ACS Nano最新文献_第2页

Low-Cost Preparation of Wafer-Scale Au(111) Single Crystals for the Epitaxy of Two-Dimensional Layered Materials

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c17431

Jingyi Hu, Jialong Wang, Pengfei Yang, Wenzhi Quan, Xuan Wang, Haoxuan Ding, Jiatian Fu, You Peng, Ronghua Zhang, Honggang Wang, Liming Xie, Ke He, Lili Wang, Wei Wei, Leining Zhang, Zhongfan Liu, Yanfeng Zhang

{"title":"Low-Cost Preparation of Wafer-Scale Au(111) Single Crystals for the Epitaxy of Two-Dimensional Layered Materials","authors":"Jingyi Hu, Jialong Wang, Pengfei Yang, Wenzhi Quan, Xuan Wang, Haoxuan Ding, Jiatian Fu, You Peng, Ronghua Zhang, Honggang Wang, Liming Xie, Ke He, Lili Wang, Wei Wei, Leining Zhang, Zhongfan Liu, Yanfeng Zhang","doi":"10.1021/acsnano.4c17431","DOIUrl":"https://doi.org/10.1021/acsnano.4c17431","url":null,"abstract":"Single-crystal Au(111), renowned for its chemically inert surface, long-range “herringbone” reconstruction, and high electrical conductivity, has long served as an exemplary template in diverse fields, e.g., crystal epitaxy, electronics, and electrocatalysis. However, commercial Au(111) products are high-priced and limited to centimeter sizes, largely restricting their broad applications. Herein, a low-cost, high-reproducible method is developed to produce 4 in. Au(111) single crystals from commercial Au foils, via an abnormal grain growth process. This methodology involves the initial preparation of a (100)-textured Au polycrystalline foil, followed by the evolution and continuous expansion of an Au(111) abnormal grain through one-site stress loading and stress-relief annealing in an Ar/H2 atmosphere. Theoretical simulations indicate that stress/strain and high-temperature treatments in the H2 atmosphere induce an intermediate disordered state, facilitating the evolution from polycrystalline Au(100) foil to single-crystal Au(111) foil. Furthermore, the resulting Au(111) foils have been utilized as model substrates for the oriented growth of two-dimensional transition metal dichalcogenides and their heterostructures with graphene. This work hereby puts forward an effective approach for large-scale, cost-effective production of metal single crystals, potentially revolutionizing their applications across various fields, from materials sciences to electronics and catalysis.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"139 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scalable Fabrication of Freestanding Jammed Nanoparticle Films via Pickering Emulsion-Mediated Interfacial Assembly

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c13566

Jieun Heo, Seunghwan Seo, Juyoung Lee, Kang Hee Ku

{"title":"Scalable Fabrication of Freestanding Jammed Nanoparticle Films via Pickering Emulsion-Mediated Interfacial Assembly","authors":"Jieun Heo, Seunghwan Seo, Juyoung Lee, Kang Hee Ku","doi":"10.1021/acsnano.4c13566","DOIUrl":"https://doi.org/10.1021/acsnano.4c13566","url":null,"abstract":"Freestanding networked nanoparticle (NP) films hold substantial potential due to their high surface areas and customizable porosities. However, NPs with high surface energies and heterogeneous sizes or shapes present considerable challenges as they tend to aggregate, compromising their structural integrities. In this study, we report the scalable fabrication of ultrathin, bicontinuous, and densely packed carbon NP films via Pickering emulsion-mediated interfacial assembly. This method enables the efficient transfer of closely packed NP networks from emulsions to air–water interface and ultimately to diverse substrates, which provides broad versatility for tailored applications. Utilizing the jamming structures of NPs at the fluid interface, we achieve precise control over film size with homogeneous thickness while minimizing material waste and facilitating recyclability. Notably, the films can be smoothly transferred to micropatterned, stretchable, and complex three-dimensional substrates, enabling the realization of robust conformal coatings. The resulting films exhibit high structural stability and flexibility, demonstrating significant potential for the design of stretchable and flexible devices.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"12 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond CO2 Storage: Enzyme-Amyloid Fibril Catalytic Hybrids for Long Cascade Reactions Converting CO2 into Fructose

