ACS Nano最新文献

{"title":"Calibration-Free Measurement of the Phonon Temperature around a Single Emitter","authors":"Francis Granger, Edith Bellet-Amalric, Kuntheak Kheng, Gilles Nogues, David Ferrand, Joël Cibert","doi":"10.1021/acsnano.5c03631","DOIUrl":"https://doi.org/10.1021/acsnano.5c03631","url":null,"abstract":"The emission properties of a localized solid-state emitter are strongly influenced by its environment. The coupling to acoustic phonons impacts the coherence of the emitter and its temperature dependence, and also results in the apparition of phonon sidebands besides the sharp zero-phonon line. Here, we present a method for measuring the absolute temperature of a localized emitter by directly plotting the ratio of the Stokes and anti-Stokes components of the phonon sideband as a function of the shift from the zero-phonon line. This approach requires no calibration and knowledge of the system, making it applicable to a wide range of emitters and materials. We validate the method using a CdSe quantum dot in a ZnSe nanowire. We thus show that the quantum dot is significantly heated under nonresonant excitation when increasing the incident power at low temperature which is ascribed to the drop in thermal conductivity at these temperatures.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"6 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strong In-plane Magnetic Anisotropy in Semiconducting Monolayer CoCl2","authors":"Samuel Kerschbaumer, Sebastien Elie Hadjadj, Andrea Aguirre-Baños, Danilo Longo, Andrés Pinar Solé, Oleksandr Stetsovych, Adriana Elizabet Candia, Paula Angulo-Portugal, David Caldevilla, Fadi Choueikani, Martina Corso, David Serrate, Jorge Lobo-Checa, Pavel Jelínek, Maxim Ilyn, Celia Rogero","doi":"10.1021/acsnano.5c02175","DOIUrl":"https://doi.org/10.1021/acsnano.5c02175","url":null,"abstract":"Transition-metal dihalides (TMDH) are emerging as a highly promising class of 2D magnetic materials due to their simplicity, stability, and compatibility with nanofabrication techniques. In this work, we explore the structural, electronic, and magnetic properties of monolayer CoCl₂ grown epitaxially on Au(111) using a multitechnique approach. Our results reveal that epitaxial CoCl₂ exhibits ferromagnetic order below 24 K with strong in-plane magnetic anisotropy, setting it apart from other TMDH materials. Additionally, we identify in-gap states arising from the CoCl₂–Au(111) interface, which provide insights into its electronic behavior. These findings position CoCl₂ as a versatile 2D material for spintronic applications and nanoscale devices, bridging the gap between fundamental research and real-world technological solutions.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"6 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring Abundance and Activity of Electrochemically Inactive Protein in a Single Cell by an Atomically Precise Metal Cluster-Based Electrochemical Sensor","authors":"Ying Han, Cuicui Qiu, Fuping Gao, Kai Cao, Peng Cao, Yuhua Tang, Yumeng Duan, Haolin Zou, Hui Yuan, Xueyun Gao, Liang Gao","doi":"10.1021/acsnano.5c02859","DOIUrl":"https://doi.org/10.1021/acsnano.5c02859","url":null,"abstract":"The analysis of tumor metastasis-associated proteins is of vital importance for monitoring tumor evolution and evaluating therapeutic outcomes of protein-targeted drugs. However, electrochemically analyzing both the abundance and activity of these electrochemically inactive proteins in single living cells remains an unresolved challenge. Here, we develop an electrochemical sensor composed of a nanoelectrode functionalized by atomically precise metal clusters with excellent electrocatalytic activity. It enables highly selective detection of electrochemically inactive proteins associated with tumor metastasis. Via this sensor, we demonstrate the relation between cathepsin B abundance and metastatic features of tumor cells. The inherent heterogeneous protein expression among individual cells is confirmed by a quantitative manner. Additionally, this methodology allows for the assessment of cathepsin B activity in response to the antimetastatic drug exposure at a single-cell level. It deepens our understanding of cathepsin B’s role in tumor metastasis and provides potential for precise evaluation of cathepsin B-targeted drugs.