ACS Nano最新文献_第7页

ReversibleFerroelastic Strain Engineering EnablesStabilization of a Hidden Ga2O3 Polymorph 可逆铁弹性应变工程使隐藏的Ga2O3多晶稳定

IF 17.1 1区材料科学

ACS Nano Pub Date : 2026-10-17 DOI: 10.1021/acsnano.6c12416

Zijun Qi,Zhanpeng Sun,Rui Li,Qijun Wang,Jingyuan Ni,Sheng Liu,Wei Shen,Gai Wu

{"title":"Reversible\u0000Ferroelastic Strain Engineering Enables\u0000Stabilization of a Hidden Ga2O3 Polymorph","authors":"Zijun Qi,Zhanpeng Sun,Rui Li,Qijun Wang,Jingyuan Ni,Sheng Liu,Wei Shen,Gai Wu","doi":"10.1021/acsnano.6c12416","DOIUrl":"https://doi.org/10.1021/acsnano.6c12416","url":null,"abstract":"Abstract Understanding the formation, transformation, and stabilization of metastable polymorphs in functional compounds is a central challenge in materials science and has a profound impact on phase engineering and property control. Ga2O3 is an ultrawide bandgap semiconductor whose rich polymorphism underpins diverse electronic and optoelectronic functionalities, motivating continued exploration of its metastable phases. Among the known Ga2O3 polymorphs, the P1̅-phase has been predicted to have the closest energy to the thermodynamically stable β-phase; however, its existence has not been definitively identified experimentally, and feasible preparation routes remain unclear up to now. Here, combining large-scale molecular dynamics simulations with a high-accuracy machine learning potential, we reveal a reversible strain-induced ferroelastic β–P1̅ phase transition in Ga2O3 and further investigate the origin of instability of P1̅-Ga2O3. Our work not only explains the absence of experimental observations of P1̅-Ga2O3 from the perspectives of mechanical stability and crystallization kinetics but also extends the application of strain engineering in phase transitions of wide-bandgap semiconductor single-crystal materials.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"80 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DynamicTi–Cl Bonding Enables Corrosion-Resistantand Robust Seawater Electrolysis 动态ti - cl键合，可实现耐腐蚀和坚固的海水电解

IF 17.1 1区材料科学

ACS Nano Pub Date : 2026-10-16 DOI: 10.1021/acsnano.6c13059

Yue Xu,Shuaidong Li,Yuxin Hao,Wenzong Song,Jingzi Zhang,Kaikai Li,Yan Huang,Samuel Jeong,Zeyun Cai,Kailong Hu

{"title":"Dynamic\u0000Ti–Cl Bonding Enables Corrosion-Resistant\u0000and Robust Seawater Electrolysis","authors":"Yue Xu,Shuaidong Li,Yuxin Hao,Wenzong Song,Jingzi Zhang,Kaikai Li,Yan Huang,Samuel Jeong,Zeyun Cai,Kailong Hu","doi":"10.1021/acsnano.6c13059","DOIUrl":"https://doi.org/10.1021/acsnano.6c13059","url":null,"abstract":"Abstract Seawater electrolysis is essential for sustainable green hydrogen production but remains hindered by chloride ions (Cl–)-induced corrosion of electrode catalysts. Herein, we report an “adsorption-guided protection” strategy to achieve the trade-off between corrosion resistance and oxygen evolution reaction (OER) activity for NiFe layered double hydroxide (NiFe-LDH). Unlike conventional strategies that aim solely to repel Cl–, this strategy incorporates Ti dopants as preferential Cl–-trapping centers. The Cl– dynamically adsorbed on Ti sites shields the OER-active Ni/Fe centers from corrosive attack and concurrently creates a localized electrostatic repulsion that inhibits further Cl– accumulation on the catalyst surface. NiFeTi-LDH exhibits high OER performance in alkaline seawater, achieving ampere-level current density with outstanding stability exceeding 3000 h. In situ spectroscopic analysis combined with theoretical calculations reveals that the Ti–Cl bonding not only lowers the energy barrier of the rate-determining step for OER intermediates but also induces an electrostatic repulsion effect that further excludes additional Cl– from approaching the active surface. This study offers insights into the reasonable design of high-performance and corrosion-resistant non-noble-metal catalysts for practical seawater electrolysis.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"13 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Static Architectures:Responsive TetrahedralFramework Nucleic Acids for Precise Theranostics 超越静态架构：用于精确治疗的响应性四面体框架核酸

