Acta Oto-Laryngologica最新文献

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3D ultrasound in evaluating resection margins during salivary gland tumour surgery. 唾液腺肿瘤手术切除边缘的三维超声评价。
IF 1.3 4区 医学
Acta Oto-Laryngologica Pub Date : 2026-08-01 Epub Date: 2026-04-08 DOI: 10.1080/00016489.2026.2649325
Mads Bøgh, Benedicte Parm Ulhøi, Nelson Fuentes Martinez, Kasper Basse Reinholdt, Tejs Ehlers Klug, Søren Dürr Gade, Arunas Pikelis, René Thunberg Svendsen, Tina K Agander, Marcus Wessman, Fatemeh Makouei, Tobias Todsen, Thomas Kjærgaard
{"title":"3D ultrasound in evaluating resection margins during salivary gland tumour surgery.","authors":"Mads Bøgh, Benedicte Parm Ulhøi, Nelson Fuentes Martinez, Kasper Basse Reinholdt, Tejs Ehlers Klug, Søren Dürr Gade, Arunas Pikelis, René Thunberg Svendsen, Tina K Agander, Marcus Wessman, Fatemeh Makouei, Tobias Todsen, Thomas Kjærgaard","doi":"10.1080/00016489.2026.2649325","DOIUrl":"10.1080/00016489.2026.2649325","url":null,"abstract":"<p><strong>Background: </strong>Achieving clear margins in salivary gland tumour surgery is challenging. An accurate intraoperative method for specimen margin assessment is needed.</p><p><strong>Aims/objectives: </strong>To evaluate the accuracy of three-dimensional (3D) ultrasound (US) for intraoperative margin assessment in salivary gland tumour surgery.</p><p><strong>Materials and methods: </strong>Patients undergoing surgery for pleomorphic adenomas or suspected malignant tumours of the parotid or submandibular gland were prospectively included. After tumour resection, 3D US imaging of the specimen was performed using a novel setup. Tumour measurements and resection margins were assessed and compared with histopathology. Margin status was categorised using a predefined 1-mm cut-off.</p><p><strong>Results: </strong>Twenty-eight patients were included. Margin status was correctly classified by 3D US in 26 cases (93%). Using a 1-mm cut-off, sensitivity was 96%, specificity 75%, positive predictive value (PPV) 96%, and negative predictive value (NPV) 75%. For images corresponding to histopathological slices, sensitivity was 96%, specificity 92%, PPV 98%, and NPV 85%. Tumour area and smallest margin per slice correlated strongly with histopathology (<i>r</i> = 0.99 and <i>r</i> = 0.95, respectively).</p><p><strong>Conclusions: </strong>3D US enables accurate intraoperative classification of margin status and provides tumour and margin measurements in close agreement with histopathology.</p><p><strong>Significance: </strong>This low-cost, accessible technique may support real-time decision-making, improve surgical radicality, and reduce the need for re-interventions.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"972-980"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of auditory and cochlear functions in patients with rheumatoid arthritis. 类风湿关节炎患者听觉和耳蜗功能的评估。
IF 1.3 4区 医学
Acta Oto-Laryngologica Pub Date : 2026-08-01 Epub Date: 2026-03-26 DOI: 10.1080/00016489.2026.2644359
Taha Yasin Yildiz, Mehmet Akif Dündar
{"title":"Evaluation of auditory and cochlear functions in patients with rheumatoid arthritis.","authors":"Taha Yasin Yildiz, Mehmet Akif Dündar","doi":"10.1080/00016489.2026.2644359","DOIUrl":"10.1080/00016489.2026.2644359","url":null,"abstract":"<p><strong>Background: </strong>Both sensorineural and conductive hearing loss have been reported in patients with rheumatoid arthritis (RA), with sensorineural hearing loss (SNHL) being more common (24-60%).</p><p><strong>Aims/objectives: </strong>This study aimed to evaluate auditory and cochlear functions in patients with seropositive RA.</p><p><strong>Material and methods: </strong>Forty seropositive RA patients and forty healthy volunteers were included. All participants underwent a complete ear, nose, and throat examination followed by pure tone audiometry, tympanometry, contralateral and ipsilateral acoustic reflex testing, and transient evoked otoacoustic emission (TEOAE) testing. Audiological evaluation included air and bone conduction thresholds, speech reception threshold, speech discrimination scores, uncomfortable loudness levels, and most comfortable loudness levels.