ACS Nano最新文献_第9页

An Ultrastrong and Ultraflexible Wood Veneer via Fiber Interaction Enhancement and Defect Reduction 通过纤维相互作用增强和减少缺陷的超强和超柔性木单板

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-01 DOI: 10.1021/acsnano.4c17158

Zhonglei Huang, Zhiru Cao, Yan-Feng Chen, Mingwei Zhu

{"title":"An Ultrastrong and Ultraflexible Wood Veneer via Fiber Interaction Enhancement and Defect Reduction","authors":"Zhonglei Huang, Zhiru Cao, Yan-Feng Chen, Mingwei Zhu","doi":"10.1021/acsnano.4c17158","DOIUrl":"https://doi.org/10.1021/acsnano.4c17158","url":null,"abstract":"Natural wood veneer is a flexible and sustainable material with significant potential for various applications. However, there are more defects in wood veneer, leading to lower strength, and the strengthening strategies currently used for wood blocks do not work well when applied to wood veneer. In this study, we processed the fragile wood veneer into an ultrastrong and ultraflexible material with a tensile strength of 578.4 MPa and preserved its beautiful wood texture. This enhancement is achieved by reducing defects within the veneer through adding cellulose molecules between the wood cell fibers. The resulting wood veneer is exceedingly flexible compared to natural wood, with a bending radius as small as 0.2 mm, while retaining its strength. This flexibility allows the veneer to be wrapped around other materials and improves the mechanical properties. The wood veneer exhibits much lower signal attenuation compared to carbon fiber fabric composites due to its electromagnetic transparency. Moreover, the environmental impact of producing each kilogram of this veneer is less than that of the carbon fiber material. These ultrastrong, ultraflexible, and sustainable properties of the wood veneer can enrich the family of lightweight, high-strength materials and enable a wide range of applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"91 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glioblastoma Cell Derived Exosomes as a Potent Vaccine Platform Targeting Primary Brain Cancers and Brain Metastases 胶质母细胞瘤细胞衍生外泌体作为针对原发性脑癌和脑转移瘤的有效疫苗平台

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-01 DOI: 10.1021/acsnano.4c14573

Yan Zou, Shanshan Li, Yundong Li, Dongya Zhang, Meng Zheng, Bingyang Shi

{"title":"Glioblastoma Cell Derived Exosomes as a Potent Vaccine Platform Targeting Primary Brain Cancers and Brain Metastases","authors":"Yan Zou, Shanshan Li, Yundong Li, Dongya Zhang, Meng Zheng, Bingyang Shi","doi":"10.1021/acsnano.4c14573","DOIUrl":"https://doi.org/10.1021/acsnano.4c14573","url":null,"abstract":"Glioblastoma multiforme (GBM) is the most prevalent brain tumor that remains incurable up to now. The rapid advancement of immunotherapy makes vaccines a promising therapeutic approach for GBM. However, current vaccine platforms, such as peptides, dendritic cells, mRNA, and viral vectors, are subject to limitations such as inadequate antigen loading, insufficient immune system activation, ineffective vector delivery, complicated fabrication process, and complex formulation. Here, we developed a GBM tumor cell derived homologous exosomal nanovaccine that does not need to carry any additional tumor antigens and leads to the activation of antigen-presenting cells (APCs) in lymph nodes, increasing the proportion of immune cells (matured dendritic cells, cytotoxic T cells, and memory T cells) and in turn promoting the expression of cytokines (TNF-α, IL-6, and IFN-γ), which effectively stimulates innate immunity to trigger durable protective immunity against tumor cell insult. Our nanovaccine platform possesses efficient dual-targeting capability to lymph nodes and the brain. More importantly, the developed exosomal nanovaccines protected 100% of treated mice by inducing sustained and strong immunity against GL261-luc GBM tumor cells, resulting in 100% mouse survival (8/8) up to 5 months. Our nanovaccines also induced antitumor immune responses in the immunosuppressed CT2A-luc GBM mouse model with greatly improved survival compared to control mice. Exosomal nanovaccines also demonstrated effectiveness in preventing brain metastasis in the B16F10-luc melanoma malignant brain metastasis mouse model, and the mice showed notably improved survival rates. Our simple and potent exosomes offer a versatile platform for clinical translation as individualized vaccine therapy.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"27 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical Evaluation of Presodiation Techniques for High Energy Sodium-Based Batteries 高能钠基电池预沉淀技术的实用评价

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-01 DOI: 10.1021/acsnano.5c02104

Kui Lin, Ming Liu, Xianying Qin, Guorui Zheng, Junwei Liang, Baohua Li, Chunhai Jiang

