ACS NanoPub Date : 2025-04-28DOI: 10.1021/acsnano.5c01580
Chengang Pei, Nannan Li, Xiaotong Han, Wenfeng Zhou, Xu Yu, Jin Yong Lee, Wenwu Li, Yuanhua Ding, Ho Seok Park, Huan Pang
{"title":"Edge-Specific Confined Construction of an Interfacial Re–O–Co Bridge for Enhanced Trifunctional Electrocatalysis","authors":"Chengang Pei, Nannan Li, Xiaotong Han, Wenfeng Zhou, Xu Yu, Jin Yong Lee, Wenwu Li, Yuanhua Ding, Ho Seok Park, Huan Pang","doi":"10.1021/acsnano.5c01580","DOIUrl":"https://doi.org/10.1021/acsnano.5c01580","url":null,"abstract":"The limited abundance of edge sites in transition metal dichalcogenides (TMDCs) has hindered their utilization despite their superior electrocatalytic activity. Here, we propose an edge-oriented modification strategy by precisely confining ultrafine Co<sub>3</sub>O<sub>4</sub> nanoclusters on the edges of ReS<sub>2</sub> via interfacial Re–O–Co chemical bridging (Co<sub>3</sub>O<sub>4</sub>@ReS<sub>2</sub>). Unlike conventional surface modifications, this chemical bonding confinement enables selective edge growth, enhancing charge transfer and optimizing the electronic structure. Theoretical and experimental analyses reveal that the interfacial oxygen atoms act as active sites for the hydrogen evolution reaction (HER), facilitating H* adsorption via continuous gap states, while the spin-state transition of Co<sup>3+</sup> from low-spin to intermediate/high-spin improves oxygen intermediate adsorption, boosting the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR). As a result, Co<sub>3</sub>O<sub>4</sub>@ReS<sub>2</sub> exhibits outstanding trifunctional electrocatalytic performance, achieving low overpotentials of 76 mV for the HER and 260 mV for the OER at 10 mA cm<sup>–2</sup>, along with an ORR onset potential of 0.88 V. This study establishes an edge-site engineering approach for TMDC-based electrocatalysts, offering a promising pathway for enhancing energy conversion efficiency.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"81 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS NanoPub Date : 2025-04-26DOI: 10.1021/acsnano.5c0559510.1021/acsnano.5c05595
Qi Liang, Yunfei Bai, Kai Yao*, Chengwei Ye, Xiaoya Zhou, Yu Chen and Shaochun Tang*,
{"title":"Targeting Acceleration of the Rate-Determining Step in Sulfur Redox and Dendrite-Free Lithium: Heterointerface and Electron Structural Engineering","authors":"Qi Liang, Yunfei Bai, Kai Yao*, Chengwei Ye, Xiaoya Zhou, Yu Chen and Shaochun Tang*, ","doi":"10.1021/acsnano.5c0559510.1021/acsnano.5c05595","DOIUrl":"https://doi.org/10.1021/acsnano.5c05595https://doi.org/10.1021/acsnano.5c05595","url":null,"abstract":"<p >Currently, most catalysts for lithium–sulfur batteries suffer from some shortcomings, including restricted active sites and poor catalytic kinetics. Herein, we developed an advanced catalyst of V-MXene@octahedral porous carbon (MX@OPC), which features a “built-in interfacial electric field” (BIEF) and “dual-functional catalytic active sites” (DCASs), to target the accelerated rate-determining step in polysulfide redox kinetics and dendrite-free lithium behaviors. The well-designed heterointerface forms the BIEF due to the differences in work function and charge distribution, contributing to enhanced interfacial electron transfer and low lithium-ion diffusion barriers. The DCASs with superior Li<sub>2</sub>S<sub>4</sub> desorption efficiently catalyze the conversion from Li<sub>2</sub>S<sub>4</sub> to Li<sub>2</sub>S<sub>2</sub> by the distribution of relaxation times (DRT) analysis and density functional theory (DFT) calculations. The V-MXene exhibits strong lithophilicity, which facilitates uniform nucleation and dendrite-free growth of lithium. As a result, a battery with MX@OPC delivers a capacity fade rate per cycle as low as 0.017% over 1200 cycles at 2 C. Furthermore, MX@OPC renders a Li||Li symmetric cell to maintain a stable overpotential of 16 mV over 2500 h. This work provides inspiring insights into directed catalysis and generation of BIEF toward accelerating the rate-determining-step in sulfur redox and dendrite-free lithium deposition in Li–S batteries.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"19 17","pages":"17028–17039 17028–17039"},"PeriodicalIF":15.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS NanoPub Date : 2025-04-26DOI: 10.1021/acsnano.4c17748
Yifei Zhang, Kang Liu, Qing Sun, Yao Qi, Fang Li, Xiangchen Su, Mingzhu Song, Ruizhen Lv, Haijuan Sui, Yijie Shi, Liang Zhao
