Obesity最新文献

{"title":"The associations among maternal gestational weight gain, cord blood DNA methylation, and offspring childhood high BMI","authors":"Yuanyuan Zhang,&nbsp;Hong Mei,&nbsp;Ruixia Chang,&nbsp;Chunan Li,&nbsp;Hongzhong Zhang,&nbsp;Jianduan Zhang","doi":"10.1002/oby.24257","DOIUrl":"10.1002/oby.24257","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to explore the associations among maternal gestational weight gain (GWG), cord blood DNA methylation, and high BMI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using the Illumina Infinium MethylationEPIC Bead Chip, GWG-related methylation sites were screened in 40 cord blood samples using a cohort design, and the association of these sites with children's BMI status at 3 years was examined. Sites simultaneously related to GWG and children's BMI were validated in an external dataset. The mediation effect of target differential methylation probes in the association between GWG and children's BMI was also explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 66 GWG-related differential methylation probes in cord blood, and four sites, including cg09973771 (<i>SNTG2</i>), cg00254258 (<i>PRDM16</i>), cg02672830 (<i>MCPH1</i>), and cg15424377, were found to be associated with children's BMI at age 3 years. The mediating effect of cord blood DNA methylation was not detected in the association between GWG and children's high BMI status. Out of the four sites screened, methylation level of site cg09973771 (<i>SNTG2</i>) in peripheral blood showed nominal significant differences among children with different BMI statuses at age 3 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Maternal GWG and childhood BMI status at age 3 years were associated with newborn cord blood DNA methylation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"766-776"},"PeriodicalIF":4.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mealtime clocking versus calorie counting for weight loss","authors":"Leinys S. Santos-Báez,&nbsp;Blandine Laferrère","doi":"10.1002/oby.24260","DOIUrl":"10.1002/oby.24260","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"627-628"},"PeriodicalIF":4.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical benefits and economic value of weight loss in a Swedish population using a simulation model","authors":"Marije Galavazi,&nbsp;Ville Wallenius,&nbsp;Volker Schnecke,&nbsp;Åsa Ericsson,&nbsp;Helena Björklund,&nbsp;Johan Jendle","doi":"10.1002/oby.24232","DOIUrl":"10.1002/oby.24232","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to estimate the 10-year clinical benefits and economic value of weight loss in a Swedish population with obesity using a value of weight-loss simulation model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data on the prevalence of and costs associated with obesity and obesity-related complications (ORCs) were applied within an adapted simulation model to evaluate weight-loss benefits for a 2023 Swedish population over 10 years. The 10-year incidence of 10 ORCs and treatment costs in a random cohort of 10,000 individuals were estimated for a stable weight scenario and four weight-loss (5%–20%) scenarios.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The model included 887,272 individuals with obesity aged 20 to 60 years. Hypertension (24.1%), asthma (20.9%), dyslipidemia (18.3%), and type 2 diabetes (10.6%) were highly prevalent. For 10,000 individuals, a 5% to 20% weight loss was estimated to prevent ORCs over 10 years, leading to annual savings between 9.0 million Swedish krona (SEK)/€0.8 million (5% weight loss) and 30.0 million SEK/€2.6 million (20%) by 2033.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Annual treatment costs of ORCs in Sweden will double over 10 years, and weight loss would be associated with significant savings because of the reductions in the incidence of ORCs. Therefore, there is an urgent need to effectively treat obesity to prevent morbidity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"777-787"},"PeriodicalIF":4.