Nanoscale Horizons最新文献_第3页

DNA computing: DNA circuits and data storage. DNA计算：DNA电路和数据存储。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-15 DOI: 10.1039/d5nh00459d

Hang Xu, Yifan Yu, Peixin Li, Shaowei Liu, Xuehui Yan, Zhaoyu Zhou, Ye Tian

{"title":"DNA computing: DNA circuits and data storage.","authors":"Hang Xu, Yifan Yu, Peixin Li, Shaowei Liu, Xuehui Yan, Zhaoyu Zhou, Ye Tian","doi":"10.1039/d5nh00459d","DOIUrl":"https://doi.org/10.1039/d5nh00459d","url":null,"abstract":"Computation has consistently served as a significant indicator and direction of social development, and volume, speed, and accuracy are critical factors during development. To accelerate this computational process, various advanced technologies and constantly optimized computational methods have been developed, such as upgrading chip design and proposing quantum and photonic computing. Recently, DNA computing, as a unique computational model distinct from traditional methods, offers remarkable advantages and addresses problems that are difficult to solve with conventional computing. By designing DNA molecules and utilizing their spontaneous reactions, specific types of complex problems can be solved, such as combinatorial optimization, traveling salesman, Sudoku and other nondeterministic polynomial time (NP) problems. Based on the spontaneity of reactions, this type of computation exhibits high parallelism, making DNA computing a viable solution for high-complexity problems. This review presents an overview of the theoretical foundations of DNA computing and summarizes three distinct advantages to over traditional computing: high parallelism, efficient storage, and low energy consumption. Furthermore, based on these advantages, we assess the current state of development in two critical branches of DNA computing: DNA circuit and DNA information storage, and provide unique insights for the future development of DNA computing.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pattern and precision: DNA-based mapping of spatial rules for T cell activation. 模式和精度：基于dna的T细胞活化空间规则映射。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-11 DOI: 10.1039/d5nh00412h

Shujie Li, Kaltrina Paloja, Maartje M C Bastings

{"title":"Pattern and precision: DNA-based mapping of spatial rules for T cell activation.","authors":"Shujie Li, Kaltrina Paloja, Maartje M C Bastings","doi":"10.1039/d5nh00412h","DOIUrl":"https://doi.org/10.1039/d5nh00412h","url":null,"abstract":"The nanoscale spatial arrangement of T cell receptor (TCR) ligands critically influences their activation potential in CD8+ T cells, yet a comprehensive understanding of the molecular landscape induced by engagement with native peptide-MHC class I (pMHC-I) remains incomplete. Using DNA origami nanomaterials, we precisely organize pMHC-I molecules into defined spatial configurations to systematically investigate the roles of valencies, inter-ligand spacings, geometric patterns, and molecular flexibility in regulating T cell function. We find that reducing the inter-ligand spacing to ∼7.5 nm enhances T cell activation by up to eightfold compared to a wider spacing (∼22.5 nm), and that as few as six pMHC-I molecules are sufficient to elicit a robust response. Notably, the geometry of pMHC-I presentation emerges as a key determinant of signaling strength, with hexagonal arrangements proving most effective. In contrast, the introduction of flexible linkers into pMHC-I impairs TCR triggering. Together, these findings define spatial parameters that govern pMHC-I-TCR interactions at the T cell interface and provide design principles for engineering next-generation T cell-based immunotherapies.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA nanotechnology-enabled bioanalysis of extracellular vesicles. 细胞外囊泡的DNA纳米生物分析。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-11 DOI: 10.1039/d5nh00557d

Li Pan, Pengfei Wang

引用次数: 0

Ab initio perspectives on surface photocatalysis: advances, challenges, and opportunities. 表面光催化的从头开始：进展、挑战和机遇。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-11 DOI: 10.1039/d5nh00417a

Chang Gao, Youyou Tu, Zhan Shi, Lili Zhang, Weibin Chu, Qijing Zheng, Jin Zhao

引用次数: 0

Advances in the direct conversion of CH₄ and CO₂ into acetic acid over bimetallic catalysts supported on H-ZSM-5. H-ZSM-5负载双金属催化剂上CH4和CO2直接转化为乙酸的研究进展。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-11 DOI: 10.1039/d5nh00496a