{"title":"Collagenase Degradable Biomimetic Nanocages Attenuate Porphyromonas gingivalis Mediated Neurocognitive Dysfunction via Targeted Intracerebral Antimicrobial Photothermal and Gas Therapy","authors":"Yifei Zhang, Kang Liu, Qing Sun, Yao Qi, Fang Li, Xiangchen Su, Mingzhu Song, Ruizhen Lv, Haijuan Sui, Yijie Shi, Liang Zhao","doi":"10.1021/acsnano.4c17748","DOIUrl":"https://doi.org/10.1021/acsnano.4c17748","url":null,"abstract":"<i>Porphyromonas gingivalis</i> (P.g.), a pathogen linked to periodontitis, is reported to be associated with severe neurocognitive dysfunction. However, there are few reports focusing on improving neurological function in the brain by eliminating P.g.. Therefore, we developed a core–shell nanocomposite for targeted intracerebral P.g. clearance and ameliorating neurocognitive impairments, Pt-Au@C-P.g.-MM, consisting of platinum nanoparticles (Pt NPs) encapsulated within Au nanocages (Pt–Au) as the core and a shell made of collagen and macrophage membranes from macrophage pretreated with P.g. (C-P.g.-MM). This design enhanced the nanocomposite’s ability to cross the blood–brain barrier (BBB) and specifically target intracerebral P.g. through coating of P.g.-MM. Pt-Au@C-P.g.-MM depended on collagen to neutralize excessive collagenase from P.g., promoting its directed migration toward P.g.. Au nanocages exhibited excellent photothermal effects under near-infrared (NIR) laser irradiation, while Pt NPs also provided an efficient antibacterial gas therapy by generating oxygen to expose anaerobic P.g.. As a result, Pt-Au@C-P.g.-MM contributed to a synergistic antibacterial therapy and significantly reduced P.g. mediated neurocognitive dysfunction in periodontitis mice induced by oral P.g. infection. Based on the insights provided by the transcriptome sequencing analysis, anti-P.g. activity of Pt-Au@C-P.g.-MM facilitated the transition of microglia from the M1 to M2 phenotype by stimulating the PI3K-Akt pathway and reducing neuronal damage through the Wnt/β-catenin pathway.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"867 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS NanoPub Date : 2025-04-26DOI: 10.1021/acsnano.4c1774810.1021/acsnano.4c17748
Yifei Zhang, Kang Liu, Qing Sun, Yao Qi, Fang Li, Xiangchen Su, Mingzhu Song, Ruizhen Lv, Haijuan Sui*, Yijie Shi* and Liang Zhao*,
{"title":"Collagenase Degradable Biomimetic Nanocages Attenuate Porphyromonas gingivalis Mediated Neurocognitive Dysfunction via Targeted Intracerebral Antimicrobial Photothermal and Gas Therapy","authors":"Yifei Zhang, Kang Liu, Qing Sun, Yao Qi, Fang Li, Xiangchen Su, Mingzhu Song, Ruizhen Lv, Haijuan Sui*, Yijie Shi* and Liang Zhao*, ","doi":"10.1021/acsnano.4c1774810.1021/acsnano.4c17748","DOIUrl":"https://doi.org/10.1021/acsnano.4c17748https://doi.org/10.1021/acsnano.4c17748","url":null,"abstract":"<p ><i>Porphyromonas gingivalis</i> (P.g.), a pathogen linked to periodontitis, is reported to be associated with severe neurocognitive dysfunction. However, there are few reports focusing on improving neurological function in the brain by eliminating P.g.. Therefore, we developed a core–shell nanocomposite for targeted intracerebral P.g. clearance and ameliorating neurocognitive impairments, [email protected], consisting of platinum nanoparticles (Pt NPs) encapsulated within Au nanocages (Pt–Au) as the core and a shell made of collagen and macrophage membranes from macrophage pretreated with P.g. (C-P.g.-MM). This design enhanced the nanocomposite’s ability to cross the blood–brain barrier (BBB) and specifically target intracerebral P.g. through coating of P.g.-MM. [email protected] depended on collagen to neutralize excessive collagenase from P.g., promoting its directed migration toward P.g.. Au nanocages exhibited excellent photothermal effects under near-infrared (NIR) laser irradiation, while Pt NPs also provided an efficient antibacterial gas therapy by generating oxygen to expose anaerobic P.g.. As a result, [email protected] contributed to a synergistic antibacterial therapy and significantly reduced P.g. mediated neurocognitive dysfunction in periodontitis mice induced by oral P.g. infection. Based on the insights provided by the transcriptome sequencing analysis, anti-P.g. activity of [email protected] facilitated the transition of microglia from the M1 to M2 phenotype by stimulating the PI3K-Akt pathway and reducing neuronal damage through the Wnt/β-catenin pathway.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"19 17","pages":"16448–16468 16448–16468"},"PeriodicalIF":15.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS NanoPub Date : 2025-04-26DOI: 10.1021/acsnano.4c1698510.1021/acsnano.4c16985
