ACS Nano最新文献_第3页

Engineering Amorphous/Crystalline Ni/NiO Electrocatalysts for Highly Efficient Hydrogen Peroxide Production. 用于高效过氧化氢生产的工程非晶/结晶Ni/NiO电催化剂。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-23 DOI: 10.1021/acsnano.5c13941

Rong-Yue Wang,Jia-Peng Zhong,Yu-Qiong Li,De-Xuan Li,Jia-Zhou Meng,Keng-Bo Ding,Chuan-Hao Li,Zhao-Qing Liu

{"title":"Engineering Amorphous/Crystalline Ni/NiO Electrocatalysts for Highly Efficient Hydrogen Peroxide Production.","authors":"Rong-Yue Wang,Jia-Peng Zhong,Yu-Qiong Li,De-Xuan Li,Jia-Zhou Meng,Keng-Bo Ding,Chuan-Hao Li,Zhao-Qing Liu","doi":"10.1021/acsnano.5c13941","DOIUrl":"https://doi.org/10.1021/acsnano.5c13941","url":null,"abstract":"Enhanced O2 adsorption and favorable oxygen-intermediate desorption are essential for efficient electrochemical hydrogen peroxide production (EHPP) via the two-electron oxygen reduction reaction (2e- ORR). Here, we report an amorphous/crystalline Ni-NiO electrocatalyst synthesized via a partial reduction strategy. By engineering the amorphous/crystalline interfacial strain through varying the reduction time, the optimized Ni/NiO catalyst achieves a hydrogen peroxide selectivity of 91.78% with a Faradaic efficiency of 97.47%. It maintains a high H2O2 yield of 949.5 mM/g-1cat h-1 across three electrode systems, outperforming most Ni-based benchmarks. Density functional theory calculations and in situ characterizations reveal that strain at unsaturated Ni sites promotes electron redistribution and Ni-O bond lengthening, thereby shifting the d-p band center difference to favor O2 adsorption while weakening *OOH binding. The enhanced O2 adsorption and accelerated *OOH desorption direct the ORR pathway toward the two-electron route for H2O2 generation. Furthermore, the in situ generated H2O2 effectively degrades organic pollutants, indicating its practical utility in water remediation. This work presents the strain engineering approach in amorphous/crystalline Ni/NiO heterostructures for high-performance EHPP and selective two-electron ORR.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Multi-Enzymatic Manganese-Carbon Dots Alleviate Sepsis-Associated Lung Injury via the Gut-Lung Axis. 口服多酶锰碳点通过肠-肺轴减轻败血症相关肺损伤。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-23 DOI: 10.1021/acsnano.5c10625

Lei Peng,Honghao Song,Huijing Shi,Lixue Wu,Yuqing Ma,Xiaoyi Fan,Min Wu,Liwei Duan,Zhenjie Li,Hongbin Yuan

{"title":"Oral Multi-Enzymatic Manganese-Carbon Dots Alleviate Sepsis-Associated Lung Injury via the Gut-Lung Axis.","authors":"Lei Peng,Honghao Song,Huijing Shi,Lixue Wu,Yuqing Ma,Xiaoyi Fan,Min Wu,Liwei Duan,Zhenjie Li,Hongbin Yuan","doi":"10.1021/acsnano.5c10625","DOIUrl":"https://doi.org/10.1021/acsnano.5c10625","url":null,"abstract":"Sepsis-induced pulmonary injury represents a life-threatening global health challenge due to poorly defined pathological mechanisms. The gut-lung axis has been proven to be widely involved in sepsis-induced lung injury, yet effective interventions targeting gut microbiota homeostasis remain unknown. Single-cell sequencing revealed increased alveolar apoptosis and impaired macrophage efferocytosis during sepsis pathogenesis. Thus, we designed oral manganese-doped carbon dots (Mn-CDs) to alleviate septic lung injury by remodeling gut microbiota homeostasis and targeting the gut-lung axis. Biochemical characterization demonstrated Mn-CDs possess multienzyme mimetic activities (SOD-, CAT-, POD-, GPx-like) and potent ROS scavenging capacity. In murine sepsis models, Mn-CDs significantly improved systemic indices and were associated with macrophage anti-inflammatory states with enhanced efferocytosis, as evidenced by transcriptomic profiling. Integrated metagenomic/metabolomic analyses identified Mn-CDs-mediated enrichment of g_Clostridium and g_Bacteroides, concomitant with elevated indole-3-propionic acid (IPA) production. Subsequent in vitro studies demonstrate that IPA likely binds primarily to the aryl hydrocarbon receptor (AHR), promoting both efferocytosis and anti-inflammatory polarization in macrophages, thereby mitigating septic lung injury. Notably, the fecal microbiota transplantation (FMT) from Mn-CDs-treated mice not only alleviated systemic symptoms but also effectively promoted efferocytic polarization of pulmonary macrophages in septic mice. Depletion of the gut microbiota resulted in a significant loss of the protective efficacy of Mn-CDs in a murine model of septic lung injury. Collectively, the gut-lung axis mediated by microbiota-derived IPA and macrophage efferocytosis contributes to the remediation of septic lung injury, highlighting the potential of Mn-CDs in microbiome-directed critical care.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"28 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proton-Resistant Quantum Dots by Ligands. 配体抗质子量子点。

