Obesity最新文献

{"title":"Planning laws as part of a systems approach are needed to improve children's health and reduce inequalities","authors":"Shu Wen Ng, Christina Vogel","doi":"10.1002/oby.24165","DOIUrl":"10.1002/oby.24165","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 12","pages":"2221-2222"},"PeriodicalIF":4.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico and functional analysis identifies key gene networks and novel gene candidates in obesity-linked human visceral fat","authors":"Lijin Wang,&nbsp;Pratap Veerabrahma Seshachalam,&nbsp;Ruiming Chua,&nbsp;Hongwen Zhou,&nbsp;Sun Lei,&nbsp;Sujoy Ghosh","doi":"10.1002/oby.24161","DOIUrl":"10.1002/oby.24161","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Visceral adiposity is associated with increased proinflammatory activity, insulin resistance, diabetes risk, and mortality rate. Numerous individual genes have been associated with obesity, but studies investigating gene regulatory networks in human visceral obesity have been lacking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed gene regulatory networks in human visceral adipose tissue (VAT) from 48 and 11 Chinese patients with and without obesity, respectively, using gene coexpression and gene regulatory network construction from RNA-sequencing data. We also conducted RNA interference-based functional tests on selected genes for effects on adipocyte differentiation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A scale-free gene coexpression network was constructed from 360 differentially expressed genes between VAT samples from patients with and without obesity (absolute log fold change &gt; 1, false discovery rate [FDR] &lt; 0.05), with edge probability &gt; 0.8. Gene regulatory network analysis identified candidate transcription factors associated with differentially expressed genes. A total of 15 subnetworks (communities) displayed altered connectivity patterns between obesity and nonobesity networks. Genes in proinflammatory pathways showed increased network connectivity in VAT samples with obesity, whereas the oxidative phosphorylation pathway displayed reduced connectivity (enrichment FDR &lt; 0.05). Functional screening via RNA interference identified genes such as <i>SOX30</i>, <i>SIRPB1</i>, and <i>OSBPL3</i> as potential network-derived candidates influencing adipocyte differentiation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This approach highlights the network architecture in human obesity, identifies novel candidate genes, and generates new hypotheses regarding network-assisted gene regulation in VAT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 11","pages":"1998-2011"},"PeriodicalIF":4.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11548800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic mobility, metabolic health, and diet: mediation via subjective socioeconomic status","authors":"Julia M. P. Bittner,&nbsp;Stephen E. Gilman,&nbsp;Zhen Chen,&nbsp;Neil J. Perkins,&nbsp;Bobby K. Cheon","doi":"10.1002/oby.24148","DOIUrl":"10.1002/oby.24148","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Socioeconomic mobility, i.e., changing socioeconomic status (SES) between adolescence and adulthood, may impact health through changing resources, social status, and health-related behaviors. This analysis examined whether subjective SES contributes to associations of mobility with metabolic health (BMI and metabolic syndrome) and unhealthy diets (fast-food consumption and sugar-sweetened beverage [SSB] consumption).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>National Longitudinal Study of Adolescent to Adult Health data were used (<i>n</i> = 4132). Mobility was defined as the difference between adolescent (collected 1994–1995, ages 11–19 years) and adult (collected 2016–2018, ages 33–43 years) SES. Linear and logistic regressions examined associations of mobility with metabolic and dietary outcomes and mediation by subjective SES.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Substantial upward mobility was associated with lower risk of high SSB consumption compared with stable disadvantaged SES (risk difference: −0.10 [95% CI: −0.16 to −0.041]). Subjective SES mediated associations of upward, but not downward, mobility with risks of developing metabolic syndrome, high fast-food consumption, and high SSB consumption; upward mobility was associated with higher subjective SES and lower risks of poor metabolic and dietary outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The finding that subjective SES contributed to associations between upward mobility and better health may inform development of interventions designed to promote healthier diets and reduce socioeconomic disparities in metabolic health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 11","pages":"2035-2044"},"PeriodicalIF":4.