Acta Oto-Laryngologica最新文献_第9页

A trend of otologic diseases during the coronavirus disease 2019 pandemic period. 2019冠状病毒病大流行期间耳科疾病趋势分析

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1080/00016489.2025.2459343

Hye Ah Joo, Byung Chul Kang, Tae Su Kim, Woo Seok Kang, Hong Ju Park, Jong Woo Chung, Joong Ho Ahn

{"title":"A trend of otologic diseases during the coronavirus disease 2019 pandemic period.","authors":"Hye Ah Joo, Byung Chul Kang, Tae Su Kim, Woo Seok Kang, Hong Ju Park, Jong Woo Chung, Joong Ho Ahn","doi":"10.1080/00016489.2025.2459343","DOIUrl":"10.1080/00016489.2025.2459343","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) changed the practice of medicine, and various anti-contagion restrictions were implemented worldwide.Objectives: This study aimed to evaluate the annual trend in the incidence of otologic diseases during the COVID-19 pandemic and determine the influence of social restrictions on these diseases.Materials and methods: We retrospectively reviewed the number of patients treated for otologic diseases, particularly those associated with infectious pathophysiology, and the total number of patients in the otolaryngology departments at three tertiary referral centers in South Korea.Results: The number of patients who underwent ventilation tube insertion due to persistent otitis media with effusion (OME) significantly decreased (raw number: -37.1%, incidence: -2.04‰) after the onset of the COVID-19 pandemic. However, a sharp increase was observed in 2023 (raw number: +42.9%, incidence: +1.63‰) when the pandemic officially ended. The number of patients newly diagnosed with sudden sensorineural hearing loss (SSNHL) gradually increased during the pandemic period.Conclusions and significance: Restrictive measures to control COVID-19 spread positively influenced the reduction in the incidence of OME. Whether COVID-19 is a direct risk factor for SSNHL remains uncertain, but the potential impact of the virus itself or the COVID-19 vaccine on the auditory system appears to exist.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"277-282"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Added value of HPV-DNA in situ hybridization as an adjunct to p16 Immunohistochemistry in oropharyngeal squamous cell carcinoma. HPV-DNA原位杂交辅助p16免疫组化在口咽鳞状细胞癌中的附加价值。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI: 10.1080/00016489.2025.2461653

Linda Nissi, Teemu Huusko, Johannes Routila, Samuli Vaittinen, Ilmo Leivo, Heikki Irjala, Sami Ventelä

{"title":"Added value of HPV-DNA in situ hybridization as an adjunct to p16 Immunohistochemistry in oropharyngeal squamous cell carcinoma.","authors":"Linda Nissi, Teemu Huusko, Johannes Routila, Samuli Vaittinen, Ilmo Leivo, Heikki Irjala, Sami Ventelä","doi":"10.1080/00016489.2025.2461653","DOIUrl":"10.1080/00016489.2025.2461653","url":null,"abstract":"Background: Current guidelines recommend p16 immunohistochemistry (IHC) for testing human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OPSCC). The need for additional HPV-DNA testing is debated.Aims/objectives: We evaluated the prognostic value of HPV-DNA in situ hybridization (ISH) as an adjunct to p16.Material and methods: A population-based cohort of 1,033 head and neck squamous cell carcinoma patients was used, to identify 124 OPSCC patients treated with a curative intent.Results: Of the p16-positive patients, 17.9% did not show evidence for presence of HPV-DNA in ISH. Both p16 and HPV-DNA ISH were significant prognostic factors for overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS) when used independently. When combining information from p16 IHC and HPV-DNA ISH, survival of the p16+/ISH- discordant patients was intermediate compared to the p16+/ISH+ and p16-/ISH- groups. In the discordant group, smoking was a strong prognostic determinator, with non-smokers having an outstanding prognosis.Conclusions and significance: Both p16 IHC and HPV-DNA ISH perform well as separate prognostic biomarkers for OS, DSS, and DFS on a population level. However, a discordant group does exist. Limiting HPV-DNA testing for p16-positive patients who smoke by the time of diagnosis may be a cost-efficient and justified solution.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"340-347"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of early test termination in a German matrix speech test in noise in cochlear implant recipients. 人工耳蜗受者在噪声环境下的德语矩阵语音测试中早期测试终止的影响。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-20 DOI: 10.1080/00016489.2025.2454479

