Acta Physiologica最新文献

{"title":"Correction to \"Beneficial effects of MGL-3196 and BAM15 combination in a mouse model of fatty liver disease\".","authors":"","doi":"10.1111/apha.14250","DOIUrl":"https://doi.org/10.1111/apha.14250","url":null,"abstract":"","PeriodicalId":107,"journal":{"name":"Acta Physiologica","volume":" ","pages":"e14250"},"PeriodicalIF":5.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral presentations","authors":"","doi":"10.1111/apha.14042","DOIUrl":"https://doi.org/10.1111/apha.14042","url":null,"abstract":"","PeriodicalId":107,"journal":{"name":"Acta Physiologica","volume":"239 S728","pages":""},"PeriodicalIF":6.3,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apha.14042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6904449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Presentations","authors":"","doi":"10.1111/apha.14044","DOIUrl":"https://doi.org/10.1111/apha.14044","url":null,"abstract":"","PeriodicalId":107,"journal":{"name":"Acta Physiologica","volume":"239 S728","pages":""},"PeriodicalIF":6.3,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apha.14044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6904459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symposia","authors":"","doi":"10.1111/apha.14043","DOIUrl":"https://doi.org/10.1111/apha.14043","url":null,"abstract":"during","PeriodicalId":107,"journal":{"name":"Acta Physiologica","volume":"239 S728","pages":""},"PeriodicalIF":6.3,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apha.14043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6904447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plenary and keynote abstracts","authors":"","doi":"10.1111/apha.14041","DOIUrl":"https://doi.org/10.1111/apha.14041","url":null,"abstract":"The increasing prevalence of obesity, prediabetes and type 2 diabetes (T2D) emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the identification of new medications to prevent conversion to T2D. Recent reports indicate that former obesity medication, 5-hydroxytryptamine (5-HT, serotonin)2C receptor (5-HT 2C R) agonist lorcaserin improves glycemic control in association with weight loss in obese patients with T2D. We examined whether lorca-serin has a direct effect on insulin sensitivity and how this effect is achieved. We clarify that lorcaserin dose-dependently improves glycemic control in a mouse model of T2D without altering body weight. Examining the mechanism of this effect, we reveal a necessary and sufficient neuro-chemical mediator of lorcaserin’s glucoregulatory effects, via activation of brain pro-opiomelanocortin (POMC) peptides. We observed that lorcaserin reduces hepatic glucose production and improves insulin sensitivity. The recent large scale clinical trial CAMELLIA-TIMI 61 revealed that lorcaserin prevented conversion to T2D and improved T2D and supports the translational relevance this medication for prediabetes and T2D treatment. Taken together, these data suggest that lorcaserin’s action within the brain represents a mechanistically novel treatment for prediabetes and T2D: findings of significance to a prevalent global disease.","PeriodicalId":107,"journal":{"name":"Acta Physiologica","volume":"239 S728","pages":""},"PeriodicalIF":6.3,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apha.14041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6869267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of cystathionine-gamma lyase dampens vasoconstriction in mouse and human intracerebral arterioles","authors":"Maria Peleli,&nbsp;Kristina S. Lyngso,&nbsp;Frantz Rom Poulsen,&nbsp;Pernille B. L. Hansen,&nbsp;Andreas Papapetropoulos,&nbsp;Jane Stubbe","doi":"10.1111/apha.14021","DOIUrl":"https://doi.org/10.1111/apha.14021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>In extracerebral vascular beds cystathionine-gamma lyase (CSE) activity plays a vasodilatory role but the role of this hydrogen sulfide (H₂S) producing enzyme in the intracerebral arterioles remain poorly understood. We hypothesized a similar function in the intracerebral arterioles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Intracerebral arterioles were isolated from wild type C57BL/6J mouse (9–12 months old) brains and from human brain biopsies. The function (contractility and secondary dilatation) of the intracerebral arterioles was tested ex vivo by pressure myography using a perfusion set-up. Reverse transcription polymerase chain reaction was used for detecting CSE expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CSE is expressed in human and mouse intracerebral arterioles. CSE inhibition with L-propargylglycine (PAG) significantly dampened the K⁺-induced vasoconstriction in intracerebral arterioles of both species (% of maximum contraction: in human control: 45.4 ± 2.7 versus PAG: 27 ± 5.2 and in mouse control: 50 ± 1.5 versus PAG: 33 ± 5.2) but did not affect the secondary dilatation. This effect of PAG was significantly reversed by the H₂S donor sodium hydrosulfide (NaSH) in human (PAG + NaSH: 38.8 ± 7.2) and mouse (PAG + NaSH: 41.7 ± 3.1) arterioles, respectively. The endothelial NO synthase (eNOS) inhibitor, Nω-Nitro-l-arginine methyl ester (L-NAME), and the inhibitor of soluble guanylate cyclase (sGC), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) reversed the effect of PAG on the K⁺-induced vasoconstriction in the mouse arterioles and attenuated the K⁺-induced secondary dilatation significantly.