Environmental Pollution最新文献

{"title":"Multiple stressors may pose greater risks to macrophyte community dynamics by driving complex and unanticipated higher-order interactions.","authors":"Hongzhi Mao, Yuqing Tian, Guangrui He, Hui Yang, Lin Zhu, Zengjie Cun, Zhongqiang Li","doi":"10.1016/j.envpol.2026.128286","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.128286","url":null,"abstract":"<p><p>Freshwater ecosystems play a pivotal global role in water security and ecosystem services, but are increasingly threatened by multiple stressors, particularly emerging contaminants. These contaminants are in proximity to human activities and tend to accumulate in sediments, which further amplifies their ecological impacts on freshwater ecosystems. Nevertheless, most studies have focused on the effects of single or pairwise stressors, leaving the effects of complex higher-order interactions on macrophyte communities scant. Here, we conducted a full-factorial experiment using 96 glasshouse mesocosms in 10 L systems containing two macrophyte species (Lemna minor and Spirodela polyrhiza) maintained in a controlled glasshouse environment to investigate the single and higher-order interactive effects of the three emerging contaminants, including microplastics, antibiotics, and antiviral drugs, on two common free-floating macrophytes and their interactions. Our results show that individual and combined stressors cause species-specific responses in free-floating macrophytes, thereby directly or indirectly altering community dominance patterns. Multiple stressors mainly showed antagonistic interactions, triggering negative feedback regulation that alleviated macrophyte growth inhibition. And the feedback is context-dependent, as changes in environmental conditions and stressor combinations may reverse these feedback patterns, potentially enhancing ecological toxicity. Our findings highlight that the inherent complexity and unpredictability of higher-order interactions among multiple stressors can heighten risks to macrophyte communities. We advocate that evaluations of multiple stressors in freshwater ecosystems should integrate context-dependent responses, stressor interactions, and feedback due to redundancy and compensatory dynamics. Future studies should incorporate both biotic and abiotic stressors across multiple gradients and higher ecosystem levels, accounting for non-linear and context-dependent responses.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"128286"},"PeriodicalIF":7.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of morphological, physiological, transcriptomics and metabolomics analysis reveals the toxic effects of triadimefon on the earthworm.","authors":"Bidan Yin, Ruyi Gao, Hangyi Shi, Zhen Wang, Lijuan Liu, Canhui Nong, Chengliang Sun","doi":"10.1016/j.envpol.2026.128280","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.128280","url":null,"abstract":"<p><p>Triadimefon is a widely used triazole fungicide whose persistent residues may threaten soil fauna, yet its dose-dependent toxicological mechanisms in earthworms remain insufficiently understood. In this study, morphological, physiological, transcriptomic, and metabolomic analyses were integrated to investigate the toxic effects of triadimefon on the earthworm Eisenia fetida. Triadimefon caused dose-dependent growth inhibition and multi-tissue injury, including epidermal ulceration, muscular disorganization, and intestinal lesions. Ultrastructural observations and oxidative stress analyses further showed cytoplasmic vacuolization, mitochondrial and other intracellular organelle damage, disruption of antioxidant defenses, and increased oxidative DNA damage under high-dose exposure. Transcriptomic profiling revealed extensive molecular reprogramming, with low-dose exposure mainly affecting sensory-motor and locomotory functions together with lipid-related pathways, whereas high-dose exposure strongly suppressed DNA replication- and cell cycle-related processes. Untargeted metabolomics supported these changes and indicated a shift from adaptive metabolic adjustment at low doses to broader metabolic disturbance at high doses, including accumulation of the genotoxic metabolite (E)-2-hexenal. Overall, these findings demonstrate clear dose-dependent host toxicity of triadimefon in earthworms and provide mechanistic insight into how triazole fungicide residues may impair soil fauna.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"128280"},"PeriodicalIF":7.