IF 16 1区材料科学

ACS Nano Pub Date : 2025-10-22 DOI: 10.1021/acsnano.5c14377

Xia Zong, Meixin Liu, Xinran Xu, Fei Ding, Ling-Ling Yang, Wei Zhao, Haohao Fu, An-An Liu, Dai-Wen Pang

{"title":"Proton-Resistant Quantum Dots by Ligands.","authors":"Xia Zong, Meixin Liu, Xinran Xu, Fei Ding, Ling-Ling Yang, Wei Zhao, Haohao Fu, An-An Liu, Dai-Wen Pang","doi":"10.1021/acsnano.5c14377","DOIUrl":"https://doi.org/10.1021/acsnano.5c14377","url":null,"abstract":"Quantum dots (QDs) are widely recognized for their exceptional optical and electronic properties, rendering them valuable for diverse applications. However, the surface structure significantly influences their photoluminescence performance, particularly under acidic conditions, where protons can induce QD aggregation and fluorescence quenching. Herein, we propose a strategy relying solely on elaborate ligand engineering to construct proton-resistant QDs, eliminating the need for multilayer bulky coatings. Proton-resistant Ag2Se QDs have been achieved by a synergistic proton defense mechanism: electrostatic shielding and proton trapping. Specifically, introducing surface ligands with groups that become highly positively charged upon protonation (e.g., amino groups) and employing solvents with low dielectric constants (e.g., ethylene glycol) enhances electrostatic shielding. Furthermore, incorporating abundant hydrogen-bond donors/acceptors into the ligand structure promotes the formation of hydrogen-bonding networks that trap penetrating protons. This hierarchical proton defense, realized purely via precisely designed ligands, enables modified GSH-capped Ag2Se QDs to retain stable fluorescence at proton concentrations up to 0.8 mol/L, exhibiting a four-orders-of-magnitude enhancement in proton tolerance compared to conventional mercaptopropionic acid-capped QDs. This work provides a universal paradigm for designing proton-resistant QDs and advances nanomaterial engineering for harsh environments.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":16.0,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revealing and Engineering Assembly Pathways of 3D DNA Origami Crystals. 三维DNA折纸晶体的揭示和工程组装途径。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-22 DOI: 10.1021/acsnano.5c09008

Aaron Noam Michelson,Jason S Kahn,Daniel McKeen,Brian Minevich,Daniel C Redeker,Oleg Gang

{"title":"Revealing and Engineering Assembly Pathways of 3D DNA Origami Crystals.","authors":"Aaron Noam Michelson,Jason S Kahn,Daniel McKeen,Brian Minevich,Daniel C Redeker,Oleg Gang","doi":"10.1021/acsnano.5c09008","DOIUrl":"https://doi.org/10.1021/acsnano.5c09008","url":null,"abstract":"Recent developments in nanomaterial self-assembly demonstrate the capability to create tailored nanostructures by engineering both the binding coordination and specificity of interactions between material subunits. DNA origami frames allow for the design and fabrication of a broad variety of ordered 3D nanoscale architectures through self-assembly, facilitated by frame-to-frame bonds with designable strength and specificity. While the bond design is critical to lattice formation, the assembly process itself is often dependent on a thermal pathway. Highly ordered nanoscale frameworks, assembled from DNA frames, are predominantly crystallized through thermal annealing pathways that typically follow a \"slow\" cooling approach, with experiments on the time scale of days yielding DNA origami crystals in the range of 1-10 μm. This extended assembly time scale hinders the study of crystal formation pathways, necessitating a deeper understanding of factors governing successful annealing. Lack of insight into time scale also presents a practical limitation for material fabrication. Here, we investigate key factors affecting lattice assembly pathways and demonstrate that precise engineering of assembly conditions greatly reduces assembly times by up to nearly 2 orders of magnitude. We evaluate the nucleation and growth of crystals via optical and electron microscopy, and small-angle X-ray scattering techniques, mapping the time-temperature-transformation of superlattices from the melt through single-crystal optical tracking. The results show that origami frame assembly can be described by classical nucleation and growth theory, which can, in turn, be used to prescribe the growth of the crystals. Lastly, these findings are applied to demonstrate thermal pathway-dependent assembly, forming distinct assemblies based on different thermal annealing profiles.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"116 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the Potential of Cobalt-Free Lithium-Ion Cathodes via Lithium-Rich Disorder Domains. 通过富锂无序域释放无钴锂离子阴极的潜力。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-22 DOI: 10.1021/acsnano.5c09233

