Nanoscale Horizons最新文献_第2页

Boron atom incorporation into metal nanoparticles. 硼原子与金属纳米颗粒的结合。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-24 DOI: 10.1039/d5nh00332f

Jie Zhao, Fernando Buendia-Zamudio, Sergey M Kozlov

{"title":"Boron atom incorporation into metal nanoparticles.","authors":"Jie Zhao, Fernando Buendia-Zamudio, Sergey M Kozlov","doi":"10.1039/d5nh00332f","DOIUrl":"https://doi.org/10.1039/d5nh00332f","url":null,"abstract":"Boron can become unintentionally incorporated into transition metals during the reduction of metal salts with borohydride. The presence of boron at the surfaces of transition metals (TMs) such as Pd and Pt is known to significantly influence their catalytic properties. In this study, we employ density functional (DFT) calculations to investigate the thermodynamics and kinetics of boron incorporation into ∼1.5 nm particles and extended (111) surfaces of fcc-Co, Rh, Ir, Ni, Pd, Pt, Cu, Ag, Au, and Al. Our results reveal that boron exhibits high thermodynamic stability in interstitial subsurface sites on (111) surfaces and nanoparticles of Rh, Pt, and Pd. Unlike extended surfaces, metal nanoparticles (NPs) can also stabilize boron within the coordination environment of surface metal atoms, with such sites being particularly stable in Rh, Ir, and Ni nanoparticles. Furthermore, the energy barriers for B migration at NP edge sites from the surface to subsurface decrease to <0.5 eV (for all metals except Ir), and the migration barrier for boron incorporation into the in-surface sites is lower than 0.2 eV. Notably, B incorporation induces a shift in the d-band center of adjacent metal atoms, which indicates its pronounced impact on the catalytic activity of transition metals.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive catalytic compartments emerge from synergistic integration of DNA nanostructures and transient coacervates. 适应性催化室从DNA纳米结构和瞬态凝聚的协同整合中出现。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-23 DOI: 10.1039/d5nh00519a

Abhay Srivastava, Parth Kumar, Mathesh Punugusamy, Sourav Das, Subinoy Rana

{"title":"Adaptive catalytic compartments emerge from synergistic integration of DNA nanostructures and transient coacervates.","authors":"Abhay Srivastava, Parth Kumar, Mathesh Punugusamy, Sourav Das, Subinoy Rana","doi":"10.1039/d5nh00519a","DOIUrl":"https://doi.org/10.1039/d5nh00519a","url":null,"abstract":"Biomolecular condensates formed via liquid-liquid phase separation (LLPS) are essential to cellular organization, catalysis, and regulation of biochemical pathways. Inspired by such natural systems, we present a new adaptive coacervate formed by multivalent salt-bridge interactions of polyhexamethylene biguanide (PHMB) polymer and adenosine triphosphate (ATP). These phase separated compartments efficiently sequester guanine-rich DNA sequences that adopt G-quadruplex (GQ) conformations in the presence of potassium ions. Hemin intercalates into these GQ structures to produce a catalytically active DNAzyme with amplified peroxidase-like activity. Within the coacervate, reduced molecular diffusion and increased local substrate concentrations synergistically augment the catalytic efficiency of the DNAzyme by 10-fold compared to that in the unconfined state. Integrating an enzymatic degradation cycle by alkaline phosphatase allows ATP-fueled dissipative behavior of the coacervates. By integrating self-assembling catalytic motifs within a dissipative host environment, this system demonstrates key principles of spatially and temporally regulated catalysis, mimicking features of cellular microreactors. Our work highlights the potential of synthetic LLPS-based platforms as tunable and compartmentalized catalytic systems, with implications for biomimetic reactor design and the development of advanced functional materials.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the structural mechanics of ligated DNA crystals via molecular dynamics simulation. 通过分子动力学模拟了解结扎DNA晶体的结构力学。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-22 DOI: 10.1039/d5nh00524h

Yoo Hyun Kim, Anirudh S Madhvacharyula, Ruixin Li, Alexander A Swett, Seongmin Seo, Emile J Batchelder-Schwab, Naseem Siraj, Chengde Mao, Jong Hyun Choi

