ACS Nano最新文献_第7页

Trace-Cobalt Surface Engineering of Ni-Rich Co-Free Cathodes Unlocks High-Power Density and Long-Cycle Life in Pouch-Type Li-Ion Batteries. 富镍无钴阴极的微量钴表面工程解锁袋式锂离子电池的高功率密度和长循环寿命

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-16 DOI: 10.1021/acsnano.5c12594

Haifeng Yu,Zhihua Ren,Zhihong Wang,Hui Sun,Ling Chen,Hao Jiang,Chunzhong Li

{"title":"Trace-Cobalt Surface Engineering of Ni-Rich Co-Free Cathodes Unlocks High-Power Density and Long-Cycle Life in Pouch-Type Li-Ion Batteries.","authors":"Haifeng Yu,Zhihua Ren,Zhihong Wang,Hui Sun,Ling Chen,Hao Jiang,Chunzhong Li","doi":"10.1021/acsnano.5c12594","DOIUrl":"https://doi.org/10.1021/acsnano.5c12594","url":null,"abstract":"Layered Ni-rich Co-free cathodes offer compelling advantages in energy density and cost-effectiveness, but their practical deployment is significantly hindered by structural instability and sluggish charge transfer kinetics. Herein, we report a spinel Li1-xCoO2 surface-engineered LiNi0.92Mn0.05Al0.03O2 (Co-NMA) cathode with only ∼2000 ppm Co, in which the efficient utilization of trace Co dramatically enhances both structural integrity and interfacial reaction kinetics. Comprehensive in/ex situ spectrochemical analyses reveal that surface engineering effectively suppresses parasitic interface reactions with negligible O2/CO2 emission in the first charge process. Concurrently, spinel Li1-xCoO2 facilitates faster Li+ diffusion and electron transfer, resulting in lower electrochemical polarization and higher phase-transition reversibility. Consequently, the Co-NMA delivers a high reversible capacity of 225.3 mAh g-1 at 0.1C and an initial Coulombic efficiency of 93.4%. It retains 62.1% of its capacity retention even at 10C, greatly outperforming the corresponding quaternary NMCA (54.2%) and NMA (49.1%). In pouch-type full cells, the Co-NMA sustains an extended cycle life over 650 cycles with 80% capacity retention, far surpassing NMCA (<320 cycles) and the reported NMA-based cathodes.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"1 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micro/Nanofiber-Network Assembled Aramid Paper with Excellent Mechanical and Electrical Insulating Properties. 具有优异机电绝缘性能的微/纳米纤维网络组合芳纶纸。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-16 DOI: 10.1021/acsnano.5c10576

Bin Yang,Yifan Wang,Yi Zhou,Jiale He,Ping Xu,Meiyun Zhang

{"title":"Micro/Nanofiber-Network Assembled Aramid Paper with Excellent Mechanical and Electrical Insulating Properties.","authors":"Bin Yang,Yifan Wang,Yi Zhou,Jiale He,Ping Xu,Meiyun Zhang","doi":"10.1021/acsnano.5c10576","DOIUrl":"https://doi.org/10.1021/acsnano.5c10576","url":null,"abstract":"Aramid nanofiber (ANF) paper exhibits excellent dielectric strength, positioning it as a promising candidate for an electrical insulating material. However, it suffers from extremely poor tear strength induced by the tremendous hydrogen bond and fully immobilized nodes among the ANF network that significantly restrict their capacity for energy dissipation through fiber slippage and network redistribution, causing rapid crack propagation and catastrophic tearing for ANF paper. Herein, we report a PMIA@ANF composite nanopaper with a reinforced-concrete architecture assembled by the microscope poly(m-phenylene isophthalamide) (PMIA) fiber and ANF network with optimized nodal strength and density, facilitating timely dissipation of shear stresses through fiber slippage and network redistribution, thereby retarding catastrophic tearing. The obtained PMIA@ANF composite nanopaper achieves a mechanical breakthrough with a tear strength of 1899 mN, representing a 47.5-fold enhancement over ANF paper. Surprisingly, the micro/nano synergy of PMIA@ANF network eliminates voids within the traditional PMIA network, achieving a gratifying dielectric strength of up to 82.8 kV·mm-1. The PMIA@ANF composite nanopaper significantly outperforms previously reported electrical insulation composites in both tear strength and dielectric strength, attributable to its exceptional reinforced-concrete architecture that synergistically balances structural durability and dielectric reliability. Furthermore, the PMIA@ANF composite demonstrates exceptional environmental resilience, as evidenced by its retained performance under extreme conditions spanning high temperatures (100-200 °C), cryogenic exposure (-196 °C), and corrosive chemical environments. These attributes position PMIA@ANF composite nanopaper as a promising candidate for advanced electrical insulation in next-generation insulation equipment.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"30 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Actin Polymerizing Motors to Assist Cytoskeleton-like Networks Formation in Artificial Cells. 肌动蛋白聚合马达协助人工细胞中细胞骨架样网络的形成。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-16 DOI: 10.1021/acsnano.5c12624

