Obesity最新文献

{"title":"The Postpartum Pivot: A Critical Point in Life-Course Cardiometabolic Health","authors":"Amy R. Nichols, Emily Oken","doi":"10.1002/oby.70243","DOIUrl":"10.1002/oby.70243","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 7","pages":"1367-1368"},"PeriodicalIF":4.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction Between Genetic Risk and Parental Feeding Practices in the Prediction of Overweight Across Adolescence","authors":"Marthe de Roo,&nbsp;Tina Kretschmer,&nbsp;Clare Llewellyn,&nbsp;Bonamy R. Oliver,&nbsp;Catharina A. Hartman","doi":"10.1002/oby.70217","DOIUrl":"10.1002/oby.70217","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We examined whether genetic risk for higher BMI, parental feeding practices (restriction, pressure to eat, and monitoring), and their interactions were associated with overweight trajectories during adolescence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data came from 5568 participants aged 10–18 in the Twins' Early Development Study who had at least one measurement of weight. Parental feeding practices were reported at age 10 using the Child Feeding Questionnaire. A polygenic score for BMI was used as a proxy for genetic risk. We identified overweight trajectories using latent class growth analysis, and associations with genetic risk, feeding practices, and their interactions were tested using multinomial logistic regression with trajectory as the outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three trajectories were identified: non-overweight, persistent overweight, and adolescent-onset overweight. Higher genetic risk and greater parental restriction and monitoring were associated with persistent overweight, whereas pressure to eat was associated with non-overweight. Associations remained after adjustment for general parenting and additional risk factors. We found no evidence for gene–environment interaction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Genetic risk and parental feeding practices were independently associated with adolescent weight development. While this suggests feeding practices may be relevant targets for prevention, the findings likely represent complex bidirectional parent–child dynamics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 7","pages":"1468-1476"},"PeriodicalIF":4.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147871065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-Restricted Eating Promotes Weight Loss and Favorable Changes in Adipose in Obesity: The TREAD Randomized Control Trial","authors":"Michael J. Wilkinson,&nbsp;Erika Padilla,&nbsp;Yuqi Wang,&nbsp;Sawye Raygani,&nbsp;Emily N. C. Manoogian,&nbsp;Kyla Laing,&nbsp;Khang Tong,&nbsp;Lin Liu,&nbsp;David Van,&nbsp;Justina Nguyen,&nbsp;Alan R. Saltiel,&nbsp;Shannon M. Reilly,&nbsp;Monica O'Neal,&nbsp;Satchidananda Panda,&nbsp;Amit R. Majithia,&nbsp;Pam R. Taub","doi":"10.1002/oby.70228","DOIUrl":"10.1002/oby.70228","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Examine time-restricted eating (TRE) as a strategy to promote weight loss and cardiometabolic health in adults with obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>TRE in obesity and ADipose Tissue (TREAD) was a single-center 12-week RCT, involving 1:1 randomization to 10-h TRE versus standard of care (SOC) in adults with obesity (BMI 30–50 kg/m²) without diabetes and baseline eating window ≥ 14 h/day. The primary endpoint was change in weight (kg). Exploratory RNA-seq in subcutaneous abdominal adipose tissue was performed in a subgroup of participants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 61 participants were randomized, and 52 (26 TRE, 26 SOC) completed the study. Mean ± SD age was 55 ± 12.1 years, <i>n</i> = 35 were (58%) women, <i>n</i> = 35 were non-Hispanic White (58%), and BMI was 35.5 ± 4.8 kg/m². With TRE, the mean total reduction in weight from baseline to end of study was −4.59 kg (95% CI −5.51, −3.67) (−4.6%) versus −1.68 kg (95% CI −2.59, −0.77) (−1.7%) with SOC (between-group difference −2.91 kg [−4.21, −1.60]) (<i>p</i> &lt; 0.001), primarily through loss of body fat. Downregulation of proinflammatory genes was observed in adipose tissue during TRE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In adults with obesity, compared with SOC dietary counseling alone, TRE promotes weight loss, healthier body composition, and, in exploratory analyses, reduction in adipose tissue proinflammatory gene expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT04916730</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 7","pages":"1395-1408"},"PeriodicalIF":4.