ACS Nano最新文献

{"title":"Targeting the Immune-Neurovascular\u0000Interface to Ameliorate\u0000Pericyte Dysfunction with a Multifunctional Peptide–Drug Conjugate\u0000Nanoprodrug for Multiple Sclerosis Therapy","authors":"Yongkang Mu,Kaichao Wen,Lingling Zhou,Zhiyong Gu,Tianying Wang,Yixian Li,Xiyu Yang,Xuan Liu,Xinyi Zhang,Wenya Chi,Nianni Zhang,Peng Yang,Qizhi Zhang","doi":"10.1021/acsnano.6c11475","DOIUrl":"https://doi.org/10.1021/acsnano.6c11475","url":null,"abstract":"Abstract Pericyte dysfunction triggers blood–brain barrier (BBB) disruption and subsequent aberrant immune infiltration in multiple sclerosis (MS), yet targeted interventions remain lacking. Here, we engineered a dual-functional fusion peptide (VLC) for pericyte targeting and therapeutic intervention and subsequently conjugated it with luteolin to construct a peptide–drug conjugate (PDC)-based ROS-responsive nanoprodrug (VLC@Lut-NPs). This system significantly suppressed MMP-9 overactivation and mitigated neuroinflammation. To optimize the pharmacokinetic profile of the PDC nanotherapeutic, we adopted subcutaneous administration, achieving a prolonged circulation half-life and enhancing brain drug accumulation (AUCbrain) by 2.65-fold compared with intravenous injection. In two MS models, VLC@Lut-NPs restored pericyte homeostasis, reinforced BBB integrity, attenuated aberrant peripheral immune infiltration, and ultimately promoted myelin repair and regeneration. Notably, a once-every-other-day subcutaneous regimen outperformed daily intravenous administration. By bridging peripheral immunity and the neurovascular unit, this work identifies pericytes as a central regulatory node and establishes a pericyte-targeted PDC nanoplatform for durable MS treatment, highlighting its translational potential as a complementary strategy to conventional immunomodulatory approaches.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"9 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Ultrafast Excitation and Dephasing of Gap Plasmons into Hot Carriers in Structural Color Generation","authors":"Manobina Karmakar,&nbsp;Ayon Jyoti Karmakar,&nbsp;Aritra Biswas,&nbsp;Mahdi Soudi,&nbsp;Tianyi Guo,&nbsp;Pablo Cencillo-Abad,&nbsp;Prasanta Kumar Datta,&nbsp;Debashis Chanda","doi":"10.1021/acsnano.6c12999","DOIUrl":"10.1021/acsnano.6c12999","url":null,"abstract":"<p>Plasmon-induced hot-carriers generated through Landaudamping underpinapplications in plasmonic optoelectronics, energy conversion, andphotocatalysis. However, it remains unclear whether these carriersretain the spatial localization of their parent plasmon modes or rapidlylose this spatial memory through ultrafast scattering and transport.Here, we experimentally probe the spatial and temporal dynamics ofplasmon-induced hot-carriers in a strongly confined plasmonic structuralcolor consisting of disordered aluminum nanoparticle ensembles onnear-field cavities. Strong interparticle coupling produces hybridizedand localized gap plasmon modes with intense nanoscale electromagneticconfinement, which we directly visualize using scattering-type scanningnear-field optical microscopy. Ultrafast pump–probe measurementsselectively excite a homogeneously broadened sub-ensemble of plasmonicmodes, enabling indirect tracking of pump-generated, plasmon-inducedhot-carrier dynamics. We observe that hot-carriers undergo only partialspatial delocalization and retain signatures of the initial plasmoniclocalization for hundreds of picoseconds. The perturbed sub-ensemblereaches maximum line widths of 0.54 ± 0.06 eV (0.36 ± 0.05eV) under 630 nm (700 nm) excitation. On a phenomenological localizationscale from 0 (localized) to 1 (fully delocalized), this correspondsto 0.35 ± 0.10 and 0.09 ± 0.08 for 630 and 700 nm excitation,respectively. The wavelength-dependent fraction shows that the degreeof preserved localization is optically tunable, set by the carrierenergy. This persistence of spatial memory, likely arising from disorder-inducedscattering within the nanoparticle ensemble, reveals an unexpectedspatial dimension of hot-carrier dynamics and highlights the roleof plasmonic confinement and structural disorder in governing nanoscaleenergy flow, with implications for hot-carrier-based optoelectronics.