Wendong Ge, Noah S. Prime, Steven J. Smith, Junfeng Liu, Yang Ren, Yuhan Zhou, Huihuang Wu, Xian Wang, Chen Gang
{"title":"The short-term comprehensive impact of the phase-out of global coal combustion on air pollution and climate change","authors":"Wendong Ge, Noah S. Prime, Steven J. Smith, Junfeng Liu, Yang Ren, Yuhan Zhou, Huihuang Wu, Xian Wang, Chen Gang","doi":"10.1016/j.envpol.2025.125669","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.125669","url":null,"abstract":"With the continuous intensification of global warming, the reduction and ultimate phase-out of coal combustion is an inevitable trend in the future global energy transformation. This study comprehensively analyzed the impact of phasing out coal combustion on global emissions and concentrations of air pollutants, radiative fluxes, meteorology and climate using Community Earth System Model 2 (CESM2). The results indicate that after the global phase-out of coal combustion, there is a marked decrease in the concentrations of sulfur dioxide (SO<sub>2</sub>), nitrogen oxides (NO<sub>x</sub>) and fine particulate matter (PM<sub>2.5</sub>), with some regions experiencing a reduction of exceeding 50%. There is no significant change in global ozone (O<sub>3</sub>) concentration. There are decreasing AOD and positive radiative fluxes globally in the short term, though the cloud contributes minor negative radiative fluxes. The global air temperature may increase by approximately (0.02±0.15) °C on average with regional and seasonal variations, and the precipitation may potentially increase by approximately (2.7±40.6) mm yr<sup>-1</sup> globally and over 20% in equatorial regions in the short term. But combined with the decreasing trend of cloud water content in the Northern Hemisphere, it indicates a potential increase in the extremity of precipitation events. This study provides references for global control of air pollution, mitigation strategies of climate change, and transformation of energy structures under the objective of “carbon neutrality”, such as focusing on the negative climate impacts of exacerbating regional warming and increasing extreme precipitation resulting from the rapid reduction of aerosols in the short term.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"13 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Weighted Comprehensive Risk Assessment and Pollution Analysis of Long-Term Printing and Dyeing Sludge Landfills in an Industrialized Chinese City","authors":"Qian Xiang, Dongdong Fan, Liming Zhu, Tongsheng Zhang, Danni Shen, Hui Wang, Bin Dong","doi":"10.1016/j.envpol.2025.125665","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.125665","url":null,"abstract":"Sludge landfilling is widely used in China, accounting for approximately 65% of total sludge disposal, due to its simplicity and cost-effectiveness. However, with increasing land scarcity and stricter environmental regulations, the Chinese government has emphasized reducing sludge landfilling. Despite these efforts, sludge historically disposed of in landfills continues to pose risks, including heavy metal leaching and contamination of groundwater and soil. Comprehensive risk assessments for multi-contaminant industrial sludge in long-term landfills remain limited. This study conducted a risk survey and pollution assessment at a long-term sludge landfill in a typical industrial city in China. The sludge at the site was found to be mildly alkaline (pH 7.30-8.29) and had a low calorific value (1.37E+03-1.61E+03 kcal/kg), with significant dewatering challenges (1.23×10<sup>15</sup> s<sup>2</sup>/g). The overall pollution load was relatively low, with a regional Pollution Load Index (PLI) of 0.65. However, due to extreme pollutants, the Nemerow Pollution Index (NPI) reached 9.49, indicating severe pollution. The single-factor index assessment indicates high pollution levels for Zn, Sb, BaP, and total petroleum hydrocarbons (TPHs). Ecological risk is primarily associated with Hg, Sb, BaP, InP, and TPHs. However, the weighted comprehensive risk assessment method proposed in the study identifies Zn, Pb, Sb, and TPHs as priority pollutants, with the main pollution hotspots being SZ4, SZ5, and SZ9. Some pollutants, such as Ni, antibiotics, polychlorinated biphenyls, and certain polycyclic aromatic hydrocarbons, were not detected in the sludge. Through principal component analysis and positive matrix factorization analysis, multiple sources of pollution at the landfill were identified, including the dyeing industry, electronics manufacturing, traffic emissions, fuel combustion, and urban runoff. This analysis highlights heavy metal pollution (Cr, Hg, Pb) and organic pollutants (PAHs, TPHs, DBA) resulting from industrial and urban activities. The results offer key insights to guide future sludge treatment and disposal at this landfill.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"46 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peiyu Jiang, Yiping Xu, Kaifeng Rao, Mei Ma, Zijian Wang
