Environmental Pollution最新文献

{"title":"Empirical analysis of the influence mechanism of vegetation and environment on negative air ion in warm temperate forest ecosystems","authors":"LuLu Cai ,&nbsp;GuangYao Shi ,&nbsp;JinSong Zhang ,&nbsp;LingTong Du ,&nbsp;XiLu Ni ,&nbsp;Yang Hu ,&nbsp;DanBo Pang ,&nbsp;JiangHong Meng","doi":"10.1016/j.envpol.2024.125273","DOIUrl":"10.1016/j.envpol.2024.125273","url":null,"abstract":"<div><div>Air pollution presents a significant threat to public health in megacities globally. Negative air ions (NAI), often referred to as “air vitamins,” are recognized for their effectiveness in alleviating the harmful effects of air pollution. Forest ecosystems serve as natural generators of NAI, with both vegetation and environmental conditions playing critical roles in the formation and persistence of NAI. Gaining a comprehensive understanding of how forest ecosystems regulate NAI production is essential for leveraging their potential to enhance air quality. However, the intricate dynamics of forest ecosystems, along with seasonal fluctuations in vegetation and environmental factors, introduce uncertainties in NAI generation. This study utilized long-term observational data to explore the relationships between environmental variables, vegetation photosynthetic capacity (using solar-induced chlorophyll fluorescence, SIF), and NAI concentrations. By employing machine learning algorithms, we analyzed the spatiotemporal distribution of NAI, identifying the key contributing factors and their relative influence within forest ecosystems. The results revealed distinct seasonal variations in NAI levels, with higher values in summer and lower in winter. SIF and PM_2.5 primarily influenced NAI through direct effects across seasons, whereas ambient temperature (TA), relative humidity, photosynthetically active radiation (PAR), and soil moisture predominantly impacted SIF on NAI through indirect effects in summer. TA was the primary influencing factor in spring and winter, contributing 28% and 25%, respectively, while PAR played a more significant role in summer and autumn, accounting for 37% and 27%. Vegetation had a greater impact on NAI levels during spring and summer, contributing 66% and 62%, whereas environmental factors dominated in autumn and winter, with contributions of 83% and 89%. This study offers both a theoretical foundation and technical guidance for enhancing the role of forest ecosystems in improving air quality and human living environments.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"363 ","pages":"Article 125273"},"PeriodicalIF":7.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142597614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure of Enchytraeus crypticus to ciprofloxacin - A multi- and transgenerational study","authors":"Marcela Ravanelli Martins,&nbsp;Marta Siviero Guilherme Pires","doi":"10.1016/j.envpol.2024.125270","DOIUrl":"10.1016/j.envpol.2024.125270","url":null,"abstract":"<div><div>The increased consumption of antibiotics and their partial metabolism by the human and animal body have led to the frequent identification of such compounds in various environmental matrices. Ciprofloxacin (CIP) is one of the most widely used antibiotics worldwide and it has low mobility and high sorption to soil, leading to the potential to accumulate and persist on organic fertilizers (manure and sewage sludge) and agricultural soils. Therefore, the presence of CIP in the agricultural environment has become an emerging concern as it may negatively affect soil organisms and soil quality, and contribute to the spread of antibiotic-resistant bacteria, thus threatening food security and public health. In this study, we aimed to evaluate the multigenerational and transgenerational effects of CIP on the reproduction of <em>Enchytraeus crypticus</em> to properly assess the long-term impacts of such exposure. Our results for the multigenerational test showed that the reproduction of the organisms was affected from the third to the last (sixth) generation, highlighting the importance of long-term evaluation. There was also evidence of tolerance to reproduction of <em>E. crypticus</em>, as there was no statistical difference between concentrations for all generations, including for among the last three generations themselves. For the transgenerational tests, almost all results showed no statistical difference from the controls, indicating that the effects of CIP may be reversible when the organisms are transferred to clean media. However, since the last generations in the transgenerational tests showed significant differences from the first of the multigenerational tests, the adverse effects may still persist to some extent in the subsequent generations. Thus, when evaluating the effects of CIP on soil media, its persistence and behavior in this matrix must be considered. We strongly recommend that further long-term exposure studies be conducted and considered in regulatory decision-making, especially for persistent compounds.