Environmental Pollution最新文献

{"title":"Microplastic uptake with food increases risk-taking of a wide-spread decomposer, the common pill bug Armadillidium vulgare","authors":"Gergely Horváth, Dávid Herczeg, Boglárka Kovács, Ágnes Péntek, Bettina Kaczur, Gábor Herczeg","doi":"10.1016/j.envpol.2025.126220","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126220","url":null,"abstract":"Exposure to microplastics (MPs) i.e., plastic fragments between 1 μm and 1 mm in diameter causing growing concern for wildlife and humanity. It is now evident that MPs can accumulate in soil, freshwater, seawater and the atmosphere; thus, living organisms are directly or indirectly exposed to these significant ecological stressors globally. Studies on the physiological effects of MPs in wildlife are emerging, yet, to date, only a handful of studies with a special focus on how MPs affect animal behaviour are available, and there is even less research on how different components of among- and within-individual behavioural variation are affected by MPs. The main goal of this study was to investigate how prolonged exposure (6 weeks) to 10 μm spherical polystyrene microplastics in food (24.85 particles/mg) influences individual variation in risk-taking behaviour in a widespread decomposer, the common pill bug <em>Armadillidium vulgare</em>. Our results indicate a strong MP effect on different levels of behavioural variation: (i) individual mean risk-taking increased, while (ii) a correlation between mean risk-taking and residual within-individual risk-taking variation emerged (risk-takers became less predictable) in the MP treated group. These findings underscore the intricate effects of MPs on individual behavioural variation, with potentially far-reaching ecological and evolutionary consequences given their pervasive presence in both terrestrial and aquatic ecosystems. The negative impacts of these changes are widespread; in our study, MP exposure may increase the susceptibility of <em>A. vulgare</em> to predation, potentially contributing to population decline.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"10 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the distribution and transmission mechanism of ARGs in crab aquaculture ponds and ditches using metagenomics","authors":"Chao Li, Yun-xiang Zhu, Xiao-xiao Shen, Yuan Gao, Ming Xu, Meng-kai Chen, Ming-yang An","doi":"10.1016/j.envpol.2025.126209","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126209","url":null,"abstract":"Aquaculture provides notable economic benefits; however, the excessive use of antibiotics has resulted in the production and spread of antibiotic resistance genes (ARGs). The intricate pollution dynamics in aquaculture areas complicate the comprehension of the distribution and transmission of ARGs in aquaculture systems. Using metagenomic sequencing technology, this study used eight ponds and four ditches in a large crab aquaculture area in Taizhou City, where <em>Proteobacteria</em> (61.58%) and <em>Acidobacteria</em> (6.04%) were identified as the dominant phyla and <em>Thiobacillus</em> (1.84%) and <em>Lysobacter</em> (0.99%) were the dominant genera. Network and linear discriminant analysis effect size (LEfse) analyses showed that <em>Proteobacteria</em> and <em>Lysobacter</em> were the main host phyla of ARGs, and <em>Lysobacter</em>, which are key host bacteria in ponds, played an important role in determining the abundance of ARGs in ponds. Co-occurrence network analysis (spearman r&gt;0.7, p&lt;0.01) revealed that prophages can dominate the spread of ARGs by carrying several ARG subtypes (<em>rsmA</em>, <em>OXA-21</em>, <em>THIN-B</em> and <em>lnuF</em>). Analysis of variance demonstrated that functions related to the horizontal gene transfer (HGT) of ARGs, such as EPS synthesis (<em>lptF</em>), oxidative stress (<em>gor</em> and <em>ompR</em>), ATP synthesis (<em>lapB</em> and <em>vcaM</em>), and cell membrane permeability (<em>yajC</em> and <em>gspJ</em>), were significantly expressed in the pond (p&lt;0.05), confirming that ARGs had stronger transmission potential in the pond. The Mantel test and partial least squares path modeling (PLS-PM) analysis showed that ARGs exist in bacteria and spread among them through mobile genetic elements and HGT. This study revealed the distribution and transmission mechanism of ARGs in the ponds and ditches of a crab aquaculture system and provided a theoretical basis for controlling the spread of ARGs in crab aquaculture in this area.