ACS Nano最新文献

{"title":"Hyperuniform Mesoporous Gold Films Coated with Halogen-Bonding Metal-Organic Frameworks for Selective Raman Sensing of Chlorinated Hydrocarbons.","authors":"Sarah Z Khairunnisa,Olga Guselnikova,Yunqing Kang,Pavel S Postnikov,Rashid R Valiev,Jonathan P Hill,Nugraha Nugraha,Brian Yuliarto,Yusuke Yamauchi,Joel Henzie","doi":"10.1021/acsnano.5c09431","DOIUrl":"https://doi.org/10.1021/acsnano.5c09431","url":null,"abstract":"The selective detection of chlorinated aromatic hydrocarbons (CAHs) in environmental samples is challenging due to matrix interference effects. We report a surface-enhanced Raman spectroscopy (SERS) sensor that combines mesoporous Au films with UiO-66-I metal-organic framework (MOF) coatings to achieve the selective detection of CAHs. We show that mesoporous Au films can be considered hyperuniform two-dimensional (2D) materials where long-range correlations and local disorder assist in electromagnetic hotspot formation for SERS. Infiltrating the mesoporous Au films with UiO-66-I serves dual functions critical to sensor performance: First, its iodine-functionalized linkers selectively recruit CAHs from complex matrices through halogen bonding (HaB), concentrating target molecules at SERS hotspots while excluding common interferents. Second, the high refractive index of the MOF enhances light coupling by limiting scattered light, concentrating optical energy on the adsorbed CAHs for SERS enhancement. At optimal MOF thickness, the sensor achieves a detection limit below 1 × 10-10 M for 1,4-dichlorobenzene and 4-chlorobiphenyl, surpassing environmental standards by several orders of magnitude. The sensor demonstrates excellent selectivity for CAHs over common interferents, including protein, polycyclic aromatic hydrocarbons, and complex environmental matrices. Furthermore, the sensor maintains performance through multiple adsorption-desorption cycles, enabling reuse. This approach combines reticular chemistry with self-assembled nanostructured metals to achieve both high sensitivity and selectivity in complex environmental samples.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"244 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the Electronic Grab-Transport Mechanism to Construct Metal-Organic Frameworks with Type I/II Dual Sonodynamic Therapy Reinforcement.","authors":"Xiang Jiang,Lina Sun,Yuewu Zhao,Zhiyong Lu,Xuan He,Ying Xiang,Xingzhu Liu,Jine Wang,Renjun Pei","doi":"10.1021/acsnano.5c05276","DOIUrl":"https://doi.org/10.1021/acsnano.5c05276","url":null,"abstract":"Sonodynamic therapy (SDT) has demonstrated promising potential in the treatment of tumors and has attracted widespread attention. The majority of sound-sensitive materials developed to date have been categorized as oxygen-dependent type II sonosensitizers (SSs), which are susceptible to tumor hypoxia and significantly limit their efficacy. In this study, highly active porphyrin-based metal-organic frameworks (Yb-TCPP PMOF) with type I/II SDT dual actions were constructed by regulating the electron transfer process between metal nodes and ligands, which can produce multiple reactive oxygen species (ROS) such as 1O2, O2•-, and •OH. After that, the energy level barrier of triplet SSs was reduced by in situ loading of Au nanoparticles with the electronic grab-transport (EGT) effect, and the ROS yield was increased by accelerating the electron transport. Intriguingly, the successful construction of Au/Yb-TCPP not only produced abundant oxygen vacancy defects but also reduced the band gap, which effectively facilitated the electron-hole separation of SSs and further improved the SDT efficiency by inhibiting its recombination process. Furthermore, we also found that these ultrasmall Au nanoparticles in the MOF structure can act as catalase and undergo cascade reactions with glucose oxidase and obtain a self-producing oxygen circulation system (Au/Yb-TCPP@GOx) by reducing glucose through the coordination of nanoenzyme and bioenzyme. This not only significantly alleviates the hypoxia state of tumors but also has a starvation effect on tumor cells. Finally, it was verified at the levels of tumor cells and mice that Au/Yb-TCPP@GOx can effectively inhibit tumors through the dual effects of enhanced type I and type II SDT, as well as the starvation effect. The composite materials constructed showed a multisynergistic enhancement effect, which has guiding significance for improving electron transport, alleviating tumor hypoxia, enhancing ROS yield, and constructing starvation treatment strategies.