{"title":"Understanding the structural mechanics of ligated DNA crystals via molecular dynamics simulation.","authors":"Yoo Hyun Kim, Anirudh S Madhvacharyula, Ruixin Li, Alexander A Swett, Seongmin Seo, Emile J Batchelder-Schwab, Naseem Siraj, Chengde Mao, Jong Hyun Choi","doi":"10.1039/d5nh00524h","DOIUrl":"https://doi.org/10.1039/d5nh00524h","url":null,"abstract":"DNA self-assembly is a highly programmable method to construct arbitrary architectures based on sequence complementarity. Among various constructs, DNA crystals are macroscopic crystalline materials formed by assembling motifs via sticky end association. Due to their high structural integrity and size ranging from tens to hundreds of micrometers, DNA crystals offer unique opportunities to study the structural properties and deformation behaviors of DNA assemblies. For example, enzymatic ligation of sticky ends can selectively seal nicks resulting in more robust structures with enhanced mechanical properties. However, the research efforts have been mostly on experiments involving different motif designs, structural optimization, or new synthesis methods, while their mechanics are not yet fully understood. The complex properties of DNA crystals are difficult to study via experiments alone, and numerical simulation can complement and aid the experiments. The coarse-grained molecular dynamics (MD) simulation is a powerful tool that can probe the mechanics of DNA assemblies. Here, we investigate DNA crystals made of four different motif lengths with various ligation patterns (full ligation, major directions, connectors, and in-plane) using oxDNA, an open-source, coarse-grained MD platform. We found that several distinct deformation stages emerge in response to mechanical loading and that the number and the location of ligated nucleotides can significantly modulate structural behaviors. These findings should be useful for predicting crystal properties and thus improving the design.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celebrating ten years of Nanoscale Horizons. 庆祝纳米尺度地平线十周年。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-22 DOI: 10.1039/d5nh90054a

Katharina Landfester

引用次数: 0

Advances of nanopore sensors toward virus detection and diagnostic applications. 纳米孔传感器在病毒检测和诊断中的应用进展。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-19 DOI: 10.1039/d5nh00435g

Lingzhi Wu, Ke Qi, Wentao Yang, Guohao Xi, Jie Ma, Jing Tu

{"title":"Advances of nanopore sensors toward virus detection and diagnostic applications.","authors":"Lingzhi Wu, Ke Qi, Wentao Yang, Guohao Xi, Jie Ma, Jing Tu","doi":"10.1039/d5nh00435g","DOIUrl":"https://doi.org/10.1039/d5nh00435g","url":null,"abstract":"With the advantages of ultra-sensitivity and high throughput, nanopore technology has now evolved into a versatile tool for a wide range of practical applications, including genomic sequencing, proteomic analysis, and detection of various infectious and noninfectious diseases using biomarkers. Especially for infectious diseases, the rapid diagnosis of pathogenic microorganisms is a critical prerequisite for pandemic control and treatment. It is well known that the whole-genome sequences of some pandemic viruses have been accomplished to provide a high-resolution view of pathogen surveillance. This article reviews the progress of nanopore sensors towards virus detection and clinical applications, focusing on innovative strategies aimed at enhancing the detection efficiency. Intrinsically, the nanopore allows the single-molecule counting of viruses in nanofluidic channels. Some nucleic acid and protein components of the viruses are also potential target candidates for virus detection. Meanwhile, a variety of molecular probes involving aptamers, nucleic acids, peptides and nanoparticles have been designed to improve the detection sensitivity of target viruses. The stochastic sensing mode of nanopores further simplifies the conventional testing process, focusing on the rapid and qualitative identification of multiplex viruses, making it more feasible for portable, point-of-care diagnostics.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unambiguous calibration of power dependence in ratiometric luminescent nanothermometry through multiple intensity ratios and symbolic regression. 通过多强度比和符号回归对比例发光纳米热测量中功率依赖性的明确校正。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-18 DOI: 10.1039/d5nh00323g