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-pregnancy per- and polyfluoroalkyl substances and maternal post-pregnancy weight trajectory","authors":"Jordan A. Burdeau,&nbsp;Briana J. K. Stephenson,&nbsp;Izzuddin M. Aris,&nbsp;Shruthi Mahalingaiah,&nbsp;Jorge E. Chavarro,&nbsp;Emma V. Preston,&nbsp;Marie-France Hivert,&nbsp;Emily Oken,&nbsp;Antonia M. Calafat,&nbsp;Sheryl L. Rifas-Shiman,&nbsp;Ami R. Zota,&nbsp;Tamarra James-Todd","doi":"10.1002/oby.24250","DOIUrl":"10.1002/oby.24250","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to evaluate associations of early-pregnancy plasma per- and polyfluoroalkyl substances (PFAS) with maternal post-pregnancy weight trajectory parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We studied 1106 Project Viva participants with measures of early-pregnancy plasma concentrations of eight PFAS. We measured weight at in-person visits at 6 months and 3, 7, and 12 years after pregnancy and collected self-reported weight via annual questionnaires up to 17 years after pregnancy. Weight trajectory parameters were estimated via the Superimposition by Translation and Rotation model. We assessed individual and joint effects of PFAS with trajectory parameters using linear regression and Bayesian kernel machine regression (BKMR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Perfluorooctane sulfonate (PFOS) concentrations were positively associated with weight trajectory magnitude in both linear regression (0.8 kg [95% CI: 0.1 to 1.4] per doubling of PFOS) and BKMR analyses (2.6 kg [95% CI: 1.4 to 3.8] per increase from 25th to 75th percentile of PFOS concentrations). Conversely, in BKMR analyses, perfluorononanoate was negatively associated with trajectory magnitude (−2.0 kg [95% CI: −2.9 to −1.1]). In stratified linear regression, older-aged participants had more pronounced positive associations of PFOS, perfluorooctanoate, and 2-(N-ethyl-perfluorooctane sulfonamido) acetate with weight trajectory velocity. No associations were observed with the overall PFAS mixture.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Select PFAS, assessed in pregnancy, may affect maternal weight trajectories spanning 17 years after pregnancy, especially for older-aged individuals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"807-816"},"PeriodicalIF":4.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial cell alterations in capillaries of adipose tissue from patients affected by lipedema","authors":"Sandro Michelini,&nbsp;Stefania Greco,&nbsp;Nicola Vaia,&nbsp;Valeria Puleo,&nbsp;Pamela Pellegrino,&nbsp;Angelica Di Vincenzo,&nbsp;Serena Michelini,&nbsp;Karen L. Herbst,&nbsp;Gaia Goteri,&nbsp;Tonia Luca,&nbsp;Sergio Castorina,&nbsp;Antonio Giordano,&nbsp;Pasquapina Ciarmela,&nbsp;Saverio Cinti","doi":"10.1002/oby.24244","DOIUrl":"10.1002/oby.24244","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to evaluate adipose tissue of lipedema patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Gluteo-femoral (affected area) and interscapular (nonaffected area) adipose tissue from 10 lean patients affected by lipedema stage 1 to 2 was studied and compared with tissue from 10 patients with obesity and 12 lean patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The main features were alterations of capillaries with wall thickening (<i>p</i> ≤ 0.0001), endothelial and pericyte hyperplasia (<i>p</i> = 0.03 and <i>p</i> = 0.004), hypodense areas in basal membrane, and endothelial degeneration with exfoliation of degenerated cells into the capillary lumen. Adipocytes were larger (hypertrophic) in affected (<i>P</i> ≤ 0.0001) and nonaffected (<i>p</i> = 0.0003) areas compared with those with obesity and who were lean (both <i>p</i> ≤ 0.0001). Frequently the cytoplasm of adipocytes contained massive deposition of calcium crystals as revealed by Von Kossa staining (<i>p</i> = 0.023) and electron microscopy. CD68 immunoreactive macrophages were more abundant in affected areas (<i>p</i> = 0.005), and their number was similar to that found in fat from patients with obesity (<i>p</i> = 0.17). Despite adipocyte hypertrophy and inflammation, lack of the healthy marker perilipin-1 and the presence of crown-like structures were only rarely seen, while they were quite frequent in patients with obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our data support the idea that cell alterations happen in the early stages of adipocyte development (endothelium/pericyte) in the adipose organ of women affected by lipedema.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"695-708"},"PeriodicalIF":4.