{"title":"Practical Evaluation of Presodiation Techniques for High Energy Sodium-Based Batteries","authors":"Kui Lin, Ming Liu, Xianying Qin, Guorui Zheng, Junwei Liang, Baohua Li, Chunhai Jiang","doi":"10.1021/acsnano.5c02104","DOIUrl":"https://doi.org/10.1021/acsnano.5c02104","url":null,"abstract":"Low-cost rechargeable sodium-based batteries are regarded as ideal alternatives to replace or complement current lithium-ion batteries in large-scale energy storage applications. Unfortunately, the commercial implementation of sodium-based batteries is restricted by their unsatisfied energy density, severe initial capacity decay, and discontented cycle life. Presodiation techniques including anode pretreatment and cathode additives are widely suggested to alleviate the above problems by providing an extra sodium resource to compensate for the initial capacity loss. However, none of them have been applied at the industrial level due to poor kinetics and severe gas evolution. Hence, in this timely review, we reclassify the presodiation techniques based on their operating locations and charge compensation mechanisms, which could provide intuitive perspectives for practical assessment. Key evaluation factors including kinetic performance, gas evolution behavior, environmental stability, and cost are proposed and systematically analyzed. The corresponding optimization strategies and potential applications are provided, followed by the scientific and technical challenges and suggestions for future industrialization. We believe this review will promote the industrial development of presodiation techniques in the future.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"59 1 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helical Perovskite Nanowires with Strong Circularly Polarized Luminescence Self-Assembled from Red-Emitting CsPbI3 Quantum Dots Following Chiral Ligand Exchange 手性配体交换后红发CsPbI3量子点自组装具有强圆极化发光的螺旋钙钛矿纳米线

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-01 DOI: 10.1021/acsnano.5c03149

Haochen Liu, Arsenii S. Portniagin, Bing Tang, Kunnathodi Vighnesh, Yun Li, Ye Wu, Daniil A. Rusanov, Lingyi Ke, Yunfan Wang, Ding Zhu, Desui Chen, Kwok-Chung Law, Maria V. Babak, Elena Ushakova, Andrey L. Rogach

{"title":"Helical Perovskite Nanowires with Strong Circularly Polarized Luminescence Self-Assembled from Red-Emitting CsPbI3 Quantum Dots Following Chiral Ligand Exchange","authors":"Haochen Liu, Arsenii S. Portniagin, Bing Tang, Kunnathodi Vighnesh, Yun Li, Ye Wu, Daniil A. Rusanov, Lingyi Ke, Yunfan Wang, Ding Zhu, Desui Chen, Kwok-Chung Law, Maria V. Babak, Elena Ushakova, Andrey L. Rogach","doi":"10.1021/acsnano.5c03149","DOIUrl":"https://doi.org/10.1021/acsnano.5c03149","url":null,"abstract":"Circularly polarized luminescence (CPL) of chiral perovskite nanocrystals is crucial for applications such as spin-polarized light-emitting diodes and chiral photodetectors. However, the reported luminescence dissymmetry factors are often too low for practical applications; it is also important for CPL wavelengths to cover the red emission range for display applications. Herein, we realized helical perovskite nanowires self-assembled from red-emitting CsPbI3 quantum dots (QDs) with a strong CPL signal around 640 nm, which was enabled by chiral ligand R-/S-binaphthyl phosphoric acid. The formation of CsPbI3 nanowires from perovskite QDs occurred by oriented attachment; QDs remaining in solution attached at the surface of the nanowires, forming helical structures. The films produced from these chiral nanowires demonstrate high dissymmetry factors of 1.1 × 10–2 and 2.3 × 10–2 for absorption and luminescence, respectively, surpassing many previously reported chiral nanomaterials. We employed multilayer nanowire films as chiral filters, generating left- and right-handed CPL.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"25 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inverse Design Method with Enhanced Sampling for Complex Open Crystals: Application to Novel Zeolite Self-assembly 复杂开放晶体的增强采样反设计方法：在新型沸石自组装中的应用

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-01 DOI: 10.1021/acsnano.4c17597

