Environmental Pollution最新文献

{"title":"Assessment of human exposure to uncommon industrial toxicants in Glynn County, Georgia","authors":"Noah Scovronick ,&nbsp;Brooke Lappe ,&nbsp;Melanie A. Pearson ,&nbsp;Katy A. Smith ,&nbsp;Stephanie M. Eick ,&nbsp;Priya E. D'Souza ,&nbsp;Parinya Panuwet ,&nbsp;Minghao Kong ,&nbsp;Volha Yakimavets ,&nbsp;Rylee Stephenson ,&nbsp;Dana Boyd Barr","doi":"10.1016/j.envpol.2025.126240","DOIUrl":"10.1016/j.envpol.2025.126240","url":null,"abstract":"<div><div>Coastal Glynn County, Georgia, is home to four hazardous sites on the United States EPA's National Priorities List. Toxicants of concern include mercury, the pesticide toxaphene, and Aroclor 1268, a mixture of highly chlorinated polychlorinated biphenyls (PCBs); these toxicants are known to persist in the local environment and/or regional aquatic life, including local seafood. At the invitation of, and in partnership with, local community leaders and environmental groups, we conducted a human exposure study in Glynn County. The average age of the study participants was 61 years, 66 % were female, and 46 % were Black. Mercury levels in study participants were comparable to the general US population. Levels of less chlorinated PCBs (PCB 118, 138, 153 and 180) were lower in participants compared to the general population, but the highly chlorinated PCBs associated with Aroclor 1268 were elevated; 19.3 %, 25.0 % and 39.8 % of participants were above the estimated 95th percentile reference values for PCBs 196 + 203, 199, and 206, respectively. About 20 % of participants were above the 95th percentile reference level for both toxaphene Parlars tested (Parlars 26 and 50). We also report on several other toxicants including other metals (lead and cadmium), p,p’-DDE, and poly- and per-fluorinated alkyl substances (PFAS). This study provides evidence that toxicants associated with local hazardous sites have contributed to exposures in Glynn County residents, and that some residents have exposures far exceeding what is common in the general population.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"375 ","pages":"Article 126240"},"PeriodicalIF":7.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LiDAR-derived canopy structure explains 137Cs concentrations in throughfall in Fukushima plantation forest","authors":"Yupan Zhang ,&nbsp;Hao Wang ,&nbsp;Yuichi Onda ,&nbsp;Yiliu Tan ,&nbsp;Hiroaki Kato","doi":"10.1016/j.envpol.2025.126262","DOIUrl":"10.1016/j.envpol.2025.126262","url":null,"abstract":"<div><div>Following the Fukushima Daiichi nuclear power plant accident, approximately 1.8 PBq of Cesium-137 (¹³⁷Cs) got deposited in forested areas—2600 km² received more than 100 kBq/m² of ¹³⁷Cs. In Fukushima's predominantly cedar plantation forests, 60–90 % of the ¹³⁷Cs deposition was intercepted by the forest canopy. Previous studies have confirmed the gradual migration of cesium from tree canopies to the forest floor. However, these investigations have typically focused on plot-level trends, overlooking variations within the canopy itself. Our study aims to address this gap by employing terrestrial Light Detection and Ranging (LiDAR) scan to elucidate the relationship between ¹³⁷Cs activity/flux in throughfall and canopy characteristics post-accident. By defining a conical effective impact zone above each sampler and employing voxelization, we developed a robust and quantifiable method for assessing the impact of canopy volume on ¹³⁷Cs flux. We identified two distinct patterns: high penetration with low ¹³⁷Cs activity, and low penetration with high ¹³⁷Cs activity. Analyzing various rainfall events revealed that prolonged light rain often resulted in higher concentrations. Point cloud volume analysis within a 5° range conical zone above rain gauges indicated that larger canopy volumes correlated with reduced throughfall, leading to higher ¹³⁷Cs activity (R² = 0.308–0.578). Conversely, larger canopy volumes also increased ¹³⁷Cs flux (R² = 0.1879–0.7496). Hydrogen and oxygen stable isotope composition suggested significant canopy evaporation during extended periods of light rainfall, resulting in concentrated and elevated ¹³⁷Cs levels. This precise canopy quantification aids in understanding ¹³⁷Cs source allocation and exposure in forest ecosystems, providing a basis for radiation dose quantification and health risk assessment.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126262"},"PeriodicalIF":7.