ACS Nano最新文献

{"title":"AI-Guided Hydrophobic Core Design of Robust Six-Helix Bundle Proteins.","authors":"Yinying Meng,Guojin Tang,Ruishi Wang,Bin Zheng,Yuanhao Liu,Hantian Zhang,Peng Zheng","doi":"10.1021/acsnano.5c13783","DOIUrl":"https://doi.org/10.1021/acsnano.5c13783","url":null,"abstract":"α-Helical domains are widespread and versatile, yet typically fail under low mechanical load because backbone hydrogen bonds unzip sequentially, limiting their use in force-bearing nanomaterials and molecular devices. We present an AI-guided strategy to design six-helix bundle proteins with densely packed hydrophobic cores that co-optimize mechanical and thermal stability. Backbones were generated with RFdiffusion, sequences designed with ProteinMPNN, and structures validated by AlphaFold2/ESMFold; steered and annealing molecular dynamics simulation identified designs with high predicted unfolding forces and heat resilience. Three selected constructs (HP149, HP206, HP347) expressed solubly and folded as predominantly α-helical by circular dichroism. AFM-based single-molecule force spectroscopy revealed unfolding forces approaching 100 pN, much higher than typical α-helical domains (∼20 pN). All three retained substantial helical content to ≥100 °C. Mutating buried hydrophobic residues (V17S, L104R in HP149) reduced unfolding forces, confirming core packing as an important determinant. These results establish hydrophobic-core design as a promising route to robust α-helical scaffolds.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"22 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spinterface Mechanism for the Chiral-Induced Spin Selectivity Effect: A Critical Perspective.","authors":"Subhajit Sarkar,Amos Sharoni,Oliver L A Monti,Yonatan Dubi","doi":"10.1021/acsnano.5c16086","DOIUrl":"https://doi.org/10.1021/acsnano.5c16086","url":null,"abstract":"The chirality-induced spin selectivity (CISS) effect, whereby chiral molecules preferentially transmit electrons of one spin orientation, remains one of the most intriguing and debated phenomena at the interface of spintronics, molecular electronics, and quantum materials. Despite extensive experimental observations across diverse platforms─including transport junctions, photoemission, and enantioselective chemistry─a comprehensive theoretical framework is still lacking. In this perspective, we critically examine the spinterface mechanism as a unifying explanation for the CISS effect. The spinterface model, which hypothesizes a feedback interaction between electron motion in chiral molecules and fluctuating surface magnetic moments, is shown to quantitatively reproduce experimental data across various systems and conditions. We contrast it with some existing theoretical models, highlighting key experimental features. Importantly, we also address open questions and criticisms of this model, including the nature of surface magnetism, the role of dissipation, and the applicability of the mechanism to nonhelical or electrode-free systems. By offering falsifiable predictions and reconciling theory with experimental raw data, this work aims to sharpen the dialogue surrounding the microscopic origin of CISS and stimulate further experimental and theoretical progress.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"71 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Above-Room-Temperature Ferromagnetism in Large-Scale Epitaxial Fe₃GaTe₂/Graphene van der Waals Heterostructures.","authors":"Tauqir Shinwari, Kacho Imtiyaz Ali Khan, Hua Lv, Atekelte Abebe Kassa, Frans Munnik, Simon Josephy, Achim Trampert, Victor Ukleev, Chen Luo, Florin Radu, Jens Herfort, Michael Hanke, Joao Marcelo Jordao Lopes","doi":"10.1021/acsnano.5c07732","DOIUrl":"https://doi.org/10.1021/acsnano.5c07732","url":null,"abstract":"<p><p>Fe₃GaTe₂ (FGaT), a two-dimensional (2D) layered ferromagnetic metal, exhibits a high Curie temperature (<i>T</i>_C) of ∼360 K along with strong perpendicular magnetic anisotropy (PMA), making it a promising material candidate for next-generation energy-efficient magnetic devices. However, the vast majority of studies on FGaT to date have been limited to millimeter-sized bulk crystals and exfoliated flakes, which are unsuitable for practical applications and integration into device processing. Also, its combination with other 2D materials to form van der Waals (vdW) heterostructures has only been achieved by flake stacking. Consequently, the controlled large-area growth of FGaT and related heterostructures remains largely unexplored. In this