ACS Nano最新文献

{"title":"Graph–Property Relationships for Complex Chiral Nanodendrimers","authors":"Vera Kuznetsova, Alain Kadar, Anita Gaenko, Engin Er, Tao Ma, Kody G. Whisnant, Jessica Ma, Bing Ni, Natasha Mehta, Ji-Young Kim, Yurii K. Gun’ko, Nicholas A. Kotov","doi":"10.1021/acsnano.4c12964","DOIUrl":"https://doi.org/10.1021/acsnano.4c12964","url":null,"abstract":"Organic, polymeric, and inorganic nanomaterials with radially diverging dendritic segments are known for their optical, physical, chemical, and biological properties inaccessible for traditional spheroidal particles. However, a methodology to quantitatively link their complex architecture to measurable properties is difficult due to the characteristically large degree of disorder, which is essential for observed property sets. Here, we address this conceptual problem using dendrimer-shaped gold particles with distinct stochastic branching and intense chiroptical activity using graph theory (GT). Unlike typical molecular or nanostructured dendrites, gold nanodendrimers are two-dimensional, with branches radially spreading within one plane. They are also chiral, with mirror asymmetry propagating through multiple scales. We demonstrate that their complex architecture is quantitatively described by image-informed GT models accounting for both regular and disordered structural components of the nanodendrimers. Furthermore, descriptors integrating topological and geometrical characteristics of particle graphs provide physics-based analytical relations to the nontrivial dependence of optical asymmetry <i>g</i>-factor on the particle structure. The simplicity of the GT models capable of capturing the complexity of the particle organization and related light–matter interactions enables the rapid design of scalable nanostructures with multiple functions.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"12 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manganese Ions Chelated Tumosomes as Autologous Cancer Nanovaccines for Effective Suppression of Postsurgical Tumor Relapse","authors":"Minming Chen, Yu Hao, Sisi Ling, Hongchao Yang, Quguang Li, Yumin Wu, Chunjie Wang, Yuchun Xu, Yifan Yan, Juxin Gao, Chunyan Li, Liangzhu Feng, Zhuang Liu","doi":"10.1021/acsnano.4c10146","DOIUrl":"https://doi.org/10.1021/acsnano.4c10146","url":null,"abstract":"Autologous cancer vaccines represent a promising strategy to effectively suppress postoperative tumor relapse by eliciting tumor-specific immune responses that highly rely on the efficient internalization and lymph node-targeting delivery of vaccines. Herein, we report an autologous nanovaccine obtained by sequentially incorporating tumor plasma membrane proteins into liposomes, termed tumosomes, and chelating it with metallo-agonist of manganese ions. The yielded Mn-tumosomes with a positively charged surface exhibited significantly enhanced internalization by dendritic cells and enhanced lymph node targeting capacity, the latter of which is indicated by the near-infrared II fluorescence of silver sulfide nanoprobes labeled on their lipid bilayers. As a result, vaccination with Mn-tumosomes elicited potent tumor-specific CD8+ T cells to suppress the growth of challenged allogeneic tumors more effectively than vaccination <i>via</i> bolus injection of plain tumosomes and commercial immune agonists. Furthermore, with the excised tumor mass as the source of whole tumor cell antigens, the as-prepared autologous Mn-tumosomes effectively suppressed the growth of both residual tumor masses and spontaneously formed metastatic tumors, particularly in combination with anti-PD-1 immunotherapy. This work highlights a metal coordination based strategy to fabricate personalized whole-tumor cell nanovaccines with superior lymph node targeting and cellular uptake efficacy for the immunotherapeutic suppression of postoperative tumor relapse.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"15 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voltage-Gated 90° Switching of Bulk Perpendicular Magnetic Anisotropy in Ferrimagnets","authors":"Zhengyu Xiao, Ruiwen Xie, Fernando Maccari, Philipp Klaßen, Benedikt Eggert, Di Wang, Yuting Dai, Raquel Lizárraga, Johanna Lill, Tom Helbig, Heiko Wende, Kurt Kummer, Katharina Ollefs, Konstantin P Skokov, Hongbin Zhang, Zhiyong Quan, Xiaohong Xu, Robert Kruk, Horst Hahn, Oliver Gutfleisch, Xinglong Ye","doi":"10.1021/acsnano.4c11663","DOIUrl":"https://doi.org/10.1021/acsnano.4c11663","url":null,"abstract":"Unraveling the mechanism behind bulk perpendicular magnetic anisotropy (PMA) in amorphous rare earth-transition metal films has proven challenging. This is largely due to the inherent complexity of the amorphous structure and the entangled potential origins arising from microstructure and atomic structure factors. Here, we present an approach wherein the magneto-electric effect is harnessed to induce 90° switching of bulk PMA in Tb–Co films to in-plane directions by applying voltages of only −1.2 V. This