Hao Liu,Hang Li,Weibo Hua,Bixian Ying,Karin Kleiner,Jing Lin,Hang Xu,Bijian Deng,Deniz Wong,Thomas Bergfeldt,Stefan Mangold,Peter Nagel,Stefan Schuppler,Michael Merz,Volodymyr Baran,Wei Xiang,Yongjian Li,Ning Li,Michael Knapp,Helmut Ehrenberg,Sylvio Indris

{"title":"Unlocking the Potential of Cobalt-Free Lithium-Ion Cathodes via Lithium-Rich Disorder Domains.","authors":"Hao Liu,Hang Li,Weibo Hua,Bixian Ying,Karin Kleiner,Jing Lin,Hang Xu,Bijian Deng,Deniz Wong,Thomas Bergfeldt,Stefan Mangold,Peter Nagel,Stefan Schuppler,Michael Merz,Volodymyr Baran,Wei Xiang,Yongjian Li,Ning Li,Michael Knapp,Helmut Ehrenberg,Sylvio Indris","doi":"10.1021/acsnano.5c09233","DOIUrl":"https://doi.org/10.1021/acsnano.5c09233","url":null,"abstract":"High-voltage, low-nickel, cobalt-free layered oxides are promising candidates for high-energy-density lithium-ion batteries. However, their practical application is hindered by intrinsic cation disorder and structural degradation at high voltages, leading to a poor electrochemical performance. Here, we report a slightly lithium-enriched, cobalt-free layered oxide, Li1.05Ni0.43Mn0.52O2, featuring lithium-rich disorder domains achieved through chemical composition optimization. Advanced structural characterization demonstrates that nickel ions not only reside within the TM layers but also occupy the Li layers, acting as pinned ions. Theoretical calculations indicate that this in-plane and out-of-plane disorder enables reversible oxygen redox activity without oxygen release at high voltages. Moreover, this local structural framework preserves integrity even after extended cycling, ensuring chemical and structural stability during battery operation. Consequently, the cathode delivers an impressive discharge capacity of 202.2 mAh g-1 at C/10 and exceptional cycling stability, retaining 96.3% of its capacity after 200 cycles at C/3 within a voltage range of 2.5-4.55 V. Our findings provide valuable insights into the design of high-energy-density, cobalt-free layered cathodes.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"116 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust Silicon-Based Anode with High Energy Density upon Dual Welding Encapsulation. 双焊封装坚固的高能量密度硅基阳极。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-22 DOI: 10.1021/acsnano.5c13278

Wenhui Lai,Jong Hak Lee,Zhen Yuan Yeo,Yue Yuan,Yuqing Liu,Lu Shi,Yanhui Pu,Yong Kang Ong,Carlos Maria Alava Limpo,Yifan Rao,Ting Xiong,Mario Lanza,N Duane Loh,Barbaros Özyilmaz

