ACS Nano最新文献_第3页

Midinfrared Electroluminescence from CdSe Quantum Dots

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-02-02 DOI: 10.1021/acsnano.4c18113

Xingyu Shen, Philippe Guyot-Sionnest

引用次数: 0

Cuproptosis-Inducing Functional Nanocomposites for Enhanced and Synergistic Cancer Radiotherapy

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-02-02 DOI: 10.1021/acsnano.4c13753

Tiaoyan Jiang, Tianying Jia, Yipengchen Yin, Tianyu Li, Xinran Song, Wei Feng, Sheng Wang, Li Ding, Yu Chen, Qin Zhang

{"title":"Cuproptosis-Inducing Functional Nanocomposites for Enhanced and Synergistic Cancer Radiotherapy","authors":"Tiaoyan Jiang, Tianying Jia, Yipengchen Yin, Tianyu Li, Xinran Song, Wei Feng, Sheng Wang, Li Ding, Yu Chen, Qin Zhang","doi":"10.1021/acsnano.4c13753","DOIUrl":"https://doi.org/10.1021/acsnano.4c13753","url":null,"abstract":"Radiotherapy is crucial in local cancer management and needs advancements. Tumor cells elevate intracellular copper levels to promote growth and resist radiation; thus, targeted copper delivery to mitochondria could enhance radiotherapy by inducing cuproptosis in tumor cells. In this study, we engineered a multifunctional nanoliposome complex, termed Lipo-Ele@CuO2, which encapsulates both copper peroxide (CuO2) and the copper chelator elesclomol, which can delivery Cu ions to the mitochondria. The Lipo-Ele@CuO2 complex induces mitochondria-mediated cuproptosis in tumor cells and synergistically enhances the efficacy of radiotherapy. CuO2 acts as a copper donor and exhibits inherent sensitivity to acidic environments. Additionally, it depletes intracellular glutathione, thereby sensitizing cells to cuproptosis. Leveraging its pH-responsive properties in the acidic tumor microenvironment, the Lipo-Ele@CuO2 facilitate the controlled release of elesclomol, efficiently delivering copper ions to mitochondria at tumor sites. The combined in vitro and in vivo studies demonstrate that Lipo-Ele@CuO2-based therapy significantly improves antitumor efficacy and exhibits excellent safety profiles, effectively inducing cuproptosis in tumor cells and boosting the effectiveness of radiotherapy. Furthermore, metabolomic and transcriptomic analyses reveal that this combination therapy precipitates significant alterations in tumor energy metabolism, notably repressing genes related to iron–sulfur cluster assembly and glycolysis, thereby confirming the induction of cuproptosis. This therapeutic strategy provides a viable approach for addressing clinical radiotherapy resistance and demonstrates significant translational potential.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"7 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orthogonally Engineered Bacteria Capture Metabolically Labeled Tumor Antigens to Improve the Systemic Immune Response in Irradiated Tumors. 正交工程细菌捕获代谢标记的肿瘤抗原以改善辐照肿瘤的全身免疫反应

IF 15.8 1区材料科学

ACS Nano Pub Date : 2025-01-31 DOI: 10.1021/acsnano.4c13320

Wen Xia, Zhuo Feng, Yuchen Wang, Ruiqi Lei, Yao Zhou, Yujia Zhuo, Ran Xie, Hong Dong, Xiaozhi Zhao, Xiaoxiang Guan, Jinhui Wu

{"title":"Orthogonally Engineered Bacteria Capture Metabolically Labeled Tumor Antigens to Improve the Systemic Immune Response in Irradiated Tumors.","authors":"Wen Xia, Zhuo Feng, Yuchen Wang, Ruiqi Lei, Yao Zhou, Yujia Zhuo, Ran Xie, Hong Dong, Xiaozhi Zhao, Xiaoxiang Guan, Jinhui Wu","doi":"10.1021/acsnano.4c13320","DOIUrl":"https://doi.org/10.1021/acsnano.4c13320","url":null,"abstract":"In situ vaccination is considered a promising cancer immunotherapy strategy to elicit a tumor-specific T cell response. Live bacteria effectively enhanced the immune response in irradiated tumors as it can activate multiple immune cells. However, the adaptive immune response remains low since bacteria lack the efficient delivery of antigen to dendritic cells (DCs). Here, we show that tumor antigens can be metabolically labeled with azido groups in situ, allowing for their specific capture by orthogonally engineered Salmonella via bioorthogonal chemistry. Subsequently, these antigens are efficiently delivered to DCs through the active movement of the bacteria. Intratumorally injected engineered bacteria captured the labeled antigens and improved their presentation by DCs. This increased the proportion of antigen-specific CD8+ T cells in tumors, further resulting in systemic antitumor effects in the bilateral melanoma mouse model. The antitumor effects were abrogated in Batf3-/- mice or after CD8+ T cell depletion, indicating that systemic antitumor effects were dependent on adaptive immune responses. Overall, our work presents a strategy combining bacterial engineering and antigen labeling, which may guide the development of in situ vaccines in the future.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-Dimensionally Printed Ionogel-Coated Ceramic Electrolytes for Solid-State Lithium Batteries.

