Obesity最新文献

{"title":"Prevalence of Preclinical and Clinical Obesity Among US Children and Adolescents Aged 5 to 18 Years: NHANES 2017–2023","authors":"Priyanka Chaudhary,&nbsp;Shengping Yang,&nbsp;Stephanie Waldrop,&nbsp;Peter T. Katzmarzyk,&nbsp;Amanda E. Staiano","doi":"10.1002/oby.70198","DOIUrl":"10.1002/oby.70198","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to estimate the prevalence of preclinical and clinical obesity among US youth using the Lancet Diabetes &amp; Endocrinology Commission's framework.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study examined NHANES 2017–2023 data from 5513 youth aged 5–18. Obesity classification included: (i) no obesity (BMI &lt; 95th percentile and/or waist to height ratio (WHtR) &lt; 0.5), (ii) preclinical obesity (BMI ≥ 95th percentile and WHtR ≥ 0.5 without clinical impairment or functional limitations), and (iii) clinical obesity (BMI ≥ 95th percentile and WHtR ≥ 0.5 with one or more clinical impairments or functional limitations).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The weighted prevalence was 8.3% for preclinical and 12.5% for clinical obesity; combined prevalence (20.8%) was similar to ~22% using BMI percentile alone. Clinical obesity was more common in older children and racial/ethnic minority groups but similar by sex. Impairments associated with clinical obesity included low HDL cholesterol (60.3%), asthma (24.8%), early menarche in girls (18.0%), elevated blood pressure (16.2%), prediabetes/diabetes (9.1%), and functional limitations related to walking (7.7%) and self-care (4.1%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Applying the Lancet Diabetes &amp; Endocrinology Commission's new definition criteria revealed substantial physiological dysfunction in US youth. Applying preclinical and clinical obesity definitions is challenging, given the limitations of the routinely collected clinical and epidemiological data that make up NHANES and in standard clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 6","pages":"1230-1236"},"PeriodicalIF":4.7,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stopping Spin at the Source: Learning From an Example in Obesity","authors":"Andrew W. Brown,&nbsp;Michael Jensen,&nbsp;David B. Allison","doi":"10.1002/oby.70159","DOIUrl":"10.1002/oby.70159","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 6","pages":"1183-1186"},"PeriodicalIF":4.7,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Disease and Obesity Medications in Older Women by Obesity-Related Cancers Status: SEER-Medicare 2007–2015","authors":"David S. Lopez,&nbsp;Omer Abdelgadir,&nbsp;Yuanyi Zhang,&nbsp;Jesús Gibran Hernández-Pérez,&nbsp;Maryam R. Hussain,&nbsp;Mohanad Albayyaa,&nbsp;Rasmi Nair,&nbsp;Yong-Fang Kuo,&nbsp;Jaime P. Almandoz,&nbsp;Lindsay G. Cowell,&nbsp;Sarah E. Messiah","doi":"10.1002/oby.70211","DOIUrl":"10.1002/oby.70211","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study evaluated the association between antiobesity medications (AOM) and incident cardiovascular disease (CVD) among older women, examining this relationship within and across survivors of obesity-related cancers (ORCa) and age-matched cancer-free populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study using SEER–Medicare data from 2007 to 2015. The study included 46,552 women aged ≥ 65 years: ORCa survivors (<i>n</i> = 23,276) and age- and index-matched cancer-free women (<i>n</i> = 23,276). Prediagnostic AOM prescriptions before CVD onset were examined using intent-to-treat (ITT) and per-protocol approaches. Multivariable Cox proportional hazards models estimated hazard ratios (HR) and 95% CI for incident CVD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In ITT analyses, AOM use was associated with lower CVD incidence in the composite analytic sample (HR = 0.80, 95% CI: 0.71–0.90) and among cancer-free women (HR = 0.70, 95% CI: 0.58–0.85). Among ORCa survivors, estimates suggested a similar direction but were not statistically significant. In per-protocol analyses, AOM use was associated with reduced CVD risk in ORCa survivors (HR = 0.74, 95% CI: 0.57–0.94) and cancer-free women (HR = 0.59, 95% CI: 0.45–0.77). These associations were more pronounced within the first 2 years of follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>AOM use was inversely associated with incident CVD among ORCa survivors and cancer-free women. Further studies of second-generation AOM, particularly glucagon-like peptide-1 receptor agonists, are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 6","pages":"1343-1353"},"PeriodicalIF":4.7,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Stopping Spin at the Source: Learning From an Example in Obesity”","authors":"Huasheng Xiang,&nbsp;Louis Goffe,&nbsp;Viviana Albani,&nbsp;Nasima Akhter,&nbsp;Amelia A. Lake,&nbsp;Heather Brown","doi":"10.1002/oby.70158","DOIUrl":"10.1002/oby.70158","url":null,"abstract":"&lt;p&gt;The authors of the Letter to the Editor “Stopping