Obesity最新文献

{"title":"Response to Swoap et al.","authors":"Gwang-woong Go, Wooki Kim","doi":"10.1002/oby.24301","DOIUrl":"10.1002/oby.24301","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional mobility and pain are improved for 6 years after adolescent bariatric surgery","authors":"Neil Thivalapill,&nbsp;Todd M. Jenkins,&nbsp;Thomas H. Inge,&nbsp;Changchun Xie,&nbsp;Anita P. Courcoulas,&nbsp;Carroll M. Harmon,&nbsp;Michael A. Helmrath,&nbsp;Stephanie Sisley,&nbsp;Marc P. Michalsky,&nbsp;Justin R. Ryder,&nbsp;Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) consortium","doi":"10.1002/oby.24285","DOIUrl":"10.1002/oby.24285","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The long-term durability of improvements in functional mobility and musculoskeletal pain for adolescents after metabolic and bariatric surgery (MBS) is unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study to determine the change in mobility and pain among adolescents who underwent MBS. From standardized 400-m walk tests, we analyzed walk time, heart rate (HR) parameters, and musculoskeletal pain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean walk time improved from 383 s (95% CI: 368–399) prior to surgery to 351 s (95% CI: 330–372) by 6 years. The mean resting HR was 90 beats per minute (bpm; 95% CI: 87–93) preoperatively and decreased to 80 bpm (95% CI: 76–84) by 6 years. The risk of any musculoskeletal pain decreased from 37.2% (95% CI: 25.5%–48.9%) to 11.0% (95% CI: 4.3%–17.6%) by 6 years. Mediation analysis revealed that the effect of time since surgery on walk time, resting HR, and HR recovery occurred through a weight-dependent mechanism. For posttest HR and HR difference, there was both a significant weight-dependent and weight-independent mechanism. The effect of surgery on the risk of musculoskeletal pain occurred through a weight-independent mechanism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Adolescents who underwent MBS experienced significant, durable improvement in mobility and pain, despite weight regain. Our models suggest that improvements may occur through a weight-independent mechanism.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":"1126-1135"},"PeriodicalIF":4.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24285","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the obesity paradox in polytrauma patients: survival benefit specifically in individuals with obesity class I","authors":"Hui-Tzung Luh,&nbsp;Tsung-Hung Wu,&nbsp;Lu-Ting Kuo,&nbsp;Shyr-Chyr Chen,&nbsp;Chin-Hua Su,&nbsp;Shu-Yu Tsao,&nbsp;Sung-Tsang Hsieh,&nbsp;Dar-Ming Lai,&nbsp;Chien-Chang Lee","doi":"10.1002/oby.24282","DOIUrl":"10.1002/oby.24282","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The “obesity paradox” suggests that higher BMI values might be protective in certain conditions. However, it is controversial in polytrauma patients, with different studies presenting varying results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 1234 polytrauma patients were categorized by World Health Organization Asia-Pacific BMI classifications. Primary outcomes were 30- and 365-day all-cause mortality. Secondary outcome was length of hospital stay. Inverse probability of treatment weighting was performed to minimize baseline bias. Cox proportional hazards models we used to assess the impact of BMI on mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 30-day mortality rates were 7.5%, 9.0%, 6.7%, 2.4%, and 2.6% for patients with underweight (&lt;18.5 kg/m²), normal weight (18.5–22.9 kg/m²), overweight (23.0–24.9 kg/m²), obesity class I (25.0–29.9 kg/m²), and obesity class II (&gt;30.0 kg/m²), respectively. The 365-day mortality rates were 12.5%, 15.0%, 12.6%, 7.5%, and 7.7%, respectively. Only obesity class I was associated with a significantly lower risk of 30-day (hazard ratio [HR] = 0.19, 95% CI: 0.06–0.66; <i>p</i> = 0.00864) and 365-day mortality (HR = 0.57, 95% CI: 0.33–0.99; <i>p</i> = 0.0448). Furthermore, patients with obesity class II had significantly shorter lengths of hospital stays compared with those with normal weight (mean [SE], 6.08 [7.06] vs. 12.50 [19.80] days; <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The obesity paradox survival advantage occurs only in polytrauma patients with obesity class I, whereas these with obesity class II tend to have shorter hospital stays.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":"1037-1047"},"PeriodicalIF":4.