Christoph Schmid, Martin Kompis, Wilhelm Wimmer

{"title":"Effects of early test termination in a German matrix speech test in noise in cochlear implant recipients.","authors":"Christoph Schmid, Martin Kompis, Wilhelm Wimmer","doi":"10.1080/00016489.2025.2454479","DOIUrl":"https://doi.org/10.1080/00016489.2025.2454479","url":null,"abstract":"Background: Speech reception thresholds (SRTs) can be estimated with speech in noise tests using adaptive procedures. Since these tests are time-consuming, it is preferable to use as few trials as possible to identify reliable results.Aims/objectives: To estimate the impact of early test termination in a German matrix speech test in noise (Oldenburger Satztest) on SRT estimation after 20 instead of after 30 sentences and to identify groups of subjects, for who such a tradeoff between measurement time and accuracy might be useful and acceptable.Material and methods: Retrospective analysis of 789 tests from cochlear implant users and from simulated tests in 10000 virtual subjects.Results: Early test termination results in increased estimation errors of the SRT in both real, and simulated listeners. Average test time is reduced from 5.0 to 3.6 min. For estimated SRT's above approximately +2 dB after 20 test sentences, the expected average difference to the result after 30 trials becomes higher than 0.5 dB.Conclusions and significance: If adaptive speech in noise tests are terminated already after 20 sentences, time can be saved, but it should be considered only in listeners with relatively favourable SRT-estimates after 20 trials, preferably below +2 dB.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparation on vestibular function during the perioperative period in pediatric cochlear implant patients with and without large vestibular aqueduct syndrome. 伴有和不伴有大前庭导水管综合征的儿童人工耳蜗围手术期前庭功能的比较。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-07 DOI: 10.1080/00016489.2024.2447046

Yanhong Li, Bing Liu, Yang Yang, Min Chen, Wei Liu, Ning Ma, Jie Zhang, Xin Ni

{"title":"Comparation on vestibular function during the perioperative period in pediatric cochlear implant patients with and without large vestibular aqueduct syndrome.","authors":"Yanhong Li, Bing Liu, Yang Yang, Min Chen, Wei Liu, Ning Ma, Jie Zhang, Xin Ni","doi":"10.1080/00016489.2024.2447046","DOIUrl":"https://doi.org/10.1080/00016489.2024.2447046","url":null,"abstract":"Backgrounds: It remains unclear whether LVAS pediatric patients experience more severe subjective symptoms after surgery compared to other pediatric patients, whether their objective vestibular function is worse, and the underlying reasons for their poorer subjective experience.Objectives: To compare vestibular function following CI between pediatric pediatric patients with and without LVAS.Materials and methods: The study included 11 patients in the LVAS group(18.42 ± 2.4 month) and 24 patients in the NLVAS group(35.73 ± 11.40 month). A comprehensive assessment of vestibular function was conducted both preoperatively and postoperatively. The assessment included vestibular function tests and evaluation of vestibular-related symptoms. The vestibular function test was conducted using cervical vestibular evoked myogenic potentials (cVEMP).Results: A higher incidence of postoperative dizziness was reported in the LVAS group compared to the NLVAS group (63.63% vs 0.08%, p = 0.001). The LVAS group exhibited a prolonged recovery period for head lifting and sitting compared to the NLVAS group (3.27 ± 0.715 vs 1.42 ± 0.119 days, p = 0.027; 4.09 ± 1.217 vs 1.92 ± 0.219 days, p = 0.022, respectively). The elicitation rate and amplitude of cVEMP in LVAS children showed no significant difference when compared to the NLVAS group preoperatively (p > 0.05). The LVAS group had a more decrease in amplitude 5 days after surgery compared to the NLVAS group (142.09 ± 33.98 vs 81.89 ± 17.13, p = 0.039).Conclusion: Pediatric patients with LVAS are more prone to experiencing dizziness symptoms post- CI surgery. There is an increased fluctuation in amplitude of cVEMP in LVAS pediatric patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Which is superior, the University of Pennsylvania Smell Identification Test or the threshold, Discrimination and Identification Test for testing human olfaction? A systematic review. 宾夕法尼亚大学嗅觉识别测试与阈值、辨别和识别测试在测试人类嗅觉方面孰优孰劣？系统综述。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-05 DOI: 10.1080/00016489.2025.2458170

