Brittney O. Baumert, Elizabeth Costello, Zhenjiang Li, Justin R. Ryder, Thomas Inge, Todd Jenkins, Stephanie Sisley, Stavra A. Xanthakos, Douglas I. Walker, Nikos Stratakis, Damaskini Valvi, Scott M. Bartell, Angela L. Slitt, Rohit Kohli, Sarah Rock, Michele A. La Merrill, Sandrah P. Eckel, Max T. Aung, Rob McConnell, David V. Conti, Lida Chatzi
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This study aimed to evaluate associations between PFAS exposure and changes in BMI, percent weight loss, and waist circumference among adolescents after bariatric surgery.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We included 186 adolescents (mean age: 17.1 years; 76.3% female; 72.0% White) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort who underwent surgery between 2007 and 2012. Anthropometric measurements were collected at baseline and 6, 12, 36, and 60 months post surgery. Presurgical plasma concentrations of seven PFAS were measured using liquid chromatography–tandem mass spectrometry. Associations were estimated using linear mixed-effects models and quantile g-computation.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Higher concentrations of PFOS, PFHxS, and PFHpS were associated with greater BMI regain, reduced percent weight loss, and increased waist circumference from 1 to 5 years post surgery. At PFOS concentrations of 1.45 to 2.94 log<sub>2</sub> ng/mL, annual BMI regain increased from 1.34 to 1.84 kg/m<sup>2</sup> (<i>p</i> = 0.0497). Mixture analyses confirmed cumulative PFAS effects, with sulfonic acids showing the strongest associations.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>PFAS exposure was associated with weight regain after bariatric surgery in adolescents, potentially undermining long-term metabolic benefits.</p>\n </section>\n \n <section>\n \n <h3> Trial Registration</h3>\n \n <p>\n ClinicalTrials.gov identifier NCT00474318</p>\n \n <div>\n \n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </div>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 10","pages":"1930-1954"},"PeriodicalIF":4.7000,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424438/pdf/","citationCount":"0","resultStr":"{\"title\":\"PFAS Exposure and Postoperative Weight Regain in Adolescents After Bariatric Surgery: Findings From the Teen-LABS Study\",\"authors\":\"Brittney O. 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This study aimed to evaluate associations between PFAS exposure and changes in BMI, percent weight loss, and waist circumference among adolescents after bariatric surgery.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We included 186 adolescents (mean age: 17.1 years; 76.3% female; 72.0% White) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort who underwent surgery between 2007 and 2012. Anthropometric measurements were collected at baseline and 6, 12, 36, and 60 months post surgery. Presurgical plasma concentrations of seven PFAS were measured using liquid chromatography–tandem mass spectrometry. Associations were estimated using linear mixed-effects models and quantile g-computation.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Higher concentrations of PFOS, PFHxS, and PFHpS were associated with greater BMI regain, reduced percent weight loss, and increased waist circumference from 1 to 5 years post surgery. At PFOS concentrations of 1.45 to 2.94 log<sub>2</sub> ng/mL, annual BMI regain increased from 1.34 to 1.84 kg/m<sup>2</sup> (<i>p</i> = 0.0497). 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PFAS Exposure and Postoperative Weight Regain in Adolescents After Bariatric Surgery: Findings From the Teen-LABS Study
Objective
Weight regain following bariatric surgery remains a clinical challenge, with limited understanding of contributing environmental factors. Per- and polyfluoroalkyl substances (PFAS), persistent chemicals linked to metabolic dysfunction, may influence long-term weight trajectories. This study aimed to evaluate associations between PFAS exposure and changes in BMI, percent weight loss, and waist circumference among adolescents after bariatric surgery.
Methods
We included 186 adolescents (mean age: 17.1 years; 76.3% female; 72.0% White) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort who underwent surgery between 2007 and 2012. Anthropometric measurements were collected at baseline and 6, 12, 36, and 60 months post surgery. Presurgical plasma concentrations of seven PFAS were measured using liquid chromatography–tandem mass spectrometry. Associations were estimated using linear mixed-effects models and quantile g-computation.
Results
Higher concentrations of PFOS, PFHxS, and PFHpS were associated with greater BMI regain, reduced percent weight loss, and increased waist circumference from 1 to 5 years post surgery. At PFOS concentrations of 1.45 to 2.94 log2 ng/mL, annual BMI regain increased from 1.34 to 1.84 kg/m2 (p = 0.0497). Mixture analyses confirmed cumulative PFAS effects, with sulfonic acids showing the strongest associations.
Conclusions
PFAS exposure was associated with weight regain after bariatric surgery in adolescents, potentially undermining long-term metabolic benefits.
期刊介绍：
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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