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based clustering identifies obesity subgroups with differential multi-omics profiles and metabolic patterns","authors":"Mohammad Y. Anwar,&nbsp;Heather Highland,&nbsp;Victoria Lynn Buchanan,&nbsp;Mariaelisa Graff,&nbsp;Kristin Young,&nbsp;Kent D. Taylor,&nbsp;Russell P. Tracy,&nbsp;Peter Durda,&nbsp;Yongmei Liu,&nbsp;Craig W. Johnson,&nbsp;Francois Aguet,&nbsp;Kristin G. Ardlie,&nbsp;Robert E. Gerszten,&nbsp;Clary B. Clish,&nbsp;Leslie A. Lange,&nbsp;Jingzhong Ding,&nbsp;Mark O. Goodarzi,&nbsp;Yii-Der Ida Chen,&nbsp;Gina M. Peloso,&nbsp;Xiuqing Guo,&nbsp;Maggie A. Stanislawski,&nbsp;Jerome I. Rotter,&nbsp;Stephen S. Rich,&nbsp;Anne E. Justice,&nbsp;Ching-ti Liu,&nbsp;Kari North","doi":"10.1002/oby.24137","DOIUrl":"10.1002/oby.24137","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Individuals living with obesity are differentially susceptible to cardiometabolic diseases. We hypothesized that an integrative multi-omics approach might improve identification of subgroups of individuals with obesity who have distinct cardiometabolic disease patterns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed machine learning-based, integrative unsupervised clustering to identify proteomics- and metabolomics-defined subpopulations of individuals living with obesity (BMI ≥ 30 kg/m²), leveraging data from 243 individuals in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Omics that contributed to the observed clusters were functionally characterized. We performed multivariate regression to assess whether the individuals in each cluster demonstrated differential patterns of cardiometabolic traits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified two distinct clusters (iCluster1 and 2). iCluster2 had significantly higher average BMI values, fasting blood glucose, and inflammation. iCluster1 was associated with higher levels of total cholesterol and high-density lipoprotein cholesterol. Pathways mediating cell growth, lipogenesis, and energy expenditures were positively associated with iCluster1. Inflammatory response and insulin resistance pathways were positively associated with iCluster2.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although the two identified clusters may represent progressive obesity-related pathologic processes measured at different stages, other mechanisms in combination could also underpin the identified clusters given no significant age difference between the comparative groups. For instance, clusters may reflect differences in dietary/behavioral patterns or differential rates of metabolic damage.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 11","pages":"2024-2034"},"PeriodicalIF":4.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of higher offspring early-childhood weight gain with prepregnancy metabolic and bariatric surgery","authors":"Maya-Jean Hilaire,&nbsp;Annelise Babcock,&nbsp;Glenn White,&nbsp;Cynthia F. Masson,&nbsp;Rany M. Salem,&nbsp;Uma M. Reddy,&nbsp;Dympna Gallagher,&nbsp;Charles A. LeDuc,&nbsp;Vidhu V. Thaker","doi":"10.1002/oby.24166","DOIUrl":"10.1002/oby.24166","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to assess maternal gestational outcomes and offspring growth trajectories following prepregnancy metabolic and bariatric surgery (MBS) compared with non-MBS controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Single-center deliveries between January 2020 and March 2023 with prepregnancy Roux-en-Y gastric bypass (herein referred to as “bypass”), sleeve gastrectomy (herein referred to as “sleeve”), and non-MBS controls were included. Offspring growth trajectories were compared with the World Health Organization child growth standards. Linear mixed models assessed MBS-bypass and MBS-sleeve offspring weight, length, and BMI trajectories with a prepregnancy BMI 27 to 37 kg/m² and propensity score-matched controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 440 participants with prepregnancy MBS (MBS-bypass, 185; MBS-sleeve, 225; 76% Hispanic/Latino) and 13,434 non-MBS controls. Gestational weight gain and gestational diabetes mellitus were similar, whereas hypertensive disorders of pregnancy were more common after MBS. The post-MBS offspring had lower birth weight but higher weight gain at 24 months (sleeve, +1.4 kg [95% CI: 1.0–1.9]; bypass, +0.5–0.7 kg [95% CI: 0.0–1.2]) compared with non-MBS groups. Male children had higher weight gain than females. The post-MBS-sleeve but not the post-MBS-bypass offspring had higher BMI <i>z</i> scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The higher early-life weight gain and sex differences in the post-MBS-sleeve group compared with the post-MBS-bypass group provide a window toward elucidating pathways to mitigate intergenerational metabolic risk transfer.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 11","pages":"2012-2023"},"PeriodicalIF":4.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unpacking the (more accepted) role of the dental team in obesity","authors":"Zanab Malik,&nbsp;Kathryn Williams,&nbsp;Deborah Cockrell,&nbsp;Clare E. Collins","doi":"10.1002/oby.24171","DOIUrl":"10.1002/oby.24171","url":null,"abstract":"&lt;p&gt;The role of dental professionals in health care prevention and management has received recent attention in line with increasing evidence linking systemic and oral diseases [&lt;span&gt;(1)&lt;/span&gt;]. Why is this so? Dental professionals are well placed to provide general health messages and make referrals to relevant health care professionals given the significant number of people who are accessing primary dental services. It could be argued that the dental profession has been less-often considered in efforts for obesity prevention and treatment compared with other public health priorities despite the “globesity” crisis referenced by the World Health Organization [&lt;span&gt;(2)&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Fundamental to the dental professional's role in supporting obesity treatment is whether patients will agree with such a strategy. Without patient “buy-in,” the success of any additional efforts can only be minimal. The study by Large et al. [&lt;span&gt;(3)&lt;/span&gt;] in this issue of &lt;i&gt;Obesity&lt;/i&gt; helps to dispel the common misconception that the public