Chaohong Wang, Alberto Pérez de Alba Ortíz, Marjolein Dijkstra

{"title":"Inverse Design Method with Enhanced Sampling for Complex Open Crystals: Application to Novel Zeolite Self-assembly","authors":"Chaohong Wang, Alberto Pérez de Alba Ortíz, Marjolein Dijkstra","doi":"10.1021/acsnano.4c17597","DOIUrl":"https://doi.org/10.1021/acsnano.4c17597","url":null,"abstract":"Optimizing the design and synthesis of complex crystal structures presents pivotal opportunities and challenges in materials design. While recent computational advances in inverse design have proven effective for simpler crystals, their extension to intricate structures such as zeolites remains challenging. In this work, we introduce an efficient and robust inverse design workflow specifically tailored for the predictive design of a broad range of complex phases. By integrating an evolutionary parameter optimization strategy with enhanced sampling molecular dynamics simulations, this approach effectively surmounts the high energy barriers that typically hinder self-assembly in these complex structures. We apply this inverse design workflow to facilitate the efficient self-assembly of target zeolite frameworks in an efficient coarse-grained model of a tetrahedral network-forming component and a structure-directing agent. Using this method, we not only successfully reproduce the self-assembly of known structures like the Z1 and SGT zeolites and Type-I clathrates but also uncover previously unknown optimal design parameters for SOD and CFI zeolites. Remarkably, our approach also leads to the discovery of an uncatalogued framework, which we designate as Z5. Our methodology not only enables the screening and optimization of self-assembly protocols but also expands the possibilities for discovering hypothetical structures, driving innovation in materials design and offering a robust tool for advancing crystal engineering in complex systems.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"46 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenol-Mediated Electroactive Hydrogel with Armored Exosomes Delivery for Bone Regeneration 带装甲外泌体递送的多酚介导电活性水凝胶用于骨再生

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-01 DOI: 10.1021/acsnano.5c03256

Jingcheng Zheng, Jiachen He, Jianjun Wu, Yongle Yu, Yan Fu, Siwei Yin, Keyun Li, Yining Li, Limin Cai, Yikuan Du, Xiong Lu, Chaoming Xie

{"title":"Polyphenol-Mediated Electroactive Hydrogel with Armored Exosomes Delivery for Bone Regeneration","authors":"Jingcheng Zheng, Jiachen He, Jianjun Wu, Yongle Yu, Yan Fu, Siwei Yin, Keyun Li, Yining Li, Limin Cai, Yikuan Du, Xiong Lu, Chaoming Xie","doi":"10.1021/acsnano.5c03256","DOIUrl":"https://doi.org/10.1021/acsnano.5c03256","url":null,"abstract":"Prolonged oxidative stress and reduced activity of mesenchymal stem cells are significant barriers to effective bone repair. Current therapeutic approaches often suffer from limited long-term efficacy due to inefficient exosome delivery and the degradation of biological materials. Here, we present an electroactive gelatin methacryloyl hydrogel incorporating a tannic acid-mediated conductive polypyrrole microfiber network and exosomes armored with a metal-polyphenol network, designed to mitigate chronic inflammation and enhance bone healing. The iron-tannic acid complex forms a protective coating on the surface of exosomes, shielding them from damage in inflammatory environments and promoting osteoblast differentiation. This is achieved by enabling exosomes to evade lysosomal degradation through the proton sponge effect. Additionally, the phenolic hydroxyl groups of tannic acid effectively scavenge reactive oxygen species at injury sites. By delivering electrical stimulation to mimic the native electrophysiological environment, the catechol-quinone redox balance is maintained, providing sustained antioxidant effects. In a rat bone defect model, this multifunctional hydrogel demonstrated robust activity for bone regeneration. These findings demonstrated the ability of this electroactive hydrogel system to enhance exosome delivery, provide long-term antioxidative activity, and promote osteogenic differentiation, offering a promising therapeutic platform for bone tissue engineering.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"18 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upcycling Spent Cathodes from Li–Ion Batteries into a High-Entropy Alloy Catalyst with Reverse Electron Transfer for Li–O2 Batteries 锂离子电池废阴极升级改造成Li-O2电池反电子转移高熵合金催化剂

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-30 DOI: 10.1021/acsnano.5c00704

Peng Wang, Shan Guo, Yongbin Xu, Xinyi Yuan, Yu Tian, Binchao Xu, Zhijun Zhao, Yuxiao Wang, Jianwei Li, Xiaojun Wang, Zhiming Liu