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Alternate-day fasting enhanced weight loss and metabolic benefits over pair-fed calorie restriction in obese mice”","authors":"Steven Swoap,&nbsp;Chloe Henderson,&nbsp;Damian Turner","doi":"10.1002/oby.24298","DOIUrl":"10.1002/oby.24298","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":"1019-1020"},"PeriodicalIF":4.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide-induced weight loss improves mitochondrial energy efficiency in skeletal muscle","authors":"Ran Hee Choi,&nbsp;Takuya Karasawa,&nbsp;Cesar A. Meza,&nbsp;J. Alan Maschek,&nbsp;Allison M. Manuel,&nbsp;Linda S. Nikolova,&nbsp;Kelsey H. Fisher-Wellman,&nbsp;James E. Cox,&nbsp;Amandine Chaix,&nbsp;Katsuhiko Funai","doi":"10.1002/oby.24274","DOIUrl":"https://doi.org/10.1002/oby.24274","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Glucagon-like peptide-1 receptor agonists (e.g., semaglutide) potently induce weight loss, thereby reducing obesity-related complications. However, weight regain occurs when treatment is discontinued. An increase in skeletal muscle oxidative phosphorylation (OXPHOS) efficiency upon diet-mediated weight loss has been described, which may contribute to reduced systemic energy expenditure and weight regain. We set out to determine the unknown effect of semaglutide on muscle OXPHOS efficiency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>C57BL/6J mice were fed a high-fat diet for 12 weeks before receiving semaglutide or vehicle for 1 or 3 weeks. The rates of ATP production and oxygen (O₂) consumption were measured via high-resolution respirometry and fluorometry to determine OXPHOS efficiency in muscle at these two time points.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Semaglutide treatment led to significant reductions in fat and lean mass. Semaglutide improved skeletal muscle OXPHOS efficiency, measured as ATP produced per O₂ consumed in permeabilized muscle fibers. Mitochondrial proteomic analysis revealed changes restricted to two proteins linked to complex III assembly (LYRM7 and TTC19; <i>p</i> &lt; 0.05 without multiple corrections) without substantial changes in the abundance of OXPHOS subunits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These data indicate that weight loss with semaglutide treatment increases skeletal muscle mitochondrial efficiency. Future studies could test whether it contributes to weight regain.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 5","pages":"974-985"},"PeriodicalIF":4.2,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24274","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the relationship between head circumference and MC4R deficiency from infancy to adulthood: a case–control study","authors":"Eline E. P. L. van der Walle,&nbsp;Cornelis J. de Groot,&nbsp;Lotte Kleinendorst,&nbsp;Hester de Klerk,&nbsp;Mila S. Welling,&nbsp;Ozair Abawi,&nbsp;Renate E. H. Meeusen,&nbsp;Mariëtte R. Boon,&nbsp;Elisabeth F. C. van Rossum,&nbsp;Mieke M. van Haelst,&nbsp;Erica L. T. van den Akker","doi":"10.1002/oby.24263","DOIUrl":"https://doi.org/10.1002/oby.24263","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to investigate head circumference (HC) in patients with melanocortin 4 receptor (MC4R) deficiency, the most common cause of monogenetic obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with (likely) pathogenic <i>MC4R</i> variants were included. HC, height, and weight were measured, and BMI and standard deviation score (SDS) were calculated. HC SDS was compared to the Dutch reference population. Children were matched 1:1 to a control group with common obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Children with MC4R deficiency (<i>n</i> = 63, mean age, 10.32 years) had significantly larger HC (mean, +1.73 SDS) compared to the reference population (0 SDS; <i>p</i> &lt; 0.001) and controls (+1.22 SDS; <i>p</i> = 0.009). In adults (<i>n</i> = 13), HC (median, + 0.86 SDS) did not differ from the reference population (0 SDS; <i>p</i> = 0.152). Macrocephaly (HC ≥ 2 SDS) was present in 43%, 25%, and 23% of pediatric patients with MC4R deficiency, controls, and adult patients, respectively. Children with MC4R deficiency were taller than controls (+1.00 SDS vs. +0.42 SDS; <i>p</i> = 0.016), with similar BMI (+3.99 SDS vs. +3.75 SDS; <i>p</i> = 0.157). HC SDS was associated with height SDS (<i>R</i>², 0.22; <i>p</i> &lt; 0.001) and homeostatic model assessment of insulin resistance (correlation coefficient, 0.542; <i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Macrocephaly is a common feature of patients with MC4R deficiency. We recommend measuring HC in patients suspected for genetic obesity, as it can be a clue for MC4R deficiency.