ACS Nano最新文献_第9页

Room-Temperature Exciton-Polariton-Driven Self-Phase Modulation in Planar Perovskite Waveguides

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-01 DOI: 10.1021/acsnano.4c18847

Nikita V. Glebov, Mikhail A. Masharin, Alexei Yulin, Alexey Mikhin, Md Rumon Miah, Hilmi Volkan Demir, Dmitry N. Krizhanovskii, Vasily Kravtsov, Anton K. Samusev, Sergey V. Makarov

{"title":"Room-Temperature Exciton-Polariton-Driven Self-Phase Modulation in Planar Perovskite Waveguides","authors":"Nikita V. Glebov, Mikhail A. Masharin, Alexei Yulin, Alexey Mikhin, Md Rumon Miah, Hilmi Volkan Demir, Dmitry N. Krizhanovskii, Vasily Kravtsov, Anton K. Samusev, Sergey V. Makarov","doi":"10.1021/acsnano.4c18847","DOIUrl":"https://doi.org/10.1021/acsnano.4c18847","url":null,"abstract":"Optical nonlinearities are crucial for advanced photonic technologies since they allow photons to be managed by photons. Exciton-polaritons resulting from strong light–matter coupling are hybrid in nature: they combine the small mass and high coherence of photons with strong nonlinearity enabled by excitons, making them ideal for ultrafast all-optical manipulations. Among the most prospective polaritonic materials are halide perovskites since they require neither cryogenic temperatures nor expensive fabrication techniques. Here, we study strikingly nonlinear self-action of ultrashort polaritonic pulses propagating in planar MAPbBr3 perovskite slab waveguides. Tuning the input pulse energy and central frequency, we experimentally observe various scenarios of its nonlinear evolution in the spectral domain, which include peak shifts, narrowing, or splitting driven by self-phase modulation, group velocity dispersion, and self-steepening. The theoretical model provides complementary temporal traces of pulse propagation and reveals the transition from the birth of a doublet of optical solitons to the formation of a shock wave, both supported by the system. Our results presented here represent an important step in ultrafast nonlinear on-chip polaritonics in perovskite-based systems.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"15 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A One-Component Patchy-Particle Icosahedral Quasicrystal 单组分斑状粒子二十面体准晶体

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-01 DOI: 10.1021/acsnano.4c14885

Eva G. Noya, Jonathan P. K. Doye

引用次数: 0

Methylammonium-Free Perovskite Photovoltaic Modules

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-01 DOI: 10.1021/acsnano.4c18089

Liang Chu, Jinguo Cao, Congcong Wu

{"title":"Methylammonium-Free Perovskite Photovoltaic Modules","authors":"Liang Chu, Jinguo Cao, Congcong Wu","doi":"10.1021/acsnano.4c18089","DOIUrl":"https://doi.org/10.1021/acsnano.4c18089","url":null,"abstract":"For perovskite photovoltaic industrialization, it is essential to simultaneously achieve high conversion efficiency, long-term stability, and scalable fabrication of modules. Halide perovskites with the ABX3 structure are composed of A-site monovalent cations, (e.g., formamidinium (FA+), methylammonium (MA+), and Cs+), B-site divalent cations (predominantly Pb2+), and X-site halide anions. Though the incorporated MA cations can facilitate the nucleation and growth of perovskite films, their volatility undermines the thermal stability. α-FAPbI3 exhibits an optimal bandgap, but both it and α-CsPbI3 are susceptible to converting into the nonphotoactive δ-phase at room temperature. However, their FACsPbI3 alloy effectively counteracts the imperfections in the tolerance factor, enabling the formation of a room-temperature photoactive phase. Hence, the development of large-area, high-quality, and MA-free perovskite films remains a substantial challenge for efficient photovoltaic modules. This review first discusses the impact of A-site cations on the phase stability of perovskite structures and subsequently examines the film growth mechanism. Then, we summarize the MA-free perovskite photovoltaic modules and highlight advances in the CsPbX3 (Br–/I–), FAPbI3, and FACsPbX3 systems. Finally, we propose potential directions and challenges toward perovskite photovoltaic industrialization.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"58 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

tert-Butoxycarbonyl-Modification Driven Disturbance of Molecular Ordering Enables High-Efficiency Dual Drugs Co-Assembly for Synergistic Tumor Inhibition