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70228","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Nutritional Priorities to Support GLP-1 Therapy for Obesity: A Joint Advisory From the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society”","authors":"","doi":"10.1002/oby.70222","DOIUrl":"10.1002/oby.70222","url":null,"abstract":"<p>D. Mozaffarian, M. Agarwal, M. Aggarwal, et al., “Nutritional Priorities to Support GLP-1 Therapy for Obesity: A Joint Advisory From the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society,” <i>Obesity (Silver Spring)</i> 33 (2025): 1475–1503. https://doi.org/10.1002/oby.24336\u0000 </p><p>The authors regret an error in the description of one study identified after publication. The original sentence “For instance, in one observational study, a larger reduction in added sugars and a greater increase in dietary protein were seen among participants receiving GLP-1s plus dietary counseling compared to GLP-1s alone [156],” has been corrected to “In one controlled trial, a larger reduction in added sugars and a greater increase in dietary protein were seen among participants randomized to a calorie-restricted diet with dietary counseling, compared to participants randomized to receive a GLP-1 (liraglutide) alone [156].” The authors note that this error did not affect any other portion of the manuscript or its conclusions.</p><p>The authors would like to apologize for any inconvenience caused. The authors would also like to acknowledge and thank Lindsay Christensen for pointing out the error.</p>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 7","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70222","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight Change Between Pregnancies and Mortality Over 50 Years of Follow-Up","authors":"Yajnaseni Chakraborti,&nbsp;Sunni L. Mumford,&nbsp;Edwina H. Yeung,&nbsp;Katherine L. Grantz,&nbsp;Pauline Mendola,&nbsp;James L. Mills,&nbsp;Ellen C. Caniglia,&nbsp;Colleen M. Brensinger,&nbsp;Cuilin Zhang,&nbsp;Enrique F. Schisterman,&nbsp;Stefanie N. Hinkle","doi":"10.1002/oby.70190","DOIUrl":"10.1002/oby.70190","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to evaluate the link between postpartum weight retention (PPWR) and long-term mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this secondary analysis of 8165 women with ≥ 2 pregnancies in the Collaborative Perinatal Project (CPP), U.S., 1959–1966, with vital status follow-up through 2016, we used interconception weight change (ICWC) and interpregnancy weight change (IPWC) as proxies of PPWR. ICWC was defined as the difference between self-reported pre-pregnancy weight from the 1st and 2nd CPP pregnancies, while IPWC was the difference between weight recorded at delivery of the 1st and pre-pregnancy weight of the 2nd CPP pregnancies. All-cause and cause-specific mortality models were adjusted for sociodemographic, behavioral, clinical, and pregnancy-related characteristics from the 1st CPP pregnancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to women with ICWC &gt; 0 to 1.8 kg (quintile 3), those with ICWC &gt; −1.4 to 0 kg (quintile 2) had a lower risk of all-cause mortality (aHR [95% CI]: 0.85 [0.76–0.96]), with the most notable reduction observed in diabetes-related risk of mortality (aHR [95% CI]: 0.45 [0.23–0.87]). Lower quintiles of IPWC (i.e., greater weight loss) were suggestive of reduced all-cause and cause-specific risk of mortality, though the estimates were not statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Minimizing PPWR was linked to reduced mortality risk over 50 years of follow-up.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 7","pages":"1502-1515"},"PeriodicalIF":4.