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 40","pages":"27428–27438"},"PeriodicalIF":17.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Future of Nanoscience: Reaching Early-Career Scientists","authors":"Hyun-Wook Lee,&nbsp;Hyo Jae Yoon,&nbsp;Taeghwan Hyeon,&nbsp;Xiaodong Chen,&nbsp;Key Lee,&nbsp;Il-Doo Kim","doi":"10.1021/acsnano.6c17150","DOIUrl":"10.1021/acsnano.6c17150","url":null,"abstract":"","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 40","pages":"26845–26849"},"PeriodicalIF":17.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Space-Charge Layering in Ionic Covalent Organic Frameworks for Unidirectional Charge Transfer toward Efficient H2O2 Photosynthesis","authors":"Chao Yang,&nbsp;Jiamin Liu,&nbsp;Gaoyi Xie,&nbsp;Linxiao Hou,&nbsp;Huiyin Li,&nbsp;Jiahui Yan,&nbsp;Bin Wang,&nbsp;Li’an Hou","doi":"10.1021/acsnano.6c11167","DOIUrl":"https://doi.org/10.1021/acsnano.6c11167","url":null,"abstract":"<p>Solar-driven hydrogen peroxide (H₂O₂) productionover covalent organic frameworks (COFs) represents a promising sustainableparadigm, yet its efficiency is severely restricted by formidableexciton recombination. Herein, we employed a solvent-free melt polymerizationmethod to synthesize a highly crystalline <em>sp</em>² carbon-linked ionic COF, designated as TMB-COF-Br. IncorporatingN⁺-functionalized pyridine units constructed as electron-withdrawingcenters, a robust molecular space-charge layer was successfully engineeredwithin the pristine skeleton. The tailored electrostatic environmentfunctioned as an intramolecular charge-rectifying valve along the <em>sp</em>² carbon-linked conjugation, which significantlypromoted electron/hole dissociation and enabled directional chargetransport, thereby markedly boosting photocatalytic H₂O₂ production. Furthermore, the localized electropositive microenvironmenteffectively stabilized the crucial *OOH intermediate via electrostaticinteractions. Consequently, TMB-COF-Br achieved a remarkable H₂O₂ photosynthesis rate of 5770 μmol·g^–1·h^–1 at pH = 3 without anysacrificial agents, markedly outperforming the nonionized COF. Thiswork unveils the fundamental role of molecular space-charge layersin gating charge transfer in supramolecular systems, providing a powerfulparadigm for designing high-efficiency photocatalysts.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 40","pages":"27262–27273"},"PeriodicalIF":17.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth and Infrared Light Emission of Emerging van der Waals Semiconductors: Black Phosphorus and Tellurium","authors":"Junyong Wang,&nbsp;Jin Zhang,&nbsp;Shuo Zhang,&nbsp;Keyu Cheng,&nbsp;Kai Zhang","doi":"10.1021/acsnano.6c09378","DOIUrl":"https://doi.org/10.1021/acsnano.6c09378","url":null,"abstract":"<p>Infraredluminescent semiconductor materials and devices are fundamentalto optoelectronic information technology. van der Waals (vdW) semiconductors,notably black phosphorus (BP) and tellurium (Te), possess a narrowdirect bandgap and a low surface/Auger recombination rate, makingthem promising for infrared luminescence and light-emitting devices.The excitonic behavior and widely tunable band structure of such materialsoffer versatile pathways for modulating light emission, while theweak interlayer vdW interactions facilitate exceptional heterointegrationcapabilities. This review begins by addressing the challenges andrecent progress in the epitaxial growth of BP and Te thin films. Furthermore,we discuss excitonic near-infrared emission in few-layer BP, mid-infraredemitters derived from thicker BP, and Te-based mid-infrared luminescentdevices, along with their potential for spectral and polarizationtuning. Finally, key challenges and prospects in this evolving fieldare summarized.