Environmental Pollution最新文献

{"title":"Unseen threats: How nanoplastics trigger anxiety and depression-like behaviors in zebrafish (Danio rerio)","authors":"Meryem KANKAYNAR, Ekrem SULUKAN, Serkan YILDIRIM, Onur ŞENOL, Mehmet ATAKAY, Alper BARAN, Metin Kiliclioglu, İsmail BOLAT, Emriye YILDIZ, Hacer Akgül CEYHUN, Bekir SALİH, Saltuk Buğrahan CEYHUN","doi":"10.1016/j.envpol.2025.127229","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127229","url":null,"abstract":"Nanoplastics (NPs) are emerging contaminants of global concern, widely detected in water, air, and food, leading to continuous and largely unnoticed human and wildlife exposure. Despite increasing evidence of their neurotoxic potential, the mechanistic links between NP exposure and the development of neuropsychiatric disorders remain poorly understood. This study investigates whether early-life exposure to 20 nm polystyrene nanoplastics (PNPs) contributes to persistent behavioral and neurobiological changes associated with anxiety and depression. Zebrafish embryos were exposed to PNPs exclusively during early development and raised for six months before undergoing comprehensive behavioral, metabolomic, histopathological, immunohistochemical, and gene expression analyses. PNP-exposed fish exhibited lasting anxiety- and depression-like phenotypes, including heightened stress reactivity, disrupted circadian rhythms, increased social clustering, and altered locomotion. Multi-omics analyses revealed neurotransmitter imbalance, oxidative stress signatures, neuronal degeneration, and apoptotic activation in brain tissues, alongside stress-axis hyperactivation and impaired antioxidant defenses at the transcriptional level. Together, these findings provide mechanistic evidence that early-life NP exposure may be an overlooked environmental risk factor for anxiety and depression. By integrating behavioral and molecular endpoints in a translational zebrafish model, this study underscores the urgent need for global monitoring of nanoplastic contamination and its potential implications for human mental health.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"46 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the toxicity mechanism of copper tungstate (CuWO4) particles on the microalga Raphidocelis subcapitata assessed by multiple endpoints","authors":"Renan Castelhano Gebara, Cínthia Bruno de Abreu, Giseli Swerts Rocha, Marcelo Assis, Marisa Carvalho de Oliveira, Renan Augusto Pontes Ribeiro, Maria da Graça Gama Melão, Elson Longo","doi":"10.1016/j.envpol.2025.127250","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127250","url":null,"abstract":"Semiconductors have multiple applications in society, including photocatalysis and electrochemical sensors. Copper tungstate (CuWO₄) particles can degrade organic compounds from water, but their deleterious effects on aquatic biota must be evaluated before their widespread use. We aimed to assess the toxicity of CuWO₄ on the standardized microalga <em>Raphidocelis subcapitata</em> using a multiparameter approach. Our study comprehends the analysis of growth, lipid classes, carbohydrates, chlorophyll <em>a</em>, ROS production, photosynthesis, cell morphology, and theoretical calculations, to elucidate the toxicity mechanisms of this compound. We found that CuWO₄ affected the growth at 2.8 mg/L, followed by an increase in cell granularity and volume at 2.8 and 5.6 mg/L, respectively. We also observed increased intracellular ROS production, photosynthesis impairment, and changes in lipid classes (especially triacylglycerol - TAG, with potential to biofuels), carbohydrates and chlorophyll <em>a</em> content. Besides the toxic effects caused by copper ion release and the physical and chemical effects of the particles, experimental and theoretical chemical analysis showed that the semiconductor CuWO₄ itself produces oxidative species, especially photogenerated h⁺ (holes), and hydroxyl (⦁OH) and superoxide (⦁O₂^-) radicals, which can be associated with the localization of electronic levels summed to the undercoordination degree of the exposed surfaces. Our study shows that although CuWO₄ is promisor in water decontamination, it is toxic to a green microalga at the base of aquatic food chains, being a possible threat to these ecosystems. Further ecotoxicological studies with other aquatic organisms is highly advised to better understand the effects of this semiconductor on entire environments.