在全身房间热量计中评估高脂肪膳食代谢灵活性的新方法的验证。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2025-03-06 DOI:10.1002/oby.24245

David H. McDougal, Guillermo Sanchez-Delgado, Emily W. Flanagan, Kara L. Marlatt, Joshua R. Sparks, Shengping Yang, Leanne M. Redman, Eric Ravussin

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引用次数: 0

摘要

目的：西方高脂肪饮食的代谢不灵活性可能是肥胖流行的原因之一。然而，目前还缺乏评估高脂肪膳食代谢灵活性（MetFlex）的有效方法。本研究的目的是评估一种确定MetFlex对高脂肪膳食的新方法的可靠性，并将其与测量MetFlex对高碳水化合物负荷的金标准进行比较。方法：我们的研究纳入了8名健康成人，其中包括以下两项MetFlex评估：1)MetFlex对脂肪的影响，通过在代谢室中过夜，间隔5至7天；2) Metflex对碳水化合物的影响，通过两步高胰岛素-血糖钳夹在5天后测量。结果：参与者主要是白人和男性，平均（SD）年龄为29.4（6.3）岁，BMI为25.4 (4.1)kg/m2。MetFlex对脂肪表现出令人满意的重测信度（类内相关系数>.70），但与钳夹期间测量的MetFlex没有相关性。结论：高脂肪晚餐后一夜之间底物氧化的变化代表了MetFlex的一个独特方面，这是使用更传统的方法无法捕获的。我们的研究结果支持前瞻性研究，以确定这些参数是否可以预测肥胖或代谢功能障碍的发展。

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Validation of a novel approach to assess metabolic flexibility to a high-fat meal in a whole-body room calorimeter

Objective

Metabolic inflexibility to Western high-fat diets may contribute to the obesity epidemic. However, validated methods for assessing metabolic flexibility (MetFlex) to high-fat meals are currently lacking. The purpose of this study was to evaluate the reliability of a novel approach for determining MetFlex to a high-fat meal and to compare it with the gold standard for measuring MetFlex to high-carbohydrate loads.

Methods

Eight healthy adults were enrolled in our study, which consisted of the following two assessments of MetFlex: 1) MetFlex to fat, via two overnight stays in a metabolic chamber separated by 5 to 7 days; and 2) Metflex to carbohydrates, via a two-step hyperinsulinemic-euglycemic clamp measured >5 days later.

Results

Participants were predominantly White and male, with mean (SD) age of 29.4 (6.3) years and BMI of 25.4 (4.1) kg/m². MetFlex to fat displayed satisfactory test–retest reliability (intraclass correlation coefficient > 0.70) for several outcomes but showed no correlation to MetFlex measured during the clamp.

Conclusions

Overnight changes in substrate oxidation following a high-fat dinner meal represent a unique aspect of MetFlex that cannot be captured using more conventional methods. Our findings warrant prospective studies to determine whether these parameters are predictive of the development of obesity or metabolic dysfunction.

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.