IF 15.8 1区材料科学

ACS Nano Pub Date : 2025-01-31 DOI: 10.1021/acsnano.4c17761

Liying Wei, Yan Feng, Shuhui Ge, Shujie Liu, Yanyan Ma, Jianhua Yan

{"title":"Three-Dimensionally Printed Ionogel-Coated Ceramic Electrolytes for Solid-State Lithium Batteries.","authors":"Liying Wei, Yan Feng, Shuhui Ge, Shujie Liu, Yanyan Ma, Jianhua Yan","doi":"10.1021/acsnano.4c17761","DOIUrl":"https://doi.org/10.1021/acsnano.4c17761","url":null,"abstract":"Stereolithography three-dimensional (3D) printing technology enables the customization of ceramic-based solid electrolyte structures with desired electrochemical properties; however, formulating slurries that both are highly ceramic-loaded and have low viscosity for printing poses a challenge. Here, we propose an ionogel-coated ceramic approach to prepare a shear-thinning fast-ion conductor ceramic (Li6.5La3Zr1.5Ta0.5O12) slurry, which possesses both a high ceramic content of 50 wt % and a low viscosity of 1.53 Pa·s. Utilizing this slurry, 3D symmetric honeycomb briquette-like electrolyte films are printed, and solid-state lithium batteries are easily fabricated by filling the cathode and anode slurries into the respective symmetric honeycombs. The atomic-level interaction between ceramic/ionogel interfaces and the integrated electrode/electrolyte interface facilitates rapid Li+ transport across multiscale interphases in batteries. Additionally, the interactions of ceramic nanoparticles and ionic liquids with Li salt substantially increase the concentration of free Li+, both of which enhance the ionic conductivity and ensure stable Li+ transport efficiency. Solid-state lithium batteries can cycle stably 500 times without obvious degradation at 0.5 C and 50 °C. The strategy offers a feasible solution for printing customized solid-state ceramic-based electrolytes.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal Ion and Antibiotic Co-loaded Nanoparticles for Combating Methicillin-Rresistant Staphylococcus aureus-Induced Osteomyelitis.

IF 15.8 1区材料科学

ACS Nano Pub Date : 2025-01-31 DOI: 10.1021/acsnano.4c11956

Hui Lv, Ming Yang, Yusheng Yang, Zhenzhen Tang, Yuan Guo, Jiangling Zhou, Yingtao Gui, Rong Huang, Juan Cai, Bo Yu, Jing Yang, Ying Bao, Zhongrong Zhang, Dinglin Zhang, Tianyong Hou

{"title":"Metal Ion and Antibiotic Co-loaded Nanoparticles for Combating Methicillin-Rresistant Staphylococcus aureus-Induced Osteomyelitis.","authors":"Hui Lv, Ming Yang, Yusheng Yang, Zhenzhen Tang, Yuan Guo, Jiangling Zhou, Yingtao Gui, Rong Huang, Juan Cai, Bo Yu, Jing Yang, Ying Bao, Zhongrong Zhang, Dinglin Zhang, Tianyong Hou","doi":"10.1021/acsnano.4c11956","DOIUrl":"https://doi.org/10.1021/acsnano.4c11956","url":null,"abstract":"Methicillin-resistant Staphylococcus aureus (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn2+ and vancomycin (Van) codelivered nanotherapeutic (named Man-Zn2+/Van NPs) was fabricated and characterized via mannose (Man) modification. Man-Zn2+/Van NPs exhibit significant inhibitory activity against extra- and intracellular MRSA and obviously decrease the minimum inhibitory concentration of Van. Man-Zn2+/Van NPs can be easily internalized by MRSA-infected macrophages and significantly accumulated in infected bone via Man-mediated targeting. In vivo experiments in a mouse OM model verified that Man-Zn2+/Van NPs significantly reduce the extra- and intracellular MRSA burden, improve gait patterns, increase bone mass, and decrease inflammatory cytokine expression. The antibacterial mechanism of Man-Zn2+/Van NPs includes destruction of the MRSA membrane, degeneration of intracellular proteins and DNA, inhibition of MRSA glycolysis, and intervention in the energy metabolism of bacteria. Overall, this metal-antibiotic nanotherapeutics strategy provides new insight for combating extra- and intracellular infections caused by MRSA-induced OM.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plexciton Photoluminescence in Strongly Coupled 2D Semiconductor-Plasmonic Nanocavity Hybrid. 强耦合二维半导体-光电纳米腔混合体中的反射子光致发光。