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Association Between Weight Variability and Subsequent Long-Term Weight Loss in the CALERIE Study","authors":"Branislav Jovanovic,&nbsp;Simar Singh,&nbsp;Fengqing Zhang,&nbsp;Edward A. Williams,&nbsp;Susan B. Roberts,&nbsp;Michael R. Lowe","doi":"10.1002/oby.70235","DOIUrl":"10.1002/oby.70235","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Higher short-term weight variability (WV) predicts greater subsequent weight gain in weight-stable adults and toddlers and lower long-term weight loss among adults with overweight or obesity who previously lost weight. We extend prior work by examining the impact of naturally occurring WV on subsequent weight loss (weight at month 3 minus later weights) in individuals without obesity enrolled in the Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy (CALERIE) study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants (<i>N</i> = 143) followed a 25% caloric restriction diet over 2 years. WV was calculated as the root-mean-squared-error of individuals' weights over the first 12 weeks. Multilevel models examined WV's prediction of subsequent weight loss at 6, 12, 18, and 24 months relative to month 3, adjusting for baseline BMI, 12-week weight change, and demographic variables. Sensitivity analyses further included time-varying adherence and eating behaviors (disinhibition, restraint, craving).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Higher WV was associated with less subsequent weight loss at 6 months (<i>B</i> = −0.38, 95% CI [−0.63, −0.13], <i>β</i> = −0.16, <i>p</i> = 0.003). The interaction between time and WV was not significant; analyses suggested the association extends through year 1.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Short-term WV predicted lower subsequent weight loss in adults without obesity. Once its biobehavioral mechanisms are understood, WV might provide insight into humans' innate capacity for long-term weight stability and inform future mechanistic research and clinical interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>\u0000 ClinicalTrials.gov registration: NCT00427193\u0000 </p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 7","pages":"1409-1419"},"PeriodicalIF":4.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148280621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Horizons for the Ro Allison Indiana Dhurandhar Food Noise Inventory: Response to a Letter to the Editor","authors":"Misty A. W. Hawkins,&nbsp;John A. Jimenez-Garcia,&nbsp;Emily J. Dhurandhar,&nbsp;Kevin C. Maki,&nbsp;Nikhil V. Dhurandhar,&nbsp;Theodore K. Kyle,&nbsp;Sydney Yurkow,&nbsp;Jon Agley,&nbsp;Lawrence J. Cheskin,&nbsp;Thorkild I.A.Sørensen,&nbsp;Martin Binks,&nbsp;Xi (Rita) Wang,&nbsp;Bernard Gorman,&nbsp;Ariana M. Chao,&nbsp;David B. Allison,&nbsp;Emily H. Ho","doi":"10.1002/oby.70230","DOIUrl":"10.1002/oby.70230","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 7","pages":"1363-1364"},"PeriodicalIF":4.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Lipid Droplet–Associated Hydrolase Is Associated With Obesity and Adipose Tissue Inflammation in Children","authors":"Claudia Vales-Villamarín,&nbsp;Antje Berthold,&nbsp;Martin Lacher,&nbsp;Antje Körner,&nbsp;Kathrin Landgraf","doi":"10.1002/oby.70216","DOIUrl":"10.1002/oby.70216","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The lipid droplet–associated hydrolase (LDAH) is a lipid droplet–associated protein with an uncharacterized role in human adipose tissue (AT) and obesity; we aimed to investigate its role in human AT and its relevance for childhood obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>\u0000 <i>LDAH</i> variant rs13385191 and gene expression were analyzed in a cross-sectional study of subcutaneous AT samples from 296 children (120 girls, 176 boys; ages 0–18; BMI SDS −2.7 to 4.3), and an association with obesity and AT biology was studied. An effect of <i>LDAH</i> on adipogenesis was investigated in SGBS preadipocytes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Minor allele carriers of rs13385191 showed lower AT <i>LDAH</i> expression compared to non-carriers (<i>p</i> &lt; 0.001) and a trend toward higher BMI SDS, which was, however, not statistically significant (<i>p</i> = 0.062). Consistently, study participants with lower <i>LDAH</i> expression showed higher BMI SDS (<i>p</i> = 0.005). A negative correlation was found between <i>LDAH</i> and macrophage infiltration into AT after controlling for age (<i>R</i> = −0.132; <i>p</i> = 0.039), and high <i>LDAH</i> expression was associated with lower circulating TNFα (<i>p</i> = 0.017). <i>LDAH</i> expression increased during SGBS adipocyte differentiation, while its knockdown did not alter differentiation. In line with results from AT, TNFα significantly reduced <i>LDAH</i> expression in SGBS cells (<i>p</i> = 0.009).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>LDAH seems to have a role in AT inflammation and the development of obesity in children.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 7","pages":"1420-1432"},"PeriodicalIF":4.