IF 3.4 4区医学

ChemMedChem Pub Date : 2026-04-28 DOI: 10.1002/cmdc.70283

Ziyi Wang, Yongquan Wei, Zexu Xing, Lihe Jiang, Lisheng Wang

{"title":"Design, Synthesis, and Biological Evaluation of Indolin-2-One-Matrine Derivatives as Potential VEGFR-2-Targeting Agents for Hepatocellular Carcinoma.","authors":"Ziyi Wang, Yongquan Wei, Zexu Xing, Lihe Jiang, Lisheng Wang","doi":"10.1002/cmdc.70283","DOIUrl":"https://doi.org/10.1002/cmdc.70283","url":null,"abstract":"Inhibition of the VEGF/VEGFR-2 pathway is a validated strategy to suppress tumor angiogenesis and progression; however, long-term use of several VEGFR-2 tyrosine kinase inhibitors is limited by resistance and systemic toxicity. Here, a series of novel indolinone-matrine hybrids were designed and synthesized via a molecular hybridization strategy. The antiproliferative activities were evaluated against human hepatocellular carcinoma (HCC) cell lines (HepG-2, HuH7, and MHCC97H). Among them, J9 showed the most potent activity with IC50 values of 5.81, 2.14, and 3.03 μM, respectively, and relatively low cytotoxicity toward HEK-293 cells (IC50 = 27.90 μM) and HL7702 cells (IC50 = 52.23 μM). In HuH7 cells, J9 significantly inhibited colony formation and migration, induced G1-phase arrest, and promoted apoptosis in a dose-dependent manner. Western blot analysis indicated that J9 treatment was associated with downregulation of VEGFR-2 and activation of caspase-dependent apoptosis (increased cleaved caspase-3 and cleaved PARP). Moreover, J9 inhibited VEGFR-2 kinase in vitro (IC50 = 253.51 ± 1.21 nM), and docking/MD simulations suggested stable binding within the VEGFR-2 ATP-binding pocket. Collectively, J9 represents a promising matrine-derived antitumor candidate with potential VEGFR-2-targeting activity.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 8","pages":"e70283"},"PeriodicalIF":3.4,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Active and Passive Targeting Drug Delivery Systems as a Mechanism to Improve the Anticancer Potential of Titanium(IV). 评价主动和被动靶向药物传递系统作为提高钛抗癌潜力的机制（IV）。

IF 3.4 4区医学

ChemMedChem Pub Date : 2026-04-28 DOI: 10.1002/cmdc.70284

Oscar Claudio-Ares, Mallesh Pandrala, Lauren Fernández-Vega, Barbara Casañas-Montes, Josué Benjamín-Rivera, Louis R Parham, Carlo Marra Nazario, José F Cátala Torres, Gretchen Castro Lebron, Jorge L Colón, Arthur D Tinoco

{"title":"Evaluation of Active and Passive Targeting Drug Delivery Systems as a Mechanism to Improve the Anticancer Potential of Titanium(IV).","authors":"Oscar Claudio-Ares, Mallesh Pandrala, Lauren Fernández-Vega, Barbara Casañas-Montes, Josué Benjamín-Rivera, Louis R Parham, Carlo Marra Nazario, José F Cátala Torres, Gretchen Castro Lebron, Jorge L Colón, Arthur D Tinoco","doi":"10.1002/cmdc.70284","DOIUrl":"https://doi.org/10.1002/cmdc.70284","url":null,"abstract":"Titanium(IV) compounds are promising anticancer agents, but their development is hindered by poor aqueous stability and/or inefficient cellular delivery. This study compares two Ti(IV) compounds with contrasting properties: titanocene-dichloride (TDC), which rapidly hydrolyzes at physiological pH, and the more stable chelated complex [Ti(deferasirox)2] (Ti(Def)2), which has limited cellular uptake. To overcome these limitations, passive and active cell targeting drug delivery systems were explored. TDC was intercalated into layered zirconium phosphate nanoparticles (TDC@ZrP), passive carriers enabling acid-triggered release under lysosomal environments. Bovine serum albumin (BSA) binding and conjugation to receptor-targeted deferasirox-peptide ligands were used as active carriers. TDC@ZrP increased intracellular Ti(IV) uptake by ∼ 26-fold relative to free TDC, yet without an increase in antiproliferative activity. Similarly, stabilization with BSA enhanced solution stability but not cytotoxicity. In contrast, Ti(Def)2 showed transporter-dependent activity. While albumin binding reduced its efficacy, conjugation to a transferrin receptor-1 targeting peptide significantly enhanced titanium uptake and cytotoxicity. Targeting the neurokinin-1 receptor had minimal effect, consistent with low receptor expression. Overall, these findings demonstrate that ligand identity is critical, as deferasirox not only controls Ti(IV) release but also contributes to cytotoxicity, highlighting the importance of metal-ligand design in improving anticancer performance.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 8","pages":"e70284"},"PeriodicalIF":3.4,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Triose Phosphate Isomerase Inhibitor With Dual Trypanosomicidal Activity was Identified Using Artificial Intelligence-Based Virtual Screening. 采用基于人工智能的虚拟筛选技术，鉴定出一种具有双重杀锥虫活性的新型磷酸三糖异构酶抑制剂。