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"72 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating links between long-term air pollution exposure and the risk of SARS-CoV-2 infection, COVID-19 hospitalisation and mortality: a systematic review and meta-analysis of cohort studies","authors":"Shawn Y. Lee, Abigail B. Schneider, Heather Walton, James Isaac, Anna Hansell, Klea Katsouyanni, Dylan Wood, Dimitris Evangelopoulos","doi":"10.1016/j.envpol.2025.127222","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127222","url":null,"abstract":"Air pollution exposure is suggested to be associated with SARS-CoV-2 infection and COVID-19 outcomes. Available systematic reviews and meta-analyses included studies of various study designs which could be vulnerable to ecological bias. We systematically reviewed the association between particulate matter less than 2.5 aerodynamic diameter (PM_2.5), nitrogen dioxide (NO₂), and ozone (O₃) and the risk of SARS-CoV-2 infection, COVID-19 hospitalisation, and COVID-19 mortality, focusing on cohort studies with individual-level data.A systematic literature search was conducted on MEDLINE and Scopus in July 2023 and subsequently updated in April 2025. The risk of bias of eligible studies was assessed using a modified Risk of Bias assessment instrument developed by the World Health Organization. Qualitative synthesis was performed on all eligible studies, and random-effects meta-analyses were performed when more than three studies were available for an exposure-outcome pair, after removing studies with overlapping populations.Long-term PM_2.5 exposure was associated with an increased risk of all outcomes investigated (RR for SARS-CoV-2 infection: 1.04 [1.02-1.07], RR for COVID-19 hospitalisation: 1.11 [1.06-1.15], RR for COVID-19 mortality: 1.09 [1.03-1.15], per 1 μg/m³ increase), whereas NO₂ exposure was associated with an increased risk of COVID-19 hospitalisation (RR: 1.02 [1.01-1.03], per 1 μg/m³ increase) and COVID-19 mortality (RR: 1.01 [1.01-1.02], per 1 μg/m³ increase). No associations were found for O₃ exposure. Univariate meta-regression suggested that country of study accounted for a substantial proportion of the heterogeneity observed in meta-analyses.This review presents a comprehensive, up-to-date synthesis of the evidence regarding the adverse effects of air pollutant exposure on COVID-19 outcomes based on robustly conducted cohort studies with individual-level information.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"1 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse adult-onset and multigenerational effects in zebrafish (Danio rerio) developmentally exposed to polystyrene nanoplastics","authors":"Mallory J. Llewellyn, Danielle N. Meyer, Amelia M. Paquette, Chia-Chen Wu, Dayita Banerjee, Adam F. Pedersen, Anna-Maria V. Petriv, Abraham Soto, Tracie R. Baker","doi":"10.1016/j.envpol.2025.127223","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127223","url":null,"abstract":"Microplastic (MP) and nanoplastic (NP) pollution has permeated virtually all aspects of life on earth – from high altitude clouds and arctic ice cores to single celled algae and unborn fetuses. Compared to MPs, the ability of NPs to infiltrate biological barriers such as the blood-brain and testes barriers is concerning to human health. Evidence of accumulation across human tissues has accrued, but the long-term health consequences are not well understood. Previously, we exposed zebrafish larvae to environmentally relevant doses of NPs (0 –10,000 parts per billion) for five days during early development, reporting NP accumulation, hyperactivity, and disruption of neuromuscular, metabolic, and epigenetic pathways immediately post-exposure. Here, we reared these developmentally exposed animals to adulthood, assessing reproductive capacity, offspring neurobehavior, and transcriptomics of brain and gonadal tissue for comparison. NP exposure impaired reproduction in adulthood: while high level exposure profoundly reduced overall spawning capacity, intermediate exposure also decreased fertilization of elicited eggs. Surviving offspring from the intermediate group were also hyperactive, like their parents, demonstrating a persistent and heritable neurobehavioral phenotype. Overall, far more significantly differentially expressed genes were found in adult tissues than in larvae; however, larval disruption of endocrine and neurological disease pathways persisted into adulthood. While female transcriptomics suggested recovery from early life NP exposure, male tissues were deleteriously and disproportionately affected. Male transcriptomics implicated neuromuscular and neurodegenerative diseases, endocrine disruption, and cancer. Oxidative stress was a consistently present mechanism underlying persistent disruption and adult-onset pathologies.