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c15808

Tonghui Jin, Sophally Chhong, Mingqin Li, Jiangtao Zhou, Qize Xuan, Jiaqi Su, Ming Dai, Mohammad Peydayesh, Zhou Dong, Qiyao Sun, Mattia Usuelli, Raffaele Mezzenga

{"title":"Beyond CO2 Storage: Enzyme-Amyloid Fibril Catalytic Hybrids for Long Cascade Reactions Converting CO2 into Fructose","authors":"Tonghui Jin, Sophally Chhong, Mingqin Li, Jiangtao Zhou, Qize Xuan, Jiaqi Su, Ming Dai, Mohammad Peydayesh, Zhou Dong, Qiyao Sun, Mattia Usuelli, Raffaele Mezzenga","doi":"10.1021/acsnano.4c15808","DOIUrl":"https://doi.org/10.1021/acsnano.4c15808","url":null,"abstract":"Enzyme immobilization is an efficient and cost-effective approach to recovering, stabilizing, and enhancing enzyme catalytic properties. It is a challenge, however, for coimmobilized multiple enzymes to perform consecutive reactions without being inactivated under similar conditions. Here, we present a facile enzyme immobilization platform using β-lactoglobulin amyloid fibril hydrogels. Two different hydrogels, loading either RuBisCO alone (hereby termed AFR*) or seven enzymes related to the Calvin Cycle (hereby termed AF7E hydrogel), show immobilization efficiency of over ∼95% while simultaneously exhibiting excellent activity and stability. The AFR* hydrogel enables the fixation of CO2 into 3-phosphoglycerate (3-PGA), which is then utilized as the initial step in the Calvin Cycle cascade catalytic reactions if the AF7E hydrogel is used, mimicking the light-independent part of the more complex natural photosynthesis full process. The converted substrates of this process contain precursors (α-glycerophosphate dehydrogenase and dihydroxyacetone phosphate), which can be further converted to fructose by additional aldolase. Due to the proteinaceous nature of the amyloid substrate, the AF7E hydrogel is completely biodegradable by pepsin, as confirmed via atomic force microscopy and circular dichroism spectroscopy analysis. This original enzyme-amyloid hybrid is biocompatible, sustainable, and scalable and may serve as a general template for multienzymatic catalytic platforms.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"77 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoenzyme-Anchored Mitofactories Boost Mitochondrial Transplantation to Restore Locomotor Function after Paralysis Following Spinal Cord Injury

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c12557

Runxiu Wei, Yiman Chen, Qiang Yang, Tongge Wang, Yanyun He, Na Yin, Liya Yang, Yifei Gao, Ling Guo, Min Feng

