Environmental Pollution最新文献

{"title":"Kinetics of plasticiser release and degradation in soils","authors":"Alex Billings ,&nbsp;Kevin C. Jones ,&nbsp;M. Glória Pereira ,&nbsp;David J. Spurgeon","doi":"10.1016/j.envpol.2025.125997","DOIUrl":"10.1016/j.envpol.2025.125997","url":null,"abstract":"<div><div>Despite the increasing use of emerging phthalate and non-phthalate plasticisers as replacements for restricted phthalates, few studies have investigated their rates of entry and persistence in soils. We investigated release of the emerging plasticiser diethyl hexyl terephthalate (DEHTP) from polyvinyl chloride microplastics (PVC; 4 mm diameter; 21% DEHTP w/w) in soils in a 3-month laboratory study. DEHTP was released rapidly, with 6.6–12.1 ng DEHTP released per mg PVC within &lt;2 h, although this was a small proportion of the amount in the pellets (&lt;0.006%). Degradation rates of 8 phthalate plasticisers and 4 non-phthalate emerging plasticisers in the soils were measured in a separate 3-month laboratory study. For 7 of the 12 plasticisers, pseudo-first order half-lives were &lt;30 days, suggesting relatively low persistence. 5 higher molecular weight plasticisers, including the emerging trioctyl trimellitate and DEHTP, were more persistent, with half-lives &gt;100 days. Plasticiser half-lives in soils were significantly positively correlated with logK_OW. Degradation was typically slower in acidic heathland (pH 3.8; organic matter 3.7%), than in alkaline grassland (pH 7.3; OM 16%) or sandy loam agricultural (pH 5.3; OM 5%) soils. Rapid release and potential persistence of some emerging plasticisers in soils indicates that presence of these contaminants may increase in the future.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"372 ","pages":"Article 125997"},"PeriodicalIF":7.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PM10-bound elements in Luanda's urban atmosphere: Concentrations, sources, and their environmental and health impacts","authors":"Célia A. Alves ,&nbsp;Ana Sanchez de la Campa ,&nbsp;Yago Cipoli ,&nbsp;Leonardo Furst ,&nbsp;Gustavo Higawa ,&nbsp;Anabela Leitão ,&nbsp;Alan Victor da Silva ,&nbsp;Manuel S. Feliciano","doi":"10.1016/j.envpol.2025.125995","DOIUrl":"10.1016/j.envpol.2025.125995","url":null,"abstract":"<div><div>An unprecedented study was carried out in the megacity of Luanda, Angola, involving daily sampling of particulate matter (PM₁₀) from June to November 2023. The analysis was focused on the detection of 56 metal(loid)s and complemented by the application of several contamination and health risk indices. PM₁₀ levels ranged from 23.6 to 108 μg/m³, averaging 59.3 μg/m³, exceeding WHO's 24-h guideline on 83% of days. In addition to crustal elements, the most abundant constituents were Zn (159 ng/m³), Ba (43.2 ng/m³), Pb (17.8 ng/m³), Cu (10.5 ng/m³), Sr (7.0 ng/m³), Ni (4.5 ng/m³), Sb (3.7 ng/m³) and Cr (3.5 ng/m³). Mineral dust, primarily from unpaved roads and local soils, accounted for 31 wt% of PM₁₀, while sea salt contributed 6%. Geochemical markers (e.g., Ce-La-V relationships) suggest that vanadium originates predominantly from upper crust weathering. Elemental ratios such as Fe/Cu, Cu/Sb, and Zn/Sb indicate significant contributions from traffic-related emissions (e.g., brake and tyre wear) and industrial sources. Sulphur, an important PM₁₀ component, likely stems from fossil fuel combustion and petroleum refining. Luanda experiences severe air pollution, with high inputs from Sb, Cd, Zn, and other elements linked to traffic, industrial emissions, and biomass burning. The extremely high ecological risk (RI = 4360 ± 2440) highlights critical contamination, driven primarily by Cd and Sb, while the Nemerow risk index (1990 ± 1530) underscores urgent public health concerns. Non-cancer hazard indices (HI) exceeded safe thresholds for children (2.29) and adults (2.18), with Fe, Mn, Be, Pb, Ni, Co, and Sb identified as key contributors. Carcinogenic risks from PM₁₀ inhalation (2.34 × 10⁻³ for children and 1.36 × 10⁻³ for adults) also exceeded acceptable levels, emphasising the need for targeted pollution mitigation strategies.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"372 ","pages":"Article 125995"},"PeriodicalIF":7.