</p><p><strong>Results: </strong>Mild high-frequency sensorineural threshold elevations were observed in 14 patients (27 ears, 33.75%), predominantly affecting frequencies of 4-6 kHz. Although statistically significant differences were observed across frequencies, threshold elevations were predominantly mild and mainly involved high frequencies. Two RA patients (5%) showed bilateral mixed-type hearing loss. In the control group, two participants (5%) had bilateral sensorineural threshold elevations.</p><p><strong>Conclusion and significance: </strong>The findings suggest subtle and predominantly high-frequency auditory and cochlear changes in patients with rheumatoid arthritis. Routine audiological evaluation and follow-up may be useful for early detection of subclinical auditory involvement.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"925-932"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A dilated mastoid emissary vein as a potential cause of pulsatile tinnitus. 扩张性乳突传递静脉作为搏动性耳鸣的潜在原因。
IF 1.3 4区 医学
Acta Oto-Laryngologica Pub Date : 2026-08-01 Epub Date: 2026-05-10 DOI: 10.1080/00016489.2026.2659350
Min Young Kwak, Hye Ah Joo
{"title":"A dilated mastoid emissary vein as a potential cause of pulsatile tinnitus.","authors":"Min Young Kwak, Hye Ah Joo","doi":"10.1080/00016489.2026.2659350","DOIUrl":"10.1080/00016489.2026.2659350","url":null,"abstract":"<p><strong>Background: </strong>Pulsatile tinnitus (PT) is commonly attributed to vascular etiologies; however, up to half of cases remain idiopathic.</p><p><strong>Objectives: </strong>To investigate the association between the mastoid emissary vein (MEV) and PT and to identify MEV-related factors contributing to PT.</p><p><strong>Materials and methods: </strong>This retrospective study included 119 adults (237 ears; PT, 46 ears; non-PT, 191 ears) who underwent temporal bone computed tomography between January 2019 and July 2025. MEV presence, dilation, and morphological features were analyzed.</p><p><strong>Results: </strong>MEV was identified in 73.9% of PT ears and 61.3% of non-PT ears, without a significant difference. However, dilated MEV was significantly more common in the PT group (56.5% vs. 29.3%, OR = 3.13, <i>p</i> < 0.001). Among 151 ears with MEV, PT ears showed a higher prevalence of dilation (76.5% vs. 47.9%, OR = 3.54, <i>p</i> = 0.003). Mean MEV orifice diameter was significantly larger in the PT group on both axial and coronal images. MEV presence was also associated with concomitant venous abnormalities (OR = 2.05, <i>p</i> = 0.035).</p><p><strong>Conclusions and significance: </strong>MEV dilation is strongly associated with PT and frequently accompanied by venous abnormalities. Careful radiologic evaluation of MEV may help identify potential vascular contributors in patients with idiopathic PT.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1019-1026"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic-assisted versus conventional closed septorhinoplasty: a comparative study of functional, aesthetic, and postoperative outcomes. 内镜辅助与常规闭合性鼻中隔成形术:功能、美学和术后结果的比较研究。
IF 1.3 4区 医学
Acta Oto-Laryngologica Pub Date : 2026-08-01 Epub Date: 2026-04-29 DOI: 10.1080/00016489.2026.2661098
Saad Elzayat, Youssef Zaki, Ahmed Samy Abdel-Hamid