{"title":"Robust Silicon-Based Anode with High Energy Density upon Dual Welding Encapsulation.","authors":"Wenhui Lai,Jong Hak Lee,Zhen Yuan Yeo,Yue Yuan,Yuqing Liu,Lu Shi,Yanhui Pu,Yong Kang Ong,Carlos Maria Alava Limpo,Yifan Rao,Ting Xiong,Mario Lanza,N Duane Loh,Barbaros Özyilmaz","doi":"10.1021/acsnano.5c13278","DOIUrl":"https://doi.org/10.1021/acsnano.5c13278","url":null,"abstract":"Silicon has long been considered one of the most promising anode materials for high-performance lithium-ion batteries due to its high theoretical capacity. However, a significant challenge that restricts its practical application is the persistent issue of weak interfacial contact in the silicon anode, which leads to structural instability during lithiation/delithiation processes due to large volume expansion. In this work, we develop a dual welding encapsulation strategy by constructing Si-C chemical bonding between the silicon and conductive covering shells and establishing C-C interlayer bonding connections among the covering shells. By directly examining the interface of silicon-based composites, we identify the types of compounds and hybrid orbital structures from their spatial distribution using machine-learning-enhanced transmission electron microscopy analysis techniques. This dual welding mechanism not only enhances the mechanical strength of the protective carbon shell but also ensures sustained electrical connection between the core and shell through the Si-C bonds. The robust heterogeneous structure effectively mitigates interfacial instability within the silicon anode, suppressing volume expansion below 12% after 300 cycles. Thus, the full-cell with the composite anode and LiNi0.8Co0.1Mn0.1O2 cathode performs a high energy density of 576 Wh kg-1 and stable cycling, inspiring the construction of commercial silicon batteries.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"29 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Self-Guiding Nanomotors Boost Active Immunotherapy. 仿生自导向纳米马达促进主动免疫治疗。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-22 DOI: 10.1021/acsnano.5c12737

Yicheng Ye,Hong Wang,Jiamiao Jiang,Xinmeng Cao,Jia Sun,Yuejun Jiang,Lu Liu,Weichang Huang,Hao Tian,Yang Yang,Fei Peng,Lihong Wen,Yingfeng Tu

{"title":"Biomimetic Self-Guiding Nanomotors Boost Active Immunotherapy.","authors":"Yicheng Ye,Hong Wang,Jiamiao Jiang,Xinmeng Cao,Jia Sun,Yuejun Jiang,Lu Liu,Weichang Huang,Hao Tian,Yang Yang,Fei Peng,Lihong Wen,Yingfeng Tu","doi":"10.1021/acsnano.5c12737","DOIUrl":"https://doi.org/10.1021/acsnano.5c12737","url":null,"abstract":"Efficient and precise delivery of chemotherapeutic drugs with deep tumor penetration is critically significant for tumor therapy. Unfortunately, the therapeutic efficacy of traditional passive nanomedicines is still limited by insufficient biological barrier penetration and inadequate release of damage-associated molecular patterns (DAMPs). Herein, a biomimetic Janus HZ-AD nanomotor system with biosignal sensing and energy conversion capabilities is first demonstrated. l-Arginine is incorporated into the hollow and urchin-like Au nanoparticles, while ZIF8 is asymmetrically decorated on one side, incorporating DOX loading. The developed nanomotors are capable of self-navigating to the tumor site, leveraging the chemotactic behavior of arginine to autonomously steer to higher concentrations of hydrogen peroxide, thereby enhancing the deep tumor penetration based on active motion actuated by NIR irradiation. Meanwhile, the active nanomotors also facilitate cellular uptake with the subsequent release of DOX and a considerable amount of Zn2+, further inducing pyroptosis and increasing the immunogenicity of tumor cells, thereby activating the immune response and inhibiting the tumor growth, recurrence, and metastasis. By adopting a spatially and temporally regulated trimodality therapy strategy of chemotactic targeting, motion-induced deep penetration, and photochemoimmunotherapy, the developed nanomotors address the existing challenges in tumor therapy and allow for possible therapeutic advancements.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"353 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating Amyloid Pathology-Neural Hyperexcitability Crosstalk for Alzheimer's Disease Therapy. 调节淀粉样蛋白病理-神经高兴奋性串扰治疗阿尔茨海默病。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-22 DOI: 10.1021/acsnano.5c08317

Ying Wang,Jinfu Li,Ding Zhang,Yinyao Feng,Mengni Zhou,Chang Zhou,Dijia Wang,Gaolin Qiu,Wei Dai,Zhilai Yang,Yunjiao Zhang,Li Zhang,Xuesheng Liu,Jiqian Zhang