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galacto-oligosaccharides ameliorate polystyrene nanoplastic-induced anxiety- and depression-like behaviors via a gut-initiated serotonergic cascade.","authors":"Chang Liu, Bixuan Wu, Meixia Luo, Lin Li, Lu Li","doi":"10.1016/j.envpol.2026.128276","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.128276","url":null,"abstract":"<p><p>As emerging environmental contaminants, micro- and nanoplastics (MNPs) raise neurotoxic concerns. However, the mechanisms underlying their induction of emotional disorders remain poorly understood. In particular, intervention-oriented and functionally validated strategies for prevention and control are still lacking. To address this, we conducted a 28-day repeated oral exposure study in mice using a gradient of polystyrene nanoplastics (PS-NPs; 2, 10, and 50 mg/kg/day) spanning environmentally relevant doses, systematically assessing impacts along the microbiota-gut-brain axis. Our results showed that PS-NP exposure induced dose-dependent anxiety- and depression-like behaviors, with fluorescence tracing revealing predominant gut accumulation and limited brain distribution. Mechanistically, exposure induced gut microbiota dysbiosis, intestinal barrier impairment, and lipopolysaccharide translocation, ultimately leading to systemic inflammation and neuroinflammation. Serum biochemical analysis showed that gut dysbiosis initiates host tryptophan metabolism toward the kynurenine pathway by triggering inflammation and subsequent indoleamine 2,3-dioxygenase 1(IDO1) activation. Consistently, hippocampal transcriptomic and biochemical analyses confirmed decreased 5-HT levels and suppression of the downstream 5-HT₁A-cAMP-PKA-CREB-BDNF neurotrophic cascade, demonstrating comprehensive serotonergic disruption from substrate depletion to receptor dysfunction. Notably, the prebiotic galacto-oligosaccharides (GOS) restored intestinal homeostasis and ameliorated these anxiety- and depression-like behavioral and metabolic deficits, exerting protective effects by counteracting above pathway. Our work delivers a from-mechanism-to-solution understanding: it deciphers how microplastics disrupt the gut-brain axis to cause neurotoxicity and identifies GOS maintenance of intestinal health as a key mitigative strategy against plastic pollution risks. Therefore, maintaining intestinal health, particularly through dietary GOS, represents a viable strategy to mitigate the neurotoxicity induced by plastic pollution.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"128276"},"PeriodicalIF":7.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tritium forms and food availability modulate biological effects in marine mussels.","authors":"Maria Florencia Ferreira, Andrew Turner, Mickaël Payet, Olivier Debellemaniere, Christian Grisolia, Laurence Lebaron-Jacobs, Veronique Malard, Michael N Moore, Awadhesh N Jha","doi":"10.1016/j.envpol.2026.128254","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.128254","url":null,"abstract":"<p><p>During the decommissioning and normal operation of nuclear facilities, radionuclides like tritium (³H) that are associated with building materials (e.g., steel and cement), may be released as dusts. Tritiated particles ultimately reach the hydrosphere where they can bioaccumulate. In the present study, tissue-specific bioaccumulation and a range of biological responses were determined in the marine mussel, Mytilus galloprovincialis. Mussels were exposed for 72 h to: (a) tritiated stainless steel particles (T-SSPs), (b) T-SSPs + Algae, (c) tritiated water (HTO), (d) HTO + Algae. Use of HTO allowed discrimination between dissolved and particulate ³H accumulation while algae enabled assessment of the influence of food. Results showed that ³H accumulated mainly in the digestive gland (DG), and its accumulation was significantly higher in mussels exposed to T-SSPs compared to HTO at the same activity concentration, regardless of the presence of food. DNA damage determined using comet assay in haemocytes was evidenced after T-SSPs treatments, but not for mussels exposed to HTO. Clearance rate, a physiological parameter, was significantly increased after exposure to T-SSPs + Algae. Biochemical assays conducted in the DG showed a decrease in protein carbonyl content after exposure to HTO + Algae and T-SSPs + Algae, while autophagy levels increased following exposure to HTO regardless of the presence of food, and in mussels exposed to T-SSPs in the absence of food. Multivariate analysis and predicted 'scope for growth' suggested an adverse effect at the whole organism level following treatment with both T-SSPs and HTO, while the presence of food altered ³H bioaccumulation distribution. Our findings highlight the importance of studying accumulation of T-SSPs and the potential for biomagnification of radionuclides.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"128254"},"PeriodicalIF":7.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Response of ¹³⁷Cs dynamics in dam lakes to temperature and weather conditions\" [Environ. Pollut. 