Spin at the Source: Learning from an Example in Obesity” (hereafter the authors of the Letter to the Editor) start their letter with an allegation of “spin.” This insinuation, made without providing any evidence, suggests that our research findings and communications are driven by an agenda (an allegation which if founded would then extend beyond the authors of our paper to the editors of &lt;i&gt;Obesity&lt;/i&gt;, who at the time of publication included one of the authors of the Letter to the Editor as Editor-in-Chief of the journal, the peer reviewers, and by extension the academic community as a whole). We are bound to observe that the authors of the Letter to the Editor's conflict of interest statement outlining the “grant, contract, equity, gift, travel, or consulting fee” is compressed as a list yet still runs to 283 words, detailing a range of food industry organizations with a history of lobbying to directly influence government policy around food and the food environment [&lt;span&gt;2-5&lt;/span&gt;]. It is impossible for us to establish their relationship with each entity within an extensive list of industry associations. Note that our conflict of interest statement amounts to four words: no conflict of interest.&lt;/p&gt;&lt;p&gt;As authors we reject the notion that the communication of this research constitutes spin. This is a peer reviewed article describing a quasi-experimental evaluation of a real-world policy implementation. We transparently presented our study objectives, outcomes, and findings (including uncertainty levels and limitations). We stand by the findings of this paper and reiterate that we have no commercial, academic, or other interests relevant to an evaluation of this policy.&lt;/p&gt;&lt;p&gt;The tobacco, alcohol, food, and agriculture industries use “Research Washing” such as funding research and/or academic positions to influence scientific principles and discourse [&lt;span&gt;6-8&lt;/span&gt;]. By creating links with researchers and scientists, these industries can make the claim that the evidence they disseminate to the public regarding their products is evidence-based. There is an increasing body of evidence detailing how the food industry is shaping principles of scientific integrity in nutrition science [&lt;span&gt;9&lt;/span&gt;]. Two of the authors of the Letter to the Editor who receive grant, contract, equity, gift, travel, or consulting fees from the food industry have a history of arguing against policy to reduce obesity rates [&lt;span&gt;10, 11&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;The foundation of the criticisms against our paper made by the authors of the Letter to the Editor incorrectly makes the claim that the &lt;b&gt;second&lt;/b&gt; objective: &lt;i&gt;to explore whether the policy is more effective in areas of higher deprivation that previously had a higher concentration of outlets, leading to a reduction in inequalities in childhood OWOB&lt;/i&gt; is a &lt;b&gt;secondary&lt;/b&gt; objective. This is categorically not the case. The aim of the paper as clearly stated in","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 6","pages":"1187-1189"},"PeriodicalIF":4.7,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Setmelanotide in Bardet-Biedl Syndrome: A 52-Week Comparison of Phase 3 Trial Participants With a Matched Registry Cohort”","authors":"","doi":"10.1002/oby.70194","DOIUrl":"10.1002/oby.70194","url":null,"abstract":"<p>\u0000 \u0000 <span>J. Argente</span>, <span>A. M. Haww</span>, <span>J. L. Schorfheide</span>, et al., “ <span>Setmelanotide in Bardet-Biedl Syndrome: A 52-Week Comparison of Phase 3 Trial Participants With a Matched Registry Cohort</span>,” <i>Obesity</i> <span>34</span> (<span>2026</span>): <span>579</span>–<span>587</span>. https://doi.org/10.1002/oby.70125.\u0000 </p><p>Table 2 is incorrect. The value for mean absolute change in BMI is missing a negative symbol. The correct value is CTE (95% CI): −4.5 (−5.7, −3.2).</p><p>Below is the correct Table 2.</p><p>We apologize for this error.</p>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 6","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Artemisia scoparia Extract and Rosiglitazone Have Distinct but Overlapping Effects on Adipocyte Function","authors":"Anik Boudreau,&nbsp;Lindsey Yoo,&nbsp;Innocence Harvey,&nbsp;Paula Mota de Sà,&nbsp;Pravalika Javvadi,&nbsp;Sujoy Ghosh,&nbsp;Allison J. Richard,&nbsp;Jacqueline M. Stephens","doi":"10.1002/oby.70196","DOIUrl":"10.1002/oby.70196","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>An \u0000 <i>Artemisia scoparia</i>\u0000 extract (SCO) has been shown to enhance adipocyte function, improve insulin sensitivity, and regulate lipolysis. We evaluated the actions of SCO and rosiglitazone (ROSI) in adipocytes, focusing on PPARγ's role in their regulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We assessed PPARγ activation by measuring its half-life and the PPAR-dependent transcription of a luciferase reporter. We measured glycerol release from adipocytes with siRNA gene silencing or pharmacological inhibition of PPARγ. Immunoblotting was used to detect adiponectin and protein disulfide isomerase (PDI); transcriptional effects in SCO- and ROSI-treated cells were compared by RNA-seq.