Pauline Vuarin , Benjamin Rey , Amandine Herrada , François Débias , Nadia Crini , Renaud Scheifler , Clémentine Fritsch , Jean-François Lemaître , Sonia Saïd
{"title":"Exposure to toxic trace metals is negatively associated with testis mass in wild male roe deer","authors":"Pauline Vuarin , Benjamin Rey , Amandine Herrada , François Débias , Nadia Crini , Renaud Scheifler , Clémentine Fritsch , Jean-François Lemaître , Sonia Saïd","doi":"10.1016/j.envpol.2025.126825","DOIUrl":"10.1016/j.envpol.2025.126825","url":null,"abstract":"<div><div>Although trace metal toxicity has been extensively studied in laboratory settings, its long-term effects on wildlife are poorly understood. Most wild animals are likely to be exposed to low doses of trace metals throughout their lives; however, whether such chronic exposure affects fitness-related traits in natural populations remains to be investigated. In this study, we tested the relationships between trace metal burden and sex hormones, primary and secondary sexual traits in wild male roe deer. Using samples collected from 71 hunted males, we measured the hair and liver concentrations of various toxic trace metals, faecal testosterone metabolites (FTM), testis mass and antler length. We focused on cadmium (Cd), cobalt (Co), nickel (Ni) and lead (Pb) in roe deer tissues. Using linear (mixed effects) models, we found that Cd and, to a lesser extent, Co concentrations in the liver, but not in hair, were negatively associated with absolute testicular mass, a proxy of sperm production. However, metal burden, measured in either the liver or hair, was not related to antler length or FTM levels, despite their respective roles in male competitiveness for access to females and the underlying adjustments for seasonal breeding. Hence, our findings highlight the consequences of exposure to Cd and Co on male testicular function in a wild ungulate. Any alteration in male competitiveness for fertilization is expected to have lasting fitness consequences, which could subsequently alter population dynamics.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"383 ","pages":"Article 126825"},"PeriodicalIF":7.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christina Kibuta , Mario Schmidt , Tanja Fell , Frank Malz , Andrea Buettner , Martin Schlummer
{"title":"A comprehensive quantitative study of organic contaminants in marine plastics","authors":"Christina Kibuta , Mario Schmidt , Tanja Fell , Frank Malz , Andrea Buettner , Martin Schlummer","doi":"10.1016/j.envpol.2025.126827","DOIUrl":"10.1016/j.envpol.2025.126827","url":null,"abstract":"<div><div>Marine plastics act as carriers for a wide range of chemical contaminants, many of which pose serious environmental and health risks. This study investigated organic contaminants such as benzotriazole UV stabilizers (BUVs), phthalates, polycyclic aromatic hydrocarbons (PAHs), bisphenol A (BPA), and antioxidants in beach and ocean plastics collected from multiple geographic locations. A validated analytical method comprising solid-liquid extraction followed by gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography with UV detection (HPLC-UV) was employed for contaminant identification. Some detected compounds have been classified as persistent organic pollutants and substances of very high concern, including di(2-ethylhexyl) phthalate (DEHP) and UV-328. The highest levels of UV-328 detected in both ocean and beach plastics samples (1040 ± 22 μg/g and 5188 ± 65 ng/g respectively) exceeded permitted limits in plastic as set by European Chemicals Agency (ECHA). Other contaminants such as chrysene (558 ± 3 ng/g), BPA (100 ± 1 μg/g) and antioxidant degradation products like tris (2,4-ditert-butylphenyl) phosphate were also detected in some marine plastic samples. Based on these findings, this study highlights the widespread occurrence of organic contaminants in marine plastics and their potential implications for second-life applications and environmental risk. These contaminants may also impact marine ecosystems through leaching and bioaccumulation, with possible consequences for human health via the food web. Overall, the study offers insights into informing policies on plastic waste management, recycling practices, and environmental protection measures aimed at mitigating the chemical hazards associated with marine plastic pollution.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"383 ","pages":"Article 126827"},"PeriodicalIF":7.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu-Chieh Wang , Chia C. Wang , Chon-Lin Lee , Wei-Min Ching