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in chemical speciation and mobility of arsenic during the mixing of arsenic-bearing “snow-melting” system effluent and river water in the Ishikari Plain, Japan","authors":"Takahiko Arima ,&nbsp;Masataka Shimamura ,&nbsp;Asumi Sakaguchi ,&nbsp;Walubita Mufalo ,&nbsp;Carlito Baltazar Tabelin ,&nbsp;Toshifumi Igarashi","doi":"10.1016/j.envpol.2025.125998","DOIUrl":"10.1016/j.envpol.2025.125998","url":null,"abstract":"<div><div>An effective and ingenious method called “snow-melting” system was widely implemented for snow management in the Ishikari Plain, Japan. In this system, groundwater is pumped up, mixed with snow, and discharged into a nearby river. Since the groundwater in the Ishikari Plain is contaminated with arsenic (As), the impacts of directly discharging As-bearing groundwater into the river were assessed and monitored. In-situ monitoring data collected between 2013 and 2015 showed that As concentrations were higher in the groundwater (23–95 μg/L) than in the river water (2–71 μg/L). The major As speciation in the groundwater and river water were dissolved arsenite (As(III)) and As in suspended iron (Fe)-bearing solids, respectively. Precipitation of dissolved Fe when “snow-melting” system effluent mixes with the river water could be attributed to more oxic and oxidizing conditions of the resulting fluid mixture. Dissolved iron (Fe), mainly as ferrous ion (Fe²⁺), coexisted with dissolved As(III) in groundwater, so after mixing with the river water, Fe²⁺ was oxidized to ferric ion (Fe³⁺) and then precipitated as amorphous Fe oxyhydroxide phases that also sequestered dissolved arsenate (As(V)) via adsorption and coprecipitation. A strong correlation between As and Fe contents in river sediments was also observed, suggesting that Fe-bearing phases play an essential role in As immobilization. The results also showed a strong interaction between groundwater and river water that affected the chemical speciation and mobility of As and Fe. In addition, it was found that discharging As-bearing groundwater did not have profound impact on river water quality. Based on the results, dissolved Fe, Fe-bearing solid phases, and geochemical conditions strongly influenced how As speciates and migrates in a system where two fluids are mixed. This study could provide significant insights concerning the impacts of As on surrounding environments where As-bearing groundwaters are used and discharged without treatment.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"372 ","pages":"Article 125998"},"PeriodicalIF":7.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical and geometric property classification of natural aerosol types with a large open chamber system and multi-wavelength elastic polarized LiDAR","authors":"Juseon Shin ,&nbsp;Dukhyeon Kim ,&nbsp;Hyeyun Ku ,&nbsp;Youngmin Noh","doi":"10.1016/j.envpol.2025.125977","DOIUrl":"10.1016/j.envpol.2025.125977","url":null,"abstract":"<div><div>Natural aerosols, originating from uncontrollable processes, are widely distributed and often interfere with the remote sensing of anthropogenic aerosols. This interference occurs because distinguishing between particle types is challenging when they coexist. Despite their significant impact on radiative forcing and climate, research on natural aerosols remains limited due to their unpredictable nature. To address this, we implemented a pilot-scale open chamber system coupled with multi-wavelength elastic polarized LiDAR. This system enables the separation of target particles from ambient aerosols, enabling the development of a specialized analysis algorithm that calculates optical parameters—such as the Ångström Exponent (AE) and depolarization ratio (<span><math><mrow><mi>δ</mi></mrow></math></span>)— which serve as unique \"fingerprints\" for distinguishing aerosol types. Our experiments included some natural particles, such as yeast, whey protein, fly ash, flour, pine tree pollen, and kaolinite. Distinct optical properties were observed, with yeast exhibiting high δ values at 532 nm (0.31 ± 0.09) and 1064 nm (0.06 ± 0.01). Whey protein and fly ash were distinguishable based on AE values of −0.23 ± 1.16 and 0.31 ± 0.59, respectively. Pollen, another key natural aerosol, showed δ values of 0.33 ± 0.03 at 532 nm and 0.04 ± 0.01 at 1064 nm, enabling clear differentiation from other aerosol types. By incorporating infrared wavelengths into our LiDAR system, we enhanced the accuracy of aerosol characterization. This study highlights the approach for distinguishing natural aerosols and lays the groundwork for continuous monitoring systems to understand their atmospheric and climatic impacts better.