{"title":"Nanoenzyme-Anchored Mitofactories Boost Mitochondrial Transplantation to Restore Locomotor Function after Paralysis Following Spinal Cord Injury","authors":"Runxiu Wei, Yiman Chen, Qiang Yang, Tongge Wang, Yanyun He, Na Yin, Liya Yang, Yifei Gao, Ling Guo, Min Feng","doi":"10.1021/acsnano.4c12557","DOIUrl":"https://doi.org/10.1021/acsnano.4c12557","url":null,"abstract":"Mitochondrial transplantation is a significant therapeutic approach for addressing mitochondrial dysfunction in patients with spinal cord injury (SCI), yet it is limited by rapid mitochondrial deactivation and low transfer efficiency. Here, high-quality mitochondria microfactories (HQ-Mitofactories) were constructed by anchoring Prussian blue nanoenzymes onto mesenchymal stem cells for effective mitochondrial transplantation to treat paralysis from SCI. Notably, the results demonstrated that HQ-Mitofactories could continuously produce vitality-boosting mitochondria with highly interconnected and elongated network structures under oxidative stress by scavenging excessive ROS. Furthermore, HQ-Mitofactories enabled efficient transfer of therapeutic mitochondria to injured neurons primarily via gap junctions, resulting in the restoration of mitochondrial homeostasis and thereby suppressing intracellular ROS burst and facilitating neuronal repair. After i.v. administration, HQ-Mitofactories migrated to the injured spinal cords of SCI mice and subsequently promoted neuronal regeneration and remyelination. Consequently, HQ-Mitofactory-treated mice successfully recovered locomotor function within 4 weeks, with 40% of the mice fully restoring walking after hindlimb paralysis. Conversely, untreated SCI exhibited completely abolished hindlimb movements. In light of real-time generation of vitality-boosting mitochondria even under oxidative stress and enabling targeted mitochondrial transfer, HQ-Mitofactories have promising therapeutic potential in the context of mitochondrial transplantation to reduce SCI-related paralysis, and more broadly impact the field of neuroregenerative medicine.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"15 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold Single Atom Doped Defective Nanoporous Copper Octahedrons for Electrocatalytic Reduction of Carbon Dioxide to Ethylene

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c13961

Yang Zhao, Yanan Wang, Zhipeng Yu, Chao Song, Jingwei Wang, Haoliang Huang, Lijian Meng, Miao Liu, Lifeng Liu

{"title":"Gold Single Atom Doped Defective Nanoporous Copper Octahedrons for Electrocatalytic Reduction of Carbon Dioxide to Ethylene","authors":"Yang Zhao, Yanan Wang, Zhipeng Yu, Chao Song, Jingwei Wang, Haoliang Huang, Lijian Meng, Miao Liu, Lifeng Liu","doi":"10.1021/acsnano.4c13961","DOIUrl":"https://doi.org/10.1021/acsnano.4c13961","url":null,"abstract":"Electrocatalytic CO2 reduction into high-value multicarbon products offers a sustainable approach to closing the anthropogenic carbon cycle and contributing to carbon neutrality, particularly when renewable electricity is used to power the reaction. However, the lack of efficient and durable electrocatalysts with high selectivity for multicarbons severely hinders the practical application of this promising technology. Herein, a nanoporous defective Au1Cu single-atom alloy (De-Au1Cu SAA) catalyst is developed through facile low-temperature thermal reduction in hydrogen and a subsequent dealloying process, which shows high selectivity toward ethylene (C2H4), with a Faradaic efficiency of 52% at the current density of 252 mA cm–2 under a potential of −1.1 V versus reversible hydrogen electrode (RHE). In situ spectroscopy measurements and density functional theory (DFT) calculations reveal that the high C2H4 product selectivity results from the synergistic effect between Au single atoms and defective Cu sites on the surface of catalysts, where Au single atoms promote *CO generation and Cu defects stabilize the key intermediate *OCCO, which altogether enhances C–C coupling kinetics. This work provides important insights into the catalyst design for electrochemical CO2 reduction to multicarbon products.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"57 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors that Affect Quantification in Surface-Enhanced Raman Scattering