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 40","pages":"26850–26873"},"PeriodicalIF":17.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boosting Electron/Mass\u0000Transport via Interfacial Coupling\u0000in a Dual-Supported Catalyst toward Ampere-Level Hydrogen Evolution","authors":"Peng Wang,Meijun Liu,Tiantian Ma,Tong Sun,Weixuan An,Fengkai Liu,Nian Ran,Jianjun Liu,Wei Zhou","doi":"10.1021/acsnano.6c16356","DOIUrl":"https://doi.org/10.1021/acsnano.6c16356","url":null,"abstract":"Abstract Developing hydrogen evolution reaction (HER) electrocatalysts with high activity and long-term durability at industrial current densities remains challenging because catalytic kinetics, electron transport, and mass transport must be optimized simultaneously. Here, we report a one-pot method to anchor Pt-single-atom-modified NiCoP onto MXene with a high surface coverage of ∼97%. The Pt-NiCoP@MXene catalyst requires overpotentials of only 13.8 and 175 mV in 1 M KOH to deliver 10 and 1000 mA cm–2, respectively, and exhibits an ultralow decay rate of 7.1 μV h–1 over 1000 h at 1000 mA cm–2 in a three-electrode system. In an anion-exchange membrane electrolyzer, it achieves 1 A cm–2 at 1.74 V in a 4 cm2 cell with 98% voltage retention after 1000 h and maintains 97% retention over 500 h with a scaled 25 cm2 cell. Experiments and DFT calculations demonstrate the interface strong coupling via Ni/Co–O–Ti bonding bridges NiCoP and MXene effectively and accelerates the electron transport of catalytic layer, while the uniform dispersion of NiCoP on MXene improves surface wettability and facilitates bubble release and electrolyte replenishment. Additionally, Pt–P coordination increases the metallicity of Pt atoms and optimizes hydrogen adsorption/desorption. This work provides a facile strategy for synthesizing high-quality dual-supported catalysts and validates their industrial application potential.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"16 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bifunctional Nanozymes for Synergistic Treatment by Boosting Oxidative Stress and Regulating the Protein Kinase B Pathway","authors":"Qi Fang,&nbsp;Xiaojun Zhang,&nbsp;Chong-Bo Ma,&nbsp;Quanyi Liu,&nbsp;Jingyuan Yu,&nbsp;Jiaqi Li,&nbsp;Hao Sun,&nbsp;Jicheng Ma,&nbsp;Hui Wei,&nbsp;Yan Du","doi":"10.1021/acsnano.6c12630","DOIUrl":"10.1021/acsnano.6c12630","url":null,"abstract":"<p>Chemoresistance and dose-limiting toxicity remain majorchallengesin cancer chemotherapy, largely driven by aberrant activation of theprotein kinase B (AKT) survival pathway. Although small-molecule AKTinhibitors can enhance chemosensitivity, their systemic activity frequentlydisrupts normal metabolic processes and causes severe side effects.Here, we report an “all-in-one” catalytic nanodrug thatintegrates a dual-enzyme-mimicking nanozyme (GPMM) with doxorubicin(Dox) to overcome these limitations. GPMM simultaneously exhibitsperoxidase (POD)-like and phosphatase-like activities, enabling twosynergistic biochemical actions: (i) amplification of reactive oxygenspecies (ROS) through tumor-microenvironment-responsive catalyticconversion of endogenous hydrogen peroxide (H₂O₂), and (ii) depletion of intracellular nicotinamide adenine dinucleotide(NADH) to weaken antioxidant defenses. This dual modulation inducespersistent oxidative stress and leads to