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"37 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-contaminant risks in water reuse and biosolids application for agriculture","authors":"Laura J. Carter, Beth Adams, Tamar Berman, Nririt Cohen, Eddie Cytryn, F.C.T. Elder, Andrea-Lorena Garduño-Jiménez, Danny Greenwald, Barbara Kasprzyk-Hordern, Hila Korach-Rechtman, Elma Lahive, Ian Martin, Evyatar Ben Mordechay, Aimee K. Murray, Laura M. Murray, John Nightingale, Adi Radian, Andrey Ethan Rubin, Brett Sallach, Dalit Sela-Donenfeld, Benny Chefetz","doi":"10.1016/j.envpol.2025.126219","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126219","url":null,"abstract":"Agriculture made the shift toward resource reuse years ago, incorporating materials such as treated wastewater and biosolids. Since then, research has documented the widespread presence of contaminants of emerging concern in agricultural systems. Chemicals such as pesticides, pharmaceuticals and poly- and -perfluoroalkyl substances (PFASs); particulate matter such as nanomaterials and microplastics; and biological agents such as antibiotic resistance genes (ARGs) and bacteria (ARB) are inadvertently introduced into arable soils where they can be taken up by crops and introduced to the food-web. Thus, concern about the presence of contaminants in agricultural environments has grown in recent years with evidence emerging linking agricultural exposure and accumulation in crops to ecosystem and human health effects. Our current assessment of risk is siloed by working within disciplines (i.e., chemistry and microbiology) and mostly focused on individual chemical classes. By not acknowledging the fact that contaminants are mostly introduced as a mixture, with the potential for interactions, with each other and with environmental factors, we are limiting our current approach to evaluate the real potential for ecosystem and human health effects. By uniting expertise across disciplines to integrate recent understanding regarding the risks posed by a range of chemically diverse contaminants in resources destined for reuse, this review provides a holistic perspective on the current regulatory challenges to ensure safe and sustainable reuse of wastewater and biosolids to support a sanitation-agriculture circular economy.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"59 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorophenols suppress gametogenesis by disrupting sex hormone signaling through DNA methylation in zebrafish","authors":"Rongjian Liu ,&nbsp;Dongqiong Wei ,&nbsp;Xuan Ma ,&nbsp;Jiamin Shi ,&nbsp;Yan Hu ,&nbsp;Samra ,&nbsp;Cong Yuan ,&nbsp;Yongmei Qi ,&nbsp;Dejun Huang","doi":"10.1016/j.envpol.2025.126221","DOIUrl":"10.1016/j.envpol.2025.126221","url":null,"abstract":"<div><div>Chlorophenols (CPs) are toxic pollutants widely present in the water environment. Yet their specific influence on gametogenesis remains unclear. This study investigated the impact of 2,4-dichlorophenol and pentachlorophenol on the gametogenesis of zebrafish. Results showed reduced egg production and sperm density in CP-exposed zebrafish, with an increase in the proportion of early germ cells and a decrease in mature germ cells. Additionally, the expression of gametogenesis-related genes (<em>nanos3</em>, <em>ccnd1</em>, <em>dmc1</em>) was upregulated, together confirming CPs suppress gametogenesis. The study also assessed the effects of CPs on sex hormone signaling, revealing altered ratios of estradiol to 11-ketotestosterone and changed expression of hormone receptors (<em>esrs</em> and <em>ar</em>). Besides, the hypothalamic-pituitary-gonadal axis genes showed significantly change, indicating the disorder of sex hormone signaling. Moreover, CPs increased DNA methylation levels in gonads, especially at CpG sites in the <em>ar</em> promoter, which negatively correlated with <em>ar</em> expression. Furthermore, elevated DNA methyltransferase (<em>dnmts</em>) expression was observed, and there was a significant interaction between CPs and Dnmts, suggesting CPs influence DNA methylation pathways. Overall, CPs inhibit gametogenesis by disrupting hormone signaling through DNA methylation. This study provides a new perspective on the toxic mechanisms and the risks posed by CPs to aquatic organisms.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126221"},"PeriodicalIF":7.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into fluoranthene degradation: Activation of peroxymonosulfate by mackinawite and pyrite in aqueous solution and soil slurry","authors":"Yulong Liu ,&nbsp;Meesam Ali ,&nbsp;Longbin Zhang ,&nbsp;Qian Sui ,&nbsp;Shuguang Lyu","doi":"10.1016/j.envpol.2025.126218","DOIUrl":"10.1016/j.envpol.2025.126218","url":null,"abstract":"<div><div>The slow regeneration of Fe(II) in conventional Fenton and Fenton-like systems poses significant limitations for sustained and continuous generation of reactive oxygen species (ROS), which is critical for effective pollutant degradation. This study investigates the use of iron sulfide minerals—specifically, mackinawite (FeS) and pyrite (FeS₂)—as both activators and reductants in peroxymonosulfate (PMS)-based Fenton-like systems to enhance Fe(II) regeneration and improve pollutant degradation efficiency. Results demonstrate that over 90 % of fluoranthene (FLT) was degraded within 60 min using the PMS/FeS and PMS/FeS₂ systems. Reactive species including SO₄⁻•, HO•, and ¹O₂ were generated in both systems, with SO₄⁻• playing a primary role in FLT degradation, while ¹O₂ contributed partially to the process. Both FeS and FeS₂ maintained structural stability during PMS activation, with surface Fe(II) oxidized to Fe(III) and reductive sulfur species (S²⁻ in FeS and S₂²⁻ in FeS₂) facilitating the Fe(III)/Fe(II) cycle before ultimately converting to SO₄²⁻. These systems demonstrated robust performance across diverse water matrices, achieving excellent FLT degradation in actual groundwater and soil slurry, underscoring the promising application potential of PMS/FeS and PMS/FeS₂ systems for remediating FLT-contaminated environments.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126218"},"PeriodicalIF":7.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Dispatched microbial community assembly processes driving ecological succession during phytostabilization of mercury-rich tailings’ [Environ. Pollut., 365 (2025) 125376]","authors":"Shengxiang Yang ,&nbsp;Bang Liu ,&nbsp;Lu Wang ,&nbsp;Robert Duran","doi":"10.1016/j.envpol.2025.126148","DOIUrl":"10.1016/j.envpol.2025.126148","url":null,"abstract":"","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"373 ","pages":"Article 126148"},"PeriodicalIF":7.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of BpTT2 overexpression in enhancing cadmium tolerence of Broussonetia papyrifera","authors":"Wan Zhang ,&nbsp;Jiayi Song ,&nbsp;Minghao Zhao ,&nbsp;Jiakang Zhou ,&nbsp;Yunlin Zhao ,&nbsp;Guiyan Yang ,&nbsp;Zhenggang Xu","doi":"10.1016/j.envpol.2025.126210","DOIUrl":"10.1016/j.envpol.2025.126210","url":null,"abstract":"<div><div>The development of cadmium-resistant plants has become a promising green biotechnology in the field of soil heavy metal remediation due to its advantages of low cost, wide adaptability and no secondary pollutants, it is the key to realize the application of this technology. In this study, we clarified the role of <em>BpTT2</em> in <em>Broussonetia papyrifera</em> in response to Cd stress. Under the induction of 500 μmol/L CdCl₂, the anti-Cd ability of <em>BpTT2</em>-overexpressed <em>B. papyrifera</em> was enhanced, and the accumulation of Cd was significantly reduced (<em>P</em> &lt; 0.05). The plant height, biomass and total chlorophyll content of <em>BpTT2</em>-overexpressed <em>B. papyrifera</em> were significantly higher than those of non-transgenic lines (<em>P</em> &lt; 0.001). Moreover, more substances related to ROS accumulation, such as MDA and H₂O₂, were detected in non-transgenic lines. Transcriptome sequencing showed that the AUX/IAA signal transduction gene (<em>ARF5</em>), ABA signal transduction genes (<em>PP2C</em> and <em>SNRK2</em>), protein kinase-related genes (<em>PHOT1</em>, <em>WAKL4</em>, <em>PK1</em> and <em>MPK3</em>), ROS accumulation-related genes (<em>RbohD</em> and <em>CAT1</em>), and TFs family genes highly sensitive to Cd stress were significantly up-regulated in <em>BpTT2</em>-overexpressed <em>B. papyrifera</em> (<em>P</em> &lt; 0.01). Notably, these genes regulate multiple signaling cascades simultaneously in the same protein family, which not only regulate plant signal transduction pathways, but also participate in the scavenging ROS and the feedback regulation of H₂O₂ signal. This study confirmed that the overexpression of <em>BpTT2</em> can enhance the remediation effect of <em>B. papyrifera</em> on soil Cd pollution, which has important significance for better utilization of phytoremediation technology to treat heavy metal pollution.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126210"},"PeriodicalIF":7.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Molecular Signatures for Azole Fungicides Toxicity in Zebrafish Embryos by Integrating Transcriptomics and Gene Network Analysis","authors":"Fatma Marghany ,&nbsp;Steve U. Ayobahan ,&nbsp;Gabriela Salinas ,&nbsp;Christoph Schäfers ,&nbsp;Henner Hollert ,&nbsp;Sebastian Eilebrecht","doi":"10.1016/j.envpol.2025.126215","DOIUrl":"10.1016/j.envpol.2025.126215","url":null,"abstract":"<div><div>Azoles control fungal growth by inhibiting sterol biosynthesis in fungi according to the fungicide resistance action committee. Furthermore, previous studies have highlighted several effects of azole fungicides in fish including endocrine disruption. In this study, we analysed the transcriptome responses of zebrafish embryos exposed to azole fungicides to identify gene expression fingerprints indicating toxic effects such as