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CSE contributes to the K⁺-induced vasoconstriction via a mechanism involving H₂S, eNOS, and sGC whereas the secondary dilatation is regulated by eNOS and sGC but not by CSE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":107,"journal":{"name":"Acta Physiologica","volume":"239 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apha.14021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6150198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-related differences in motor unit behavior are influenced by myosin heavy chain during high- but not moderate-intensity contractions","authors":"Alex A. Olmos,&nbsp;Adam J. Sterczala,&nbsp;Mandy E. Parra,&nbsp;Hannah L. Dimmick,&nbsp;Jonathan D. Miller,&nbsp;Jake A. Deckert,&nbsp;Stephanie A. Sontag,&nbsp;Philip M. Gallagher,&nbsp;Andrew C. Fry,&nbsp;Trent J. Herda,&nbsp;Michael A. Trevino","doi":"10.1111/apha.14024","DOIUrl":"https://doi.org/10.1111/apha.14024","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Motor unit recruitment and firing rate patterns of the vastus lateralis (VL) have not been compared between sexes during moderate- and high-intensity contraction intensities. Additionally, the influence of fiber composition on potential sex-related differences remains unquantified.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eleven males and 11 females performed 40% and 70% maximal voluntary contractions (MVCs). Surface electromyographic (EMG) signals recorded from the VL were decomposed. Recruitment thresholds (RTs), MU action potential amplitudes (MUAP_AMP), initial firing rates (IFRs), mean firing rates (MFRs), and normalized EMG amplitude (N-EMG_RMS) at steady torque were analyzed. <i>Y</i>-intercepts and slopes were calculated for MUAP_AMP, IFR, and MFR versus RT relationships. Type I myosin heavy chain isoform (MHC) was determined with muscle biopsies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were no sex-related differences in MU characteristics at 40% MVC. At 70% MVC, males exhibited greater slopes (<i>p</i> = 0.002) for the MUAP_AMP, whereas females displayed greater slopes (<i>p</i> = 0.001–0.007) for the IFR and MFR versus RT relationships. N-EMG_RMS at 70% MVC was greater for females (<i>p</i> &lt; 0.001). Type I %MHC was greater for females (<i>p</i> = 0.006), and was correlated (<i>p</i> = 0.018–0.031) with the slopes for the MUAP_AMP, IFR, and MFR versus RT relationships at 70% MVC (<i>r</i> = −0.599–0.585).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Both sexes exhibited an inverse relationship between MU firing rates and recruitment thresholds. However, the sex-related differences in MU recruitment and firing rate patterns and N-EMG_RMS at 70% MVC were likely due to greater type I% MHC and smaller twitch forces of the higher threshold MUs for the females. Evidence is provided that muscle fiber composition may explain divergent MU behavior between sexes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":107,"journal":{"name":"Acta Physiologica","volume":"239 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6127169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated in-depth fiber and nuclei typing in cross-sectional muscle images can pave the way to a better understanding of skeletal muscle diseases","authors":"Simone Baltrusch","doi":"10.1111/apha.14031","DOIUrl":"https://doi.org/10.1111/apha.14031","url":null,"abstract":"&lt;p&gt;In this issue of &lt;i&gt;Acta Physiologica&lt;/i&gt;, Lundquist et al.