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"27 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confinement-Regulated Lamellar Interphase with Enhanced Dielectric Environments for Lithium Metal Batteries","authors":"Ruixin Lv, Chong Luo, Ke Wang, Wangming Tang, Bingran Liu, Yi Liu, Yang Li, Li Li, Feng Wu, Renjie Chen","doi":"10.1021/acsnano.5c04491","DOIUrl":"https://doi.org/10.1021/acsnano.5c04491","url":null,"abstract":"The natural solid electrolyte interphase (SEI) typically consists of complex ingredients and disordered structures, posing significant challenges in achieving rapid Li⁺ desolvation and uniform Li⁺ deposition, which leads to uncontrolled electrolyte decomposition and lithium dendrite growth. This study designs a lamellar sieving interphase with enhanced dielectric environments, achieved through confinement-regulated polymer chain conformation, effectively decoupling the Li⁺ desolvation and deposition processes. The lamellar interphase selectively sieves solvent molecules, promoting Li⁺ desolvation and enhancing the dissociation of lithium salts. The nanofluidic channel within the confined lamella promotes ion transfer, ensuring uniform ion distribution and improving mechanical stability. Lithium metal anodes with this lamellar interphase exhibit exceptional stability during stripping/plating cycling, maintaining stable performance for over 2000 h at 2 mA cm^–2. Furthermore, LiFePO₄||Li and NCM811||Li batteries assembled with the lamellar interphase demonstrate a stable reversible capacity and cycling performance. This study presents a lamellar interphase design, offering tunable confinement and regulation mechanisms to decouple the Li⁺ desolvation and deposition processes with stable cycling performance in lithium metal batteries.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"45 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain-Insensitive, Air-Stable Stretchable Carbon Nanotube-Based Synaptic Transistors Array via Direct Microfabrication for Neuromorphic Computing","authors":"Dingzhou Cui, Zhiyuan Zhao, Fugu Tian, Wenbo Chen, Mingrui Chen, Max Zhou, Xiaoqi Wu, Jingxin Zhang, Chongwu Zhou","doi":"10.1021/acsnano.4c16874","DOIUrl":"https://doi.org/10.1021/acsnano.4c16874","url":null,"abstract":"Stretchable synaptic transistors show great promise in mimicking brain activities in soft robotics and skin electronics applications. However, the fabrication of such device arrays on elastic substrates with high stability, throughput, and yield remains challenging. Here, we have developed an approach to fabricate stretchable synaptic transistors directly on elastic substrates, in which carbon nanotubes and SU-8 are used as channel and dielectric, respectively. This method employs a fully photolithography-based microfabrication process that operates at relatively low temperatures. The devices exhibit an average on–off ratio of 2 × 10⁶ and show minimal degradation when stretched up to 40%. Single-pulse, paired-pulse, and repetitive-pulse responses are also demonstrated, showing their ability to work as artificial synapses. The devices exhibit a high linearity of ≤1 with 100 distinct conductance states in long-term plasticity and a dynamic range of 15. Furthermore, we conducted a handwritten digit recognition simulation, achieving a learning accuracy of over 90%. We believe our work can serve as a guide for developing high-performance stretchable synaptic devices for various applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"70 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic Liposomes for G-Protein-Coupled Receptor 120 Exo/Endogenous Coactivation to Reprogram Lipid Metabolism in Obesity-Associated Osteoarthritis","authors":"Ming-Yang Li, Li-Min Wu, Ming-Jie Xu, Mei-Ling Shen, Jie-Hao Chen, Qin-Jie Wu, Rui Wang, Yi Zeng, Yuan-Gang Wu, Hai-Bo Si, Xiao-Ting Chen, Hang Li, Chang-Yang Gong, Hui-Qi Xie, Bin Shen","doi":"10.1021/acsnano.5c02515","DOIUrl":"https://doi.org/10.1021/acsnano.5c02515","url":null,"abstract":"Osteoarthritis (OA) associated with obesity is increasingly recognized as a distinct phenotype, driven by lipid metabolic imbalance and related inflammation. A particularly troublesome issue is that even after successfully correcting obesity, OA progression and lipid metabolic imbalance persist within the joint microenvironment, suggesting local lipid metabolism regulation as a potential treatment option. G-protein-coupled receptor 120 (GPR120), a primary receptor for long-chain fatty acids (including docosahexaenoic acid, DHA), has recently been found to play a pivotal role in regulating lipid homeostasis and suppressing inflammation. Here, we present ChD-FL/sgGPR, enabling dual endogenous–exogenous GPR120 activation. ChD-FL/sgGPR is a chondrocyte-biomimetic, fluorinated phenylboronic acid (FPBA)-modified ionizable liposome that codelivers DHA and a CRISPRa system comprising GPR120-specific sgRNA (single guide RNA) and dCas9-VPR mRNA (dead Cas9 fused to VP64-p65-Rta activator domain). Specifically, FPBA modification of liposomes enhances lysosomal escape and nuclear entry of RNA, while coextrusion with chondrocyte membranes facilitates cartilage-targeted delivery. In the coculture system of adipocytes and OA chondrocytes, ChD-FL/sgGPR significantly boosts chondrocytes GPR120 expression, facilitates lipid clearance via PPARγ signaling, and diminishes inflammatory mediators. In obese rat OA models, intra-articular injection of ChD-FL/sgGPR prolongs local retention, inhibits cartilage catabolism, and mitigates subchondral bone deterioration, collectively decelerating OA progression. By integrating CRISPR-mediated gene upregulation with DHA-induced receptor stimulation, this platform rebalances lipid metabolism in OA cartilage, offering a promising, mechanism-driven therapy for obesity-associated OA.