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"25 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Situ Tumor Surface Modification with Antibody Fragments for Antigen-Independent Versatile Cancer Immunotherapy.","authors":"Seonwoo Kang,Yeoul Kang,Yelim Lee,Jaehyun Park,Junseok Lee,Won Jong Kim","doi":"10.1021/acsnano.5c08128","DOIUrl":"https://doi.org/10.1021/acsnano.5c08128","url":null,"abstract":"Natural killer (NK) cells exert potent cytotoxic effects by releasing perforin, granzyme B, and immune-boosting cytokines upon recognition of antibody-coated targets. However, the heterogeneous expression of tumor antigens poses a major limitation to NK-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). To overcome this challenge, we developed a Universal Antibody (Univody), a recombinant fusion protein that enables an antigen-independent presentation of Fc fragments on the surface of cancer cells. Specifically, the Fc region of human IgG1 was fused with a transmembrane domain and delivered in the form of plasmid DNA, ensuring stable membrane localization and interaction with NK cell receptors. For efficient and selective delivery, we employed a phenylboronic acid (PBA)-modified lipopolyplex (LPP-PBA), which significantly enhanced cellular uptake and transfection efficiency while reducing cytotoxicity. The plasmid DNA encoding Univody (pUnivody) effectively decorated a variety of heterogeneous tumor types with Fc fragments, leading to NK cell activation and enhanced immune responses in the tumor microenvironment. In vivo, pUnivody@LPP-PBA treatment resulted in marked tumor inhibition in both triple-negative breast cancer and melanoma models. This antigen-independent platform broadens the scope of antibody therapy and immunotherapy, offering a versatile approach to treating multiple types of cancers.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"706 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Honeycomb Organogel-Fabric for Osmotic Pressure-Driven Atmospheric Water Harvesting.","authors":"Zhihua Yu,Jing Su,Shuhui Li,Kaiying Zhao,Jichao Zhang,Xiaojie Liu,Diandian Zhang,Jianying Huang,Shaohai Fu,Yuekun Lai","doi":"10.1021/acsnano.5c06981","DOIUrl":"https://doi.org/10.1021/acsnano.5c06981","url":null,"abstract":"Atmospheric water harvesting (AWH) is a promising method to combat the challenge of water shortage. Despite the great progress of AWH, the imperfect structural design, complex fabrication procedures, and sluggish sorption/desorption kinetics hinder its AHW performance. Herein, a honeycomb organogel fabric (CHOF) with an interior osmotic pressure of 184.7 atm is reported. The calcium alginate skeleton was designed to accommodate hygroscopic glycerin solution, enabling the enhancement of water sorption of the CHOF. The interior osmotic pressure could refresh the sorption/desorption sites of the CHOF by continuously transporting the sorbed water from the surface to interior and the reverse, thus strengthening sorption/desorption kinetics. The honeycomb structure and loaded carbon black of CHOF could endow it with an effective solar-to-thermal performance for water desorption. Furthermore, based on the mature textile weaving technology, the CHOF was easy to be scaled up and did not show a decline of performance. The rapid sorption-desorption kinetics of CHOF was beneficial for daily multiple capture-release cycles. Ultimately, the daily water production of CHOF could achieve 6.70 kg m-2 day-1, which proves that the CHOF could be regarded as a sustainable material for large-scale water production.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"122 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quasi-Φ₀-Periodic Supercurrent at Quantum Hall Transitions.","authors":"Ivan Villani, Matteo Carrega, Alessandro Crippa, Elia Strambini, Francesco Giazotto, Vaidotas Mišeikis, Camilla Coletti, Fabio Beltram, Kenji Watanabe, Takashi Taniguchi, Stefan Heun, Sergio Pezzini","doi":"10.1021/acsnano.5c05294","DOIUrl":"https://doi.org/10.1021/acsnano.5c05294","url":null,"abstract":"<p><p>The combination of superconductivity and quantum Hall (QH) effect is regarded as a key milestone in advancing topological quantum computation in solid-state systems. Recent quantum interference studies suggest that QH edge states can effectively mediate a supercurrent across high-quality graphene weak links. In this work we report the observation of a supercurrent associated with transitions between adjacent QH plateaus, where transport paths develop within the compressible two-dimensional bulk. We employ a back-gated graphene Josephson junction, comprising high-mobility CVD-grown graphene encapsulated in hexagonal Boron Nitride (hBN) and contacted by Nb leads. Superconducting pockets are detected persisting beyond the QH onset, up to 2.4 T, hence approaching the upper critical field of the Nb contacts. We observe an approximate Φ₀ = <i>h</i>/2<i>e</i> periodicity of the QH-supercurrent as a function of the magnetic field, indicating superconducting interference in a proximitized percolative phase. These results provide a promising experimental platform to investigate the transport regime of percolative supercurrents, leveraging the flexibility of van der Waals devices.