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ROSI and SCO both enhanced PPARγ degradation, a hallmark of ligand-induced activation. PPARγ transcriptional activity was induced in three cell types by ROSI, but in only one by SCO. PPARγ knockdown reversed the antilipolytic effects of both SCO and ROSI, while pharmacological inhibition only reversed the effect of ROSI. SCO treatment, but not ROSI, produced reduction-resistant adiponectin multimers and high–molecular-weight complexes of PDI. Transcriptional changes were more pronounced with ROSI than SCO, although the affected pathways were largely overlapping.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>SCO is a context-dependent PPARγ agonist with unique effects on redox-dependent protein multimerization. Transcriptional profiling indicates that SCO acts as a partial or selective PPARγ agonist.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 6","pages":"1277-1288"},"PeriodicalIF":4.7,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental Communication With Children Around Obesity Management Medications, Weight Loss, and Health Behavior Change","authors":"Keeley J. Pratt,&nbsp;Selena Gonzlez-Jordan,&nbsp;Sabrena F. Noria,&nbsp;Joseph A. Skelton","doi":"10.1002/oby.70206","DOIUrl":"10.1002/oby.70206","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to describe parental communication with children around obesity management medications (OMMs) and child, parent, and family factors associated with communication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Parents (<i>N</i> = 211; 80% mothers; 89% White) prescribed OMMs at a medical center participated in a survey about communication with children about OMM use, weight, and health behaviors. Logistic regression models assessed associations between communication about OMMs and child weight, diet, and activity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among study participants, 50% of parents talked with their child about the decision to take OMMs; 75% talked openly about it. Parents with older children were more likely to have open communication about OMMs (OR = 1.10; <i>p</i> = 0.016). Parents with impaired family functioning were less likely to communicate about OMMs (OR = 0.23; <i>p</i> = 0.002). Children who made comments to parents about their own weight were more likely to notice parents' weight loss (OR = 2.70; <i>p</i> = 0.002), be older in age (OR = 1.13; <i>p</i> = 0.006), and have overweight (OR = 3.58; <i>p</i> &lt; 0.001). Parents who reported their child made comments about his or her own diet were more likely to report that their child noticed parents' diet change (OR = 4.40; <i>p</i> &lt; 0.001), had overweight (OR = 2.03; <i>p</i> = 0.046), and had healthy family functioning (OR = 0.42; 95% <i>p</i> = 0.025).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Parents are talking with their children about their OMMs and behaviors, especially with older children, children with overweight, and in families with healthy functioning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 6","pages":"1237-1242"},"PeriodicalIF":4.7,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Planetary Health Diet Adherence Improves Weight and Body Composition During Energy Restriction","authors":"Paola Mogna-Peláez,&nbsp;Naixin Zhang,&nbsp;Marta Guasch-Ferré,&nbsp;Fermin I. Milagro,&nbsp;José I. Riezu-Boj,&nbsp;José I. Herrero,&nbsp;Mariana Elorz,&nbsp;Alberto Benito-Boillos,&nbsp;Ana Luz Tobaruela-Resola,&nbsp;Amelia Marti Del Moral,&nbsp;Josep A. Tur,&nbsp;J. Alfredo Martínez,&nbsp;Itziar Abete,&nbsp;M. Ángeles Zulet","doi":"10.1002/oby.70215","DOIUrl":"10.1002/oby.70215","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Obesity management relies on energy restriction, yet the contribution of dietary quality to weight-loss and body composition outcomes during hypocaloric interventions remains poorly characterized. This study evaluated whether adherence to the Planetary Health Diet (PHD), as a measure of diet quality, and its key components is associated with weight loss and body composition during energy restriction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from 403 adults with overweight or obesity were analyzed at baseline and at 3, and 6 months across two controlled dietary interventions prescribing a 30% energy deficit. PHD adherence was quantified using an energy-adjusted score based on EAT–Lancet dietary targets. Excellent weight loss was defined as ≥ 10% body weight reduction. Associations were assessed using mixed models, logistic regression, and mediation analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Higher PHD adherence was associated with lower BMI, waist circumference, and body fat percentage. Participants in the highest-adherence quartile had lower BMI than those in the lowest-adherence quartile (−0.94 kg/m²; 95% CI: −1.62 to −0.31; <i>p</i> = 0.005). Each 10-point increase in adherence increased odds of achieving ≥ 10% weight loss by 49% (OR = 1.49; 95% CI: 1.03–2.16). Red and processed meat reduction and higher whole-grain intake mediated associations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Greater PHD adherence during energy restriction was associated with greater weight loss and improved body composition.