Obesity最新文献

{"title":"Nut consumption, gut microbiota, and body fat distribution: results of a large, community-based population study","authors":"Yuwei Shi,&nbsp;Juntao Kan,&nbsp;Wenjie Wang,&nbsp;Yiyang Cao,&nbsp;Yimian Wu,&nbsp;Xinyu Chen,&nbsp;Weifang Zheng,&nbsp;Fei Yang,&nbsp;Jun Du,&nbsp;Wei He,&nbsp;Shankuan Zhu","doi":"10.1002/oby.24099","DOIUrl":"10.1002/oby.24099","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We aimed to investigate the relationships among nut consumption, gut microbiota, and body fat distribution.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We studied 2255 Chinese adults in the Lanxi Cohort living in urban areas in Lanxi City, China. Fat distribution was assessed by dual-energy x-ray absorptiometry, and nut consumption was assessed using food frequency questionnaires. 16S ribosomal RNA (rRNA) sequencing was performed on stool samples from 1724 participants. Linear regression and Spearman correlation were used in all analyses. A validation study was performed using 1274 participants in the Lanxi Cohort living in rural areas.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nut consumption was beneficially associated with regional fat accumulation. Gut microbial analysis suggested that a high intake of nuts was associated with greater microbial α diversity. Six genera were found to be associated with nut consumption, and the abundance of genera <i>Anaerobutyricum</i>, <i>Anaerotaenia</i>, and <i>Fusobacterium</i> was significantly associated with fat distribution. Favorable relationships between α diversity and fat distribution were also observed. Similar relationships between gut microbiota and fat distribution were obtained in the validation analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We have shown that nut consumption is beneficially associated with body fat distribution and gut microbiota diversity and taxonomy. Furthermore, the microbial features related to high nut intake are associated with a favorable pattern of fat distribution.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 9","pages":"1778-1788"},"PeriodicalIF":4.2,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of an mHealth-delivered behavioral intervention on weight loss and cardiometabolic risk in African American postpartum people with overweight or obesity: the SnapBack randomized controlled trial","authors":"Sharon J. Herring,&nbsp;Daohai Yu,&nbsp;Niesha Darden,&nbsp;Brooke Bailer,&nbsp;Jane Cruice,&nbsp;Jessica J. Albert,&nbsp;Christine Santoro,&nbsp;Veronica Bersani,&nbsp;Chantelle N. Hart,&nbsp;Eric A. Finkelstein,&nbsp;Linda M. Kilby,&nbsp;Xiaoning Lu,&nbsp;Gary B. Bennett,&nbsp;Gary D. Foster","doi":"10.1002/oby.24091","DOIUrl":"10.1002/oby.24091","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to evaluate the efficacy of a mobile health (mHealth)-delivered behavioral intervention on changes in postpartum weight and cardiometabolic risk factors (blood pressure [BP], lipids, and hemoglobin A1c) over 12 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A randomized controlled trial of 300 African American postpartum people with overweight and obesity enrolled in Philadelphia Women, Infants, and Children (WIC) clinics was conducted. Participants were randomized to usual WIC care (<i>n</i> = 151) or a 12-month mHealth-delivered intervention (<i>n</i> = 149) comprising behavior change goals, interactive self-monitoring text messages, and counseling support.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Intervention and usual-care participants did not significantly differ in 12-month mean postpartum weight change (1.1 vs. 1.6 kg, <i>p</i> = 0.5; difference −0.6 kg, 95% CI: −2.3 to 1.2). However, high intervention engagement led to weight loss compared with weight gain among those who were less engaged (−0.6 vs. 2.4 kg, <i>p</i> = 0.01; difference −3.0 kg, 95% CI: −5.4 to −0.6). The intervention reduced systolic BP relative to usual care (−1.6 vs. 2.4 mm Hg, <i>p</i> = 0.02; difference −4.0 mm Hg, 95% CI: −7.5 to −0.5), but this effect did not extend to other cardiometabolic risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Among African American postpartum people enrolled in WIC, an mHealth-delivered intervention reduced systolic BP but not additional cardiometabolic risk factors or weight. Intervention participants with high engagement had significantly better postpartum weight outcomes, and thus, next steps include addressing barriers to engagement.