IF 17.1 1区材料科学

ACS Nano Pub Date : 2026-10-16 DOI: 10.1021/acsnano.6c09712

Yang Gao,Geru Zhang,Xinyu Wu,Jiayi Deng,Tianqi Wang,Xiaoxiao Cai,Yao He,Xingyu Chen,Yunfeng Lin

{"title":"Beyond Static Architectures:\u0000Responsive Tetrahedral\u0000Framework Nucleic Acids for Precise Theranostics","authors":"Yang Gao,Geru Zhang,Xinyu Wu,Jiayi Deng,Tianqi Wang,Xiaoxiao Cai,Yao He,Xingyu Chen,Yunfeng Lin","doi":"10.1021/acsnano.6c09712","DOIUrl":"https://doi.org/10.1021/acsnano.6c09712","url":null,"abstract":"Abstract Precise theranostics requires spatiotemporal control and high specificity to adapt to complex physiological microenvironments. Tetrahedral framework nucleic acids (tFNA), classic 3D DNA nanostructures, offer distinct advantages such as atomic-level structural precision, intrinsic programmability, and excellent biocompatibility. While traditional static tFNA lack dynamic responsiveness to external stimuli─severely limiting their clinical translation potential─the emergence of dynamically responsive tFNA has garnered increasing attention. These smart systems offer substantial advantages, including stimulus-triggered structural reconfiguration, targeted payload release, and real-time signal transduction. Despite rapid design innovations, a systematic summary of dynamic tFNA strategies remains lacking. Accordingly, we synthesize the design principles of responsive tFNA by categorizing their mechanisms into conformational rearrangement, chemical bond cleavage, and toehold-mediated strand displacement logic. We highlight their applications in precision diagnosis, smart therapeutics, and theranostics integration and discuss critical challenges in biological stability, scalable manufacturing, and biosecurity. By mapping current advancements and unresolved hurdles, this work provides a comprehensive reference for the rational design of responsive DNA nanodevices and discusses the challenges associated with the clinical translation of dynamic tFNA.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"412 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-DimensionalNanostructured Molecular Architecturesfor Advanced CO2 Electroreduction 先进CO2电还原的低维纳米结构分子结构

IF 17.1 1区材料科学

ACS Nano Pub Date : 2026-10-16 DOI: 10.1021/acsnano.6c17097

Yinger Xin,Yun Song,Weihua Guo,Qiang Zhang,Mingming He,Zihao Li,Ruixuan Wang,Rui Xue,Jia Pan,Huiying Deng,Ruquan Ye

{"title":"Low-Dimensional\u0000Nanostructured Molecular Architectures\u0000for Advanced CO2 Electroreduction","authors":"Yinger Xin,Yun Song,Weihua Guo,Qiang Zhang,Mingming He,Zihao Li,Ruixuan Wang,Rui Xue,Jia Pan,Huiying Deng,Ruquan Ye","doi":"10.1021/acsnano.6c17097","DOIUrl":"https://doi.org/10.1021/acsnano.6c17097","url":null,"abstract":"Abstract Molecular catalysts have been found to be selective for the CO2 reduction reaction (CO2RR), with Faradaic efficiencies approaching 100% for two-electron products such as CO and formic acid. However, translating the intrinsic activity of well-defined molecular active sites into practical high-current-density electrolysis remains challenging due to molecular aggregation, poor electronic coupling with electrodes, and limited stability. In addition, multielectron molecular CO2RR is hampered by complex reaction pathways and insufficient adsorption of intermediates. This perspective discusses how nanostructured molecular architectures, from controlled aggregation and support interactions to reticular frameworks, fundamentally alter catalytic performance beyond what is achievable through conventional coordination chemistry alone. We highlight recent advances demonstrating that molecular dispersion, curvature-induced strain, nanoconfinement, and layered confinement can redirect reaction pathways, enabling multielectron reduction products such as methanol and ethanol. We further discuss emerging opportunities in computation-accelerated molecular discovery, strategies to address high overpotentials, and the integration of CO2 capture with electrochemical conversion. By engineering the microenvironment surrounding molecular active sites, we argue that the next generation of molecular electrocatalysts can achieve the activity, selectivity, and stability required for practical deployment.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"12 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold NanourchinsPotentiate Intravesical Chemotherapyby Accelerating Drug Internalization within a Short Instillation Window 纳米金钠通过在短时间内加速药物内化来促进膀胱化疗

IF 17.1 1区材料科学

ACS Nano Pub Date : 2026-10-16 DOI: 10.1021/acsnano.6c10659

Peiyu Yu,Menghua Gao,Xuefei Feng,Haowei Rong,Fei Feng,Lei Zhang,Yan Bao,Menghua Xiong,Yaofeng Zhou,Jianjun Cheng