{"title":"Systematic Evaluation of Sampling Rate Influences and Variability in POCIS Using Meta-Analysis and Quantitative Structure Property Relationship (QSPR)","authors":"Peiyu Jiang, Yiping Xu, Kaifeng Rao, Mei Ma, Zijian Wang","doi":"10.1016/j.envpol.2025.125666","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.125666","url":null,"abstract":"Despite the significant benefits of aquatic passive sampling (low detection limits and time-weighted average concentrations), the use of passive samplers is impeded by uncertainties, particularly concerning the accuracy of sampling rates. This study employed a systematic evaluation approach based on the combination of meta-analysis and quantitative structure-property relationships (QSPR) models to address these issues. A comprehensive meta-analysis based on extensive data from 298 studies on the Polar Organic Chemical Integrative Sampler (POCIS) identified essential configuration parameters, including the receiving phase (type, mass) and the diffusion-limiting membrane (type, thickness, pore size), as key factors influencing uptake kinetic parameters. The incomplete availability of these details across studies potentially impacts data reproducibility and comparability. The subsequent meta-regression and subgroup analysis were performed to reveal the most significant factors contributing to sampling rate variability and inter-study heterogeneity. The flow rate and octanol-water partitioning (K<sub>ow</sub> or pH-dependent D<sub>ow</sub>) were identified from all environmental factors and chemical properties. Furthermore, the impact of chemical properties on the sampling rates of POCIS was predicted by Quantitative Structure-Property Relationship (QSPR) models using 2D descriptors and random forest regression. The analysis highlighted that the electrotopological state and molecular mass are the most important chemical properties influencing the sampling rate. This study systematically unraveled the most important impact factors on reliable estimates of passive sampling rates, and these causes of uncertainty should be further considered in aquatic monitoring and assessment with passive samplers.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"36 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of colloids with different compositions on benzophenone-3 biotoxicity in zebrafish embryos","authors":"Yu Sun, Guanghua Lu, Peng Zhang, Jiaqi Zhang, Yeting Yu, Fulin Li, Jian Liu","doi":"10.1016/j.envpol.2025.125670","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.125670","url":null,"abstract":"The fate of the pollutants in aquatic environment is closely related to colloids, and the carrier effect of colloids on pollutants not only affects their bioaccumulation, but may also affect their toxicity. In this study, the effects of natural colloid with different components on the biological toxicity of benzophenone-3 (BP3) to zebrafish larvae (<em>Diano rerio</em>) were studied. BP3 caused oxidative stress damage, thyroid system disorders and neurotoxicity in zebrafish larvae. And in the co-exposure groups, the organic and black carbon mineral (BCM) colloids enhanced the organism's antioxidant system by regulating the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx), reducing the lipid peroxidation damage in larvae. BCM colloids caused the thyroid system disorders in organisms, while organic colloids exacerbated the thyroid toxicity by transporting more BP3 into organisms, inducing severe abnormal heartbeats. The BCM and organic colloids regulated the acetylcholinesterase (AChE) activity and/or 5-hydroxytryptamine (5-ht) contents by affecting the neuroactive ligand receptor interaction pathway in zebrafish larvae, significantly increasing their swimming speed in co-exposure groups under the light condition. In addition, the effects of colloid-bound and