ACS Nano最新文献

{"title":"Enantiospecificity in Organic Photoelectrochemical Transistors Enabled by Chirality-Induced Spin Selectivity Effects.","authors":"Jian-Hong Zhu, Xinzhe Yang, Yulin Zheng, Shujia Wang, Zhen-Kun He, Zhida Gao, Yan-Yan Song","doi":"10.1021/acsnano.5c06982","DOIUrl":"https://doi.org/10.1021/acsnano.5c06982","url":null,"abstract":"<p><p>Chirality, as an intrinsic feature of the living world, is associated with many significant biological processes. Although the chiral-induced spin selectivity (CISS) effects have been recognized and applied to provide spin control over chemical reactions, their implementation in the organic electrochemical transistor (OECT) remains a largely unexplored area. Herein, the OECT technology is combined with a photovoltaic gate electrode and the CISS effect, establishing a chiral organic photoelectrochemical transistor (OPECT) for enantiomer identification. The chiral Sn(II)-based metal-organic framework (SnMOF)/SnO₂ hybrid, serving as a spin filter to induce CISS properties, is coated on a TiO₂ nanotube array-based photosensitive gate. Using cystine enantiomers as proof-of-principle, a target recognition-induced electron donor (l-/d-cysteine) generation was further proposed. The CISS effect enables a more efficient transfer of spin-polarized electrons between the L-target and L-gate (or between the D-target and D-gate), inducing a greater channel current (<i>I</i>_D) variation. The comprehensive analysis of the <i>I</i>_D responses in the two chiral OPECT sensors further enables accurate and reliable determination of the concentration and composition of enantiomers in unknown mixtures. This study provides a straightforward methodology to apply the CISS effect for determining chiral targets in complex samples.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid Metal Amplified Charge Separation in Photocatalytic Micro/Nanomotors for Antibacterial Therapy.","authors":"Zichang Guo,Dongdong Jin,Haohui Li,Xinyu Zhu,Tianqi Zheng,Zirong Xu,Yi Chen,Xiaojia Liu,Yinuo Song,Dai Wang,Xiaohui Yan,Xing Ma","doi":"10.1021/acsnano.5c03785","DOIUrl":"https://doi.org/10.1021/acsnano.5c03785","url":null,"abstract":"Photocatalytic micro/nanomotors (MNMs) driven by electrophoresis have attracted considerable attention by virtue of their active mobility and versatile functionality. However, the rapid recombination of photogenerated electron-hole pairs on light illumination severely compromises the involvement of charge species in the catalytic redox reactions of fuels, thus hindering both the propulsion and the application performance of photocatalytic MNMs. Herein, we report a facile strategy to amplify charge separation by incorporating liquid metal (LM) into the construction of photocatalytic MNMs, thereby strengthening the electrophoretic propulsion of MNMs and promoting the generation of reactive oxygen species (ROS) for antibacterial application. The MNMs are constructed with a gallium (Ga) LM core, coated with abundant graphite-phase carbon nitride (g-C3N4) nanosheets and half covered by a thin platinum layer. These MNMs exhibit self-propulsion in hydrogen peroxide (H2O2) solution, with their motion dynamics further enhanced by light irradiation. Theoretical calculations and simulations reveal that the composition between Ga and g-C3N4 forms an ohmic junction in the electronic energy band structure, which effectively improves the charge separation efficiency of electron-hole pairs. These results align well with the experimental electrochemical tests and consequently intensify the catalytic redox reactions of H2O2, as well as accelerate the charge migration across MNMs, contributing to the enhancement of their propulsion performance. Simultaneously, the amplified separation of electrons facilitates increased ROS generation, empowering the MNMs with motion-enhanced antibacterial activity against Escherichia coli. Finally, an in vivo wound healing experiment is conducted, verifying the superior antibacterial therapeutic performance of photocatalytic MNMs. This work not only provides insights into the role of charge species in phoretic motion of MNMs but also gives inspiration for developing photocatalytic MNMs with advanced biomedical applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"12 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144097684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charge Polarization-Enhanced Graphene Biosensors for the Attomole Detection of miRNA.","authors":"Feige Lou, Biyu Guo, Junhao Dai, Jiangyang Wang, Fangxuan Yi, Shuwen Shen, Chunxiao Cong, Guangxi Hu, Jingjing Jiang, Rui Zhang, Ye Lu","doi":"10.1021/acsnano.5c04479","DOIUrl":"https://doi.org/10.1021/acsnano.5c04479","url":null,"abstract":"<p><p>Due to graphene's structural and electrical properties, electrical