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 9","pages":"1646-1657"},"PeriodicalIF":4.2,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic biomarkers related to obesity in heart failure with reduced ejection fraction and their associations with outcome","authors":"Teun B. Petersen,&nbsp;Navin Suthahar,&nbsp;Folkert W. Asselbergs,&nbsp;Marie de Bakker,&nbsp;K. Martijn Akkerhuis,&nbsp;Alina A. Constantinescu,&nbsp;Jan van Ramshorst,&nbsp;Peter D. Katsikis,&nbsp;Peter J. van der Spek,&nbsp;Victor A. Umans,&nbsp;Rudolf A. de Boer,&nbsp;Eric Boersma,&nbsp;Dimitris Rizopoulos,&nbsp;Isabella Kardys","doi":"10.1002/oby.24094","DOIUrl":"10.1002/oby.24094","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Heart failure (HF) pathophysiology in patients with obesity may be distinct. To study these features, we identified obesity-related biomarkers from 4210 circulating proteins in patients with HF with reduced ejection fraction (HFrEF) and examined associations of these proteins with HF prognosis and biological mechanisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In 373 patients with trimonthly blood sampling during a median follow-up of 2.1 (25th–75th percentile: 1.1–2.6) years, we applied an aptamer-based multiplex approach measuring 4210 proteins in baseline samples and the last two samples before study end. Associations between obesity (BMI &gt; 30 kg/m²) and baseline protein levels were analyzed. Subsequently, associations of serially measured obesity-related proteins with biological mechanisms and the primary endpoint (PEP; composite of cardiovascular mortality, HF hospitalization, left ventricular assist device implantation, and heart transplantation) were examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Obesity was identified in 26% (96/373) of patients. A total of 30% (112/373) experienced a PEP (with obesity: 26% [25/96] vs. without obesity: 31% [87/277]). A total of 141/4210 proteins were linked to obesity, reflecting mechanisms of neuron projection development, cell adhesion, and muscle cell migration. A total of 50/141 proteins were associated with the PEP, of which 12 proteins related to atherosclerosis or hypertrophy provided prognostic information beyond clinical characteristics, N-terminal pro-B-type natriuretic peptide, and high-sensitivity troponin T.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <div>Patients with HFrEF and obesity show distinct proteomic profiles compared to patients with HFrEF without obesity. Obesity-related proteins are independently associated with HF outcome. These proteins carry potential to improve management of obesity-related HF and could be leads for future research.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 9","pages":"1658-1669"},"PeriodicalIF":4.2,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory nutrition: lessons learned and opportunities","authors":"Richard D. Mattes","doi":"10.1002/oby.24089","DOIUrl":"10.1002/oby.24089","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 8","pages":"1421-1424"},"PeriodicalIF":4.2,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fas (CD95) expression in adipocytes contributes to diet-induced obesity","authors":"Stephan Wueest,&nbsp;Chiara Scaffidi,&nbsp;Pim P. van Krieken,&nbsp;Nils K. Konrad,&nbsp;Christian Koch,&nbsp;Michael S. F. Wiedemann,&nbsp;Anne Goergen,&nbsp;Marcela Borsigova,&nbsp;Ioannis G. Lempesis,&nbsp;Jonas Fullin,&nbsp;Konstantinos N. Manolopoulos,&nbsp;Steffen Böttcher,&nbsp;Gijs H. Goossens,&nbsp;Matthias Blüher,&nbsp;Daniel Konrad","doi":"10.1002/oby.24092","DOIUrl":"10.1002/oby.24092","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Induction of browning in white adipose tissue (WAT) increases energy expenditure and may be an attractive target for the treatment of obesity. Since activation of Fas (CD95) induces pathways known to blunt expression of uncoupling protein 1 (UCP1), we hypothesized that Fas expression in adipocytes inhibits WAT browning and thus contributes to the development of obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adipocyte-specific