IF 15.8 1区材料科学

ACS Nano Pub Date : 2025-01-31 DOI: 10.1021/acsnano.4c15637

Zhengyi Lu, Dudu Song, Cidu Lin, Hao Zhang, Shunping Zhang, Hongxing Xu

{"title":"Plexciton Photoluminescence in Strongly Coupled 2D Semiconductor-Plasmonic Nanocavity Hybrid.","authors":"Zhengyi Lu, Dudu Song, Cidu Lin, Hao Zhang, Shunping Zhang, Hongxing Xu","doi":"10.1021/acsnano.4c15637","DOIUrl":"https://doi.org/10.1021/acsnano.4c15637","url":null,"abstract":"Strong plasmon-exciton interaction between two-dimensional transition metal dichalcogenides and a plasmonic nanocavity under ambient conditions has been reported extensively. But the suspicion on whether it has reached a true \"strong coupling\" is always there because the commonly used dark-field scattering spectroscopy shows a larger spectral splitting and the splitting in the photoluminescence spectra is absent. Here, by using a nanobipyramid-over-mirror to enhance the in-plane vacuum field, we achieve spectral Rabi splitting in both scattering and differential reflection spectra and observe a clear photoluminescence emission of the lower plexciton branch. The established nanocavity offers two polarization-dependent gap plasmon resonances to provide excitation and quantum yield enhancement simultaneously, yielding a total photoluminescence enhancement of 2.1 × 104 times. This allows the acquisition of emission spectra from an individual coupled system regardless of the presence of an uncoupled emitting background in the collection area. The sharp tips of the nanobipyramid lead to a large single-exciton coupling strength up to a few meV. Correlated scattering, differential reflection, and photoluminescence spectra reveal the similarity between the scattering and normalized photoluminescence spectra. These correlative measurements on a single coupled system clear up the suspicions of strong plasmon-exciton interactions and will promote the development of light-emitting plexcitonic devices at room temperature.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Cocrystal Strategy for Retinamorphic Vision with UV-Vis-NIR Perception and Fast Recognition.

IF 15.8 1区材料科学

ACS Nano Pub Date : 2025-01-31 DOI: 10.1021/acsnano.4c16251

Xue-Mei Dong, Chen Chen, Yin-Xiang Li, Hong-Chao Sun, Bin Liu, Zi-Fan Li, Kai-Li Wang, Zi-Xi He, Meng-Na Yu, Wei Huang, Ju-Qing Liu

引用次数: 0

Soft Nanomembrane Sensor-Enabled Wearable Multimodal Sensing and Feedback System for Upper-Limb Sensory Impairment Assistance.

IF 15.8 1区材料科学

ACS Nano Pub Date : 2025-01-31 DOI: 10.1021/acsnano.4c15530

Tae Woog Kang, Yoon Jae Lee, Bruno Rigo, Ira Soltis, Jimin Lee, Hodam Kim, Gaorong Wang, Nathan Zavanelli, Eyas Ayesh, Wali Sohail, Houriyeh Majditehran, Scott H Kozin, Frank L Hammond, Woon-Hong Yeo

{"title":"Soft Nanomembrane Sensor-Enabled Wearable Multimodal Sensing and Feedback System for Upper-Limb Sensory Impairment Assistance.","authors":"Tae Woog Kang, Yoon Jae Lee, Bruno Rigo, Ira Soltis, Jimin Lee, Hodam Kim, Gaorong Wang, Nathan Zavanelli, Eyas Ayesh, Wali Sohail, Houriyeh Majditehran, Scott H Kozin, Frank L Hammond, Woon-Hong Yeo","doi":"10.1021/acsnano.4c15530","DOIUrl":"https://doi.org/10.1021/acsnano.4c15530","url":null,"abstract":"Sensory rehabilitation in pediatric patients with traumatic spinal cord injury is challenging due to the ongoing development of their nervous systems. However, these sensory problems often result in nonuse of the impaired limb, which disturbs impaired limb rehabilitation and leads to overuse of the contralateral limb and other physical or psychological issues that may persist. Here, we introduce a soft nanomembrane sensor-enabled wearable glove system that wirelessly delivers a haptic sensation from the hand with tactile feedback responses for sensory impairment assistance. The smart glove system uses gold nanomembranes, copper-elastomer composites, and laser-induced graphene for the sensitive detection of pressure, temperature, and strain changes. The nanomaterial sensors are integrated with low-profile tactile actuators and wireless flexible electronics to offer real-time sensory feedback. The wearable system's thin-film sensors demonstrate 98% and 97% accuracy in detecting pressure and finger flexion, respectively, along with a detection coverage of real-life temperature changes as an effective rehabilitation tool. Collectively, the upper-limb sensory impairment assistance system embodies the latest in soft materials and wearable technology to incorporate soft sensors and miniaturized actuators and maximize its compatibility with human users, offering a promising solution for patient sensory rehabilitation.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorine-Free Nanofiber/Network Membranes with Interconnected Tortuous Channels for High-Performance Liquid-Repellency and Breathability.