biosensors made of this 2D material have drawn tremendous attention in the field of biosensing, enabling label-free, amplification-free, highly sensitive, and selective detection of diverse biological targets. However, the detection of biomolecules with minimal size and charge remains challenging due to the Debye electrostatic screening effect. This study introduces a surface chemistry treatment that employs fullerene derivatives to enhance charge transfer to the graphene biosensor interface, overcoming this limitation. Specifically, (1,2-methanofullerene C₆₀)-61-carboxylic acid (MFCA) is used as a linker molecule, replacing the traditional 1-pyrenebutanoic acid succinimidyl ester (PBASE). This modification facilitates the movement of electrons from biomarkers, such as microRNA (miRNA), across the Debye screening layer through a charge attraction effect. This approach achieves a detection limit (LoD) as low as 1 aM for hsa-mir-125b miRNA, a critical biomarker for Alzheimer's disease, and this is an improvement of 2-3 orders of magnitude over previous methods. The enhanced sensitivity is attributed to the efficient electron transfer from miRNA to the graphene surface, demonstrated by density functional theory (DFT) calculation and control experiment with the PBASE linker. Further, this method is also applied in the detection of another miR-34a with an ultralow LoD of 1 aM, showing its generalizability. This work enables the application of charge polarization-enhanced electrical biosensors in the early-stage diagnosis of various diseases with ultrahigh sensitivity.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Fractional Quantum Anomalous Hall Effect in Moiré Materials: Advances and Future Perspectives.","authors":"Jian Zhao,Le Liu,Yan Zhang,Haoran Zhang,Zexin Feng,Cong Wang,Shen Lai,Guoqing Chang,Bo Yang,Weibo Gao","doi":"10.1021/acsnano.5c01598","DOIUrl":"https://doi.org/10.1021/acsnano.5c01598","url":null,"abstract":"The search for anyons, quasiparticles with fractional charge and exotic exchange statistics, has inspired the research of condensed matter physics for decades. Moiré materials, as superlattice systems characterized by tunable isolated topological flat bands, represent a vast material library, with the ability to adjust properties via various tuning knobs, and show particular suitability for investigating the physics of anyons. In the study of Hall effects, Moiré systems offer a distinctive platform to achieve various Hall effects such as the valley Hall effect, nonlinear Hall effect, quantum anomalous Hall effect, and fractional quantum anomalous Hall effect (FQAHE). Particularly, over the nearly four decades from the discovery of the integer quantum Hall effect in 1980 to the observation of the FQAHE in 2023, research on Moiré materials has advanced the development of condensed matter physics rapidly. The discovery of FQAHE contributes to the study of non-Abelian quasiparticles, which holds potential for applications in topological quantum computing. This review primarily reviews the experimental advances brought about by the emergence of Moiré material systems on the path to achieving the FQAHE as well as the technological transformations driven by advancements in recent device fabrication techniques. Furthermore, we highlight the critical challenges and provide perspectives for future research.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"30 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatially Textured Strained Engineering of WSe2 on Dielectric Silk Fibroin for Enhanced Optoelectronic Performance.","authors":"Rui Wang,Zishun Li,Shunyu Chang,Zihan Li,Yue Liu,Nan Qin,Wen-Zhu Shao,Cheng-Yan Xu,Liang Zhen,Tiger H Tao,Yanquan Geng,Xiaorui Zheng,Yang Li","doi":"10.1021/acsnano.5c07017","DOIUrl":"https://doi.org/10.1021/acsnano.5c07017","url":null,"abstract":"Nanostrain patterning in two-dimensional transition metal dichalcogenides can enhance electrical and optoelectronic performance. However, from the viewpoint of device configurations, existing strategies cannot obtain controllable localized strain distribution with high-density integration capability nor effectively integrate with field effect transistors (FETs) for efficient electric field tunability. In this work, by leveraging both thermal scanning probe lithography and silk fibroin (SF), we achieved controllable nanostrain patterning in monolayer and bilayer WSe2 FETs for enhanced carrier mobility and photocurrent. First, we confirmed the presence of nanostrain and investigated its effect on the electronic structure and optical properties. Notably, bilayer WSe2 FET on SF dielectric exhibited enhanced carrier mobility after nanostrain patterning compared to pristine devices, attributed to strain-induced band gap narrowing and suppression of nonradiative recombination. Additionally, nanostrain reduced the binding energy of excitons and induced a built-in electric field, which drove electrons toward the strained area, facilitating trion formation and exciton multiplication. Consequently, the photocurrent was significantly enhanced in the patterned regions of the device, which can be efficiently tuned by electrostatic gating. These findings offer a blueprint for advanced nanoscale strain strategies aimed at miniaturizing and integrating multifunctional devices.