Fas knockout (Fas^Δadipo) and control littermate (Fas^F/F) mice were fed a regular chow diet or a high-fat diet (HFD) for 20 weeks. Energy expenditure was assessed by indirect calorimetry, and browning was determined in subcutaneous WAT. In vitro, UCP1 was analyzed in subcutaneous murine adipocytes treated with or without Fas ligand. Moreover, <i>FAS</i> expression in WAT was correlated to <i>UCP1</i> and percentage of body fat in human individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>HFD-fed Fas^Δadipo mice displayed reduced body weight gain and blunted adiposity compared to control littermates. Concomitantly, whole-body energy expenditure and WAT browning were elevated. In cultured adipocytes, Fas ligand treatment blunted isoproterenol-induced UCP1 protein levels. In support of these findings in rodents, <i>FAS</i> expression in WAT correlated negatively with <i>UCP1</i> but positively with adiposity in human individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Fas activation in adipocytes contributes to HFD-associated adiposity in rodents and may be a therapeutic target to reduce obesity and associated diseases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 10","pages":"1812-1818"},"PeriodicalIF":4.2,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity- and diet-induced plasticity in systems that control eating and energy balance","authors":"Carrie R. Ferrario,&nbsp;Heike Münzberg-Gruening,&nbsp;Linda Rinaman,&nbsp;J. Nicholas Betley,&nbsp;Stephanie L. Borgland,&nbsp;Monica Dus,&nbsp;Debra A. Fadool,&nbsp;Kathryn F. Medler,&nbsp;Gregory J. Morton,&nbsp;Darleen A. Sandoval,&nbsp;Claire B. de La Serre,&nbsp;Sarah A. Stanley,&nbsp;Kristy L. Townsend,&nbsp;Alan G. Watts,&nbsp;Padma Maruvada,&nbsp;Diana Cummings,&nbsp;Bradley M. Cooke","doi":"10.1002/oby.24060","DOIUrl":"10.1002/oby.24060","url":null,"abstract":"<p>In April 2023, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in partnership with the National Institute of Child Health and Human Development, the National Institute on Aging, and the Office of Behavioral and Social Sciences Research, hosted a 2-day online workshop to discuss neural plasticity in energy homeostasis and obesity. The goal was to provide a broad view of current knowledge while identifying research questions and challenges regarding neural systems that control food intake and energy balance. This review includes highlights from the meeting and is intended both to introduce unfamiliar audiences with concepts central to energy homeostasis, feeding, and obesity and to highlight up-and-coming research in these areas that may be of special interest to those with a background in these fields. The overarching theme of this review addresses plasticity within the central and peripheral nervous systems that regulates and influences eating, emphasizing distinctions between healthy and disease states. This is by no means a comprehensive review because this is a broad and rapidly developing area. However, we have pointed out relevant reviews and primary articles throughout, as well as gaps in current understanding and opportunities for developments in the field.</p>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 8","pages":"1425-1440"},"PeriodicalIF":4.2,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometry for predicting cardiometabolic disease risk factors in adolescents","authors":"Luyu Xie,&nbsp;Joohan Kim,&nbsp;Jaime P. Almandoz,&nbsp;John Clark,&nbsp;M. Sunil Mathew,&nbsp;Bethany R. Cartwright,&nbsp;Sarah E. Barlow,&nbsp;Steven E. Lipshultz,&nbsp;Sarah E. Messiah","doi":"10.1002/oby.24090","DOIUrl":"10.1002/oby.24090","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Early screening prevents chronic diseases by identifying at-risk adolescents through anthropometric measurements, but predictive value in diverse groups is uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional analysis of 12- to 19-year-old individuals from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) assessed the predictive ability of BMI percentile, total body fat percentage, waist circumference (WC), and waist-hip ratio (WHR) for four cardiometabolic risk factors across race and ethnicity groups using receiver operating characteristic curves.