may not accept a dental team taking an active role in weight screening of patients. A key study finding was that the majority, i.e., 60%, of the 3580 participants in this UK population study reported that they would be comfortable with height and weight measurements being taken at their dental appointment [&lt;span&gt;(3)&lt;/span&gt;]. This would facilitate routine screening of obesity as part of the patient's dental visit and, potentially, the subsequent offer of referral to weight-based interventions initiated by the dental team. However, this finding simultaneously brings awareness to the remaining 40% of study participants who reported not feeling comfortable with these measurements being taken at their dental visit. This highlights the importance of the dental team in obtaining consent before any measurements are taken, referencing the purpose for which they will be used, and ensuring that they are maintained confidentially as part of the clinical record. For those who decline, this must be equally respected and understood given the lived experiences of bias and discrimination in health care settings for many individuals living with obesity. As discussed in the paper, dental professionals have cited fear of offending patients as a barrier to asking about weight, thereby reflecting possible discomfort with this task. It is therefore prudent that education of the dental team includes practical training around nonstigmatizing communication approaches to ensure that they are not only respectful, compassionate, and empathetic but that they can engage with confidence. The implementation of pre-appointment screening, possibly as part of routine medical history questionnaires, and allowing patients to “opt-out” of such discussions and measurements may minimize negative experiences or discomfort for both patients and the dental team.&lt;/p&gt;&lt;p&gt;In dental settings, weight-based conversations may be additionally challenging with adults living wi","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 12","pages":"2223-2224"},"PeriodicalIF":4.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk related to gestational weight loss among individuals with obesity: a population-based cohort study","authors":"Yanfang Guo,&nbsp;Sara C. S. Souza,&nbsp;Liam Bruce,&nbsp;Rong Luo,&nbsp;Darine El-Chaâr,&nbsp;Laura M. Gaudet,&nbsp;Katherine Muldoon,&nbsp;Steven Hawken,&nbsp;Sandra I. Dunn,&nbsp;Ruth Rennicks White,&nbsp;Alysha L. J. Dingwall-Harvey,&nbsp;Mark C. Walker,&nbsp;Shi Wu Wen,&nbsp;Daniel J. Corsi","doi":"10.1002/oby.24143","DOIUrl":"10.1002/oby.24143","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>There is no clear evidence on the risk of gestational weight loss (GWL) for individuals with obesity. Our study aimed to assess the association between GWL and adverse perinatal outcomes among individuals with obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This population-based retrospective cohort study examined individuals with prepregnancy BMI ≥ 30 kg/m² who had a singleton pregnancy, using Ontario, Canada, birth registry data from 2012 to 2020. The primary outcome was a composite of adverse outcomes, including perinatal death and neonatal morbidity. The association between GWL and risk of adverse perinatal outcomes was estimated using generalized estimating equation models and restricted cubic spline regression analysis. Stratified analysis was conducted by obesity class.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 157,205 individuals with obesity, 6.1% experienced GWL. Compared with adequate gestational weight gain, GWL was associated with an increased risk of a composite of adverse perinatal outcomes (adjusted risk ratio: 1.31; 95% CI: 1.22–1.39). Similar results were observed in the stratified analysis. Restricted cubic spline regression analysis revealed that average weekly gestational weight changes displayed a nonlinear U-shaped association, with a higher risk of a composite of adverse perinatal outcomes noted in the extremities, particularly toward GWL and excessive weight gain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that GWL may increase the risk of adverse perinatal outcomes across all obesity classes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 12","pages":"2376-2387"},"PeriodicalIF":4.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One hundred-year secular trends of overweight and obesity in China: effects of age, period, and cohort","authors":"Jinchen Xie,&nbsp;Peng Nie,&nbsp;Mengzi Sun,&nbsp;Xinguang Chen,&nbsp;Tingling Xu,&nbsp;Zumin Shi,&nbsp;Chuntian Lu,&nbsp;Youfa Wang","doi":"10.1002/oby.24134","DOIUrl":"10.1002/oby.24134","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Obesity has become a major public health problem worldwide and particularly in China. This study examined the secular trend of overweight and obesity in China over the past 100 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Nationwide data from the China Health and Nutrition Survey and the Chinese General Social Survey were used. A generalized binary mixed-effects model and a weighted quantile sum model were applied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 1909 to 2021, the prevalence of overweight and obesity remained stable from 1909 to 1944, experienced a smooth increase from 1945 to 1959 followed by a decline between 1960 and 1974, continued to rise after 1975, and peaked in 2003. The prevalence of overweight (obesity) among Chinese adults increased by 2.68 (6.21) times, from 20.65% (3.10%) in 1993 to 55.33% (19.26%) in 2021, and cohorts born during the Chinese Cultural Revolution (1960–1974) exhibited the lowest risk of overweight and obesity, associated with low protein intake and high physical activity. Cohorts born during the Reform and Opening-Up period (1975–2003) showed a high risk of overweight and obesity related to favorable socioeconomic status and rapid urbanization. Persistent differences by sex and emerging differences by socioeconomic status in overweight and obesity prevalence were captured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overweight and obesity trends in China have shown a distinctive increasing–decreasing–increasing pattern over the past 100 years. These patterns exhibit unique characteristics and are influenced by discernible social forces.