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"8 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anisotropic Crystallographic Engineering of α-MoO3","authors":"Qiyao Liu, Zhipeng Li, Xuezhi Ma, Qiushi Liu, Fengxia Wei, Siew Lang Teo, Ruihuan Duan, Adrianzka Mayreswara Dewa Rachmawisista, Yueqian Zhang, Coryl Jing Jun Lee, Jie Deng, Aihong Huang, Ping Luo, Hui Kim Hui, Sherry Lee Koon Yap, Meng Zhao, Rong Ji, Yu Luo, Zheng Liu, Qian Wang","doi":"10.1021/acsnano.5c07199","DOIUrl":"https://doi.org/10.1021/acsnano.5c07199","url":null,"abstract":"The α-phase molybdenum trioxide (α-MoO₃), a biaxial hyperbolic van der Waals (vdW) crystal, supports highly confined and anisotropic phonon polaritons (PhPs), positioning it as a superior platform for mid-infrared light manipulation. The performance of PhP-based devices critically depends on the properties of α-MoO₃ flakes, including their thickness, roughness, and pattern geometry. However, conventional patterning techniques, such as ion beam milling and plasma etching, often introduce doping artifacts and surface damage, resulting in high PhP losses. In this work, we develop a hot-water-based technique for the crystallographic engineering of α-MoO₃, leveraging its anisotropic etching properties for surface polishing and nanopatterning. This method exploits the notably higher etching rate along intralayer directions ([100], [001]) compared to the interlayer direction ([010]). Consequently, a 24% enhancement in PhP lifetime was observed in RIE-treated α-MoO₃ flakes after hot water polishing, with no measurable change in material thickness. To further validate this technology, we fabricated various two-dimensional PhP manipulation devices using standard nanopatterning and thinning processes, followed by chemical-free hot water anisotropic crystallographic etching. This approach enabled the creation of nanoresonators, lenses, nanocavities, and unidirectional emitters with sharp edges precisely aligned along the crystallographic planes. Our crystallographic engineering approach unlocks precise control of surface waves at the nanoscale, facilitating the development of photonic devices for cutting-edge nanophotonic and nanoscale sensing applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"1 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose-Fueled Gated Nanomotors: Enhancing In Vivo Anticancer Efficacy via Deep Drug Penetration into Tumors","authors":"Andrea Escudero, Francisco J. Hicke, Elena Lucena-Sánchez, Sandra Pradana-López, Juan José Esteve-Moreno, Víctor Sanz-Álvarez, Iris Garrido-Cano, Sandra Torres-Ruiz, Juan Miguel Cejalvo, Alba García-Fernández, Paula Díez, Ramón Martínez-Máñez","doi":"10.1021/acsnano.5c03799","DOIUrl":"https://doi.org/10.1021/acsnano.5c03799","url":null,"abstract":"Bioinspired nano/micromotors with drug delivery capabilities are emerging tools with the promising potential to treat numerous diseases. However, some major challenges must be overcome before reaching real biomedical applications. Above all, it is necessary to design engines that employ biocompatible and bioavailable fuels to induce efficient propulsion in biological environments. In addition, ideal nanomotors should also be capable of delivering the cargo on-command using selected stimuli. To tackle these challenges, we herein present the design and evaluation (both <i>in vitro</i> and <i>in vivo</i>) of a glucose-driven gated Janus nanomotor that performs on-demand anticancer drug delivery to treat solid tumors. The motor’s nanoarchitectonics is based on the anisotropic conjunction of catalytic platinum nanodendrites (PtNds) and a mesoporous silica nanoparticle (acting as a nanocontainer for anticancer drug doxorubicin) capped with enzyme glucose oxidase (GOx). Autonomous nanomotor movement is achieved thanks to two catalytic components, GOx and PtNds, in a hybrid cascade reaction: GOx transforms glucose to give H₂O₂ that is subsequently catalyzed by PtNds into H₂O and O₂. Besides, gatekeeper moieties (GOx) respond to