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multigenerational testing reveals delayed chronic toxicity of bisphenol A to Daphnia magna: A common characteristic of endocrine-disrupting chemicals?","authors":"Tan-Duc Nguyen ,&nbsp;Trong-Nhan Huynh ,&nbsp;Van-Tai Nguyen ,&nbsp;Khuong V. Dinh ,&nbsp;Claudia Wiegand ,&nbsp;Thanh Luu Pham ,&nbsp;Manh-Ha Bui ,&nbsp;Tomoaki Itayama ,&nbsp;Ngoc Tuan Tran ,&nbsp;Zhen Wang ,&nbsp;Thanh-Son Dao","doi":"10.1016/j.envpol.2025.126253","DOIUrl":"10.1016/j.envpol.2025.126253","url":null,"abstract":"<div><div>Bisphenol A (BPA) poses longstanding environmental concerns due to its widespread presence and recognized toxicity; however, its multigenerational ecotoxicity, in aquatic models such as water fleas, remains incompletely understood. This study examined the impact of sublethal BPA exposure on <em>Daphnia magna</em> across six generations, tracking changes in both life-history and population traits. Over the first five generations, BPA exposure produced minor and inconsistent effects on age at first oogenesis, age at first offspring production, growth rate, and fertility. The sixth generation exhibited prolonged oogenesis, delayed first offspring production, reduced body size, and decreased fertility, indicating delayed adverse effects. These multigenerational effects did not significantly alter population size or dynamics. Furthermore, BPA exposure did not affect feeding behavior in <em>D. magna</em> over six days, suggesting that food consumption-mediated mechanisms were unlikely a contributing factor. Our findings reveal BPA's delayed adverse effects on <em>D. magna</em> fitness, underscoring potential vulnerabilities for <em>D. magna</em> and other species under additional environmental stressors. These results support literature indicating that endocrine-disrupting chemicals can cause delayed and cumulative adverse effects on zooplankton descendants. Broadening multigenerational research to include a wider range of species, alongside sub-organismal analyses, is crucial to advancing regulatory frameworks and understanding underlying mechanisms.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126253"},"PeriodicalIF":7.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of bloom stage on the effectiveness of algicidal bacteria in controlling harmful cyanobacteria: A microcosm study","authors":"Jesús Morón-López ,&nbsp;Arnoldo Font-Nájera ,&nbsp;Mikolaj Kokociński ,&nbsp;Paweł Jarosiewicz ,&nbsp;Tomasz Jurczak ,&nbsp;Joanna Mankiewicz-Boczek","doi":"10.1016/j.envpol.2025.126261","DOIUrl":"10.1016/j.envpol.2025.126261","url":null,"abstract":"<div><div>Cyanobacterial harmful algae blooms (cyanoHABs) pose significant ecological and public health concerns in freshwater ecosystems worldwide. Understanding the dynamics of phytoplankton communities and the efficacy of mitigation strategies is crucial for managing bloom events. This study investigates the impact of bioaugmentation with algicidal bacteria on <em>Microcystis</em>-dominated blooms through laboratory microcosm experiments. Field-collected samples from MID- and POST-summer bloom stages were treated with <em>Morganella morganii</em>, <em>Exiguobacterium acetylicum</em>, and a bacterial consortium including <em>Bacillus pumilus</em>. Phytoplankton composition, microcystin concentrations and genes related to microbial community dynamics (16S, <em>mcy</em>A, <em>nos</em>Z and <em>amo</em>A) were assessed by microscopy, HPLC and qPCR, respectively. Results showed that <em>M. morganii</em> significantly altered the phytoplankton community structure and promoted diatom proliferation in MID-summer microcosms, though treatments were less effective in POST-summer microcosms representing more mature bloom periods. Additionally, algicidal bacteria influenced microcystin levels, with <em>M. morganii</em> and <em>E. acetylicum</em> reducing toxigenic <em>Microcystis</em> genotypes, as indicated by lower <em>mcy</em>A gene copy numbers. Molecular analyses also revealed that algicidal bacterial treatments contributed to shifts in microbial functional genes, including increased denitrification activity linked to <em>nos</em>Z gene abundance. These findings highlight the intricate interplay between algicidal bacteria and microbial communities, where algicidal activity extends beyond direct cyanobacteria suppression to broader ecosystem-level effects. By rebalancing phytoplankton communities toward eukaryotic dominance and reducing toxigenic cyanobacterial genotypes during intense bloom episodes, bioaugmentation with algicidal bacteria emerges as a promising strategy for bloom management and ecosystem restoration.