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"363 ","pages":"Article 125270"},"PeriodicalIF":7.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142597563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fifty percent overestimation of black carbon concentration measured in aerosols of the Tibetan Plateau","authors":"Zhaofu Hu ,&nbsp;Shichang Kang ,&nbsp;Chaoliu Li ,&nbsp;Chao Zhang ,&nbsp;Fangping Yan ,&nbsp;Pengfei Chen ,&nbsp;Duoji Danmuzhen","doi":"10.1016/j.envpol.2024.125277","DOIUrl":"10.1016/j.envpol.2024.125277","url":null,"abstract":"<div><div>Elemental carbon (EC), also known as black carbon, plays an important role in climate change. Accurately assessing EC concentration in aerosols remains challenging due to the overestimations caused by carbonates and organic carbon (OC) during thermal-optical measurement in the Tibetan Plateau (TP). This study evaluates the extent of EC overestimated by carbonates and OC at four remote sites (Nyalamu, Lulang, Everest and Ngari) in southern and western of the TP using different treatments. The average overestimation of EC concentration due to acid treatment was consistent across all sites (25.5 ± 2.4 %). After correction, the proportion of EC overestimated by carbonates were approximately 8.5 ± 7.3 %, 12.3 ± 6.9 %, 18.1 ± 11.8 % and 22.7 ± 13.3 %, respectively, revealing an increasing trend from humid to arid regions. Methanol-soluble OC (MSOC) concentrations were significantly correlated with the reduction of EC concentrations, indicating that the methanol extraction effectively mitigates EC overestimation. Seasonal variation of carbonaceous aerosol concentrations was significantly affected by sources from South Asia. Despite the variations in climate and aerosol sources, the average overestimations of measured EC concentration by carbonates and OC were similar at Nyalamu (49.4 ± 14.0 %), Lulang (47.8 ± 8.4 %), Everest (48.7 ± 15.9 %) and Ngari (49.3 ± 13.7 %) sites. Therefore, the actual EC concentrations were only about 51.2 ± 13.1 % of the original values. This estimation will significantly enhance the contribution of brown carbon (BrC) to radiative forcing relative to EC, highlighting a critical area for future research. Investigating the actual concentrations of EC in the TP provides critical data to support model simulation and validate model accuracy, further enhancing our understanding of EC's impacts on climate warming and glacier melting.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"363 ","pages":"Article 125277"},"PeriodicalIF":7.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quantitative classification method of land uses and assessment of per-and poly-fluoroalkyl substances (PFAS) occurrence in freshwater environments","authors":"Paula Sardiña,&nbsp;Simon Sharp,&nbsp;Minna Saaristo,&nbsp;Timothy Coggan,&nbsp;Molly Hoak,&nbsp;Paul Leahy","doi":"10.1016/j.envpol.2024.125272","DOIUrl":"10.1016/j.envpol.2024.125272","url":null,"abstract":"<div><div>We developed a quantitative method for classifying land uses for PFAS-related investigations in freshwater environments and determined PFAS ambient concentrations associated with specific land-use classes. Furthermore, our study presents a comprehensive assessment of the ambient occurrence and risks of PFAS mixtures beyond the usually studied PFOS-PFOA mixtures. Eighty-five inland (freshwater only) sites were sampled for water, sediment, and riparian soil in Victoria, south-east Australia, and analyzed for 33 PFAS. PFAS were detected in 91% of water samples, 34% of sediment samples, and 28% of riparian soil samples. Four land-use classes were defined: remote, agricultural, mixed, and urban. In the remote land-use class, only PFOS was detected at a low ambient concentration (0.0002 μg/L) in one water sample. Short-chain PFCA were frequently detected in the agricultural and mixed water samples. PFBA had the highest median ambient concentration in both land uses (ca. 0.01 μg/L), contributing to both ΣPFAS (40%) and ΣPFCA (50%) concentrations. In the urban land-use class, several congeners (PFBA, PFPeA, PFHxA, PFOA, PFHxS, and PFOS) had median ambient concentrations at or close to 0.01 μg/L and contributed similarly to ΣPFAS (10–20%). Elevated risk to the aquatic environment was found only for PFOS in two mixed and eight urban sites. This pattern was consistent with the finding for PFAS mixtures, where the elevated risk was driven by PFOS at those same sites. Our study provides critical information about environmentally relevant ambient concentrations and PFAS mixtures. This information, together with the land-use classification approach presented herein, can be used as reference levels for several critical purposes, including identifying PFAS-contaminated sites, informing land use planning and development decisions, setting standards and guidelines, and tracking changes over time.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"363 ","pages":"Article 125272"},"PeriodicalIF":7.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity of population exposure to particulate matter pollution and its socioeconomic driving mechanism in Shaanxi Province, China","authors":"Yu Liu ,&nbsp;Liwei Zhang ,&nbsp;Zexuan Zang ,&nbsp;Zhuangzhuang Wang ,&nbsp;Ying Luo ,&nbsp;Hao Wang ,&nbsp;Lei Jiao","doi":"10.1016/j.envpol.2024.125274","DOIUrl":"10.1016/j.envpol.2024.125274","url":null,"abstract":"<div><div>The rapid pace of economic and social development has led to a surge of particulate matter (PM) pollution incidents, which is detrimental to human health. Air quality in China has improved in recent years, but differences in PM exposure remain due to spatial heterogeneity in pollution and population. The identification of socioeconomic factors associated with PM pollution has attracted widespread attention. Current research predominantly targets cities, overlooking regional and county scale disparities. An analytical framework is established to evaluate the spatial heterogeneity in PM exposure and to identify the socioeconomic factors contributing to its pollution. The results revealed that: (1) the Theil index increased from 0.06 to 0.12, indicating a gradual increase in the inequality of PM exposure in Shaanxi Province. The differences within the Guanzhong Plain are obvious and the interregional differences substantially outweigh the intraregional variations. (2) Energy transition is pivotal in curbing air pollution in a region and economic growth consistently fuels particulate emissions. (3) For effective pollution mitigation, further emphasis on vegetation preservation and environmental inputs is imperative. The findings of this research provide decision support for optimizing air pollution control measures at the county scale.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"363 ","pages":"Article 125274"},"PeriodicalIF":7.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particulate matter exposure and its consequences on hippocampal neurogenesis and cognitive function in experimental models","authors":"Charu Jaiswal,&nbsp;Abhishek Kumar Singh","doi":"10.1016/j.envpol.2024.125275","DOIUrl":"10.1016/j.envpol.2024.125275","url":null,"abstract":"<div><div>Exposure to air pollution is thought to cause millions of deaths globally each year. According to the Who 2018, approximately 7 million deaths annually are caused predominantly by noncommunicable diseases due to air pollution. Exposure to air particulate matter 2.5 (PM2.5) has been strongly associated with increased mortality and has significant effects on brain health. Air pollution, particularly ultrafine particulate matter, has emerged as a serious environmental concern with profound implications for human health. Studies in animal models have indicated that exposure to these pollutants during gestational development impacts prenatal and postnatal brain development. In particular, air pollution has been increasingly identified as a potential causative factor, as it affects neurogenesis in the brain's hippocampal region. The hippocampus is highly vulnerable to PM exposure, and any alteration in the structure or function of this region leads to various neurodevelopmental defects and neurodegenerative disorders via oxidative stress, microglial activation, neuronal death, and differential expression of genes. The neurogenesis process involves several steps, such as proliferation, differentiation, migration, synaptogenesis, and neuritogenesis. If any step of the neurogenesis process is hampered by environmental exposure or other factors, it can lead to neurodevelopmental defects, neurodegenerative disorders, and cognitive decline. One significant contributor to these alterations is air pollution, which ranks as the leading environmental risk factor worldwide. Some of the most common effects include oxidative stress, neuroinflammation, depressive behavior, altered cognitive processes, and microglial activation. This review explores how prenatal and postnatal PM exposure affects the hippocampal regions of the brain and the defects associated with exposure.