{"title":"Exploring PFRs, ROS, PAHs, nitro-PAHs, and health risks of the nonthermal plasma intervention size-segregated smoldering incense and mosquito coils aerosols","authors":"Yu-Chieh Wang , Chia C. Wang , Chon-Lin Lee , Wei-Min Ching","doi":"10.1016/j.envpol.2025.126820","DOIUrl":"10.1016/j.envpol.2025.126820","url":null,"abstract":"<div><div>Persistent free radicals (PFRs) are emerging pollutants, and particulate matter (PM) containing PFRs can generate reactive oxygen species (ROS), which may pose health risks. This study analyzes emissions of size-segregated aerosols from indoor sources, including incense and mosquito coils, during nonthermal plasma (NTP) intervention. The focus is on PM-bound PFRs, ROS, polycyclic aromatic hydrocarbons (PAHs), and nitrated polycyclic aromatic hydrocarbons (nitro-PAHs). The results show that emissions primarily consist of PM<sub>2.5</sub>, with PM<sub>1</sub> being the dominant fraction within PM<sub>2.5</sub> (73–93 % PM<sub>2.5</sub>). ROS analysis indicated that PM<sub>1</sub> generated OH, R, and H free radicals, while PM<sub>1-2.5</sub> generated only OH free radicals. NTP intervention reduced total suspended particles and PM<sub>2.5</sub> concentrations while lowering PFR concentrations in the air. Analysis of PAHs and nitro-PAHs indicated that reactive species produced by NTP promoted the formation of nitro-PAHs. A risk assessment using cigarette exposure equivalents showed that PFR exposure during worship was roughly equivalent to 0.0076 cigarettes. Using a personal NTP air purifier reduced exposure by 64 %. These findings highlight the health risks associated with indoor incense and mosquito coil use and emphasize the importance of NTP intervention in air purification strategies, providing valuable insights for improving air quality assessments.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"383 ","pages":"Article 126820"},"PeriodicalIF":7.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kelp mariculture enhances the burial ability of polycyclic aromatic hydrocarbons: Evidence from Ailian Bay, China","authors":"Yuru Li, Yuqiang Tao","doi":"10.1016/j.envpol.2025.126824","DOIUrl":"10.1016/j.envpol.2025.126824","url":null,"abstract":"<div><div>Kelp mariculture plays an important role in carbon sequestration. Burial by coastal sediments is an important way to reduce the risk of organic contaminants. However, the influences of kelp mariculture-induced carbon dynamics on the organic contaminant burial remain largely unknown. Here, we demonstrated that long-term kelp (<em>Saccharina japonica</em>) mariculture has enhanced the burial ability (burial flux/emission density) of the sixteen priority polycyclic aromatic hydrocarbons (PAHs) in coastal sediments, as evidenced by the study from a mariculture base in Ailian Bay, China. We reconstructed the historical production of kelp mariculture in Ailian Bay by the kelp environment DNA (eDNA) in the sediment core. The quantity of kelp eDNA increased from 0.02 ± 0.01 to 0.06 ± 0.01 ng g<sup>−1</sup> in the period from 1989 to 2020 (<em>p</em> < 0.05), indicating that kelp mariculture had expanded during this period. The total organic carbon (TOC) in the sediment core of Ailian Bay varied from 16.1 to 24.0 mg g<sup>−1</sup>. The average burial ability of the individual PAHs varied from 0.01 ± 0.02 to 0.10 ± 0.10 in Ailian Bay. The expansion of kelp mariculture enhanced the content of TOC and the recalcitrant humic acid-like carbon components, which promoted the burial ability of the PAHs (except for naphthalene, fluorene, anthracene, and dibenzo[a,h]anthracene) in the period from 1989 to 2020. Kelp mariculture activities influenced more on the burial ability of the lower molecular weight PAHs than that of the higher molecular weight PAHs.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"383 ","pages":"Article 126824"},"PeriodicalIF":7.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Songyan Huan , Biao Zhang , Kun Huang , Huihua Yang , Yuanyuan Zhang , Jie Wang , Miao Liu , Xiaomin Zhang