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; present a new platform for automated image data analysis of skeletal muscle samples. Immunohistochemical analysis can be used to visualize the fiber type composition of different skeletal muscles and their sex-specific adaptations with age, which are individually influenced by genetic predisposition, physical exercise, nutrition, stress, and environmental factors (Figure 1). Because of the correlation of muscle structure and physiology, the assessment can also provide an important contribution to the evaluation of diseased tissue. Over the past 5 years various image data analysis software have been developed that allow automated evaluation of immunohistochemical skeletal muscle cross-sectional images. Manual assessment limits the quantitative result in terms of representativeness, since only a small number of samples can be investigated due to the time required, and in terms of objectivity, which is highly dependent on the qualifications of the evaluator. In the future, automation of image data analysis will be crucial to compare results of skeletal muscle samples of animal models as well as on human biopsies from different research institutions and clinical centers. If the quality of sample preparation and microscopy is ensured, it would be possible to build global databases that could be used, for example, to improve the evaluation and therapy of rare muscle diseases—a worthwhile goal.&lt;/p&gt;&lt;p&gt;Some of the available evaluation routines for skeletal muscle cross-sectional images were programmed directly in MatLab (e.g., MyoView&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt;) or performed with paid software (e.g., Imaris&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt;). However, two open source image processing packages are mainly used in the community to analyze image data. One of these is Fiji/ImageJ, which was developed based on JAVA by an employee of the NIH and is constantly being expanded by a large team. Of the hundreds of plug-ins now written by the user community, Myosight,&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; MuscleJ,&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; Myosoft,&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; MyoVision,&lt;span&gt;&lt;sup&gt;7&lt;/sup&gt;&lt;/span&gt; QauntiMus&lt;span&gt;&lt;sup&gt;8&lt;/sup&gt;&lt;/span&gt; and one more macro&lt;span&gt;&lt;sup&gt;9&lt;/sup&gt;&lt;/span&gt; are available for the analysis of cross-sectional muscle samples. CellProfiler was created at the Broad Institute of MIT and Harvard and is permanently being improved there by a project team in the Cimini Lab. The software, written in Python, is thus also a free, open-source project into which anyone can write their own image processing algorithms as a new module. So far, Muscle2view&lt;span&gt;&lt;sup&gt;10&lt;/sup&gt;&lt;/span&gt; has been developed to evaluate cross-sectional samples of muscle based on CellProfiler. Lundquist et al. now introduce FiNuTyper (Fiber and Nucleus Typer) as a new module&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; (Figure 2). The question arises, which novel possibilities FiNuTyper opens for the evaluation of muscle cross-section samples","PeriodicalId":107,"journal":{"name":"Acta Physiologica","volume":"239 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apha.14031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6127168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal arterial infusion of tempol prevents medullary hypoperfusion, hypoxia, and acute kidney injury in ovine Gram-negative sepsis","authors":"Ashenafi H. Betrie,&nbsp;Shuai Ma,&nbsp;Connie P. C. Ow,&nbsp;Rachel M. Peiris,&nbsp;Roger G. Evans,&nbsp;Scott Ayton,&nbsp;Darius J. R. Lane,&nbsp;Adam Southon,&nbsp;Simon R. Bailey,&nbsp;Rinaldo Bellomo,&nbsp;Clive N. May,&nbsp;Yugeesh R. Lankadeva","doi":"10.1111/apha.14025","DOIUrl":"https://doi.org/10.1111/apha.14025","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Renal medullary hypoperfusion and hypoxia precede acute kidney injury (AKI) in ovine sepsis. Oxidative/nitrosative stress, inflammation, and impaired nitric oxide generation may contribute to such pathophysiology. We tested whether the antioxidant and anti-inflammatory drug, tempol, may modify these responses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following unilateral nephrectomy, we inserted renal arterial catheters and laser-Doppler/oxygen-sensing probes in the renal cortex and medulla. Noanesthetized sheep were administered intravenous (IV) <i>Escherichia coli</i> and, at sepsis onset, IV tempol (IVT; 30 mg kg⁻¹ h⁻¹), renal arterial tempol (RAT; 3 mg kg⁻¹ h⁻¹), or vehicle.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Septic sheep receiving vehicle developed renal medullary hypoperfusion (76 ± 16% decrease in perfusion), hypoxia (70 ± 13% decrease in oxygenation), and AKI (87 ± 8% decrease in creatinine clearance) with similar changes during IVT. However, RAT preserved medullary perfusion (1072 ± 307 to 1005 ± 271 units), oxygenation (46 ± 8 to 43 ± 6 mmHg), and creatinine clearance (61 ± 10 to 66 ± 20 mL min⁻¹). Plasma, renal medullary, and cortical tissue malonaldehyde and medullary 3-nitrotyrosine decreased significantly with sepsis but were unaffected by IVT or RAT. Consistent with decreased oxidative/nitrosative stress markers, cortical and medullary nuclear factor-erythroid-related factor-2 increased significantly and were unaffected by IVT or RAT. However, RAT prevented sepsis-induced overexpression of cortical tissue tumor necrosis factor alpha (TNF-α; 51 ± 16% decrease; <i>p</i> = 0.003) and medullary Thr-495 phosphorylation of endothelial nitric oxide synthase (eNOS; 63 ± 18% decrease; <i>p</i> = 0.015).