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The unweighted sample (<i>N</i> = 1194; 51.2% male individuals; 23.7% Hispanic, 13.2% non-Hispanic Black [NHB], 51.1% non-Hispanic White [NHW], 12.0% other/multirace) had a weighted prevalence of elevated blood pressure of 2.7%, hyperglycemia of 36.8%, hypertriglyceridemia of 4.8%, and low high-density lipoprotein (HDL) cholesterol of 15%. WHR (area under the curve [AUC] = 0.77), WC (AUC = 0.77), and BMI percentile (AUC = 0.73) outperformed total body fat percentage (AUC = 0.56) in predicting elevated blood pressure (<i>p</i> &lt; 0.001 for all). BMI percentile was more accurate than total body fat percentage in predicting hypertriglyceridemia (AUC = 0.70 vs. 0.59; <i>p</i> = 0.02) and low HDL cholesterol (AUC = 0.69 vs. 0.59; <i>p</i> &lt; 0.001). Race and ethnicity-based predictions varied: NHW adolescents had the highest AUC (0.89; <i>p</i> &lt; 0.01) for elevated blood pressure prediction compared with Hispanic and NHB adolescents (AUC = 0.77 for both). Total body fat percentage was more accurate in predicting low HDL cholesterol among Hispanic versus NHW adolescents (AUC = 0.73 vs. 0.58; <i>p</i> = 0.04).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>WHR, WC, and BMI percentile are better predictors of cardiometabolic risk factors in adolescents than total body fat percentage. Predictive abilities differed by race and ethnicity, highlighting the importance of tailored risk assessment strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 8","pages":"1558-1567"},"PeriodicalIF":4.2,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to review by Pan et al.","authors":"Ulf Holmbäck","doi":"10.1002/oby.24088","DOIUrl":"10.1002/oby.24088","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 9","pages":"1603-1604"},"PeriodicalIF":4.2,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Response to review by Pan et al.”","authors":"Xin-Hui Pan,&nbsp;Yip Han Chin,&nbsp;Mark Y. Chan,&nbsp;Nicholas W. S. Chew","doi":"10.1002/oby.24087","DOIUrl":"10.1002/oby.24087","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 9","pages":"1605-1606"},"PeriodicalIF":4.2,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dopamine production in neurotensin receptor 1 neurons is required for diet-induced obesity and increased day eating on a high-fat diet","authors":"Firozeh Farahmand,&nbsp;Michael Sidikpramana,&nbsp;Alyssa R. Gomez,&nbsp;Luis J. Rivera,&nbsp;Jacqueline R. Trzeciak,&nbsp;Sarah Sharif,&nbsp;Qijun Tang,&nbsp;Gina M. Leinninger,&nbsp;Ali D. Güler,&nbsp;Andrew D. Steele","doi":"10.1002/oby.24066","DOIUrl":"10.1002/oby.24066","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to determine a dopaminergic circuit required for diet-induced obesity in mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We created conditional deletion mutants for tyrosine hydroxylase (TH) using neurotensin receptor 1 (<i>Ntsr1</i>) <i>Cre</i> and other <i>Cre</i> drivers and measured feeding and body weight on standard and high-fat diets. We then used an adeno-associated virus to selectively restore TH to the ventral tegmental area (VTA) Ntsr1 neurons in conditional knockout (cKO) mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mice with cKO of <i>Th</i> using <i>Vglut2-Cre</i>, <i>Cck-Cre</i>, <i>Calb1-Cre</i>, and <i>Bdnf-Cre</i> were susceptible to obesity on a high-fat diet; however, <i>Ntsr1-Cre</i> <i>Th</i> cKO mice resisted weight gain on a high-fat diet and did not experience an increase in day eating unlike their wild-type littermate controls. Restoration of TH to the VTA Ntsr1 neurons of the <i>Ntsr1-Cre</i> <i>Th</i> cKO mice using an adeno-associated virus resulted in an increase in weight gain and day eating on a high-fat diet.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p><i>Ntsr1-Cre</i> <i>Th</i> cKO mice failed to increase day eating on a high-fat diet, offering a possible explanation for their resistance to diet-induced obesity. These results implicate VTA Ntsr1 dopamine neurons as promoting out-of-phase feeding behavior on a high-fat diet that could be an important contributor to diet-induced obesity in humans.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 8","pages":"1448-1452"},"PeriodicalIF":4.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}