Risk identification of human health, ecotoxicity, and degradation products of azo dyes: development of a priority control list

IF 7.3 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Tong Li , Luanxiao Wei , Yisu Fang , Yuhan Cui , Xiajiao Wang , Yu Li
{"title":"Risk identification of human health, ecotoxicity, and degradation products of azo dyes: development of a priority control list","authors":"Tong Li ,&nbsp;Luanxiao Wei ,&nbsp;Yisu Fang ,&nbsp;Yuhan Cui ,&nbsp;Xiajiao Wang ,&nbsp;Yu Li","doi":"10.1016/j.envpol.2025.127180","DOIUrl":null,"url":null,"abstract":"<div><div>Azo dyes (ADs) are synthetic colorants with high stability and persistence, posing genotoxic, carcinogenic, and ecological risks. In this study, 56 ADs and 191 predicted degradation products were systematically assessed. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis quantified toxicity endpoints. The Criteria Importance Through Intercriteria Correlation (CRITIC) method determined indicator weights, while the Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) method validated robustness. A standard deviation approach was used to establish a priority control list, identifying seven ADs as being of special concern. Machine learning and factor analysis revealed that electronegativity, molecular volume, and nitro substituents were the key drivers of toxicity, while sulfonate groups reduced risks. Structural traceability confirmed that –N=N– bond cleavage produces hazardous aromatic amines. These findings provide a concise framework for risk identification, regulatory alignment, and prioritization of hazardous dyes, thereby supporting the development of safer alternatives.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"386 ","pages":"Article 127180"},"PeriodicalIF":7.3000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Pollution","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0269749125015544","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Azo dyes (ADs) are synthetic colorants with high stability and persistence, posing genotoxic, carcinogenic, and ecological risks. In this study, 56 ADs and 191 predicted degradation products were systematically assessed. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis quantified toxicity endpoints. The Criteria Importance Through Intercriteria Correlation (CRITIC) method determined indicator weights, while the Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) method validated robustness. A standard deviation approach was used to establish a priority control list, identifying seven ADs as being of special concern. Machine learning and factor analysis revealed that electronegativity, molecular volume, and nitro substituents were the key drivers of toxicity, while sulfonate groups reduced risks. Structural traceability confirmed that –N=N– bond cleavage produces hazardous aromatic amines. These findings provide a concise framework for risk identification, regulatory alignment, and prioritization of hazardous dyes, thereby supporting the development of safer alternatives.

Abstract Image

Abstract Image

偶氮染料的人类健康、生态毒性和降解产物的风险识别:制定优先控制清单
偶氮染料是一种具有高稳定性和持久性的合成着色剂,具有遗传毒性、致癌性和生态风险。本研究对56个ADs和191个预测降解产物进行了系统评价。吸收、分布、代谢、排泄和毒性(ADMET)分析量化了毒性终点。通过标准间相关性的标准重要性(critical)方法确定指标权重,而基于理想解相似性的顺序偏好技术(TOPSIS)方法验证了鲁棒性。采用标准偏差方法建立了优先控制清单,确定了特别关注的7个ad。机器学习和因素分析显示,电负性、分子体积和硝基取代基是毒性的关键驱动因素,而磺酸基降低了风险。结构可追溯性证实- N=N键裂解产生有害的芳香胺。这些发现为危险染料的风险识别、监管协调和优先排序提供了一个简明的框架,从而支持开发更安全的替代品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Environmental Pollution
Environmental Pollution 环境科学-环境科学
CiteScore
16.00
自引率
6.70%
发文量
2082
审稿时长
2.9 months
期刊介绍: Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信