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"363 ","pages":"Article 125275"},"PeriodicalIF":7.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic insight into the enrichment of antibiotic resistance genes in activated sludge upon exposure to nanoplastics","authors":"Jian Song ,&nbsp;Zefeng Huang ,&nbsp;Yuanyuan Gao ,&nbsp;Weigang Wang ,&nbsp;Gang Guo ,&nbsp;Yi Duan ,&nbsp;Shuai Zhou ,&nbsp;Zhenping Tang","doi":"10.1016/j.envpol.2024.125260","DOIUrl":"10.1016/j.envpol.2024.125260","url":null,"abstract":"<div><div>Activated sludge is an important reservoir for the co-occurring emerging contaminants including nanoplastics (NPs) and antibiotic resistance genes (ARGs). However, the impacts and potential mechanisms of NPs on the fate of ARGs in activated sludge are not fully understood. Herein, we used metagenomic approach to investigate the responses of ARGs, host bacteria, mobile genetic elements (MGEs), and functional genes to polystyrene (PS) NPs at environmentally relevant (0.5 mg/L) and high stress concentrations (50 mg/L) in activated sludge. The results showed that 0.5 and 50 mg/L PS NPs increased the relative abundance of ARGs in the activated sludge by 58.68% and 46.52%, respectively (<em>p</em> &lt; 0.05). Host tracking analysis elucidated that the hosts of ARGs were significantly enriched by PS NPs (<em>p</em> &lt; 0.05), with <em>Proteobacteria</em> being the predominant host bacteria. Additionally, the occurrence of new ARGs hosts and the enrichment of MGEs and functional genes (i.e., genes related to SOS response, cell membrane permeability, and secretion system, etc.) indicated that PS NPs promoted horizontal gene transfer (HGT) of ARGs. Finally, path modeling analysis revealed that the proliferation of ARGs caused by PS NPs was primarily attributed to the enhancement of HGT and the enrichment of host bacteria. Our findings contribute to a comprehensive understanding of the spread risk of ARGs in activated sludge under NPs pollution.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"363 ","pages":"Article 125260"},"PeriodicalIF":7.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress mediates the association of organophosphate flame retardants with metabolic obesity in U.S. adults: A combined epidemiologic and bioinformatic study","authors":"Chuhang Lin ,&nbsp;Ziang Guo ,&nbsp;Haiying Li ,&nbsp;Zhengtian Lai ,&nbsp;Jing Zhang ,&nbsp;Shen Xie ,&nbsp;Yuxuan Tan ,&nbsp;Chunxia Jing","doi":"10.1016/j.envpol.2024.125267","DOIUrl":"10.1016/j.envpol.2024.125267","url":null,"abstract":"<div><div>Obesity is a global public health issue, with limited epidemiologic studies on the relationship and mechanisms between organophosphate flame retardants (OPFRs) and metabolic obesity phenotypes (MOPs). We aimed to explore the link between OPFRs metabolite (m-OPFRs) and MOPs using a combined epidemiologic and bioinformatic approach. We used cross-sectional survey data from the U.S. National Health and Nutrition Examination Survey (2011–2018) to analyze the relationship between m-OPFRs and metabolic health obesity (MHO), as well as metabolic unhealthy obesity (MUO). The dataset encompasses eligible adults to assess the impact of individual, mixed, and mediated effects on the outcome variables through multivariate logistic regression, Bayesian kernel machine regression (BKMR), and mediation analysis. Multiple logistic regression models, stratified by tertiles of exposure showed that bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) levels in the body significantly increased the risk of MHO, with OR and 95%CI of 1.454 (1.082, 1.953) for the second tertile (T2) and 1.598 (1.126, 2.268) for the third tertile (T3), compared to the first tertile (T1). Increased levels of BDCIPP in T3 (1.452(1.013, 2.081)) are associated with MUO, compared to T1. Mixed m-OPFRs and MHO risk in BMKR were positively correlated, with BDCIPP being the primary contributor. We found that the serum uric acid (SUA) and white blood cell count (WBC) indicators significantly mediated the association between BDCIPP and MHO (P &lt; 0.05). Our study suggests that OPFRs, either individual or mixed, are associated with two distinct MOPs, with oxidative stress playing an important role. In addition, in silico analysis was used to screen for shared genes, and eight shared genes and eleven biological pathways identified during the screening process were used to construct the adverse outcome pathway, which suggests that exposure to OPFRs may activate the peroxisome proliferator-activated receptor (PPAR) pathway, thereby increasing the risk of obesity. Further studies are needed to validate our findings.