the presence of intracellular proteases, which induces doxorubicin delivery. Biological experiments with the nanomotor are carried out in cancer cell cultures, three-dimensional (3D) tumor models (spheroids), <i>in vivo</i> and in patient-derived organoids (PDOs). A strong anticancer effect is found and attributed to the synergistic combination glucose-induced propulsion, controlled drug delivery, elimination of glucose (by GOx), ROS production (H₂O₂ generation by GOx) and hypoxia reduction (O₂ generated by PtNds). Taken together, this study advances the engineering of endogenously fueled nanomotors for <i>in vivo</i> operation and provides insights into the application of active particles in cancer therapy toward clinical application.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"2 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MXene-Based Cartilage-Adhesive Microspheres for Photothermal-Controlled Hydrophobic Drug Release and Mesenchymal Stem Cell Delivery in Osteoarthritis","authors":"Fan Chen, Wenzhe Wang, Hengxin Zhao, Zian Zhang, Nanyu Pang, Yijie Tang, Tian Wang, Chang Liu, Zhenchao Huang, Feiyu Mou, Chaoqun Yu, Haining Zhang","doi":"10.1021/acsnano.4c16918","DOIUrl":"https://doi.org/10.1021/acsnano.4c16918","url":null,"abstract":"Intra-articular drug injection is an effective treatment for osteoarthritis (OA). However, the rapid clearance of drugs from the joint cavity results in low drug utilization and suboptimal therapeutic outcomes. This study describes MXene-based cartilage-adhesive microspheres for photothermal-controlled hydrophobic drug release and bone marrow mesenchymal stem cell (BMSC) delivery. Nano cationic amylose (NCA) was obtained by modifying amylose with glycidyltrimethylammonium chloride (GTAC), and hydrophobic drug Kartogenin (KGN) was encapsulated in the hydrophobic helical cavity of NCA through ultrasonic treatment, resulting in nano cationic amylose@KGN complexes (NCA@KGN). HAMA/MXene-NCA@KGN (H/M-NCA@KGN) microspheres were prepared using a microfluidic device. These microspheres exhibited excellent biocompatibility, effectively adhered to the cartilage surface, and carried BMSCs. H/M-NCA@KGN microspheres demonstrated photothermal-controlled release of the hydrophobic drug KGN. Notably, KGN promoted the differentiation of BMSCs into chondrocytes, thereby improving the loss of extracellular matrix in joint cartilage. Additionally, appropriate thermal stimulation induced the expression of heat shock protein 70 (HSP70) in OA chondrocytes, providing a protective effect and delaying the progression of OA. H/M-NCA@KGN microspheres enable controlled hydrophobic drug release and stem cell delivery for potential OA treatment applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"4 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monolayer Short-Channel Transistors Defined by Nonmetallic van der Waals Contact","authors":"Xinjie Hou, Ruiqing Cheng, Yuchan Hu, Xiaolin Zhang, Lei Yin, Jian Jiang, Yao Wen, Ximeng Peng, Xunguo Gong, Dahua Ren, Jun He","doi":"10.1021/acsnano.5c01481","DOIUrl":"https://doi.org/10.1021/acsnano.5c01481","url":null,"abstract":"Two-dimensional (2D) semiconductors have excellent immunity to short-channel effects and are therefore promising for ultrascaled field-effect transistors. However, ultrascaled transistors necessitate simultaneous minimization of the channel length and contact resistance, which is a significant challenge for atomically thin 2D semiconductors. In this work, a facile angle evaporation technique is developed to fabricate ultrashort channel monolayer 2D transistors with nonmetallic van der Waals (vdW) contacts. By precisely controlling the evaporation angle and the thickness of the physical vapor deposition-grown nonmetallic PbTe, which owns ultrasharp edges due to its perfect and stable periodic crystal structure, the channel length of 2D transistors can be controlled reproducibly. Moreover, due to the nonmetallic contact properties of PbTe, there are negligible metal-induced gap states (MIGS) between PbTe and 2D semiconductors; thus, almost no additional Fermi-level pinning (FLP) at the heterostructure interface. The short-channel MoS₂ transistor with PbTe vdW contact exhibits superior performance, including excellent ohmic contacts, near-Boltzmann-limit subthreshold swing, high on/off current ratio (∼10⁹), and negligible drain-induced barrier lowering (∼82 mV V^–1). In addition, the device can also operate at a low voltage of 0.01 V with a desirable on/off ratio of ∼10⁸, providing a facile technique to fabricate 2D material-based low-power ultra-scaled transistors.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"9 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}