{"title":"Associations of per- and perfluoroalkyl substances with serum alanine and aspartate aminotransferase levels and the potential mediating role of cytokines in children","authors":"Songyan Huan , Biao Zhang , Kun Huang , Huihua Yang , Yuanyuan Zhang , Jie Wang , Miao Liu , Xiaomin Zhang","doi":"10.1016/j.envpol.2025.126815","DOIUrl":"10.1016/j.envpol.2025.126815","url":null,"abstract":"<div><div>Evidence on the association of per- and perfluoroalkyl substances (PFAS) with alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in children, and the underlying mechanisms are still unknown. This study aims to examine the associations of PFAS with ALT and AST, and the mediating role of cytokines in healthy children. A panel study was carried out using three repeated measurements of 11 plasma PFAS, serum ALT and AST, and 48 cytokines among 134 children in Wuhan, China. Linear mixed-effect models, Bayesian kernel machine regression, and weighted quantile sum regression were used to explore the individual and combined associations of PFAS with ALT and AST. The mediating function of cytokines in these associations was assessed using causal mediation analysis. Perfluorononanoic acid (PFNA), perfluorohexane sulfonate (PFHxS), perfluoroundecanoic acid (PFUnDA), and perfluorododecanoic acid (PFDoDA) were found to have dose-response relationships with elevated ALT. PFAS mixture was associated with increased ALT in two mixed exposure models, with PFHxS identified as the major contributor. Such associations of PFAS and ALT were more evident in children who were overweight or obese and consumed fish ≥1 day/week. An integrated analysis revealed a group of children with elevated ALT levels, characterized by high PFAS exposure and increased cytokine levels. Four cytokines, including CCL 4, CCL27, IL-2Rα, and IL-9, were found to be associated with elevated levels of PFNA, PFHxS, PFUnDA, and ALT. Among them, CCL27 and IL-9 mediated 8.96 % and 12.06 % of the association of PFHxS with ALT, respectively. Our findings suggested that PFAS exposure was positively associated with ALT, and CCL27 and IL-9 might partially mediate PFAS-associated increased ALT among children.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"383 ","pages":"Article 126815"},"PeriodicalIF":7.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cengiz Kaya, Ferhat Ugurlar, Muhammed Ashraf, Mohamed A. El-Sheikh, Andrzej Bajguz, Parvaiz Ahmad
{"title":"Corrigendum to ‘The participation of nitric oxide in hydrogen sulphide-mediated chromium tolerance in pepper (Capsicum annuum L) plants by modulating subcellular distribution of chromium and the ascorbate-glutathione cycle’ [Environ. Pollut., 313 (2022) 120229]","authors":"Cengiz Kaya, Ferhat Ugurlar, Muhammed Ashraf, Mohamed A. El-Sheikh, Andrzej Bajguz, Parvaiz Ahmad","doi":"10.1016/j.envpol.2025.126797","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126797","url":null,"abstract":"No Abstract","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"22 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of long-term submerge-emerge alternation on the fate of per- and polyfluoroalkyl substances (PFASs) in sediment-water systems: Insight from dissolved organic matter","authors":"Ye-bing Shi , Zu-lin Hua , Zi-wei Chen","doi":"10.1016/j.envpol.2025.126822","DOIUrl":"10.1016/j.envpol.2025.126822","url":null,"abstract":"<div><div>Long-term submerge-emerge alternations have universal eco-environmental significance in the global aquatic cycle. However, the insight of interaction between dissolved organic matter (DOM) and per- and polyfluoroalkyl substances (PFASs) within this process is limited. In this study, through comparative