Examining the causal relationship between hypertension and benign paroxysmal vertigo: a univariate and multivariate Mendelian randomization study.

IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY
Luyao Wang, Feilun Cui, Xiangping Chen, Qing Zhang, Jun Yang, Shuna Li
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引用次数: 0

Abstract

Background: Patients with benign paroxysmal positional vertigo (BPPV) may be at increased risk for hypertension.

Objectives: To examine the causal relationship between hypertensive disorders and benign paroxysmal vertigo (BPV).

Materials and methods: A bidirectional two-sample Mendelian randomization (MR) study was conducted to assess the causal relationship between hypertension and BPV. Summary statistics for BPV and hypertension were obtained from the FinnGen biobank to support the primary MR analysis. Five complementary methods - inverse variance weighted, weighted median, MR-Egger, simple mode, and weighted mode - were applied to obtain MR estimates. Furthermore, a multivariable MR (MVMR) analysis was conducted to examine whether hypertension independently influences BPV.

Results: The MR analysis indicated a significant causal effect of hypertension on BPV, with an odds ratio (OR) of 1.11 (95% CI: 1.02-1.22, p = .019), indicating an increased risk of BPV associated with hypertension. MVMR analysis further indicated that the causal effect of hypertension on BPV remained significant even after adjusting for menopausal disorders and ischemic stroke (OR: 1.108, 95% CI: 1.003-1.225, p = .043).

Conclusions and significance: This MR study provided evidence supporting a causal effect of hypertension on BPV.

检查高血压和良性阵发性眩晕之间的因果关系:单变量和多变量孟德尔随机化研究。
背景:良性阵发性体位性眩晕(BPPV)患者患高血压的风险可能增加。目的:探讨高血压疾病与良性阵发性眩晕(BPV)的因果关系。材料和方法:通过双向双样本孟德尔随机化(MR)研究来评估高血压和BPV之间的因果关系。BPV和高血压的汇总统计数据来自FinnGen生物银行,以支持主要的MR分析。采用方差反加权、加权中位数、MR- egger、简单模式和加权模式五种互补方法获得MR估计。此外,进行了多变量MR (MVMR)分析,以检查高血压是否独立影响BPV。结果:MR分析显示高血压与BPV有显著的因果关系,比值比(OR)为1.11 (95% CI: 1.02-1.22, p = 0.019),表明高血压与BPV的风险增加有关。MVMR分析进一步表明,即使在调整更年期失调和缺血性卒中后,高血压对BPV的因果影响仍然显著(OR: 1.108, 95% CI: 1.003-1.225, p = 0.043)。结论和意义:这项MR研究为高血压对BPV的因果效应提供了证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Oto-Laryngologica
Acta Oto-Laryngologica 医学-耳鼻喉科学
CiteScore
2.50
自引率
0.00%
发文量
99
审稿时长
3-6 weeks
期刊介绍: Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.
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