Zi-Jian Qu, Wen-Juan Shi, Zhao-Lu Wang, Cong-Fu Zhang, Hong-Jun Liu
{"title":"Strong electric field enhancement near an amorphous silicon metasurface with non-vertical symmetry.","authors":"Zi-Jian Qu, Wen-Juan Shi, Zhao-Lu Wang, Cong-Fu Zhang, Hong-Jun Liu","doi":"10.1039/d5nh00225g","DOIUrl":"https://doi.org/10.1039/d5nh00225g","url":null,"abstract":"<p><p>In this work, we propose a novel method to our knowledge for realizing a leakage mode with a super flat band through the modulation of two Friedrich-Wintgen bound states in the continuum (FW BICs) of a non-vertical symmetry metasurface. This unique mode is formed by partially breaking the BIC generated from the first excited collective magnetic dipole (MD) resonance in a sub-diffraction periodic system, which exhibits a low group velocity of 16 731 m s<sup>-1</sup>, while its quality factor (<i>Q</i> factor) is 217. We calculate that the near electric field enhancement reached 808 times at an incident angle <i>θ</i> of 9°22'. Our findings provide unique opportunities for realizing strong-enhanced nonlinear effects in metasurfaces.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yanzhong Wang, Yuhang Zhang, Miao Yu, Peng Xiu, Yanwei Jia, Hu Chen, Shimin Le, Jin Qian, Jie Yan
{"title":"Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats.","authors":"Yanzhong Wang, Yuhang Zhang, Miao Yu, Peng Xiu, Yanwei Jia, Hu Chen, Shimin Le, Jin Qian, Jie Yan","doi":"10.1039/d5nh00112a","DOIUrl":"https://doi.org/10.1039/d5nh00112a","url":null,"abstract":"<p><p>Spectrin superfamily proteins play essential roles in cells by interlinking various cytoskeletal components and bridging the cytoskeleton to both the cell membrane and the nucleus. Characterized by the spectrin repeat (SR) domain, this superfamily features a unique bundle of three antiparallel α-helices. These SRs often appear as tandem repeats linked by short segments, serving as tension-bearing structural units that support the cytoskeleton and act as signaling hubs for numerous proteins. Although the cooperative force-dependent unfolding of tandem spectrin repeats is well-documented, the precise molecular mechanisms remain unclear. In this study, we used the paradigmatic tandem SR (SR3-SR4) of α-actinin as our model system. Our results reveal that cooperativity arises from the salt bridges on the linker between the two domains. Additionally, we found that the salt bridge mechanically stabilizes the two domains, extending the lifetime of SR3-SR4 by 10 to 100 times compared to individual domains. Our full-atom MD simulations show that the linker salt bridge is a major force-bearing point, and its disruption leads to the mechanical unfolding of the domains. Finally, combining AlphaFold structural prediction and single-molecule manipulation studies of other spectrin superfamily proteins, we demonstrate that linker salt bridge-mediated cooperativity and stabilization is a potentially conserved molecular mechanism governing the mechanical responses of SRs in spectrin superfamily proteins.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tattoo electrodes in bioelectronics: a pathway to next-generation wearable systems.","authors":"Jinwoo Lee, Seung Hwan Ko","doi":"10.1039/d5nh00175g","DOIUrl":"https://doi.org/10.1039/d5nh00175g","url":null,"abstract":"<p><p>Tattoo-based electronics have emerged as a transformative platform for next-generation wearable bioelectronics. Unlike conventional wearable devices, which rely on substrates, tattoo electrodes are directly formed or transferred onto the skin or internal organs, ensuring superior comfort, breathability, and long-term usability. This intimate interface minimizes motion-induced artifacts and enables reliable biosignal acquisition across diverse physiological and anatomical regions. However, the absence of a supporting substrate imposes unique challenges in fabrication and material design. The fabrication processes must be tailored to accommodate direct skin application, and the selection of functional materials is more constrained. Materials must not only be biocompatible and flexible but also capable of maintaining performance under the dynamic conditions of the human body. This review presents a comprehensive overview of tattoo electrode technology, beginning with fabrication strategies, including direct and indirect patterning methods. We then discuss a range of materials, such as metallic networks, carbon-based materials, polymers, and materials recently being studied. Finally, we explore the diverse applications of tattoo electrodes in strain and electrophysiological sensing, temperature and humidity detection, biochemical monitoring, and energy harvesting and storage. Through this review, we aim to highlight the potential and future directions of tattoo-based electronic systems.