{"title":"Upcycling Spent Cathodes from Li–Ion Batteries into a High-Entropy Alloy Catalyst with Reverse Electron Transfer for Li–O2 Batteries","authors":"Peng Wang, Shan Guo, Yongbin Xu, Xinyi Yuan, Yu Tian, Binchao Xu, Zhijun Zhao, Yuxiao Wang, Jianwei Li, Xiaojun Wang, Zhiming Liu","doi":"10.1021/acsnano.5c00704","DOIUrl":"https://doi.org/10.1021/acsnano.5c00704","url":null,"abstract":"Traditional recovery of valuable metals from spent ternary lithium-ion batteries concentrates on complicated pyrometallurgy and hydrometallurgy routes. Direct reutilization of these valuable used metals to catalyze Li–O2 batteries is highly appealing yet remains a significant challenge. Here, we report a general synthesis of ultrafine αNiCoMn (α = Pt, Ir, Ru) high-entropy alloy (HEA) nanoparticles anchored on a nitrogen-doped carbon (N–C) support through a facile one-step Joule heating, which serves as a high-efficiency catalyst for Li–O2 batteries. Solution alloying of recycled NiCoMn with Pt group metals facilitates catalytic efficiency through 3d–5d electronic interactions and the high-entropy assembly effect. Both experimental and calculation results reveal that, driven by rapid, nonequilibrium thermal shock, electron transfer defies conventional expectations, where the electrons are inclined to transfer from the higher electronegative Pt to the surrounding NiCoMn atoms. This interesting reverse local charge redistribution and orbital hybridization endow Pt with an elevated d-band center and an optimized electronic structure. The induced high-entropy coordination effects further generate highly active catalysis surfaces, favoring the adsorption of LiO2 intermediates and facilitating rapid decomposition kinetics of nanoscale Li2O2 products. These advantages endow Pt HEA@N–C with superior bifunctional catalytic activity, achieving an ultralow polarization of 0.27 V and a significantly enhanced cycling life of 240 cycles. We anticipate that this work will provide further insights into upcycling spent valuable metals for constructing efficient HEA electrocatalysts.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"71 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Kupffer Cell Metabolic Rewiring: Rapamycin–Gliadin Nanoparticle as a Pivotal Strategy for Immune Tolerance in Celiac Disease 利用Kupffer细胞代谢重组：雷帕霉素-麦胶蛋白纳米颗粒作为乳糜泻免疫耐受的关键策略

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-30 DOI: 10.1021/acsnano.4c18354

Xiaohan Jiang, Min Wang, Ruihan Zou, Min Fu, Wentao Fan, Yao Wang, Chenguang Dai, Zaman Swapnil, Wanjun Wang, Hao Wu, Kunxin Xie, Li Liu, Yan Wang, Zhining Fan, Lili Zhao

{"title":"Harnessing Kupffer Cell Metabolic Rewiring: Rapamycin–Gliadin Nanoparticle as a Pivotal Strategy for Immune Tolerance in Celiac Disease","authors":"Xiaohan Jiang, Min Wang, Ruihan Zou, Min Fu, Wentao Fan, Yao Wang, Chenguang Dai, Zaman Swapnil, Wanjun Wang, Hao Wu, Kunxin Xie, Li Liu, Yan Wang, Zhining Fan, Lili Zhao","doi":"10.1021/acsnano.4c18354","DOIUrl":"https://doi.org/10.1021/acsnano.4c18354","url":null,"abstract":"Celiac disease (CeD), triggered by gliadin exposure, necessitates therapeutic strategies that establish an antigen-specific immune tolerance. This study explores the therapeutic efficacy and mechanism of rapamycin–gliadin composite nanoparticles (PLN-GR) for CeD treatment. In vivo analyses demonstrated the efficient uptake of PLN-GR by antigen-presenting cells (APCs), particularly Kupffer cells and splenic dendritic cells (DCs), driving their tolerogenic phenotypic transformation. In a murine CeD model, PLN-GR administration significantly enhanced gluten tolerance and mitigated intestinal inflammation, as indicated by reduced paw edema and improved histopathological parameters. Mechanistically, PLN-GR induced macrophage metabolic reprogramming from glycolysis to oxidative phosphorylation, concomitant with elevated serum itaconate levels. This metabolic shift potentiated interorgan immunoregulatory crosstalk, expanding PD-L1+ tolerogenic splenic DCs while suppressing pathogenic Th1 cell populations. Bone marrow-derived macrophages (BMDMs) from Acod1–/– mice (deficient in itaconate synthesis) failed to induce DC tolerance upon PLN-GR treatment. However, supplementation with the itaconate derivative 4-octyl itaconate (4-OI) restored PD-L1 expression in DC2.4 cells in vitro, revealing that itaconate induces and stabilizes the tolerant DC phenotype. These findings underscore PLN-GR as a novel nanotherapeutic platform for CeD, achieving gliadin-specific tolerance through hepatic–splenic immunometabolic reprogramming and itaconate-dependent PD-L1 regulation, thereby offering a translatable strategy for autoimmune disease management.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"91 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Affinity Modifications of Porous Microscaffolds Impact Bone Regeneration by Modulating the Delivery Kinetics of Small Extracellular Vesicles 多孔微支架的亲和修饰通过调节细胞外小泡的递送动力学影响骨再生