{"title":"Endoscopic-assisted versus conventional closed septorhinoplasty: a comparative study of functional, aesthetic, and postoperative outcomes.","authors":"Saad Elzayat, Youssef Zaki, Ahmed Samy Abdel-Hamid","doi":"10.1080/00016489.2026.2661098","DOIUrl":"10.1080/00016489.2026.2661098","url":null,"abstract":"<p><strong>Background: </strong>Nasal septal deviation is a common cause of nasal obstruction, and septorhinoplasty addresses both functional and aesthetic concerns. The role of endoscopic assistance in closed septorhinoplasty remains incompletely characterized.</p><p><strong>Objectives: </strong>To compare conventional closed and endoscopic-assisted septorhinoplasty regarding functional and aesthetic outcomes, postoperative morbidity, and operative time.</p><p><strong>Materials and methods: </strong>This prospective, randomized, single-blinded clinical trial included 50 patients randomized to conventional closed (group A) or endoscopic-assisted septorhinoplasty (group B). Outcomes included Nasal Obstruction Symptom Evaluation (NOSE) scores, FACE-Q Rhinoplasty Module, operative time, and postoperative morbidity (edema, ecchymosis, pain).</p><p><strong>Results: </strong>Operative time was longer in group B (116.68 ± 7.02 vs. 90.96 ± 7.07 min; <i>p</i> < 0.001). Group B showed significantly greater NOSE score improvement at 1 and 6 months (<i>p</i> < 0.001). Aesthetic satisfaction was higher in group B at 1 month (<i>p</i> < 0.001) but comparable at 6 months. Postoperative edema, ecchymosis, and day-7 pain scores were significantly lower in group B (<i>p</i> < 0.05).</p><p><strong>Conclusions and significance: </strong>Endoscopic-assisted septorhinoplasty offers superior early functional outcomes and reduced postoperative morbidity despite longer operative time, with comparable long-term aesthetic results. These findings support endoscopic assistance as a valuable adjunct for enhancing surgical precision and early recovery in septorhinoplasty.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1044-1054"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the relationship between structural damage and hearing impairment based on the whole ear model. 基于全耳模型的结构损伤与听力损害关系研究。
IF 1.3 4区 医学
Acta Oto-Laryngologica Pub Date : 2026-08-01 Epub Date: 2026-03-23 DOI: 10.1080/00016489.2026.2645388
Wenjuan Yao, Jiakun Wang, Maoli Duan, Junhua Ye
{"title":"Investigation of the relationship between structural damage and hearing impairment based on the whole ear model.","authors":"Wenjuan Yao, Jiakun Wang, Maoli Duan, Junhua Ye","doi":"10.1080/00016489.2026.2645388","DOIUrl":"10.1080/00016489.2026.2645388","url":null,"abstract":"<p><strong>Background: </strong>With the existing experimental techniques, it is unable to measure the overall structural vibration of the human ear, which is difficult to reflect the relationship between hearing and ear structures.</p><p><strong>Aims/objectives: </strong>The overall biomechanical behaviour of the whole ear structure during sound perception is described.</p><p><strong>Methods: </strong>Based on CT scanning data and knowledge of ear physiology, a 3D whole ear numerical model was developed that conforms to the actual physiological environment of the human body.</p><p><strong>Results: </strong>The outer ear canal (EC) has an amplifying effect on sound conduction. The middle-lower part of tympanic membrane (TM) is susceptible to damage, which is mainly reflected in the high-tendency of clinically TM perforation phenomenon. Similarly, TM's damage or hypoplasia is also common. Peak amplitude occurs at the center of one-side of the oval window membrane (OWM) and the center of the round window membrane (RWM), respectively, and these areas are prone to disruption and more severely may evolve into perilymph fistulas. The BM's amplitude changes longitudinally along the cochlear helix as frequency increases.</p><p><strong>Conclusions and significance: </strong>This model reflects the impact of localized structural damage on hearing under the coordinated working of the whole ear (outer, middle and inner ears).</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"933-945"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the Impact of Intraoperative Magnetic Resonance Imaging on the Resection of Juvenile Nasopharyngeal AngiofibromaEvaluating the impact of intraoperative MRI on the resection of juvenile nasopharyngeal angiofibroma. 评价术中磁共振成像对青少年鼻咽血管纤维瘤切除术的影响评价术中MRI对青少年鼻咽血管纤维瘤切除术的影响。