{"title":"Gold Nanourchins\u0000Potentiate Intravesical Chemotherapy\u0000by Accelerating Drug Internalization within a Short Instillation Window","authors":"Peiyu Yu,Menghua Gao,Xuefei Feng,Haowei Rong,Fei Feng,Lei Zhang,Yan Bao,Menghua Xiong,Yaofeng Zhou,Jianjun Cheng","doi":"10.1021/acsnano.6c10659","DOIUrl":"https://doi.org/10.1021/acsnano.6c10659","url":null,"abstract":"Abstract Intravesical chemotherapy is a standard adjuvant treatment for nonmuscle-invasive bladder cancer after transurethral resection, but its efficacy is limited by drug exposure resulting from urinary dilution and physiological voiding. Most current delivery strategies aim to prolong the intravesical residence through mucoadhesion, depot formation, or sustained release. Although these approaches increase local drug availability, they do not directly address insufficient intracellular drug accumulation during the short instillation window. Here, we report a poly-l-glutamic acid-modified gold nanourchin platform, PGU3@DOX, designed to enhance intravesical chemotherapy by accelerating drug internalization by bladder cancer cells. By optimizing the nanoparticle morphology, we identified long-spiked gold nanourchins as the most effective architecture for rapid cellular uptake. The PLG coating enabled doxorubicin loading and supported pH-facilitated DOX release, while the internalized nanourchins induced lysosomal swelling and lysosomal membrane permeabilization in bladder cancer cells. Under a 1 h pulse exposure that mimics the short intravesical dwell-time window, PGU3@DOX showed greater cytotoxicity against bladder cancer cells after extracellular drug removal while showing lower toxicity toward normal urothelial cells. Furthermore, PGU3@DOX achieved a broader distribution and stronger damage in tumor spheroids than free DOX. In an orthotopic bladder cancer model, a single short-duration intravesical administration of PGU3@DOX significantly suppressed tumor progression without detectable acute hematological, hepatic, renal, or cardiac toxicity under the tested conditions. These findings support rapid cellular internalization as a complementary strategy to improve intravesical chemotherapy and provide a morphology-guided nanocarrier platform for enhancing drug delivery within short therapeutic exposure windows.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"1 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoconfined ProteinScaffold as a Generalizable PlatformEmpowers Synergistic Enzyme–Nanozyme Catalysis for CascadeBiotransformation 纳米蛋白支架作为一个可推广的平台，为级联生物转化提供协同酶-纳米酶催化

IF 17.1 1区材料科学

ACS Nano Pub Date : 2026-10-15 DOI: 10.1021/acsnano.6c09440

Zixia Zhang,Ruofei Zhang,Xuejiao J. Gao,Yuanjie Ma,Hanqing Zhao,Huan Li,Chen Zhang,Nini Zhang,Zhenxi Guo,Xiyun Yan,Feng Cheng,Kelong Fan

{"title":"Nanoconfined Protein\u0000Scaffold as a Generalizable Platform\u0000Empowers Synergistic Enzyme–Nanozyme Catalysis for Cascade\u0000Biotransformation","authors":"Zixia Zhang,Ruofei Zhang,Xuejiao J. Gao,Yuanjie Ma,Hanqing Zhao,Huan Li,Chen Zhang,Nini Zhang,Zhenxi Guo,Xiyun Yan,Feng Cheng,Kelong Fan","doi":"10.1021/acsnano.6c09440","DOIUrl":"https://doi.org/10.1021/acsnano.6c09440","url":null,"abstract":"Abstract Enzymatic and chemoenzymatic cascades hold immense potential for industrial applications but are hindered by inherent instability, low atom economy, inefficient intermediate transfer, and complex enzyme immobilization processes. Here, we repurpose encapsulin, which naturally loads cargo, as a programmable nanoreactor to assemble an enzyme–nanozyme cascade inside the nanoconfined cavity (EcENN). d-Amino acid oxidase (DAAO) was fused with a targeting peptide for selective encapsulation during self-assembly, while palladium (Pd) nanozymes were biomineralized inside the same compartment for in situ toxic byproduct elimination. Molecular dynamics simulations revealed Pd nanozyme enrichment directly on the enzyme surface, minimizing intermediate diffusion losses. Consequently, EcENN showed a 7-fold increase in pyruvic acid titers in laboratory settings and presented up to a 93.1% conversion rate (versus 49.7% for free DAAO) in pilot-scale assays. Overall, this work provides a generalizable precision nanoconfinement strategy for constructing robust biocatalytic cascades, with potential in the synthesis of α-keto acid and pharmaceutical intermediates.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"52 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Shot PolarizationImaging of Vectorial MetasurfacesUsing Cross-Grating Wavefront Microscopy 交叉光栅波前显微镜的矢量超表面单次偏振成像