work, we demonstrate the high-quality, large-area growth of epitaxial FGaT thin films on single-crystalline graphene/SiC templates using molecular beam epitaxy. Structural characterization confirms the high crystalline quality of the continuous FGaT/graphene vdW heterostructures. Temperature-dependent magnetization and anomalous Hall measurements reveal robust PMA with an enhanced <i>T</i>_C well above room temperature, reaching up to 400 K. Furthermore, X-ray absorption and X-ray magnetic circular dichroism spectra provide insight into the spin and orbital magnetic moment contributions, further validating the high <i>T</i>_C and robust PMA. These findings are highly significant for the future development of high-performance spintronic devices based on 2D heterostructures, with potential applications in next-generation data storage, logic processing, and quantum technologies.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":16.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezo-Nanowired Stem Cells: Ultrasound-Powered Neuronal Commitment for Rapid Neural Circuit Reconstruction after Traumatic Brain Injury.","authors":"Keyi Li,Wenhan Wang,Wenjun Ma,Yiwei Li,Jiahao Zhang,Ailing Yin,Liang Wang,Boyan Li,Qingtong Wang,Gang Li,Hong Liu,Jichuan Qiu","doi":"10.1021/acsnano.5c08752","DOIUrl":"https://doi.org/10.1021/acsnano.5c08752","url":null,"abstract":"The inherently constrained regenerative capacity of neuronal tissue poses a major obstacle to repairing traumatic brain injury. While neural stem cell transplantation holds promise, its efficacy is constrained by slow and inefficient neuronal differentiation. Here, we engineered piezo-nanowired stem cells by anchoring piezoelectric barium titanate nanowires to neural stem cell membranes, enabling ultrasound-powered piezoelectrical stimulation to drive neuronal differentiation. The high-aspect-ratio barium titanate nanowires stably localize on cell membranes, enabling targeted electrical stimulation to membrane-bound receptors under ultrasound. In vitro, this approach accelerated neuronal differentiation by 5 days, increasing the mature neuron ratio from 14.0% to 30.7%, and enhancing synaptic network complexity. In a traumatic brain injury rat model, barium titanate nanowires combined with ultrasound promoted rapid neural stem cells differentiation into functional neurons, restoring motor and cognitive functions and reconstructing neural networks at the injury site. By integrating wireless piezoelectric stimulation with neural stem cell transplantation, this work provides a promising approach for precise neuromodulation in neurological regeneration.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"1 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nucleation-Mediated Aluminum Deposition/Stripping for Long-Life Molten Salt Aluminum Batteries.","authors":"Zhitong Xiao,Yongfeng Jia,Lujun Zhu,Chenxi Zheng,Wei Hao,Pengfei Zhang,Jiashen Meng,Mengxue He,Lei Ji,Jian Wang,Mohammadhosein Safari,Yakun Liu,Wei Wen,Quanquan Pang","doi":"10.1021/acsnano.5c10579","DOIUrl":"https://doi.org/10.1021/acsnano.5c10579","url":null,"abstract":"Molten salt aluminum batteries (MSABs) hold significant promise for grid-scale energy storage due to the low cost and high capacity of the aluminum anode. However, an aluminum dendrite stemming from nonuniform electrodeposition leads to safety and stability issues. Here, we describe a membrane electrode with predeposited aluminum metal featuring surface-mediated nucleation and growth behavior for operation in alkali chloroaluminate melt electrolytes. The introduction of TiN, as aluminophilic sites, facilitates the initial growth of aluminum on TiN by forming Al-N bonding, thereby enabling uniform aluminum nucleation and mediated growth along the TiN/C fiber, resulting in reversible and dendrite-free aluminum plating/stripping. The TiN/C@Al electrode enables symmetric cells to maintain stable cycling for over 850 h (10.0 mA cm-2; 5.0 mA h cm-2) and shows high rate performance at up to 30.0 mA cm-2. The Al-graphite cell using a TiN/C@Al anode demonstrates long-term stability over 7000 cycles at 2.0 A g-1 and enhanced rate capability with 72.2 mA h g-1 even at 5.0 A g-1. To validate practical scalability, we designed an Ah-level TiN/C@Al-based molten salt Al-graphite pouch cell. This approach offers a scalable pathway for overcoming the limitations of state-of-the-art anodes in MSABs, enabling high-performance and cost-effective energy storage solutions.