ACS Nano最新文献

{"title":"Microelectrodes for Battery Materials","authors":"Yiyang Li, Min-Ho Kim, Zhangdi Xie, Jinhong Min, Yuzhang Li","doi":"10.1021/acsnano.4c12573","DOIUrl":"https://doi.org/10.1021/acsnano.4c12573","url":null,"abstract":"The ability to measure current and voltage is core to both fundamental study and engineering of electrochemical systems, including batteries for energy storage. Electrochemical measurements have traditionally been conducted on macroscopic electrodes on the order of 1 cm or larger. In this Perspective, we review recent developments in using microscopic electrodes (<100 μm) for the study of battery materials. Microelectrodes allow us to explore spatiotemporal regimes that are not accessible with macroscopic electrodes. Temporally, microelectrodes can generate ultrahigh current densities, enabling the distinction between solid electrolyte interphase (SEI) kinetics and metal deposition kinetics. Spatially, they confine electrochemistry to single particles, allowing us to study their intrinsic properties. We outline future opportunities for the use of microelectrodes for future studies of battery systems. We propose their use for analyzing the electrochemistry of other reactive metals and exploring the potential of combining them with in situ imaging techniques.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"93 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology Papers with an Agricultural Focus Are Too Frequently Published with a Superficial Understanding of Basic Plant and Soil Science","authors":"Søren Husted, Ismail Cakmak, Jan Kofod Schjoerring, Hans Lambers, Peter M. Kopittke, Michael J. McLaughlin","doi":"10.1021/acsnano.4c07684","DOIUrl":"https://doi.org/10.1021/acsnano.4c07684","url":null,"abstract":"This article references 17 other publications. This article has not yet been cited by other publications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"8 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electron-Beam-Induced Negative Differential Transconductance Homojunction Device Based on van der Waals Materials for Functionally Complete Ternary Computing","authors":"Maksim Andreev, Juncheol Kang, Taeran Lee, Jae-Woong Choi, Je-Jun Lee, Hyongsuk Choo, Sehee Lee, Jin-Hong Park","doi":"10.1021/acsnano.4c11169","DOIUrl":"https://doi.org/10.1021/acsnano.4c11169","url":null,"abstract":"Negative differential transconductance (NDT) devices have emerged as promising candidates for multivalued logic computing, and particularly for ternary logic systems. To enable computation of any ternary operation, it is essential to have a functionally complete set of ternary logic gates, which remains unrealized with current NDT technologies, posing a critical limitation for higher-level circuit design. Additionally, NDT devices typically rely on heterojunctions, complicating fabrication and impacting reliability due to the introduction of additional materials and interfaces. Here, we utilize an electron beam to develop tungsten diselenide (WSe₂) homojunction NDT devices with W-shaped current–voltage (<i>I</i>–<i>V</i>) characteristics. We demonstrate that electron beam enables the manipulation of Se atoms in WSe₂, facilitating controllable and spatially precise tailoring of the WSe₂ work function. The electron-beam treatment applied to a part of the WSe₂ channel induces a lateral homojunction and ultimately results in the W-shaped <i>I</i>–<i>V</i> curves, which enable both one-input and two-input ternary logic gates. We propose and implement a balanced circuit design for two-input ternary NAND, AND, NOR, and OR gates, featuring a low device count, full-swing operation, and minimized output signal variations. Together with three types of ternary inverters also designed in this work, they form a functionally complete set of ternary logic gates─a prerequisite for practical ternary computing. This work addresses a critical gap in the development of NDT-based ternary computing by ensuring functional completeness and highlights the versatility of electron-beam treatment as an engineering tool for tailoring the properties of two-dimensional van der Waals materials.