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"372 ","pages":"Article 125977"},"PeriodicalIF":7.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of herbicide mixtures on the diversity and composition of microbial community and nitrogen cycling function on agricultural soil: A field experiment in Northeast China","authors":"Qingyun Ma ,&nbsp;Yiqing Zhou ,&nbsp;Rebecca E. Parales ,&nbsp;Siyu Jiao ,&nbsp;Zhiyong Ruan ,&nbsp;Lin Li","doi":"10.1016/j.envpol.2025.125965","DOIUrl":"10.1016/j.envpol.2025.125965","url":null,"abstract":"<div><div>Herbicide mixtures application is a widespread and effective practice in modern agriculture; however, a knowledge gap exists regarding the potential ecotoxicological effects of herbicide mixtures in agricultural systems. Here, the effects of various doses of herbicide mixtures (atrazine, nicosulfuron, and mesotrione) under different varieties of maize cultivation on the structure and function of microbial communities and soil chemical parameters were clarified through field experiments. The results showed that the application of herbicide mixtures increased the bacterial and fungal community alpha diversity at jointing and maturity, indicating a prolonged effect of the herbicide mixtures. Moreover, herbicide mixtures alter the composition of bacterial and fungal communities, with sensitive taxa suppressed and herbicide-tolerant taxa enriched. The herbicide mixtures significantly reduced the abundances of <em>Bacillus</em> even at lower doses, but <em>Penicillum</em> was enriched. FAPROTAX analysis and quantitative PCR (qPCR) results showed that herbicide mixtures inhibited the soil nitrogen-cycle process and related genes AOA<em>-amoA,</em> AOB<em>-amoA</em>, and <em>nifH</em> at maize seedling stage. Moreover, network analysis showed that low concentrations of the herbicide mixtures increased bacterial interactions while high concentrations inhibited them, which indicated that the network complexity may be herbicide concentration dependent. A synthetic community (SynCom) consisting of six bacterial strains was established for the biodegradation of the herbicide mixtures based on the analysis of the bacterial network, which resulted in an increase in the degradation efficiency of nicosulfuron by 15.90%. Moreover, potted maize experiment showed that the addition of the SynCom alleviated the toxic effects of herbicide mixtures on the plants. In summary, this study provides a comprehensive perspective for assessing the ecological risk at taxonomic and functional levels and the biodegradation approach of herbicide mixtures residue on agricultural soils in Northeastern China.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"372 ","pages":"Article 125965"},"PeriodicalIF":7.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tyre wear particles and metals in highway roadside ditches: Occurrence and potential transport pathways","authors":"Maria Polukarova ,&nbsp;Elly Lucia Gaggini ,&nbsp;Elisabeth Rødland ,&nbsp;Ekaterina Sokolova ,&nbsp;Mia Bondelind ,&nbsp;Mats Gustafsson ,&nbsp;Ann-Margret Strömvall ,&nbsp;Yvonne Andersson-Sköld","doi":"10.1016/j.envpol.2025.125971","DOIUrl":"10.1016/j.envpol.2025.125971","url":null,"abstract":"<div><div>Tyre wear particles (TWP) pose significant environmental concerns, necessitating a comprehensive understanding of their environmental distribution for accurate risk assessment. Roadside soil has not been extensively studied for TWP occurrence and distribution. This study aims to characterise the occurrence and distribution of TWP and associated metals in roadside soils and to investigate the correlations between these contaminants. Soil samples were collected from two road ditches along a Swedish national motorway at varying depths and distances from the contamination source. TWP in fractions &lt;500 μm were analysed using PYR-GC/MS. Results indicated that TWP concentrations in soil samples ranged from 0.74 ± 0.20 to 12.40 ± 1.88 mg/kg d.w., consistent with other studies, and decreased with distance from the road, similar to Zn. In one ditch, TWP concentrations remained constant with depth, unlike concentrations of Co and Cr, which increased, while in the other ditch, TWP and most metals did not decrease with depth or distance from the outlet. Strong correlations were found between concentrations of TWP and Zn in one, but not the other, where Zn might have followed different transport due to leaching. Metal correlations in both ditches suggest traffic-related but not necessarily tyre wear origins. These findings are crucial for risk assessments of traffic-related pollutants, particularly TWP, and their spread into soils.