freely dissolved BP3 absorbed by organisms on their physiological and biochemical activities were different. By analyzing the relative expression of the significant differential metabolites affected by BP3 in all experimental groups, it was found that colloid-bound and freely dissolved BP3 had a synergistic effect on most of these metabolites and pathways. However, the freely dissolved BP3 interfered with the purine metabolic pathway by mediating 2-(amidino)-n1-(5-phospho-d-ribosyl)acetamidine, and the tyrosine metabolic pathway by mediating choline and uranylacetic acid, while the colloid-bound BP3 has no or inverse regulatory effects on these three metabolites. This study provided a new perspective for the biotoxicity study of the pollutants in aquatic environment, necessitating a reconsideration of the real ecological risks of emerging pollutants in the presence of natural colloids.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"53 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dissolved beryllium (< 1 kDa) mobilized as a major element in groundwater in legacy mine waste","authors":"Lina P.B. Hällström, Björn Öhlander","doi":"10.1016/j.envpol.2025.125671","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.125671","url":null,"abstract":"Research regarding the geochemistry of beryllium (Be) in terrestrial environments is hindered by its high toxicity to humans and the low concentrations normally occurring in the environment. Although Be is considered an immobile element, extremely high dissolved concentrations have been detected in groundwater in the legacy Tailings Storage Facility (TSF) of Smaltjärnen, Sweden. Therefore, a detailed study was conducted to determine physiochemical parameters affecting the speciation of Be in the groundwater. Groundwater was sampled from 2016–2024 and filtered through 0.2 μm filters, whereas truly dissolved fraction (<1 kDa) samples were collected with dialysis membrane tubes in situ at groundwater wells. Secondary minerals on the tailings shore were studied by mineralogical methods and sequential extraction to trace the pathway whereby Be entered the downstream surface water. In part of the tailings, dissolved Be was detected in very high concentrations (average: 4.8 mg/L) in suboxic groundwater with pH from 6.0 to 6.4. Dialysis sampling in 2024 showed that more than 90% occurred as truly dissolved Be (<1 kDa). A significant correlation between Be and S was found, suggesting that sulfate complexes kept Be mobile in these pH conditions. Dissolved Be increased with decreased pH, and there is risk that the concentrations will increase further since sulfide oxidation with subsequent decrease in pH will continue for 100 of years in the TSF. In another part of the TSF, the pH was > 6.4 and dissolved Be was below the detection limit, possibly due to formation of Al(OH)<sub>3</sub> (>0.2 μm) together with F and Zn. Secondary minerals on the shore of the tailings functioned as a temporary chemical barrier, scavenging Be primarily by secondary gypsum when present and otherwise by Fe hydr(oxides).","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"7 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Key environmental predictors of Noctiluca scintillans distribution in the China Sea and its climate change response","authors":"Yiwen Xu, Yuxing Tang, Changyou Wang, Zhaohe Luo","doi":"10.1016/j.envpol.2025.125672","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.125672","url":null,"abstract":"<em>Noctiluca scintillans</em> is one of the most common harmful algal species worldwide. In this study, a MaxEnt model was constructed to calculate the present and future habitat suitability of <em>N. scintillans</em> in the China Sea. A comprehensive evaluation index of variable importance was defined to measure the importance of key predictors in the model, and offshore distance, long-term average minimum primary productivity, water depth, long-term average minimum temperature, and minimum salinity were determined as the dominant drivers. The HAB index that was constructed by integrating the carrying capacity and habitat suitability characteristics was used to measure the risk of harmful algal blooms (HABs). The index indicated that high-risk areas of HABs caused by <em>N. scintillans</em> occurred around Hainan Island, Taiwan Island, the coastal areas of Guangdong, Fujian, and Zhejiang provinces, and the eastern nearshore area of Weihai in Shandong. Regardless of the greenhouse gas emission scenario, the occurrence of <em>N. scintillans</em> red tides was predicted to persist until 2100. Moreover, the total area of the HABs high zone was predicted to increase under RCP2.6 and decrease under RCP8.5, and the center of the integrated HABs high zone was predicted to be concentrated in the central area of the entire China Sea spanning 15°N to 33°N.