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148045353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation Associated With Obesity, Aging, and Amyloid Burden in Adults With Down Syndrome","authors":"Victoria L. Fleming-Batayneh,&nbsp;Brian C. Helsel,&nbsp;Lauren T. Ptomey,&nbsp;Benjamin L. Handen,&nbsp;Mark Mapstone,&nbsp;Melissa Petersen,&nbsp;Sharon J. Krinsky-McHale,&nbsp;Christy L. Hom,&nbsp;Davneet Minhas,&nbsp;Weiquan Luo,&nbsp;Charles Laymon,&nbsp;Joseph H. Lee,&nbsp;Annie Cohen,&nbsp;Beau M. Ances,&nbsp;Adam M. Brickman,&nbsp;Margaret Pulsifer,&nbsp;H. Diana Rosas,&nbsp;Florencia Lai,&nbsp;Shahid H. Zaman,&nbsp;Elizabeth Head,&nbsp;Dana Tudorascu,&nbsp;Julie Price,&nbsp;Fredrick Schmitt,&nbsp;Bradley T. Christian,&nbsp;Ozioma Okonkwo,&nbsp;Sigan L. Hartley,&nbsp;for the Alzheimer Biomarkers Consortium-Down Syndrome (ABC-DS) Investigators","doi":"10.1002/oby.70229","DOIUrl":"10.1002/oby.70229","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Adults with Down syndrome (DS) often show elevated systemic inflammation, but the association with obesity, aging, and Alzheimer's disease (AD) pathology is not well understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were drawn from 188 nondemented adults with DS participating in the Alzheimer Biomarkers Consortium-DS (ABC-DS). Participants completed clinical assessments, blood draws, and neuroimaging. Plasma biomarkers included indicators of general, pro-, and anti-inflammation. Mixed linear models tested associations between BMI, age, PET-measured amyloid burden, and inflammatory biomarkers, adjusting for sex, trisomy type, and collection site. False discovery rate correction was applied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The majority of the participants met criteria for obesity. Higher BMI was significantly associated with elevated levels of CRP, IL-6, TNF-α, B2M, IL-18, and slCAM-1 (<i>p</i> &lt; 0.05). Older age was significantly associated with higher B2M (<i>β</i> = 1.22e + 05, <i>p</i> &lt; 0.001). Amyloid burden was positively associated with IL-6 (<i>β</i> = 0.005, <i>p</i> = 0.037).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Obesity, aging, and amyloid burden relate to systemic inflammation in adults with DS. Obesity showed the strongest and most consistent associations, emphasizing the value of regular monitoring and weight management strategies to help reduce inflammation. Aging and early amyloid accumulation showed more limited links with systemic inflammation; future work should examine whether these processes are more closely related to biomarkers of neuroinflammation as AD progresses.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 7","pages":"1457-1467"},"PeriodicalIF":4.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.70229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148166266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial Transfer: A Novel Mechanism in the Development of Obesity and Obesity-Related Metabolic Diseases","authors":"Lei Zhu,&nbsp;Siyu Liang,&nbsp;Yuxing Zhao,&nbsp;Yi Hu,&nbsp;Fengying Gong,&nbsp;Huijuan Zhu","doi":"10.1002/oby.70223","DOIUrl":"10.1002/oby.70223","url":null,"abstract":"<div>\u0000 \u0000 <p>Obesity and its related metabolic diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD), represent a major global health challenge. Mitochondrial dysfunction is a key driver in their pathogenesis. This review explores the emerging role of mitochondrial transfer, a novel mode of cellular communication that can occur via tunneling nanotubes, extracellular vesicles, or as free mitochondria, in these conditions. Increasing evidence suggests that mitochondrial transfer may contribute to tissue homeostasis and metabolic adaptation, and that disruption of this process may participate in the pathogenesis of obesity and MASLD. In parallel, therapeutic strategies aimed at restoring mitochondrial function by enhancing endogenous mitochondrial transfer or through mitochondrial transplantation are beginning to emerge. This review summarizes current knowledge of the mechanisms underlying mitochondrial transfer, discusses roles in obesity and MASLD, and evaluates the therapeutic potential and translational challenges of targeting mitochondrial transfer in obesity and obesity-related metabolic disease.</p>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"34 7","pages":"1369-1381"},"PeriodicalIF":4.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147871041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}