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"78 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1+ Macrophages for Infectious Bone Defect Regeneration","authors":"Hao Wu, Changcheng Chen, Jiangfeng Li, Dongmei Yu, Xun Wu, Hai Huang, Zhen Tang, Qi Wu, Shichao Yan, Ning Wang, Mo Wang, Feilong Wei, Yunlong Yu, Duan Wang, Mengting Shi, Xusong Yue, Pengfei Cao, Zenghui Zheng, Xiaokang Li, Baolin Guo, Lei Shi, Zheng Guo","doi":"10.1021/acsnano.4c13562","DOIUrl":"https://doi.org/10.1021/acsnano.4c13562","url":null,"abstract":"Infectious bone defects pose significant clinical challenges due to persistent infection and impaired bone healing. Icam1⁺ macrophages were identified as crucial and previously unrecognized regulators in the repair of bone defects, where impaired oxidative phosphorylation within this macrophage subset represents a significant barrier to effective bone regeneration. To address this challenge, dual-responsive iron-doped barium titanate (BFTO) nanoparticles were synthesized with magnetic and ultrasonic properties. These nanoparticles were further loaded with the anti-inflammatory agent curcumin and coated with engineered mesenchymal stem cell membranes (EMM) modified with γ3 peptide, creating BFTO-Cur@EMM nanoparticles specifically designed to target Icam1⁺ macrophages. These nanoparticles were shown to disrupt bacterial biofilms under alternating magnetic fields (AMF) and to activate oxidative phosphorylation and osteogenic immune responses in Icam1+ macrophages via low-intensity pulsed ultrasound (LIPUS). Transcriptomic sequencing and validation experiments demonstrated that this approach activates oxidative phosphorylation (OXPHOS) by stimulating the JAK2-STAT3 pathway and inhibiting the MAPK-JNK pathway, thereby promoting the polarization of Icam1+ macrophages toward a pro-reparative phenotype and enhancing the secretion of pro-angiogenic and osteogenic cytokines. These nanoparticles were subsequently integrated into quaternized chitosan (QCS) and tricalcium phosphate (TCP) to create a bioink for three-dimensional (3D) printing anti-infection QT/BFTO-Cur@EMM bone repair scaffolds. In vivo studies indicated that these scaffolds significantly improved the healing of infectious bone defects without causing thermal damage to surrounding tissues. This work highlights the potential of this material and the targeting of Icam1⁺ macrophages as an effective strategy for simultaneously controlling infection and promoting bone regeneration.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"24 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemically Tailored Host Design with Gradient Seeds for Dendrite-Free Li Metal Batteries","authors":"Hyeonmin Jo, Jun-Won Lee, Eunji Kwon, Seungho Yu, Byung Gon Kim, Seongsoo Park, Janghyuk Moon, Min Jae Ko, Hee-Dae Lim","doi":"10.1021/acsnano.4c15556","DOIUrl":"https://doi.org/10.1021/acsnano.4c15556","url":null,"abstract":"Dendritic challenges in Li metal batteries are commonly resolved using porous three-dimensional (3D) current collectors, which have a significant issue in that Li is deposited from the top (top growth) of the structure rather than from the bottom (bottom growth), failing to effectively suppress dendrite growth and volumetric expansion. We propose the structure incorporating a gradient lithiophilic seed within a 3D framework by pulse electroplating Mg, specifically targeting the near bottom to promote bottom growth and achieve dense Li deposition. This method achieves precise control over the catalytic seed size and distribution. Optimal conditions for maximizing the catalytic effect are identified. The resulting Mg-gradient porous-Cu structure exhibits superior Li-plating behavior with bottom growth, significantly reducing dendrite formation and improving cycle life. The mechanistic origin of bottom-guided Li growth is supported by DFT and 3D simulation results. This method presents a significant step forward in developing high-performance Li–metal batteries.