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126261"},"PeriodicalIF":7.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen peroxide-aged biochar mitigating greenhouse gas emissions during co-composting of swine manure with rice bran","authors":"Zixun Chen,&nbsp;Peng Gao,&nbsp;Yaoxiong Lu,&nbsp;Xinwei Cui,&nbsp;Fuyuan Peng","doi":"10.1016/j.envpol.2025.126255","DOIUrl":"10.1016/j.envpol.2025.126255","url":null,"abstract":"<div><div>Compared to fresh biochar, aged biochar has a more significant effect on mitigating greenhouse gas (GHG) emissions in farmland soil. However, there is a relative scarcity of research addressing this effect in aerobic composting. In this study, a co-composting of swine manure and rice bran (NBC), with the addition of fresh biochar (FBC) and hydrogen peroxide-aged biochar (ABC), was conducted to investigate the dynamic changes in physicochemical properties, microbial communities, GHG emissions and related functional genes during different periods. In comparison to NBC, FBC led to a 32 % decrease in total GHG emissions (CO₂-equiv), including a 29 % reduction in CO₂ emissions, a 45 % reduction in CH₄ emissions, and a 35 % decrease in N₂O emissions. Furthermore, ABC resulted in a 14 % decrease in GHG emission (CO₂-equiv), comprising a 47 % reduction in CH₄ emissions and a 23 % decrease in N₂O emissions compared to FBC. These findings indicated that the addition of aged biochar has a more significant impact on GHG reduction during composting. Network analyses, Mantel tests and redundancy analyses suggested that the mechanism behind the lowest GHG emissions in ABC is the reduction of the relative abundance of fungi associated with CH₄ emissions, along with the <em>nirS</em> and <em>nirK</em> genes associated with denitrification. This reduction is associated with the decreasing anaerobic zones resulting from the increased pore volume in biochar after aging. Overall, this study demonstrates that hydrogen peroxide aging enhances the GHG-reducing efficiency in biochar, and provides new insights into the development of GHG-reducing technologies in composting.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126255"},"PeriodicalIF":7.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial plankton uptake enhances the degradation of a biodegradable microplastic","authors":"Luca Schenone ,&nbsp;Leonardo Capitani ,&nbsp;Ulises Lora ,&nbsp;Outi Setälä ,&nbsp;Hermanni Kaartokallio ,&nbsp;Jukka Seppälä ,&nbsp;Maiju Lehtiniemi","doi":"10.1016/j.envpol.2025.126252","DOIUrl":"10.1016/j.envpol.2025.126252","url":null,"abstract":"<div><div>The use of biodegradable plastics as an alternative to conventional non-degradable synthetic polymers is gaining market to reduce plastic pollution, however, their biodegradability is not unconditional. In this study, we hypothesized that planktonic protists (nanoflagellates and ciliates) increase the degradation of the biodegradable PLGA (poly(lactic-co-glycolic) acid) due to particle uptake. We conducted uptake and degradation experiments using PLGA microspheres of 4.9 ± 2.8 μm diameter and the microbial planktonic community from the Baltic Sea. We found that planktonic protists ingested PLGA of different sizes, with ciliates displaying higher clearance rates and ingesting larger particles compared to nanoflagellates. In addition, we observed a more pronounced decrease in PLGA concentration and particle size over time in the presence of seawater containing microbial plankton compared to a control with only ultrapure water, suggesting that the presence of these organisms increases the rate of degradation of PLGA in marine ecosystems. Altogether, these results indicate that microbial plankton enhances the degradation of biodegradable microplastics like PLGA, specifically through rapid uptake by planktonic protists. These findings highlight the role of particle ingestion by planktonic protists in the fate of the so-called biodegradable plastics when they enter aquatic ecosystems.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126252"},"PeriodicalIF":7.