{"title":"Modulating Amyloid Pathology-Neural Hyperexcitability Crosstalk for Alzheimer's Disease Therapy.","authors":"Ying Wang,Jinfu Li,Ding Zhang,Yinyao Feng,Mengni Zhou,Chang Zhou,Dijia Wang,Gaolin Qiu,Wei Dai,Zhilai Yang,Yunjiao Zhang,Li Zhang,Xuesheng Liu,Jiqian Zhang","doi":"10.1021/acsnano.5c08317","DOIUrl":"https://doi.org/10.1021/acsnano.5c08317","url":null,"abstract":"Current therapies for Alzheimer's disease (AD) primarily target amyloid-β (Aβ) pathology using monoclonal antibodies, yet their limited efficacy partly results from unintended exacerbation of neural hyperexcitability. This highlights a critical but under-appreciated link between Aβ clearance and neuronal network dysfunction. Here, we designed R@AClipo, a nanotherapeutic platform that codelivers the TREM2 agonist peptide COG1410 and the glutamate modulator riluzole via Angiopep-2-modified liposomes capable of crossing the blood-brain barrier. In AD model mice, R@AClipo upregulated TREM2 expression and enhanced microglial-mediated Aβ clearance. Concurrently, it reduced glutamate accumulation and mitigated neuronal hyperexcitability, as measured by in vivo fiber photometry. Notably, TREM2-driven Aβ clearance alone modestly reduced hyperexcitability, independent of riluzole, contrasting with the excitatory effects frequently associated with antibody-based Aβ therapies. This combinatorial strategy improved cognitive performance and restored neural activity patterns without observable toxicity. Together, these findings support a physiologically compatible strategy that targets the pathological crosstalk between Aβ accumulation and neural hyperexcitability, offering a promising avenue for AD intervention.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"26 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking Neuroprotection: Simultaneous Suppression of Mitochondrial Energetic Collapse and Oxidative-Inflammatory Vortex for Ischemia-Reperfusion Brain Injury. 解锁神经保护：缺血再灌注脑损伤时线粒体能量崩溃和氧化-炎症漩涡的同时抑制。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-22 DOI: 10.1021/acsnano.5c15229

Shuya Wang,Xiaojing Shi,Tingli Xiong,Wenxuan Zheng,Ruishi Li,Weimin Qi,Min Liu,Lin Dai,Min Zhou,Wei Dai,Qiong Huang,Xiaoying Wang,Kelong Ai

{"title":"Unlocking Neuroprotection: Simultaneous Suppression of Mitochondrial Energetic Collapse and Oxidative-Inflammatory Vortex for Ischemia-Reperfusion Brain Injury.","authors":"Shuya Wang,Xiaojing Shi,Tingli Xiong,Wenxuan Zheng,Ruishi Li,Weimin Qi,Min Liu,Lin Dai,Min Zhou,Wei Dai,Qiong Huang,Xiaoying Wang,Kelong Ai","doi":"10.1021/acsnano.5c15229","DOIUrl":"https://doi.org/10.1021/acsnano.5c15229","url":null,"abstract":"The strategy of restoring mitochondrial function by modulating mitochondrial membrane potential (MMP) through uncoupling protein 2 (UCP2) offers significant therapeutic potential against cerebral ischemia-reperfusion injury (CIRI). However, traditional strategies ignored elevation of mitochondrial reactive oxygen species (mtROS) resulting from UCP2 inhibition, resulting in poor therapeutic effects. Here, we reported a multifunctional SGB nanomedicine formed by pioneering the prepolymerization of the UCP2 inhibitor genipin and glycine and a cerebral infarction targeting peptide via a metastable imine bond. After intravenous injection, SGB was highly targeted to affected brain tissue and reached neuronal mitochondria. SGB could not only restore MMP by cleaving the metastable imine bond to release genipin to inhibit overexpressed UCP2, but also simultaneously eliminated excessive mtROS. Compared with traditional UCP2 inhibition, SGB could not only significantly improve the bioavailability of genipin and reduce systemic side effects, but also effectively protected neuronal mitochondria, reduced endoplasmic reticulum stress and inhibited the inflammatory storm of microglia, ultimately significantly reduced neuronal apoptosis. Correspondingly, SGB nearly reversed CIRI with a low 5 mg/kg dose. This innovative approach redefines the role of UCP2 inhibition and provides a framework for the treatment of CIRI by maintaining mitochondrial function.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"3 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Macroscopic Quantum Tunneling to Quantum Computing: The 2025 Nobel Prize in Physics. 从宏观量子隧穿到量子计算：2025年诺贝尔物理学奖。

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-10-22 DOI: 10.1021/acsnano.5c17715

Prineha Narang,Mark C Hersam

引用次数: 0