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24244","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight-loss interventions for adolescents with Down syndrome: a systematic review","authors":"Thessa I.M. Hilgenkamp,&nbsp;Emily Davidson,&nbsp;Keith M. Diaz,&nbsp;Richard Fleming,&nbsp;Rachel Foster Kirk,&nbsp;Mary Hastert,&nbsp;Judy Kim,&nbsp;Sarah Mann,&nbsp;John Usseglio,&nbsp;Andrea Videlefsky,&nbsp;Lauren Ptomey","doi":"10.1002/oby.24233","DOIUrl":"10.1002/oby.24233","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Youth with Down syndrome (DS) experience high rates of overweight and obesity; therefore, weight-loss interventions are warranted. We aimed to systematically review weight-loss interventions for adolescents with DS to better understand the most effective strategies and identify the current gaps in the literature.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (International Prospective Register of Systematic Reviews [PROSPERO] #CRD42022303781). Databases were searched through July 28, 2023, and screening, evaluation, and data extraction were performed by two independent reviewers. Change scores for weight or BMI were presented by study design and intervention components.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 26 included papers describing 24 unique studies included a total of <i>n</i> = 1171 participants, of whom <i>n</i> = 393 were participants with DS. Eleven studies focused on physical activity, one on diet, and two on physical activity and diet; seven studies used multicomponent interventions; and three studies investigated laparoscopic sleeve gastrectomy. Thirteen studies using either a multicomponent intervention, a physical activity intervention, or surgery resulted in weight loss or a decrease in BMI in adolescents with DS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Weight-loss interventions can be effective for adolescents with DS and could benefit from increasing duration/intensity to meet the existing weight-loss intervention recommendations. More research on surgery and weight-loss medications is needed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"632-658"},"PeriodicalIF":4.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular remodeling of adipose tissue in lipedema: endothelial dysfunction as an emerging culprit in a mysterious disease","authors":"Timothy D. Allerton","doi":"10.1002/oby.24281","DOIUrl":"10.1002/oby.24281","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"629-631"},"PeriodicalIF":4.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a novel approach to assess metabolic flexibility to a high-fat meal in a whole-body room calorimeter","authors":"David H. McDougal,&nbsp;Guillermo Sanchez-Delgado,&nbsp;Emily W. Flanagan,&nbsp;Kara L. Marlatt,&nbsp;Joshua R. Sparks,&nbsp;Shengping Yang,&nbsp;Leanne M. Redman,&nbsp;Eric Ravussin","doi":"10.1002/oby.24245","DOIUrl":"10.1002/oby.24245","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Metabolic inflexibility to Western high-fat diets may contribute to the obesity epidemic. However, validated methods for assessing metabolic flexibility (MetFlex) to high-fat meals are currently lacking. The purpose of this study was to evaluate the reliability of a novel approach for determining MetFlex to a high-fat meal and to compare it with the gold standard for measuring MetFlex to high-carbohydrate loads.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eight healthy adults were enrolled in our study, which consisted of the following two assessments of MetFlex: 1) MetFlex to fat, via two overnight stays in a metabolic chamber separated by 5 to 7 days; and 2) Metflex to carbohydrates, via a two-step hyperinsulinemic-euglycemic clamp measured &gt;5 days later.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants were predominantly White and male, with mean (SD) age of 29.4 (6.3) years and BMI of 25.4 (4.1) kg/m². MetFlex to fat displayed satisfactory test–retest reliability (intraclass correlation coefficient &gt; 0.70) for several outcomes but showed no correlation to MetFlex measured during the clamp.