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 5","pages":"986-995"},"PeriodicalIF":4.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapting anti-tobacco messages to ultraprocessed foods: message framing's impact on attitudes toward the food industry","authors":"Kathleen E. Good,&nbsp;Lindsey Parnarouskis,&nbsp;Jenna R. Cummings,&nbsp;Ashley N. Gearhardt","doi":"10.1002/oby.24272","DOIUrl":"https://doi.org/10.1002/oby.24272","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Ultraprocessed food consumption is associated with worse health. Ultraprocessed food companies apply production and advertising tactics used for tobacco products. Anti-tobacco campaigns that have highlighted industry manipulation have reduced youth tobacco use and increased support for tobacco-related policies. This study explored whether similar messaging affected attitudes and beliefs toward the food industry, support for obesity-related policies, and weight stigma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants aged 18 to 25 years were randomized to watch presentations emphasizing the following: 1) food industry manipulation and product addictiveness; 2) food industry manipulation and product health harms; 3) individual choices and food addiction; 4) individual choices and health harms; or 5) a control. Participants completed questionnaires regarding attitudes and beliefs toward the food industry, support for obesity-related policies, and weight stigma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Messages that emphasized food industry manipulation and product addictiveness were associated with increased negative attitudes toward the food industry versus control. Industry-focused messages were associated with increased negative beliefs regarding industry practices versus control. No significant effects were observed on support for obesity-related policies and weight stigma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Emphasizing food industry manipulation and product addictiveness appears promising for shifting youth attitudes toward the food industry without increasing weight stigma. Further research is needed to identify messages that shift support for obesity-related policies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 5","pages":"903-914"},"PeriodicalIF":4.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age, race and ethnicity, and sex of participants in clinical trials related to obesity","authors":"Leah M. Schumacher,&nbsp;Joseph Chibueze,&nbsp;Francesca M. Knudsen,&nbsp;Astha Rajpal,&nbsp;Siddhartha Kalala,&nbsp;Ksenia Power,&nbsp;Julie K. Silver,&nbsp;Helen Burton-Murray","doi":"10.1002/oby.24273","DOIUrl":"https://doi.org/10.1002/oby.24273","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Federal policies mandate the inclusion of historically marginalized groups in clinical trials and sociodemographic reporting on ClinicalTrials.gov. This study used ClinicalTrials.gov to comprehensively assess sociodemographic reporting and representation in obesity-related trials.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Age, race and ethnicity, and sex data were extracted for interventional studies completed in the United States with results from January 1, 2012, to October 13, 2023. We assessed the frequency of sociodemographic reporting and sample representation (equitable, over, or under), as determined by comparing the percentage of trial participants with each characteristic to US Census data and obesity-specific estimates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The search yielded 847 study records, 449 of which were eligible. Most studies (&gt;99%) reported sex; older age (33%), race (75%), and ethnicity (57%) were less commonly reported, although race and ethnicity reporting increased over time (<i>p</i> values &lt;0.001). The following three patterns emerged for representation: 1) individuals identifying as Black/African American were slightly overrepresented relative to the comparators; 2) representation of older adults and other racial and ethnic identities was more mixed and differed by trial type; and 3) female participants were overrepresented.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Progress has been made in reporting and representation, although gaps remain. Given obesity-related health disparities and reasons for inclusion beyond population-based representation (e.g., subgroup analyses), continued efforts are needed to enhance reporting and representation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 5","pages":"915-926"},"PeriodicalIF":4.