Simon Spelthann, Lea Koetters, Rajesh Komban, Christoph Gimmler, Michael Steinke

{"title":"Unambiguous calibration of power dependence in ratiometric luminescent nanothermometry through multiple intensity ratios and symbolic regression.","authors":"Simon Spelthann, Lea Koetters, Rajesh Komban, Christoph Gimmler, Michael Steinke","doi":"10.1039/d5nh00323g","DOIUrl":"https://doi.org/10.1039/d5nh00323g","url":null,"abstract":"Ratiometric luminescence nanothermometry carries the potential to measure temperature in situations for which established methods are unsuitable. The precision of nanothermometry depends on the excitation power, so calibration and monitoring of the optical power is mandatory-a requirement that complicates optical setups and limits nanothermometry in scenarios where precise power control or measurement is impractical or unfeasible. Here, we use Er3+-activated nanothermometers and, besides the well-known 525/545 nm ratio, define a second luminescence intensity ratio involving the emission at 660 nm to achieve a power-calibration-free nanothermometry. The intensity of this emission is strongly correlated with the power and is available anyways when using standard spectroscopic instrumentation. We apply symbolic regression to find an unambiguous mathematical expression that describes the experimental data. From this mathematical expression, we determine the mean temperature deviation resulting from the fitting error to be 0.16 K and a maximum temperature precision as small as 6 mK (0.22 K on average). In summary, our approach makes excitation power measurements in ratiometric luminescent nanothermometry superfluous.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multilevel storage and linear optoelectronic response in mixed-dimensional photomemories. 混合维光电存储器中的多能级存储和线性光电响应。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-18 DOI: 10.1039/d5nh00397k

Chen-Yo Tsai, Dun-Jie Jhan, Che-Ming Wu, Ming-Pei Lu, Ming-Yen Lu

{"title":"Multilevel storage and linear optoelectronic response in mixed-dimensional photomemories.","authors":"Chen-Yo Tsai, Dun-Jie Jhan, Che-Ming Wu, Ming-Pei Lu, Ming-Yen Lu","doi":"10.1039/d5nh00397k","DOIUrl":"https://doi.org/10.1039/d5nh00397k","url":null,"abstract":"The rapid evolution of artificial intelligence (AI) computing demands innovative memory technologies that integrate high-speed processing with energy-efficient data storage. Here, we report a mixed-dimensional photomemory device based on a CsPbBr3/Al2O3/MoS2 architecture, leveraging perovskite quantum dots (PQDs) as a photoactive floating-gate layer, a tunable Al2O3 dielectric, and a 2D MoS2 channel. Optical and electrical characterization studies, including steady-state and time-resolved photoluminescence (PL), Kelvin probe force microscopy (KPFM), and current-voltage measurements, reveal the interplay of dielectric thickness and interfacial effects in governing charge transfer efficiency. By optimizing the Al2O3 thickness to 5.5 nm, we achieve precise control over charge transfer dynamics, enabling an optimal charge transfer rate with minimal optical energy (∼sub-pJ) to store a single positive charge in the PQDs. The device exhibits exceptional optoelectronic performance, including a nearly linear correlation between incident photon number and average photocurrent (Iph(avg)) over two orders of magnitude, multilevel storage capability, and a memory window with a high on/off ratio. These findings establish a robust platform for next-generation perovskite-based photomemories, offering insights into energy-efficient, high-performance optoelectronic systems for advanced AI chip applications.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancatalytic biomaterials enable inflammation-related disease intervention. 泛催化生物材料使炎症相关疾病干预成为可能。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-17 DOI: 10.1039/d5nh00408j

Xiaoyan Jiang, Yu Chen

{"title":"Pancatalytic biomaterials enable inflammation-related disease intervention.","authors":"Xiaoyan Jiang, Yu Chen","doi":"10.1039/d5nh00408j","DOIUrl":"https://doi.org/10.1039/d5nh00408j","url":null,"abstract":"Inflammatory disease (ID) is an umbrella term encompassing all conditions where both acute and chronic inflammation serve as the central pathogenic mechanism, imposing a profound global health burden due to the high morbidity, mortality, and socioeconomic impact of these conditions. These pathologies are unified by dysregulated inflammatory cascades, oxidative stress, and immune microenvironment imbalances, which drive progressive tissue damage and organ dysfunction. Conventional therapies, including immunosuppressants and anti-inflammatory agents, often provide only palliative relief, fail to address root causes, and carry the risk of systemic toxicity. The emerging pancatalytic biomaterial based approach, which involves the holistic management of preparation (P) of the catalyst, activation (A) of the biological effect and nontoxic treatment (N) of diseases, offers a transformative paradigm for precision management of ID. These pancatalytic biomaterials constitute the operational foundation of pancatalytic therapy, a multidisciplinary framework that integrates catalytic biomaterials with catalytic biology and catalytic medicine to systematically orchestrate pathological processes via the P-A-N framework, ultimately redefining therapeutic strategies from toxic therapy to nontoxic treatment. This review systematically investigates the rational design of pancatalytic biomaterials, classifying them into inorganic, organic, and organic/inorganic hybrid systems based on the composition. The therapeutic applications of pancatalytic biomaterials across cardiovascular, neurological, respiratory, sensory and other systems are comprehensively summarized. Finally, the current challenges in this field are discussed, and future developments and trends in employing pancatalytic biomaterials for inflammatory disease treatment are projected, thereby advancing further research and clinical translation.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous silicon biosensors meet zwitterionic peptides: tackling biofouling from proteins to cells. 多孔硅生物传感器满足两性离子肽：解决从蛋白质到细胞的生物污垢。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-17 DOI: 10.1039/d5nh00478k