Miguel A Ramos Docampo,Cathrine Abild Meyer,Cecilie Ryberg,Daniel E Otzen,Christian Hirsch,Brigitte Städler

{"title":"Actin Polymerizing Motors to Assist Cytoskeleton-like Networks Formation in Artificial Cells.","authors":"Miguel A Ramos Docampo,Cathrine Abild Meyer,Cecilie Ryberg,Daniel E Otzen,Christian Hirsch,Brigitte Städler","doi":"10.1021/acsnano.5c12624","DOIUrl":"https://doi.org/10.1021/acsnano.5c12624","url":null,"abstract":"Artificial cells are man-made systems that imitate specific functions of biological cells to study or harness cellular behavior. Biological cells can respond to external forces and signals by altering their shape, undergoing deformation, and generating the mechanical forces required for their movement. The cytoskeleton orchestrates this process through the coordinated action of actin filaments, intermediate filaments, and microtubules. Examples of artificial cells that sense and adapt to changes in their environment owing to cytoskeleton rearrangement have extensively been explored. These efforts focus on the use of biomolecules that stochastically self-assemble in the lumen of an artificial cell. Here, we employ actin polymerizing nanomotors to assist cytoskeleton formation inside artificial cells. Nano- and micromotors are a class of active colloids that can self-propel outperforming Brownian motion. Inspired by natures' way of leveraging biopolymerization reactions to sustain locomotion in microorganisms or in organelles within cells, we imitate the mechanism of motion of the food-born bacteria Listeria monocytogenes. Specifically, we coat polystyrene particles with an actin recruiting protein that allows for actin filament polymerization in a mammalian cell lysate environment. This polymerization results in up to a 3-fold increase in the propulsion of the motors compared to their Brownian motion. Lastly, we show that these motors can be encapsulated inside hybrid vesicle-based artificial cells made of amphiphilic block copolymers and phospholipids, forming actin filaments that assemble into a cytoskeleton-like network. Taken together, this effort highlights the synergistic integration of bottom-up synthetic biology and active matter, demonstrating how their convergence can advance the design of life-like systems.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"31 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reprocessable and Recyclable Cellulosic Network Polymers with Intrinsic Flame Retardancy via Dynamic Covalent Cross-Linking 通过动态共价交联制备具有内在阻燃性的可再加工和可回收纤维素网络聚合物

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-16 DOI: 10.1021/acsnano.5c16164

Guowen Zhou, Zhixing Huang, Ruotong Du, Zepeng Lei, Xiaohui Wang

{"title":"Reprocessable and Recyclable Cellulosic Network Polymers with Intrinsic Flame Retardancy via Dynamic Covalent Cross-Linking","authors":"Guowen Zhou, Zhixing Huang, Ruotong Du, Zepeng Lei, Xiaohui Wang","doi":"10.1021/acsnano.5c16164","DOIUrl":"https://doi.org/10.1021/acsnano.5c16164","url":null,"abstract":"Developing sustainable, high-performance biobased materials is critical for reducing dependence on petroleum-derived plastics. Cellulose is the most abundant and renewable polymer resource, yet current cellulose-based materials often suffer from limitations such as flammability, water sensitivity, limited processability, and recyclability in practical use. Herein, we propose an integrated strategy to reconfigure cellulose’s hydrogen-bonded network into a dynamic covalent architecture while incorporating flame-retardant units in situ. The resulting thermo-processable cellulosic network polymers (CAA–DDPNs) exhibit high tensile strength (46–65 MPa), self-extinguishing behavior, and resistance to both water and common organic solvents. Compared with several engineering plastics, CAA-DDPN films demonstrate higher thermal stability (onset 281–301 °C) and an ultralow coefficient of thermal expansion (0.9–1.8 ppm K–1). More importantly, the dynamic linkers enable efficient chemical depolymerization to recover monomers, thereby overcoming the limited chemical recyclability of prior cellulose materials. The combination of mechanical robustness, thermal and chemical resilience, flame retardancy, and circularity makes CAA-DDPNs a viable, eco-friendly alternative to conventional petroleum-based plastics.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"10 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145295413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local Microenvironment-Induced Dynamic Self-Adaptation for High-Performance Ammonium-Ion Batteries. 高性能铵离子电池局部微环境诱导的动态自适应。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-16 DOI: 10.1021/acsnano.5c11361