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofilm-mediated mass transfer of sorbed benzo[a]pyrene from polyethylene to seawater","authors":"Hongtao Liu ,&nbsp;Yongzheng Ma ,&nbsp;Jingen Xiao ,&nbsp;Ying Zhang ,&nbsp;Yuan Li ,&nbsp;Ao Shen ,&nbsp;Zhiguang Niu ,&nbsp;Qiqing Chen ,&nbsp;Baizhu Chen","doi":"10.1016/j.envpol.2025.126257","DOIUrl":"10.1016/j.envpol.2025.126257","url":null,"abstract":"<div><div>Plastic waste, including microplastics (MPs), often serves as a carrier for hydrophobic organic contaminants (HOCs) and additives in aquatic environments. However, little is known about the fate of contaminants in plastics, especially under the influence of biofilm in field conditions. In this study, polyethylene (PE) was pre-sorbed with varying concentrations of benzo[a]pyrene (BaP), a non-polar contaminant, and deployed <em>in situ</em> to study desorption kinetics under natural biofilm colonization. Based on the desorption kinetics of BaP from PE, a mass transfer model was developed to describe the desorption of non-polar contaminants from PE under the influence of biofilm formation. This study proved that biofilm, acting as an intermediary between plastics and the aquatic environment, did not serve as a sink for plastic-sorbed BaP, but accelerated the desorption process of BaP by reducing the partition coefficient between the plastic and the boundary layer. Furthermore, based on our developed model (IABL-ODD), the effects of biofilm on the fate of other non-polar and weakly polar contaminants in PE were predicted. This study highlights the influence of biofilm on the desorption of hydrophobic contaminants from plastics in field conditions and also informs future work on more relevant processes such as additive leaching.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126257"},"PeriodicalIF":7.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of microplastics in elevated risk and tissues metabolic alterations in uterine fibroid of female patients","authors":"Hongwen Xu ,&nbsp;Chunlin Dong ,&nbsp;Bing Zhang ,&nbsp;Yang Jin ,&nbsp;Jun Cheng ,&nbsp;Zhilong Yu ,&nbsp;Yukihiro Ozaki ,&nbsp;Jinjin Yu ,&nbsp;Ding Ma ,&nbsp;Yunfei Xie","doi":"10.1016/j.envpol.2025.126251","DOIUrl":"10.1016/j.envpol.2025.126251","url":null,"abstract":"<div><div>Microplastic (MP) pollution is an emerging environmental issue, drawing increasing attention to its potential harm to human reproductive health. This is a prospective study involving 160 human samples. MPs in tissue and blood samples were analyzed using Raman spectroscopy, while their impact on the metabolic characteristics of diseased tissues was evaluated using non-targeted techniques. The study finds that a total of 13 types of MPs are identified in all samples, with polyethylene and polypropylene being the most abundant polymers. Exposure levels of MPs are significantly higher in diseased tissues compare to normal tissues and tissues from healthy people (<em>p</em> &lt; 0.01). It is also find that exposure to polyethylene increases the risk of uterine fibroids (UFs) compare to healthy individuals. Additionally, the study finds a positive correlation between MP exposure levels and the size of UFs. This suggests that polyethylene may be linked to the growth of UFs. Metabolomics analysis reveals changes in the relative abundance of key differential metabolites. Certain metabolic pathways, such as amino sugar and nucleotide sugar metabolism pathways were significantly enriched and exhibited an upward trend, while the biosynthesis of cofactors, and platelet activation pathways showed a downward trend. The findings of this study suggest a potential association between MP exposure and the development and progression of UFs in women, offering valuable insights into the underlying mechanisms research.