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Outstanding Reviewers for <i>Nanoscale Horizons</i> in 2024.","authors":"","doi":"10.1039/d5nh90028j","DOIUrl":"https://doi.org/10.1039/d5nh90028j","url":null,"abstract":"<p><p>We would like to take this opportunity to thank all of <i>Nanoscale Horizons</i>' reviewers for helping to preserve quality and integrity in the nanoscience literature. We would also like to highlight the Outstanding Reviewers for <i>Nanoscale Horizons</i> in 2024.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrey Ten, Christina Boukouvala, Vladimir Lomonosov, Emilie Ringe
{"title":"Colloidal synthesis and etching yield monodisperse plasmonic quasi-spherical Mg nanoparticles.","authors":"Andrey Ten, Christina Boukouvala, Vladimir Lomonosov, Emilie Ringe","doi":"10.1039/d5nh00205b","DOIUrl":"10.1039/d5nh00205b","url":null,"abstract":"<p><p>Mg is a low-cost, earth-abundant, and biocompatible plasmonic metal. Fine tuning of its optical response, required for successful light-harvesting applications, can be achieved by controlling Mg nanoparticle size and shape. Mg's hexagonal close packed crystal structure leads to the formation of a variety of unique shapes in colloidal synthesis, ranging from single crystalline hexagonal platelets to twinned rods. Yet, shape control in colloidal Mg nanoparticle synthesis is challenging due to complex nucleation and growth kinetics. Here, we present an approach to manipulate Mg nanoparticle shape by one-pot synthesis followed by colloidal etching with polycyclic aromatic hydrocarbons. We demonstrate how tips and edges in faceted Mg nanoparticles can be preferentially etched to produce quasi-spherical nanoparticles with smooth surfaces. The developed approach provides an essential shape control tool in colloidal Mg synthesis potentially applicable to other oxidising metals.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ren Wang, Guangzhao Mao, Dewei Chu, Noushin Nasiri, Yuling Wang, Marcela Bilek, Ken-Tye Yong, Wallace Wong, Stan Skafidas, Jefferson Zhe Liu, Yuri Kivshar, Madhu Bhaskaran, Yuerui Lu, Benjamin Eggleton, Arnold Ju, Qianqian Shi, Nam-Trung Nguyen, Chwee Teck Lim, Wenlong Cheng
{"title":"Wet chemically produced nanomaterials for soft wearable biosensors.","authors":"Ren Wang, Guangzhao Mao, Dewei Chu, Noushin Nasiri, Yuling Wang, Marcela Bilek, Ken-Tye Yong, Wallace Wong, Stan Skafidas, Jefferson Zhe Liu, Yuri Kivshar, Madhu Bhaskaran, Yuerui Lu, Benjamin Eggleton, Arnold Ju, Qianqian Shi, Nam-Trung Nguyen, Chwee Teck Lim, Wenlong Cheng","doi":"10.1039/d5nh00048c","DOIUrl":"https://doi.org/10.1039/d5nh00048c","url":null,"abstract":"<p><p>Wearable biosensors are gaining significant attention for their ability to monitor vital health signs remotely, continuously, and non-invasively. Nanomaterials offer transformative potential for next-generation soft wearable sensors, enabling seamless skin integration with enhanced comfort and data accuracy. Wet chemistry provides a scalable, cost-effective approach to producing nanomaterials, transforming rigid sensors into soft, flexible, and stretchable devices for broader wearable applications. This review highlights recent advances in soft wearable biosensors based on wet chemically produced nanomaterials, including metals, carbons, conducting polymers, conductive hydrogels, and liquid metals. It discusses fabrication techniques such as conductive ink formulation, ink delivery, electroless coating, and fiber integration, along with applications in physiological, physical, and biochemical monitoring. The review concludes by addressing challenges and opportunities, emphasizing the potential of these sensors in revolutionizing medical technology and personalized healthcare.