IF 17.1 1区材料科学

ACS Nano Pub Date : 2026-10-15 DOI: 10.1021/acsnano.6c06635

Julien Flamant,Baptiste Marthy,Khosro Zangeneh Kamali,Nathan Ullberg,Guillaume Demesy,Patrick Ferrand,Mikael Käll,Guillaume Baffou

{"title":"Single-Shot Polarization\u0000Imaging of Vectorial Metasurfaces\u0000Using Cross-Grating Wavefront Microscopy","authors":"Julien Flamant,Baptiste Marthy,Khosro Zangeneh Kamali,Nathan Ullberg,Guillaume Demesy,Patrick Ferrand,Mikael Käll,Guillaume Baffou","doi":"10.1021/acsnano.6c06635","DOIUrl":"https://doi.org/10.1021/acsnano.6c06635","url":null,"abstract":"Abstract Nanophotonics and optical microscopy are now tightly intertwined in modern research, as high-resolution optical characterization is essential for studying nanomaterials, such as dielectric and plasmonic nanoparticles, metasurfaces, and 2D materials. Yet, existing microscopy techniques are often complex to implement or limited to measuring light intensity, overlooking spectral, phase, and polarization features. Here, we report an optical microscopy approach capable of retrieving the full complex vectorial electromagnetic field at the image plane (that is, intensity, phase, and polarization of light) in a single acquisition. The method combines a polarization-sensitive camera with a two-dimensional diffraction grating (cross-grating) placed in close proximity to the image sensor. Beyond light beam characterization, we show how this configuration enables sample characterization in two image acquisitions, through Jones matrix imaging, from which we derive the complex transmittance tensor of metasurfaces. This accessible technique, easy to implement in any preexisting microscope, offers a comprehensive metrology platform for advanced studies of metasurfaces and 2D materials, in line with the growing interest in polarization-resolved nanophotonics.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"22 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the StructuralOrigin of Low-Frequency Noisein Organic Photodetectors 揭示有机光电探测器低频噪声的结构来源

IF 17.1 1区材料科学

ACS Nano Pub Date : 2026-10-15 DOI: 10.1021/acsnano.6c15105

Gyeong Min Lee,Ohhyun Kwon,Hyungju Ahn,Myung-Seok Lee,Jung-Hyun Lee,Han Jung Park,Jae Won Shim

{"title":"Unveiling the Structural\u0000Origin of Low-Frequency Noise\u0000in Organic Photodetectors","authors":"Gyeong Min Lee,Ohhyun Kwon,Hyungju Ahn,Myung-Seok Lee,Jung-Hyun Lee,Han Jung Park,Jae Won Shim","doi":"10.1021/acsnano.6c15105","DOIUrl":"https://doi.org/10.1021/acsnano.6c15105","url":null,"abstract":"Abstract Active-layer morphology critically shapes the low-frequency noise characteristics of organic photodetectors (OPDs), yet the mechanistic link between crystallization pathway and power spectral density (PSD) remains underexplored. This study demonstrates that solvent evaporation kinetics governs a crystallization sequence that determines low-frequency noise in PM6:Y6 ternary OPDs. Differential scanning calorimetry and surface-energy measurements show that L8-BO has an approximately 41% lower nucleation barrier than Y6, a thermodynamic hierarchy that places L8-BO as the preferentially nucleating component and directs fast-drying chloroform (CF) processing toward a seeded alloy formation route. This nucleation-seeded pathway produces a structurally uniform alloy-like acceptor phase with suppressed energetic disorder (17.9 meV) and low trap density (2.54 × 1012 cm–3). In contrast, slow-drying chlorobenzene (CB) promotes competitive dual-phase crystallization, increases trap density to approximately 4.98 × 1013 cm–3, and drives dark-current activation energy well below Eg/2, indicating shunt-like interfacial leakage. Lorentzian generation-recombination (G-R) noise analysis shows that the G-R roll-off frequency increases monotonically with reverse bias in CF-processed OPDs, consistent with Poole–Frenkel-enhanced Shockley-Read-Hall (SRH) emission from well-localized midgap traps. This trap-kinetics-resolved PSD analysis establishes crystallization pathway engineering as a physically grounded strategy for noise-aware OPD design.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"39 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the RenalBio–Nano Interface: PhysicochemicalRules for Crossing Barriers and Cellular Transport 导航RenalBio-Nano界面：跨越障碍和细胞运输的物理化学规则