Gabriel F Lopes, Alessandra F Lucrédio, Luiz H Vieira, Elisabete M Assaf

{"title":"Advances in the direct conversion of CH4 and CO2 into acetic acid over bimetallic catalysts supported on H-ZSM-5.","authors":"Gabriel F Lopes, Alessandra F Lucrédio, Luiz H Vieira, Elisabete M Assaf","doi":"10.1039/d5nh00496a","DOIUrl":"https://doi.org/10.1039/d5nh00496a","url":null,"abstract":"This study developed heterogeneous catalysts composed of ZnO and CeO2 supported on H-ZSM-5 for the direct conversion of methane (CH4) and carbon dioxide (CO2) into acetic acid. The acid-base and electronic properties were modulated through oxide impregnation and reduction, aiming to create active sites capable of simultaneously activating both reactants. The samples were characterized by XRD, N2 physisorption, HRTEM/EDS, NH3-TPD, CO2-TPD, TPR, FTIR, XPS, CO2-DRIFTS, and TGA, and tested in a batch reactor at 300 °C and 10 bar. The catalyst lifetime was evaluated through stability testing. The zeolite framework was preserved, although its properties were modified, resulting in improved CH4 and CO2 activation. The reduced catalyst exhibited a high surface area and an efficient distribution of acidic and basic sites, achieving an acetic acid productivity of 1473.40 µmol g-1 h-1 and a conversion rate of 35.12%. The results surpassed those of previous studies, highlighting the potential of the Zn-Ce/H-ZSM-5 system for biogas valorization and greenhouse gas mitigation.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-Chinese herbal medicines and their delivery strategies for central nervous system disease therapy. 纳米中草药及其在中枢神经系统疾病治疗中的递送策略。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-10 DOI: 10.1039/d5nh00277j

Yan Mu, Tong Jin, Tiantian Peng, Ya-Li Zhang, Jiameng Li, Rui Yu, Tiqiang Zhou, Guangchao Qing, Mengliang Zhu, Jianxin Chen, Qian Hua, Xing-Jie Liang

{"title":"Nano-Chinese herbal medicines and their delivery strategies for central nervous system disease therapy.","authors":"Yan Mu, Tong Jin, Tiantian Peng, Ya-Li Zhang, Jiameng Li, Rui Yu, Tiqiang Zhou, Guangchao Qing, Mengliang Zhu, Jianxin Chen, Qian Hua, Xing-Jie Liang","doi":"10.1039/d5nh00277j","DOIUrl":"https://doi.org/10.1039/d5nh00277j","url":null,"abstract":"Central nervous system (CNS) diseases, including neurodegenerative diseases, stroke, brain tumors, and others, result in poor quality of life and can cause substantial disability. Not all CNS diseases are amenable to surgical approaches, so drug development is important for disease treatment. Unfortunately, there are few drugs currently available for CNS diseases. Chinese herbal medicines (CHMs), represented by herb derived active ingredients and decoctions, have long been used in the treatment of CNS diseases. One of the major challenges in the further development of CHMs for CNS diseases is to improve cerebral drug delivery, and nanotechnology applied to CHMs to obtain nano-Chinese Herbal Medicines (nano-CHMs) is an effective way. This review categorizes nano-CHMs according to their preparation methods and sources, and discusses the applications of each nano-CHM and its advantages. Considering the special status of the brain, we further summarize the delivery strategies of nano-CHMs and the physiological barriers that need to be overcome for different strategies. Finally, we discuss the application of nano-CHMs for various CNS diseases, aiming to provide insights into the development of nano-CHMs for the treatment of CNS diseases.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmene nanosheets assembled from "plasmonic molecules". 由“等离子体分子”组装而成的等离子体纳米片。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-10 DOI: 10.1039/d5nh00381d

Qianqian Shi, Bo Fan, Xiaorui Cao, Debabrata Sikdar, Yifeng Huang, Jialiang Yin, Yan Lu, San H Thang, Wenlong Cheng

{"title":"Plasmene nanosheets assembled from \"plasmonic molecules\".","authors":"Qianqian Shi, Bo Fan, Xiaorui Cao, Debabrata Sikdar, Yifeng Huang, Jialiang Yin, Yan Lu, San H Thang, Wenlong Cheng","doi":"10.1039/d5nh00381d","DOIUrl":"https://doi.org/10.1039/d5nh00381d","url":null,"abstract":"Entropy-driven drying-mediated self-assembly of plasmonic nanocrystals (termed \"plasmonic atoms\") has emerged as a general strategy for fabricating plasmene nanosheets from a wide range of monodisperse nanocrystals. However, extending this approach to binary systems remains challenging due to the complex nanoscale interactions between dissimilar nanocrystal shapes. Here, we introduce a combined enthalpy- and entropy-driven strategy to achieve an orderly mixed two-dimensional (2D) binary nanoassemblies from complementary reacting polymer-ligated nanocrystals. Using nanocubes and nanospheres as model systems, \"plasmonic molecules\" were first synthesized via enthalpy interactions of different nanocrystals through stoichiometric reactions between complementary grafting polymers. This was followed by an entropy-driven, slow-drying-mediated assembly of \"plasmonic molecules\". This led to well-controlled binary plasmenes without phase separation. This method could be extended to a diverse range of other building block shapes and size scales. Our methodology indicates a new pathway for 2D nanocrystal assemblies with well-controlled mixing at nanoscale precision.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanostructured LiNi_0.80Co_0.15Al_0.05O₂ (NCA) for fast-charging, high-capacity battery cathodes. 用于快速充电、高容量电池阴极的纳米结构LiNi0.80Co0.15Al0.05O2 （NCA）。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-10 DOI: 10.1039/d5nh00290g