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"50 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cascade-Activatable Nanoprodrug System Augments Sonochemotherapy of Bladder Cancer","authors":"Da-Yong Hou, Qing You, Peng Zhang, Xiang-Peng Li, Jiong-Cheng Wu, Yueze Wang, Hui-Hui You, Mei-Yu Lv, Gege Wu, Xiao Liu, Pengyu Guo, Dong-Bing Cheng, Xiaoyuan Chen, Wanhai Xu","doi":"10.1021/acsnano.4c12967","DOIUrl":"https://doi.org/10.1021/acsnano.4c12967","url":null,"abstract":"Sonochemotherapy (SCT) has emerged as a powerful modality for cancer treatment by triggering excessive production of reactive oxygen species (ROS) and controlled release of chemotherapeutic agents under ultrasound. However, achieving spatiotemporally controlled release of chemotherapeutic agents during ROS generation is still an enormous challenge. In this work, we developed a cascade-activated nanoprodrug (<b>CAN</b>) system that utilizes a reversible covalent Schiff base mixed with a hypoxia-activatable camptothecin (CPT) prodrug. Briefly, the designed fluorinated <b>CAN</b> system is self-assembled into nanoparticles under aqueous conditions, which could penetrate deep tumors to offer sufficient oxygen for ultrasound-triggered ROS production. Consequently, the nanoparticles substantially exacerbated the hypoxia of the tumor microenvironment (TME) by elevating oxygen consumption. The aggravated hypoxia in turn served as a positive amplifier to boost the tumor-specific CPT release of Azo-CPT prodrug, which made up for the insufficient treatment efficacy of sonodynamic therapy (SDT). On this basis, we observed a substantial reduction, approximately 3.5-fold, in the half-maximal inhibitory concentration (IC₅₀) of the <b>CAN</b> system compared to that of free CPT in bladder cancer cell lines (T24). Furthermore, the <b>CAN</b> system demonstrated potent antitumor efficacy with reduced side effects, resulting in regression and eradication of T24 tumors in various mouse models. In summary, the <b>CAN</b> system can be easily extended by incorporating different chemotherapeutic agents, showing great potential to revolutionize the clinical management paradigm of bladder cancer.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"30 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology Papers with an Agricultural Focus Are Too Frequently Published with a Superficial Understanding of Basic Plant and Soil Science","authors":"Søren Husted*,&nbsp;Ismail Cakmak,&nbsp;Jan Kofod Schjoerring,&nbsp;Hans Lambers,&nbsp;Peter M. Kopittke and Michael J. McLaughlin,&nbsp;","doi":"10.1021/acsnano.4c0768410.1021/acsnano.4c07684","DOIUrl":"https://doi.org/10.1021/acsnano.4c07684https://doi.org/10.1021/acsnano.4c07684","url":null,"abstract":"","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"18 50","pages":"33767–33770 33767–33770"},"PeriodicalIF":15.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generality Rules and Synergistic Effect of Mitigating the Jahn-Teller Effect by Multisites Compositionally Complex Doping.","authors":"Shuyu Zhou, Junhong Liao, Chenglong Yu, Pengpeng Dai, Tong Gao, Tingzheng Hou, Guozhong Cao, Shixi Zhao","doi":"10.1021/acsnano.4c12022","DOIUrl":"https://doi.org/10.1021/acsnano.4c12022","url":null,"abstract":"<p><p>The Jahn-Teller (JT) deformation triggers severe structural distortion and large capacity fading in the cathode materials of alkali-ion batteries. Although conventional doping containing over 20 dopant species has been demonstrated to suppress the JT effect, how the short-range and cooperative JT effect are regulated remains an open question. Recently, the new compositionally complex (high entropy) doping has been validated in various oxide cathodes and achieved \"zero strain\", but the reported \"synergistic effect\" is largely factual reporting with a limited fundamental understanding of the link between multicomponents and the JT effect. By comparing a group of spinel LiMn₂O₄ (LMO) cathodes with tridoping sites containing one, three, or five dopants' species, the present work shows that MnO₆ octahedral distortion systematically decreases, whereas capacity retention and structure stability systematically increase as the number of dopants' species increases. We propose the generality rules that Mn-site doping breaks the linear continuous short-range JT distortion while 16c-sites doping disturbs the d_<i>z</i>²-orbital collinear ordering and mitigates the cooperative JT effect. Moreover, our complex doping strategy further buffers and rotates the JT strain, resulting in isotropic moderate volume distortion. Based on this synergic effect, both the short-range and cooperative JT effect are significantly suppressed in our synthesized multisites multicomponent doped LMO.