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In ovine Gram-negative sepsis, renal arterial infusion of tempol prevented renal medullary hypoperfusion and hypoxia and AKI and decreased TNF-α expression and uncoupling of eNOS. However, it did not affect markers of oxidative/nitrosative stress, which were significantly decreased by Gram-negative sepsis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":107,"journal":{"name":"Acta Physiologica","volume":"239 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apha.14025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6163886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How the availability of information affects the responsibility of the researcher?","authors":"Anja B. Persson,&nbsp;Pontus B. Persson,&nbsp;Philipp Hillmeister","doi":"10.1111/apha.14022","DOIUrl":"https://doi.org/10.1111/apha.14022","url":null,"abstract":"&lt;p&gt;As a forum for the publication of high-quality original research in Physiology and related disciplines, &lt;i&gt;Acta Physiologica&lt;/i&gt; is, by its very nature, dedicated to the responsible advancement of scientific progress—and its communication. However, search terms such as “&lt;i&gt;responsible research&lt;/i&gt;” entered into the journal homepage search field will retrieve 0 results. For a quick coffee break, let us sit back and consider for a moment concepts of scientific progress, its drivers, pitfalls and mechanisms of motivation and control.&lt;/p&gt;&lt;p&gt;How are we, as authors, publishers and readers, implementing concepts of high-quality, responsible research and the dissemination of its results into our everyday actions?&lt;/p&gt;&lt;p&gt;Epistemology distinguishes science “from other domains of human culture by its progressive nature”.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Research theorists are working on the main questions defining &lt;i&gt;scientific progress&lt;/i&gt;, or rather, &lt;i&gt;scientific change&lt;/i&gt;; watching, dissecting and analyzing how it happens, in a strikingly similar manner to how other disciplines, such as the life sciences, investigate their subject matters. Does knowledge grow, for example, in spurts and stalls, or is it a continuous, cumulative process?&lt;/p&gt;&lt;p&gt;Nisbet&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; famously argued that the latter view characterizes the Modern Age: Knowledge is driven by a gradual accumulation of data, facts or information, to which consecutive generations of researchers contribute. The famous philosophers of Enlightenment trusted the process to move mankind ever further toward discovering, ultimately, the &lt;i&gt;truth&lt;/i&gt;. Thomas Kuhn, in the 1960s, coined the term “paradigm shifts,” when he contradicted this view: periodic revolutions, in his opinion, characterized scientific progress, while truth is not objective, but a consensus, based on what is known at a given point in time.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Stop here for a second and imagine how simple yet important it is to communicate this: While knowledge gained in a responsible, reproducible process underlies all evidence-based decision-making, there is never “the truth” to be found, only consensus, which changes, and even more rapidly so whenever a lot of resources and efforts are invested, as was the case during the 2020/21 pandemic.&lt;/p&gt;&lt;p&gt;At &lt;i&gt;Acta Physiologica&lt;/i&gt;, a lot of effort is invested into this responsible, reproducible process. Firstly, at &lt;i&gt;Acta Physiologica&lt;/i&gt;, we are highly invested in upholding top standards biomedical research reporting, updating biannual guidelines for both authors as well as editors and reviewers.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Not only are Guidelines for Authors and Reviewers regularly updated and reviewed rigorously, to publish high-quality original research and reviews: The journal encourages contributions from authors aiming at critically appraising and refining methods of scientific observation,&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; examination,&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; interpretation&lt;span&gt;&lt;s","PeriodicalId":107,"journal":{"name":"Acta Physiologica","volume":"239 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apha.14022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5661501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}