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"40 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Spatial and Temporal Effects of urban vegetation coverage on Atmospheric Formaldehyde Pollution in Chinese Megacities over Recent Decades","authors":"Yuanyun Gao, Chengxin Zhang, Yuwen Yang, Xinhua Hong, Cheng Liu","doi":"10.1016/j.envpol.2025.127243","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127243","url":null,"abstract":"Urban vegetation coverage is widely promoted to improve livability and reduce pollutant exposure, yet its air-quality effects remain debated. Formaldehyde (HCHO), formed largely via oxidation of anthropogenic and biogenic VOCs, poses significant health risks and is a precursor of O₃ and PM_2.5. Here we examined how urban vegetation coverage was associated with HCHO across urbanization stages in Chinese megacities during 2005–2017. We integrated monthly OMI/Aura HCHO columns, MODIS-based Normalized Difference Vegetation Index (NDVI) (250 m), and Landsat-derived landscape metrics, harmonized on a common 0.1 grid. Cities were grouped into five urbanization classes via k-means on z-scored indicators (GDP per capita, population density, built-up ratio, and nightlights), with k = 5 supported by elbow, silhouette, and Calinski–Harabasz criteria. Associations between NDVI and HCHO were assessed using SRCC and spatial heterogeneity was evaluated with Geographically Weighted Regression (GWR). Across stages, the NDVI–HCHO association shifted from weakly negative in Class V (SRCC = −0.09, p &lt; 0.001) to strongly positive in Class III (SRCC = 0.81, p &lt; 0.001), then weakened in Classes II and I (0.63 and 0.72). Regionally, BTH and YRD showed concurrent increases in NDVI (3.29% and 5.94%) and HCHO (22.53% and 8.7%), whereas CY experienced a 10.18% NDVI rise but a 9.74% HCHO decline. GWR highlighted LPI as a robust structural predictor of HCHO variability across stages. These patterns are consistent with context-dependent interactions among BVOC potential, anthropogenic VOC/NOx, and meteorology. Our results caution against one-size-fits-all greening: the air-quality outcome of urban vegetation coverage depends on urbanization stage and landscape configuration. Differentiated planning and controlling anthropogenic precursors in more urbanized settings and optimizing vegetation type/patch structure around the Class III \"peak association\" can better align greening with HCHO mitigation.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"47 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of non-dietary human risks of neonicotinoids in China: environmental concentrations, human exposure and risk assessment","authors":"Liping Sun, Zhixuan Wu, Linping Cao, Guohua Zhu, Xiawen Qiu, Huajun Feng, Haifeng Zeng, Xinyan Zhou","doi":"10.1016/j.envpol.2025.127215","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127215","url":null,"abstract":"Neonicotinoids (NEOs) are extensively used in China and become a national concern due to their prevalence in the environment and human bodies. However, the non-dietary exposure to NEOs and their health risks to Chinese population remained unclear. This review compiled a comprehensive national dataset, comprising 39 studies on environmental concentrations across surface water, soil and indoor dust, as well as 20 studies on human internal exposure. Our analysis revealed that six NEOs, namely imidacloprid, acetamiprid, thiacloprid, dinotefuran, thiamethoxam and clothianidin, were widely distributed across all environmental media with distinct regional characteristics. Imidacloprid and acetamiprid exhibited relatively higher concentrations, while thiacloprid showed the lowest concentrations. Subsequently, people’s non-dietary exposure to NEOs based on NEO environmental concentrations was investigated, considering routes including oral intake, dermal contact and inhalation. Surface water was the primary source of non-dietary exposure, accounting for 65.1% to 98.2%, followed by indoor dust and soil. Regionally, Hainan, Zhejiang, Hebei exhibited relatively high non-dietary chronic daily intake values. Additionally, NEO concentrations in human blood and urine were analyzed across different populations, and total daily intakes of NEOs were estimated accordingly. Non-dietary exposure to NEOs contributed only 0.2% to 7.6% of the total NEO exposure, with children experiencing higher proportions. Although the carcinogenic and non-carcinogenic risks from non-dietary exposure to NEOs were relatively low, children faced significantly higher risks. Future studies should target on NEO management and control in aquatic environments, the combined health effects of NEOs and other contaminants, and strategies for protecting children from NEO exposure.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"35 1","pages":"127215"},"PeriodicalIF":8.