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"54 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanosheets Derived from Titanium Diboride as Gate Insulators for Atomically Thin Transistors.","authors":"Anshul Rasyotra,Mayukh Das,Dipanjan Sen,Zhiyu Zhang,Andrew Pannone,Chen Chen,Joan M Redwing,Yang Yang,Kabeer Jasuja,Saptarshi Das","doi":"10.1021/acsnano.4c18634","DOIUrl":"https://doi.org/10.1021/acsnano.4c18634","url":null,"abstract":"Development and integration of gate insulators that offer a low equivalent oxide thickness (EOT) while maintaining a physically thicker layer are critical for advancing transistor technology as device dimensions continue to shrink. Such materials can deliver high gate capacitance and yet reduce gate leakage, thereby minimizing static power dissipation without compromising performance. These insulators should also provide the necessary interface quality, thermal stability, switching endurance, and reliability. Here, we demonstrate that nanosheets derived from titanium diboride (NDTD), synthesized at room temperature using a scalable dissolution-recrystallization method, exhibit EOT ∼ 2 nm irrespective of the physical thickness when used as top gate dielectrics for monolayer MoS2 field effect transistors (FETs). Furthermore, these nanosheets enable near-ideal subthreshold swing of 60 mV/decade, low gate leakage current (<10-4 A/cm2), and current on/off ratio of 106 at a supply voltage of 1 V, indicating clean interface and excellent electrostatic control. These titanium diboride (TiB2) derived nanosheet-gated MoS2 FETs also demonstrate stable operation at 125 °C and switching endurance in excess of 109 cycles. While nanosheets derived from metal diborides have been employed in energy storage, catalysis, and CO2 capture, this study showcases their potential as excellent gate insulators for microelectronics.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"126 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlated Lattice Fluctuations in CsPbBr3 Quantum Dots Give Rise to Long-Lived Electronic Coherence.","authors":"Arnab Ghosh,Albert Liu,Simon C Boehme,Patrick Brosseau,Dmitry N Dirin,Maksym V Kovalenko,Patanjali Kambhampati","doi":"10.1021/acsnano.5c03051","DOIUrl":"https://doi.org/10.1021/acsnano.5c03051","url":null,"abstract":"Electronic coherence is central to numerous areas of science, from quantum biology to quantum materials. In quantum materials, lead-halide perovskite (LHP) quantum dots (QDs) have been shown to support electronic coherence through observation of coherent single-photon emission and superfluorescence arising from spatial coherence at low temperatures. In contrast, direct measurement of temporal coherence between exciton states has been lacking. Here, we employ coherent multi-dimensional spectroscopy to observe an electronic coherence between exciton states in CsPbBr3 QDs that is long-lived at room temperature, surviving nearly three times longer than the electronic dephasing time. This observation of a long-lived electronic coherence at room temperature points to nearly perfectly correlated lattice fluctuations for each excitonic state in the superposition. These experiments reveal that the properties of LHP QDs extend to lattice dynamics that give rise to correlated fluctuations in the basis exciton states, a process that may next be optimized by design.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"132 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amphiphilic Carbon Dots for Ultrafast and Wash-Free Mitochondria-Targeted Imaging","authors":"Feishi Shan, Jing Zhang, Chengshuang Liao, Yanman Liu, Xiangli Li, Haodong Mi, Wei Wang, Shanshan Jiang, Mei Li, Yan-Hong Liu, Zhouyu Wang, Leyong Wang, Jun-Jie Zhu","doi":"10.1021/acsnano.5c05934","DOIUrl":"https://doi.org/10.1021/acsnano.5c05934","url":null,"abstract":"Carbon dots (CDs) exhibit exceptional biocompatibility and programmable amphiphilicity, establishing them as transformative nanomaterials for subcellular visualization with exceptional resolution. However, existing CD-based probes lack the spatiotemporal precision required for real-time organelle tracking, particularly in mitochondrial-targeted imaging via ultrafast, wash-free protocols. To overcome these limitations, this study describes