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-01 DOI: 10.1021/acsnano.4c16986

Xuequan Zhang, Xiaoxian Zhang, Jiahui Zhu, Tinghua Li, Lianyi Yang, Lei Lei, Fang Wu, Bin He, Jun Cao

{"title":"tert-Butoxycarbonyl-Modification Driven Disturbance of Molecular Ordering Enables High-Efficiency Dual Drugs Co-Assembly for Synergistic Tumor Inhibition","authors":"Xuequan Zhang, Xiaoxian Zhang, Jiahui Zhu, Tinghua Li, Lianyi Yang, Lei Lei, Fang Wu, Bin He, Jun Cao","doi":"10.1021/acsnano.4c16986","DOIUrl":"https://doi.org/10.1021/acsnano.4c16986","url":null,"abstract":"The development of carrier-free drug delivery systems (CDDS) for tailored drug combinations posed a significant challenge, particularly in achieving efficient co-assembly while maintaining therapeutic efficacy. Herein, we proposed a co-assembly strategy based on molecular engineering. Paclitaxel (PTX) and 7-ethyl-10-hydroxycamptothecin (SN38) were chemically modified with tert-butoxycarbonyl (BOC) groups. The successful incorporation of the BOC groups was confirmed by proton nuclear magnetic resonance and mass spectrometry analyses. Further characterization using polarized light microscopy and X-ray diffraction revealed that this modification significantly reduced the crystallinity of both drugs, while simultaneously disrupting their original ordered stacking structure. Molecular dynamics simulations indicated that BOC modification increased molecular spacing, reduced stacking density, and expanded molecular volume, resulting in a looser molecular packing arrangement. This structural alteration enabled the modified drug molecules to efficiently coassemble with α-tocopherol succinate (α-TOS) into spherical nanoparticles at a nearly predefined mass ratio. The resulting nanoparticles exhibited a high drug loading capacity of 52.66% and remained stable at 4 °C for over 50 days. Notably, these nanoparticles displayed controllable release characteristics at pH 5.0. Both in vitro and in vivo studies demonstrated the BOC-modified drugs retained their bioactivity. When co-assembled with α-TOS, the nanoparticles exhibited a significant synergistic antitumor effect and suppressed tumor metastasis through downregulation of matrix metalloproteinase-9 (MMP-9) expression. This study provided a solid theoretical foundation and innovative approach for the development of CDDS, utilizing molecular-scale regulation for drug co-assembly.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"3 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ Metal–Organic Framework Growth in Serum Encapsulates and Depletes Abundant Proteins for Integrated Plasma Proteomics

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-01 DOI: 10.1021/acsnano.4c18028

Emily A. Reasoner, Hsin-Ju Chan, Timothy J. Aballo, Kylie J. Plouff, Seungwoo Noh, Ying Ge, Song Jin

{"title":"In Situ Metal–Organic Framework Growth in Serum Encapsulates and Depletes Abundant Proteins for Integrated Plasma Proteomics","authors":"Emily A. Reasoner, Hsin-Ju Chan, Timothy J. Aballo, Kylie J. Plouff, Seungwoo Noh, Ying Ge, Song Jin","doi":"10.1021/acsnano.4c18028","DOIUrl":"https://doi.org/10.1021/acsnano.4c18028","url":null,"abstract":"Protein biomarkers in human serum provide critical insights into various physiological conditions and diseases, enabling early diagnosis, prognosis, and personalized treatment. However, detecting low-abundance protein biomarkers is challenging due to the presence of highly abundant proteins that make up ∼99% of the plasma proteome. Here, we report the use of in situ metal–organic framework (MOF) growth in serum to effectively deplete highly abundant serum proteins for integrated proteomic analysis. Through biomolecule-mediated nucleation of a zeolitic imidazolate framework (ZIF-8), abundant plasma proteins are selectively encapsulated within ZIF-8 and removed from serum via centrifugation, leaving a depleted protein fraction in the supernatant. Bottom-up proteomics analysis confirmed significant depletion of the topmost abundant proteins, many at depletion levels exceeding 95%. Such depletion enabled the identification of 277 total proteins in the supernatant (uncaptured) fraction in a single-shot analysis, including 54 proteins that were only identified after depletion, 12 drug targets, and many potential disease biomarkers. Top-down proteomics characterization of the captured and uncaptured protein fractions at the proteoform-level confirmed this method is not biased toward any specific proteoform of individual proteins. These results demonstrate that in situ MOF growth can selectively and effectively deplete high-abundance proteins from serum in a simple, low cost, one-pot synthesis to enable integrated top-down and bottom-up proteomic analysis of serum protein biomarkers.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"15 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum Dot Interface-Enabled Cross-Coupling Acylation by Direct Aldehyde Activation under Visible Light