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"25 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Atomic-Scale Control over Structural Modulations in Quasi-1D Chalcogenides for Colossal Optical Anisotropy.","authors":"Guodong Ren, Shantanu Singh, Gwan Yeong Jung, Wooseon Choi, Huandong Chen, Boyang Zhao, Kevin Ye, Andrew R Lupini, Miaofang Chi, Jordan A Hachtel, Young-Min Kim, Jayakanth Ravichandran, Rohan Mishra","doi":"10.1021/acsnano.5c07992","DOIUrl":"https://doi.org/10.1021/acsnano.5c07992","url":null,"abstract":"<p><p>Optically anisotropic materials are sought after for tailoring the polarization of light. Recently, colossal optical anisotropy (Δ<i>n</i> = 2.1) was reported in a quasi-one-dimensional chalcogenide, Sr_9/8TiS₃. Compared to SrTiS₃, the excess Sr in Sr_9/8TiS₃ leads to periodic structural modulations and introduces additional electrons, which undergo charge ordering on select Ti atoms to form a highly polarizable cloud oriented along the <i>c</i>-axis, hence resulting in the colossal optical anisotropy. Here, further enhancement of the colossal optical anisotropy to Δ<i>n</i> = 2.5 in Sr_8/7TiS₃ is reported through control over the periodicity of the atomic-scale modulations. The role of structural modulations in tuning the optical properties in a series of Sr_<i>x</i>TiS₃ compounds with <i>x</i> = [1, 9/8, 8/7, 6/5, 5/4, 4/3, 3/2] is investigated using density-functional-theory (DFT) calculations. The structural modulations arise from various stacking sequences of face-sharing TiS₆ octahedra and twist-distorted trigonal prisms and are found to be thermodynamically stable for 1 < <i>x</i> < 1.5. As <i>x</i> increases, an indirect-to-direct band gap transition is predicted for <i>x</i> ≥ 8/7 along with an increased occupancy of Ti-<i>d</i>_<i>z</i>² states. Together, these two factors result in a theoretically predicted maximum birefringence of Δ<i>n</i> = 2.5 for Sr_8/7TiS₃. Single crystals of Sr_8/7TiS₃ were grown using a molten-salt flux method. Single-crystal X-ray diffraction measurements confirm the presence of long-range order with a periodicity corresponding to Sr_8/7TiS₃, which is further corroborated by atomic-scale observations using scanning transmission electron microscopy. Polarization-resolved Fourier-transform infrared spectroscopy of Sr_8/7TiS₃ crystals shows Δ<i>n</i> ≈ 2.5, in excellent agreement with the theoretical predictions. Overall, these findings demonstrate the compositional tunability of optical properties in Sr_<i>x</i>TiS₃ compounds by control over atomic scale modulations and suggest that similar strategies could be extended to other compounds having modulated structures.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":16.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145327879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Postchronic Single-Walled Carbon Nanotube Exposure Causes Irreversible Malignant Transformation of Human Bronchial Epithelial Cells through DNA Methylation Changes\".","authors":"Jin Wang, Xin Tian, Jie Zhang, Lirong Tan, Nan Ouyang, Beibei Jia, Chunying Chen, Cuicui Ge, Jianxiang Li","doi":"10.1021/acsnano.5c14757","DOIUrl":"https://doi.org/10.1021/acsnano.5c14757","url":null,"abstract":"","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":16.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermally Driven Formation of Multiphase, Mixed-Dimensional Architectures from TaSe3 Nanoribbons.","authors":"Casey F Rowe,Eric V Formo,Jordan A Hachtel,Tina T Salguero","doi":"10.1021/acsnano.5c13312","DOIUrl":"https://doi.org/10.1021/acsnano.5c13312","url":null,"abstract":"Tantalum-selenium compounds, particularly TaSe2 and TaSe3, are promising materials for electronics and quantum technologies due to their charge density wave and topological properties, and they are also candidates for energy storage and electrocatalysis applications. In this study, we investigate the thermally driven structural evolution of TaSe3 nanoribbons using in situ scanning transmission electron microscopy (STEM). Low-kV STEM experiments reveal a complex nanoscale transformation pathway in which TaSe3 nanoribbons convert into multiphase, mixed-dimensional (0D-1D) tantalum-selenium architectures. Aberration-corrected STEM enables direct visualization of the underlying atomic rearrangements, while electron energy loss spectroscopy and DFT calculations corroborate the identity and stability of the product phases. Our results uncover a detailed mechanism: selenium loss from TaSe3 nanoribbons initiates surface conversion to TaSe2, which, as temperature increases, progressively continues into