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruption of Ephb1 causes reduced hypothalamic CRH and TRH expression and obesity in mice","authors":"Simin Xie,&nbsp;Tao Zhao,&nbsp;Chengchen Hu,&nbsp;Yongyong Meng,&nbsp;Jing Cui,&nbsp;Xiaohui Wu","doi":"10.1002/oby.24275","DOIUrl":"10.1002/oby.24275","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Ephrin type-B receptor 1 (EphB1) is a receptor tyrosine kinase involved in axon guidance, synaptic plasticity, and tumorigenesis. However, the role of EphB1 in metabolic regulation and obesity remains poorly understood. This study aims to uncover the role of EphB1 in energy metabolism and provide insights into the underlying mechanisms by which EphB1 regulates obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Two <i>Ephb1</i> mutations identified from a forward genetic screen for obesity-related loci in mice were examined for their effects in gene expression, energy metabolism, and endocrine changes. The impacts of EphB1 on neuropeptide expression and signal transduction were evaluated in both hypothalamic tissues and primary cells. Potential downstream signals were modified in <i>Ephb1</i> mutants to verify the interaction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><i>Ephb1</i> mutants develop obesity in adolescence and develop impaired glucose tolerance during adulthood. EphB1 deficiency caused lower body temperature, blunted cold-induced thermogenesis, and decreased locomotor activity, but it did not alter food intake. EphB1 promotes cyclic AMP-responsive element-binding protein (CREB) phosphorylation via phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling in a cell-autonomous manner. EphB1 deficiency leads to reduced expression of corticotropin-releasing hormone (CRH) and thyrotropin-releasing hormone (TRH) in the brain. Intraventricular administration of either TRH or a CRH fragment suppressed obesity in <i>Ephb1</i> mutants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>EphB1 regulates hypothalamic CRH and TRH expression and promotes energy expenditure in mice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":"1101-1112"},"PeriodicalIF":4.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific white matter alterations in children exposed to high pregestational BMI","authors":"Samson Nivins,&nbsp;Jess Reynolds,&nbsp;Gerald F. Giesbrecht,&nbsp;Deborah Dewey,&nbsp;Nicole Letourneau,&nbsp;Catherine Lebel","doi":"10.1002/oby.24277","DOIUrl":"10.1002/oby.24277","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study investigated whether exposure to high pregestational BMI (≥ 25 kg/m²) is associated with alterations in white matter microstructure in early childhood, explored sex-specific effects, and examined associations with cognitive performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 90 children from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort underwent diffusion tensor imaging between ages 2 and 7 years. Data were processed using ExploreDTI to obtain mean fractional anisotropy (FA) and mean diffusivity (MD). Pregestational weight was self-reported by pregnant individuals, height was measured at enrollment, and child cognitive outcomes were assessed at ages 3 to 4 years using the Wechsler Preschool and Primary Scale of Intelligence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Children exposed to high pregestational BMI had lower FA, but not higher MD, in the superior longitudinal fasciculus and in the body and splenium of the corpus callosum compared with unexposed children (BMI 18.5–24.9 kg/m²). This association persisted when analyzing pregestational obesity and overweight categories separately. Altered FA in splenium of the corpus callosum was associated with poorer cognitive outcomes in exposed children. Exposed male children had higher FA in the fornix, whereas female children had lower FA in the body and splenium of the corpus callosum compared with unexposed peers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>High pregestational BMI was associated with alterations in white matter microstructure during early childhood in a sex-specific manner. Promoting healthy lifestyles and weight management among individuals of childbearing age is crucial.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":"1113-1125"},"PeriodicalIF":4.2,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}