ACS Nano最新文献

{"title":"Erlotinib Engineering Programs Tumor Targeting in an Atomically Precise Au8 Cluster","authors":"Shuai-Bo Wang,&nbsp;Xue-Yu Ge,&nbsp;Wen-Hao Xu,&nbsp;Xueli Zhao,&nbsp;Yanjuan Sang,&nbsp;Zhao-Yang Wang,&nbsp;Shuang-Quan Zang","doi":"10.1021/acsnano.6c15906","DOIUrl":"10.1021/acsnano.6c15906","url":null,"abstract":"<p>Atomically precise metal clusters hold great promisefor cancertheranostics, yet current strategies for introducing tumor-targetingfunctionality often compromise their structural precision. Herein,an erlotinib (Er)-functionalized gold cluster, Au₈-Er,is constructed through ligand engineering for targeted non-small-celllung cancer (NSCLC) theranostics. The Er ligands endow Au₈-Er with high affinity toward the epidermal growth factor receptor(EGFR), enabling selective tumor targeting and preferential accumulationat lung tumor sites. Under the glutathione-rich tumor microenvironment,Au₈-Er releases Er to achieve chemotherapy. Simultaneously,the cluster exhibits strong X-ray attenuation and oxygen-sensitivephosphorescence, allowing it to function as both an X-ray scintillatorand a photosensitizer for efficient X-ray-induced photodynamic therapy(X-PDT) under low-dose irradiation. Moreover, its X-ray-excited luminescenceenables high-contrast imaging. The synergistic integration of targetedchemotherapy, X-PDT, and imaging within a structurally precise nanoplatformresults in enhanced therapeutic efficacy against NSCLC. This workhighlights ligand engineering as an effective strategy for impartingbiological functionality to atomically precise metal clusters andadvances their application in precision cancer theranostics.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 41","pages":"28008–28018"},"PeriodicalIF":17.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Amplifying Cascade Enzymatic Nanoplatform Orchestrating Metabolic Reprogramming and Oxidative Stress for Antitumor Therapy","authors":"Yusheng Chen,&nbsp;Qiang Liu,&nbsp;Mengluan Gao,&nbsp;Lingjian Zhang,&nbsp;Hengke Liu,&nbsp;Shan Lei,&nbsp;Jing Lin,&nbsp;Rujia Zou,&nbsp;Peng Huang","doi":"10.1021/acsnano.6c09137","DOIUrl":"10.1021/acsnano.6c09137","url":null,"abstract":"<p>Nanocatalytictumor therapy utilizes nanomaterials to catalyzechemical reactions, producing cytotoxic species that kill tumor cells;however, the metabolic heterogeneity of tumor cells significantlycompromises therapeutic efficacy. Herein, we developed a self-amplifyingcascade enzymatic nanoplatform (ReS₂@GOx) for nanocatalytictumor therapy by orchestrating metabolic reprogramming and oxidativestress. This nanoplatform integrates rhenium disulfide (ReS₂) nanozyme possessing trimodal enzyme-mimetic activities (catalase(CAT)-like, nicotinamide adenine dinucleotide (NADH) oxidase (NOX)-like,and glutathione oxidase (GSHOx)-like activities) with glucose oxidase(GOx), enabling three interlocked therapeutic actions: (1) externalenergy-independent singlet oxygen (¹O₂) generationthrough ReS₂-mediated hydrogen peroxide (H₂O₂) conversion involving a superoxide anion (•O₂^-) intermediate; (2) attenuation of metabolic circuitsthrough NADH oxidation and glutathione depletion; and (3) a cycliccascade reaction driven by GOx-mediated glucose oxidation and H₂O₂ production, coupled with CAT-mediated H₂O₂-to-O₂ conversion, sustaining glucoseoxidation and NADH consumption. Mechanistic studies reveal a noncanonical ¹O₂ generation pathway involving electron shuttle-mediated•O₂^– conversion, establishinga redox loop fueled by endogenous substrates (e.g., glucose, NADH).The coordinated enzymatic triad achieves dual tumor suppression, includingblocking adenosine triphosphate (ATP) production by inhibiting glycolysis/oxidativephosphorylation (OXPHOS) and inducing lipid peroxidation. This workdemonstrates a nanocatalytic tumor therapy strategy that orchestratestumor metabolism to potentiate oxidative lethality, highlighting thetherapeutic potential of metabolic regulation for tumor treatment.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 41","pages":"27748–27761"},"PeriodicalIF":17.