Adiposity associations with risk of colorectal cancer: a systematic review

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2025-07-13 DOI:10.1002/oby.24314

Shelby G. Ziller, Carrie S. Standage-Beier, Uzoamaka E. Okwor, D. Jean McClelland, Bahar Bakhshi, Dawn K. Coletta, Jennifer W. Bea

{"title":"Adiposity associations with risk of colorectal cancer: a systematic review","authors":"Shelby G. Ziller, Carrie S. Standage-Beier, Uzoamaka E. Okwor, D. Jean McClelland, Bahar Bakhshi, Dawn K. Coletta, Jennifer W. Bea","doi":"10.1002/oby.24314","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>This systematic review evaluates the relationship between adiposity and incident colorectal cancer (CRC) risk.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>MEDLINE, Scopus, Embase, CINAHL, and CENTRAL were searched for articles that met the following criteria: 1) assessed adiposity measures; 2) included incident data for any diagnosed malignant stage of CRC, colon cancer, or rectal cancer; and 3) studied adults aged older than 18 years. Articles were assessed for bias using the National Institutes of Health study quality assessment tools.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Fifteen articles across ten studies met the inclusion criteria. Three significant associations were positive, one was negative, and eleven were nonsignificant and positive. Measures varied based on the tool, and these four tools were used to gather body composition measures: bioelectrical impedance, computerized tomography, dual-energy x-ray absorptiometry, and ultrasound. The most used were total body fat mass and percent fat, along with abdominal visceral and subcutaneous adipose tissues. Overall, higher levels of adipose were positively associated with an increased risk of CRC. The strength of associations and significance varied by body composition variable, measurement technique, tumor location, and sex.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Standardization is needed to better elucidate the relation between CRC and adiposity to allow for comparisons across papers. Additionally, a balance among precision, accessibility, and cost of measurements must be struck.</p>\n \n <div>\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </div>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 8","pages":"1416-1431"},"PeriodicalIF":4.2000,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24314","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

This systematic review evaluates the relationship between adiposity and incident colorectal cancer (CRC) risk.

Methods

MEDLINE, Scopus, Embase, CINAHL, and CENTRAL were searched for articles that met the following criteria: 1) assessed adiposity measures; 2) included incident data for any diagnosed malignant stage of CRC, colon cancer, or rectal cancer; and 3) studied adults aged older than 18 years. Articles were assessed for bias using the National Institutes of Health study quality assessment tools.

Results

Fifteen articles across ten studies met the inclusion criteria. Three significant associations were positive, one was negative, and eleven were nonsignificant and positive. Measures varied based on the tool, and these four tools were used to gather body composition measures: bioelectrical impedance, computerized tomography, dual-energy x-ray absorptiometry, and ultrasound. The most used were total body fat mass and percent fat, along with abdominal visceral and subcutaneous adipose tissues. Overall, higher levels of adipose were positively associated with an increased risk of CRC. The strength of associations and significance varied by body composition variable, measurement technique, tumor location, and sex.

Conclusions

Standardization is needed to better elucidate the relation between CRC and adiposity to allow for comparisons across papers. Additionally, a balance among precision, accessibility, and cost of measurements must be struck.

Abstract Image

查看原文本刊更多论文

肥胖与结直肠癌风险的关系：一项系统综述

目的：本系统综述评价肥胖与结直肠癌（CRC）发病风险的关系。方法：检索MEDLINE、Scopus、Embase、CINAHL和CENTRAL等符合以下标准的文章：1)评估肥胖措施；2)纳入任何诊断为恶性阶段的结直肠癌、结肠癌或直肠癌的事件数据；3)研究年龄在18岁以上的成年人。使用美国国立卫生研究院研究质量评估工具对文章进行偏倚评估。结果：10项研究中的15篇文章符合纳入标准。3个显著相关为正相关，1个显著相关为负相关，11个显著相关为正相关。测量方法因工具的不同而不同，这四种工具用于收集身体成分测量：生物电阻抗、计算机断层扫描、双能x线吸收仪和超声波。最常用的是全身脂肪质量和脂肪百分比，以及腹部内脏和皮下脂肪组织。总体而言，较高的脂肪水平与CRC风险增加呈正相关。相关性的强度和显著性因身体组成变量、测量技术、肿瘤位置和性别而异。结论：需要标准化来更好地阐明结直肠癌和肥胖之间的关系，以便在论文之间进行比较。此外，必须在测量的精度、可访问性和成本之间取得平衡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.