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achieving Robust α-Alumina Nanofibers by Ligand Confinement Coupled with Local Disorder Tuning","authors":"Jin Dai, Fan Wu, Hualei Liu, Siyu Qiang, Liqian Huang, Renchao Che, Jianyong Yu, Yi-Tao Liu, Bin Ding","doi":"10.1021/acsnano.4c12568","DOIUrl":"https://doi.org/10.1021/acsnano.4c12568","url":null,"abstract":"As high-performance thermal protection and structure enhancement materials, oxide ceramic fibers have become indispensable in numerous areas, ranging from deep-sea exploration to supersonic aircraft. However, under extreme energy input, abnormal grain growth and inevitable vermiculate structure would break the fiber integrity, causing catastrophic structure failure. Nowadays, the design of nanoceramics brings potential answers for strengthening of mechanical properties, but with the diameter downsized to the nanoscale, the increasing structural susceptibility of ceramic fiber to phase transformation and grain growth becomes a huge barrier. Here, we propose a strong carboxylic ligand confinement strategy by the combination of formic and acetic acids to control the inorganic colloid growth for fabricating robust α-alumina nanofibers. The rapid hydrolysis and coordination of the carboxylate groups with aluminum together with subsequent concentration synergistically promote the formation of small and compact precursor colloids, laying a solid foundation for suppressing abnormal grain growth and achieving refined alumina grain structure. The local disorder induced by silica and boron oxide surrounding α-alumina grains imparts excellent mechanical properties and flexibility with no fractures observed even after 500 buckling cycles and a wide range of temperatures from −196 to 1100 °C, providing an enlightening paradigm for ceramic fiber strengthening.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"38 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Polypeptosome Spray To Heal Antibiotic-Resistant Bacteria-Infected Wound by Photocatalysis-Induced Metabolism-Interference","authors":"Tao Wang, Runxin Teng, Mengjie Wu, Zhenghong Ge, Yaping Liu, Biao Yang, Chang Li, Zhen Fan, Jianzhong Du","doi":"10.1021/acsnano.4c13965","DOIUrl":"https://doi.org/10.1021/acsnano.4c13965","url":null,"abstract":"With the booming antimicrobial drug resistance worldwide, traditional antibacterial agents (e.g., antibiotics) are usually powerless against superbug. Targeting antibacterial pathways different from traditional antibiotics could be an effective approach to treating wounds with a resistant bacterial infection. In this work, an antibacterial polymersome was developed to physically induce bacterial membrane damage and interfere with bacterial metabolism. First, we synthesized an antibacterial poly(ε-caprolactone)-<i>block</i>-poly(glutamic acid)-<i>block</i>-poly(Lys-<i>stat</i>-Phe) copolymer, which was then self-assembled into polypeptosome with the amplification of surface positive charges to disrupt bacterial membranes. In addition, the polypeptosome was further decorated with photocatalytic bismuth sulfide (Bi₂S₃) nanoparticles as a photocatalyst to interfere with reduced nicotinamide adenine dinucleotide (NADH) conversion. Specifically, near-infrared light generated free electrons from Bi₂S₃ nanoparticles could effectively interfere with NADH homeostasis to induce antibiotic-resistant bacteria death, as verified by transcriptome sequence analysis. Moreover, effective healing of antibiotic-resistant bacteria-infected wounds of mice was achieved with a spray of polypeptosome dispersion. Overall, we provided a fresh strategy to integrate bacterial membrane damage and metabolism interference functions within antibacterial polymersomes for healing antibiotic-resistant bacteria-infected wound.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"11 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}