Zhongzhuo Yang,Hanwen Cheng,Wei Yang,Yuanhao Shen,Yu Ding,Libin Diao,Shijie Feng,Lin Xu

{"title":"Local Microenvironment-Induced Dynamic Self-Adaptation for High-Performance Ammonium-Ion Batteries.","authors":"Zhongzhuo Yang,Hanwen Cheng,Wei Yang,Yuanhao Shen,Yu Ding,Libin Diao,Shijie Feng,Lin Xu","doi":"10.1021/acsnano.5c11361","DOIUrl":"https://doi.org/10.1021/acsnano.5c11361","url":null,"abstract":"Rechargeable aqueous ammonium-ion batteries (AIBs) have emerged as a highly promising energy storage system due to their safety and cost-effective sustainability. However, the design of AIBs electrodes that exhibit high-rate capability and a long cycle life to meet practical requirements is difficult. To address this challenge, we propose a local microenvironment-induced dynamic self-adaptation strategy. By constructing an amorphous layer in the microenvironment region of the vanadium oxide surface, we demonstrate that the local chemical microenvironment triggers reversible structural evolution during NH4+ de/intercalation. The tailored microenvironment at crystalline-amorphous interfaces spontaneously generates self-adaptive domains that dynamically counteract cycling-induced stresses and accelerate electron conduction. Therefore, the SR-VO half-cell achieves exceptional cycling stability and rate performance (an ultralow decay rate of 0.004% per cycle at 10 A g-1 after 10,000 cycles with 83.4 mAh g-1). The full cell integrating SR-VO with a high-entropy Prussian blue cathode demonstrates practical viability by powering wearable devices. This work highlights the critical role of heterostructure engineering in overcoming AIBs material limitations and advancing their practical applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"64 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curvature-Sensing Peptides for Virus and Extracellular Vesicle Applications 曲率传感肽在病毒和细胞外囊泡中的应用

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-16 DOI: 10.1021/acsnano.5c08239

Chang-Jun Lee, Fadilatul Jannah, Tun Naw Sut, Muhammad Haris, Joshua A. Jackman

{"title":"Curvature-Sensing Peptides for Virus and Extracellular Vesicle Applications","authors":"Chang-Jun Lee, Fadilatul Jannah, Tun Naw Sut, Muhammad Haris, Joshua A. Jackman","doi":"10.1021/acsnano.5c08239","DOIUrl":"https://doi.org/10.1021/acsnano.5c08239","url":null,"abstract":"Membrane curvature is a key biophysical feature that regulates diverse biological processes. A wide range of natural proteins have distinct structural motifs that can sense membrane curvature and function independently as curvature-sensing peptides. In recent years, such peptides have demonstrated excellent potential for selectively capturing and disrupting enveloped viruses and extracellular vesicles (EVs), which are in the ∼30–300 nm size range and possess highly curved membranes. Despite extensive progress, there is an outstanding need to categorize different curvature-sensing motifs and link them to tailored peptide designs for specific applications. Herein, we introduce membrane curvature sensing as a unifying selectivity principle to target enveloped viruses and EVs, and critically evaluate the structural and mechanistic features of curvature-sensing motifs to develop a four-type classification framework that spans membrane binding and disruption. These efforts are supported by foundational studies and the latest insights obtained from experimental, theoretical, and simulation approaches as well as machine learning-aided thermodynamic modeling. According to this framework, we analyze recent advances to engineer curvature-sensing peptides for emerging applications such as one-step diagnostic capture, rapid virus quantification, antiviral and anti-EV therapies, and genome-wide screening of bacterial EV regulators. In turn, we illustrate how design parameters such as amino acid composition, conformational dynamics, and interfacial force balancing (e.g., electrostatics vs hydrophobicity) guide functional performance. These insights lead us to propose future directions for curvature-sensing peptide engineering and highlight outstanding scientific questions and translational opportunities.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"93 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145295410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic Behavior of Bound Interlayer Excitons in Interlayer-Doped Cs3Bi2Br9 Vacancy-Ordered Perovskite 空位有序钙钛矿Cs3Bi2Br9层间掺杂层间激子的动力学行为