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126251"},"PeriodicalIF":7.6,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrastive cognition into the occurrence, source identification and risk assessment of antibiotics in various drinking water sources","authors":"Bingzheng Tian ,&nbsp;Min Zhang ,&nbsp;Chao Zhu ,&nbsp;Ruifang Yang ,&nbsp;Gaofang Yin ,&nbsp;Shuanggang Hu ,&nbsp;Yihan Chen ,&nbsp;Nanjing Zhao","doi":"10.1016/j.envpol.2025.126226","DOIUrl":"10.1016/j.envpol.2025.126226","url":null,"abstract":"<div><div>Antibiotics are prevalent in aquatic ecosystems, particularly in critical drinking water sources, posing serious threats to human health and ecosystems. Focusing on rivers, lakes, reservoirs and groundwaters in Anhui Province (China), this study systematically investigated the occurrence, influencing factors and source apportionment of antibiotics and assessed their ecological and health risks. The results indicated that the total antibiotic concentrations ranged from 0.04 to 215.13 ng/L, and lincosamides and sulfonamides were the primary antibiotic groups, with concentrations of nd-167.00 ng/L and nd-47.38 ng/L, respectively. Specifically, lincomycin (nd-159.38 ng/L) and clindamycin (nd-100.45 ng/L) were the concentration of the two highest antibiotics, while sulfamethoxazole had the highest detection frequency (86.16 %). The total concentration of antibiotics in rivers was significantly higher than in lakes, reservoirs, and groundwaters, and the structural composition of antibiotics in groundwaters differed distinctly from that in other water sources. Nitrogen levels showed significant spatial correlation with antibiotic distribution, and anthropogenic activities may exacerbate antibiotic contamination. The study identified farmland drainage and aquaculture as the main sources of antibiotics in rivers and reservoirs, respectively, while livestock was the main source in lakes and groundwaters. The maximum ecological and human health risk quotient (8.83 and 0.32) of rivers was higher than that of other water sources. Antibiotics posing ecological risks included sulfamethoxazole, lincomycin, clindamycin, and clarithromycin, while tylosin and lincomycin exhibited potential threats to human health. Although the risks posed by individual antibiotics and their combined effects were within acceptable limits, the long-term exposure to low-dose antibiotics in drinking-water sources warrants close attention and further investigation.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126226"},"PeriodicalIF":7.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of POP mixture redistribution and identification of their molecular signature in xenografted fat mice","authors":"Théo Jamay ,&nbsp;Philippe Noirez ,&nbsp;Haidar Djemai ,&nbsp;Layale Youssef ,&nbsp;Justine Massias ,&nbsp;Sadia Ouzia ,&nbsp;German Cano-Sancho ,&nbsp;Patricia Margaritte-Jeannin ,&nbsp;Florence Jornod ,&nbsp;Etienne B Blanc ,&nbsp;Xavier Coumoul ,&nbsp;Yann Guitton ,&nbsp;Bruno Le Bizec ,&nbsp;Jean-Philippe Antignac ,&nbsp;Philippe Marchand ,&nbsp;Covadonga Lucas-Torres ,&nbsp;Nicolas Giraud ,&nbsp;Gildas Bertho ,&nbsp;Min Ji Kim ,&nbsp;Karine Audouze","doi":"10.1016/j.envpol.2025.126239","DOIUrl":"10.1016/j.envpol.2025.126239","url":null,"abstract":"<div><div>Persistent organic pollutants (POPs) are associated with many adverse health effects in humans, including cancers, immune, reproductive, neurological disorders and metabolic diseases. These chemicals are known to accumulate in fatty tissues, from which they can be released in other tissue compartments of living organisms, in particular, upon weight loss. This dynamic distribution of POPs remains, however poorly investigated. In this study, a xenografted POP-contaminated adipose tissue (AT) model was used to assess 1) their concentrations in the ATs, the liver and the brain and 2) their associated effects by transcriptomics, metabolomics and lipidomics approaches. In the ATs, the liver and the brain of mice grafted with POP-contaminated fat pad, most of POPs were detected 3 days and 21 days after the graft with the highest concentrations in the ATs and the lowest concentrations in the brain. Conversely, per- and polyfluoroalkyl substances presented a distinct profile as they persist in the liver but not in the ATs or in the brain. In the AT of POP-exposed mice, the most dysregulated pathways were related to mitochondrial functions, endobiotic (carbohydrate, lipid, amino acid) and xenobiotic metabolism and inflammatory response. In the liver of grafted mice, many pathways related to mitochondrial functions and metabolism were dysregulated. These results support that realistic mixture of POPs that accumulate in AT and liver induces a systemic metabolic dysfunction which may represent the mechanisms by which the POPs can promote metabolic diseases such as obesity, type 2 diabetes and cardiovascular diseases.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126239"},"PeriodicalIF":7.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}