IF 3.4 4区医学

ChemMedChem Pub Date : 2026-04-28 DOI: 10.1002/cmdc.202500896

Elena Aguilera, Rachel Ramos, Aram Davtyan, Nallely Cabrera, Ruy Perez-Montfort, Elva Serna, Gloria Yaluff, Guzmán Alvarez

{"title":"A Novel Triose Phosphate Isomerase Inhibitor With Dual Trypanosomicidal Activity was Identified Using Artificial Intelligence-Based Virtual Screening.","authors":"Elena Aguilera, Rachel Ramos, Aram Davtyan, Nallely Cabrera, Ruy Perez-Montfort, Elva Serna, Gloria Yaluff, Guzmán Alvarez","doi":"10.1002/cmdc.202500896","DOIUrl":"10.1002/cmdc.202500896","url":null,"abstract":"Chagas disease and leishmaniasis are neglected protozoan diseases recognized by the World Health Organization as major public health problems. These diseases affect millions of people worldwide, yet effective treatments remain unavailable. Triosephosphate isomerase (TIM), a glycolytic enzyme that exhibits high catalytic efficiency for the isomerization of glyceraldehyde-3-phosphate and dihydroxyacetone-phosphate exclusively in its dimeric form, was subjected to virtual screening. Using a deep neural network for structure-based drug design that predicts binding affinity between small molecules and proteins of known structure, 12.5 million commercially available compounds were screened. From this, 82 compounds were selected for in vitro evaluation. Six compounds inhibited TIM from Trypanosoma cruzi, three of which exhibited anti-T. cruzi activity. Eight compounds demonstrated activity against the parasites T. cruzi and Leishmania infantum. Two compounds showed similar potency against both parasites: 3-(1-acetyl-5-(4-bromophenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4-hydroxy-6-methyl-2H-pyran-2-one (IC50 = 16 ± 3 μM) and 3-[(4-bromophenyl)sulfanyl]-1-(3-nitrophenyl)propan-1-one (IC50 = 12 ± 1 μM). These compounds exhibit favorable selectivity and toxicological profiles, as well as in vivo activity, indicating their potential for future drug development.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 8","pages":"e202500896"},"PeriodicalIF":3.4,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allium-Derived Compounds Against Multidrug-Resistant Bacteria: Antibacterial Activity and Synergistic Effects. 大蒜衍生化合物对多重耐药细菌的抑菌活性及协同作用。

IF 3.4 4区医学

ChemMedChem Pub Date : 2026-04-28 DOI: 10.1002/cmdc.202501034

Antonio Sorlózano-Puerto, Yariel Figueroa-Vega, Pablo Martín-Valenzuela, José Manuel de la Torre-Ramírez, Alberto Baños, José Gutiérrez-Fernández