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"372 ","pages":"Article 125971"},"PeriodicalIF":7.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How fish intestinal cells responded to dietary methylmercury exposure? A single-cell transcriptomic analysis","authors":"Bingxin Yin ,&nbsp;Xun Wang ,&nbsp;Yong Liu ,&nbsp;Junhao Fang ,&nbsp;Wen-Xiong Wang","doi":"10.1016/j.envpol.2025.125967","DOIUrl":"10.1016/j.envpol.2025.125967","url":null,"abstract":"<div><div>Fish intestine is not only an important digestive and immune organ, but also serves as the first barrier to defend against methylmercury (MeHg) toxicity. Numerous studies have examined the responses of intestine to MeHg, whereas the heterogeneous responses of intestinal cells have not been addressed. In this study, the gilthead seabream were exposed to dietary MeHg, and the gene expression profiles of different intestinal cell populations were examined using scRNA-seq technique. We demonstrated that among the 14 cell types identified, enterocytes, macrophages, T cells and goblet cells were the primary target cell populations exhibiting specific responses to MeHg. Enterocytes appeared to play the most important role in the MeHg transport across the intestinal epithelium as well as intracellular storage. The immune pathways of macrophages and T cells were suppressed by MeHg, which also interfered with the mucus production and secretion in the goblet cells. Furthermore, MeHg not only affected the cell-cell adhesion of the target cells, but also resulted in disorder of lipid metabolism and immune function, thereby leading to increased susceptibility to pathogenic infections. This study provides an important understanding of the specific responses of intestinal cells to MeHg exposure at the cellular level.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"371 ","pages":"Article 125967"},"PeriodicalIF":7.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and spatial distribution of organophosphorus flame retardants in surface soils from typical petrochemical industry and flame retardant production parks in China","authors":"Zhiyong Fan ,&nbsp;Chaoyang Long ,&nbsp;Xiang Ge ,&nbsp;Zhaofa Huang ,&nbsp;Helong Ren ,&nbsp;Yingxin Yu ,&nbsp;Taicheng An","doi":"10.1016/j.envpol.2025.125972","DOIUrl":"10.1016/j.envpol.2025.125972","url":null,"abstract":"<div><div>Organophosphorus flame retardants (OPFRs) are widely used as flame retardants and plasticizers in various industries. As for the petrochemical industry, many petrochemical products such as lubricant base oil, gasoline, etc., require the use of OPFRs in their production processes. However, the emission characteristics of OPFRs from the petrochemical industry are limited. Thus, this study investigated the OPFR characteristics from three petrochemical industry parks, as well as one flame-retardant manufacturing park. There were 196 samples collected and thirteen OPFRs were analyzed. The median OPFR concentrations were 5.29–12.3 and 2.62 ng/g in three petrochemical industry parks and the flame-retardant manufacturing park, respectively. The OPFR compositions differed between petrochemical industry parks and flame-retardant production park. Chlorinated-OPFRs (especially TCIPP) accounting for ≥64.2% of the composition of soil OPFRs and alkyl-OPFRs (80.5%) were the respective predominant congeners in the petrochemical industry parks and the flame-retardant manufacturing park. Spatial distribution analysis revealed OPFR pollution within the park's vicinity, extending toward the surrounding areas. Principal component analysis further revealed that OPFRs primarily originated from industrial emissions, polyurethane foam use, and oil-related emissions for the petrochemical industry parks. However, high concentrations were also found in residential areas, farmlands, and populated areas from the flame-retardant manufacturing park and surrounding areas, indicating other potential sources. Summarily, this study provided insight into the contamination characteristics of OPFRs from typical industrial parks and their surroundings.