the solvent-free, high-temperature (280 °C) and short-time (2 h) preparation of green-emitting CDs (GCDs) with distinctive amphiphilic architectures utilizing benzoylurea and citric acid in a sealed high-pressure reactor. GCDs may form micelle-like structures driven to hydrophobic interactions, producing long-wavelength emission in contrast to blue emission in low-polar solvents. They also simultaneously activate the synergy of numerous endocytotic modes, achieving ultrafast (&lt;5 s) and wash-free imaging. GCDs can also effectively target the mitochondria, more significantly, in both normal and cancer cells (Person’s value ≈ 0.90/0.91), which is explained by the minor adjustment of mitochondrial membrane potential. This work describes assembly mechanisms of amphiphilic CDs while establishing potential design principles for mitochondria-targeted nanostructures with wash-free, ultrafast tracking.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"79 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermosensitive Resiquimod-Loaded Lipid Nanoparticles Promote the Polarization of Tumor-Associated Macrophages to Enhance Bladder Cancer Immunotherapy","authors":"Haojie Shang, Ding Xia, Rui Geng, Jian Wu, Wen Deng, Yonghua Tong, Xiaozhuo Ba, Zichen Zhong, Yu He, Qiu Huang, Tao Ye, Xiaoqi Yang, Kehua Jiang, Ejun Peng, Jintao Zhu, Yijing Liu, Zhiqiang Chen, Kun Tang","doi":"10.1021/acsnano.4c17444","DOIUrl":"https://doi.org/10.1021/acsnano.4c17444","url":null,"abstract":"Bladder cancer is a common malignant tumor of the urinary system and is associated with high morbidity, recurrence, and mortality rates. Immunotherapy with immune checkpoint inhibitors has shown great therapeutic outcomes and safety in bladder cancer. Immune checkpoint inhibitors have also been approved as first- and second-line drugs for the treatment of locally advanced or metastatic bladder cancer. However, immunotherapy has a low response and drug assistance for cancer immunotherapy, which can be ascribed to insufficient antigen presentation, tumor immunosuppressive cell accumulation, and T lymphocyte exhaustion in the tumor microenvironment. To overcome the disadvantages of immunotherapy, we prepared a resiquimod (R848)/photothermal agent (DTPA)-loaded lipid nanoparticle (R848/DTPA@DSPE-PEG NP), which has shown good photothermal conversion efficiency, biosafety, and biocompatibility. R848/DTPA@DSPE-PEG NPs with laser irradiation (635 nm) can damage MB49 cells and induce immunogenic cell death in vitro, which could trigger an immune response. Meanwhile, R848/DTPA@DSPE-PEG NPs can also promote M1-like macrophage polarization and dendritic cell maturation in vitro. Moreover, R848/DTPA@DSPE-PEG NPs with 635 nm laser irradiation can suppress subcutaneous and orthotopic bladder tumor growth and activate the immune response, which can promote dendritic cell maturation and M1-like macrophage polarization, enhance CD8+ T lymphocyte infiltration, and reduce M2-like macrophage polarization in tumors. Bioinformatics analysis found that R848/DTPA@DSPE-PEG NPs can also induce immune-related gene overexpression of immune signaling pathways. Combined R848/DTPA@DSPE-PEG NPs with PD-1 antibody can significantly enhance antitumor therapeutic effects, reprogram tumor immunosuppressive microenvironment, and prolong the survival time.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"25 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering Circular Dichroism in the Nonlinear Optical Region with a Refractory Plasmonic Molybdenum Metasurface","authors":"Peng Yu, Tianji Liu, Yuxuan Zhu, Feng Lin, Shuai Yue, Junichi Takahara, Tao Ding, Hongxing Xu, Alexander O. Govorov, Zhiming M. Wang","doi":"10.1021/acsnano.5c05694","DOIUrl":"https://doi.org/10.1021/acsnano.5c05694","url":null,"abstract":"Chiral plasmonic metasurfaces exhibit circular dichroism (CD) and serve as a key tool for chiroptics. However, in the linear optical regime, the CD value remains fixed. Moreover, conventional chiral plasmonic metasurfaces suffer from poor photothermal stability, making it difficult to excite their nonlinear optical properties. Here, we present a refractory plasmonic molybdenum (Mo) metasurface that not only maintains strong chiroptical effects under extreme conditions, withstanding temperatures up to 1100 °C and laser intensities exceeding 12 GW/cm², but also realizes intensity-dependent tunable CD in the nonlinear optical region due to chiral saturated absorption and chiral reverse saturable absorption. In addition, our metasurface exhibits giant third-harmonic generation. Finally, we demonstrate a proof-of-concept circularly polarized light limiter based on this refractory chiral Mo metasurface.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"9 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}