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c15183

Meikun Fan, Alexandre G. Brolo

引用次数: 0

Precision Metal Nanoclusters Meet Proteins: Crafting Next-Gen Hybrid Materials

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c15366

Bihan Zhang, Zhenghan Liu, Ruixuan Zhang, Qiaofeng Yao, Jianping Xie

{"title":"Precision Metal Nanoclusters Meet Proteins: Crafting Next-Gen Hybrid Materials","authors":"Bihan Zhang, Zhenghan Liu, Ruixuan Zhang, Qiaofeng Yao, Jianping Xie","doi":"10.1021/acsnano.4c15366","DOIUrl":"https://doi.org/10.1021/acsnano.4c15366","url":null,"abstract":"Metal nanoclusters (NCs), owing to their atomic precision and unique molecule-like properties, have gained widespread attention for applications ranging from catalysis to bioimaging. In recent years, proteins, with their hierarchical structures and diverse functionalities, have emerged as good candidates for functionalizing metal NCs, rendering metal NC–protein conjugates with combined and even synergistically enhanced properties featured by both components. In this Perspective, we explore key questions regarding why proteins serve as complementary partners for metal NCs, the methodologies available for conjugating proteins with metal NCs, and the characterization techniques necessary to elucidate the structures and interactions within this emerging bionano system. We also highlight the emerging applications of metal NC–protein conjugates in biomedicine, catalysis, and biosensing in which the hybrid conjugates demonstrate remarkable performance. Furthermore, key challenges hampering further development of metal NC–protein conjugates, which include understanding binding mechanisms, expanding the diversity of proteins used for conjugation, and exploiting the individual roles of metal NCs and proteins within the hybrid systems, are discussed. This Perspective aims to systemize current synthetic methodologies and design principles for metal NC–protein conjugates, adding to their acceptance in precision nanotechnology.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"206 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoplasmic Reticulum-Targeted Polymer-Manganese Nanocomplexes for Tumor Immunotherapy

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c17279

Haoru Zhu, Chang Xu, Yu Geng, Youqing Shen, Nasha Qiu

{"title":"Endoplasmic Reticulum-Targeted Polymer-Manganese Nanocomplexes for Tumor Immunotherapy","authors":"Haoru Zhu, Chang Xu, Yu Geng, Youqing Shen, Nasha Qiu","doi":"10.1021/acsnano.4c17279","DOIUrl":"https://doi.org/10.1021/acsnano.4c17279","url":null,"abstract":"Manganese ions (Mn2+) are an immune activator that enhances the activation of both cGAS and STING proteins. The STING signaling activation and subsequential immune responses are predominantly associated with endoplasmic reticulum (ER). Therefore, ER targeting of Mn2+ in the subcellular compartments would promote the activation of STING signaling pathways. Herein, we report the design of ER-targeted manganese-based nanocomplexes (NCs) by complexation of Mn2+ with a zwitterionic polymer, poly[2-(N-oxide-N,N-dimethylamino) ethyl methacrylate] (OPDMA). The Mn/OPDMA nanocomplexes (Mn/OPDMA NCs) keep a long blood circulation for tumor accumulation and trigger adsorption-mediated transcytosis for extravasation and deep tumor penetration. Notably, in the tumor-associated macrophages, the Mn/OPDMA NCs can preferentially translocate to their ERs, significantly enhancing cGAS-STING pathway activation for tumor-associated macrophage polarization and IFN-β secretion. In mouse colon and hepatocellular cancer models, the intravenously administrated Mn/OPDMA NCs efficiently remodel tumor immune microenvironment, greatly retard tumor growths by 2.4- to 5-fold, and prolong the mouse survivals compared to free Mn2+-treated mice. This study provides the ER-targeted delivery of Mn2+ that achieves robust STING activation and, thus, potent systemic tumor inhibition without the toxicity of free Mn2+.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"25 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Characterization of the Platinum Nanoparticle Hydrogen-Evolving Catalyst Assembled on Photosystem I by Light-Driven Chemistry 光驱动化学在光系统I上组装的铂纳米粒子析氢催化剂的结构表征

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-23 DOI: 10.1021/acsnano.4c08563

Nina S. Ponomarenko, Nestor J. Zaluzec, Xiaobing Zuo, Olaf J. Borkiewicz, Justin M. Hoffman, Gihan Kwon, Alex B. F. Martinson, Lisa M. Utschig, David M. Tiede