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetically Driven Living Microrobot Swarms for Aquatic Micro- and Nanoplastic Cleanup.","authors":"Su-Jin Song,Jeonghyo Kim,Roman Gabor,Radek Zboril,Martin Pumera","doi":"10.1021/acsnano.5c04045","DOIUrl":"https://doi.org/10.1021/acsnano.5c04045","url":null,"abstract":"Micro- and nanoplastic pollution is pervasive worldwide, infiltrating drinking water and food chains, accumulating in the human body, and posing serious threats to public health and ecosystems. Despite these urgent challenges, effective strategies to curb the widespread presence of micro- and nanoplastics have not yet been sufficiently developed. Here, we present magnetically driven living bacterial microrobots that exhibit a nature-inspired three-dimensional (3D) swarming motion, allowing the dynamic capture and retrieval of aquatic micro- and nanoplastics originating from various commercial products. By combining autonomous propulsion with magnetically guided navigation, we enabled the multimodal swarming manipulation of magnetotactic bacteria-based living microrobots (MTB biobots). The actuation of a rotating magnetic field induces a fish schooling-like 3D swarming navigation, allowing the active capture of micro- and nanoplastics, which are then retrieved from the contaminated water by magnetic separation. Our results show that the 3D magnetic swarming of MTB biobots synergistically enhances the removal efficiencies of both model and real-world microplastics, demonstrating their practical potential in water treatment technologies. Overall, plastic-seeking living bacterial microrobots and their swarm manipulation offer a straightforward and environmentally friendly approach to micro- and nanoplastic treatment, providing a biomachinery-based solution to mitigate the pressing microplastic pollution crisis.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"23 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering Carrier Thermalization, Relaxation, and Funneling in Mixed 3D/Quasi-2D CsPbI3 Perovskite Nanocrystals.","authors":"Kezhou Fan,Haochen Liu,Tianchen Pan,Ye Wu,Yulong Hai,Kunnathodi Vighnesh,Aleksandr A Sergeev,Jiaying Wu,Andrey L Rogach,Kam Sing Wong","doi":"10.1021/acsnano.5c06756","DOIUrl":"https://doi.org/10.1021/acsnano.5c06756","url":null,"abstract":"Harvesting the excess energy from hot carriers (HCs) represents a viable pathway to surpass the Shockley-Queisser limit in photovoltaic devices. However, such an approach faces challenges in bulk materials, where rapid energy dissipation competes with charge extraction. Promisingly, low-dimensional nanostructures, and in particular quasi-2D metal halide perovskite phases, can prolong HC cooling assisted by cascade energy transfer, whereas the physical mechanisms remain largely unknown. Here, we engineer HC thermalization, relaxation, and funneling dynamics in mixed 3D/quasi-2D CsPbI3 nanocrystals. We found a slow carrier thermalization of up to 0.9 ps in these materials due to the cascade energy transfer from the quasi-2D component. Both hot-phonon and funneling bottleneck effects augment the thermalization and hinder the energy cascade at higher carrier densities. Moreover, we tailor the energy cascade manifold by tuning the amount of the quasi-2D component, further retarding the funneling efficiency by ∼40% and thus preserving the excess energy from dissipation. This study reveals the intricate role of carrier funneling in HC relaxation kinetics, underscoring the prospect of low-dimensional perovskites for next-generation solar cell development.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"116 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electric Eel-Inspired Bioelectromechanical Bandage with Biochemical-Photothermal-Piezoelectric Synergy for Promoting Postoperative Recovery in Diabetes.","authors":"Xiaotong Wu,Shiqin Sheng,Yurui Xu,Jue Shi,Xinghai Ning,Anwei Zhou","doi":"10.1021/acsnano.5c07405","DOIUrl":"https://doi.org/10.1021/acsnano.5c07405","url":null,"abstract":"Shape-adaptive tissue-responsive adhesive patch (STRAP), inspired by the electric-eel's bioelectric capabilities, is proposed to enhance postsurgical recovery in diabetes. STRAP integrates piezoelectric nanogenerators, photothermal materials, and shape-adaptive fibers to address diabetes-related challenges, including impaired wound