precise inhibition of AKTphosphorylation, functioning as an effective and safer alternativeto conventional AKT inhibitors. As a result, Dox@GPMM markedly enhanceschemosensitivity and suppresses tumor growth in nonresistant MCF-7breast cancer models, while the MUC1 aptamer-functionalized formulationAP-Dox@GPMM effectively reverses Dox resistance in MCF-7-ADR models,without observable systemic toxicity. RNA-sequencing analysis furtherreveals that the nanozyme regulates key genes involved in metabolism,survival, and AKT-related signaling, thereby reshaping cellular responseto chemotherapy. Collectively, this nanozyme-driven redox strategyprovides a robust and generalizable approach for boosting chemotherapeuticefficacy while minimizing adverse effects, offering strong translationalpotential for overcoming resistance across diverse tumor types.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 40","pages":"27390–27405"},"PeriodicalIF":17.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An NIR-II-Traceable Nanovaccine Programs Systemic Antigen Residence to Establish Checkpoint-Responsive Progenitor-Exhausted CD8-Positive T-Cell Reservoirs for Effective Cancer Immunotherapy","authors":"Muye Ma,&nbsp;Shiqiang Xie,&nbsp;Han Zhang,&nbsp;Haoran Ma,&nbsp;Tao Wang,&nbsp;Xinyue Wang,&nbsp;Zhihao Zhao,&nbsp;Huize Han,&nbsp;Yongliang Zhang,&nbsp;Jianjun He,&nbsp;Rui Tian,&nbsp;Wei Tang","doi":"10.1021/acsnano.6c12073","DOIUrl":"https://doi.org/10.1021/acsnano.6c12073","url":null,"abstract":"<p>Nanovaccines offer an opportunity to define where, howlong, andin which immune niches antigens are presented. However, many cancervaccine systems still preferentially induce transient effector CD8⁺ T-cell responses with limited capacity to sustain checkpoint-responsiveimmunity. Here, we report NIRVax, a second near-infrared window (NIR-II)-traceable,long-residence nanovaccine that couples real-time <em>in vivo</em> tracking to programmable systemic antigen residence. NIRVax is assembledfrom a triphenylamine-based NIR-II fluorophore and distearoyl phosphoethanolamine-polyethyleneglycol 2000 (DSPE-PEG₂₀₀₀), followed by covalent conjugationof the model protein antigen ovalbumin (OVA). After intravenous administration,NIRVax sustains antigen residence across secondary lymphoid organs(SLOs), with lymphoid signals peaking at day 4 postinjection followedby gradual clearance. This material residence profile enhances antigenuptake, dendritic cell maturation, and stem-like CD8⁺ T-cellgeneration. NIRVax also accumulates at bone-associated sites, whereit is associated with hematopoietic remodeling, myeloid-biased differentiation,and a reduced suppressive myeloid output. Functionally, systemic NIRVaxvaccination establishes antigen-specific progenitor-exhausted CD8⁺ T-cell (T_PEX) reservoirs across lymphoid tissuesand the tumor microenvironment (TME). Upon programmed death-ligand1 (PD-L1) blockade, these reservoirs are mobilized into effector CD8⁺ T-cell responses, leading to tumor immune remodeling, epitopespreading, and improved melanoma control. These findings establishspatiotemporal antigen residence as an engineerable biomaterial parameterfor shaping the CD8⁺ T-cell fate and provide a NIR-II-traceablenanovaccine strategy for potentiating checkpoint cancer immunotherapy.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 40","pages":"27372–27389"},"PeriodicalIF":17.