IF 15.8 1区材料科学

ACS Nano Pub Date : 2025-01-31 DOI: 10.1021/acsnano.4c14213

Mingle Ding, Yuan Wang, Xiaobao Gong, Mukun Luo, Xia Yin, Jianyong Yu, Shichao Zhang, Bin Ding

{"title":"Fluorine-Free Nanofiber/Network Membranes with Interconnected Tortuous Channels for High-Performance Liquid-Repellency and Breathability.","authors":"Mingle Ding, Yuan Wang, Xiaobao Gong, Mukun Luo, Xia Yin, Jianyong Yu, Shichao Zhang, Bin Ding","doi":"10.1021/acsnano.4c14213","DOIUrl":"https://doi.org/10.1021/acsnano.4c14213","url":null,"abstract":"The excessive use of fluoride in fibrous membranes poses significant bioaccumulative threats to the environment and human health. However, most existing membranes used in protective clothing and desalination systems show high fluorine dependence and inevitable trade-offs between liquid repellency and breathability. Herein, fluorine-free bonded scaffolded nanofiber/network membranes are developed using the electro-coating-netting technique to achieve high-performance liquid-repellency and breathability. By manipulating the stretching of electrospun jets and the polarization of electrets, rough and electrostatic wetting nanofibers are obtained as scaffolds, on which long-chain alkyl precursors are coated to assemble 2D networks consisting of nanowires with diameters of ∼42 nm and bonding points. The resultant fluorine-free membranes exhibit small pore sizes of ∼460 nm, highly interconnected tortuous channels, a water contact angle of ∼138°, and elastic elongation up to 300%, thereby providing both high-performance liquid repellency (125 kPa) and vapor permeability (4206 g m-2 d-1), making them effective for use in protective clothing and desalination. This work could inspire innovative design of ecofriendly nanofibrous materials for high-performance filtration and separation.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rationally Engineered Bispecific Nanoimmunoblocker Restores Anticancer Immunity via Dual Immune Checkpoint Blockade.

IF 15.8 1区材料科学

ACS Nano Pub Date : 2025-01-31 DOI: 10.1021/acsnano.4c13463

Peixin Guan, Fang Jin, Anqi Zhang, Song Gao, Zhen Liu

{"title":"Rationally Engineered Bispecific Nanoimmunoblocker Restores Anticancer Immunity via Dual Immune Checkpoint Blockade.","authors":"Peixin Guan, Fang Jin, Anqi Zhang, Song Gao, Zhen Liu","doi":"10.1021/acsnano.4c13463","DOIUrl":"https://doi.org/10.1021/acsnano.4c13463","url":null,"abstract":"Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment. However, the outcomes of mainstay antibody inhibitors against solid tumors remain poor, facing tremendous challenges including manufacturing complexities, serious toxicities, and crosstalk among multiple checkpoints. Herein, we present a bispecific molecularly imprinted nanoimmunoblocker (bsMINIB) designed to boost potent antitumor immunity via synchronously blocking innate and adaptive immune checkpoints. Two epitopes for PD-L1 and SIRPα are selected as templates through structural analysis, and thereafter, bsMINIB capable of bridging tumor cells and macrophages is rationally engineered via an advanced imprinting approach. The bsMINIB exhibits high affinity and specificity toward PD-L1 on solid tumor cells and SIRPα on macrophages, allowing effective disruption of both PD-L1/PD-1 and CD47/SIRPα signaling. These signal disruptions restore macrophage-mediated tumor phagocytosis, promote tumor-associated antigen presentation, and reinvigorate T cell-mediated tumor killing. Using refractory triple-negative breast cancer as a solid tumor model, the bsMINIB demonstrates extended retention at the tumor site, amplified infiltration of active T cells, and reactivated antitumor macrophages, thereby effectively inhibiting tumor growth. This biomimetic nanoimmunoblocker not only presents an effective multipronged ICB therapeutic against solid tumors but also showcases a compelling paradigm for the rational engineering of bispecific nanoplatforms for synergistic immunotherapy through molecular imprinting.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0