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistically promoting humification and polluting gas reduction in cherry tomato straw composting via carbon bioavailability management","authors":"Jiacong Lin, Guangyi Li, Dingmei Wang, Yuqi Pang, Zhuoya Han, Xingwei Meng, Liwen Mai, Shiliang Peng, Qinfen Li","doi":"10.1016/j.envpol.2025.127207","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127207","url":null,"abstract":"The synergistic control of composting humification level and polluting gas emission reduction is a persisting challenge in aerobic composting. Numerous previous studies reported that the effects of various carbon source types or the total C/N ratios on the compost humification; However, only a few explored the role of carbon composition, particularly from a bioavailable quantization perspective. This study aimed to clarify the synergistic impact of bioavailable carbon composition and systematically accessed the interaction mechanisms that drove the composting. Six composting experiments with different content of bioavailable carbon were conducted and analyzed from four aspects, polluting gas emissions, compost characteristics, humification, and microbial community structure. The results indicated that a higher proportion of bioavailable carbon enhanced the transformation of organic matter, total nutrient, and available nutrient, accompanied by enhanced humification level of the compost. A slight increase in bioavailable carbon led to higher gas emissions (CO₂ equivalent emissions) to some extent. Only when the proportion of available carbon proportion I (ACC1) exceeded 60.31% (threshold value, T5 treatment) did the compost humification level and gas emission-reduction effect improve simultaneously. Under the T5 treatment, the nitrous oxide reduction rate reached 76.98% with its contribution to global warming potential decreasing to 21.0%.In this study, labile carbon component directly participated in the humification process and also indirectly enhanced the humification of compost and reduced pollutant gas emissions through the mediation of microbial communities. Overall, this study presented a comprehensive correlation network that links multiple composting parameters and identified the LCP1 was the key carbon component of carbon bioavailability. The findings offer a theoretical basis and empirical support for integrated improvement of compost humification efficiency, compost quality, and gas emission reduction in practical applications.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"89 1","pages":"127207"},"PeriodicalIF":8.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bisphenol A bis(diphenyl phosphate) disrupts gut microbiota homeostasis and induces intestinal toxicity in zebrafish","authors":"Yang Lyu, Xiao Wang, Yan Wang, Rongyan Yang, Wenjue Zhong, Lingyan Zhu","doi":"10.1016/j.envpol.2025.127221","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127221","url":null,"abstract":"Bisphenol A bis(diphenyl phosphate) (BDP), a widely used oligomeric organophosphorus flame retardant, is widespread in environments and organisms. However, the toxicity of BDP remains largely unexplored. The intestine is an immune organ and is subjected to injury caused by contaminants. Here zebrafish were exposed to 0, 10 and 100 μg/L BDP for 21d, followed by another 21d of recovery, to investigate its intestinal toxicity. BDP altered the gut microbiota compositions with obvious changes in the abundance of phyla Proteobacteria and Fusobacteria, and genera <em>Cetobacterium</em>, <em>Hydrogenophaga</em> and <em>Aeromonas</em>, leading to intestinal dysbiosis. Consequently, distinct intestinal histopathological alteration was observed in the BDP-exposed zebrafish. The expressions of <em>Claudin-1</em> and <em>Mucin 2</em> decreased dose-dependently, whose disruption was persistent, indicating that BDP destroyed the barrier integrity and function of intestine. In addition, superoxide dismutase (SOD) and malondialdehyde (MDA), as well as the expressions of <em>interleukin-1β</em> (<em>IL-1β</em>), <em>tumor necrosis factor-α</em> (<em>TNF-α</em>) and <em>transforming growth factor-β</em> (<em>TGF-β</em>) increased, magnifying the occurrence of oxidative damage and inflammation. Significant correlation was found between the microbiota alteration and intestinal disruptions, suggesting that BDP-induced gut microbiota dysbiosis participates in the progression of intestinal injury. This study reveals the intestinal toxicity of BDP, and provides insights into its potential risks in organisms.