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"363 ","pages":"Article 125267"},"PeriodicalIF":7.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic analysis of the dichotomous role of uranium in regulating intracellular and extracellular antibiotic resistance genes in activated sludge","authors":"Shuai Zhou ,&nbsp;Zefeng Huang ,&nbsp;Jian Song ,&nbsp;Yi Duan ,&nbsp;Gang Guo ,&nbsp;Weigang Wang ,&nbsp;Xiulan Ou ,&nbsp;Yuanyuan Gao ,&nbsp;Yinglong Su","doi":"10.1016/j.envpol.2024.125258","DOIUrl":"10.1016/j.envpol.2024.125258","url":null,"abstract":"<div><div>Antibiotic resistance genes (ARGs) in activated sludge include intracellular ARGs (iARGs) and extracellular ARGs (eARGs), both of which are recognized as emerging pollutants. While the activated sludge process has been commonly considered for treating wastewater contaminated with radionuclide, the effects and mechanisms of radioactive heavy metals on the fate of iARGs and eARGs (i/e-ARGs) in activated sludge are largely elusive. Here, the distribution, mobility, and hosts of i/e-ARGs in activated sludge during environmental concentrations (50 μg/L and 5000 μg/L) of radioactive uranium (U) stress were explored via metagenomics. The results revealed that the total relative abundance of iARGs and eARGs decreased by 11.62% and 10.41%, respectively, after 90 days of 50 μg/L of U treatment. In contrast, both i/e-multi- and tetracycline ARGs remarkably increased after being exposed to 5000 μg/L of U. Additionally, exposure to 5000 μg/L of U triggered notable decrease in i/e-insertion sequences and plasmids abundance, but significantly enriched i/e-integrons (<em>p</em> &lt; 0.05). Partial least squares pathway modelling indicated that the prevalence of iARGs and eARGs in activated sludge was primarily driven by bacterial hosts and functional genes, respectively. Our findings revealed the dichotomous variation landscape and mechanisms of i/e-ARGs dynamics in activated sludge during U exposure, offering valuable insights for controlling ARGs risk during radioactive wastewater treatment.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"363 ","pages":"Article 125258"},"PeriodicalIF":7.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between fixed dental prostheses, blood lead levels, and liver function: Mediating effects and gender differences","authors":"Wansu Sun ,&nbsp;Fei Xu ,&nbsp;Ruixin Zhang ,&nbsp;Yi Qian ,&nbsp;Hengguo Zhang ,&nbsp;Lilin Hong","doi":"10.1016/j.envpol.2024.125268","DOIUrl":"10.1016/j.envpol.2024.125268","url":null,"abstract":"<div><div>Metal alloys, pure titanium, metal-ceramics, and ceramic materials are used for fixed dental prostheses, which contained lead and potentially involved hepatotoxicity. To investigate the connection between fixed dental prostheses, blood lead levels, and liver function. A cross-sectional study enrolled 3624 American adults were conducted. Multivariate linear regression models and smooth curve fittings were used to describe correlations between the number of fixed dental prostheses, blood lead levels, and four liver function markers. Mediation analysis suggested an intermediary association of blood lead levels between prosthesis count and liver function. Here, number of fixed dental prostheses was significantly positive correlated with blood lead levels (p &lt; 0.0001), but specifically negative correlated with alanine aminotransferase, lactate dehydrogenase, and gamma glutamyl transferase levels in males. Moreover, mediation analysis confirmed a mediating role for blood lead levels in the association between the number of prostheses and alanine aminotransferase levels in males only, with a mediation effect rate of 74.27% (p = 0.0020). An increased count of fixed prostheses is associated with changes in liver function markers in a gender-dependent manner, with blood lead levels serving as a potential mediator in males.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"363 ","pages":"Article 125268"},"PeriodicalIF":7.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}