manipulation is achieved by voltage-driven insertion of hydrogen atoms into interstitial sites between Tb and Co atoms, which serves as a perturbation to the local atomic structure. Using angle-dependent X-ray magnetic circular dichroism, we find that the anisotropy switching originates from the distortion of the crystal field around Tb, which reorients the alignment of Tb orbital moments. Initially aligned along Tb–Co bonding directions, the easy magnetization axis undergoes reorientation and switches by 90°, as substantiated by ab initio calculations. Our study not only concludes the atomic origin of Tb–Co atom bonding configuration in shaping bulk PMA but also establishes the groundwork for electrically programmable ferrimagnetic spintronics, such as controlling domain wall motion and programming artificial spin textures.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"13 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired Superwettable Surfaces and Materials for Liquid Motion Control","authors":"Huijie Wei, Lingmei Zhu, Maolin Zhou, Tiance Zhang, Chang Gao, Qiang Luo, Boyang Tian, Jianhua Wang, Yongping Hou, Yongmei Zheng","doi":"10.1021/acsnano.4c15866","DOIUrl":"https://doi.org/10.1021/acsnano.4c15866","url":null,"abstract":"Directional fluid dynamics has garnered increasing attention because of its extensive applications in diverse fields including water harvesting, anti-icing, and microfluidic manipulation. Natural organisms have evolved a myriad of surfaces with specialized functions that manipulate liquids by virtue of their surface structure and chemical composition. These surfaces provide an extremely rich source of inspiration for controlled fluid transfer. The study of the fundamentals of what happens between droplets and functional surfaces and the close interactions is essential for the development of technologies and solutions in different fields. Exploring the inherent workings of droplet manipulation on natural biosurfaces can inspire the design and development of superwettable materials. This review deepens the understanding of directed fluid dynamics by summarizing interface fluid dynamics theory and mechanisms. It presents the fundamental principles of directed fluid dynamics on typical natural biological surfaces. Additionally, it elucidates the fluid dynamics behavior and applications of a diverse set of smart functional surfaces inspired by natural organisms. Simultaneously, it shares its view on superwetting interface liquid dynamics challenges and opportunities, pushing for next-generation biomimetic superwettable materials.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"39 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Nanosheet Immunoswitches Reprogramming Innate Macrophages for Immunotherapy of Colorectal Cancer and Sepsis","authors":"Yoonhee So, DaBin Yim, Hyo Keun Kim, Sin Lee, Hyunji Lee, Yejoo Yu, Chanhee Choi, Yujin Choi, Hongwon Kim, Chul-Su Yang, Jong-Ho Kim","doi":"10.1021/acsnano.4c08828","DOIUrl":"https://doi.org/10.1021/acsnano.4c08828","url":null,"abstract":"Macrophages are involved in the immunopathogenesis of cancer and inflammatory diseases and are a primary target for immunotherapy to reprogram the M1 and M2 phenotypes in tumor and inflammatory microenvironments. Herein, functional nanosheet immunoswitches that can bidirectionally polarize macrophages in tumor and inflammatory microenvironments are designed for effective immunotherapy of colorectal cancer and sepsis. WSe₂ nanosheets are functionalized with palmitic acid to obtain an M1 immunoswitch (PA-WSe₂) that promotes the polarization of macrophages toward the M1 phenotype in the tumor microenvironment by activating the STAT1 signaling pathway. WS₂ nanosheets bearing linoleic acid are synthesized as an M2 immunoswitch (LA-WS₂) that effectively polarizes macrophages to the M2 phenotype in the septic microenvironment by activating the STAT3 signaling pathway. The PA-WSe₂ M1 immunoswitch upregulates the secretion of pro-inflammatory cytokines and reactive oxygen and nitrogen species (ROS and RNS) via M1 polarization, leading to the effective immunotherapy for colorectal cancer <i>in vivo</i>. In contrast, the LA-WS₂ M2 immunoswitch induces the elevated production of anti-inflammatory cytokines and scavenging of ROS and RNS through M2 polarization, resulting in superior immunotherapy for severe sepsis in mice. These nanosheet immunoswitches can provide a route to immunotherapy for various cancers and inflammatory diseases.