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"371 ","pages":"Article 125972"},"PeriodicalIF":7.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term and low-dose exposure to triclosan induces POI phenotype in female offspring mice","authors":"Hongya Gan ,&nbsp;Yan Jiang ,&nbsp;Lixiang Wu ,&nbsp;Bingqi Zhu ,&nbsp;Dapeng Ji ,&nbsp;Jing Liu ,&nbsp;Zhishan Ding ,&nbsp;Xiaoqing Ye","doi":"10.1016/j.envpol.2025.125966","DOIUrl":"10.1016/j.envpol.2025.125966","url":null,"abstract":"<div><div>Triclosan (TCS), a typical endocrine disruptor, is widely used as an antibacterial agent in consumer goods. However, there are few studies on the effects of long-term low-dose TCS exposure on ovarian function in F1 female mice. In this paper, F1 female mice were exposed to TCS (0–3000 μg/kg/day) from intrauterine to postnatal day (PND) 91 to investigate its effects on the ovary. The results revealed that the number of total follicles was decreased, while atretic follicles was increased after TCS exposure. At the hormonal level, the secretion of estradiol was reduced, while follicle-stimulating hormone and luteinizing hormone were increased after TCS exposure. Observation of vaginal smear showed that TCS disrupted the estrous cycle of F1 female mice, especially at the dose of 3000 μg/kg/day. Moreover, TCS promoted cell apoptosis by activating the p38-MAPK signaling pathway and oxidative stress <em>in vitro</em>. In addition, analysis of the fecal microbiome and serum metabolomics revealed that exposure to TCS may cause gut microbiota disruption and metabolic abnormalities in F1 female mice. In conclusion, long-term low-dose TCS exposure may induce primary ovarian insufficiency phenotype in F1 female mice via inducing cell apoptosis and disrupting gut microbiota and metabolism.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"372 ","pages":"Article 125966"},"PeriodicalIF":7.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone exposure induced kidney damage in diabetic mice: The key role of lipid metabolism and water-electrolyte homeostasis","authors":"Yaru Zhang,&nbsp;Zhipeng Yan,&nbsp;Nan Nan,&nbsp;Shiya Li,&nbsp;Guohua Qin","doi":"10.1016/j.envpol.2025.125963","DOIUrl":"10.1016/j.envpol.2025.125963","url":null,"abstract":"<div><div>Ozone (O₃) is an important environmental pollutant that has garnered growing public concern. Epidemiological studies indicate that exposure to O₃ is associated with an elevated risk of kidney disease, a common complication of diabetes. However, the harmful effects of O₃ on the kidneys remain unconfirmed. Herein, we established models of non-diabetic and diabetic mice exposed to 0.5 ppm O₃ for 28 days (4 h/day). We evaluated O₃-induced renal injury and potential mechanisms through analyzing biochemical markers related to renal function, along with histopathology and transcriptomic sequencing of the kidneys. The results showed that O₃ exposure caused glomerular hypertrophy in both non-diabetic and diabetic mice, with mesangial hypercellularity and kidney function impairment specifically in diabetic mice. Furthermore, renal levels of free fatty acids and cholesterol were significantly elevated in O₃-exposed diabetic mice. The important roles of lipid and water-electrolyte metabolism related pathways in O₃-induced kidney damage were found by transcriptome sequencing analysis. The mRNA and/or protein expressions of some genes involved in β-ENaC and AQP2 pathways, which are related to renal water and sodium retention, were changed in diabetic mice following O₃ exposure by real-time quantitative PCR, immunofluorescence staining, and Western blotting. Overall, diabetic mice exhibited a higher vulnerability to adverse effects in the kidney after O₃ exposure than non-diabetic mice. Dysregulation of lipid metabolism and imbalance in water-electrolyte homeostasis have been discovered as key contributing mechanisms. This study offers valuable insights into mechanisms through which ambient O₃ poses renal health risks to both the general subjects and susceptible individuals.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"372 ","pages":"Article 125963"},"PeriodicalIF":7.6,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}