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-01 DOI: 10.1021/acsnano.5c01858

Xiao-Jun He, Zan Liu, Chao Zhou, Yang Wang, Li-Jun Zhang, Bin Chen, Xiao-Ning Guo, Chen-Ho Tung, Li-Zhu Wu

引用次数: 0

Single (002)-Textured Zinc Anode via Nonepitaxial Electrodeposition with In Situ Texture Maintenance for Stable Aqueous Zinc Batteries

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-01 DOI: 10.1021/acsnano.5c03597

Xiaotong Li, Wentao Yuan, Yue Wang, Xuewei Bao, Tongqiang Bi, Dingwen Cui, Zishuai Yang, Guoqiang Ma, Yuanyuan Wang, Zhaoxi Shen, Ning Zhang

{"title":"Single (002)-Textured Zinc Anode via Nonepitaxial Electrodeposition with In Situ Texture Maintenance for Stable Aqueous Zinc Batteries","authors":"Xiaotong Li, Wentao Yuan, Yue Wang, Xuewei Bao, Tongqiang Bi, Dingwen Cui, Zishuai Yang, Guoqiang Ma, Yuanyuan Wang, Zhaoxi Shen, Ning Zhang","doi":"10.1021/acsnano.5c03597","DOIUrl":"https://doi.org/10.1021/acsnano.5c03597","url":null,"abstract":"Crystallography regulation of a zinc (Zn) metal substrate to expose more (002) textures holds great promise for stabilizing Zn anodes. However, significant challenges remain in directly constructing a single (002)-plane-textured Zn metal anode (S-(002)-Zn) and realizing a sustainable (002)-texture exposure in working batteries. Herein, we report an anion and cation coregulated nonepitaxial electrodeposition to fabricate S-(002)-Zn by introducing 1-ethyl-3-methylimidazolium iodide (EmimI) additives in low-cost ZnSO4 aqueous electrolyte (ZS). Mechanistic studies reveal that the cooperation of Emim+ and I– with oriented adsorption behaviors on Zn can synergistically boost the (100) plane growth, depress the (002) plane growth, and suppress H2 evolution, thus enabling compact S-(002)-Zn electrodeposition. Moreover, other similar organic iodides (e.g., dimethyl-imidazolium iodide and 1-propyl-3-methylimidazolium iodide) are applicable to this scalable electrodeposition. On the other hand, the as-designed ZS-EmimI electrolyte can be directly applied in working Zn batteries, thus effectively sustaining the smooth (002) texture of S-(002)-Zn and inhibiting HER during cycling. Consequently, the combination of single-(002)-texture and ZS-EmimI electrolyte endows the S-(002)-Zn anode with an ultralong lifespan over 10,100 h (>14 months) at 1 mAh cm–2 and superior deep-cycling stability under 88.0% utilization (25 mAh cm–2) over 500 h and assures the stable operation of full Zn batteries.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"107 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly Distorted High-Entropy Alloy Aerogels for High-Efficiency Hydrogen Oxidation Reaction

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-01 DOI: 10.1021/acsnano.5c02198

Hanjun Li, Fulin Yang, Guanghua Wang, Liheng Guan, Feili Lai, Nan Zhang, Tianxi Liu

引用次数: 0

On-Surface Synthesis and Cryogenic Exfoliation of Sterically Frustrated Atropisomers