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"36 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electric Field-Tunable Superconductivity with Competing Orders in Twisted Bilayer Graphene near the Magic Angle","authors":"Ranit Dutta, Ayan Ghosh, Shinjan Mandal, Kenji Watanabe, Takashi Taniguchi, H. R. Krishnamurthy, Sumilan Banerjee, Manish Jain, Anindya Das","doi":"10.1021/acsnano.4c12770","DOIUrl":"https://doi.org/10.1021/acsnano.4c12770","url":null,"abstract":"Superconductivity (SC) in twisted bilayer graphene (tBLG) has been explored by varying carrier concentrations, twist angles, and screening strength, with the aim of uncovering its origin and possible connections to strong electronic correlations in narrow bands and various resulting broken symmetries. However, the link between the tBLG band structure and the onset of SC and other orders largely remains unclear. In this study, we address this crucial gap by examining in situ band structure tuning of a near magic-angle (θ ≈ 0.95°) tBLG device with a displacement field (<i>D</i>) and reveal competition between SC and other broken symmetries. At zero <i>D</i>, the device exhibits superconducting signatures without the resistance peak at half-filling, a characteristic signature with a strong electronic correlation. As <i>D</i> increases, the SC is suppressed, accompanied by the appearance of a resistance peak at half-filling. Hall density measurements reveal that at zero <i>D</i>, SC arises around the van Hove singularity (vHs) from an isospin or spin-valley unpolarized band. At higher <i>D</i>, the suppression of SC coincides with broken isospin symmetry near half-filling with lifted degeneracy (<i>g</i>_d ∼ 2). Additionally, as the SC phase becomes weaker with <i>D</i>, vHs shifts to higher fillings, highlighting the modification of the underlying band structure with the applied electric field. These findings, with recent theoretical study on SC in tBLG, highlight the competition, rather than being connected concomitantly, between SC and other orders promoted by broken symmetries.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"22 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unequal {110} Facets: The Potential Role of Intraparticle Heterogeneity and Facet Termination in Photoelectrochemical Activity of Single BiVO4 Particles","authors":"Avishek Banik, Hiroaki Maekawa, Javier Fajardo, Brian Zutter, Francis M. Alcorn, Suhas Kumar, Kenta Watanabe, Akihiko Kudo, Nien-Hui Ge, A. Alec Talin, Justin B. Sambur","doi":"10.1021/acsnano.4c15460","DOIUrl":"https://doi.org/10.1021/acsnano.4c15460","url":null,"abstract":"BiVO₄ photoanodes are promising for solar water splitting, with photogenerated electrons and holes preferentially reacting at top {010} and lateral {110} facets, respectively. However, the mechanisms driving this facet-dependent reactivity remain unclear. Here, we investigate facet-dependent photocurrent and material heterogeneity using correlative scanning photoelectrochemical microscopy (SPCM), electron beam induced current (EBIC) mapping, and mid-IR scattering scanning near-field optical microscopy (s-SNOM). SPCM measurements of 62 BiVO₄ particles confirmed higher photocurrents at lateral {110} facets compared to top {010} facets, but unexpectedly revealed variations in photocurrent among lateral facets within the same particle. Variations in lateral facet surface termination could explain the intraparticle-level reactivity heterogeneity, consistent with theoretical predictions. Nano-FTIR spectroscopy and Raman microspectroscopy indicated significant materials chemistry heterogeneity within individual particles and facets that could be attributed to variations in lattice vibration distortions that enhance the overlap between Bi 6s and O 2p orbitals. The increased orbital overlap is significant as it potentially increases hole mobility in the valence band and potentially explains the lateral facet-dependent charge separation efficiency observed in photocurrent maps. Facet-dependent electrical and EBIC measurements showed no space charge regions at interfacet junctions or metal-BiVO₄ contacts under vacuum, suggesting that photogenerated holes beneath top {010} facets are unlikely to transport to lateral {110} facets to drive water/sulfite oxidation. These findings indicate the potential influence of distinct bulk properties and surface termination chemistries across different particles and facets, highlighting the importance of carefully controlling defects and surface chemistry during sample growth to optimize photocatalytic performance.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"133 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the Role of PEGylation on the Lipid Nanoparticle-Mediated mRNA Delivery to the Liver","authors":"Menghua Gao, Jiafeng Zhong, Xinxin Liu, Yanjun Zhao, Dingcheng Zhu, Xiaohuo Shi, Xuehan Xu, Qin Zhou, Wenjing Xuan, Yue Zhang, Yaofeng Zhou, Jianjun Cheng","doi":"10.1021/acsnano.4c09399","DOIUrl":"https://doi.org/10.1021/acsnano.4c09399","url":null,"abstract":"Organ- and cell-specific delivery of mRNA via modular lipid nanoparticles (LNPs) is promising in treating various diseases, but targeted cargo delivery is still very challenging. Most previous work focuses on screening ionizable and helper lipids to address the above issues. Here, we report the multifacial role of PEGylated lipids in manipulating LNP-mediated delivery of mRNA to the liver. We employed the typical excipients in LNP products, including