{"title":"Allium-Derived Compounds Against Multidrug-Resistant Bacteria: Antibacterial Activity and Synergistic Effects.","authors":"Antonio Sorlózano-Puerto, Yariel Figueroa-Vega, Pablo Martín-Valenzuela, José Manuel de la Torre-Ramírez, Alberto Baños, José Gutiérrez-Fernández","doi":"10.1002/cmdc.202501034","DOIUrl":"https://doi.org/10.1002/cmdc.202501034","url":null,"abstract":"Background and objectives: Antibiotic resistance is a major global health challenge, driven by misuse in medicine and agriculture and the scarcity of new drugs. Allium-derived organosulfur molecules have shown antimicrobial and synergistic effects with antibiotics. This study aimed to evaluate the in vitro antibacterial activity of four Allium-derived compounds and their potential synergy with clinical antibiotics against multidrug-resistant bacteria.Methods: A total of 330 multidrug-resistant clinical isolates were analyzed, including Gram-positive cocci and Gram-negative bacilli. Antibacterial activity of propyl-propane-thiosulfinate, propyl-propane-thiosulfonate (PTSO), butyl-butane-thiosulfinate, and butyl-butane-thiosulfonate was determined by broth microdilution. Synergy with conventional antibiotics was assessed in 24 representative isolates using the checkerboard method, with interactions classified by the fractional inhibitory concentration index.Results: PTSO exhibited the highest activity, with MIC50 of 4-8 µg/mL and MIC90 up to 8 µg/mL against S. aureus, E. faecalis, and S. agalactiae. Activity against Gram-negative bacteria was limited, though PTSO was the most active. Checkerboard assays showed predominantly indifferent interactions, but partial synergy with aminoglycosides was observed in both Gram-positive and Gram-negative bacteria.Conclusion: PTSO demonstrated the most significant activity against multidrug-resistant Gram-positive bacteria, with limited impact on Gram-negative strains, and partial synergy with aminoglycosides suggests a potential role for combination therapy.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 8","pages":"e202501034"},"PeriodicalIF":3.4,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13116028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fair and Square: Design, Synthesis and Biological Evaluations of Squaric Acid Derivatives as Novel HDAC8 Inhibitors. 公平公正：方酸衍生物作为新型HDAC8抑制剂的设计、合成和生物学评价。

IF 3.4 4区医学

ChemMedChem Pub Date : 2026-04-28 DOI: 10.1002/cmdc.70270

Nathan Long, Franz-Josef Meyer-Almes, Aleksandra Kopranovic, Stephen P Wren

{"title":"Fair and Square: Design, Synthesis and Biological Evaluations of Squaric Acid Derivatives as Novel HDAC8 Inhibitors.","authors":"Nathan Long, Franz-Josef Meyer-Almes, Aleksandra Kopranovic, Stephen P Wren","doi":"10.1002/cmdc.70270","DOIUrl":"https://doi.org/10.1002/cmdc.70270","url":null,"abstract":"Histone deacetylase 8 (HDAC8) is a clinically validated target in neuroblastoma, where isoform selective inhibition offers a strategy to suppress tumour growth while limiting off-target toxicity. Hydroxamic acids remain the dominant zinc-binding group (ZBG) in HDAC inhibitors but are also associated with metabolic instability, suboptimal pharmacokinetics and nonspecific metal chelation. In this study, we report the biological evaluation of a focussed library of 51 squaric acid derivatives as alternative, non-hydroxamic HDAC inhibitors. While a subset of these compounds has been described previously in a synthetic context, their HDAC inhibitory activity and selectivity have not been reported to date. The compounds organised into four structural subfamilies were screened against HDAC8 with moderate isoform selectivity. Structure activity relationships, supported by molecular docking and in silico techniques, highlight the influence of substitution pattern, electronic properties and molecular rigidity on HDAC8 inhibition. Collectively, these findings establish squaric acid derivatives as a viable non-hydroxamic acid scaffold for the development of selective HDAC inhibitors.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 8","pages":"e70270"},"PeriodicalIF":3.4,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Series of Amino Alcohol Oxime Ethers as Activators of Human Brain Carbonic Anhydrases: Advances in Selective Activation of Human Carbonic Anhydrase VII. 一类新的氨基醇肟醚作为人脑碳酸酐酶的激活剂——选择性激活人碳酸酐酶的研究进展。