experiments of long-term submerge-emerge alternation (ASE) versus continued submergence (CS), we explored the release of per- and polyfluoroalkyl substances (PFASs) from contaminated sediment and used spectral technologies and high-resolution mass spectrometry to reveal the DOM contribution in this process. Results indicated that long-term submerge-emerge alternation greatly enhanced PFAS release from contaminated sediments and their migration into aqueous phases. In the ASE group, the ∑PFAS concentration in sediment decreased to 437.8 μg/kg dw, a reduction of 66.32 %, compared with 774.93 μg/kg dw in the CS group, representing a decrease of 40.39 %. The ∑PFAS concentrations in porewater and overlying water were significantly higher in the ASE group (1592.51 ± 18.11 μg/L and 458.06 ± 32.52 μg/L) compared with those in the CS group (1073.94 ± 39.08 μg/L and 235.26 ± 8.10 μg/L), particularly for short-chain PFASs. Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry and spectral analysis of DOM revealed that long-term submerge-emerge alternation substantially altered the DOM composition and characteristics. Specifically, the higher NOSC (−0.34), DBE (8.43), AI<sub>mod</sub>>0.5, and O/C (0.4335) values indicated stronger polarity, increased aromaticity, and reduced stability of DOM. The decreased presence of protein and CHOS formula compounds reduced co-adsorption, and the increased abundance of carboxyl and hydroxyl groups intensified competitive adsorption between PFASs and DOM could be the potential mechanism by which long-term submerge-emerge alternation affected sediment PFAS release. These findings provide novel insights into the sedimentary geochemical cycling of DOM and PFASs under long-term submerge-emerge alternation.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"383 ","pages":"Article 126822"},"PeriodicalIF":7.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rong Li , Quanzhen Liu , Xiong Xu , Yongchang Xie , Lihua Lin , Mengru Yang , Donghong Wang
{"title":"Unraveling the source-terminal PAH pollution from coal chemical wastewater in the Yellow River Basin via molecular fingerprint concentration analysis","authors":"Rong Li , Quanzhen Liu , Xiong Xu , Yongchang Xie , Lihua Lin , Mengru Yang , Donghong Wang","doi":"10.1016/j.envpol.2025.126821","DOIUrl":"10.1016/j.envpol.2025.126821","url":null,"abstract":"<div><div>Precise source identification of coal chemical water (CCW) pollution is crucial for unraveling contaminant transport and developing effective remediation strategies. While conventional fluorescent fingerprint technology provides accurate source recognition, it remains constrained by existing databases. Here, this study proposes a molecular fingerprint concentration method, achieving source discrimination through correlation profiling of source-terminal waters. The method was applied to trace 16 priority PAHs and 4 derivatives in the upper and middle reaches of the Yellow River Basin. Results indicated that PAH concentrations ranged from 3.96 to 4160 ng L<sup>−1</sup>, whereas derivatives concentrations varied between 1.34 and 9420 ng L<sup>−1</sup>. Spatial-temporal variations were significant but independent of water quality parameters such as pH and temperature. While PAH pollution generally posed low risks, specific areas exhibited elevated levels, necessitating targeted mitigation strategies. Molecular fingerprint concentration analysis revealed a strong correlation (<em>R</em><sup>2</sup> > 0.8) between CCW and surface water, confirming that wastewater is a major contributor to PAH pollution. However, modest correlations (0.8 > <em>R</em><sup>2</sup> > 0.6) between CCW and source/tap water indicated a more constrained impact. This analysis successfully tracked CCW as a pollution source, provides critical data for industrial optimization, and advances contaminant source tracking methodologies.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"383 ","pages":"Article 126821"},"PeriodicalIF":7.