Obesity最新文献

{"title":"Uncovering covariance patterns across energy balance traits enables the discovery of new obesity-related genes","authors":"Davorka Gulisija,&nbsp;Agustin Gonzalez-Reymundez,&nbsp;Jenifer I. Fenton,&nbsp;Gustavo de los Campos,&nbsp;Molly S. Bray,&nbsp;Ana I. Vazquez","doi":"10.1002/oby.24291","DOIUrl":"10.1002/oby.24291","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Effective solutions to obesity remain elusive, partly owing to its root in a positive energy balance (EB), which stems from the interplay of numerous traits spanning body size and composition, diet, physical activity, and metabolic profile. Nevertheless, EB-contributing traits are typically studied in isolation. We integrate numerous EB-related traits measured in the UK Biobank to uncover the underlying patterns of EB and associated genes in study participants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used sparse factor analysis to integrate traits and performed genome-wide association analyses on the integrated phenotypes to elucidate EB-related genes and metabolic pathways. We performed pleiotropy analyses on candidate single-nucleotide polymorphisms to uncover the genetic basis of EB.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified multiple genes and genomic regions associated with EB, including many that have previously not been directly associated with obesity measures (e.g., <i>MIR5591</i>, <i>FNDC3B</i>, <i>ANAPC10</i>, <i>SULT1A1</i>, <i>AXIN1</i>, <i>SKIDA1</i>, <i>ERLIN1</i>, <i>DOCK7</i>), which we validated using an independent subset of the UK Biobank dataset along with data from the Atherosclerosis Risk in Communities cohort. We found that the covariances in EB traits are primarily driven by genome-wide pleiotropic associations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We offer new insight into EB patterns and the genetic basis of EB.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":"1184-1194"},"PeriodicalIF":4.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24291","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Less frequent dosing of GLP-1 receptor agonists as a viable weight maintenance strategy","authors":"Calvin C. Wu,&nbsp;Anıl Cengiz,&nbsp;Sean D. Lawley","doi":"10.1002/oby.24302","DOIUrl":"10.1002/oby.24302","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Incretin mimetics are revolutionizing obesity treatment, but high prices and supply shortages limit patient access. Some clinicians have suggested less frequent dosing as an off-ramping strategy to maintain weight loss, but this approach lacks published evidence regarding its weight loss efficacy. We aim to provide such clinical evidence and to rationalize these results with mathematical modeling.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We present a real-world case series of two patients who took their incretin mimetic less frequently than recommended. We complement this case report with a pharmacokinetic-pharmacodynamic model of virtual patients that simulates long-term weight change with semaglutide and tirzepatide administered at various frequencies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both real-world and virtual patients maintained significant weight loss under reduced dosing frequencies. Our results indicate that reducing frequency does not commensurately reduce efficacy. The majority of weight loss persists even when patients wait 2, 3, or perhaps even 4 weeks between doses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings support the hypothesis that less frequent administration of incretin mimetics can be a viable and cost-saving long-term weight maintenance strategy in conjunction with sustained lifestyle modification. Further research is warranted to validate the effectiveness of this off-label approach, define optimal dosing regimens to meet individual patient needs, and evaluate the cost–benefit implications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 7","pages":"1232-1236"},"PeriodicalIF":4.2,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise and diet effects on delay discounting and related neurobiology in adults with overweight or obesity: A randomized trial","authors":"Kelly T. Cosgrove,&nbsp;Marc-Andre Cornier,&nbsp;Maureen McHugo,&nbsp;Edward L. Melanson,&nbsp;Allison Hild,&nbsp;Eugene Kronberg,&nbsp;Elizabeth A. Thomas,&nbsp;Keith Dodd,&nbsp;Eric D. Claus,&nbsp;Jason R. Tregellas,&nbsp;Kristina T. Legget","doi":"10.1002/oby.24307","DOIUrl":"10.1002/oby.24307","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study compared effects of exercise training and diet on impulsivity-related behaviors as measured by delay discounting and related neurobiology in adults with overweight or obesity. We hypothesized that exercise versus diet would be associated with reduced delay discounting propensity (<i>k</i>) and increased response in brain regions involved in cognitive control (medial prefrontal cortex, anterior cingulate cortex, and bilateral anterior insulae).