378, 126445].","authors":"Hideki Tsuji, Tatsuhiro Nishikiori, Shoko Ito, Hirokazu Ozaki, Mirai Watanabe, Masaru Sakai, Yumiko Ishii, Seiji Hayashi","doi":"10.1016/j.envpol.2026.128210","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.128210","url":null,"abstract":"","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"128210"},"PeriodicalIF":7.3,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen-dependent dynamics of metformin biodegradation at the sediment–water interface and non-additive effects on prokaryotic communities","authors":"Adrien Borreca ,&nbsp;Ariiheiura Tiatia ,&nbsp;Stéphane Vuilleumier ,&nbsp;Gwenaël Imfeld","doi":"10.1016/j.envpol.2026.127847","DOIUrl":"10.1016/j.envpol.2026.127847","url":null,"abstract":"<div><div>Metformin, a widely prescribed antidiabetic drug, is frequently detected in aquatic environments due to its limited removal during wastewater treatment. Yet its environmental behaviour and ecological effect on microbial communities at the biogeochemically active sediment–water interface remains poorly understood. We examined metformin degradation and its effect on prokaryotic communities under diverse controlled oxygenation conditions in laboratory microcosms mimicking the sediment–water interface. In autoclaved microcosms, metformin showed slow dissipation without significant formation of transformation products, irrespective of oxygenation conditions. In contrast, biotic microcosms showed metformin biodegradation within 13 days following a lag phase of up to 28 days. Degradation was faster under anoxic conditions. Guanylurea was the sole transformation product detected, suggesting enzymatic hydrolysis and potential use of dimethylamine and guanylurea as carbon and nitrogen sources for microbial growth. Prokaryotic community composition was significantly affected by oxygenation conditions and repeated metformin contamination. Metformin exposure and changes in oxygenation regime had predominantly additive effects. Nevertheless, non-additive effects on procaryotic community composition emerged over time, particularly after repeated metformin exposure. Twenty-one bacterial taxonomic biomarkers of metformin exposure were tentatively identified, including methylotrophic taxa potentially associated with the utilisation of metformin and its metabolites. Microbial activity was essential for metformin dissipation at the sediment–water interface, and oxygenation regime modulated the effect of metformin and its transformation on prokaryotic communities. Our study shows the importance of oxygenation conditions and microbial community responses in assessing the behaviour and associated risks of pharmaceuticals in dynamic aquatic environments such as the sediment–water interface.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"396 ","pages":"Article 127847"},"PeriodicalIF":7.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146231068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Widespread PFAS contamination in pet food: Dietary sources and health risks to companion animals’ [Environ. Pollut. 395, 15 April 2026, 127779]","authors":"Kei Nomiyama ,&nbsp;Aika Sato ,&nbsp;Rumi Tanoue ,&nbsp;Kohei Saeki ,&nbsp;Yoshinori Ikenaka ,&nbsp;Hazuki Mizukawa","doi":"10.1016/j.envpol.2026.127844","DOIUrl":"10.1016/j.envpol.2026.127844","url":null,"abstract":"","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"396 ","pages":"Article 127844"},"PeriodicalIF":7.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147278506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-organ toxicity induced by subacute inhalation exposure to rotenone in mice","authors":"Zengxue Liu ,&nbsp;Yuying Liu ,&nbsp;Li Zhang ,&nbsp;Daoyuan Bao ,&nbsp;Wenyuan Xu ,&nbsp;Tingting Meng ,&nbsp;Xinghe Han ,&nbsp;Wenyuan Hu ,&nbsp;Haiqun Cao ,&nbsp;Jinjing Xiao ,&nbsp;Yanhong Shi","doi":"10.1016/j.envpol.2026.127882","DOIUrl":"10.1016/j.envpol.2026.127882","url":null,"abstract":"<div><div>Rotenone is one of the most widely used botanical insecticides. During spraying and residue formation, it can create aerosols that enter the human body through the respiratory tract, posing significant environmental exposure risks. However, the toxicological mechanisms targeting specific organs after inhalation remain unclear, and research on multi-organ toxicity is currently lacking. This study employed in vivo experimental methods to establish an animal model simulating low-dose inhalation exposure scenarios. Mice were exposed to 0.5 h of daily inhalation of rotenone for 28 d at concentrations of 0.36, 3.6, and 5 mg/m³. Histopathological analysis revealed that rotenone exposure exerted toxic effects in the mice lung, brain, and ovarian tissues. The pro-inflammatory factors, tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and interleukin-2 (IL-2) were significantly elevated in both the brain and lung. The most significant increase in TNF-α levels was observed in brain tissue from the rotenone-treated group (214.52–381.31%). In addition, rotenone exposure reduced alpha diversity of lung microbiota and significantly (***, <em>p</em> ≤ 0.001) increased secretion of endocrine hormones (estradiol, progesterone, and testosterone). This study provides systematic evidence for rotenone-induced multi-organ toxicity following inhalation exposure, offering a new perspective for assessing the health risks of airborne pesticide residues.