IF 1.3 4区 医学
Acta Oto-Laryngologica Pub Date : 2026-08-01 Epub Date: 2026-05-04 DOI: 10.1080/00016489.2026.2658629
Mucahit Yalcin, Gokberk Erol, Alperen Sozer, Mehmet Ekrem Zorlu, Emetullah Cindil, Nil Tokgoz, Emrah Celtikci, Muammer Melih Sahin
{"title":"Evaluating the Impact of Intraoperative Magnetic Resonance Imaging on the Resection of Juvenile Nasopharyngeal AngiofibromaEvaluating the impact of intraoperative MRI on the resection of juvenile nasopharyngeal angiofibroma.","authors":"Mucahit Yalcin, Gokberk Erol, Alperen Sozer, Mehmet Ekrem Zorlu, Emetullah Cindil, Nil Tokgoz, Emrah Celtikci, Muammer Melih Sahin","doi":"10.1080/00016489.2026.2658629","DOIUrl":"10.1080/00016489.2026.2658629","url":null,"abstract":"<p><strong>Background: </strong>Complete resection is essential in the management of juvenile nasopharyngeal angiofibroma (JNA), yet residual disease remains a major cause of recurrence, particularly in advanced cases. Intraoperative MRI (IO-MRI) may support intraoperative decision-making, but its clinical utility in JNA surgery remains unclear.</p><p><strong>Aims/objectives: </strong>To evaluate the selective role of intraoperative MRI (IO-MRI) in intraoperative decision-making during endoscopic resection of JNA.</p><p><strong>Material and methods: </strong>Nine patients who underwent endoscopic endonasal resection of JNA with IO-MRI assistance were retrospectively reviewed. IO-MRI findings, intraoperative management changes, and follow-up outcomes were evaluated.</p><p><strong>Results: </strong>IO-MRI detected no residual tumor in seven patients (77.7%). In one case, residual disease identified on IO-MRI prompted additional resection during the same operation. In another case, a residual tumor involving critical neurovascular structures was detected, and further resection was avoided. No recurrence was observed in eight patients during follow-up, and no IO-MRI-related morbidity occurred.</p><p><strong>Conclusions: </strong>IO-MRI may serve as a valuable adjunct in JNA surgery by supporting intraoperative decisions to either continue or safely limit resection. Its use appears most beneficial in anatomically complex or advanced-stage tumors.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1004-1012"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploratory analysis of stromal and peritumoural tumour-infiltrating lymphocytes (tils) in malignant parotid gland tumours: associations with clinicopathological factors and survival. 恶性腮腺肿瘤间质和瘤周浸润淋巴细胞(til)的探索性分析:与临床病理因素和生存的关系。
IF 1.3 4区 医学
Acta Oto-Laryngologica Pub Date : 2026-08-01 Epub Date: 2026-03-26 DOI: 10.1080/00016489.2026.2646285
Selçuk Erol, Ayça Arslan, Nazan Bozdoğan, I Emre Kiliç
{"title":"Exploratory analysis of stromal and peritumoural tumour-infiltrating lymphocytes (tils) in malignant parotid gland tumours: associations with clinicopathological factors and survival.","authors":"Selçuk Erol, Ayça Arslan, Nazan Bozdoğan, I Emre Kiliç","doi":"10.1080/00016489.2026.2646285","DOIUrl":"10.1080/00016489.2026.2646285","url":null,"abstract":"<p><strong>Background: </strong>The tumour immune microenvironment may influence prognosis in many cancers, but its significance in malignant parotid gland tumours is not well defined.</p><p><strong>Aims/objectives: </strong>To evaluate whether stromal and peritumoural tumour-infiltrating lymphocyte (TIL) density is associated with clinicopathological features and overall survival in malignant parotid gland tumours.</p><p><strong>Material and methods: </strong>Thirty patients who underwent surgery for malignant parotid gland tumours (2013-2024) were retrospectively analysed. Stromal and peritumoural TIL densities were assessed on haematoxylin-eosin-stained sections and recorded as percentages. For exploratory survival analysis, TIL density was grouped as low-intermediate (0-40%) or high (50-90%). Overall survival was evaluated using Kaplan-Meier analysis and the log-rank test.