Magne Bech, Kathrine Kronberg Jakobsen, Ida Schlosshauer Brandt Andersen, Christian Korsgaard Pedersen, Mathias Waldemar Grønlund, Christian von Buchwald

{"title":"Which is superior, the University of Pennsylvania Smell Identification Test or the threshold, Discrimination and Identification Test for testing human olfaction? A systematic review.","authors":"Magne Bech, Kathrine Kronberg Jakobsen, Ida Schlosshauer Brandt Andersen, Christian Korsgaard Pedersen, Mathias Waldemar Grønlund, Christian von Buchwald","doi":"10.1080/00016489.2025.2458170","DOIUrl":"https://doi.org/10.1080/00016489.2025.2458170","url":null,"abstract":"Background: The awareness and prevalence of olfactory dysfunction (OD) has increased significantly in recent years, with the SARS-CoV-2 pandemic being a major catalyzer. Consequently, demands for reliable OD tests have also risen.Aims: This systematic review compares two commonly used tests for olfactory assessment: the University of Pennsylvania Smell Identification Test (UPSIT) and the Threshold, Discrimination, and Identification test (TDI). The correlation between UPSIT, TDI, and the Visual Analogue Scale (VAS) for olfaction is also examined.Material and methods: A systematic search of PubMed and EMBASE identified articles validating UPSIT or TDI and comparing these to self-reported OD via VAS. The outcome of interest was test-retest validity and correlation.Results: The search identified 1536 studies, with nine meeting inclusion criteria. UPSIT showed a 'very strong' test-retest correlation, while TDI showed a 'strong' correlation. One study addressed VAS in relation to UPSIT and five for TDI. Correlation coefficients varied between VAS and TDI/UPSIT.Conclusions and significans: UPSIT and TDI exhibited strong to very strong test-retest reliability. Due to the limited number of studies, a meta-analysis was not feasible, and neither test was found to be superior in reliability. VAS did not correlate significantly with either TDI or UPSIT.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-4"},"PeriodicalIF":1.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of nasal septum deviation on the sphenoid bone pneumatization: a retrospective computed tomography study. 鼻中隔偏曲对蝶骨充气的影响：回顾性计算机断层扫描研究。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-04 DOI: 10.1080/00016489.2025.2455761

Jiajun Tang, Jie Hou, Yanshu Zhang, Xin Dou, Handong Wang, Xianmei Wei, Xinyan Cui, Zhengrong Xu, Chenjie Yu

{"title":"Impact of nasal septum deviation on the sphenoid bone pneumatization: a retrospective computed tomography study.","authors":"Jiajun Tang, Jie Hou, Yanshu Zhang, Xin Dou, Handong Wang, Xianmei Wei, Xinyan Cui, Zhengrong Xu, Chenjie Yu","doi":"10.1080/00016489.2025.2455761","DOIUrl":"https://doi.org/10.1080/00016489.2025.2455761","url":null,"abstract":"Background: Deviated nasal septum (DNS) changes aerodynamic airflow pattern and increases nasal resistance that may affect paranasal sinus pneumatization.Objectives: To explore the relationships among DNS, sphenoid bone pneumatization and surrounding neurovascular structures.Material and methods: The paranasal sinus CT images of DNS patients (n = 100) and patients without DNS (n = 60) between 2020 and 2022 were retrospectively analyzed. Sphenoid bone pneumatization and anterior clinoid processes (ACP) length were measured while surrounding neurovascular structure types were assessed.Results: In the DNS group, the indicators demonstrating sphenoid bone pneumatization were significantly (p < 0.001) greater than that in the control group. There were no statistically significant differences in the indicators demonstrating the positions of vidian canal (VC) and foramen rotundum (FR) between two groups. Regarding proportion of different neurovascular structure grades, the findings were significant (p < 0.05) between two groups. The corrected sphenoid sinus area also correlated with surrounding neurovascular structure types.Conclusions and significance: Severe DNS is significantly related to the sphenoid bone pneumatization and surrounding neurovascular structure. This suggests that clinicians should be aware of the anatomical variation of sphenoid bone pneumatization and the cranial base structures in DNS patients.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Features and prognostic factors in pediatric deep neck infections: a retrospective study. 小儿颈深部感染的临床特征和预后因素：一项回顾性研究。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-04 DOI: 10.1080/00016489.2025.2458738