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"56 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Possible role of autophagy in microbial volatile pollutant-induced starch degradation and expression of hypoxia responsive genes","authors":"Chung-Chih Huang, Ching-Han Chang, Tu-Trinh Thi Truong, Wu-Guei Wang, Che Hui Lin, Chih-Yun Chiang, Iwai Obayashi, Hao-Jen Huang","doi":"10.1016/j.envpol.2025.125663","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.125663","url":null,"abstract":"Autophagy is thought to be critically involved in the regulation of nutrient metabolism and gene expression. Nevertheless, little is known about its role in regulating starch metabolism and hypoxia responsive genes in plants exposed to microbial volatile pollutants. In the present study, we found that exposure of <em>Arabidopsis</em> to <em>Enterobacter aerogene</em> (<em>E. aerogene</em>) volatile pollutants induced autophagy, as indicated by autophagosome formation. The exposure also caused upregulation of autophagy-associated genes, such as <em>ATGs</em>, <em>NBR1</em>, <em>ATI1</em>, and <em>ATG8e</em>-regulating transcription factors. Additionally, exposure to <em>E. aerogenes</em> volatile pollutants induced starch degradation in the roots of <em>Arabidopsis</em> seedlings. Finally, we found that ATG7-deficiency negatively affected the expression of hypoxia-responsive genes (i.e <em>HRE1</em>, <em>HRA1</em>, and <em>ADH1</em>) and starch degradation induced by <em>E. aerogenes</em> volatile pollutants. Overall, our study reveals that microbial volatile pollutants can induce starch degradation and autophagy, which participates in the regulation of some hypoxia-responsive genes and starch metabolism. These findings help to define the role of autophagy in plant nutrient metabolism and regulation of gene expression under microbial volatile pollutant exposure. The insights gained may contribute to agricultural management when living organisms face challenges from microbial volatile pollutants.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"35 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zemin Dong, Rendan Zhou, Wengen Wan, Han Li, Wenwen Zhou, Tianqi Wu, Lei Ding, Xiaoqin Xu, Dingwei Liu, Guangwei He, Jing Fan, Yuqi Li, Baotong Li
{"title":"Adsorption-desorption of propyrisulfuron in six typical agricultural soils of China: kinetics, thermodynamics, influence of 38 environmental factors and its mechanisms","authors":"Zemin Dong, Rendan Zhou, Wengen Wan, Han Li, Wenwen Zhou, Tianqi Wu, Lei Ding, Xiaoqin Xu, Dingwei Liu, Guangwei He, Jing Fan, Yuqi Li, Baotong Li","doi":"10.1016/j.envpol.2025.125653","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.125653","url":null,"abstract":"Propyrisulfuron, a novel sulfonylurea herbicide, effectively suppresses intracellular acetolactate synthase activity for weed control, but its adsorption behavior in the soil environment remains unclear. To assess potential agroecosystem risks, the adsorption-desorption behavior and mechanism of propyrisulfuron in six typical agricultural soils of China were investigated using a batch equilibrium method, Density Functional Theory (DFT), Fourier Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscopy equipped with Energy Dispersive X-ray (SEM-EDX) techniques. It is indicated that the adsorption-desorption of propyrisulfuron in six soils reached equilibrium at 36 hours under the optimum water-to-soil ratio (WSr) of 5:1. Adsorption kinetics followed the quasi-second-order kinetic model, while the Freundlich model best described the adsorption process at equilibrium. The adsorption and desorption were significantly and positively correlated with soil clay content, and 38 environmental factors had varying degrees of influence on its adsorption properties, especially those influenced by microplastics (MPs). Furthermore, the adsorption of propyrisulfuron in six soils was primarily a spontaneous, non-homogeneous, and non-ideal physical process, and special strong forces, such as hydrogen bonding might be involved. Consequently, due to its continuous application, potential persistent residues and pollution may occur in some soils. The investigations systematically reported the adsorption-desorption behavior of propyrisulfuron in various agricultural soils for the first time, providing scientific guidance for environmental risk assessment of groundwater pollution caused by its continuous application in agro-ecosystems.