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-01 DOI: 10.1021/acsnano.4c16645

Philipp D’Astolfo, J.G. Vilhena, Simon Rothenbühler, Carl Drechsel, Oscar Gutiérrez-Varela, Robert Häner, Silvio Decurtins, Shi-Xia Liu, Giacomo Prampolini, Rémy Pawlak, Ernst Meyer

{"title":"On-Surface Synthesis and Cryogenic Exfoliation of Sterically Frustrated Atropisomers","authors":"Philipp D’Astolfo, J.G. Vilhena, Simon Rothenbühler, Carl Drechsel, Oscar Gutiérrez-Varela, Robert Häner, Silvio Decurtins, Shi-Xia Liu, Giacomo Prampolini, Rémy Pawlak, Ernst Meyer","doi":"10.1021/acsnano.4c16645","DOIUrl":"https://doi.org/10.1021/acsnano.4c16645","url":null,"abstract":"On-surface synthesis provides exceptional control over nanostructure and material composition, enabling the creation of molecular compounds that are difficult or impossible to obtain with other synthesis methods. In this work, we demonstrate the possibility of synthesizing atropisomeric molecules made of chains of polyaromatic hydrocarbon units via on-surface synthesis. Scanning probe microscopy reveals that molecules adsorbed on Au(111) surfaces adopt a planar structure, with adjacent monomeric units aligning either in parallel or antiparallel configurations, influencing the alignment of the molecule on the surface. Cryo-force spectroscopy peeling experiments show that metastable conformers can be mechanically stabilized during the lifting-redeposition process of the polymer from the surface. In this process, periodic drops in frequency shift are observed, corresponding to monomer detachment-readsorption. Interestingly, this periodicity is independent of the parallel/antiparallel configuration but is counterintuitively smaller than the monomer size. Molecular dynamics simulations relate this effective reduction in unit length to a tethering effect between the chain and the surface. This, in turn, allowed us to test and validate Silva’s analytical phenomenological power law model for peeling. Our findings not only provide a method for studying the elusive class 1 atropisomeric molecules but also offer deeper insight into the peeling phenomenon at the nanoscale.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"388 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transient Macrophage Depletion Circumvents Scavenging and Redirects Biodistribution of mRNA-Lipid Nanoparticles

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-01 DOI: 10.1021/acsnano.5c02001

Zhefan Yuan, Sijin Luozhong, Ruoxin Li, Wenchao Gu, Yu Chen, Dani Bhashyam, Rachel Lai, Shaoyi Jiang

{"title":"Transient Macrophage Depletion Circumvents Scavenging and Redirects Biodistribution of mRNA-Lipid Nanoparticles","authors":"Zhefan Yuan, Sijin Luozhong, Ruoxin Li, Wenchao Gu, Yu Chen, Dani Bhashyam, Rachel Lai, Shaoyi Jiang","doi":"10.1021/acsnano.5c02001","DOIUrl":"https://doi.org/10.1021/acsnano.5c02001","url":null,"abstract":"The mononuclear phagocytic system is recognized as a major scavenger of mRNA-lipid nanoparticles (LNPs), clearing and redirecting these particles away from their intended targets and thus diminishing their delivery efficacy. Understanding the mechanism by which mRNA-LNPs interact with phagocytes and how this interaction affects the mRNA transfection is critical to enhancing the delivery of mRNA. In this study, we temporarily depleted both circulating and resident macrophages (MF) and evaluated the transfection efficiency and biodistribution of mRNA-LNPs. We first demonstrated the enhanced liver expression using two liver-tropic formulations and the significant improvement of the in vivo gene editing efficiency of CRISPR-Cas9 in the Ai14 mouse model after MF depletion, providing a versatile strategy for enhanced mRNA delivery to the liver regardless of the formulation employed. We then extended our investigations to lung-tropic and lymphoid-tropic LNP formulations and discovered that MF depletion abolishes the targeting capacities of these non-liver-tropic formulations, providing insights into the organ targeting of LNPs. Finally, we screened and compared various clinically relevant MF depletion methods, providing the translation potential of this method on enhanced hepatic delivery of mRNA.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"55 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0