Min Jian, Xuan Ding, Qi Li, Yongye Zhao, Bo Wang*, Lijun Yang*, Lei Jiang and Jun Gao*,
{"title":"Artificial Proton Channel Membrane with Self-Amplified Selectivity for Simultaneous Waste Acid Recovery and Power Generation","authors":"Min Jian, Xuan Ding, Qi Li, Yongye Zhao, Bo Wang*, Lijun Yang*, Lei Jiang and Jun Gao*, ","doi":"10.1021/acsnano.4c1698510.1021/acsnano.4c16985","DOIUrl":"https://doi.org/10.1021/acsnano.4c16985https://doi.org/10.1021/acsnano.4c16985","url":null,"abstract":"<p >Proton channels have both high permeability and selectivity, a property that remains unparalleled by artificial materials yet is highly demanded in many applications, including acid recovery and power generation. This work takes inspiration from the structure and surface chemistry of biological proton channels and presents a method to construct covalent organic framework (COF) membranes consisting of high-performance artificial proton channels. The membrane was purposefully rendered amorphous, which eliminates most of the nanoscale pores and induces high steric hindrance to ions. On the other hand, the channels were functionalized with hydrogen-donating groups, allowing protons to hop fast. Interestingly, we found that the presence of hydrated protons causes additional hindrance to ions and thus self-amplifies the proton selectivity. Consequently, the proton selectivity against toxic heavy metal ions is up to 10<sup>4</sup>, significantly surpassing that of commercial acid-recovery membranes. The permeability is comparable to that of biological proton channels (a few mol m<sup>–2</sup> h<sup>–1</sup>). Such membranes allow us to recycle acid from industrial waste brines by a simple diffusion dialysis process without the risk of toxic ion leakage. At the same time, the entropy released by the proton diffusion can be harvested to generate power, achieving a power density superior to that of most previously reported membranes for osmotic energy harvesting.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"19 17","pages":"16405–16414 16405–16414"},"PeriodicalIF":15.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS NanoPub Date : 2025-04-26DOI: 10.1021/acsnano.4c16985
Min Jian, Xuan Ding, Qi Li, Yongye Zhao, Bo Wang, Lijun Yang, Lei Jiang, Jun Gao
{"title":"Artificial Proton Channel Membrane with Self-Amplified Selectivity for Simultaneous Waste Acid Recovery and Power Generation","authors":"Min Jian, Xuan Ding, Qi Li, Yongye Zhao, Bo Wang, Lijun Yang, Lei Jiang, Jun Gao","doi":"10.1021/acsnano.4c16985","DOIUrl":"https://doi.org/10.1021/acsnano.4c16985","url":null,"abstract":"Proton channels have both high permeability and selectivity, a property that remains unparalleled by artificial materials yet is highly demanded in many applications, including acid recovery and power generation. This work takes inspiration from the structure and surface chemistry of biological proton channels and presents a method to construct covalent organic framework (COF) membranes consisting of high-performance artificial proton channels. The membrane was purposefully rendered amorphous, which eliminates most of the nanoscale pores and induces high steric hindrance to ions. On the other hand, the channels were functionalized with hydrogen-donating groups, allowing protons to hop fast. Interestingly, we found that the presence of hydrated protons causes additional hindrance to ions and thus self-amplifies the proton selectivity. Consequently, the proton selectivity against toxic heavy metal ions is up to 10<sup>4</sup>, significantly surpassing that of commercial acid-recovery membranes. The permeability is comparable to that of biological proton channels (a few mol m<sup>–2</sup> h<sup>–1</sup>). Such membranes allow us to recycle acid from industrial waste brines by a simple diffusion dialysis process without the risk of toxic ion leakage. At the same time, the entropy released by the proton diffusion can be harvested to generate power, achieving a power density superior to that of most previously reported membranes for osmotic energy harvesting.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"3 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS NanoPub Date : 2025-04-26DOI: 10.1021/acsnano.5c05595