IF 3.4 4区医学

ChemMedChem Pub Date : 2026-04-28 DOI: 10.1002/cmdc.70272

Camilla Mangini, Riccardo Di Leo, Jacopo Castagnoli, Alessio Nocentini, Paola Gratteri, Sabrina Taliani, Claudiu T Supuran, Armando Rossello, Doretta Cuffaro, Elisa Nuti

{"title":"A New Series of Amino Alcohol Oxime Ethers as Activators of Human Brain Carbonic Anhydrases: Advances in Selective Activation of Human Carbonic Anhydrase VII.","authors":"Camilla Mangini, Riccardo Di Leo, Jacopo Castagnoli, Alessio Nocentini, Paola Gratteri, Sabrina Taliani, Claudiu T Supuran, Armando Rossello, Doretta Cuffaro, Elisa Nuti","doi":"10.1002/cmdc.70272","DOIUrl":"https://doi.org/10.1002/cmdc.70272","url":null,"abstract":"Carbonic anhydrases (CAs) are ubiquitous metalloenzymes that catalyze the interconversion of carbon dioxide and water to bicarbonate and proton. Given CA crucial role in carbon-based life, CA inhibition is a well-known therapeutic strategy for several diseases. However, in recent years, CA activation has emerged as a promising therapeutic approach for neurodegenerative conditions such as Alzheimer's disease, generalized anxiety, phobias and post-traumatic stress disorder. In this study, a new series of amino alcohol oxime ethers was synthesized from hit compound A to enhance its activity and selectivity towards four brain hCA isoforms, particularly hCA VII, which plays a key role in regulating neuronal pH related to synaptic plasticity and cognitive performance. Herein, we report a structure-activity relationship analysis to identify compounds that are both potent and selective activators for hCA VII. Among the synthesized derivatives, the morpholino propyl compound 12 emerged as the most active (KA = 72 nM) and selective over other brain isoforms. These results were further supported by in silico studies, which revealed favorable binding interactions at site A due to structural features present in both R and S enantiomers of compound 12.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 8","pages":"e70272"},"PeriodicalIF":3.4,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper(II)-Tripeptide Complexes as Potential Skin Healing Agents: Synthesis, Characterization, and Wound Repair Ability. 铜(II)-三肽复合物作为潜在的皮肤愈合剂：合成、表征和伤口修复能力。

IF 3.4 4区医学

ChemMedChem Pub Date : 2026-04-28 DOI: 10.1002/cmdc.202501023

Lorena Aguilar, Emiliano Garcia Gabastú, Mateo Schaffner, Cristian Justet, L Felipe Santos Mendes, Marcos V Palmeira-Mello, Alzir A Batista, Gianella Facchin, Natalia Alvarez, María H Torre

{"title":"Copper(II)-Tripeptide Complexes as Potential Skin Healing Agents: Synthesis, Characterization, and Wound Repair Ability.","authors":"Lorena Aguilar, Emiliano Garcia Gabastú, Mateo Schaffner, Cristian Justet, L Felipe Santos Mendes, Marcos V Palmeira-Mello, Alzir A Batista, Gianella Facchin, Natalia Alvarez, María H Torre","doi":"10.1002/cmdc.202501023","DOIUrl":"https://doi.org/10.1002/cmdc.202501023","url":null,"abstract":"Due to the rising incidence of skin diseases, the World Health Organization has emphasized the need for improved prevention and treatment strategies. The search for new compounds active against skin lesions and pathologies has attracted significant attention. This work reports the synthesis, analytical, spectroscopic, and electrochemical characterization of four copper(II)-tripeptide complexes using Gly-Gly-Ile (GGI), Ala-Ala-Ala (AAA), Phe-Gly-Gly (FGG), and Val-Tyr-Val (VYV) as ligands. Results show that GGI, AAA, and FGG monodeprotonate and coordinate to copper(II) through the aminic N and the adjacent carbonyl O, following a 1:2 metal-to-ligand stoichiometry. VYV doubly deprotonates and forms a 1:1 complex with the tripeptide coordinated through the aminic N atom a deprotonated amidic N and a carbonyl O. Aqueous solution studies confirm that the tripeptide stays coordinated in the major species in solution. Complexes are redox active in the biologically relevant window, with CuVYV presenting the most accessible Cu(III)/Cu(II) transition. The ability to promote wound healing was assessed through a scratch wound healing assay. CuAAA and CuVYV are promising inducers of wound healing by promoting migration in MRC-5 cells. Cytotoxicity assays confirm that the compounds are not cytotoxic at the doses used for wound repair, making CuAAA and CuVYV interesting candidates for further studies.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 8","pages":"e202501023"},"PeriodicalIF":3.4,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, and Evaluation of New Polyhydroxylated Bis-Chalcones as Potential COX-2 Selective Inhibitors. 新型多羟基双查尔酮作为COX-2选择性抑制剂的设计、合成和评价。