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the intricacies of protein-nanoparticle interaction and its implications in chronic diseases: a comprehensive review.","authors":"Pallavi Samal, Siddharth Satpathy, Lipsa Leena Panigrahi, Suman Jha, Manoranjan Arakha","doi":"10.1039/d5nh00076a","DOIUrl":"https://doi.org/10.1039/d5nh00076a","url":null,"abstract":"<p><p>The protein and nanoparticle interaction is the basis of nanoparticle bio-reactivity. Nanoparticles upon interaction with proteins form a protein corona, altering their characteristics. This corona influences nanoparticles' biodistribution, pharmacokinetics, and therapeutic efficacy. The complex protein-nanoparticle interactions have a significant impact on the emergence of chronic inflammation and chronic diseases. This study is a comprehensive review that explores the dynamic nature of protein-nanoparticle interactions, emphasizing their long-term effects on sustained inflammatory responses and subsequent implications for various chronic conditions, and not an exhaustive review of all aspects. This study investigates the role of nanoparticle characteristics such as the size, shape, and surface charge in the formation of a protein corona, addressing the molecular aspects and cellular pathways involved. The connection between protein-nanoparticle interactions and chronic inflammation is deeply explored in the context of specific diseases, including cardiovascular disorders, neurological conditions, respiratory ailments, metabolic disorders, autoimmune conditions, and cancer. Insights from <i>in vivo</i> and clinical studies, coupled with discussions on genotoxicity, immunotoxicity, and mitigation strategies, contribute to a deeper understanding of the broader implications of these interactions. Nevertheless, this serves as a foundational framework for grasping the pivotal advancements and breakthroughs achieved <i>via</i> recent novel perspectives concerning the advanced methodologies for investigating protein-nanoparticle interaction and its correlation with chronic diseases. Additionally, this endeavour seeks to identify existing knowledge gaps demanding thorough exploration and offers insights for enhancing our knowledge of the interplay between protein-nanoparticle interactions and chronic disease pathogenesis. By addressing ethical considerations and public perceptions, this review outlines future research directions, highlighting the importance of extending our understanding of the safe and effective integration of nanotechnology into a broad range of applications.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed A Abdelfattah, Sina S Jamali, Navid Kashaninejad, Nam-Trung Nguyen
{"title":"Wearable biosensors for health monitoring: advances in graphene-based technologies.","authors":"Mohamed A Abdelfattah, Sina S Jamali, Navid Kashaninejad, Nam-Trung Nguyen","doi":"10.1039/d5nh00141b","DOIUrl":"https://doi.org/10.1039/d5nh00141b","url":null,"abstract":"<p><p>The human body is an intelligent system, continuously generating signals that correlate with specific vital activities and indicate the state of our health and fitness. Therefore, accurate and real-time tracking of these signals is important for monitoring our health and timely medical interventions. The quantification of these signals in real-time is made possible by using skin wearable devices that detect disease-related biomarkers in bodily fluids, such as sweat and interstitial fluid. Integrating nanomaterials, particularly graphene, into wearable devices has dramatically enhanced the performance of wearable biosensors. The exemplary electrical properties, mechanical flexibility, and biocompatibility of graphene have made it a revolutionary material to shape the future of wearable devices. Graphene is versatile because its surface chemistry can be easily tuned to accommodate different biorecognition elements. This review provides an overview of flexible wearable biosensing devices, their sampling methods, and how microfluidic approaches enhance their performance. The paper also discusses the different strategies for the synthesis of graphene nanostructures, their integration into wearable systems, and their ability to improve sensing performance. Various surface chemistry modification techniques are also explored for the enhancement of the immobilisation of biomolecules. Finally, the paper discusses the challenges of graphene-based wearable technologies and their roles in continuous health monitoring and personalised medicine.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yin Li, Kebing Chen, Liangliang Zhu, Qing Li, Su Chen