Qi Liang, Yunfei Bai, Kai Yao, Chengwei Ye, Xiaoya Zhou, Yu Chen, Shaochun Tang
{"title":"Targeting Acceleration of the Rate-Determining Step in Sulfur Redox and Dendrite-Free Lithium: Heterointerface and Electron Structural Engineering","authors":"Qi Liang, Yunfei Bai, Kai Yao, Chengwei Ye, Xiaoya Zhou, Yu Chen, Shaochun Tang","doi":"10.1021/acsnano.5c05595","DOIUrl":"https://doi.org/10.1021/acsnano.5c05595","url":null,"abstract":"Currently, most catalysts for lithium–sulfur batteries suffer from some shortcomings, including restricted active sites and poor catalytic kinetics. Herein, we developed an advanced catalyst of V-MXene@octahedral porous carbon (MX@OPC), which features a “built-in interfacial electric field” (BIEF) and “dual-functional catalytic active sites” (DCASs), to target the accelerated rate-determining step in polysulfide redox kinetics and dendrite-free lithium behaviors. The well-designed heterointerface forms the BIEF due to the differences in work function and charge distribution, contributing to enhanced interfacial electron transfer and low lithium-ion diffusion barriers. The DCASs with superior Li<sub>2</sub>S<sub>4</sub> desorption efficiently catalyze the conversion from Li<sub>2</sub>S<sub>4</sub> to Li<sub>2</sub>S<sub>2</sub> by the distribution of relaxation times (DRT) analysis and density functional theory (DFT) calculations. The V-MXene exhibits strong lithophilicity, which facilitates uniform nucleation and dendrite-free growth of lithium. As a result, a battery with MX@OPC delivers a capacity fade rate per cycle as low as 0.017% over 1200 cycles at 2 C. Furthermore, MX@OPC renders a Li||Li symmetric cell to maintain a stable overpotential of 16 mV over 2500 h. This work provides inspiring insights into directed catalysis and generation of BIEF toward accelerating the rate-determining-step in sulfur redox and dendrite-free lithium deposition in Li–S batteries.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"69 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS NanoPub Date : 2025-04-25DOI: 10.1021/acsnano.4c18613
Laura Perez-Chirinos, Lisa Almonte, Juan David Cortés-Ossa, Eduardo Solano, M. Reyes Calvo, Ivan R. Sasselli, Aitziber L. Cortajarena
{"title":"Tuning the Dimensionality of Protein–Peptide Coassemblies to Build 2D Conductive Nanomaterials","authors":"Laura Perez-Chirinos, Lisa Almonte, Juan David Cortés-Ossa, Eduardo Solano, M. Reyes Calvo, Ivan R. Sasselli, Aitziber L. Cortajarena","doi":"10.1021/acsnano.4c18613","DOIUrl":"https://doi.org/10.1021/acsnano.4c18613","url":null,"abstract":"The natural self-assembly tendency of proteins to build complex structural architectures has kindled inspiration in developing supramolecular structures through the rational design of biomacromolecules. While there has been significant progress in achieving precise control over the morphology of self-assembled structures, combining different molecules within assemblies enables the design of materials with increased complexity, sophisticated structures, and a broad spectrum of functionalities. Here, the development of 1D and 2D peptide–protein coassembled systems based on the design of amphiphilic peptides and engineered proteins is described. The peptide was optimized to form stable self-assembled fibers by evaluating, computationally and experimentally, the assembling tendencies and the supramolecular features of peptides with different lengths and negative charges. A superhelical repeat protein was engineered by fusing one or two amphiphilic peptides into one or both termini. This modification drove the coassembly between the self-assembled fibers and the protein with one or two peptides, resulting in 1D or 2D coassembled systems. The protein films and the 2D coassembled system exhibited high ionic conductivity for a biomolecular system, attributed to their high content of charged residues, positioning these materials as promising candidates for developing bioelectronic devices. Thus, this work provides a versatile framework for developing coassembled materials with tunable dimensionality by using biocompatible building blocks without any additional chemical moieties, highlighting the potential for their use in biocompatible electronics.