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"85 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dede Falahudin, Zainal Arifin, Deny Yogaswara, Edward Edward, Ita Wulandari, I Wayan Eka Dharmawan, Agus Sudaryanto, Anh Quoc Hoang, Shin Takahashi
{"title":"Halogenated organic compounds in mangrove sediments from Bintan Island, Indonesia: Occurrence, profiles, sources, and potential ecological risk","authors":"Dede Falahudin, Zainal Arifin, Deny Yogaswara, Edward Edward, Ita Wulandari, I Wayan Eka Dharmawan, Agus Sudaryanto, Anh Quoc Hoang, Shin Takahashi","doi":"10.1016/j.envpol.2025.125667","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.125667","url":null,"abstract":"The first comprehensive analysis of halogenated organic compounds (HOCs), including 209 full congeners of polychlorinated biphenyls (PCBs), 26 organochlorinated pesticides (OCPs), 41 polybrominated diphenyl ethers (PBDEs), and four other brominated flame retardants (BFRs), was performed on surface mangrove sediments from Bintan Island, Province of the Riau Archipelago, Indonesia. Among the measured HOC contaminants, the mean concentration of ∑<sub>209</sub>PCBs (2.3±0.96 ng g<sup>−1</sup> dw) was higher than that of <em>p,p’</em>-DDE (1.8±0.70 ng g<sup>−1</sup> dw), ∑<sub>41</sub>PBDEs (1.8±1.1 ng g<sup>−1</sup> dw), trans-nonachlor (0.42±0.13 ng g<sup>−1</sup> dw), and other BFRs (0.20±0.29 ng g<sup>−1</sup> dw), while other OCP related compounds less than 0.2 ng g<sup>−1</sup> dw. In addition, concentrations of unintentionally produced PCBs such as PCB-11 and PCB-47/48/75 ranged from 0.57−1.5 ng g<sup>−1</sup> dw. Variations in HOCs accumulation and profiles among mangrove habitats and species indicate different anthropogenic stressors and species-specific accumulations. The ecological risk estimation from HOCs exposure on dwelling sediment biota in mangrove sediments varied from no risk to potentially causing adverse effects in several locations. Overall, this study provides fundamental information on the function of mangrove ecosystems as an accumulation zone for HOCs in tropical regions.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"118 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guixiang Ji, Yiyi Wang, Zhixi Lu, Guangfeng Long, Cheng Xu
{"title":"Associations between Ambient Benzene and Stroke, and the Mediating Role of Accelerated Biological Aging: Findings from the UK Biobank.","authors":"Guixiang Ji, Yiyi Wang, Zhixi Lu, Guangfeng Long, Cheng Xu","doi":"10.1016/j.envpol.2025.125656","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.125656","url":null,"abstract":"Benzene can cause respiratory diseases. However, the associations between benzene and stroke are unclear. A total of 13,116 patients with stroke and 377,120 controls from the UK Biobank were included. The benzene exposure concentrations were matched on the basis of the address information of each participant via a data form from the UK Department for Environment, Food and Rural Affairs. Weighted Cox regression was used to investigate the association between benzene and stroke risk. The polygenic risk score (PRS) was used to observe the joint effects of benzene exposure and genetic factors on stroke risk. We conducted a mediation analysis to investigate the mediating role of accelerated biological aging in this cohort study. After adjusting for covariates, every 1 μg/m<sup>3</sup> increase in benzene exposure increased the risk of stroke by 70%, which may be mediated by accelerated biological aging. The population with high benzene exposure concentrations and high PRSs had a 44% greater risk of stroke than did those with low benzene exposure concentrations and low PRSs. Benzene exposure and the PRS have joint effects on the risk of stroke. Benzene exposure was associated with stroke risk, possibly through increased biological aging, and the PRS modified this association.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"14 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}