Quantitative and qualitative evaluation of anti-pneumococcal specific antibodies in children with recurrent acute otitis media.

IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY
Masamitsu Kono, Eisuke Kuroda, Takuro Iyo, Nafisa Khamis Umar, Ayumi Hirayama, Saori Takeda, Daichi Murakami, Shigeto Hamaguchi, Muneki Hotomi
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引用次数: 0

Abstract

Background: Pneumococcal conjugated vaccine (PCV) has contributed to a dramatic reduction in invasive pneumococcal diseases. However, its impact upon nasopharyngeal carriage and upper respiratory tract infections is unclear.

Aims/objectives: This study was aimed to evaluate the humoral immunity against Streptococcus pneumoniae in children with recurrent acute otitis media (rAOM) in the post PCV era.

Materials and methods: We evaluated the humoral immunity against eight representative serotypes included in PCV13 (3, 6 A, 6B, 9 V, 14, 18 C, 19 F, and 23 F) among children with rAOM.

Results: Serum total immunoglobulin levels were typically within the normal range, but there was a decrease in IgG2 in >20% of cases. Serotype-specific antibody titers were not significantly different for any serotype in the rAOM group compared with the healthy controls, except for serotype 3. Conversely, the ability of serotype-specific antibodies to induce opsonophagocytic killing was increased in the rAOM group for three serotypes (6 A, 6B, and 14). There was a positive correlation between the titer of antibodies and the opsonophagocytic killing activity in five serotypes (6 A, 6B, 9 V, 19 F, and 23 F).

Conclusion and significance: Quantitative and qualitative evaluation of serotype-specific antibodies would be an important method for evaluating humoral immunity in children with rAOM.

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来源期刊
Acta Oto-Laryngologica
Acta Oto-Laryngologica 医学-耳鼻喉科学
CiteScore
2.50
自引率
0.00%
发文量
99
审稿时长
3-6 weeks
期刊介绍: Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.
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