从工作台到浏览器：Reddit化学家如何在药物化学中塑造人工智能、流动化学、aso和可持续性

IF 4 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-09-01 DOI:10.1021/acsmedchemlett.5c00483

Harsh Mehta*,

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引用次数: 0

摘要

像Reddit这样的在线论坛，特别是像r/chemistry和r/medchem这样的子论坛，提供了对学术界和工业界药物化学家的实际优化，挫折和起源的未经过滤的看法。本文基于对2022年至2024年间Reddit的系统性话语回顾，捕捉了从业者对四个关键趋势（AI/ML工具、流动化学、反义寡核苷酸（ASOs）和可持续性）的看法和解释。通过这些坦率的讨论，确定的创新遇到了瓶颈，突出了对人工智能黑箱性质的担忧，对连续流合成的热情，对rna靶向治疗的争论，以及对循环化学的越来越多的倡导。这些基层信号为药物化学界提供了值得赞赏的早期指标，敦促在研究重点确定和政策制定中更好地整合从业者的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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From Bench to Browser: How Reddit Chemists Are Shaping AI, Flow Chemistry, ASOs, and Sustainability in Medicinal Chemistry

Online forums like Reddit, particularly subreddits such as r/chemistry and r/medchem, offer an unfiltered look at the practical optimizms, frustrations, and originations of medicinal chemists across academia and industry. This Viewpoint captures practitioner sentiment and explanation on four pivotal trends─AI/ML tools, flow chemistry, antisense oligonucleotides (ASOs), and sustainability─based on methodical Reddit discourse review between 2022 and 2024. Through these candid deliberations, the identified innovation meets bottleneck, highlighting fears over AI’s black-box nature, enthusiasm over continuous flow synthesis, debates on RNA-targeted therapies, and growing advocacy for circular chemistry. These grassroots signals offer appreciated early indicators for the medicinal chemistry community, urging superior integration of practitioner insight in research priority setting and policy preparation.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.