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-16 DOI: 10.1021/acsnano.5c14651

Kyeongdeuk Moon, Yang Ding, Halyna Okrepka, Rihan Wu, Caitlin N. Ewald, Pushpender Yadav, Anupam Biswas, Elad Harel, Masaru Kuno, Seokhyoung Kim

{"title":"Dynamic Behavior of Bound Interlayer Excitons in Interlayer-Doped Cs3Bi2Br9 Vacancy-Ordered Perovskite","authors":"Kyeongdeuk Moon, Yang Ding, Halyna Okrepka, Rihan Wu, Caitlin N. Ewald, Pushpender Yadav, Anupam Biswas, Elad Harel, Masaru Kuno, Seokhyoung Kim","doi":"10.1021/acsnano.5c14651","DOIUrl":"https://doi.org/10.1021/acsnano.5c14651","url":null,"abstract":"Interlayer doping of the vacancy-ordered 2D perovskite Cs3Bi2Br9 (CBB) enables the formation of bound interlayer excitons (BIEs), a unique charge-transfer excited state within the layered solid. BIEs previously reported with silver (Ag+) as an interlayer dopant exhibited bright broadband photoluminescence (PL) with prolonged lifetime at room temperature, offering potential applications in efficient white light emission, photocatalysis, and optoelectronics. However, the dynamic behavior of radiation and excited carriers remains poorly understood due to the limitations of ensemble spectroscopic measurements. Here, we investigate the temperature-dependent dynamics of Ag-doped Cs3Bi2Br9 (Ag-CBB) using single-particle time-resolved PL spectroscopy and ultrafast transient absorption imaging. Single-particle PL measurements reveal three distinct emission regimes across temperature: (i) BIE-dominant emission at high temperatures, (ii) a mixture of radiation from BIEs and self-trapped excitons (STEs) at intermediate temperatures, and (iii) STE-dominant emission below 100 K. Rapid transient absorption mapping using Parallel Rapid Imaging with Spectroscopic Mapping (PRISM) reveals subpicosecond STE formation in pristine CBB and long-lived photoinduced absorption by BIEs, consistent with electron–hole separation and suppressed STE transfer. The spatial uniformity of these signals confirms homogeneous Ag doping across single crystals. These findings highlight the role of Ag interlayer dopants in governing the BIE dynamics.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"27 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145295412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine-Assisted Inverse Design of Patchy Particles for Self-Assembly of Archimedean Tilings. 阿基米德瓷砖自组装中斑块粒子的机器辅助反设计。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-16 DOI: 10.1021/acsnano.5c10787

Yiwei Xu,Xin You,Tinghao Xu,Xuewei Dong,Bing Yuan,Kai Yang

{"title":"Machine-Assisted Inverse Design of Patchy Particles for Self-Assembly of Archimedean Tilings.","authors":"Yiwei Xu,Xin You,Tinghao Xu,Xuewei Dong,Bing Yuan,Kai Yang","doi":"10.1021/acsnano.5c10787","DOIUrl":"https://doi.org/10.1021/acsnano.5c10787","url":null,"abstract":"Self-assembly holds great promise for the development of next-generation materials with highly ordered micro- or nanoscale structures. A primary challenge involves the efficient exploration of high-dimensional parameter spaces to achieve user-desired architectures. In this study, we developed an inverse design strategy for the self-assembly of various Archimedean tilings using one-component patchy particles. The cornerstone of our approach resides in the seamless integration of design space decomposition with machine-assisted optimization techniques and specialized simulation evolution pathways, culminating in a stepwise modular protocol for determining critical particle attributes. Specifically, we employed a genetic algorithm-based backward evolution learning protocol followed by a Bayesian-based forward optimization protocol to sequentially determine the patch position and binding strength of the patchy particle. Consequently, the self-assembly of various Archimedean tilings and even more intricate exotic superlattices was successfully realized at a reduced computational cost. Moreover, our strategy showcases a robust capability to explore the design space, offering simplified or enhanced design schemes for target structures. Overall, our work advances inverse design strategies for fabricating intricately structured and high-performance interfacial materials within the scope of patchy particle models.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"47 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Illuminating the Underlying Mechanism of Intracellular Optoelectronic Modulation Using Silicon Nanowires. 利用硅纳米线阐明细胞内光电调制的潜在机制。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-16 DOI: 10.1021/acsnano.5c11146

