{"title":"Quantitative and qualitative evaluation of anti-pneumococcal specific antibodies in children with recurrent acute otitis media.","authors":"Masamitsu Kono, Eisuke Kuroda, Takuro Iyo, Nafisa Khamis Umar, Ayumi Hirayama, Saori Takeda, Daichi Murakami, Shigeto Hamaguchi, Muneki Hotomi","doi":"10.1080/00016489.2025.2468397","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pneumococcal conjugated vaccine (PCV) has contributed to a dramatic reduction in invasive pneumococcal diseases. However, its impact upon nasopharyngeal carriage and upper respiratory tract infections is unclear.</p><p><strong>Aims/objectives: </strong>This study was aimed to evaluate the humoral immunity against <i>Streptococcus pneumoniae</i> in children with recurrent acute otitis media (rAOM) in the post PCV era.</p><p><strong>Materials and methods: </strong>We evaluated the humoral immunity against eight representative serotypes included in PCV13 (3, 6 A, 6B, 9 V, 14, 18 C, 19 F, and 23 F) among children with rAOM.</p><p><strong>Results: </strong>Serum total immunoglobulin levels were typically within the normal range, but there was a decrease in IgG2 in >20% of cases. Serotype-specific antibody titers were not significantly different for any serotype in the rAOM group compared with the healthy controls, except for serotype 3. Conversely, the ability of serotype-specific antibodies to induce opsonophagocytic killing was increased in the rAOM group for three serotypes (6 A, 6B, and 14). There was a positive correlation between the titer of antibodies and the opsonophagocytic killing activity in five serotypes (6 A, 6B, 9 V, 19 F, and 23 F).</p><p><strong>Conclusion and significance: </strong>Quantitative and qualitative evaluation of serotype-specific antibodies would be an important method for evaluating humoral immunity in children with rAOM.</p>","PeriodicalId":6880,"journal":{"name":"Acta Oto-Laryngologica","volume":" ","pages":"1-8"},"PeriodicalIF":1.2000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Oto-Laryngologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00016489.2025.2468397","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Pneumococcal conjugated vaccine (PCV) has contributed to a dramatic reduction in invasive pneumococcal diseases. However, its impact upon nasopharyngeal carriage and upper respiratory tract infections is unclear.
Aims/objectives: This study was aimed to evaluate the humoral immunity against Streptococcus pneumoniae in children with recurrent acute otitis media (rAOM) in the post PCV era.
Materials and methods: We evaluated the humoral immunity against eight representative serotypes included in PCV13 (3, 6 A, 6B, 9 V, 14, 18 C, 19 F, and 23 F) among children with rAOM.
Results: Serum total immunoglobulin levels were typically within the normal range, but there was a decrease in IgG2 in >20% of cases. Serotype-specific antibody titers were not significantly different for any serotype in the rAOM group compared with the healthy controls, except for serotype 3. Conversely, the ability of serotype-specific antibodies to induce opsonophagocytic killing was increased in the rAOM group for three serotypes (6 A, 6B, and 14). There was a positive correlation between the titer of antibodies and the opsonophagocytic killing activity in five serotypes (6 A, 6B, 9 V, 19 F, and 23 F).
Conclusion and significance: Quantitative and qualitative evaluation of serotype-specific antibodies would be an important method for evaluating humoral immunity in children with rAOM.
期刊介绍:
Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.