{"title":"Microfluidic fiber-spinning chemistry for hydrophilic-hydrophobic Janus membranes towards efficient interfacial solar evaporation.","authors":"Yin Li, Kebing Chen, Liangliang Zhu, Qing Li, Su Chen","doi":"10.1039/d5nh00186b","DOIUrl":"https://doi.org/10.1039/d5nh00186b","url":null,"abstract":"<p><p>Janus nanofiber membrane has emerged as a promising solar-driven interfacial evaporator for seawater desalination. However, salt ion accumulation and crystallization persist during long-term operation, which remains a key challenge. In this work, we report a hydrophilic-hydrophobic Janus nanofiber membrane evaporator, which is prepared <i>via</i> continuous microfluidic electrospinning. This method allows <i>in situ</i> chemical reaction of tannin (TA) and Fe<sup>3+</sup> to be carried out in a \"Y\" chip during the spinning process, enabling rapid, facile, and flexible fabrication of the nanofiber membrane. TA is rich in hydroxyl groups, which endows the bottom layer with hydrophilicity and electronegativity, thereby enhancing the water transport and Donnan effect. Thus, a high evaporation rate of 1.73 kg m<sup>-2</sup> h<sup>-1</sup> in pure water is achieved. More importantly, long-term stability in seawater desalination is realized with an evaporation rate of 1.68 kg m<sup>-2</sup> h<sup>-1</sup>, and there is no salt crystallization on the surface during continuous evaporation for 8 hours in 10 wt% NaCl solution. On the one hand, the bottom layer shows electronegativity, which is liable to immobilize cations Na<sup>+</sup> and repel anions Cl<sup>-</sup>, achieving the purpose of salt resistance. On the other hand, the Janus structure also favors the redissolution of concentrated salts into raw water, further avoiding salt accumulation. This work offers a promising common strategy for constructing high-performance Janus evaporator, which will stimulate the development of seawater desalination.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Verónica Mora-Sanz, Laura Saa, Valeri Pavlov, Aitziber L Cortajarena, Bergoi Ibarlucea, Nerea Briz
{"title":"Dot-blot immunoassay based on antibody-nanocluster biohybrids as tags for naked-eye detection.","authors":"Verónica Mora-Sanz, Laura Saa, Valeri Pavlov, Aitziber L Cortajarena, Bergoi Ibarlucea, Nerea Briz","doi":"10.1039/d5nh00045a","DOIUrl":"https://doi.org/10.1039/d5nh00045a","url":null,"abstract":"<p><p>Paper-based assays such as dot-blot show high promise to develop point-of-care testing devices fulfilling the ASSURED requirements suggested by the World Health Organization (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable). In this technique, natural enzymes are conventionally employed tags to provide bioreceptors such as antibodies with catalytic activity for quantitative assessment. Nonetheless, their inherent biomolecular limitations pose significant challenges, including cost and storage constraints. We propose an alternative conjugation for antibodies based on catalytic bimetallic nanoclusters and their integration in such simple colorimetric paper-based immunoassay. The nanoclusters are composed of gold and platinum and they are embedded in the structure of an anti-rabbit antibody, integrating in a single component the biorecognition and transduction elements required for biosensing. The detection is based on the catalytic properties of the NCs to oxidize an insoluble chromogenic substrate, generating a visible signal on the surface of the paper that can be further analysed for quantitative results. We demonstrate the detection of antibodies against the inflammation biomarker interleukin-6 with a limit of detection of 200 ng mL<sup>-1</sup>. Experimental results reveal improvements in terms of stability compared to the natural enzyme horseradish peroxidase, retaining most of its activity after a storage equivalent to 6 months at 4 °C. Additionally, incorporating the NCs within the antibody structure instead of attaching them <i>via</i> a covalent bond provides an enhanced sensitivity of 69.7%. This assay could be transferred to other specific antibodies to detect and quantify other analytes of interest.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}