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano Delivery Systems for In Vivo CRISPR/Cas-Based Gene Therapy: From Vectors to Clinical Outcomes","authors":"Ruhan Chen,&nbsp;Haimei Zhou,&nbsp;Qinjie Wu,&nbsp;Changyang Gong","doi":"10.1021/acsnano.6c12154","DOIUrl":"10.1021/acsnano.6c12154","url":null,"abstract":"<p>Asa powerful gene-editing tool, the clustered regularly interspacedshort palindromic repeats (CRISPR)/CRISPR-associated (Cas) systemfeatures simple construction, precise targeting, and higher editingefficiency, bringing prospects of radical cures for numerous criticalillnesses at the genomic level. To date, ex vivo CRISPR/Cas-basedgene therapies represented by Casgevy have achieved significant clinicaladvances. Nevertheless, cumbersome operational workflows and prohibitivetreatment costs severely hinder their widespread clinical accessibility.In contrast, in vivo CRISPR/Cas-based gene therapies stand out withconvenient administration procedures and reduced overall costs, endowingthem with enormous translational potential. Although it holds greatpromise, the clinical translation of in vivo CRISPR/Cas-based genetherapies remains hampered by a number of factors. Among those multipleobstacles restricting the clinical translation of in vivo CRISPR/Cas-basedgene therapies, delivery systems constitute the core bottleneck dominatingin vivo editing efficiency and therapeutic potency. Centered on deliveryplatforms for in vivo CRISPR/Cas-based gene therapies, this reviewsystematically summarizes prevailing in vivo CRISPR/Cas nano deliverysystems, recapitulates relevant preclinical and clinical outcomes,discusses translational hurdles, and prospects the evolution of next-generationdelivery systems, aiming to facilitate further development of in vivoCRISPR/Cas-based gene therapies.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 41","pages":"27559–27640"},"PeriodicalIF":17.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Terminal Reconfigurable Silver Nanowire Network for Associative-Learning-Like Response and Path Optimization","authors":"Jiawen Qiu,Kun Wang,Wei Huang,Hao Su,Yongai Zhang,Xiongtu Zhou,Tailiang Guo,Chaoxing Wu","doi":"10.1021/acsnano.6c18064","DOIUrl":"https://doi.org/10.1021/acsnano.6c18064","url":null,"abstract":"Emulating associative-learning-like responses and hardware-state-guided path optimization using reconfigurable physical networks offers a promising route toward adaptive neuromorphic hardware. Herein, a multiterminal reconfigurable Ag nanowire network is presented. This network exhibits a honeybee-inspired associative learning response and provides experimentally measured conductance states for ant colony pathfinding simulations. By employing a multielectrode array to deliver synchronized odor-like and nectar-like electrical stimuli, the network dynamically reconfigures its conductance pathways in a training-dependent manner. Following training, the postsynaptic current increases by 2 orders of magnitude after the first learning cycle and reaches a sustained suprathreshold level after three cycles, demonstrating that the device can simulate long-term memory consolidation. Software simulations further show that the experimentally measured Ag NW learning states can modulate a handwritten digit recognition model through a hardware-derived memory gate, enabling conditioned-stimulus-only recognition to improve progressively during associative learning. Furthermore, specific stimulation protocols reconfigure the conductance pathways of the Ag NW network, and the resulting hardware conductance states are used as weighting factors in ant-colony-inspired software simulations. With these hardware-derived weights, the simulated optimal path length is reduced from 1643.54 units to 1415.18 units, corresponding to an improvement of approximately 14% in path-search efficiency. This study highlights the potential of integrating reconfigurable physical networks with bioinspired algorithms, offering a hardware-software codesign platform for future adaptive neuromorphic systems.