Victoria M Basile, Chun-Han Lai, Grace Y Kim, Christopher S Choi, Danielle M Butts, Kodi Thurber, Sophia C King, Sarah H Tolbert

{"title":"Nanostructured LiNi0.80Co0.15Al0.05O2 (NCA) for fast-charging, high-capacity battery cathodes.","authors":"Victoria M Basile, Chun-Han Lai, Grace Y Kim, Christopher S Choi, Danielle M Butts, Kodi Thurber, Sophia C King, Sarah H Tolbert","doi":"10.1039/d5nh00290g","DOIUrl":"https://doi.org/10.1039/d5nh00290g","url":null,"abstract":"Nanostructuring, which shortens lithium-ion diffusion lengths, can help facilitate pseudocapacitive behavior in some battery materials. Here, nanostructured LiNi0.80Co0.15Al0.05O2 (NCA), with porosity and decreased crystallite size compared to commercial bulk NCA, was synthesized using a colloidal polymer template. Small particles (∼150 nm) were obtained using rapid thermal annealing (RTA), while medium particles (∼300 nm) were obtained with conventional heating. X-ray photoelectron spectroscopy (XPS) was used to quantify surface Li2CO3 and NiO-like contaminants, which hinder lithium-ion diffusion, especially at fast rates. Electrochemical kinetics studies were used to quantify the benefits associated with nanostructuring. While all nanostructured samples displayed faster charge/discharge kinetics compared to the bulk materials, NCA with medium particle sizes showed the highest specific capacity at the fast rates (150 mAh g-1 at 16C). To explore full-cell behavior, nanostructured NCA was paired with a pseudocapacitive anode, achieving 95 W h kg-1 energy density at a current density of 1260 W kg-1 and stable cycling for 2000 cycles at 10C.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bionic nanomedicines for microwave-triggered cuproptosis to enhance cancer immunotherapy. 仿生纳米药物用于微波引发的铜增生，以增强癌症免疫治疗。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-09 DOI: 10.1039/d5nh00425j

Meng Suo, Ziqi Wang, Shiwei Zhang, Wei Tang, Dongyan Liang, Xiaoyuan Chen, Shipeng Ning

{"title":"Bionic nanomedicines for microwave-triggered cuproptosis to enhance cancer immunotherapy.","authors":"Meng Suo, Ziqi Wang, Shiwei Zhang, Wei Tang, Dongyan Liang, Xiaoyuan Chen, Shipeng Ning","doi":"10.1039/d5nh00425j","DOIUrl":"https://doi.org/10.1039/d5nh00425j","url":null,"abstract":"Cuproptosis relies on intracellular copper accumulation and shows great potential in tumor therapy. However, the high content of glutathione (GSH) in tumor cells limits its effectiveness. Furthermore, the mechanism of immune activation mediated by cuproptosis remains unclear. To address this, we developed a cancer cell membrane-coated Cu2O nanoparticle (TC) to induce cuproptosis in tumor cells. After entering tumor cells via homologous targeting, the TC released Cu2+ in the acidic microenvironment. Cu2+ are subsequently reduced to Cu+ generating hydroxyl radicals through the Fenton reaction. These results led to the downregulation of GSH and eventually sensitized cuproptosis. Microwave (MW)-induced hyperthermia further amplifies these effects. Experimental results demonstrate that TC + MW effectively induces 4T1 cancer cells' cuproptosis both in vitro and in vivo, significantly inhibiting 4T1 tumor growth with minimal systemic toxicity. The treatment also triggered tumor immunogenic cell death and sensitized T-cell-mediated anti-tumor immunity. TC offers a promising strategy for effective cancer cuproptosis and immunotherapy.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing two-photon molecular emitters in nanoparticle-on-mirror cavities. 镜面纳米粒子腔中双光子分子发射器的设计。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-08 DOI: 10.1039/d5nh00498e

S Smeets, B Maes, G Rosolen, C Van Dyck

引用次数: 0