</p><p><strong>Results: </strong>Mean age was 54.9 ± 16.1 years. Higher peritumoural TIL density was associated with longer overall survival (log-rank <i>p</i> = 0.045). No significant relationships were found between TIL density and other clinicopathological variables.</p><p><strong>Conclusions and significance: </strong>These exploratory findings suggest that increased peritumoural TIL density may indicate better survival in malignant parotid gland tumours. TIL assessment could provide prognostic information, but larger prospective studies are needed.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"953-959"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical efficacy and prognostic factors of endoscopic surgery for chronic suppurative otitis media: a retrospective cohort study. 内镜手术治疗慢性化脓性中耳炎的临床疗效及预后因素:一项回顾性队列研究。
IF 1.3 4区 医学
Acta Oto-Laryngologica Pub Date : 2026-08-01 Epub Date: 2026-03-13 DOI: 10.1080/00016489.2026.2641824
Hao He, A Heng Wang, Yu Wu, Zhengping Xia
{"title":"Clinical efficacy and prognostic factors of endoscopic surgery for chronic suppurative otitis media: a retrospective cohort study.","authors":"Hao He, A Heng Wang, Yu Wu, Zhengping Xia","doi":"10.1080/00016489.2026.2641824","DOIUrl":"10.1080/00016489.2026.2641824","url":null,"abstract":"<p><strong>Background: </strong>Chronic suppurative otitis media (CSOM) is a significant global health concern, leading to persistent ear discharge and hearing loss.</p><p><strong>Aims/objectives: </strong>This study aimed to evaluate the clinical efficacy and safety of EES for CSOM and to identify independent prognostic factors influencing surgical success.</p><p><strong>Materials and methods: </strong>In this single-center retrospective cohort study, 180 patients undergoing EES for CSOM between 2022 and 2024 were enrolled. Data on demographics, clinical profiles, and surgical details were collected. Primary outcomes included dry ear rate, pure-tone average (PTA) improvement, and complications at 6 months post-surgery.</p><p><strong>Results: </strong>The 6-month dry ear rate was 91.1%. Mean PTA improved significantly by 24.8 ± 7.2 dB. The complication rate was 3.9%. Multivariate analysis identified cholesteatoma (HR = 3.24, 95% CI: 1.85-5.68, <i>p</i> < 0.001), disease duration >5 years (HR = 2.52, 95% CI: 1.45-4.38, <i>p</i> = 0.001), and preoperative PTA >50 dB (HR = 2.89, 95% CI: 1.65-5.06, <i>p</i> < 0.001) as independent risk factors for failure. Subgroup analyses confirmed the consistency of these factors.</p><p><strong>Conclusions and significance: </strong>Endoscopic ear surgery is an effective and safe treatment for CSOM in the mid-term (6-month) follow-up. Cholesteatoma, prolonged disease duration, and severe preoperative hearing loss are robust predictors of poorer outcomes.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"917-924"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Refusal of surgery in patients with laryngeal or hypopharyngeal squamous cell carcinoma. 喉部或下咽鳞状细胞癌患者拒绝手术。
IF 1.3 4区 医学
Acta Oto-Laryngologica Pub Date : 2026-08-01 Epub Date: 2026-04-20 DOI: 10.1080/00016489.2026.2653173
Yoshihito Kubo, Ichiro Tojima, Kai Yamazaki, Kento Kawakita, Tatsuji Nishiguchi, Tomoyuki Sudo, Koji Matsumoto, Shigehiro Owaki, Yukinori Takenaka
{"title":"Refusal of surgery in patients with laryngeal or hypopharyngeal squamous cell carcinoma.","authors":"Yoshihito Kubo, Ichiro Tojima, Kai Yamazaki, Kento Kawakita, Tatsuji Nishiguchi, Tomoyuki Sudo, Koji Matsumoto, Shigehiro Owaki, Yukinori Takenaka","doi":"10.1080/00016489.2026.2653173","DOIUrl":"10.1080/00016489.2026.2653173","url":null,"abstract":"<p><strong>Background: </strong>Patients with laryngeal and hypopharyngeal cancers may refuse recommended surgery owing to concerns about voice loss.</p><p><strong>Objectives: </strong>To investigate the factors associated with surgery refusal and the survival outcomes of patients who refused surgery.