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding PM-bound trace element solubilities: Controls, anthropogenic and natural sources","authors":"Diksha Haswani, Ramya Sunder Raman","doi":"10.1016/j.envpol.2025.126823","DOIUrl":"10.1016/j.envpol.2025.126823","url":null,"abstract":"<div><div>Heavy metal pollution in fine particulate matter (PM<sub>2.5</sub>) is a subject of great concern due to rapid urbanization and industrialization. To evaluate the chemical characteristics and sources of PM<sub>2.5</sub>-bound trace elements (TEs) in PM<sub>2.5,</sub> chemical fractions of two-year (2019–2020) key TEs (Al, Si, Ca, Fe, Ti, K, S, P, Mn, Ni, V, Cr, Cu, Zn and Pb) were investigated. A four-step sequential extraction method was adopted to extract and analyse TEs exchangeable, reducible, oxidisable and residual fractions using inductively coupled plasma optical emission spectrometry. Positive Matrix Factorization was applied to the fractional concentrations of individual elements to apportion TE sources in PM<sub>2.5.</sub> The model resolved factors were identified as i) mineral dust ii) agricultural crop burning residues iii) vehicular emission iv) coal combustion residues, and v) industrial emission. Mobility of elements from geogenic sources increased during 2020 (COVID 19 lockdowns year), likely due to the formation of soluble secondary inorganic species, while mobility of elements from anthropogenic sources decreased. These findings suggest that anthropogenic activities influence not only TE abundance but also their solubility and bioavailability.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"383 ","pages":"Article 126823"},"PeriodicalIF":7.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiaying Wu , Xinyue You , Yiyi Cao , Jing Xi , Xiang Chen , Xinyu Zhang , Yang Luan
{"title":"High-throughput neurotoxicity study of neonicotinoids in C. elegans: Oxidative stress and serotonergic neuronal damage as key mechanisms","authors":"Jiaying Wu , Xinyue You , Yiyi Cao , Jing Xi , Xiang Chen , Xinyu Zhang , Yang Luan","doi":"10.1016/j.envpol.2025.126814","DOIUrl":"10.1016/j.envpol.2025.126814","url":null,"abstract":"<div><div>Neonicotinoids (NEOs) have been widely used as effective pesticides for decades, yet their adverse effects on non-target organisms remain a growing concern. Although the neurotoxicity of certain NEOs has been established, the potential neurotoxicity of the remaining large fraction of NEOs, as well as their underlying mechanisms, are yet to be clarified. In the present study, we employed a high-throughput toxicity screening platform to evaluate the neurotoxic potential of eight commonly used neonicotinoid insecticides in <em>Caenorhabditis elegans</em>. Our results revealed that acetamiprid (ACE), dinotefuran (DIN), clothianidin (CLO) and thiacloprid (THI) significantly impaired locomotion behavior in worms. Upon examining the potential mechanism of action, we found that ACE, CLO and THI could induce serotonergic neuronal damage, while cholinergic, dopaminergic and GABAergic neurons remained unaffected. Additionally, these three NEOs reduced bend frequency by predominantly enhancing oxidative stress, which was partially mitigated by the antioxidant N-acetyl-L-cysteine. In the neurotransmitter system, ACE mainly upregulated the mRNA expression of synthesis- and transport-related genes of neurotransmitters, while THI increased transport-related gene expression and decreased GABAergic receptor gene expression. In contrast, DIN elevated total acetylcholine levels without significantly altering gene expression, suggesting a distinct mechanism. In summary, our findings highlight that ACE, CLO and THI exert neurotoxicity through oxidative stress and serotonergic neuronal damage, while DIN primarily disrupts the neurotransmitter system. Our study provides insights into the high-throughput screening of NEO-induced neurotoxicity, offering a critical foundation for future in-depth studies to fully elucidate the toxic mechanisms of NEOs and to assess their environmental and health risks.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"383 ","pages":"Article 126814"},"PeriodicalIF":7.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}