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"26 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encoding Light in Electronic Noise","authors":"Arpan Ghosh,&nbsp;Seema Rani,&nbsp;Anshul Rasyotra,&nbsp;Samriddha Ray,&nbsp;Karthik G. Krishnan,&nbsp;Md Sajjad Alam,&nbsp;Anirban Chowdhury,&nbsp;Kaushik Ghosh,&nbsp;Saptarshi Das","doi":"10.1021/acsnano.6c08996","DOIUrl":"10.1021/acsnano.6c08996","url":null,"abstract":"<p>Optical sensing in semiconductors is traditionally governedbyphotoconductive, photovoltaic, and photogating effects, in which opticalinputs are encoded as continuous variations in average current. Here,we demonstrate a fundamentally distinct paradigm in which light isencoded in stochastic transport dynamics rather than steady-stateconductance. Using a monolayer MoS₂ field-effect transistorwith an aggressively scaled gate stack (∼1.3 nm equivalentoxide thickness), we access a regime where interfacial defect statesdominate transport and form gate-tunable potential wells. At low temperature,carrier emission from these states is suppressed, stabilizing trappedconfigurations in the dark, whereas optical excitation selectivelyactivates emission, giving rise to large-amplitude (“giant”)random telegraph noise. This enables independent control of captureand emission processes through electrostatic gating and illumination,respectively, creating a direct mapping between optical input andstochastic observables such as switching rates, dwell times, and stateoccupancies. Interestingly, optical detection is achieved throughthe statistics of rare emission events, enabling sensitivity to ultralowillumination levels (∼50 fW). Spectral dependence further revealsphoton energy–dependent emission kinetics, confirming the roleof photon-assisted detrapping. These results show a light-inducednonequilibrium transport regime in which defect-mediated fluctuations,conventionally treated as noise, act as a functional signal and providea stochastic sensing framework for ultralow-light detection in nanoscaleelectronic systems.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 41","pages":"27738–27747"},"PeriodicalIF":17.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12.1% Record-Efficiency 986 nm Quantum-Cutting Quasi-2D Perovskite Light-Emitting Diodes for Large-Area Dual-Mode Applications","authors":"Yuqi Wang,&nbsp;Donglei Zhou,&nbsp;Renhuan Song,&nbsp;DePeng He,&nbsp;Shangwei Zhou,&nbsp;Wei Li,&nbsp;Ruixin Song,&nbsp;Enhui Wang,&nbsp;Jin Liang,&nbsp;Xue Bai,&nbsp;Hongwei Song","doi":"10.1021/acsnano.6c08495","DOIUrl":"10.1021/acsnano.6c08495","url":null,"abstract":"<p>Ytterbium-ion (Yb³⁺)-doped quasi-2D layeredmetal halideperovskites (quasi-2D LMHPs) stand out as a transformative platformfor near-infrared (NIR) emissions beyond 950 nm, holding great promisefor revolutionizing next-generation photonic systems. Herein, we reporta synergistic engineering strategy to simultaneously regulate phasedistribution in the emissive layer and carrier transport in the hole-transportlayer, enabling record-performance NIR perovskite light-emitting diodes(PeLEDs) emitting at 986 nm. The incorporation of fluorinated aromaticspacers (p-F-PEA⁺) and partial formamidinium (FA⁺) substitution strengthens organic–inorganic interactions,affording well-controlled phase distribution and highly efficientexciton-to-Yb³⁺ energy transfer. Meanwhile, zwitterionickanamycin is introduced to neutralize the intrinsic acidity of PEDOT:PSSvia distinct chemical interactions, leading to balanced carrier injectionand suppressed nonradiative recombination. Benefiting from this dual-layermodulation, the optimized Yb³⁺-doped (PEA_1.8p-F-PEA_0.2)(Cs_1.6FA_0.4)Pb₃Br₁₀ PeLEDs exhibit a record peak NIR external quantumefficiency (EQE) of 12.1% at 986 nm and an outstanding operationalhalf-life (T₅₀) of 1823 min. More critically, we breakthe scalability bottleneck of NIR PeLEDs with 300 mm² large-areadevices delivering a state-of-the-art EQE of over 7.5%. We pioneera visible/NIR dual-mode display and imaging platform via patternedPeLEDs, integrating explicit visible identification and covert NIRhigh-security anticounterfeiting. This work broadens the applicationprospects of NIR PeLEDs in high-security anticounterfeiting, nondestructiveimaging, and smart photonic systems.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 41","pages":"27716–27727"},"PeriodicalIF":17.