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 11","pages":"2186-2197"},"PeriodicalIF":4.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic characteristics of weight cycling: results from a mid-South regional comprehensive health care system","authors":"Alison Z. Swartz,&nbsp;Kathryn Wood,&nbsp;Eric Farber-Eger,&nbsp;Alexander Petty,&nbsp;Heidi J. Silver","doi":"10.1002/oby.24163","DOIUrl":"10.1002/oby.24163","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study was to determine the unique clinical and cardiometabolic risk characteristics of weight-cyclers and identify differences between weight-cyclers and individuals with other weight-change trajectories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A deidentified database of 1,428,204 Vanderbilt University Medical Center patients from 1997 to 2020 was included based on having ≥5 years of recorded weights. Patients with a history of malignant neoplasm, bariatric surgery, implausible BMI (e.g., &lt;15 or &gt;80 kg/m²), or missing documented height were excluded, yielding 83,261 participants categorized by weight trajectory, i.e., weight-stable, weight-gainer, weight-loser, or weight-cycler, based on criteria of ≥5% weight-change thresholds. Additionally, quartiles of average successive weight variability were evaluated to determine the effect of absolute differences among successive weight values.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over half (55%) of participants were weight-cyclers, 23% were weight-gainers, 12% were weight-losers, and 10% were weight-stable over 5 years. Although baseline BMI did not differ among groups, weight-cyclers were more likely to have lower high-density lipoprotein cholesterol and higher blood glucose and triglyceride levels and to have been prescribed antihypertensive, dyslipidemia, and/or antidiabetic therapies. They were also younger and more likely to be smokers. Participants with the greatest weight variability (i.e., highest quartile of average successive weight variability) had higher cardiometabolic risk scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Weight cycling was highly prevalent but yielded no meaningful overall change in body weight after 5 years. These findings support a paradigm shift in weight management in individuals with overweight/obesity toward reducing cardiometabolic risk with or without weight loss.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 11","pages":"2045-2059"},"PeriodicalIF":4.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in anthropometry, adiposity, and inflammation in Black and White women engaged in intentional weight loss","authors":"Ashley S. Felix,&nbsp;Jennifer A. Sinnott,&nbsp;Bette J. Caan,&nbsp;Shannon L. Gillespie,&nbsp;Caitlin E. Meade,&nbsp;Katherine E. Strafford,&nbsp;Casey M. Cosgrove,&nbsp;Loriana Soma,&nbsp;Sabrena Noria,&nbsp;Kristin L. Bixel,&nbsp;Ritu Salani,&nbsp;Christa I. Nagel,&nbsp;Laura M. Chambers,&nbsp;David E. Cohn,&nbsp;Adrian A. Suarez,&nbsp;Electra D. Paskett","doi":"10.1002/oby.24151","DOIUrl":"10.1002/oby.24151","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We examined associations among changes in anthropometry, regional adiposity, and inflammatory markers in Black and White women participating in intentional weight loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 104 women with BMI ≥ 25 kg/m² self-selected bariatric surgery (<i>n</i> = 66) or a diet and exercise program (<i>n</i> = 38). Anthropometric, dual-energy x-ray absorptiometry-quantified regional adiposity, and inflammatory markers (C-reactive protein [CRP], tumor necrosis factor α [TNF-α], soluble TNF receptor I [sTNFRI], sTNFRII, interleukin [IL]-6, and soluble IL-1 receptor antagonist) were measured at baseline and 6 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Weight, BMI, visceral adipose tissue, and regional (android and gynoid) adiposity declined in the bariatric surgery group. Among bariatric surgery participants, Black women experienced declines of lesser magnitude in terms of weight and BMI than White women, but changes in regional adiposity and visceral adipose tissue did not differ. In the bariatric surgery group, decreases in weight and BMI were associated with decreases in CRP and IL-6 among White women, but not Black women. Decreases in weight, BMI, and android fat were associated with increases in TNF-α, sTNFRI, and sTNFRII among Black women, but not White women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Decreases in anthropometry and adiposity were observed among Black and White bariatric surgery participants; however, associations among changes in adiposity, anthropometry, and inflammation differed by race.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 12","pages":"2398-2409"},"PeriodicalIF":4.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}