IF 3.4 4区医学

ChemMedChem Pub Date : 2026-04-28 DOI: 10.1002/cmdc.202500784

Rui Pereira, Alberto N Araújo, Daniela Ribeiro, Ismael Rufino, Nuno Martinho, Rita C Guedes, Vera L M Silva, Eduarda Fernandes

{"title":"Design, Synthesis, and Evaluation of New Polyhydroxylated Bis-Chalcones as Potential COX-2 Selective Inhibitors.","authors":"Rui Pereira, Alberto N Araújo, Daniela Ribeiro, Ismael Rufino, Nuno Martinho, Rita C Guedes, Vera L M Silva, Eduarda Fernandes","doi":"10.1002/cmdc.202500784","DOIUrl":"https://doi.org/10.1002/cmdc.202500784","url":null,"abstract":"Selective inhibition of COX-2 is considered one of the best strategies for treating chronic inflammatory diseases. However, the currently available options still have significant side effects due to exacerbated selectivity. Bis-chalcone derivatives have shown promising anti-inflammatory properties with reduced side effects. In this study, a family of polyhydroxylated bis-chalcones was synthesized and tested in vitro for their ability to inhibit human COX-2 and COX-1 and to assess selectivity. To further understand their mechanism of action, inhibitory kinetic analysis and in silico molecular docking calculations were performed. The results showed that bis-chalcone 31, with hydroxy groups at positions 3' and 4' of the B rings and three hydroxy groups at the center, was the most active. It was recognized as a mixed-type inhibitor with balanced selectivity. With molecular docking, it was observed that this substitution pattern provided bis-chalcone 31 with additional bulk that hindered its access to the active pocket of COX-1 over COX-2. Also, compound 31 establishes additional hydrogen bonds within the COX-2 pocket that bis-chalcone 30 did not, therefore explaining the selectivity and superior potency of bis-chalcone 31. In conclusion, bis-chalcone 31 with multiple hydroxy groups in its structure shows promising properties for the design of new COX-2 selective inhibitors.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 8","pages":"e202500784"},"PeriodicalIF":3.4,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of 2-Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti-Angiogenesis Properties. 具有抗血管生成特性的2-芳基（烷基）苯并咪唑羟肟酸的合成。

IF 3.4 4区医学

ChemMedChem Pub Date : 2026-04-28 DOI: 10.1002/cmdc.202500984

Yi-Ting Liu, Cheng-Ta Lai, Shih-Wei Wang, Shan-Chi Liu, Yi-Lin Hwang, Yi-Chen Tsai, Chi-Yeh Lee, Yu-Wei Lai, Juei-Yu Yen, Po-Chuan Wang, Hsueh-Yun Lee

引用次数: 0

In Vitro Evaluation of PARP1 Inhibitor Olaparib-Cyanine Dye Conjugate for the Treatment of Glioblastoma. PARP1抑制剂奥拉帕尼-菁染料偶联物治疗胶质母细胞瘤的体外评价。

IF 3.4 4区医学

ChemMedChem Pub Date : 2026-04-28 DOI: 10.1002/cmdc.70286

Carina Dumo, Faheem, Peter J Choi, Nicholas J Pederson, Yuge Liu, Mike Dragunow, Thomas I-H Park, Katharine L Diehl, Jiney Jose

引用次数: 0

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