Tania Assaf,Layan Habib,Adi Sasson,Shiri Karni-Ashkenazi,Menahem Y Rotenberg

{"title":"Illuminating the Underlying Mechanism of Intracellular Optoelectronic Modulation Using Silicon Nanowires.","authors":"Tania Assaf,Layan Habib,Adi Sasson,Shiri Karni-Ashkenazi,Menahem Y Rotenberg","doi":"10.1021/acsnano.5c11146","DOIUrl":"https://doi.org/10.1021/acsnano.5c11146","url":null,"abstract":"Strategies to electrically stimulate cells with subcellular resolution while minimizing invasiveness have the potential to revolutionize bioelectronic research. Optoelectronics, and particularly silicon nanowires (SiNWs), offer such capabilities due to their biocompatibility, spontaneous internalization, and photoelectrochemical properties. However, the underlying mechanisms by which SiNWs can optically induce intracellular calcium transients remain unclear. In this study, we mechanistically investigated these mechanisms. First, by depleting intracellular calcium stores, we demonstrated that intracellular, rather than extracellular, calcium is the source of optically induced calcium transients. Thereafter, to decouple the photothermal and photoelectrochemical contributions, we used intrinsic, photoanodic (n-i-p), or photocathodic (p-i-n) SiNWs. Our data shows that both photoanodic and photocathodic interfaces generated more significant calcium responses than the pure photothermal effect. For the photoelectrochemical response, reactive oxygen species (ROS) were found to dominate the photoanodic response, offering a potential strategy to tune oxidative stress responses. On the other hand, the photocathodic response modulated intracellular calcium via voltage-gated and calcium-sensitive channels of intracellular organelles, as evidenced by pharmacological inhibition of key organelles and signaling pathways. This work provides mechanistic insight into SiNW-mediated intracellular modulation, offering fundamental knowledge for the development of SiNW-based, leadless optoelectronic systems that enable precise and cell-specific interrogation within 3D biological constructs. These findings enable the application of safe, efficient, and spatially precise intracellular bioelectric modulation with enhanced subcellular resolution.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"59 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoscale Precise Stamping of Biomolecule Patterns Using DNA Origami 利用DNA折纸技术在纳米尺度上精确冲压生物分子模式

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-16 DOI: 10.1021/acsnano.5c07651

Laura Teodori, Ali Shahrokhtash, Elisabeth A. Sørensen, Xialin Zhang, Mette G. Malle, Duncan S. Sutherland, Jørgen Kjems

{"title":"Nanoscale Precise Stamping of Biomolecule Patterns Using DNA Origami","authors":"Laura Teodori, Ali Shahrokhtash, Elisabeth A. Sørensen, Xialin Zhang, Mette G. Malle, Duncan S. Sutherland, Jørgen Kjems","doi":"10.1021/acsnano.5c07651","DOIUrl":"https://doi.org/10.1021/acsnano.5c07651","url":null,"abstract":"Understanding the importance of ligand patterning in biological processes requires precise control over molecular positioning and spacing. While DNA origami structures offer nanoscale precision in biomolecule arrangement, their biological applications are limited by challenges related to their structural stability, scalability, and surface area. Here, we present a straightforward and rapid DNA origami stamping technique for transferring nanoscale oligonucleotide patterns onto surfaces, visualized using DNA-PAINT super-resolution microscopy to quantitatively assess the stamping efficiency and precision across different stamp types. Unlike traditional top-down methods that require specialized equipment, our technique provides an accessible, self-assembled platform for surface patterning, with versatility across various substrates via modifiable pattern-transfer oligonucleotides. We demonstrate reliable, efficient, and precise pattern transfer at single-molecule resolution, opening opportunities to study distance-dependent biological processes, including receptor activation, multivalent binding, and enzymatic cascades across broader spatial scales and different detection techniques. The use of the passivated surface limits nonspecific interactions with unpatterned areas and enables control over the interaction between the biological target and the patterned biomolecules. Our method advances surface patterning by combining DNA nanotechnology with single-molecule imaging techniques, expanding access to cost-effective analytical approaches and potentially enabling multiplexed detection and live measurements.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"27 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0