IF 17.1 1区材料科学

ACS Nano Pub Date : 2026-10-15 DOI: 10.1021/acsnano.6c14253

Chuyue Zhang,Keyu Ren,Yihao Zhong,Ping Fu

{"title":"Navigating the Renal\u0000Bio–Nano Interface: Physicochemical\u0000Rules for Crossing Barriers and Cellular Transport","authors":"Chuyue Zhang,Keyu Ren,Yihao Zhong,Ping Fu","doi":"10.1021/acsnano.6c14253","DOIUrl":"https://doi.org/10.1021/acsnano.6c14253","url":null,"abstract":"Abstract As a highly perfused and selective filtration organ, the kidney features complex, highly differentiated bio–nano interfaces. Conventional research focusing on organ homing largely prioritizes total renal drug exposure, yet therapeutic efficacy depends on crossing specific interfaces to meet pathological demands─aspects that remain poorly delineated. This review deconstructs the kidney into five serial bio–nano interfaces and defines the rules that govern nanoparticle fate at each of them. We then show how a kidney disease microenvironment rewrites these transport rules via interface reprogramming. Based on this, it outlines the corresponding delivery strategies tailored to three primary pathological modules. In glomerular diseases, spatial redistribution caused by barrier disruption is exploited for targeted entrapment. In tubular injury, the uptake decline from receptor downregulation is bypassed via basolateral pathways or uptake-independent extracellular interventions. In interstitial–vascular diseases, the transport barrier characterized by enhanced extravasation but restricted deep diffusion, resulting from microvascular leakage and fibrotic resistance, is overcome by leveraging microenvironmental features to build local drug reservoirs. Finally, considering translational hurdles and long-term retention risks, future material design must advance toward dynamic interface responsiveness, precise subcellular compartmentalization, and safe clearance. This framework aims to provide a physicochemical rationale for targeting distinct renal subregions and designing nanomedicines tailored to specific disease stages.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"69 2 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

14C-EnabledQuantitative Fate Mappingof Orally Administered Polystyrene Nanoplastics in Laying Hens 口服聚苯乙烯纳米塑料在蛋鸡中的定量命运定位

IF 17.1 1区材料科学

ACS Nano Pub Date : 2026-10-15 DOI: 10.1021/acsnano.6c09648

Ting Chen,Yan Chen,Xilin Wang,Yandao Chen,Nan Zheng,Luwen Wang,Zhiyang Yu,Sufen Zhang,Lei Xu,Qing X. Li,Haiyan Wang

{"title":"14C-Enabled\u0000Quantitative Fate Mapping\u0000of Orally Administered Polystyrene Nanoplastics in Laying Hens","authors":"Ting Chen,Yan Chen,Xilin Wang,Yandao Chen,Nan Zheng,Luwen Wang,Zhiyang Yu,Sufen Zhang,Lei Xu,Qing X. Li,Haiyan Wang","doi":"10.1021/acsnano.6c09648","DOIUrl":"https://doi.org/10.1021/acsnano.6c09648","url":null,"abstract":"Abstract Nanoplastics are emerging pollutants of global concern, yet their quantitative in vivo fate in terrestrial vertebrates remains poorly resolved owing to analytical limitations. Here, we constructed a quantitative whole-body fate map in laying hens orally exposed to backbone 14C-labeled polystyrene nanoplastics (PS-NPs) at 0.4 mg kg–1 day–1, a dose selected to represent an environmentally plausible upper-bound exposure scenario. The 14C-PS-NPs had an approximately 80 nm dry-state primary particle diameter, while the vacuum-dried dosing material showed micrometer-scale agglomeration upon standardized redispersion. Excreta represented the dominant compartment in the mass balance, accounting for 88.55 ± 0.54% and 90.06 ± 1.02% of the cumulative administered dose after 3- and 7-day exposures, respectively. Gastrointestinal contents constituted the largest residual nonexcreted compartment, whereas kidney, liver, and lung showed the most prominent 14C signals among internal organs. Trace brain-associated 14C was below the matrix-specific LOD at day 3 but quantifiable at day 7, and the overall egg-associated signal remained below 0.1% of the cumulative administered dose. In a complementary 21-day dietary study, laying hens were exposed to PS-NPs at 0.4 and 2 mg kg–1 day–1 to assess intestinal responses together with circulating and selected-organ readouts. The 21-day study showed intestinal histopathological changes, elevated permeability markers, and pro-inflammatory and oxidative-stress readouts, while cecal microbiota compositional shifts were most evident in the 2 mg kg–1 day–1 group. This study provides a quantitative whole-body fate map of PS-derived 14C together with an assessment of biological responses to repeated dietary PS-NP exposure in laying hens.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"11 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0