Kayan Awawdeh, Xin Jiang, Lisa Dahan, Matan Atias, Janina Bahnemann, Ester Segal

{"title":"Porous silicon biosensors meet zwitterionic peptides: tackling biofouling from proteins to cells.","authors":"Kayan Awawdeh, Xin Jiang, Lisa Dahan, Matan Atias, Janina Bahnemann, Ester Segal","doi":"10.1039/d5nh00478k","DOIUrl":"https://doi.org/10.1039/d5nh00478k","url":null,"abstract":"Porous silicon (PSi)-based biosensors are promising platforms for label-free biomarker detection in complex environments, including potential in vivo applications, but their use remains limited due to their susceptibility to biofouling caused by their high surface area. Here, we address this challenge by covalently immobilizing zwitterionic peptides with glutamic acid (E) and lysine (K) repeating motifs onto PSi thin films. Systematic screening identified a specific sequence, EKEKEKEKEKGGC, which exhibited superior antibiofouling properties compared to conventional polyethylene glycol (PEG) coatings. This peptide effectively prevented nonspecific adsorption of biomolecules from complex biofluids, including gastrointestinal (GI) fluid and bacterial lysate. Applying this strategy to a PSi-based aptasensor for lactoferrin detection, we achieved more than one order of magnitude improvement in both the limit of detection and (LOD) and signal to noise ratio over PEG-passivated sensors, enabling sensitive detection in clinically relevant concentration ranges. The peptide's antibiofouling performance was also extended to biofilm-forming bacteria and adherent mammalian cells, underscoring its broad-spectrum protection against both molecular and cellular contamination. This universal strategy enhances the reliability of PSi biosensors by addressing a key cause of sensor failure in real-world applications.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proline stabilizes amphiphilic gold nanoparticles via hydrophobic interactions. 脯氨酸通过疏水相互作用稳定两亲性金纳米粒子。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-16 DOI: 10.1039/d5nh00260e

Ting Mao, Quy Ong, Joachim Kohlbrecher, Ekaterina Poliukhina, Paulo Jacob Silva, Francesco Stellacci

{"title":"Proline stabilizes amphiphilic gold nanoparticles via hydrophobic interactions.","authors":"Ting Mao, Quy Ong, Joachim Kohlbrecher, Ekaterina Poliukhina, Paulo Jacob Silva, Francesco Stellacci","doi":"10.1039/d5nh00260e","DOIUrl":"10.1039/d5nh00260e","url":null,"abstract":"Colloidal dispersions are key in many fields of science and technology. Recently, we have shown that small molecules can stabilize dispersions of nanoscale objects, such as proteins and nanoparticles by screening their net attractive interactions. This new effect is essentially the opposite of the well-known salt screening of electrostatic interaction. Here we show that small molecule stabilization of nanoparticles is a phenomenon strongly linked to the hydrophobic content of the particles as well as to the strength of their hydrophobic attraction. We compare the effect of proline on gold nanoparticles coated with 11-mercaptoundecane sulfonate (MUS) at varying percentages of the hydrophobic ligand octanethiol (OT). We show that the larger the percentage of OT, the larger the proline stabilization effect is. We also compare the effect of proline on water dispersions of nanoparticles with that on heavy water dispersions. In the latter, the hydrophobic effect plays a bigger role. We find that in D2O, proline stabilization is larger. We also compare the effect of proline on the same MUS:OT gold nanoparticles before and after an annealing process that is known to render the particle more hydrophilic. Proline is more effective on the particles before annealing. Finally, we study the effect of proline on non-aggregating allMUS nanoparticles. We find that proline stabilization of these particles is mainly due to a reduction in the long-range attraction coefficient. Overall, we show that proline stabilizes nanoparticle dispersions more effectively as the hydrophobic attraction between nanoparticles increases.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0