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermally Tunable Fading Memory Enabled by Opto-Ionic-Electronic Coupling in AgInP2S6-Gated Two-Dimensional Field-Effect Transistors","authors":"Dipanjan Sen,&nbsp;Anirban Chowdhury,&nbsp;Anshul Rasyotra,&nbsp;Lei Ding,&nbsp;Rui Gusmao,&nbsp;Subir Ghosh,&nbsp;Arpan Ghosh,&nbsp;Joan M. Redwing,&nbsp;Divya Somvanshi,&nbsp;Yang Yang,&nbsp;Zdenek Sofer,&nbsp;Saptarshi Das","doi":"10.1021/acsnano.5c21149","DOIUrl":"10.1021/acsnano.5c21149","url":null,"abstract":"<p>In conventional field-effect transistors (FETs), thegate dielectricprimarily provides electrostatic control of the channel and is engineeredto remain chemically and electronically inert to ensure stable operation.Emerging studies, however, suggest that functional dielectrics integratedwith two-dimensional (2D) semiconductors can introduce additionalphysical mechanisms that influence device behavior. Here, we investigateAgInP₂S₆ (AIPS), a high-κ van der Waalsthiophosphate, as a functional top-gate dielectric in MoS₂ field-effect transistors. The AIPS/MoS₂ heterointerfaceexhibits coupled opto-ionic-electronic interactions, where defect-mediatedsub-bandgap photoactivity and photon-assisted Ag⁺ ion migrationindependently occur within the dielectric yet collectively modulatethe channel conductance. Optical excitation redistributes charge withinthe dielectric, gradually reconfiguring the ionic landscape and alteringthe interfacial electrostatic potential. The resulting conductanceexhibits strong temperature dependence. At low temperatures (∼0°C), reduced phonon activity suppresses Ag⁺ mobility,leading to persistent photoconductivity. At elevated temperatures(∼80 °C), thermally activated ion hopping acceleratesrelaxation of the stored state. This temperature-dependent retentionbehavior enables a thermally tunable fading memory response, wherethe persistence of the optically induced conductance state can becontrolled through ionic dynamics. These results highlight how opto-ioniccoupling at 2D/dielectric interfaces can introduce stimulus-responsivefunctionality in transistor architectures, providing a platform fordevices that combine sensing and memory behavior within the gate stack.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 41","pages":"27665–27677"},"PeriodicalIF":17.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling Phase Separation in Polymer-Derived Silicon Carbonitride Ceramics through Extended Machine Learning Molecular Dynamics","authors":"Fabien Mortier,&nbsp;Sylvian Cadars,&nbsp;Olivier Masson,&nbsp;Mauro Boero,&nbsp;Guido Ori,&nbsp;Yun Wang,&nbsp;Samuel Bernard,&nbsp;Assil Bouzid","doi":"10.1021/acsnano.6c11958","DOIUrl":"10.1021/acsnano.6c11958","url":null,"abstract":"<p>Polymer-derived ceramics combine the thermal stabilityof ceramicswith the versatile properties of carbon domains, but modeling theiratomic-scale evolution during processing remains elusive because ofthe limitations of traditional computational methods. To address thisissue, here, we develop and apply a machine learning interatomic potentialfor hydrogen-containing silicon carbonitride-based (SiCNH) ceramics,trained on a diversified database of over 9000 configurations─includingamorphous models, high-temperature states, surfaces, and crystal structurepredictions─to capture the full complexity of these materials.This potential enables large-scale molecular dynamics simulationsof 8000-atom systems, revealing the atomic-scale evolution of thepolymer-derived ceramic during thermal treatment. A key result ofthis work is the occurrence of a phase separation, where carbon domainsprogressively nucleate from the amorphous SiCN matrix during thermalprocessing, forming distinct graphene-like sheets while preservingthe integrity of the ceramic network. The resulting models reproducethe experimental atomic pair distribution functions, supporting ourapproach and providing microscopic explanations for the material combinationof the ceramic and graphitic properties. In this process, defective5- and/or 7-member carbon rings mediate the transformation to stable6-member aromatic structures. These findings provide atomic-scaleinformation about the thermal stability and structural transformationpathways of polymer-derived ceramics and demonstrate the applicabilityof the methodology to complex amorphous systems at experimentallyrelevant scales.