</p>\u0000 \u0000 <p>\u0000 <b>Trail registration:</b> ClinicalTrials.gov identifiers NCT02737267 and NCT03183193</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 6","pages":"1265-1276"},"PeriodicalIF":4.7,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Time-Restricted Eating on Gut Microbiota and Metabolites and Their Relationship With Cardiometabolic Risk Factors","authors":"Li-Min Zhang,&nbsp;Zi-Dan Wang,&nbsp;Zheng Zhang,&nbsp;Jie Liu,&nbsp;Zhi-Hao Li,&nbsp;Yue-Rong Ren,&nbsp;Zhan Liu,&nbsp;Xiao Zhang,&nbsp;Xian-Yun Wang,&nbsp;Ke-Xin Qi,&nbsp;Chang Yuan,&nbsp;Hao Guo,&nbsp;Yi-Fei Zhang,&nbsp;Jun Ge,&nbsp;Yu-Xia Ma","doi":"10.1002/oby.70207","DOIUrl":"10.1002/oby.70207","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to investigate whether the time of the eating window during time-restricted eating (TRE) alters the gut microbiota and metabolomic profiles and to determine their relationship with cardiometabolic risk factors in adults with overweight or obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In an 8-week randomized controlled trial, 60 young adults with overweight or obesity were randomized to 6-h eTRE (7 a.m.–1 p.m.), 6-h lTRE (12 p.m.–6 p.m.), or a control group (ad libitum). The gut microbiota was analyzed by 16S ribosomal RNA (16S rRNA) sequencing and serum metabolomics were quantified by liquid chromatography-mass spectrometry (LC–MS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 8 weeks, compared to the control group, the 6-h eTRE increased abundance of <i>Faecalibacterium</i> and <i>Lactobacillus</i> and decreased abundance of unclassified_f_Peptostreptococcaceae, whereas 6-h lTRE significantly increased abundance of <i>Faecalibacterium</i> and decreased abundance of <i>Shigella</i> (all <i>p</i> &lt; 0.05). Differential serum metabolites (e.g., L-malic acid in eTRE; isovaleric acid in lTRE) were significantly associated with changes in weight, body fat, and systolic blood pressure (SBP) (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Time-restricted eating may be beneficial to weight loss and cardiometabolic health improvement by regulating gut microbiota and serum metabolites.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> Chinese Clinical Trial Registry ChiCTR2000039115.</p>\u0000 \u0000 <div>\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 6","pages":"1289-1299"},"PeriodicalIF":4.7,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Weight Status and Quality of Life Through Childhood and Adolescence: Australian Longitudinal Cohort Analysis","authors":"Alison Hayes,&nbsp;Thomas Lung,&nbsp;Kirsten Howard,&nbsp;Louise Baur,&nbsp;Anagha Killedar","doi":"10.1002/oby.70195","DOIUrl":"10.1002/oby.70195","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study examined the relationship between health-related quality of life (HRQoL) and weight status across the pediatric life course.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data from a cohort of 9745 children from the Longitudinal Study of Australian Children, with follow-up over 14 years. HRQoL was measured with the proxy parent-reported Pediatric Quality of Life Inventory (PedsQL). Healthy weight, overweight, obesity, and severe obesity were defined using World Health Organization standards. We investigated the association of child HRQoL and weight status during early childhood (2–5 years), middle childhood (6–11 years), and adolescence (12–17 years), after controlling for continuous age, sex, and socioeconomic position.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The negative association between HRQoL and weight status strengthened with increasing age group and higher weight status. Compared to healthy weight, mean (95% CI) differences in total PedsQL score for obesity were −0.9 (−1.7 to −0.2) in early childhood, −3.6 (−4.4 to −2.9) in middle childhood, and −5.5 (−6.4 to −4.6) in adolescence. Weight-associated loss of HRQoL was greatest for adolescents with severe obesity (BMI-<i>z</i> ≥ 3) at −10.5 points (95% CI: −12.9 to −8.1) lower than those in healthy weight.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The study highlights the important contribution of weight status to HRQoL during the child and adolescent life course.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 6","pages":"1314-1321"},"PeriodicalIF":4.7,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}