含叔胺双环化合物作为T细胞活化剂的研究进展

IF 4 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-08-28 DOI:10.1021/acsmedchemlett.5c00496

Taoqian Zhao, and , Steven H. Liang*,

引用次数: 0

摘要

本发明涉及一系列由叔胺取代的双环化合物，其激活T细胞，促进其增殖，和/或表现出抗肿瘤作用，如式1所示。这些化合物在治疗诸如癌症和病毒感染等增殖性疾病方面显示出巨大的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Development of Bicyclic Compounds Containing a Tertiary Amine Moiety as T Cell Activators

This invention relates to a series of bicyclic compounds substituted with a tertiary amine, represented by formula I, that activate T cells, promote their proliferation, and/or exhibit antitumor effects. These compounds show significant promise as therapeutic agents for managing proliferative conditions, such as cancer, and viral infections.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.