endocrine disruption induced by sterol biosynthesis inhibition. Firstly, a modified zebrafish embryo toxicity test was conducted following the OECD 236 guideline, exposing embryos to difenoconazole, epoxiconazole, and tebuconazole. After 96 hours, RNA was extracted for transcriptome analysis, which revealed concentration-dependent responses for each fungicide. Additionally, over representation analysis of significantly differentially expressed genes revealed biological functions related to sterol biosynthesis and endocrine disruption. Gene set with specific expression patterns was was identified as molecular signature for indicating adverse effects induced by sterol biosynthesis inhibitors in zebrafish embryos such as endocrine disruption. After further validation, the gene expression fingerprints and biomarkers identified in this study may be used in the future to identify endocrine activity of substances under development in a pre-regulatory screening using the zebrafish embryo model.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126215"},"PeriodicalIF":7.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Response and the Crucial Function of Predominant Phyla in Sedum alfredii-Mediated Remediation of High Concentration of Multiple Heavy Metal Soils","authors":"Han Zhang, Jianglong Cui, Ying Xiong, Guowen Li, Caili Du, Lieyu Zhang","doi":"10.1016/j.envpol.2025.126211","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126211","url":null,"abstract":"Phytoremediation of soils contaminated with high concentrations of multiple heavy metals (HCMHMs) is a promising technique. However, the microbial response mechanisms during the phytoremediation process remain poorly understood. The role of microbes in HCMHMs soil remediation may be underestimated. This study investigated microbial responses and their potential roles in HCMHMs soil remediation using the hyperaccumulator plant <em>Sedum alfredii</em> (<em>S. alfredii</em>). Soil microbial communities were characterised by 16S rRNA sequencing, and metabolic pathways and functions were predicted using PICRUSt2 analysis. The results indicated that the impact of heavy metals on bacterial community structure was more significant than that of <em>S. alfredii</em>. The formation of dominant phyla such as <em>Proteobacteria</em> and <em>Patescibacteria</em> played a crucial role in the bacterial remediation of HCMHMs soils. <em>Proteobacteria</em> utilised the <em>Inorganic ion transport and metabolism</em> gene clusters to translocate heavy metals or reduce their bioavailability and toxicity. <em>Patescibacteria</em> used the <em>Replication, recombination and repair</em> gene clusters to repair damaged genes, enhancing bacterial tolerance of heavy metals. The results provided new insights into the role of microbes during phytoremediation and offered a scientific basis for optimizing phytoremediation technologies. This study demonstrated that dominant phyla effectively mitigated the damage to soil ecological functions from HCMHMs soil.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"5 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of VOC transport parameters in artificial skin and the influence of temperature on permeability","authors":"Haimei Wang ,&nbsp;Rui Zhang ,&nbsp;Xueqiong He ,&nbsp;Lihua Sun ,&nbsp;Xuefei Yu ,&nbsp;Jing Zhao ,&nbsp;Shaodan Huang ,&nbsp;Jianyin Xiong","doi":"10.1016/j.envpol.2025.126212","DOIUrl":"10.1016/j.envpol.2025.126212","url":null,"abstract":"<div><div>Skin exposure represents a persistent and significant pathway for human exposure to gaseous volatile organic compounds (VOCs), whereas the underlying mass transfer mechanism remains inadequately explored. In this study, we propose a novel method to determine the key transport parameters by exposing artificial skin to gaseous VOCs, specifically the diffusion coefficient (<em>D</em>_m) and partition coefficient (<em>K</em>) which characterize the absorption and desorption of VOCs into skin. The key transport parameters of several highly-concerned VOCs are extracted by integrating experimental data with a developed skin model. Reliability and robustness of the method are validated via repeated experiments and uncertainty analysis. Our results show that variations in the physicochemical properties of VOCs result in distinct mass transfer characteristics through artificial skin. We further calculate the absorption resistance and average daily dose (ADD), and find that elevated artificial skin temperatures facilitate increased VOCs absorption. These findings provide a basis for better understanding gaseous VOCs dermal exposure, which is essential for accurate health risk evaluation.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126212"},"PeriodicalIF":7.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}