The influence of saliva pepsin concentration on subjective severity of seasonal allergic rhinitis.

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

Acta Oto-Laryngologica Pub Date : 2025-04-01 Epub Date: 2025-02-11 DOI:10.1080/00016489.2025.2460610

Haijing Sui, Zhu Luo, Xuehan Zhang, Junbo Zhang, Zhen Zhen, Ting Ding

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引用次数: 0

Abstract

Backgrounds: Some studies believe that there is a correlation between larygopharyngeal reflux disease (LPRD) and allergic rhinitis (AR). Salivary pepsin concentration (SPC) test is a gradually accepted objective examination method for LPRD in recent years.

Objectives: To investigate the impact of coexisting LPRD on subjective severity of seasonal AR and the potential role of pepsin.

Material and methods: Adult patients with seasonal AR were prospectively enrolled. Subjective severity of AR was assessed using the Total Nasal Symptom Score (TNSS) and visual analog scale (VAS). Potential LPRD was assessed using the Reflux Symptom Index (RSI) and SPC measurements.

Results: No significant correlation was found between the RSI value and the TNSS and VAS values (both p > .05). In contrast, the SPC value was found to be significantly associated with both of TNSS and VAS values (p < .05). Among the symptoms included in the TNSS, the SPC value was significantly and positively associated with nasal congestion and runny nose (both p < .05), but not with sneezing and nasal itching (both p > .05).

Conclusions and significance: Coexisting LPRD may aggravates seasonal AR symptoms. SPC could be used to examine whether AR patients have combined LPRD and to determine the necessity of anti-reflux treatment.

查看原文本刊更多论文

唾液胃蛋白酶浓度对季节性变应性鼻炎主观严重程度的影响。

背景：有研究认为喉部反流病（LPRD）与变应性鼻炎（AR）存在相关性。唾液胃蛋白酶浓度（SPC）检测是近年来逐渐被接受的一种检测LPRD的客观方法。目的：探讨并发LPRD对季节性AR主观严重程度的影响及胃蛋白酶的潜在作用。材料和方法：前瞻性纳入季节性AR的成年患者。采用鼻症状总评分（TNSS）和视觉模拟量表（VAS）评估AR的主观严重程度。使用反流症状指数（RSI）和SPC测量评估潜在LPRD。结果：RSI值与TNSS、VAS值无显著相关性（p < 0.05）。相比之下，SPC值与TNSS和VAS值显著相关（p p p >.05）。结论及意义：合并LPRD可加重季节性AR症状。SPC可用于检查AR患者是否合并LPRD，并确定抗反流治疗的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Oto-Laryngologica 医学-耳鼻喉科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.