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigating the Trade-Off between Bandgap Narrowing and Trap-Limited Transport for Low-Noise Organic Short-Wave Infrared Photodetectors","authors":"Ohhyun Kwon,&nbsp;Un-Hak Lee,&nbsp;Gyeong Min Lee,&nbsp;Seunghyun Oh,&nbsp;Se Jeong Park,&nbsp;Yeonsu Choi,&nbsp;Hyungju Ahn,&nbsp;Sang Heon Lee,&nbsp;Seunghyun Rhee,&nbsp;Dong Ryeol Whang,&nbsp;SungWoo Nam,&nbsp;Seo-Jin Ko,&nbsp;Jae Won Shim","doi":"10.1021/acsnano.6c10554","DOIUrl":"https://doi.org/10.1021/acsnano.6c10554","url":null,"abstract":"<p>Solution-processedorganic photodetectors present a promising routeto short-wave infrared detection; however, accessing the spectralregion beyond 1200 nm requires sub-1.0 eV organic absorbers, typicallyachieved through strong intramolecular charge transfer, enhanced quinoidalcharacter, and extended π-conjugation; whereas, conformationaland energetic disorder in such narrow-bandgap systems can contributeto trap-mediated transport losses and elevated dark current. Thisstudy introduces Fc2BS and Fc2BT, narrow-bandgap nonfullerene acceptorsdiffering solely in the π-bridge unit (benzoselenadiazole vsbenzothiadiazole), to examine how chalcogen substitution influencesbandgap narrowing and trap-related transport in sub-1.0 eV organicabsorbers. Fc2BS achieves an optical bandgap of 0.98 eV with absorptionextending to 1263 nm, where benzoselenadiazole substitution is associatedwith reduced structural and energetic disorder relative to benzothiadiazole.Compared to the Fc2BT-based device, the Fc2BS-based device suppressestrap density by 8-fold and extends the critical carrier transportlength by an order of magnitude, mitigating the dark current–responsivitytrade-off and achieving a dark current density of 7.88 × 10^–9 A cm^–2 with an EQE of 12.5% at1200 nm even at a low bias of −0.1 V, while enabling stablelow-bias operation through suppressed bias-dependent collection bottlenecksand dark current drift. A directly measured noise equivalent powerof 2.14 pW and corresponding specific detectivity of 1.47 × 10¹¹ cm·Hz^1/2·W^–1 at 1200nm highlight the benzoselenadiazole π-bridge as a promisingmolecular-design motif for extending SWIR response while limitingnoise and transport penalties.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 40","pages":"27235–27250"},"PeriodicalIF":17.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted Gastrointestinal Delivery of mRNA Lipid Nanoparticles Enables Systemic Vaccination and Glucagon-like Peptide-1 Metabolic Therapy","authors":"Abdulraouf M. Abbas,&nbsp;Ramy Ghanim,&nbsp;Sebastian Rudden,&nbsp;David Schultz,&nbsp;Bora Jang,&nbsp;Avraham Shakked,&nbsp;Hyejin Kim,&nbsp;James E. Dahlman,&nbsp;Alex Abramson","doi":"10.1021/acsnano.5c18549","DOIUrl":"https://doi.org/10.1021/acsnano.5c18549","url":null,"abstract":"<p>Lipid nanoparticles (LNPs) administered parenterallyoften showpoor localization to multiple tissue types, including the pancreasand gastrointestinal (GI) tract. Furthermore, patients typically preferorally administered drugs to those that are given parenterally. Wetherefore investigated whether GI LNP administration to buccal, gastric,small intestinal, colonic, and rectal submucosal tissues could simultaneouslycircumvent parenteral administration while enhancing LNP deliveryto previously inaccessible locations. We found that, in addition tolocal targeting, gastric LNP administration achieved an order of magnitudegreater pancreas delivery in rodents than intravenous administration.Gastric dosing of glucagon-like peptide-1 mRNA also improved bloodglucose regulation in mice compared with phosphate-buffered salinecontrols. Additionally, we found that buccal LNP administration targetedlocal and lymphatic tissues. Furthermore, dosing mice with ovalbuminmRNA resulted in equivalent immunoglobulin G blood titers to thoseof intramuscular delivery. These results suggest that GI administrationcan reprogram LNP biodistribution, expanding therapeutic opportunitiesfor both local and systemic nucleic acid delivery.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 40","pages":"26992–27001"},"PeriodicalIF":17.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}