</p><p><strong>Patients and methods: </strong>We obtained data from 24,340 surgery and 1500 refusal cases using the Surveillance, Epidemiology, and End Results database. Overall survival (OS) rates were estimated using the Kaplan-Meier method. Odds ratios for surgery refusal and hazard ratios (HRs) for death were calculated using logistic regression and Cox proportional hazard models.</p><p><strong>Results: </strong>Older age, year of diagnosis, advanced disease and marital status were associated with surgery refusal. The five-year OS rate was significantly lower in the refusal group than in the surgery group (27.3% vs. 55.8%, respectively) (<i>p</i> < 0.001). Within the refusal group, patients who refused both surgery and radiation therapy (RT) had a five-year survival rate of 8.9%, whereas those who refused surgery but received RT showed a five-year OS rate of 36.3%. Administration of RT and chemotherapy were independent prognostic factors for OS (HR 0.41 (95%CI 0.35-0.48) and 0.80 (95%CI 0.69-0.91), respectively).</p><p><strong>Conclusions: </strong>Although non-surgical treatment remains an alternative option, surgery refusal is associated with poor prognosis.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"981-987"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"When patients see what the surgeon sees": 3D imaging creates new understanding in preoperative counseling for endoscopic sinus surgery. “当病人看到外科医生所看到的”:3D成像为内窥镜鼻窦手术的术前咨询提供了新的认识。
IF 1.3 4区 医学
Acta Oto-Laryngologica Pub Date : 2026-08-01 Epub Date: 2026-04-20 DOI: 10.1080/00016489.2026.2656278
Jonas Kornmann, Philipp Lorenz, Paul Bonik, Annette Affolter, Lena Huber, Lena Zaubitzer, Nicole Rotter, Claudia Scherl
{"title":"\"When patients see what the surgeon sees\": 3D imaging creates new understanding in preoperative counseling for endoscopic sinus surgery.","authors":"Jonas Kornmann, Philipp Lorenz, Paul Bonik, Annette Affolter, Lena Huber, Lena Zaubitzer, Nicole Rotter, Claudia Scherl","doi":"10.1080/00016489.2026.2656278","DOIUrl":"10.1080/00016489.2026.2656278","url":null,"abstract":"<p><strong>Background: </strong>In functional endoscopic sinus surgery, the intricate anatomy and the use of minimally invasive endoscopic techniques may hinder comprehensive patient understanding in the informed consent process.</p><p><strong>Aims/objectives: </strong>Evaluation of the impact of personalized 3D CT computed tomography (CT) imaging supplementing informed consent in sinus surgery.</p><p><strong>Material and methods: </strong>In this prospective randomized study, patients scheduled for paranasal sinus surgery were allocated to standard informed consent using two-dimensional (2D) CT imaging or to counseling supplemented with individualized three-dimensional (3D) CT reconstructions. All patients received a questionnaire prior- and postsurgery to assess disease comprehension, perception of risks and benefits, and satisfaction with the informed consent process.</p><p><strong>Results: </strong>Twenty-two patients were included, with equal distribution between groups. The 3D group demonstrated significantly greater understanding of expected recovery and recurrence (<i>p</i> = 0.03) and improved knowledge transfer (<i>p</i> = 0.04). Postoperatively, the 3D group reported significantly higher understanding scores (4.50 vs. 2.73). The composite outcome-encompassing disease understanding, surgical comprehension, and overall satisfaction-was superior in the 3D group (16.00 vs. 11.64; <i>p</i> < 0.01).</p><p><strong>Conclusions and significance: </strong>Patient-specific 3D CT reconstructions may enhance informed consent in sinus surgery, improving comprehension, shared decision-making, and satisfaction with preoperative counseling.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"988-996"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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