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"63 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metal–Organic Frameworks Modified Organic Bulk Heterojunction Interfaces for Effective Nongenetic Neuromodulation","authors":"Kangkang Weng, Wenjun Li, Xinyu Cheng, Yunyun Xing, Xin Fu, Yinghan Wang, Huachun Wang, Xiaoli Tian, Yuqi Wang, Lizhu Li, Jun Yao, Xing Sheng, Jinghong Li, Hao Zhang","doi":"10.1021/acsnano.5c01516","DOIUrl":"https://doi.org/10.1021/acsnano.5c01516","url":null,"abstract":"Photoactive organic semiconductors, such as bulk heterojunctions (BHJs) of donor–acceptor pairs, are promising for building flexible devices for nongenetic and precise optical neuromodulation. However, the full potential of the diverse compositions and functionalities of BHJs has yet to be explored for neuromodulation due to their unsatisfactory interfaces with soft biotissues, which hinder signal transduction, tissue adhesion, and biocompatibility. Here, we address these challenges by introducing an interfacial layer composed of conductive and porous metal–organic frameworks (MOFs). The MOFs layer enhances charge injection capacity at the interface by >400 times and ensures tight and biocompatible junction between BHJs and biological materials. These improvements enable efficient electrical-to-ionic signal transduction for various BHJs, supporting reliable nongenetic modulation of cultured mouse hippocampal neurons under deep-red and near-infrared light. Moreover, flexible devices made from MOFs-modified BHJs allow for the <i>in vivo</i> stimulation of rat sciatic nerves at an ultralow light intensity threshold (0.01 mW mm<sup>–2</sup>), 700 times lower than that required for unmodified devices. This interfacial engineering with porous MOFs can expand the material toolbox of BHJs-based photocapacitors and unlock more functionalities for neuromodulation and prosthetic biointerfaces.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"38 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS NanoPub Date : 2025-04-25DOI: 10.1021/acsnano.5c00669
Austeja Staneviciute, Debora B. Scariot, Yu-Gang Liu, Yuan Qian, Swagat Sharma, El Hadji Arona Mbaye, Sultan Almunif, David M. Engman, Evan A. Scott
{"title":"Dual Treatment of Chronic Chagasic Cardiomyopathy and Parasitic Burden via Combination Nanotherapy","authors":"Austeja Staneviciute, Debora B. Scariot, Yu-Gang Liu, Yuan Qian, Swagat Sharma, El Hadji Arona Mbaye, Sultan Almunif, David M. Engman, Evan A. Scott","doi":"10.1021/acsnano.5c00669","DOIUrl":"https://doi.org/10.1021/acsnano.5c00669","url":null,"abstract":"In chronic Chagas disease, the persistence of the protozoan <i>Trypanosoma cruzi</i> (<i>T. cruzi</i>) is associated with an extensive inflammatory response that impacts cardiac function. The standard treatment, oral benznidazole, effectively targets the parasitic burden but does not address the chronic inflammation nor prevent the progression of severe cardiomyopathies. This presents an inherent immunotherapeutic challenge, as implementing an anti-inflammatory approach can have the unwanted effect of inhibiting beneficial parasite-specific immunity. Here, we investigated a combination therapy approach using benznidazole and immunomodulatory rapamycin-loaded poly(ethylene glycol)-<i>b</i>-poly(propylene sulfide) polymersome nanocarriers in a chronic Chagas disease murine model with cardiac abnormalities. The combined treatment demonstrated effective management of both inflammation and parasitic burden at systemic and local levels. No systemic reactivation of <i>T. cruzi</i> infection was observed, along with cardioprotective immunomodulatory effects through the modulation of cytokines, management of parasitic burden, and improved cardiac function based on electrocardiography assessment. The combination treatment enhanced a protective cytokine response in the heart, characterized by increased anti-inflammatory IL-10 levels, achieving greater effects than standard benznidazole treatment, and normalized TNF-α levels. Localized immunomodulatory effects, along with parasitic burden control, extended to other solid tissues relevant to parasite pathology and reservoirs. These findings highlight the therapeutic potential of modulating the immune response in chronic Chagas disease with rapamycin polymersomes and emphasize the importance of precise treatment timing in the strategy’s efficacy.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"8 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}