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"396 ","pages":"Article 127882"},"PeriodicalIF":7.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147292759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfluorooctane sulfonate (PFOS) induces Caspase-8-mediated pyroptosis via GSDMD and GSDME to drive retinal disease: Evidence from epidemiological and experimental studies","authors":"Lu-Yin Wu ,&nbsp;Li-Xia Liang ,&nbsp;Jia-Xin Zhou ,&nbsp;Yun-Ting Zhang ,&nbsp;Zeeshan Mohammed ,&nbsp;Muhammad Amjad ,&nbsp;Yang Zhou ,&nbsp;Zhi Wang ,&nbsp;Guang-Hui Dong ,&nbsp;Wen-Wen Bao","doi":"10.1016/j.envpol.2026.127896","DOIUrl":"10.1016/j.envpol.2026.127896","url":null,"abstract":"<div><div>While perfluorooctane sulfonate (PFOS) has been epidemiologically associated with ocular disorders, its direct specific role in retinal disease and the underlying molecular mechanisms are still not well understood. We initially examined serum PFAS levels in relation to retinal diseases among 777 participants (666 controls vs. 111 cases) from the Isomer of C8 Health Project in China. Then, C57BL/6 mice were orally gavaged with PFOS at doses of 0.8, 8, and 80 μg/kg/day for 90 days in vivo. The retinal ganglion cell line (RGC-5) was also exposed to PFOS at concentrations of 0, 1, 10, and 100 μM for 24 h in vitro. Epidemiological analysis showed a significant positive association between serum PFOS levels and the risk of retinal disease (OR = 1.46, 95%CI: 1.20, 1.80). In mice, exposure to PFOS caused progressive retinal thinning, retinal ganglion cell (RGC) loss, and retinal inflammation. In RGC-5 cells, PFOS activated Caspase-8, which led to cleavage of both GSDMD and GSDME, thereby inducing pyroptosis. Blocking Caspase-8 significantly reduced pyroptotic cell death involving GSDMD or GSDME. This study identifies PFOS as a new environmental trigger for retinal diseases through Caspase-8-mediated dual cleavage of GSDMD and GSDME. Our findings connect human exposure data with mechanistic toxicology and highlight the Caspase-8-gasdermin axis as a potential therapeutic target for PFOS related retinal disease.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"396 ","pages":"Article 127896"},"PeriodicalIF":7.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary metabolomics reveals associations between benzophenone exposure and thyroid function in children: A repeated-measures study","authors":"Kun Huang ,&nbsp;Shuoshuo Hu ,&nbsp;Yilin Zhou ,&nbsp;Biao Zhang ,&nbsp;Liangle Yang ,&nbsp;Wenqian Huo ,&nbsp;Zhenxing Mao ,&nbsp;Xiaomin Zhang","doi":"10.1016/j.envpol.2026.127876","DOIUrl":"10.1016/j.envpol.2026.127876","url":null,"abstract":"<div><div>Benzophenones (BPs) are potential thyroid hormone disruptors, but epidemiologic evidence in children and underlying biological mechanisms remain limited. In a panel study of 140 children (370 observations) aged 4-12 years with up to three visits, we measured five BPs in four-day pooled morning urine collected at each visit and assessed serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3). Untargeted urinary metabolomics was conducted in a subset of 48 children (144 observations) comparable to the overall children. A meet-in-the-middle (MITM) approach was applied to characterize underlying metabolic mechanisms. Mediation analysis was used to screen for potential mediating metabolites and to estimate the proportions mediated by individual and joint mediators. After false discovery rate correction, BP-1, BP-3, and BP-8 were significantly associated with elevated TSH and reduced FT3. Three multi-exposure models consistently indicated that the BP mixture was associated with increased TSH and decreased FT3, with BP-1, BP-3, and BP-8 identified as the primary contributors. The cysteine and methionine metabolism emerged as an overlapping pathway linking BP-3, BP-8, and the BP mixture to TSH. We identified 6, 9, and 8 significant mediating metabolites for the associations of BP-3, BP-8, and the BP mixture with TSH, respectively, accounting for mediated proportions of 11.5%–14.7%, 16.1%–25.3%, and 9.2%–15.1%. Among these mediators, dipeptides constituted the largest class, with five dipeptides identified. The combined mediation of multiple metabolites exceeded that of any single mediator, with total mediated proportions ranging from 20.2% to 42.1%. Integrated analyses revealed a cluster of children exhibiting elevated TSH, characterized by higher BP exposure and lower urinary levels of dipeptides, coenzymes, nucleotide metabolites, and others. Both individual and mixture exposures to BPs may alter thyroid function in children, with perturbations in cysteine and methionine metabolism and decreases in dipeptide-dominated urinary metabolites representing potential intermediate mechanisms.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"396 ","pages":"Article 127876"},"PeriodicalIF":7.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147278509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}