain values were 0.64 ± 0.2 in the SLE group. A significant difference was determined between the groups with respect to posterior SCC VOR gains.Conclusions and significance: Our findings show that SLE disease may negatively affect the hearing system and the vestibular system as well. The current study is the first study to comprehensively evaluate SLE patients with VNG, VEMP, and vHIT tests.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"565-569"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The quantification and mRNA expression levels of cochlear synapses in C57BL/6j mice following repeated exposure to noise. 反复暴露于噪声后 C57BL/6j 小鼠耳蜗突触的定量和 mRNA 表达水平。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-10-01 Epub Date: 2024-10-21 DOI: 10.1080/00016489.2024.2413385

Minfei Qian, Zhuowei Yao, Qixuan Wang, Yaqi Zhou, Zhiwu Huang, Jiping Li

{"title":"The quantification and mRNA expression levels of cochlear synapses in C57BL/6j mice following repeated exposure to noise.","authors":"Minfei Qian, Zhuowei Yao, Qixuan Wang, Yaqi Zhou, Zhiwu Huang, Jiping Li","doi":"10.1080/00016489.2024.2413385","DOIUrl":"10.1080/00016489.2024.2413385","url":null,"abstract":"Background: Noise-induced cochlear synaptopathy has recently emerged as a focus in hearing research.Purpose: This study aimed to examine the impact of repeated noise exposure on the quantification and mRNA expression levels of cochlear synapses.Methods: Measurements were conducted at baseline, 1 day, and 14 days post-exposure to 88 or 97 dB SPL noise (2 h/day for 7 days, frequency range 2-20 kHz). Auditory brainstem responses (ABRs), immunofluorescence and quantitative real-time PCR (qRT-PCR) were used to examine the results.Results: 1. Exposure to 88 dB SPL caused minimal changes in ABRs, ribbon morphology and medial olivocochlear (MOC) efferent synapses; elevation of synaptophysin(SYP) and α9α10 nAchR mRNA levels were observed. 2. Exposure to 97 dB SPL caused threshold shift and synaptopathy of ribbon and MOC; downregulation of α10nAchR, SYP and ctbp2 mRNA levels were observed.Conclusion: Noise-induced cochlear synaptic degeneration involves both afferent and efferent synaptopathy.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"558-564"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical value of wideband acoustic immittance in the diagnosis of otitis media with effusion under negative intratympanic pressure in adults. 宽带声沉在诊断成人鼓室负压下伴有流脓的中耳炎中的临床价值。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-10-01 Epub Date: 2024-10-22 DOI: 10.1080/00016489.2024.2414801

Ao Li, Xuan Yang, Yuqin Xu, Ning Zhao, Xueyao Liu, Haoliang Du, Jifeng Xu, Xia Gao, Ye Yang

{"title":"Clinical value of wideband acoustic immittance in the diagnosis of otitis media with effusion under negative intratympanic pressure in adults.","authors":"Ao Li, Xuan Yang, Yuqin Xu, Ning Zhao, Xueyao Liu, Haoliang Du, Jifeng Xu, Xia Gao, Ye Yang","doi":"10.1080/00016489.2024.2414801","DOIUrl":"10.1080/00016489.2024.2414801","url":null,"abstract":"Background: Normative clinical values for wideband acoustic immittance (WAI) are not well-established.Aims: This study aims to define the normative contour plot characteristics of WAI and evaluate its diagnostic value in detecting tympanic effusion.Materials and methods: Data were collected from subjects with normal hearing (76 ears) and type C tympanograms on 226-Hz tympanometry (130 ears). Matlab was used to process and analyze the data. The maximum absorbance of WAI was used as the primary indicator, and the receiver operating characteristic (ROC) curve was drawn to determine the optimal cut-off value. WAI contour plots were compared to 226-Hz tympanometry and otoendoscopy, the latter being the gold standard.Results: Mean WAI plots in the normal group showed single peaks (absorbance, >70%) and a nearly symmetrical distribution of the peak area around the 0 daPa pressure line. The ROC curve indicated an AUC value of 0.910, with 78% as the optimal cut-off value of maximum absorbance for detecting effusion. WAI demonstrated better diagnostic performance (sensitivity: 82.26%, specificity: 86.76%, kappa: 0.691) than 226-Hz tympanometry (sensitivity: 61.29%, specificity: 61.76%, kappa: 0.230).Conclusions and significance: Normative WAI values were established, and WAI proved more accurate than 226-Hz tympanometry for identifying tympanic effusion, offering valuable guidance for selecting treatment options.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"533-541"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2024-10-01 Epub Date: 2024-10-03 DOI: 10.1080/00016489.2024.2407402

Toshiyuki Matsuyama, Mizuki Sakurai, Kazuaki Chikamatsu

{"title":"Dupilumab-related late adverse events in patients with chronic rhinosinusitis with nasal polyps.","authors":"Toshiyuki Matsuyama, Mizuki Sakurai, Kazuaki Chikamatsu","doi":"10.1080/00016489.2024.2407402","DOIUrl":"10.1080/00016489.2024.2407402","url":null,"abstract":"Background: Anti-IL-4 receptor α antibody (dupilumab) has demonstrated favorable sinonasal outcomes for chronic rhinosinusitis with nasal polyps (CRSwNP), which is mainly caused by type 2 inflammation. Although increased blood eosinophil levels and injection site symptoms are frequently observed as acute adverse events (AEs) of dupilumab, limited knowledge is available regarding the late AEs of dupilumab for CRSwNP.Objectives: We investigated the late AEs following the initiation of dupilumab treatment for CRSwNP.Material and methods: Fifty-one patients with CRSwNP treated with dupilumab for > 3 months were enrolled, and their clinical data were collected from their medical records.Results: Six (11.8%) patients experienced late AEs. One case of eczema with pruritus, one case of psoriasis-like dermatitis, two cases of severe rash, one case of malignant lymphoma, and one case of alopecia areata were observed. Skin disorders were the most common late AEs in this study. It is a Th1-inflammatory disease, and its mechanism is thought to be due to the immune imbalance caused by dupilumab. We could not confirm whether malignant lymphoma in our case was caused by dupilumab use.Conclusions and significance: Skin disorders are often late AEs associated with dupilumab; therefore, careful monitoring after dupilumab initiation should be considered.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"570-573"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0