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-30 DOI: 10.1021/acsnano.5c03297

Yike Gao, Xiaojing Yuan, Ruoheng Gu, Nan Wang, Huihui Ren, Rui Song, Zhuo Wan, Jianyong Huang, Kaikai Yi, Chunyang Xiong, Zuoying Yuan, Yuming Zhao

{"title":"Affinity Modifications of Porous Microscaffolds Impact Bone Regeneration by Modulating the Delivery Kinetics of Small Extracellular Vesicles","authors":"Yike Gao, Xiaojing Yuan, Ruoheng Gu, Nan Wang, Huihui Ren, Rui Song, Zhuo Wan, Jianyong Huang, Kaikai Yi, Chunyang Xiong, Zuoying Yuan, Yuming Zhao","doi":"10.1021/acsnano.5c03297","DOIUrl":"https://doi.org/10.1021/acsnano.5c03297","url":null,"abstract":"Biomaterials functionalized with small extracellular vesicles (sEVs) hold great regenerative potential, and their therapeutic efficacy hinges on the delivery kinetics of the sEVs. Achieving rapid and stable loading, along with precisely controlled release of sEVs, necessitates affinity modifications of biomaterials. Here, we provide a quantitative description of the interaction between sEVs and various affinity molecules (i.e., polydopamine (PDA), tannic acid (TA), heparin, polyethylenimine (PEI), and calcium phosphate (CaP)) through molecular dynamics simulation. The interaction strengths followed the order of PDA < heparin < TA < CaP < PEI. To tailor the delivery kinetics of stem cells from human exfoliated deciduous teeth (SHED)-derived sEVs with concentration-dependent bioactivities, we employed two representative affinity molecules, namely PDA and CaP, to modify PLGA porous microscaffolds (PLGA MS), resulting in PDA-modified PLGA MS (PDA@MS) and biomineralized PDA-modified PLGA MS (B/PDA@MS). The B/PDA@MS exhibited the highest loading efficiency (>20 μg/mg microscaffolds) and optimized the release profile of sEVs over 21 days. Upon injection into a 5 mm defect in the rat cranial bone, sEV-loaded B/PDA@MS demonstrated the highest level of bone regeneration, with the new bone volume fraction (BV/TV) and bone mineral density (BMD) reaching 64.0% and 604.5 mg/cm3 within 8 weeks, respectively. This work not only presents a biomineralized microscaffold with sustained sEVs release and high osteogenic potential but also offers guidance on the further design and translation of sEV-functionalized biomaterials with broader applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"49 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-Dimensional Weyl Material-Based Negative Quantum Capacitance Effect for a Steep-Slope Hysteresis-Free Switching Device 基于二维Weyl材料的陡坡无迟滞开关器件负量子电容效应

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-04-30 DOI: 10.1021/acsnano.5c00221

Xiangyu Zeng, Yang Zhang, Jiaqi Peng, Xiaoxi Li, Cizhe Fang, Yan Liu, Hao Yue, Genquan Han

{"title":"Two-Dimensional Weyl Material-Based Negative Quantum Capacitance Effect for a Steep-Slope Hysteresis-Free Switching Device","authors":"Xiangyu Zeng, Yang Zhang, Jiaqi Peng, Xiaoxi Li, Cizhe Fang, Yan Liu, Hao Yue, Genquan Han","doi":"10.1021/acsnano.5c00221","DOIUrl":"https://doi.org/10.1021/acsnano.5c00221","url":null,"abstract":"The emergence of Weyl physics and associated materials offers promising pathways to circumvent the fundamental limitation imposed by Boltzmann tyranny, a thermionic constraint governing the subthreshold slope that currently prevents further reduction of operating voltages and overall power dissipation in field-effect transistors (FETs) and related devices. In this work, an ultrathin Weyl material, WTe2, is utilized as a floating gate to achieve steep subthreshold (SS) hysteresis-free field-effect transistors based on the negative quantum capacitance (NQC) effect induced by the Weyl nodes. This device exhibits excellent performance in electrical characteristics, with a minimum SS of 20.3 mV/dec and an ultrasmall hysteresis of ∼2.6 mV. In addition, the optimal area ratio between WTe2 and the channel (MoS2) is found to be 1:1, and in this circumstance, a capacitance peak can be observed in the capacitance–voltage curve, suggesting the existence of the NQC effect. This effect is proposed to originate from the enhancement of the electron correlation effect as the Fermi level of WTe2 is tuned to approach the Weyl nodes, which presents a low carrier density of state. This work benefits the design of high integration density, energy-saving devices and provides a possible method of optimizing traditional devices by introducing Weyl physics.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"64 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0