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 41","pages":"27874–27889"},"PeriodicalIF":17.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Deformable Ceramics: The Origin, Evolution, and Prospectives of Electrospun Ceramic Nanofiber Materials","authors":"Ruida Ding,&nbsp;Cheng Liu,&nbsp;Ruixiang Xu,&nbsp;Jong Won Baek,&nbsp;Minhyun Kim,&nbsp;Siyu Qiang,&nbsp;Il-Doo Kim,&nbsp;Jianyong Yu","doi":"10.1021/acsnano.6c08357","DOIUrl":"10.1021/acsnano.6c08357","url":null,"abstract":"<p>Ceramics are renowned for their exceptional high-temperaturestabilityand resistance to corrosion and oxidation. However, their inherentbrittleness and susceptibility to fracture significantly limit theirpractical use in harsh and mechanically demanding environments. Ceramicnanofibers (ceramic NFs) combine the intrinsic thermal and chemicalrobustness of ceramics with the structural advantages afforded byfibrous architectures. This combination unlocks substantial potentialfor a wide range of advanced applications. This review criticallyexamines the origin and evolution of electrospun ceramic NF materials.Key aspects include the underlying principles and preparation methodologies,structural diversity and classification of ceramic NFs, mechanicalcharacterization techniques, and the mechanisms governing strengthenhancement at both individual fiber and network levels. Recent advancesin leveraging these materials for energy regulation, material separationand conversion, and biomedical functions are critically analyzed.Furthermore, the challenges impeding the scalable manufacturing ofelectrospun ceramic NFs are discussed, along with proposed strategiesto address these limitations. Finally, the review outlines futureperspectives for enhancing performance and broadening the applicationscope of electrospun ceramic NFs.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 41","pages":"27527–27558"},"PeriodicalIF":17.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boron-Doped Nanomaterials/Copper Synergistic Photocatalytic C(sp3)–N Cross-Coupling","authors":"Fuyang Yue,&nbsp;Fei Yuan,&nbsp;Hongjian Song,&nbsp;Yuxiu Liu,&nbsp;Qingmin Wang","doi":"10.1021/acsnano.6c05569","DOIUrl":"10.1021/acsnano.6c05569","url":null,"abstract":"<p>Heterogeneous photocatalysis hasemerged as a sustainable paradigm for C–N bond construction;however, its application has been predominantly confined to C(sp²)–N couplings, typically relying on the modulationof nickel catalytic cycles. The efficient construction of C(sp³)–N bonds remains a formidable challenge due to thehigh energy barriers of alkyl-metal oxidative addition and the inabilityof traditional semiconductors to orchestrate radical kinetics. Herein,we report a robust and versatile C(sp³)–N cross-couplingsystem enabled by a boron-doped nanomaterial (BDN) in synergy witha copper catalyst. The strategic incorporation of boron atoms─characterizedby their vacant <em>p</em>-orbitals and Lewis acidity─intothe heptazine framework transcends the role of simple light-harvesting,creating chemically active sites that effectively direct charge carrierseparation and dictate alkyl radical generation. Extensive characterization,including quasi-in situ XPS and EPR, confirms that boron centers actas efficient electron acceptors, facilitating spatially directed chargetransfer. This synergistic BDN/Cu platform accommodates an exceptionallybroad substrate scope, including various N-nucleophiles (amides, sulfonamides,heterocycles) and diverse radical precursors (alkanes, alkyl boronicacids, and alkyl iodides). Furthermore, the protocol’s syntheticutility is underscored by its successful extension to C(sp²)–N arylation and its seamless transition to a continuous-flowsystem, achieving gram-scale production. This work provides a generalstrategy for molecular-level engineering of heterogeneous catalyststo unlock challenging bond-forming transformations.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 41","pages":"27678–27691"},"PeriodicalIF":17.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}