Zehra Betül Paksoy, Melih Cayonu, Ali Demir

{"title":"Clinical Features and prognostic factors in pediatric deep neck infections: a retrospective study.","authors":"Zehra Betül Paksoy, Melih Cayonu, Ali Demir","doi":"10.1080/00016489.2025.2458738","DOIUrl":"https://doi.org/10.1080/00016489.2025.2458738","url":null,"abstract":"Background: Pediatric deep neck abscesses (PDNAs) are uncommon but can cause serious complications. Despite advances in diagnostics and antibiotic therapies, effective PDNA management remains challenging, necessitating prompt diagnosis and targeted treatment.Objectives: This study evaluated the clinical characteristics, treatment approaches, and factors affecting hospital stay in pediatric patients with PDNAs. Associations between laboratory markers (hemoglobin, albumin, inflammatory indices) and abscess characteristics with clinical outcomes were analyzed.Methods: A retrospective review of 72 PDNA cases at Ankara Bilkent City Hospital (2019-2024) was performed. Clinical presentation, laboratory findings (hemoglobin, albumin), abscess size, and inflammatory indices (SII, NLR, SIRI) were analyzed.Results: The mean age was 6.69 years, with 51.38% under six. Peritonsillar abscesses were the most common (40.3%), followed by retropharyngeal abscesses. Antibiotic therapy alone was successful in 33.3% of cases, while 66.7% required surgical drainage. Prolonged hospitalization was associated with low hemoglobin (p = .003) and albumin (p = .034), larger abscess size (p = .047), and elevated inflammatory markers (SIRI: p = .007, SII: p = .015).Conclusions and significance: Prognostic factors such as hemoglobin, albumin, and inflammatory indices is essential in PDNA management. Surgical intervention plays a key role in severe cases, emphasizing the need for standardized protocols.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-evaluating Epstein-Barr virus, human papilloma virus, human cytomegalovirus and human adenovirus in nasal polyps and turbinate mucosa. Epstein-Barr病毒、人乳头瘤病毒、人巨细胞病毒和人腺病毒在鼻息肉和鼻甲黏膜中的交叉评价。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2024-12-30 DOI: 10.1080/00016489.2024.2445025

Alexandra Schindele, Anna Holm, Sofie Kraft, Karin Nylander, Annika Allard, Katarina Olofsson

{"title":"Cross-evaluating Epstein-Barr virus, human papilloma virus, human cytomegalovirus and human adenovirus in nasal polyps and turbinate mucosa.","authors":"Alexandra Schindele, Anna Holm, Sofie Kraft, Karin Nylander, Annika Allard, Katarina Olofsson","doi":"10.1080/00016489.2024.2445025","DOIUrl":"10.1080/00016489.2024.2445025","url":null,"abstract":"Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease in which inflammatory responses to exogenic stressors, such as viral infections, has been recognised. The role of viruses in CRSwNP pathogenesis is unclear.Aims/objectives: We aimed to characterise Epstein-Barr virus (EBV), human papillomavirus (HPV), human cytomegalovirus (HCMV), and human adenovirus (HAdV) in nasal polyps and adjacent paired healthy turbinate mucosa.Materials and methods: We used real-time PCR for EBV, HCMV, and HAdV DNA detection, combined PCR/microarrays for HPV detection and genotyping, in samples from 45 patients with CRSwNP. Additionally, we used EBER in situ hybridisation for EBV detection.Results: EBV detection with EBER-ISH was significantly higher in polyps (36%) versus turbinate mucosa (12%). None of the viral comparisons with PCR between polyps and turbinate mucosa for EBV-, HCMV- or HAdV-DNA showed statistically significant differences. All samples were HPV negative.Conclusions and significance: We report higher expression of EBV in nasal polyps (36%) than in adjacent healthy turbinate mucosa (12%), using a valid method; EBER-ISH in 45 patients with CRSwNP. EBV might be a possible stressor that can trigger polypoid inflammation.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":"145 2","pages":"164-167"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Transforming Growth Factor-β1 in the nasal polyp tissue of chronic rhinosinusitis: a comprehensive analysis. 慢性鼻窦炎鼻息肉组织中转化生长因子-β1的鉴定：综合分析