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants (<i>N</i> = 40) were randomized to 12 weeks of exercise training or diet intervention. At baseline and postintervention, they completed a delay discounting task during functional magnetic resonance imaging (fMRI) in fasted and fed (post-meal) conditions. Linear mixed effects models assessed fasted–fed intervention effects on <i>k</i> and brain response in regions of interest. Exploratory analyses assessed whole-brain, satiety-state–specific, and reaction time effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Across groups, <i>k</i> and reaction time during delay discounting decreased and weight decreased from baseline to postintervention (<i>p</i> values ≤ 0.010). In exploratory fed-state whole-brain analyses, a group × session effect was observed in the right dorsolateral prefrontal cortex (<i>p</i> &lt; 0.005), driven by exercise-associated changes. A similar group × session interaction effect was observed in the anterior cingulate cortex (<i>p</i> = 0.006), also driven by reductions in fed-state response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Both interventions altered delay discounting behaviors. Exercise training was associated with reduced fed-state engagement of brain regions involved in self-referential processing and regulation during decision-making.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 7","pages":"1263-1274"},"PeriodicalIF":4.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A GLP1R gene variant and sex influence the response to semaglutide treatment in patients with severe obesity","authors":"Aurélie Phan,&nbsp;Claire Carette,&nbsp;Céline Narjoz,&nbsp;Claire Rives-Lange,&nbsp;Nathalie Rassy,&nbsp;Sebastien Czernichow,&nbsp;Nicolas Pallet","doi":"10.1002/oby.24300","DOIUrl":"10.1002/oby.24300","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study is to identify whether the glucagon-like peptide-1 receptor (<i>GLP1R</i>) gene variant rs6923761G→A has an influence on semaglutide response in individuals with severe obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>From March 2023 to July 2024, we prospectively genotyped 112 patients treated with semaglutide 2.4 mg weekly. All patients had been treated over 4 months for grade 3 obesity (BMI ≥ 40 kg/m²).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The frequency of the rs6923761 AA variant was 9 out of 112 patients (8%), GA was 42 out of 112 (37.5%), and GG was 61 out of 112 (54.5%). The mean weight loss kinetics was 1.64% (SD 0.78%) per month in homozygotes of variant A in comparison with a mean weight loss of 1.04% (SD 0.79%) per month in carriers of at least one G variant (<i>p</i> = 0.03). Multivariate analysis demonstrated that rs6923761G→A and sex were independent predictors of weight loss. The rate of weight loss in women homozygous for the A allele was more than double that observed in men carrying the G allele: mean (SD) 1.89% (0.75%) per month versus 0.7% (0.7%) per month (<i>p</i> = 0.0009). No woman homozygous for the A allele was a nonresponder, compared with 56% (21 out of 37) of the men carrying the G allele.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The rs6923761G→A gene variant and sex profoundly affect weight loss in response to semaglutide in patients with severe obesity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 7","pages":"1237-1242"},"PeriodicalIF":4.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial–temporal analysis and spatial drivers of childhood obesity in China from 1985 to 2019","authors":"Jiajia Dang,&nbsp;Yihang Zhang,&nbsp;Yunfei Liu,&nbsp;Di Shi,&nbsp;Shan Cai,&nbsp;Ziyue Chen,&nbsp;Jiaxin Li,&nbsp;Tianyu Huang,&nbsp;Ziyue Sun,&nbsp;Xi Li,&nbsp;Jun Ma,&nbsp;Zilong Zhang,&nbsp;Yi Song","doi":"10.1002/oby.24303","DOIUrl":"10.1002/oby.24303","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We characterized the spatial–temporal trends of obesity among Chinese children and adolescents from 1985 to 2019 and examined the impact of social determinants of health (SDOH) patterns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using data from the Chinese National Survey on Students' Constitution and Health (CNSSCH) conducted between 1985 and 2019, featuring seven cross-sectional surveys, we employed spatial–temporal analysis methods and collected 23 obesity-related variables to identify SDOH patterns. A general linear regression model investigated associations between SDOH patterns and obesity prevalence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Obesity prevalence rose from 0.1% to 8.1%. Northern