Neil Thivalapill, Todd M. Jenkins, Thomas H. Inge, Changchun Xie, Anita P. Courcoulas, Carroll M. Harmon, Michael A. Helmrath, Stephanie Sisley, Marc P. Michalsky, Justin R. Ryder, Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) consortium
{"title":"青少年减肥手术后6年内功能活动能力和疼痛得到改善。","authors":"Neil Thivalapill, Todd M. Jenkins, Thomas H. Inge, Changchun Xie, Anita P. Courcoulas, Carroll M. Harmon, Michael A. Helmrath, Stephanie Sisley, Marc P. Michalsky, Justin R. Ryder, Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) consortium","doi":"10.1002/oby.24285","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>The long-term durability of improvements in functional mobility and musculoskeletal pain for adolescents after metabolic and bariatric surgery (MBS) is unknown.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We used the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study to determine the change in mobility and pain among adolescents who underwent MBS. From standardized 400-m walk tests, we analyzed walk time, heart rate (HR) parameters, and musculoskeletal pain.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The mean walk time improved from 383 s (95% CI: 368–399) prior to surgery to 351 s (95% CI: 330–372) by 6 years. The mean resting HR was 90 beats per minute (bpm; 95% CI: 87–93) preoperatively and decreased to 80 bpm (95% CI: 76–84) by 6 years. The risk of any musculoskeletal pain decreased from 37.2% (95% CI: 25.5%–48.9%) to 11.0% (95% CI: 4.3%–17.6%) by 6 years. Mediation analysis revealed that the effect of time since surgery on walk time, resting HR, and HR recovery occurred through a weight-dependent mechanism. For posttest HR and HR difference, there was both a significant weight-dependent and weight-independent mechanism. The effect of surgery on the risk of musculoskeletal pain occurred through a weight-independent mechanism.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Adolescents who underwent MBS experienced significant, durable improvement in mobility and pain, despite weight regain. Our models suggest that improvements may occur through a weight-independent mechanism.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 6","pages":"1126-1135"},"PeriodicalIF":4.2000,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24285","citationCount":"0","resultStr":"{\"title\":\"Functional mobility and pain are improved for 6 years after adolescent bariatric surgery\",\"authors\":\"Neil Thivalapill, Todd M. Jenkins, Thomas H. Inge, Changchun Xie, Anita P. Courcoulas, Carroll M. Harmon, Michael A. Helmrath, Stephanie Sisley, Marc P. Michalsky, Justin R. Ryder, Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) consortium\",\"doi\":\"10.1002/oby.24285\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>The long-term durability of improvements in functional mobility and musculoskeletal pain for adolescents after metabolic and bariatric surgery (MBS) is unknown.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We used the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study to determine the change in mobility and pain among adolescents who underwent MBS. From standardized 400-m walk tests, we analyzed walk time, heart rate (HR) parameters, and musculoskeletal pain.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The mean walk time improved from 383 s (95% CI: 368–399) prior to surgery to 351 s (95% CI: 330–372) by 6 years. The mean resting HR was 90 beats per minute (bpm; 95% CI: 87–93) preoperatively and decreased to 80 bpm (95% CI: 76–84) by 6 years. The risk of any musculoskeletal pain decreased from 37.2% (95% CI: 25.5%–48.9%) to 11.0% (95% CI: 4.3%–17.6%) by 6 years. Mediation analysis revealed that the effect of time since surgery on walk time, resting HR, and HR recovery occurred through a weight-dependent mechanism. For posttest HR and HR difference, there was both a significant weight-dependent and weight-independent mechanism. The effect of surgery on the risk of musculoskeletal pain occurred through a weight-independent mechanism.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Adolescents who underwent MBS experienced significant, durable improvement in mobility and pain, despite weight regain. Our models suggest that improvements may occur through a weight-independent mechanism.</p>\\n </section>\\n </div>\",\"PeriodicalId\":215,\"journal\":{\"name\":\"Obesity\",\"volume\":\"33 6\",\"pages\":\"1126-1135\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-04-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24285\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/oby.24285\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24285","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Functional mobility and pain are improved for 6 years after adolescent bariatric surgery
Objective
The long-term durability of improvements in functional mobility and musculoskeletal pain for adolescents after metabolic and bariatric surgery (MBS) is unknown.
Methods
We used the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study to determine the change in mobility and pain among adolescents who underwent MBS. From standardized 400-m walk tests, we analyzed walk time, heart rate (HR) parameters, and musculoskeletal pain.
Results
The mean walk time improved from 383 s (95% CI: 368–399) prior to surgery to 351 s (95% CI: 330–372) by 6 years. The mean resting HR was 90 beats per minute (bpm; 95% CI: 87–93) preoperatively and decreased to 80 bpm (95% CI: 76–84) by 6 years. The risk of any musculoskeletal pain decreased from 37.2% (95% CI: 25.5%–48.9%) to 11.0% (95% CI: 4.3%–17.6%) by 6 years. Mediation analysis revealed that the effect of time since surgery on walk time, resting HR, and HR recovery occurred through a weight-dependent mechanism. For posttest HR and HR difference, there was both a significant weight-dependent and weight-independent mechanism. The effect of surgery on the risk of musculoskeletal pain occurred through a weight-independent mechanism.
Conclusions
Adolescents who underwent MBS experienced significant, durable improvement in mobility and pain, despite weight regain. Our models suggest that improvements may occur through a weight-independent mechanism.
期刊介绍：
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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