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overnight changes in substrate oxidation following a high-fat dinner meal represent a unique aspect of MetFlex that cannot be captured using more conventional methods. Our findings warrant prospective studies to determine whether these parameters are predictive of the development of obesity or metabolic dysfunction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"743-753"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food-related implicit associations predict self-reported eating behaviors and dietary habits in large US samples","authors":"Matt B. Siroty,&nbsp;Julia M. P. Bittner,&nbsp;Jennifer L. Howell,&nbsp;Bobby K. Cheon","doi":"10.1002/oby.24247","DOIUrl":"10.1002/oby.24247","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Implicit associations, i.e., automatically activated attitudes and intuitions, may contribute to isolated food choices and body weight. Studies of food-related implicit associations have yielded mixed results and have not explored their role in eating behaviors or dietary patterns. We examined implicit associations toward the palatability and acceptability (vs. shame) of healthy food and their relationships with self-reported eating behaviors (eating in absence of hunger) and dietary patterns (fruit, vegetable, and sugar-sweetened beverage consumption) and socioeconomic indicators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Two US samples (i.e., Palatable Food, <i>n</i> = 11,504; and Acceptable Food, <i>n</i> = 12,128) from Project Implicit Health were analyzed. Implicit associations were measured with Implicit Association Tests. Linear and logistic regressions examined associations of implicit and related explicit self-reported responses (perceived healthy eating and acceptability of healthy food, respectively) with eating behaviors, dietary patterns, and socioeconomic indicators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One-sample <i>t</i> tests revealed health-favoring implicit palatability and acceptability associations. Implicit associations predicted healthier self-reported eating behaviors and dietary patterns independent of explicit responses. There were inconsistent associations with socioeconomic indicators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Health-favoring implicit food-related associations uniquely contribute to healthier eating behaviors and dietary patterns. These health-favoring associations could be a promising, yet underrecognized, target to promote healthier diets in the United States.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"796-806"},"PeriodicalIF":4.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical analysis of dual-energy x-ray absorptiometry—measured body composition changes with voluntary weight loss","authors":"Steven B. Heymsfield,&nbsp;Sophia Ramirez,&nbsp;Shengping Yang,&nbsp;Diana M. Thomas,&nbsp;Justin C. Brown,&nbsp;Stephanie L. E. Compton,&nbsp;John M. Schuna Jr.,&nbsp;Steven R. Smith,&nbsp;David S. Ludwig,&nbsp;Cara B. Ebbeling","doi":"10.1002/oby.24255","DOIUrl":"10.1002/oby.24255","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>When treated with a macronutrient-balanced hypocaloric diet, do male individuals who have overweight and obesity lose relatively more dual-energy x-ray absorptiometry (DXA)-measured lean soft tissue (LST) mass than female individuals? Are there changes in bone mineral content (BMC), and if so, how do they impact relative reductions in LST compared to fat-free mass (FFM; LST plus BMC)? Are decrements in fat, LST, and FFM predictable from the magnitude of weight loss or baseline body composition?</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To answer these questions, DXA studies were conducted before and after a 9- to 12-week calorie-restriction period in 43 male and 97 female individuals who lost a mean (SD) of 10.8% (2.2%) and 10.7% (1.6%) of their baseline weight, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The proportion of weight loss as LST was significantly (<i>p</i> &lt; 0.001) larger in male (mean [SD], 0.33 [0.11] kg) than female individuals (0.25 [0.11] kg); BMC paradoxically increased, thereby leading to a significantly smaller reduction in FFM than LST in the male (−3.87 [1.73] kg vs. −3.92 [1.74] kg; <i>p</i> &lt; 0.001) and female individuals (−2.22 [1.18] kg vs. −2.24 [1.18] kg; <i>p</i> &lt; 0.001), and three different analyses showed that the composition of weight loss tracked as predicted a priori from weight change and baseline body composition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These observations provide insights into and future guidance for analyzing the DXA-measured body composition changes associated with newer pharmacotherapies for weight loss.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"685-694"},"PeriodicalIF":4.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}