regions formed a high-obesity cluster, whereas Southern regions were low-obesity clusters. The following four SDOH patterns emerged: Western Resource-Limited Frontier, Coastal-Central Development Belt, Inland Agricultural Heartland, and Metropolitan Resource-Rich Hubs. Prevalence was 5.7%, 5.8%, 10.2%, and 11.3% for Patterns 1 through 4, respectively. Compared with Pattern 2, Patterns 3 and 4 showed higher obesity risks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Childhood obesity prevalence in China increased with regional disparities from 1985 to 2019, with higher prevalence in the North and lower prevalence in the South. SDOH patterns were linked to spatial clusters, suggesting that regions characterized by advanced urbanization, abundant resources (Pattern 4), and a dietary profile heavy in carbohydrates and low in protein (Pattern 3) potentially contributed to increased obesity risk.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 7","pages":"1344-1354"},"PeriodicalIF":4.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generational differences in associations between health conditions in young women and BMI categories","authors":"Annette J. Dobson,&nbsp;Chen Liang,&nbsp;Gita D. Mishra","doi":"10.1002/oby.24304","DOIUrl":"10.1002/oby.24304","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to investigate whether the associations between BMI categories and the age-specific prevalence of health conditions common in young women differed across generations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were from the Australian Longitudinal Study on Women's Health for participants born between 1973 and 1978 or 1989 and 1995 and recruited in 1996 and 2013, respectively. Women were included if they reported their weight and height at waves conducted when they were aged 18 to 23, 22 to 27, and 25 to 30 years. Outcomes were self-rated health, the prevalence of common conditions, menstrual symptoms, and pregnancy complications. Odds ratios (ORs) were estimated using logistic regression models with generalized estimating equations to account for repeated measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For fair or poor self-rated health, the ORs were higher for women in the underweight range (OR 1.51, 95% CI: 1.30–1.74) or the overweight range (OR 1.47, 95% CI: 1.34–1.60), were highest for women with obesity (OR 3.04, 95% CI: 2.76–3.35) compared with women with normal weight, and were higher for the more recent cohort (OR 1.50, 95% CI: 1.38–1.63). This same pattern was apparent for all outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The health impacts of increasing BMI are not lessened in more recent generations. This evidence can be used to promote the benefits of normal BMI for young women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 7","pages":"1386-1394"},"PeriodicalIF":4.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle behavioral weight-loss treatment for binge-eating disorder in patients with obesity: where's the harm?","authors":"Sydney Yurkow,&nbsp;Valentina Ivezaj,&nbsp;Carlos M. Grilo","doi":"10.1002/oby.24289","DOIUrl":"10.1002/oby.24289","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Although recent rigorous trials have demonstrated effectiveness of behaviorally based weight-loss treatment (BBWLT) for binge-eating disorder (BED) with coexisting obesity, concerns have been raised that such interventions are contraindicated because they might trigger or exacerbate eating disorder (ED) psychopathology. This secondary analysis of a BBWLT trial examined heterogeneity of outcomes to identify the frequency that individuals experienced increased symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One hundred ninety-one participants with BED and obesity in a 6-month BBWLT trial were assessed for binge eating, ED psychopathology, and weight at baseline, at posttreatment, and at a 12-month follow-up after treatment (i.e., 18 months after baseline). Changes were examined at the individual level to identify cases of any increased features.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At posttreatment, 95.3% (<i>n</i> = 162) of participants reported decreased binge-eating frequency, and 87.6% (<i>n</i> = 149) reported decreased ED psychopathology scores. At the 12-month follow-up, 97.1% (<i>n</i> = 135) reported decreased binge-eating frequency, and 93.0% (<i>n</i> = 120) reported decreased ED psychopathology scores. Inspection of the few instances of any increases revealed mostly small magnitudes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Frequency of cases with any increased symptoms of binge eating and/or ED psychopathology was quite low at posttreatment and at 1 year after ending BBWLT for BED and obesity. These participant-level findings add important clinical context regarding overall improvements with BBWLT for BED with obesity (large effect sizes) and challenge concerns that BBWLT exacerbates ED psychopathology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":"1058-1066"},"PeriodicalIF":4.