the nanoribbon interior. Thicker regions of TaSe2 delaminate and detach from the core material, forming a porous TaSe2 shell. At 1200 °C, the core restructures into discrete ∼20 nm Ta-self-intercalated TaSe2 nanoparticles. This core-shell transformation, driven by nanoscale confinement effects, differs markedly from the bulk decomposition pathway of TaSe3 and highlights the impact of modulating selenium loss, tantalum intercalation, and the stability of intermediate structures through confinement effects. The resulting 0D-1D heterostructure of Ta-rich nanoparticles encapsulated within porous TaSe2 tubes represents surprising and emergent complexity in a binary system. These mechanistic insights demonstrate how the controlled thermolysis of a readily accessible metal trichalcogenide precursor can yield complex, low-dimensional chalcogenide architectures.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"27 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Polarization Second Harmonic Generation Interferometry for Imaging Antiparallel Domains and Stacking Angles of 2D Heterocrystals.","authors":"Juseung Oh, Wontaek Kim, Gyouil Jeong, Yeri Lee, Jihun Kim, Hyeongjoon Kim, Hyeon Suk Shin, Sunmin Ryu","doi":"10.1021/acsnano.5c11082","DOIUrl":"https://doi.org/10.1021/acsnano.5c11082","url":null,"abstract":"<p><p>Optical second-harmonic generation (SHG) enables orientational polarimetry for crystallographic analysis and domain imaging of various materials. However, conventional SHG intensity polarimetry, which neglects phase information, fails to resolve antiparallel domains and to describe two-dimensional heterostructures, which represent a new class of van der Waals-bound composite crystals. In this work, we report dual-polarization spectral phase interferometry (DP-SPI) and establish a generalized SHG superposition model that incorporates the observables of DP-SPI. Antiparallel domains of monolayer transition metal dichalcogenides (TMDs) were successfully imaged with distinction, validating the interferometric polarimetry. From DP interferograms of TMD heterobilayers, the orientation of each layer could be determined, enabling layer-resolved probing. By employing the superposition model, we also demonstrate the photonic design and fabrication of ternary TMD heterostructures for circularly polarized SHG. These methods, providing comprehensive SHG measurements and theoretical descriptions, can be extended to heterostructures consisting of more than two constituent layers and are not limited to TMDs or 2D materials.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":16.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145327848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production-Ready Double-Sided Fabrication of Dual-Band Infrared Metaoptics Using Deep-Ultraviolet Lithography","authors":"Kai Sun, Xingzhao Yan, Jordan Scott, Jun-Yu Ou, James N. Monks, Otto L. Muskens","doi":"10.1021/acsnano.5c11908","DOIUrl":"https://doi.org/10.1021/acsnano.5c11908","url":null,"abstract":"Metaoptics, the application of metasurfaces into optical systems, is seeing an accelerating development owing to advantages in size, weight, and cost and the ability to program optical functions beyond traditional refractive optics. The transition of metaoptics from the laboratory into applications is enabled by scalable production methods based on highly reproducible semiconductor process technology. Here, we introduce a method for the fabrication of double-sided metasurfaces through deep-UV lithography as a production-ready method for achieving high-quality metaoptics. We achieve patterning of a silicon wafer on both sides with mutual alignment of around 10 μm based on tool accuracy without requiring through-wafer alignment markers other than the wafer notch. An application highlighting the benefits of double-sided design is demonstrated in the form of a dual-band metalens with independent control over focal lengths in mid- and long-wavelength infrared bands. Using multireticle stitching, we demonstrate a 40 mm diameter, large-area metalens with excellent broadband imaging performance, showing partial canceling of chromatic dispersion when used in a hybrid configuration with a BaF₂ refractive lens. Our work establishes a production-ready approach to infrared metaoptics designs and double-sided metaoptics fabrication with direct potential for translation into scalable technology for real-world applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"98 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}