healing, infection susceptibility, and regeneration deficits. Its biochemical and photothermal properties promote tissue adhesion through covalent bonding and conformational adaptability, ensuring rapid hemostasis and preventing wound adhesions. STRAP replicates the natural microenvironment for effective regeneration and transforms mechanical energy from acoustic stress into beneficial electrical signals, boosting cellular activity, inhibiting bacterial infection, and accelerating wound repair. Preclinical evaluations across multiple animal models demonstrate STRAP's capacity to dynamically adapt to individual conditions and evolving environments, resulting in superior hemostatic performance in a pig liver injury model, postoperative adhesion prevention in the intestine and stomach, and wound healing acceleration in diabetic mouse, rat, and rabbit models. This underscores the promise of nature-inspired designs in tackling medical challenges. In summary, by integrating rapid hemostasis, infection control, tissue regeneration, and antiadhesion properties, STRAP provides a comprehensive solution for postoperative wound management and recovery.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"75 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Situ Polymerized Hybrid Nanofiber Membranes Boost High-Voltage Stability of Solid-State Lithium Metal Batteries.","authors":"Xinghui Liang,Mengrao Luo,Letian Chen,Haoyang Jiang,Zhendong Yang,Ruizheng Zhao,Xiaoping Lin,Xinyu Yu,Yirong Gao,Yue Zhang,Jinping Wei,Zhaojun Xie,Bin Tang,Zhen Zhou","doi":"10.1021/acsnano.5c07027","DOIUrl":"https://doi.org/10.1021/acsnano.5c07027","url":null,"abstract":"Solid-state lithium metal batteries, particularly those with solid polymer electrolytes, are regarded as promising solutions to achieve both higher energy density and safety. However, their development has been hampered by limited high-voltage tolerance. To overcome this challenge, we propose integrating a multifunctional hybrid nanofiber membrane with in situ polymerization of vinylene carbonate to create a solid electrolyte with exceptional high-voltage stability and efficient room-temperature performance. The improved compatibility and ionic conductivity arise from dipole-dipole interactions between polar groups and vinylene carbonate. Our approach delivers LiFePO4//Li cells with marvelous cycling stability, surpassing 1000 cycles at 1C, and especially shows excellent compatibility with high-voltage Li3V2(PO4)3 (4.8 V vs Li/Li+) and LiNi0.8Co0.1Mn0.1O2 (4.7 V vs Li/Li+). This straightforward yet effective strategy contributes to energy storage with safer and higher-energy-density solid-state lithium metal batteries.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"53 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conformational versus Configurational Entropy: Deciphering the Alkyl Chain-Dependent Membrane Attack Mechanism of Ionic Liquid Derivatives.","authors":"Xin You,Xuewei Dong,Wenqiang Tu,Bing Yuan,Kai Yang","doi":"10.1021/acsnano.5c10093","DOIUrl":"https://doi.org/10.1021/acsnano.5c10093","url":null,"abstract":"The escalating crisis of antibiotic resistance necessitates alternative antimicrobials like ionic liquid derivatives (ILDs), which target bacterial membranes, yet their structure-activity relationships remain elusive. Here, using all-atom molecular dynamics simulations combined with multiple analytical methods, including principal component analysis, Markov state modeling, and free-energy calculation/decomposition, we elucidate the fundamental mechanisms governing ILD-membrane interactions. Our simulations indicate a universal two-step mechanism involving initial membrane binding, followed by insertion. The ILD alkyl chain length serves as a critical determinant, modulating the conformational properties of monomers versus the configurational properties of aggregates. This structural control creates a thermodynamic dichotomy: monomer-membrane interactions are driven by conformational entropy, whereas aggregate-membrane interactions are governed by configurational entropy within a delicate entropy-enthalpy balance. These mechanistic insights not only reconcile experimental discrepancies but also offer guidance for the rational design. As a proof-of-concept, we demonstrate that membrane attack efficiency can be tuned by modulating alkyl chain rigidity/length or incorporating fullerene C60 into ILD aggregates. Collectively, our work provides a detailed mechanistic understanding to support the rational design of advanced ILD-based antimicrobial agents with tailored membrane-disrupting activities.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"278 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}