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"28 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress and metabolic adaptation in Synurella ambulans: Assessing pollution impact in the hyporheic zone","authors":"Zuzana Redžović, Marijana Erk, Sanja Gottstein, Inna M. Sokolova, Eugene P. Sokolov, Tatjana Mijošek Pavin, Sara Šariri, Mirela Sertić Perić, Jelena Dautović, Željka Fiket, Vlatka Filipović Marijić, Dušica Ivanković, Mario Cindrić","doi":"10.1016/j.envpol.2025.127234","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127234","url":null,"abstract":"Oxidative stress is a prevalent mechanism of physiological stress caused by exposure to pollutants or environmental hypoxia in aquatic organisms. The hyporheic zone (HZ), a transitional area between surface and groundwater with distinct ecological conditions, is highly susceptible to pollution and hypoxia, but the physiological responses of its aquatic inhabitants to these stressors remain poorly understood. The aim of this study was to investigate the effect of wastewater treatment plant (WWTP) effluent as a point source of contamination on the battery of biomarkers of antioxidant defence (catalase, CAT; glutathione reductase, GR), xenobiotic biotransformation (glutathione-S-transferase, GST), and aerobic/anaerobic energy metabolism (pyruvate kinase, PK; phosphoenolpyruvate carboxykinase, PEPCK; lactate dehydrogenase, LDH) in a stygophilous freshwater amphipod <em>Synurella ambulans</em> from the Sava River HZ. The samplings were conducted in relation to the Sava River’s hydrologic regime after low river discharge (in September 2020) and after high river discharge (in April 2021) at one site (Medsave) upstream of the WWTP outflow and at two sites downstream (Podsused and Jarun). <em>S. ambulans</em> populations at sites downstream of the WWTP showed higher CAT, GR, GST and LDH activity than population at the upstream site. PK/PEPCK ratio was significantly lower in the <em>S. ambulans</em> populations at Podsused and Jarun sites compared to Medsave population after low river discharge, indicating lower aerobic capacity and greater reliance on anaerobic metabolic pathways. This study improves the understanding of the physiological responses of crustaceans exposed to chemical pollution and environmental stressors, thus contributing to the ecological assessment of groundwater connected ecosystems.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"29 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function","authors":"Hanin Alahmadi, Maira Nadeem, Alixs M. Pujols, Raulle Reynolds, Mohammad Saiful Islam, Indrani Gupta, Courtney Potts, Allison Harbolic, Gania Lafontant, Somenath Mitra, Genoa R. Warner","doi":"10.1016/j.envpol.2025.127228","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127228","url":null,"abstract":"Exposure to micro- and nanoplastics is unavoidable. Foods and beverages contain plastic particles from environmental contamination and processing and packaging materials, which are frequently made of polyethylene terephthalate (PET). Micro- and nanoplastics have been detected in human tissues such as the brain, liver, and placenta, as well as in ovarian follicular fluid, but little is known about the effects nanoplastics have on the female reproductive system. In addition, few studies on the health impacts of nanoplastics have been performed using environmentally relevant plastic types and concentrations. Thus, this research tested the hypothesis that nanoplastics made of spherical polystyrene (PS), a common model nanoplastic, would have different effects on cultured mouse ovarian follicles compared to secondary PET nanoplastics at environmentally relevant doses. The ovary is a highly sensitive reproductive organ responsible for the development of follicles, which contain the oocyte, and production of steroid hormones. Follicles were harvested from adult mouse ovaries and cultured for 96 h with vehicle, spherical commercially available 220 nm PS nanoplastics (1–100 μg/mL), or lab-generated 240 nm PET nanoplastics (0.1–10 μg/mL). PS and PET nanoplastic exposure inhibited follicle growth and altered expression of genes related to steroid synthesis, cell cycle, and oxidative stress. PET nanoplastics increased levels of pregnenolone and decreased expression of <em>Cyp17a1</em>. Overall, both plastic types altered ovarian function, but they impacted different genes in similar pathways. These findings suggest that nanoplastic exposure at environmentally relevant concentrations may pose a risk to female reproductive health by disrupting hormonal and molecular pathways. In addition, environmentally relevant plastic types and doses are necessary for studying health impacts of nanoplastics.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"39 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}