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24289","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational weight gain, cardiometabolic health, and long-term weight retention at 17 years post delivery","authors":"Marcela R. Abrego,&nbsp;Andrew G. Rundle,&nbsp;Saralyn F. Foster,&nbsp;Daniel A. Powers,&nbsp;Lori A. Hoepner,&nbsp;Eliza W. Kinsey,&nbsp;Frederica P. Perera,&nbsp;Elizabeth M. Widen","doi":"10.1002/oby.24276","DOIUrl":"10.1002/oby.24276","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>High gestational weight gain (GWG) is positively associated with acute postpartum adiposity, long-term postpartum weight retention (LPPWR), and later cardiometabolic health, but whether associations persist into midlife remains unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Among Black and Dominican women from a prospective cohort (<i>N</i> = 210), GWG adherence to 2009 Institute of Medicine (IOM) guidelines and restricted cubic spline GWG <i>z</i> scores were calculated. At 17 years post delivery, weight, height, waist circumference (WC), systolic and diastolic blood pressure, fat mass (FM), and fat-free mass were measured. Linear and logistic regression estimated associations between GWG and long-term postpartum outcomes, adjusting for covariates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over one-half (60%) of participants had GWG above IOM guidelines. At 17 years, mean (SD) BMI was 31.2 (6.7) kg/m². GWG above IOM guidelines was positively associated with 17-year FM (β = 5.11 kg; 95% CI: 2.35–7.88), WC (β = 4.95 cm; 95% CI: 2.07–7.83), and LPPWR from prepregnancy to 17 years (β = 6.10 kg; 95% CI: 2.46–9.75), but not with blood pressure. Positive associations were also observed between GWG <i>z</i> scores and body fat percentage, FM, fat-free mass, WC, and LPPWR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>As women age into midlife, high GWG continues to be associated with higher adiposity, as well as weight gain more than 6 kg above prepregnancy weight, compared with those who gain within or below IOM guidelines.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":"1145-1153"},"PeriodicalIF":4.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerometer-derived “weekend warrior” and regularly active physical activity and incident diabetes","authors":"Lubi Lei,&nbsp;Jingkuo Li,&nbsp;Wei Wang,&nbsp;Lihua Zhang,&nbsp;Xuyang Meng,&nbsp;Chenxi Xia,&nbsp;Yi Li,&nbsp;Yejing Zhao,&nbsp;Xin Yuan,&nbsp;Xiang Wang,&nbsp;Fang Wang","doi":"10.1002/oby.24278","DOIUrl":"10.1002/oby.24278","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We aim to investigate associations between moderate-to-vigorous physical activity (MVPA) patterns and the risk of diabetes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective cohort study was based on 85,934 participants in the UK Biobank. We incorporated two thresholds of MVPA, including the guideline-based threshold (≥150 min/week) and the sample median (≥230.4 min/week). Individuals were classified as weekend warrior (WW, i.e., at or above the MVPA threshold and ≥50% of total MVPA over 1–2 days), regularly active (RA, i.e., at or above the MVPA threshold but not WW), and inactive (i.e., below the MVPA threshold). We employed Cox proportional hazards regression models to examine the associations of MVPA patterns with the risk of developing diabetes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Stratified by MVPA patterns at ≥150 min/week of MVPA, 43.7% (<i>n</i> = 37,594) of participants were classified as having the WW pattern. Compared with the inactive pattern, WW (hazard ratio [HR]: 0.76, 95% CI: 0.69–0.84) and RA (HR: 0.64, 95% CI: 0.56–0.73) patterns were associated with a lower risk of diabetes. Our findings remained consistent by employing the median threshold.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The WW pattern was associated with a similarly lower risk of diabetes as the RA pattern versus the physically inactive pattern.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":"1154-1164"},"PeriodicalIF":4.2,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24278","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging shared variation among traits for the discovery of genetic variants in complex phenotypes such as obesity","authors":"Rodrigo Fernández-Verdejo,&nbsp;David Hughes,&nbsp;Eric Ravussin","doi":"10.1002/oby.24313","DOIUrl":"10.1002/oby.24313","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":"1025-1026"},"PeriodicalIF":4.2,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}