{"title":"Structural Characterization of the Platinum Nanoparticle Hydrogen-Evolving Catalyst Assembled on Photosystem I by Light-Driven Chemistry","authors":"Nina S. Ponomarenko, Nestor J. Zaluzec, Xiaobing Zuo, Olaf J. Borkiewicz, Justin M. Hoffman, Gihan Kwon, Alex B. F. Martinson, Lisa M. Utschig, David M. Tiede","doi":"10.1021/acsnano.4c08563","DOIUrl":"https://doi.org/10.1021/acsnano.4c08563","url":null,"abstract":"Directed assembly of abiotic catalysts onto biological redox protein frameworks is of interest as an approach for the synthesis of biohybrid catalysts that combine features of both synthetic and biological materials. In this report, we provide a multiscale characterization of the platinum nanoparticle (NP) hydrogen-evolving catalysts that are assembled by light-driven reductive precipitation of platinum from an aqueous salt solution onto the photosystem I protein (PSI), isolated from cyanobacteria as trimeric PSI. The resulting PSI-NP assemblies were analyzed using a combination of X-ray energy-dispersive spectroscopy (XEDS), high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), small-angle X-ray scattering (SAXS), and high-energy X-ray scattering with atomic pair distribution function (PDF) analyses. The results show that the PSI-supported NPs are approximately 1.8 nm diameter disk-shaped particles that assemble at discrete sites with 145 Å separation. This separation is too large to be consistent with NP nucleation and growth at a site adjacent to the FB cofactor site. Instead, we suggest a mechanism for NP growth at hydrophobic sites on the PSI stromal surface. The NPs photoreductively assembled on the PSI stromal surface are found to be analogous to the nanostructures produced by successive cycles of atomic layer deposition (ALD) of platinum onto 40 nm porous anodic alumina oxide supports, although the mechanisms for nucleation appear to differ. This work establishes a foundation for the investigation of the reductive assembly of abiotic metal catalysts at sites connected to photochemically reducing equivalent production in PSI.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"103 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reductive Adjuvant Nanosystem for Alleviated Atopic Dermatitis Syndromes 减轻特应性皮炎综合征的还原佐剂纳米系统

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-23 DOI: 10.1021/acsnano.4c08767

Yichao Lu, Xinyu Shan, Jiaxin Huang, Huanli Zhou, Ying Zhu, Sijie Wang, Zhenyu Luo, Xu Liu, Xuemeng Guo, Yingying Shi, Yilong Hu, Huihui Liu, Junlei Zhang, Ping Huang, Lihua Luo, Jian You

{"title":"Reductive Adjuvant Nanosystem for Alleviated Atopic Dermatitis Syndromes","authors":"Yichao Lu, Xinyu Shan, Jiaxin Huang, Huanli Zhou, Ying Zhu, Sijie Wang, Zhenyu Luo, Xu Liu, Xuemeng Guo, Yingying Shi, Yilong Hu, Huihui Liu, Junlei Zhang, Ping Huang, Lihua Luo, Jian You","doi":"10.1021/acsnano.4c08767","DOIUrl":"https://doi.org/10.1021/acsnano.4c08767","url":null,"abstract":"Atopic dermatitis (AD) is a recurrent and chronic inflammatory skin condition characterized by a high lifetime prevalence and significant impairment of patients’ quality of life, primarily due to intense itching and discomfort. However, current pharmacological interventions provide only moderate efficacy and are frequently accompanied by adverse side effects. The immune-pathogenesis of AD involves dysregulation of the Th2 immune response and exacerbation of inflammation related to excessive reactive oxygen species (ROS). Therefore, to address these issues, in this study, we targeted the upstream pathogenesis by designing a pro-Th1 adjuvant nanoemulsion loaded with poly(I:C) and encapsulated with the ROS-scavenger vitamin E, termed PV-NE. PV-NE effectively rebalanced the Th1/Th2 immune response and reduced ROS levels both in vivo and ex vivo, leading to the restoration of immune balance in AD-affected skin and alleviation of symptoms such as lichenification and erythematous patches. In conclusion, our development of the reductive adjuvant nanosystem PV-NE demonstrates its biocompatibility and efficacy in combating AD progression without the use of immunosuppressant glucocorticoids. This has the potential to significantly impact the design and enhancement of pharmacotherapy in future clinical research aimed at curing AD.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"206 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0