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2025-01-29 DOI: 10.1080/00016489.2025.2449709

Iriana Maharani, Loeki Enggar Fitri, Susanthy Djajalaksana, Edi Handoko

{"title":"Identification of Transforming Growth Factor-β1 in the nasal polyp tissue of chronic rhinosinusitis: a comprehensive analysis.","authors":"Iriana Maharani, Loeki Enggar Fitri, Susanthy Djajalaksana, Edi Handoko","doi":"10.1080/00016489.2025.2449709","DOIUrl":"10.1080/00016489.2025.2449709","url":null,"abstract":"Background: Chronic Transforming Growth Factor Beta 1 (TGF-β1) plays a critical role in tissue remodelling and immunological modulation, which may contribute to the severity and recurrence of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Despite extensive research on CRSwNP, the exact role and pathological significance of TGF-β1 in CRSwNP remain poorly understood due to inconsistencies in study methodologies and findings.Aims/objectives: To resolve discrepancies in the literature, this systematic review compares the levels of TGF-β1 in CRSwNP tissue to controls and Chronic Rhinosinusitis without Nasal Polyps (CRSsNP).Material and methods: A comprehensive literature search was conducted across databases such as PubMed, ScienceDirect, and Cochrane Library. Studies assessing TGF-β1 levels in the tissue through various methods were systematically reviewed. Data were extracted on TGF-β1 levels, methodological approaches, and clinical correlations.Results: The review indicates that TGF-β1 levels were highly variable in controls, elevated in CRSsNP, and broadly ranged in CRSwNP with generally lower levels compared to CRSsNP, placing controls between CRSwNP and CRSsNP.Conclusions and significance: Elevated TGF-β1 in CRSsNP points to its significant role in fibrosis and tissue remodeling, which could inform targeted therapeutic approaches and improve management strategies for chronic rhinosinusitis.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"168-175"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic efficacy of canalith reposition maneuver according to the determination method of lesion side in patients with persistent geotropic direction-changing positional nystagmus. 根据病变侧边确定方法的管体复位手法治疗持续性地向性变向体位性眼球震颤的疗效观察。

IF 1.2 4区医学

Acta Oto-Laryngologica Pub Date : 2025-02-01 Epub Date: 2025-01-13 DOI: 10.1080/00016489.2024.2449252

Seok Min Hong, Sang Hoon Kim, Jae Yong Byun, Seung Geun Yeo

{"title":"Therapeutic efficacy of canalith reposition maneuver according to the determination method of lesion side in patients with persistent geotropic direction-changing positional nystagmus.","authors":"Seok Min Hong, Sang Hoon Kim, Jae Yong Byun, Seung Geun Yeo","doi":"10.1080/00016489.2024.2449252","DOIUrl":"10.1080/00016489.2024.2449252","url":null,"abstract":"Background: The Canalith Repositioning Maneuver (CRM) is often ineffective for persistent geotropic direction-changing positional nystagmus (DCPN). In these cases, determining the lesion side can be challenging, as the null plane side and the side with stronger nystagmus on the roll test are frequently opposite.Objectives: This study investigates whether the low therapeutic efficacy of CRM in persistent DCPN could be attributed to incorrect determination of the lesion side.Material and methods: This prospective randomized trial involved two groups of patients with persistent geotropic DCPN, categorized based on the method used to determine the lesion side: the null plane side and the side with stronger nystagmus on the head roll test. We assessed the therapeutic efficacy of CRM on the null plane side (null plane group) and the side with stronger nystagmus on the head roll test (stronger nystagmus group).Results: Both groups showed minimal or no immediate therapeutic effect of CRM, with a low short-term effect observed in both as well. No significant differences were found in the immediate and short-term therapeutic effects of CRM between the two groups.Conclusions and significance: The limited therapeutic effect of CRM in persistent geotropic DCPN does not appear to result from incorrect determination of the lesion side.","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"140-143"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0