DLin-MC3-DMA, DPSC, and cholesterol. Five types of PEGylated lipids were selected, and their molar ratio was fixed at 1.5% with a constant PEG molecular weight of 2000 Da. The architecture of steric lipids dramatically affected the in vitro gene transfection, in vivo blood clearance, liver deposition, and targeting of specific cells, all of which were closely linked to the de-PEGylation rate. The fast de-PEGylation resulted in short blood circulation and high accumulation in the liver. However, the ultrafast de-PEGylation enabled the deposition of more LNPs in Kupffer cells other than hepatocytes. Surprisingly, simply changing the terminal groups of PEGylated lipids from methoxyl to carboxyl or amine could dramatically increase the liver delivery of LNPs, which might be associated with the accelerated de-PEGylation rate and enhanced LNP–cell interaction. The current work highlights the importance of manipulating steric lipids in promoting mRNA delivery, offering an alternative approach for formulating and optimizing mRNA LNPs.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fully Inter-restricted Assembly of Aggregation-Induced Emission Luminogens and Polymers Enables Ultra-bright Nanoparticles for Sensitive Point-of-Care Diagnosis","authors":"Xirui Chen, Qi Liu, Jiangjiang Zhang, Linjie Tan, Jiangao Li, Miao-La Ke, Ben Zhong Tang, Ying Li","doi":"10.1021/acsnano.4c15372","DOIUrl":"https://doi.org/10.1021/acsnano.4c15372","url":null,"abstract":"Fluorescent lateral flow immunoassay (LFIA) is recognized as a leading quantitative point-of-care (POC) platform for precise clinical diagnostics. However, conventional fluorescent nanoprobes are hampered by low quantum yield (QY), which constrain the sensitivity of fluorescent LFIA. Herein, we employed a butterfly aggregation-induced emission luminogen (AIEgen) and developed the fully inter-restricted assembly with a polyphenyl polymer poly(maleicanhydride-styrene) (PMPS) to create highly fluorescent homogeneous nanoparticles (ho-AIENPs) with QY over 91%. Compared to conventional fluorescent nanoparticles with a core–shell heterostructure (he-AIENPs), ho-AIENPs demonstrate a homogeneous structure with AIEgens uniformly dispersed in the PMPS matrix nanoparticles. The robust and broad intermolecular interaction (e.g., π–π interactions) between PMPS and AIEgens effectively restricts the molecular motion of AIEgens, producing a 30% increase in the QY of ho-AIENPs than he-AIENPs. Ho-AIENPs exhibit a 5-fold and 80-fold improved sensitivity compared to traditional he-AIENP-based fluorescent LFIAs and AuNP-based colorimetric LFIAs. Owing to the excellent optical properties of ho-AIENPs, we developed ho-AIENP-based multiplex LFIAs, which can simultaneously detect lung cancer biomarkers with exceptionally high sensitivity. In contrast to the conventional core–shell assembly and physical encapsulation strategies, the fully inter-restricted assembly strategy is promising, versatile, and efficient in enhancing the polymer matrix-derived fluorescent particles and sensitizing the immunoassays.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"122 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene Quantum Dots Attenuate TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis","authors":"Na Young Park, Yunseok Heo, Ji Won Yang, Je Min Yoo, Hye Ji Jang, Ju Hee Jo, Su Jeong Park, Yuxi Lin, Joonhyeok Choi, Hyeonjin Jeon, Sun Joo Cha, Gaeun Bae, Donghoon Kim, Juhee Kim, Wade Zeno, Jong Bo Park, Noriyoshi Isozumi, Tomohide Saio, Seung Hyun Kim, Hojae Lee, Byung Hee Hong, Minyeop Nahm, Young-Ho Lee, Young Bin Hong","doi":"10.1021/acsnano.4c15283","DOIUrl":"https://doi.org/10.1021/acsnano.4c15283","url":null,"abstract":"Aberrant phase separation- and stress granule (SG)-mediated cytosolic aggregation of TDP-43 in motor neurons is the hallmark of amyotrophic lateral sclerosis (ALS). In this study, we found that graphene quantum dots (GQDs) potentially modulate TDP-43 aggregation during SG dynamics and phase separation. The intrinsically disordered region in the C-terminus of TDP-43 exhibited amyloid fibril formation; however, GQDs inhibited the formation of amyloid fibrils through direct intermolecular interactions with TDP-43. These effects were accompanied by attenuation of the ALS phenotype in animal models. Additionally, GQDs delayed the onset and survival of TDP-43 transgenic mouse models by enhancing motor neuron survival, reducing glial activation, and reducing the cytosolic aggregation of TDP-43 in motor neurons. In this research, we demonstrated the efficacy of GQDs on the SG-mediated aggregation of TDP-43 and the binding property of GQDs with TDP-43. Additionally, we demonstrated the clinical feasibility of GQDs using several animal models and other types of ALS caused by FUS and C9orf72. Therefore, GQDs could offer a new therapeutic approach for proteinopathy-associated ALS.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"61 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}